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https://www.readbyqxmd.com/read/29151960/r-e-n-a-l-nephrometry-score-a-preoperative-risk-factor-predicting-the-fuhrman-grade-of-clear-cell-renal-carcinoma
#1
Shao-Hao Chen, Yu-Peng Wu, Xiao-Dong Li, Tian Lin, Qing-Yong Guo, Ye-Hui Chen, Jin-Bei Huang, Yong Wei, Xue-Yi Xue, Qing-Shui Zheng, Ning Xu
Objective: The purpose of this study was to evaluate the efficacy and feasibility of the R.E.N.A.L. Nephrometry Score to postoperatively predict high-grade clear-cell renal carcinoma (ccRCC). Methods: The study included 288 patients diagnosed with ccRCC who had complete CT/CTA data and R.E.N.A.L. Nephrometry Scores and underwent renal surgery at our center between January 2012 and December 2015. The relationship between the pathological grade of renal masses and R.E.N.A.L. Nephrometry Score was evaluated. Results: Univariate analysis indicated that diagnostic modality, cystic necrosis, enlargement of the regional lymph node, distant metastasis, clinical T stage, TNM stage, surgical modality, tumor size, nearness of the tumor to the collecting system or sinus, total Nephrometry Score and individual anatomic descriptor components were significantly associated with postoperative tumor grade (P < 0...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29147624/high-cxc-chemokine-receptor-1-level-represents-an-independent-negative-prognosticator-in-non-metastatic-clear-cell-renal-cell-carcinoma-patients
#2
Yu Zhu, Zheng Liu, Yiwei Wang, Hangcheng Fu, Zewei Wang, Huyang Xie, Junyu Zhang, Gaoxiang Li, Bo Dai, Dingwei Ye, Jiejie Xu
CXC chemokine receptor 1 (CXCR1) signaling has been shown as an essential molecular nexus regarding cancer cell proliferation, tumor inflammation, and angiogenesis in clear cell renal cell carcinoma (ccRCC). The aim of this study was to investigate the prognostic significance of CXCR1 in patients with non-metastatic ccRCC. Data from 446 consecutive non-metastatic ccRCC patients, operated between 2003 and 2008 at a single institution, were evaluated retrospectively. The cohort was split into a training set (n = 223) and a validation set (n = 223)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29141518/surgical-management-of-renal-cell-carcinoma-extending-into-venous-system-a-20-year-experience
#3
X Xiao, L Zhang, X Chen, L Cui, H Zhu, D Pang, Y Yang, Q Wang, M Wang, C Gao
BACKGROUND AND AIMS: The purpose of this study is to report our 20-year experience with the surgical management of renal cell carcinoma extending into the inferior vena cava using a novel classification system. MATERIALS AND METHODS: We retrospectively reviewed the data of 103 patients (69 males, 34 females, mean age: 52.9 ± 12.6 years) with renal cell carcinoma involving the venous system treated between 1993 and 2014. The inferior vena cava tumor thrombus was classified into five levels: 0 (renal vein, n = 12), 1 (infrahepatic, n = 33), 2a (low retrohepatic, n = 26), 2b (high retrohepatic, n = 19), and 3 (supradiaphragmatic, n = 13)...
November 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29136713/-the-associations-between-adenosine-triphosphate-binding-cassette-subfamily-g-member-2-single-nucleotide-polymorphism-and-hyperuricemia-in-a-chinese-tertiary-hospital-faculty-cohort
#4
B Q Zhang, W G Fang, Y Zhang, S F Liu, X J Zeng
Objective: To investigate gender specific association between single nucleotide polymorphism rs2231142 and hyperuricemia. Method: A matched case-control study was conducted in a faculty cohort of a tertiary hospital in Beijing. The enrollment criteria were faculty member of the hospital with signed consent. The exclusion criteria were tumor, previous renal diseases, renal function damage, pregnancy, currently taking medicines that could increase or decrease serum uric acid level, and those who had gout. Males with serum uric acid>416...
November 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29126568/treatment-options-and-predictive-factors-for-recurrence-and-cancer-specific-mortality-in-bladder-cancer-after-renal-transplantation-a-multi-institutional-analysis
#5
O Rodriguez Faba, J Palou, H Vila Reyes, L Guirado, A Palazzetti, P Gontero, F Vigués, J Garcia-Olaverri, J M Fernández Gómez, J Olsburg, C Terrone, A Figueiredo, J Burgos, E Lledó, A Breda
OBJECTIVES: Bladder cancer (BC) in the transplanted population can represent a challenge owing to the immunosuppressed state of patients and the higher rate of comorbidities. The objective was to analyze the treatment of BC after renal transplant (RT), focusing on the mode of presentation, diagnosis, treatment options and predictive factors for recurrence. MATERIAL AND METHODS: We conducted an observational prospective study with a retrospective analysis of 88 patients with BC after RT at 10 European centers...
November 7, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29124239/impact-of-preoperative-proteinuria-on-renal-functional-outcomes-after-open-partial-nephrectomy-in-patients-with-a-solitary-kidney
#6
Hidekazu Tachibana, Tsunenori Kondo, Toshio Takagi, Masayoshi Okumi, Kazunari Tanabe
Purpose: To assess the impact of proteinuria on postoperative renal function after open partial nephrectomy (OPN) in patients with a solitary kidney and analyze predictive factors for developing chronic kidney disease (CKD) stage IV or higher. Materials and Methods: Patients with a solitary kidney who underwent OPN at Tokyo Women's Medical University Hospital between 1986 and 2016 were the subjects of this study. The patients were divided into 2 groups according to the presence of preoperative proteinuria...
November 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29114607/the-impact-of-different-stereotactic-radiation-therapy-regimens-for-brain-metastases-on-local-control-and-toxicity
#7
Rachel B Jimenez, Brian M Alexander, Anand Mahadevan, Andrzej Niemierko, Selvan Rajakesari, Nils D Arvold, Scott R Floyd, Kevin S Oh, Jay S Loeffler, Helen A Shih
Purpose: Stereotactic radiation therapy (SRT) enables focused, short course, high dose per fraction radiation delivery to brain tumors that are less ideal for single fraction treatment because of size, shape, or close proximity to sensitive structures. We sought to identify optimal SRT treatment regimens for maximizing local control while minimizing morbidity. Methods and materials: We performed a retrospective review of patients treated with SRT for solid brain metastases using variable dose schedules between 2001 and 2011 at 3 academic hospitals...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29113209/prognostic-value-of-copper-transporter-1-expression-in-patients-with-clear-cell-renal-cell-carcinoma
#8
Yu Xia, Li Liu, Qi Bai, Qilai Long, Jiajun Wang, Wei Xi, Jiejie Xu, Jianming Guo
Clear cell renal cell carcinoma (ccRCC) features a Von Hippel-Lindau mutation, associated with a hypoxia-inducible factor (HIF) imbalance. Copper transporter 1 (CTR1) may also promote tumor progression through the modulation of the HIF pathway by copper. Therefore, the present study explored the prognostic effect of tumor CTR1 expression in patients with ccRCC. A total of 293 patients with ccRCC that underwent nephrectomy were retrospectively enrolled. CTR1 expression was assessed by immunohistochemistry, and its association with clinicopathological features and prognosis were evaluated...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29108390/high-truncated-o-glycan-score-predicts-adverse-clinical-outcome-in-patients-with-localized-clear-cell-renal-cell-carcinoma-after-surgery
#9
SonTung NguyenHoang, Yidong Liu, Le Xu, Lin Zhou, Yuan Chang, Qiang Fu, Zheng Liu, Zongming Lin, Jiejie Xu
Truncated O-glycans, including Tn-antigen, sTn-antigen, T-antigen, sT-antigen, are incomplete glycosylated structures and their expression occur frequently in tumor tissue. The study aims to evaluate the abundance of each truncated O-glycans and its clinical significance in postoperative patients with localized clear-cell renal cell carcinoma (ccRCC). We used immunohistochemical testing to analyze the expression of truncated O-glycans in tumor specimens from 401 patients with localized ccRCC. Truncated-O-glycan score was built by integrating the expression level of Tn-, sTn- and sT-antigen...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108268/inherent-characteristics-of-metachronous-metastatic-renal-cell-carcinoma-in-the-era-of-targeted-agents
#10
Jang Hee Han, Seung Hwan Lee, Won Sik Ham, Woong Kyu Han, Koon Ho Rha, Young Deuk Choi, Sung Joon Hong, Young Eun Yoon
Background: To assess the prognostic and predictive factors of time to treatment failure (TTF) and overall survival (OS), respectively, in patients with metachronous metastatic renal cell carcinoma (mRCC) who were treated with targeted agents. Materials and Methods: We retrospectively reviewed metachronous mRCC patients, defined as individuals diagnosed with metastatic disease >3 months after initial nephrectomy, treated at an institute since 2005. Cox proportional hazard regression analysis was performed to discover the most determinant variables associated with TTF and OS...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098196/perirenal-abscess-after-partial-nephrectomy-because-of-migration-of-upper-calix-stone-and-urine-leakage-a-case-report
#11
Sheng-Chun Hung, Li-Wen Chang, Cheng-Kuang Yang
Background: Nephron-sparing surgery has been shown to achieve oncological results equivalent to those of radical nephrectomy in patients with compromised renal function who have renal tumors <4 cm. However, technical difficulties and potential surgical complications remain challenges to the surgeon. Various factors, such as tumor size and location, collecting system invasion, and patient's expectations, are major concerns that may affect the feasibility of performing an effective partial nephrectomy. We report a patient with renal cell carcinoma who underwent open partial nephrectomy and suffered from complications of perirenal abscess because of stone migration, obstruction, and subsequence urine leakage...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29094888/bladder-cancer-diagnosis-and-treatment
#12
Katharine C DeGeorge, Harry R Holt, Stephanie C Hodges
Bladder cancer is the sixth most prevalent malignancy in the United States and causes more than 16,000 deaths annually. The most common clinical presentation is asymptomatic hematuria, which should prompt evaluation with cystoscopy, renal function testing, and upper urinary tract imaging in adults 35 years and older and in those with irritative voiding symptoms, risk factors for bladder cancer, or gross hematuria at any age. Transurethral resection of the bladder tumor allows for definitive diagnosis, staging, and primary treatment...
October 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29092949/integrative-analysis-of-histopathological-images-and-genomic-data-predicts-clear-cell-renal-cell-carcinoma-prognosis
#13
Jun Cheng, Jie Zhang, Yatong Han, Xusheng Wang, Xiufen Ye, Yuebo Meng, Anil Parwani, Zhi Han, Qianjin Feng, Kun Huang
In cancer, both histopathologic images and genomic signatures are used for diagnosis, prognosis, and subtyping. However, combining histopathologic images with genomic data for predicting prognosis, as well as the relationships between them, has rarely been explored. In this study, we present an integrative genomics framework for constructing a prognostic model for clear cell renal cell carcinoma. We used patient data from The Cancer Genome Atlas (n = 410), extracting hundreds of cellular morphologic features from digitized whole-slide images and eigengenes from functional genomics data to predict patient outcome...
November 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/29064751/alternative-response-criteria-and-clinical-risk-factors-for-assessing-tumor-response-in-patients-with-metastatic-renal-cell-carcinoma-who-are-receiving-salvage-therapy
#14
Hyunseon C Kang, Shiva Gupta, Wei Wei, Lina Lu, Marc R Matrana, Nizar M Tannir, Haesun Choi
OBJECTIVE: The purpose of this study is to compare the prognostic value of various solid tumor response criteria as well as the additive value of clinical risk factors in patients with advanced renal cell carcinoma (RCC). MATERIALS AND METHODS: Two sets of CT scans (pretreatment scans and scans obtained 1-3.5 months after treatment) were reviewed for 57 patients with metastatic RCC treated with pazopanib in the salvage setting. Tumor response on the posttherapy scan was evaluated using Response Evaluation Criteria in Solid Tumors (RECIST) and Choi, modified Choi (mChoi), MASS (Morphology, Attenuation, Size, and Structure), and 10% threshold criteria...
December 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29051029/recent-advances-in-localized-rcc-a-focus-on-vegf-and-immuno-oncology-therapies
#15
REVIEW
Pearl Subramanian, Naomi B Haas Md
Recent advances in advanced renal cell cancer (RCC) research have produced new drugs and therapies for patients with metastatic disease leading to higher response rates, improvements in progression-free survival, and longer overall survival. These advances have yet to be realized in patients with early-stage kidney cancer, and to date, no drug has been approved for the adjuvant treatment of localized kidney cancer. The current standard of care for localized high-risk kidney cancers is resection of the primary tumor...
October 16, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29048977/off-clamp-robot-assisted-partial-nephrectomy-how-far-shall-we-proceed
#16
Ali Abdel Raheem, Glen Denmer Santok, Lawrence H C Kim, Ki Don Chang, Trenton G H Lum, Young Eun Yoon, Woong Kyu Han, Young Deuk Choi, Koon Ho Rha
BACKGROUND: Off-clamp robot-assisted partial nephrectomy (RAPN) is associated with increased intraoperative blood loss compared with on-clamp technique. Our aim was to demonstrate our surgical technique and to determine which tumors are ideally suited for this technique. METHODS: Sixty-two patients who underwent off-clamp RAPN for renal tumor between 2006 and 2016 were retrospectively analyzed. Increased estimated blood loss (EBL) volume was defined as more than 75 percentile...
October 19, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29045502/long-term-toxicity-of-cisplatin-in-germ-cell-tumor-survivors
#17
M Chovanec, M Abu Zaid, N Hanna, N El-Kouri, L H Einhorn, C Albany
Context: Testicular germ-cell tumors (GCT) are highly curable. A multidisciplinary approach, including cisplatin-based chemotherapy has resulted in cure in the majority of patients with GCT. Thus, the life expectancy of survivors will extend to many decades post-diagnosis. Late treatment toxicities associated with cisplatin-based chemotherapy may impact their future health. Objective: To systematically evaluate evidence regarding the long-term toxicity of cisplatin in GCT survivors...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29042282/increased-levels-of-circulating-tnf-%C3%AE-is-associated-with-308g-a-promoter-polymorphism-of-tnf-%C3%AE-gene-in-diabetic-nephropathy
#18
Dhamodharan Umapathy, Ezhilarasi Krishnamoorthy, Vairamani Mariappanadar, Vijay Viswanathan, Kunka Mohanram Ramkumar
The crucial role of Tumor Necrosis Factor-α (TNF-α) on renal function in patients with Diabetic Nephropathy (DN) has been well documented. The present study was designed to investigate the association of TNF-α [-308G/A, (rs1800629)] single nucleotide polymorphism (SNP) on the susceptibility to DN subjects and to correlate it with the plasma levels of TNF-α along with circulatory TNF-α receptor super family cytokines (sTNFR-1 and sTNFR-2). A total of 756 subjects, were recruited and divided into groups [Group-I, Control (n=218), Group-II, Normoalbuminuria (n=196), Group-IIIa, Microalbuminuria (n=178), Group-IIIb, Macroalbuminuria (n=164)] and were genotyped by PCR-restriction fragment length polymorphism (RFLP)...
October 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29037450/tissue-expression-of-tubular-injury-markers-is-associated-with-renal-function-decline-in-diabetic-nephropathy
#19
Subin Hwang, Jeeeun Park, Jinhae Kim, Hye Ryoun Jang, Ghee Young Kwon, Wooseong Huh, Yoon-Goo Kim, Dae Joong Kim, Ha Young Oh, Jung Eun Lee
AIMS: The pathogenesis of diabetic kidney disease (DKD) is complex and multifactorial; increasing evidence suggests that tubular injury and inflammatory process are involved in disease progression. We investigated the potential association of renal expression of tubular injury markers, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and inflammatory markers, tumor necrosis factor receptor (TNFR) 1 and 2 with renal progression in pathologically proven diabetic nephropathy (DN)...
August 24, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29034078/recent-advances-in-cancer-surgery-in-older-patients
#20
REVIEW
Siri Rostoft, Riccardo A Audisio
Age is the most important risk factor for the occurrence of cancer, and a declining mortality from heart disease and other non-cancer causes leaves an older population that is at high risk of developing cancer. Choosing the optimal treatment for older cancer patients may be a challenge. Firstly, older age and associated factors such as comorbidities, functional limitations, and cognitive impairment are risk factors for adverse effects of cancer treatment. Secondly, older patients are often excluded from clinical trials, and current clinical guidelines rarely address how to manage cancer in patients who have comorbidities or functional limitations...
2017: F1000Research
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