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https://www.readbyqxmd.com/read/28927054/methylation-of-stk11-promoter-is-a-risk-factor-for-tumor-stage-and-survival-in-clear-cell-renal-cell-carcinoma
#1
Fufu Zheng, Xiaoxu Yuan, Enjing Chen, Yunlin Ye, Xiaofei Li, Yuping Dai
Inactivation of tumor suppressor gene serine-threonine kinase 11 (STK11) in clear cell renal cell carcinoma (ccRCC) has been demonstrated; however, the mechanism of this inactivation remains to be investigated. To investigate whether epigenetic alteration plays a role in the inactivation of STK11 in RCC, the present study aimed to investigate the methylation status of the STK11 promoter and its association with tumor stage and survival in ccRCC patients. Paraffin-embedded specimens were obtained from 42 ccRCC patients...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28923700/venous-thromboembolism-risk-in-patients-with-locoregional-urothelial-tract-tumors
#2
Jorge D Ramos, Jonathan T Wingate, Roman Gulati, Elizabeth R Plimack, Lauren C Harshman, Thomas Powles, Simon J Crabb, Guenter Niegisch, Joaquim Bellmunt, Sylvain Ladoire, Ugo De Giorgi, Syed Hussain, Ajjai S Alva, Jack Baniel, Neeraj Agarwal, Jonathan E Rosenberg, Ulka N Vaishampayan, Matthew D Galsky, Evan Y Yu
BACKGROUND: Venous thromboembolism (VTE) is common in cancer patients, but there is limited data on patients with urothelial tract tumors (UTT). We previously identified several associative factors for increased VTE rates in patients with metastatic UTT. In this study, we assessed the frequency, associative factors, and impact on survival of VTE in patients with locoregional UTT. METHODS: Patients with locoregional bladder, upper urinary tract, or urethral cancer were included in this multi-center study from 29 academic institutions...
August 24, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28918166/high-expression-of-cxc-chemokine-receptor-6-associates-with-poor-prognosis-in-patients-with-clear-cell-renal-cell-carcinoma
#3
Yuan Chang, Lin Zhou, Le Xu, Qiang Fu, Yuanfeng Yang, Zongming Lin, Jiejie Xu
PURPOSE: Accumulating evidence indicates that CXC chemokine receptor 6 (CXCR6) has a crucial role in cancer development and progression, however, its role in clear cell renal cell carcinoma (ccRCC) remains obscure. The aim of this study is to investigate the prognostic value of CXCR6 expression in patients with ccRCC following surgery. MATERIALS AND METHODS: This study retrospectively included 239 patients with ccRCC who underwent nephrectomy and had paraffin tissue available at a single center...
September 13, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28890005/-ablative-therapy-in-kidney-cancer-oncological-functional-perioperative-outcomes-and-cost
#4
P Mouracade, T Tricard, A Gangi, X Cathelineau, H Lang
INTRODUCTION: The incidence of kidney cancer has increased significantly over the past few decades presumably due to the increased use of imaging. The aim of this article is to describe contemporary outcomes of ablative therapy and to compare them to other therapeutic options in terms of oncological, functional, perioperative outcomes and cost. MATERIAL AND METHODS: We searched MEDLINE(®), Embase(®), using (MeSH) words; from January 2005 through May 2017, and we looked for all the studies...
September 7, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28875952/role-of-r-e-n-a-l-nephrometry-score-in-laparoscopic-partial-nephrectomy
#5
Hai-Jiang Zhou, Yong Yan, Jian-Zhong Zhang, Li-Rong Liang, Shu-Bin Guo
Background: Preoperative anatomical scoring system is conducive to comparison between treatment options and evaluation of postoperative outcomes in patients with small renal tumors. This study aimed to evaluate the clinical application efficacy of the R.E.N.A.L. nephrometry score (RNS) in predicting perioperative outcomes in patients with renal tumor who underwent laparoscopic partial nephrectomy (LPN). Methods: The clinical data of 139 patients with renal tumors who underwent LPN between 2009 and 2015 were collected and analyzed...
September 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28864844/checkpoint-inhibitors-the-new-treatment-paradigm-for-urothelial-bladder-cancer
#6
REVIEW
Heather Katz, Emnet Wassie, Mohamed Alsharedi
Bladder cancer is the most common malignancy involving the genitourinary system (Siegel et al. in CA Cancer J Clin, 66:7-30, 2016). In the USA, it is the fifth most common cancer and approximately 79,000 new cases will be diagnosed in 2017 (Siegel et al. in CA Cancer J Clin, 66:7-30, 2016). The mortality from bladder cancer is approximately 17,000 deaths each year (Siegel et al. in CA Cancer J Clin, 66:7-30, 2016). The incidence rate for bladder cancer is higher in men compared to women. Risk factors are predominantly related to tobacco smoking, although infection with Schistosoma haematobium is another risk factor in selected populations (Antoni et al...
September 1, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28835865/primitive-neuroectodermal-tumor-and-wegener-s-granulomatosis-of-the-kidney-a-curious-combination-of-two-rare-entities
#7
Rugvedita Parakh, Satyajeet Parakh, Maria Tretiakova
Wegener's granulomatosis (WG) is characterized by necrotizing polyangiitis involving the respiratory tract and kidneys. It causes segmental necrotizing glomerulonephritis in the kidneys. In rare cases, a renal pseudotumor may be seen because of the granulomatous process. Association of WG with renal malignancy, however, is very uncommon. We report a case of a patient who presented several years after being treated for WG with malignant hypertension and an infiltrating mass in the right kidney. The histopathology of radical nephrectomy specimen showed presence of primitive neuroectodermal tumor (PNET)...
2017: Case Reports in Urology
https://www.readbyqxmd.com/read/28828515/changes-in-perioperative-systolic-blood-pressure-in-percutaneous-renal-mass-cryoablation
#8
Sung Yoon Park, Young Taik Oh, Kyunghwa Han, Dae Chul Jung, Man Deuk Kim, Jong Yun Won
OBJECTIVES: To analyze changes in systolic blood pressure (SBP) in the perioperative period of percutaneous renal mass cryoablation and risk factors. METHODS: This retrospective study included 54 patients who underwent percutaneous renal cryoablation. SBP before ablation (pre-Tx), during ablation (intra-Tx), immediately after ablation (post-Tx), and before discharge (discharge) were measured using a BP cuff. The highest SBP during cryoablation was regarded as SBP at intra-Tx...
August 21, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28818550/perinephric-and-sinus-fat-invasion-in-stage-pt3a-tumors-managed-by-partial-nephrectomy
#9
Pascal Mouracade, Julien Dagenais, Jaya Sai Chavali, Onder Kara, Ryan J Nelson, Matthew J Maurice, Jeremy Reese, Brian I Rini, Jihad H Kaouk
INTRODUCTION: We evaluated the influence of perinephric fat invasion (PFI) compared with sinus fat invasion (SFI) on disease-free survival (DFS) and cancer-specific survival (CSS) after partial nephrectomy (PN) for stage pT3a renal cell carcinoma (RCC). MATERIALS AND METHODS: Data were recorded from the consecutive records of patients who had undergone underwent PN for cT1-T2 RCC from 2007 to 2016. Of these patients, 143 had stage pT3a with SFI or PFI found on final pathologic examination...
July 26, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28816298/-multiple-endoscopy-for-the-treatment-of-upper-urinary-tract-calculi-following-ileal-conduit-a-case-report-and-literature-review
#10
B Wang, J F Ye, L Zhao, H Bi, J Lu, L L Ma
Upper urinary tract calculi with infection is a quite difficult acute urologic emergency. And what is more, upper urinary tract obstruction after radical cystectomy following urinary diversion may be fatal in the vulnerable patients with this kind of situation. Postoperative anatomy and other factors affect the upper urinary tract calculi, and urinary tract infection greatly increased the risk. But it is particularly difficult to handle with patients with poor general condition and septic shock treatment, so how to optimize the selection program is worth further studying...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28797586/obesity-as-defined-by-waist-circumference-but-not-body-mass-index-is-associated-with-higher-renal-mass-complexity
#11
Laura A Bertrand, Lewis J Thomas, Peng Li, Claire M Buchta, Shannon K Boi, Rachael M Orlandella, James A Brown, Kenneth G Nepple, Lyse A Norian
OBJECTIVES: Obesity, typically defined as a body mass index (BMI)≥30kg/m(2), is an established risk factor for renal cell carcinoma (RCC) but is paradoxically linked to less advanced disease at diagnosis and improved outcomes. However, BMI has inherent flaws, and alternate obesity-defining metrics that emphasize abdominal fat are available. We investigated 3 obesity-defining metrics, to better examine the associations of abdominal fat vs. generalized obesity with renal tumor stage, grade, or R...
August 7, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28781110/association-of-race-and-margin-status-among-patients-undergoing-robotic-partial-nephrectomy-for-t1-renal-cell-carcinoma-results-from-a-population-based-cohort
#12
Victor S Chen, Robert Abouassaly, Christopher M Gonzalez, Alexander Kutikov, Marc C Smaldone, Neal J Meropol, Sarah P Psutka, Stephen B Williams, Rebecca O'Malley, Hillary M Sedlacek, Simon P Kim
OBJECTIVE: To assess the relationship of race and margin status among patients undergoing robotic partial nephrectomy (RPN) for T1 renal tumors from a contemporary population-based cohort. METHODS: Using the National Cancer Database, we identified patients with localized renal cell carcinoma (RCC) (clinical T1N0M0) who underwent RPN from 2010 to 2013. The primary outcome was positive surgical margins (PSM). Multivariable logistic regression analyses were used to assess the association between race and PSM adjusting for patient clinicopathologic and hospital factors...
August 3, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28775205/therapy-related-hematological-malignancies-after-peptide-receptor-radionuclide-therapy-with-177-lu-dota-octreotate-incidence-course-predicting-factors-in-patients-with-gep-nets
#13
Hendrik Bergsma, Kirsten van Lom, Mark Konijnenberg, Boen Kam, Jaap Teunissen, Wouter de Herder, Eric Krenning, Dik Kwekkeboom
Peptide Receptor Radionuclide Therapy (PRRT) may induce long-term toxicity to the bone marrow (BM). The aim of this study was to analyze persistent dysfunction of the hematopoietic system after PRRT with (177)Lu-DOTATATE in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Methods: The incidence and course of persistent hematological dysfunction (PHD) was analyzed in 274 (=GEP-NET) out of 367 patients with somatostatin receptor-positive tumors. PHD was defined as diagnosis of Myelodysplastic Syndrome (MDS), Acute Myeloid Leukemia (AML), Myeloproliferative Neoplasms (MPN), Myelodysplastic/Myeloproliferative neoplasms (MDS/MPN) or otherwise unexplained cytopenia (for more than 6 months)...
August 3, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28753848/impact-of-microscopic-wall-invasion-of-the-renal-vein-or-inferior-vena-cava-on-cancer-specific-survival-in-patients-with-renal-cell-carcinoma-and-tumor-thrombus-a-multi-institutional-analysis-from-the-international-renal-cell-carcinoma-venous-thrombus-consortium
#14
Oscar Rodriguez Faba, Estefania Linares, Derya Tilki, Umberto Capitanio, Christopher P Evans, Francesco Montorsi, Juan I Martínez-Salamanca, John Libertino, Paolo Gontero, Joan Palou
BACKGROUND: Microscopic vein invasion (MVI), with local destruction and invasion of the endothelium by tumor, is of controversial predictive value in renal cell carcinoma (RCC). OBJECTIVE: To assess the impact of venous extension and wall invasion in RCC on survival. DESIGN, SETTING, AND PARTICIPANTS: Data for 1023 RCC patients with vena cava thrombus treated with radical nephrectomy and complete tumor thrombectomy were collected within a prospectively maintained international consortium (1995-2012)...
February 9, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28751166/clinical-and-demographic-characteristics-among-patients-with-urothelial-carcinomas-of-the-upper-urinary-tract-and-bladder-in-taiwan
#15
Cheng-Huang Shen, Hung-Yi Chiou, Min-Che Tung, Chia-Chang Wu, Wei-Tang Kao, Yuan-Hung Wang, Guang-Dar Juang
BACKGROUND: Urothelial carcinoma (UC) is derived from the urothelium of the urinary tract, and includes cancers of the bladder, renal pelvis and ureter. The aim of this study was to investigate the clinical and demographic features among patients with bladder cancer and urothelial carcinoma of the upper urinary tract (UTUC) in Taiwan. METHODS: The present study recruited a total of 736 histopathologically confirmed UC cases, which consisted of 470 bladder cancer and 266 UTUC between September 1998 and December 2009...
July 24, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28733204/the-polymorphism-xrcc1-arg194trp-and-8-hydroxydeoxyguanosine-increased-susceptibility-to-arsenic-related-renal-cell-carcinoma
#16
Yu-Mei Hsueh, Ying-Chin Lin, Wei-Jen Chen, Chao-Yuan Huang, Horng-Sheng Shiue, Yeong-Shiau Pu, Chi-Hung Chen, Chien-Tien Su
This study was designed to explore the relationship between X-ray repair cross-complementing group 1 (XRCC1) gene polymorphisms and renal cell carcinoma (RCC) and to investigate whether individuals with an XRCC1 risk genotype, a high level of 8-OHdG or a high urinary total arsenic concentration have a modified odds ratio (OR) of RCC. We recruited 180 RCC patients and 360 age- and sex-matched controls from a hospital-based pool. Image-guided biopsy or surgical resection of renal tumors was performed on RCC patients for pathological verification...
October 1, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28723504/active-surveillance-for-small-renal-masses-when-less-is-more
#17
REVIEW
Benjamin T Ristau, Alexander Kutikov, Robert G Uzzo, Marc C Smaldone
CONTEXT: A marked increase in incidentally detected small renal masses (SRMs) has occurred over the past decade. Active surveillance (AS) has emerged as an initial management option for these patients. OBJECTIVE: (1) To determine selection criteria, assess appropriate imaging modalities and surveillance frequencies, and define triggers for delayed intervention (DI) for patients on AS. (2) To describe oncologic outcomes for patients on AS protocols. EVIDENCE ACQUISITION: The PubMed database was queried for English language articles using the keywords "surveillance" and "renal mass" or "renal cell carcinoma" or "kidney cancer...
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723490/renal-preservation-and-partial-nephrectomy-patient-and-surgical-factors
#18
REVIEW
Lorenzo Marconi, Mihir M Desai, Vincenzo Ficarra, Francesco Porpiglia, Hendrik Van Poppel
CONTEXT: Optimization of the partial nephrectomy (PN) procedure in terms of preservation of functional outcomes is of special importance. OBJECTIVE: To review the most important patient and surgical factors that may influence the three elements that ultimately define the preservation of renal function (RF) after PN: preoperative RF, quantity of parenchyma preserved, and nephron recovery from ischemic insult. EVIDENCE ACQUISITION: A nonsystematic review of the literature was conducted...
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28721154/obesity-and-inflammation-the-linking-mechanism-and-the-complications
#19
Mohammed S Ellulu, Ismail Patimah, Huzwah Khaza'ai, Asmah Rahmat, Yehia Abed
Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state and oxidative stress. The increased level of interleukin 6 stimulates the liver to synthesize and secrete C-reactive protein. As a risk factor, inflammation is an imbedded mechanism of developed cardiovascular diseases including coagulation, atherosclerosis, metabolic syndrome, insulin resistance, and diabetes mellitus...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28721084/urinary-timp2%C3%A2-igfbp7-for-the-prediction-of-platinum-induced-acute-renal-injury
#20
Moritz Schanz, Anette Hoferer, Jing Shi, Mark Dominik Alscher, Martin Kimmel
INTRODUCTION: Platinum-based chemotherapy (PBC) is a potent antineoplastic treatment, but cisplatin nephrotoxicity is often the limiting factor. Identifying the patients who are at risk for developing platinum-induced renal injury is an important issue. We tested urinary TIMP2·IGFBP7, a new US Food and Drug Administration (FDA)-cleared test to assess the risk of acute kidney injury (AKI), in a cohort of patients with malignant neoplastic disease receiving PBC. PATIENTS AND METHODS: A total of 58 patients with malignant neoplastic disease were enrolled in this study, of whom 32 patients had both urine samples and subsequent serum creatinine values available for detecting AKI within 72 hours...
2017: International Journal of Nephrology and Renovascular Disease
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