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https://www.readbyqxmd.com/read/29331568/overall-survival-and-oncological-outcomes-after-partial-nephrectomy-and-radical-nephrectomy-for-ct2a-renal-tumors-a-collaborative-international-study-from-the-french-kidney-cancer-research-network-uroccr
#1
B Reix, J-C Bernhard, J-J Patard, P Bigot, A Villers, E Suer, N S Vuong, G Verhoest, Q Alimi, J-B Beauval, T Benoit, F-X Nouhaud, C Lenormand, N Hamidi, J Cai, M Eto, S Larre, A El Bakhri, G Ploussard, A Hung, N Koutlidis, A Schneider, J Carrouget, S Droupy, S Marchal, A Doerfler, S Seddik, T Matsugasumi, X Orsoni, A Descazeaud, C Pfister, K Bensalah, M Soulie, I Gill, V Flamand
BACKGROUND: Partial nephrectomy (PN) is recommended as first-line treatment for cT1 stage kidney tumors because of a better renal function and probably a better overall survival than radical nephrectomy (RN). For larger tumors, PN has a controversial position due to lack of evidence showing good cancer control. The aim of this study was to compare the results of PN and RN in cT2a stage on overall survival and oncological results. METHOD: A retrospective international multicenter study was conducted in the frame of the French kidney cancer research network (UroCCR)...
January 10, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29330720/dialysis-increases-the-risk-of-bladder-recurrence-in-patients-with-upper-tract-urothelial%C3%A2-cancer-a-population-based-study
#2
Ming-Yen Lin, Wei-Ming Li, Chun-Nung Huang, Huei-Lan Lee, Sheng-Wen Niu, Li-Tzong Chen, Wen-Jeng Wu, Shang-Jyh Hwang
BACKGROUND: The relation of dialysis to tumor recurrence in patients with upper tract urothelial cancer (UTUC) is unknown; however, a limited number of small-scale studies suggest that patients with renal diseases prior to UTUC are more likely to exhibit bladder recurrence. We performed a population-based analysis to determine the effect of dialysis on bladder recurrence for patients with UTUC. METHODS: This retrospective cohort study included patients diagnosed with UTUC (2002-2007) from the Taiwan National Cancer Registry and divided them into two groups-dialysis and non-dialysis groups...
January 12, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29311016/the-development-of-brain-metastases-in-patients-with-renal-cell-carcinoma-epidemiologic-trends-survival-and-clinical-risk-factors-using-a-population-based-cohort
#3
Maxine Sun, Guillermo De Velasco, Priscilla K Brastianos, Ayal A Aizer, Allison Martin, Raphael Moreira, Paul L Nguyen, Quoc-Dien Trinh, Toni K Choueiri
BACKGROUND: The incidence of brain metastases (BM) in patients with renal cell carcinoma (RCC) is hypothesized to have increased in the last 2 decades. OBJECTIVE: To define incidence trends according to patient and clinical characteristics, to identify risk factors, and to describe outcomes of patients with BM for RCC. DESIGN, SETTING, AND PARTICIPANTS: Patients diagnosed with RCC between the years 2010 and 2013 within the Surveillance, Epidemiology, and End Results database...
January 5, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29302841/prognostic-value-of-the-glasgow-prognostic-score-for-patients-with-metastatic-renal-cell-carcinoma-treated-by-cytoreductive-nephrectomy
#4
Hironori Fukuda, Toshio Takagi, Tsunenori Kondo, Kazuhiko Yoshida, Satoru Shimizu, Yoji Nagashima, Kazunari Tanabe
BACKGROUND: The aim of the present study was to evaluate the prognostic significance of the Glasgow Prognostic Score (GPS) in metastatic renal cell carcinoma (mRCC) patients treated by cytoreductive nephrectomy (CN), and the accuracy of the GPS as a prognostic factor. METHODS: We retrospectively analyzed the data of patients who underwent CN for mRCC between March 1984 and August 2015. In accordance with the GPS criteria, the patients were classified into three groups: GPS 0: C-reactive protein (CRP) ≤ 1...
January 5, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29284123/conversion-of-robot-assisted-partial-nephrectomy-to-radical-nephrectomy-a-prospective-multi-institutional-study
#5
Sohrab Arora, Brian Chun, Rajesh K Ahlawat, Ronney Abaza, James Adshead, James R Porter, Benjamin Challacombe, Prokar Dasgupta, Giorgio Gandaglia, Daniel A Moon, T B Yuvaraja, Umberto Capitanio, Alessandro Larcher, Francesco Porpiglia, Alexander Mottrie, Mahendra Bhandari, Craig Rogers
OBJECTIVES: To assess the incidence, and factors affecting conversion from robot-assisted partial nephrectomy (RAPN) to radical nephrectomy. METHODS: Between November 2014 and February 2017, 501 patients underwent attempted RAPN by 22 surgeons at 14 centers in nine countries within the Vattikuti Collaborative Quality Initiative database. Patients were permanently logged for RAPN prior to surgery and were analysed on an intention-to-treat basis. Multivariable logistic regression with backward stepwise selection of variables was done to assess the factors associated with conversion to radical nephrectomy...
December 25, 2017: Urology
https://www.readbyqxmd.com/read/29278921/management-of-hyperuricemia-through-dietary-polyphenols-as-a-natural-medicament-a-comprehensive-review
#6
Arshad Mehmood, Lei Zhao, Chengtao Wang, Muhammad Nadeem, Ali Raza, Nawazish Ali, Amjad Abbas Shah
Hyperuricemia, a condition due to high serum uric acid level and is notorious to health. It is considered to be a potent risk factor for gout and dramatically associated in the development of many chronic diseases such as malignant tumor, cardiovascular disorders and renal failure. Modern innovative medicinal and therapeutic interventions are underlying these days to combat hyperuricemia. Previously reported studies revealed the significant impact of dietary polyphenols (e.g. anthocyanins, phenolic acids, flavonoids etc...
December 26, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29238179/role-of-poly-adp-ribose-polymerase-1-and-cytokines-in-acute-renal-injury-in-elderly-chinese-patients-with-diabetes-mellitus
#7
Li Cao, Yan Liu, Li Zhang, Yanfei Wei
Objective: The primary objective of this study was to evaluate whether the polymorphism of poly (ADP-ribose) polymerase-1 (PARP-1) is involved as a potential risk factor in the development of acute renal injury in elderly Chinese patients with diabetes mellitus. Subjects and methods: In this pilot study, diabetic patients of either gender (aged ≥65 years) with a confirmed diagnosis of acute renal injury and individuals with no clinical symptoms of acute renal injury were enrolled at Nanxishan Hospital of Guangxi Zhuang Autonomous Region, China...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29237205/-how-does-diabetes-mellitus-influence-early-postoperative-results-and-survival-in-rectal-cancer
#8
Björn Gebauer, Frank Meyer, Henry Ptok, Ralf Steinert, Ronny Otto, Hans Lippert, Ingo Gastinger
Introduction Aim of this study was to investigate the influence of diabetes mellitus (DM) onto the early postoperative and long-term oncosurgical outcome after surgery for rectal cancer using data prospectively obtained in a representative number of patients. Methods Data (using a registration form of 68 items) from the ongoing multicenter observational study "rectal cancer (primary tumor) - elective surgery" on Quality Assurance was used including years 2008 to 2011. A voluntary and frequent follow-up was done to gain long-term data...
December 13, 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29221641/p53-expression-in-patients-with-renal-cell-carcinoma-correlates-with-a-higher-probability-of-disease-progression-and-increased-cancer-specific-mortality-after-surgery-but-does-not-enhance-the-predictive-accuracy-of-robust-outcome-models
#9
Laura Morshaeuser, Matthias May, Maximilian Burger, Wolfgang Otto, Georg C Hutterer, Martin Pichler, Tobias Klatte, Peter Wild, Lorenz Buser, Sabine Brookman-May
OBJECTIVE: Due to lacking external validation, molecular biomarkers are currently not applied for risk-stratification of patients with localized renal cell carcinoma. The objective of this study was to externally validate a molecular multi-marker panel included in a previously proposed prognostic nomogram for the prediction of postoperative disease-free survival. METHODS AND MATERIALS: Besides pathologic tumor stage (pT) and ECOG-Performance Status, the nomogram includes 5 molecular markers (Ki-67, p53, VEGFR-1 endothelial or epithelial, and VEGF-D epithelial)...
December 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29215458/recurrence-of-renal-cell-cancer-after-renal-transplantation-in-a-multicenter-french-cohort
#10
Noëlle Cognard, Dany Anglicheau, Philippe Gatault, Sophie Girerd, Marie Essig, Bruno Hurault de Ligny, Yann Le Meur, Franck Le Roy, Cyril Garrouste, Antoine Thierry, Charlotte Colosio, Joseph Rivalan, Johnny Sayegh, Gabriel Choukroun, Bruno Moulin, Sophie Caillard
BACKGROUND: Renal cancer accounts for 3% of adult malignancies; renal cell carcinoma (RCC) represents 80% of all renal cancers, and is characterized by late recurrences. Recurrences after kidney transplantation are associated with a high mortality rate. We aimed to determine if recurrences are linked to tumor characteristics and to delays between diagnosis and transplantation. METHODS: We retrospectively analyzed data from French kidney-transplanted patients with medical histories of pre-transplant renal cancer, focusing on the most common histological subtypes: clear cell and papillary cancers...
December 5, 2017: Transplantation
https://www.readbyqxmd.com/read/29211398/the-effect-of-ast-alt-de-ritis-ratio-on-survival-and-its-relation-to-tumor-histopathological-variables-in-patients-with-localized-renal-cell-carcinoma
#11
Lütfi Canat, Hasan Anil Ataly, Samir Agalarov, Ilter Alkan, Fatih Alturende
PURPOSE: To assess the relationship between De Ritis (aspartate aminotransaminase [AST]/Alanine aminotransaminase [ALT]) ratio and pathological variables and whether it is an independent prognostic factor. MATERIALS AND METHODS: We analyzed 298 consecutive patients who underwent radical or partial nephrectomy for non-metastatic renal cell carcinoma (RCC) between 2006 and 2015. The association between De Ritis ratio and pathological variables including tumor size, presence of renal vein invasion, vena cava invasion, renal capsule infiltration, Gerota fascia invasion, renal sinus involvement, renal pelvic invasion, angiolymphatic invasion, adrenal gland involvement, lymph node involvement, tumor necrosis, and Fuhrman's grade was tested...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29207011/astragaloside-iv-prevents-kidney-injury-caused-by-iatrogenic-hyperinsulinemia-in-a-streptozotocin%C3%A2-induced-diabetic-rat-model
#12
Ke-Qiang He, Wei-Zu Li, Xiao-Qing Chai, Yan-Yan Yin, Yan Jiang, Wei-Ping Li
Diabetic patients are able to manage their blood glucose with exogenous insulin but, ultimately, remain at risk of diabetic nephropathy (DN). Long‑term use of insulin may lead to iatrogenic hyperinsulinemia, which has been suggested to cause kidney injury. However, there are no effective interventions for iatrogenic hyperinsulinemia leading to kidney damage. In the present paper, the hypothesis that astragaloside IV (AS‑IV), a novel saponin purified from Astragalus membranaceus (Fisch) Bunge, may prevent DN in iatrogenic hyperinsulinemic diabetic rats through antioxidative and anti‑inflammatory mechanisms was investigated...
November 17, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29189567/transfusion-of-red-blood-cells-stored-more-than-28-days-is-associated-with-increased-morbidity-following-spine-surgery
#13
Taylor E Purvis, C Rory Goodwin, Camilo A Molina, Steven M Frank, Daniel M Sciubba
STUDY DESIGN: Retrospective study. OBJECTIVE: To describe the association between storage duration of packed red blood cells (PRBCs) and perioperative adverse events in patients undergoing spine surgery at a tertiary care center. SUMMARY OF BACKGROUND DATA: Despite retrospective studies that have shown that longer PRBC storage duration worsens patient outcomes, randomized clinical trials have found no difference in outcomes. However, no studies have examined the impact of giving the oldest blood (28 days-old or more) on morbidity within spine surgery...
November 17, 2017: Spine
https://www.readbyqxmd.com/read/29188298/adjuvant-sandwich-chemotherapy-plus-radiotherapy-vs-adjuvant-chemotherapy-alone-for-locally-advanced-bladder-cancer-after-radical-cystectomy-a-randomized-phase-2-trial
#14
Mohamed S Zaghloul, John P Christodouleas, Andrew Smith, Ahmed Abdallah, Hany William, Hussein M Khaled, Wei-Ting Hwang, Brian C Baumann
Importance: Locoregional failure for patients with locally advanced bladder cancer (LABC) after radical cystectomy (RC) is common even with chemotherapy and is associated with high morbidity and mortality. Adjuvant radiotherapy (RT) can decrease locoregional failure but has not been studied in the chemotherapy era. Objective: To investigate if adjuvant sequential RT plus chemotherapy can improve locoregional recurrence-free survival (LRFS) compared with adjuvant chemotherapy alone...
November 29, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29186296/adjuvant-therapy-in-renal-cell-carcinoma-does-higher-risk-for-recurrence-improve-the-chance-for-success
#15
R A Figlin, B C Leibovich, G D Stewart, S Negrier
The success of targeted therapies, including inhibitors of the vascular endothelial growth factor pathway or the mammalian target of rapamycin, in the treatment of metastatic renal cell carcinoma (RCC) led to interest in testing their efficacy in the adjuvant setting. Results from the first trials are now available with other studies due to report imminently. This review provides an overview of adjuvant targeted therapy in RCC, including interpretation of currently available conflicting data and future direction of research...
November 24, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29180877/clinical-significance-of-cmtm4-expression-in-hepatocellular-carcinoma
#16
Chunhua Bei, Ying Zhang, Riming Wei, Xiaonian Zhu, Zhigang Wang, Wen Zeng, Qiuyue Chen, Shengkui Tan
CMTM4 is the most conserved member of chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family on chromosome 16q22.1, a locus that harbors a number of tumor-suppressor genes. In previous studies, CMTM4 was reported to be downregulated and exhibited tumor-suppressor activities by regulating cell growth and cell cycle in clear cell renal cell carcinoma. However, its roles in tumorigenesis of hepatocellular carcinoma (HCC) remain poorly studied. This study first investigated the expression of CMTM4 in HCC, and then examined the association between the expression of CMTM4 with the clinicopathological features and prognosis of HCC patients...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29180299/initial-imaging-for-pediatric-renal-tumors-an-opportunity-for-improvement
#17
Amanda F Saltzman, Alonso Carrasco, Jason Weinman, Mariana L Meyers, Nicholas G Cost
PURPOSE: Current Children's Oncology Group studies on children with renal malignancy focus on minimizing side effects with a goal of decreasing long term complications. The goal of the present study is to evaluate the patterns of initial imaging in children with renal tumors. MATERIALS & METHODS: We retrospectively reviewed records of 122 patients treated for renal tumors at our institution from 2005 to 2016. Ideal imaging was defined as cross-sectional imaging of C/A/P in one setting without any additional ionizing radiation exposing scans...
November 24, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29170076/association-of-interleukin-6-with-aortic-stiffness-in%C3%A2-end-stage-renal-disease
#18
Marie-Pier Desjardins, Aboubacar Sidibé, Catherine Fortier, Fabrice Mac-Way, Karine Marquis, Sacha De Serres, Richard Larivière, Mohsen Agharazii
Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Aortic stiffness, a nontraditional risk factor, is associated with high rate of mortality in CKD. Using a CKD animal model with medial vascular calcification, we previously reported increased mRNA expression of interleukin-6 (IL-6), tumor necrosis factor (TNF), and interleukin-1β (IL-1β) in calcified aorta. The aim of the study was to investigate the association between IL-6, TNF, IL-1β, and aortic stiffness in end-stage renal disease patients...
October 13, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29170016/-sporadic-kidney-cancer-of-young-subjects-study-of-the-clinical-and-pathological-features-of-a-bicentric-cohort
#19
J Cohen, M O Timsit, D Zerbib, M Rouprêt, V Verkarre, E Comperat, A Mejean, M O Bitker
INTRODUCTION: The epidemiology of kidney cancer is evolving with a net increase in the incidence of renal tumors, globally, and in young people in particular. OBJECTIVE: To evaluate the incidence and clinical and pathological characteristics of sporadic renal tumors in young subjects and their risk factors. MATERIAL AND METHODS: A retrospective study aimed at collecting clinical, epidemiological and anatomopathological information from the 118 patients aged 18 to 40 treated for a sporadic kidney tumor in two Parisian university hospital centers between 2003 and 2013...
November 20, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/29169846/pbrm1-and-vhl-expression-correlate-in-human-clear-cell-renal-cell-carcinoma-with-differential-association-with-patient-s-overall-survival
#20
Anica Högner, Hans Krause, Burkhard Jandrig, Mumtaz Kasim, Tom Florian Fuller, Martin Schostak, Andreas Erbersdobler, Andreas Patzak, Ergin Kilic
OBJECTIVE: To identify the clinicopathological association of PBRM1 (Polybromo-1 gene) and VHL (von Hippel-Lindau gene) expression at mRNA and protein levels in clear cell renal cell carcinoma (ccRCC) and its role in tumor progression. PATIENTS AND METHODS: Immunohistochemical analysis, Western blotting and qPCR analysis of PBRM1 and VHL were performed on fresh-frozen ccRCC and adjacent normal tissue obtained from 70 patients who underwent radical nephrectomy. In addition, a tissue microarray (TMA) from specimens of 326 ccRCC patients was used to evaluate the effect of loss of PBRM1 and VHL immunohistological expression on clinicopathological features as well as patient survival...
November 20, 2017: Urologic Oncology
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