Read by QxMD icon Read

journal clinical micro

L Håglin, I Johansson, L Forsgren, L Bäckman
BACKGROUND/OBJECTIVES: To investigate whether vitamin-B density in the diet 2-8 years before diagnosis is associated with olfactory function at the time of diagnosis. SUBJECTS/METHODS: This prospective nested case-control study included patients with Parkinson's disease (PD), multiple system atrophy and progressive supranuclear paralysis identified between 2004 and 2009 in the county of Västerbotten in northern Sweden. The case database (NYPUM study; Newly Diagnosed Parkinson in Umeå; n=147) was cross-linked to the Northern Sweden Health and Disease Study (NSHDS)...
October 5, 2016: European Journal of Clinical Nutrition
Ritika Kapoor, Wei Chuen Tan-Koi, Yik-Ying Teo
Pharmacogenomics has been lauded as an important innovation in clinical medicine as a result of advances in genomic science. As one of the cornerstones in precision medicine, the vision to determine the right medication in the right dosage for the right treatment with the use of genetic information has not exactly materialised, and few genetic tests have been implemented as the standard of care in health systems worldwide. Here we review the findings from a SWOT analysis to examine the strengths, weaknesses, opportunities and threats around the role of pharmacogenetics in public health and clinical health care, at the micro, meso and macro levels corresponding to the perspectives of the individuals (scientists, patients and physicians), the health-care institutions and the health systems, respectively...
August 31, 2016: European Journal of Human Genetics: EJHG
F N Facio, M F Facio, L F Spessoto, D Pessutti, L O Reis, S G Campos, S Taboga
The aim of this study was to investigate the effect of the anti-inflammatory and anti-fibrotic actions of ANX1 on erectile function (EF). Forty-eight male Wistar rats were randomly distributed into four equal groups: one group (sham operation-control) and three groups (bilateral cavernous nerve (CN) crush injury). Crush injury groups were treated prior to injury with an intravascular injection of either ANX1 (50 or 100 μg kg(-1)) or vehicle. EF was assessed by CN electrical stimulation at 2 and 7 days after CN injury with histomorphometric and immunohistochemical analysis...
August 25, 2016: International Journal of Impotence Research
René Rodríguez-Gutiérrez, Victor M Montori
BACKGROUND: We sought to determine the concordance between the accumulating evidence about the impact of tight versus less tight glycemic control in patients with type 2 diabetes mellitus since the publication of UKPDS (UK Prospective Diabetes Study) in 1998 until 2015 with the views about that evidence published in journal articles and practice guidelines. METHODS AND RESULTS: We searched in top general medicine and specialty journals for articles referring to glycemic control appearing between 2006 and 2015 and identified the latest practice guidelines...
September 2016: Circulation. Cardiovascular Quality and Outcomes
Maria Fusaro, Claudia D'Alessandro, Marianna Noale, Giovanni Tripepi, Mario Plebani, Nicola Veronese, Giorgio Iervasi, Sandro Giannini, Maurizio Rossini, Giovanni Tarroni, Sandro Lucatello, Alberto Vianello, Irene Santinello, Luciana Bonfante, Fabrizio Fabris, Stefania Sella, Antonio Piccoli, Agostino Naso, Daniele Ciurlino, Andrea Aghi, Maurizio Gallieni, Adamasco Cupisti
BACKGROUND & AIMS: Vitamin K acts as a coenzyme in the γ-carboxylation of vitamin K-dependent proteins, including coagulation factors, osteocalcin, matrix Gla protein (MGP), and the growth arrest-specific 6 (GAS6) protein. Osteocalcin is a key factor for bone matrix formation. MGP is a local inhibitor of soft tissue calcification. GAS6 activity prevents the apoptosis of vascular smooth muscle cells. Few data on vitamin K intake in chronic kidney disease patients and no data in patients on a Mediterranean diet are available...
April 28, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Katy Schnitzler, Nigel Davies, Fiona Ross, Ruth Harris
Researchers have always recognised the importance of disseminating the findings of their work, however, recently the need to proactively plan and drive the impact of those findings on the wider society has become a necessity. Firstly, this is because funders require evidence of return from investment and secondly and crucially because national research assessments are becoming powerful determinants of future funding. In research studies associated with nursing, impact needs to be demonstrated by showing the effect on a range of stakeholders including service users, patients, carers, the nursing workforce and commissioners...
July 2016: International Journal of Nursing Studies
Nebil Yeşiloğlu, Gökhan Temiz, Murat Sarıcı, Kemalettin Yıldız, Hakan Şirinoğlu, Emre Güvercin, Ali Cem Akpınar, Gaye Taylan Filinte, Deniz Filinte
OBJECTIVES: In recent studies, collagen organization was blamed for the formation of capsular contracture which is still a challenging problem after silicone implant-based breast operations. In this study, effects of different concentrations of collagenase enzyme derived from Clostridium histolyticum on the capsular tissue formation around the silicone implants were investigated. The injectable form of collagenase has a routine clinical use in the treatment of both Dupuytren's and Peyronie's diseases...
February 2016: Aesthetic Plastic Surgery
C K Nikolaou, C R Hankey, M E J Lean
BACKGROUND/OBJECTIVES: There is limited evidence that prominent calorie labelling on out-of-home meals helps consumers reduce calorie intakes and avoid weight gain, but no evidence on its effects on macro- and micro-nutrients. The objective of this study was to assess the impact of prominent calorie labelling on energy, macro- and micro-nutrients. SUBJECTS/METHODS: Young adults in a catered residential setting were observed when choosing main meals over three study periods in fixed order in this observational study...
March 2016: European Journal of Clinical Nutrition
Leonard Pinchuk, Isabelle Riss, Juan F Batlle, Yasushi P Kato, John B Martin, Esdras Arrieta, Paul Palmberg, Richard K Parrish, Bruce A Weber, Yongmoon Kwon, Jean-Marie Parel
Glaucoma is the second leading cause of blindness with ∼70 million people worldwide who are blind from this disease. The currently practiced trabeculectomy surgery, the gold standard treatment used to stop the progression of vision loss, is rather draconian, traumatic to the patient and requires much surgical skill to perform. This article summarizes the more than 10-year development path of a novel device called the InnFocus MicroShunt®, which is a minimally invasive glaucoma drainage micro-tube used to shunt aqueous humor from the anterior chamber of the eye to a flap formed under the conjunctiva and Tenon's Capsule...
September 18, 2015: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Ola Spjuth, Maria Krestyaninova, Janna Hastings, Huei-Yi Shen, Jani Heikkinen, Melanie Waldenberger, Arnulf Langhammer, Claes Ladenvall, Tõnu Esko, Mats-Åke Persson, Jon Heggland, Joern Dietrich, Sandra Ose, Christian Gieger, Janina S Ried, Annette Peters, Isabel Fortier, Eco J C de Geus, Janis Klovins, Linda Zaharenko, Gonneke Willemsen, Jouke-Jan Hottenga, Jan-Eric Litton, Juha Karvanen, Dorret I Boomsma, Leif Groop, Johan Rung, Juni Palmgren, Nancy L Pedersen, Mark I McCarthy, Cornelia M van Duijn, Kristian Hveem, Andres Metspalu, Samuli Ripatti, Inga Prokopenko, Jennifer R Harris
A wealth of biospecimen samples are stored in modern globally distributed biobanks. Biomedical researchers worldwide need to be able to combine the available resources to improve the power of large-scale studies. A prerequisite for this effort is to be able to search and access phenotypic, clinical and other information about samples that are currently stored at biobanks in an integrated manner. However, privacy issues together with heterogeneous information systems and the lack of agreed-upon vocabularies have made specimen searching across multiple biobanks extremely challenging...
April 2016: European Journal of Human Genetics: EJHG
Simon C Langton Hewer, Alan R Smyth
BACKGROUND: Respiratory tract infection with Pseudomonas aeruginosa occurs in most people with cystic fibrosis. Once chronic infection is established, Pseudomonas aeruginosa is virtually impossible to eradicate and is associated with increased mortality and morbidity. Early infection may be easier to eradicate.This is an update of a Cochrane review first published in 2003, and previously updated in 2006 and 2009. OBJECTIVES: To determine whether antibiotic treatment of early Pseudomonas aeruginosa infection in children and adults with cystic fibrosis eradicates the organism, delays the onset of chronic infection, and results in clinical improvement...
2014: Cochrane Database of Systematic Reviews
Esmaeil Rezazadeh, Peyman Rezaei Hachesu, Aziz Rezapoor, Khaksarian Alireza
OBJECTIVES: Evidence Based Medicine (EBM) is proper and an efficient incorporation of the researches and experiences. This is study surveyed the attitudes, awareness, and practice of EBM with specific focus on the barriers to EBM, among clinical residents. METHODS: We conducted a cross sectional survey during September 2012 to February 2013 at the teaching hospitals of Mazandaran University of Medical Sciences among 81 clinical providers from different medical specialties...
February 2014: Journal of Evidence-based Medicine
Nicky Wilson, Catherine Pope, Lisa Roberts, Robert Crouch
Clinical practice guidelines produced by NICE - the National Institute for Health and Care Excellence - are seen as key mechanisms to regulate and standardise UK healthcare practice, but their development is known to be problematic, and their adoption and uptake variable. Examining what a guideline or health policy means to different audiences, and how it means something to those communities, provides new insight about interpretive discourses. In this paper we present a micro-analysis of the response of healthcare professionals to publication of a single NICE guideline in 2009 which proposed a re-organisation of professional services for chronic non-specific low back pain...
February 2014: Social Science & Medicine
Roberto Farina, Eriberto Bressan, Andrei Taut, Alessandro Cucchi, Leonardo Trombelli
AIM: To address the criticisms raised by Anitua et al. (European Journal of Oral Implantology, 6, 2013, 9-11) to the article "Plasma Rich in Growth Factors (PRGF) in Human Post-Extraction Sockets: an Histological and Histomorphometric Study.", recently published by Farina and colleagues (Clinical Oral Implants Research 2012; doi: 10.1111/clr.12033). METHODS: All the methodological aspects criticized in the letter by Anitua et al. were thoroughly reconsidered and discussed in a structured short communication...
October 2014: Clinical Oral Implants Research
Saina Attaran, Andrew Chukwuemeka, Prakash P Punjabi, Jon Anderson
A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed was 'do all patients with prosthetic valve endocarditis need surgery?' Seventeen papers were found using the reported search that represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. These studies compared the outcome and survival between surgically and non-surgically treated patients with prosthetic valve endocarditis...
December 2012: Interactive Cardiovascular and Thoracic Surgery
Joerg Meyle
PURPOSE: The objective of this review was to summarise current evidence with regard to the decontamination of implant surfaces by mechanical, chemical and physical methods in the presence of marginal bone loss arising from peri-implant infections. MATERIALS AND METHODS: A PubMed search identified studies and publications dealing with 'peri-implantitis', 'treatment', 'surface decontamination', 'laser application' 'air-abrasive treatment' and 'photodynamic therapy'...
2012: European Journal of Oral Implantology
Lil Breen, Nivedita Aswani
BACKGROUND: Pseudomonas aeruginosa is the commonest micro-organism associated with respiratory infections in cystic fibrosis. Retrospective studies have suggested that using an aggressive policy of intravenous anti-pseudomonal antibiotics at regular intervals, irrespective of symptoms, increases survival. OBJECTIVES: To determine whether there is evidence that an elective (regular) versus symptomatic intravenous antibiotic regimen is associated with an improvement in clinical status and survival rates in people with cystic fibrosis...
2012: Cochrane Database of Systematic Reviews
Brion Benninger, Taylor Delamarter
Introduction. This study investigated the importance of the "oblique popliteal ligament" (OPL), and challenges its alleged ligament status. The currently named OPL is indigenous to the distal semimembranosus (SMT); therefore, by definition is not a ligament inserting from bone to bone. Clinically, a muscle-tendon unit is different then a ligament regarding proprioception and surgery. Methods. Literature search was conducted on texts, journals and websites regarding the formation of the OPL. Dissection of 70 knees included macro analysis, harvesting OPL, distal SMT and LCL samples and performing immunohistochemistry to 16 knees with antibody staining to the OPL, distal SMT and LCL...
2012: Anatomy Research International
Lisa M Younk, Stephen N Davis
INTRODUCTION: Type 2 diabetes often involves derangements in lipid levels in addition to insulin resistance and diminishing insulin secretion. Colesevelam hydrochloride, a bile acid sequestrant (BAS), is approved for adjunctive therapy to diet and exercise for glycemic control in type 2 diabetes. In clinical studies in patients with type 2 diabetes, colesevelam, added to existing metformin, sulfonylurea or insulin therapy, reduced hemoglobin A(1c) (HbA(1c)) by a mean of 0.5% and low-density lipoprotein-cholesterol (LDL-C) by 13-17%...
April 2012: Expert Opinion on Drug Metabolism & Toxicology
J Robert Kelly, Paula Benetti, Patchanee Rungruanganunt, Alvaro Della Bona
OBJECTIVES: This paper attempts to provide critical perspectives on common in vitro research methodologies, including shear bond testing, wear testing, and load-to-failure tests. Origins of interest in high-quality laboratory data is reviewed, in vitro data is categorized into property and simulation protocols, and two approaches are suggested for establishing clinical validity. It is hoped that these insights will encourage further progress toward development of in vitro tests that are validated against clinical performance and/or by producing clinically validated failure or damage mechanisms...
January 2012: Dental Materials: Official Publication of the Academy of Dental Materials
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"