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journal clinical micro

Simon C Langton Hewer, Alan R Smyth
BACKGROUND: Respiratory tract infection with Pseudomonas aeruginosa occurs in most people with cystic fibrosis. Once chronic infection is established, Pseudomonas aeruginosa is virtually impossible to eradicate and is associated with increased mortality and morbidity. Early infection may be easier to eradicate.This is an update of a Cochrane review first published in 2003, and previously updated in 2006, 2009 and 2014. OBJECTIVES: To determine whether antibiotic treatment of early Pseudomonas aeruginosa infection in children and adults with cystic fibrosis eradicates the organism, delays the onset of chronic infection, and results in clinical improvement...
April 25, 2017: Cochrane Database of Systematic Reviews
Andrew S Dunn, Maria Reyna, Brian Radbill, Michael Parides, Claudia Colgan, Tobi Osio, Ari Benson, Nicole Brown, Joy Cambe, Margo Zwerling, Natalia Egorova, Harold Kaplan
BACKGROUND: Communication among team members within hospitals is typically fragmented. Bedside interdisciplinary rounds (IDR) have the potential to improve communication and outcomes through enhanced structure and patient engagement. OBJECTIVE: To decrease length of stay (LOS) and complications through the transformation of daily IDR to a bedside model. DESIGN: Controlled trial. SETTING: 2 geographic areas of a medical unit using a clinical microsystem structure...
March 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
Su-Shin Lee, Yu-Hao Huang, Tsung-Yin Lin, Chih-Kang Chou, Hidenobu Takahashi, Chung-Sheng Lai, Sin-Daw Lin, Tsai-Ming Lin
OBJECTIVE: Sunken temporal fossa appears oftentimes in Asians and resembles bad fortune that people wish to change. Numerous techniques and materials have been applied clinically for augmenting the sunken temporal fossa with variable results. The microautologous fat transplantation (MAFT) technique proposed by Lin et al in 2006 has demonstrated favorable results in facial rejuvenation. In the present study, the authors applied the MAFT technique with an innovative instrument in sunken temporal fossa and reported its results...
February 6, 2017: Journal of Craniofacial Surgery
Htoo Htoo Kyaw Soe, Adinegara Bl Abas, Nan Nitra Than, Han Ni, Jaspal Singh, Abdul Razzak Bin Mohd Said, Ifeyinwa Osunkwo
BACKGROUND: Sickle cell disease is a genetic chronic haemolytic and pro-inflammatory disorder. The clinical manifestations of sickle cell disease result from the presence of mutations on the beta globin genes that generate an abnormal haemoglobin product (called haemoglobin S) within the red blood cell. Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications (including painful vaso-occlusive crisis, osteomyelitis, osteonecrosis and osteoporosis)...
January 20, 2017: Cochrane Database of Systematic Reviews
L Jokubauskas, A Baltrušaitytė
Obstructive sleep apnoea syndrome (OSAS) is a clinical risk factor for sleep bruxism (SB). Both OSAS and SB are reported to be associated with sleep-related arousal reactions, although no clear causative link has been established. An electronic literature search was conducted of the MEDLINE, ScienceDirect, Wiley Online Library, SAGE Journals and EBSCOhost databases covering the period January 2006 and September 2016. Sequential screenings at the title, abstract and full-text levels were performed. The review included observational studies in the English language with a clearly established aim to assess the relationship between OSAS and SB using full-night PSG...
February 2017: Journal of Oral Rehabilitation
Andrew M Briggs, Madelynn Chan, Helen Slater
Models of Care (MoCs) are increasingly recognised as a system-level enabler to translate evidence for 'what works' into policy and, ultimately, clinical practice. MoCs provide a platform for a reform agenda in health systems by describing not only what care to deliver but also how to deliver it. Given the enormous burden of disease associated with musculoskeletal (MSK) conditions, system-level (macro) reform is needed to drive downstream improvements in MSK healthcare - at the health service (meso) level and at the clinical interface (micro) level...
June 2016: Best Practice & Research. Clinical Rheumatology
L Håglin, I Johansson, L Forsgren, L Bäckman
BACKGROUND/OBJECTIVES: To investigate whether vitamin-B density in the diet 2-8 years before diagnosis is associated with olfactory function at the time of diagnosis. SUBJECTS/METHODS: This prospective nested case-control study included patients with Parkinson's disease (PD), multiple system atrophy and progressive supranuclear paralysis identified between 2004 and 2009 in the county of Västerbotten in northern Sweden. The case database (NYPUM study; Newly Diagnosed Parkinson in Umeå; n=147) was cross-linked to the Northern Sweden Health and Disease Study (NSHDS)...
January 2017: European Journal of Clinical Nutrition
Ritika Kapoor, Wei Chuen Tan-Koi, Yik-Ying Teo
Pharmacogenomics has been lauded as an important innovation in clinical medicine as a result of advances in genomic science. As one of the cornerstones in precision medicine, the vision to determine the right medication in the right dosage for the right treatment with the use of genetic information has not exactly materialised, and few genetic tests have been implemented as the standard of care in health systems worldwide. Here we review the findings from a SWOT analysis to examine the strengths, weaknesses, opportunities and threats around the role of pharmacogenetics in public health and clinical health care, at the micro, meso and macro levels corresponding to the perspectives of the individuals (scientists, patients and physicians), the health-care institutions and the health systems, respectively...
December 2016: European Journal of Human Genetics: EJHG
F N Facio, M F Facio, L F Spessoto, D Pessutti, L O Reis, S G Campos, S Taboga
The aim of this study was to investigate the effect of the anti-inflammatory and anti-fibrotic actions of ANX1 on erectile function (EF). Forty-eight male Wistar rats were randomly distributed into four equal groups: one group (sham operation-control) and three groups (bilateral cavernous nerve (CN) crush injury). Crush injury groups were treated prior to injury with an intravascular injection of either ANX1 (50 or 100 μg kg(-1)) or vehicle. EF was assessed by CN electrical stimulation at 2 and 7 days after CN injury with histomorphometric and immunohistochemical analysis...
November 2016: International Journal of Impotence Research
René Rodríguez-Gutiérrez, Victor M Montori
BACKGROUND: We sought to determine the concordance between the accumulating evidence about the impact of tight versus less tight glycemic control in patients with type 2 diabetes mellitus since the publication of UKPDS (UK Prospective Diabetes Study) in 1998 until 2015 with the views about that evidence published in journal articles and practice guidelines. METHODS AND RESULTS: We searched in top general medicine and specialty journals for articles referring to glycemic control appearing between 2006 and 2015 and identified the latest practice guidelines...
September 2016: Circulation. Cardiovascular Quality and Outcomes
Maria Fusaro, Claudia D'Alessandro, Marianna Noale, Giovanni Tripepi, Mario Plebani, Nicola Veronese, Giorgio Iervasi, Sandro Giannini, Maurizio Rossini, Giovanni Tarroni, Sandro Lucatello, Alberto Vianello, Irene Santinello, Luciana Bonfante, Fabrizio Fabris, Stefania Sella, Antonio Piccoli, Agostino Naso, Daniele Ciurlino, Andrea Aghi, Maurizio Gallieni, Adamasco Cupisti
BACKGROUND & AIMS: Vitamin K acts as a coenzyme in the γ-carboxylation of vitamin K-dependent proteins, including coagulation factors, osteocalcin, matrix Gla protein (MGP), and the growth arrest-specific 6 (GAS6) protein. Osteocalcin is a key factor for bone matrix formation. MGP is a local inhibitor of soft tissue calcification. GAS6 activity prevents the apoptosis of vascular smooth muscle cells. Few data on vitamin K intake in chronic kidney disease patients and no data in patients on a Mediterranean diet are available...
April 28, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Katy Schnitzler, Nigel Davies, Fiona Ross, Ruth Harris
Researchers have always recognised the importance of disseminating the findings of their work, however, recently the need to proactively plan and drive the impact of those findings on the wider society has become a necessity. Firstly, this is because funders require evidence of return from investment and secondly and crucially because national research assessments are becoming powerful determinants of future funding. In research studies associated with nursing, impact needs to be demonstrated by showing the effect on a range of stakeholders including service users, patients, carers, the nursing workforce and commissioners...
July 2016: International Journal of Nursing Studies
Nebil Yeşiloğlu, Gökhan Temiz, Murat Sarıcı, Kemalettin Yıldız, Hakan Şirinoğlu, Emre Güvercin, Ali Cem Akpınar, Gaye Taylan Filinte, Deniz Filinte
OBJECTIVES: In recent studies, collagen organization was blamed for the formation of capsular contracture which is still a challenging problem after silicone implant-based breast operations. In this study, effects of different concentrations of collagenase enzyme derived from Clostridium histolyticum on the capsular tissue formation around the silicone implants were investigated. The injectable form of collagenase has a routine clinical use in the treatment of both Dupuytren's and Peyronie's diseases...
February 2016: Aesthetic Plastic Surgery
C K Nikolaou, C R Hankey, M E J Lean
BACKGROUND/OBJECTIVES: There is limited evidence that prominent calorie labelling on out-of-home meals helps consumers reduce calorie intakes and avoid weight gain, but no evidence on its effects on macro- and micro-nutrients. The objective of this study was to assess the impact of prominent calorie labelling on energy, macro- and micro-nutrients. SUBJECTS/METHODS: Young adults in a catered residential setting were observed when choosing main meals over three study periods in fixed order in this observational study...
March 2016: European Journal of Clinical Nutrition
Leonard Pinchuk, Isabelle Riss, Juan F Batlle, Yasushi P Kato, John B Martin, Esdras Arrieta, Paul Palmberg, Richard K Parrish, Bruce A Weber, Yongmoon Kwon, Jean-Marie Parel
Glaucoma is the second leading cause of blindness with ∼70 million people worldwide who are blind from this disease. The currently practiced trabeculectomy surgery, the gold standard treatment used to stop the progression of vision loss, is rather draconian, traumatic to the patient and requires much surgical skill to perform. This article summarizes the more than 10-year development path of a novel device called the InnFocus MicroShunt®, which is a minimally invasive glaucoma drainage micro-tube used to shunt aqueous humor from the anterior chamber of the eye to a flap formed under the conjunctiva and Tenon's Capsule...
January 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Ola Spjuth, Maria Krestyaninova, Janna Hastings, Huei-Yi Shen, Jani Heikkinen, Melanie Waldenberger, Arnulf Langhammer, Claes Ladenvall, Tõnu Esko, Mats-Åke Persson, Jon Heggland, Joern Dietrich, Sandra Ose, Christian Gieger, Janina S Ried, Annette Peters, Isabel Fortier, Eco J C de Geus, Janis Klovins, Linda Zaharenko, Gonneke Willemsen, Jouke-Jan Hottenga, Jan-Eric Litton, Juha Karvanen, Dorret I Boomsma, Leif Groop, Johan Rung, Juni Palmgren, Nancy L Pedersen, Mark I McCarthy, Cornelia M van Duijn, Kristian Hveem, Andres Metspalu, Samuli Ripatti, Inga Prokopenko, Jennifer R Harris
A wealth of biospecimen samples are stored in modern globally distributed biobanks. Biomedical researchers worldwide need to be able to combine the available resources to improve the power of large-scale studies. A prerequisite for this effort is to be able to search and access phenotypic, clinical and other information about samples that are currently stored at biobanks in an integrated manner. However, privacy issues together with heterogeneous information systems and the lack of agreed-upon vocabularies have made specimen searching across multiple biobanks extremely challenging...
April 2016: European Journal of Human Genetics: EJHG
Simon C Langton Hewer, Alan R Smyth
BACKGROUND: Respiratory tract infection with Pseudomonas aeruginosa occurs in most people with cystic fibrosis. Once chronic infection is established, Pseudomonas aeruginosa is virtually impossible to eradicate and is associated with increased mortality and morbidity. Early infection may be easier to eradicate.This is an update of a Cochrane review first published in 2003, and previously updated in 2006 and 2009. OBJECTIVES: To determine whether antibiotic treatment of early Pseudomonas aeruginosa infection in children and adults with cystic fibrosis eradicates the organism, delays the onset of chronic infection, and results in clinical improvement...
2014: Cochrane Database of Systematic Reviews
Esmaeil Rezazadeh, Peyman Rezaei Hachesu, Aziz Rezapoor, Khaksarian Alireza
OBJECTIVES: Evidence Based Medicine (EBM) is proper and an efficient incorporation of the researches and experiences. This is study surveyed the attitudes, awareness, and practice of EBM with specific focus on the barriers to EBM, among clinical residents. METHODS: We conducted a cross sectional survey during September 2012 to February 2013 at the teaching hospitals of Mazandaran University of Medical Sciences among 81 clinical providers from different medical specialties...
February 2014: Journal of Evidence-based Medicine
Nicky Wilson, Catherine Pope, Lisa Roberts, Robert Crouch
Clinical practice guidelines produced by NICE - the National Institute for Health and Care Excellence - are seen as key mechanisms to regulate and standardise UK healthcare practice, but their development is known to be problematic, and their adoption and uptake variable. Examining what a guideline or health policy means to different audiences, and how it means something to those communities, provides new insight about interpretive discourses. In this paper we present a micro-analysis of the response of healthcare professionals to publication of a single NICE guideline in 2009 which proposed a re-organisation of professional services for chronic non-specific low back pain...
February 2014: Social Science & Medicine
Roberto Farina, Eriberto Bressan, Andrei Taut, Alessandro Cucchi, Leonardo Trombelli
AIM: To address the criticisms raised by Anitua et al. (European Journal of Oral Implantology, 6, 2013, 9-11) to the article "Plasma Rich in Growth Factors (PRGF) in Human Post-Extraction Sockets: an Histological and Histomorphometric Study.", recently published by Farina and colleagues (Clinical Oral Implants Research 2012; doi: 10.1111/clr.12033). METHODS: All the methodological aspects criticized in the letter by Anitua et al. were thoroughly reconsidered and discussed in a structured short communication...
October 2014: Clinical Oral Implants Research
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