keyword
https://read.qxmd.com/read/38535494/xenobiotics-triggering-acute-intermittent-porphyria-and-their-effect-on-mouse-brain-respiratory-complexes
#1
JOURNAL ARTICLE
Johanna Romina Zuccoli, María Del Carmen Martínez, Pablo Vallecorsa, Ana María Buzaleh
Heme enzyme dysfunction causes a group of diseases called porphyrias. Particularly, a decrease in porphobilinogen deaminase, involved in the third step of heme biosynthesis, leads to acute intermittent porphyria (AIP). Considering our previous works demonstrating the multiplicity of brain metabolisms affected by porphyrinogenic agents, this study aimed to elucidate whether they cause any alteration on the mitochondrial respiratory chain. The activities of respiratory chain complexes (I to IV) were measured in encephalon mitochondria of CF1 male mice receiving volatile anesthetics: isoflurane (2 mL/kg) and sevoflurane (1...
February 27, 2024: Journal of Xenobiotics
https://read.qxmd.com/read/38535302/5-ala-dta-6-and-nitrogen-mitigate-nacl-stress-by-promoting-photosynthesis-and-carbon-metabolism-in-rice-seedlings
#2
JOURNAL ARTICLE
Yaxin Wang, Chaolu Tan, Yinghao Li, Fengyan Meng, Youwei Du, Shuyu Zhang, Wenxin Jiang, Naijie Feng, Liming Zhao, Dianfeng Zheng
A large number of dead seedlings can occur in saline soils, which seriously affects the large-scale cultivation of rice. This study investigated the effects of plant growth regulators (PGRs) and nitrogen application on seedling growth and salt tolerance ( Oryza sativa L.), which is of great significance for agricultural production practices. A conventional rice variety, "Huang Huazhan", was selected for this study. Non-salt stress treatments included 0% NaCl (CK treatment), CK + 0.05 g N/pot (N treatment), CK + 40 mg·L-1 5-aminolevulinic acid (5-ALA) (A treatment), and CK + 30 mg·L-1 diethylaminoethyl acetate (DTA-6) (D treatment)...
February 27, 2024: Metabolites
https://read.qxmd.com/read/38528712/effect-of-photodynamic-therapy-with-5-aminolevulinic-acid-and-edta-2na-against-mixed-infection-of-methicillin-resistant-staphylococcus-aureus-and-pseudomonas-aeruginosa
#3
JOURNAL ARTICLE
Rie Teranishi, Toshiyuki Ozawa, Bunpei Katayama, Yu Shimojo, Nobuhisa Ito, Kunio Awazu, Daisuke Tsuruta
BACKGROUND: The increasing abundance of drug-resistant bacteria is a global threat. Photodynamic therapy is an entirely new, non-invasive method for treating infections caused by antibiotic-resistant strains. We previously described the bactericidal effect of photodynamic therapy on infections caused by a single type of bacterium. We showed that gram-positive and gram-negative bacteria could be killed with 5-aminolevulic acid and 410 nm light, respectively. However, clinically, mixed infections are common and difficult to treat...
March 2024: Photodermatology, Photoimmunology & Photomedicine
https://read.qxmd.com/read/38527661/photodynamic-therapy-combined-with-carbon-dioxide-laser-pretreatment-for-treatment-of-perifolliculitis-capitis-abscedens-et-suffodiens-a-case-report
#4
Jianhua Huang, Hongwei Wang
Perifolliculitis capitis abscedens et suffodiens (PCAS) is a refractory and recrudescent chronic inflammatory dermatosis of the scalp, which seriously affects the appearance and quality of life of patients. The treatment of PCAS is challenging, often leading to frustrating outcome. In this paper, we report a case of PCAS who received 20% 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with carbon dioxide (CO2) laser pretreatment. The skin lesions of this case showed complete clearance after 2 month, and there was no recurrence after 1 year of follow-up...
March 23, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38516394/advancement-of-fluorescent-aminopeptidase-probes-for-rapid-cancer-detection-current-uses-and-neurosurgical-applications
#5
REVIEW
Takenori Shimizu, Shota Tanaka, Yosuke Kitagawa, Yusuke Sakaguchi, Mako Kamiya, Shunsaku Takayanagi, Hirokazu Takami, Yasuteru Urano, Nobuhito Saito
Surgical resection is considered for most brain tumors to obtain tissue diagnosis and to eradicate or debulk the tumor. Glioma, the most common primary malignant brain tumor, generally has a poor prognosis despite the multidisciplinary treatments with radical resection and chemoradiotherapy. Surgical resection of glioma is often complicated by the obscure border between the tumor and the adjacent brain tissues and by the tumor's infiltration into the eloquent brain. 5-aminolevulinic acid is frequently used for tumor visualization, as it exhibits high fluorescence in high-grade glioma...
2024: Frontiers in Surgery
https://read.qxmd.com/read/38513809/assessing-field-cancerization-and-actinic-keratosis-using-ultraviolet-induced-fluorescence-dermatoscopy-after-the-application-of-5-aminolevulinic-acid-an-observational-study
#6
JOURNAL ARTICLE
Katarzyna Korecka, Adriana Polańska, Aleksandra Dańczak-Pazdrowska, Cristian Navarrete-Dechent
BACKGROUND: Actinic keratoses (AK) are one of the most frequent reasons for consultations in dermatology. Ultraviolet-induced fluorescence dermatoscopy (UVFD) is a new method that allows the assessment of lesions in a spectrum of light that originates from the fluorochromes emitting UV-excited luminescence. The aim of this study was to assess the UVFD features of AKs before PDT and their intensity in field cancerization and single lesions. METHODS: This retrospective study was conducted from June to November 2023...
March 19, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38513542/evaluation-of-the-potential-of-delta-aminolevulinic-acid-for-simultaneous-detection-of-bioburden-and-anti-microbial-photodynamic-therapy-of-mrsa-infected-wounds-in-swiss-albino-mice
#7
JOURNAL ARTICLE
Khageswar Sahu, Hemant Krishna, Rashmi Shrivastava, Anamitra Majumdar, Anupam Chowdhury, Sourabrata Chakraborty, Shovan Kumar Majumder
BACKGROUND: The dramatic increase of drug-resistant bacteria necessitates urgent development of platforms to simultaneously detect and inactivate bacteria causing wound infections, but are confronted with various challenges. Delta amino levulinic acid (ALA) induced protoporphyrin IX (PpIX) can be a promising modality for simultaneous bioburden diagnostics and therapeutics. Herein, we report utility of ALA induced protoporphyrin (PpIX) based simultaneous bioburden detection, photoinactivation and therapeutic outcome assessment in methicillin resistant Staphylococcus aureus (MRSA) infected wounds of mice...
March 15, 2024: Journal of Photochemistry and Photobiology. B, Biology
https://read.qxmd.com/read/38495756/plant-growth-regulators-mitigate-oxidative-damage-to-rice-seedling-roots-by-nacl-stress
#8
JOURNAL ARTICLE
Yaxin Wang, Li-Ming Zhao, Naijie Feng, Dianfeng Zheng, Xue Feng Shen, Hang Zhou, Wenxin Jiang, Youwei Du, Huimin Zhao, Xutong Lu, Peng Deng
The aim of this experiment was to investigate the effects of exogenous sprays of 5-aminolevulinic acid (5-ALA) and 2-Diethylaminoethyl hexanoate (DTA-6) on the growth and salt tolerance of rice ( Oryza sativa L.) seedlings. This study was conducted in a solar greenhouse at Guangdong Ocean University, where 'Huanghuazhan' was selected as the test material, and 40 mg/L 5-ALA and 30 mg/L DTA-6 were applied as foliar sprays at the three-leaf-one-heart stage of rice, followed by treatment with 0.3% NaCl (W/W) 24 h later...
2024: PeerJ
https://read.qxmd.com/read/38495031/5-aminolevulinic-acid-improves-cold-resistance-through-regulation-of-slmyb4-slmyb88-slgstu43-module-to-scavenge-reactive-oxygen-species-in-tomato
#9
JOURNAL ARTICLE
Zhengda Zhang, Luqiao Yuan, Jiao Dang, Yuhui Zhang, Yongshuai Wen, Yu Du, Yufei Liang, Ya Wang, Tao Liu, Tianlai Li, Xiaohui Hu
Cold stress severely affects the growth and quality of tomato. 5-Aminolevulinic acid (ALA) can effectively improve tomato's cold stress tolerance. In this study, a tomato glutathione S-transferase gene, SlGSTU43, was identified . Results showed that ALA strongly induced the expression of SlGSTU43 under cold stress . SlGSTU43 -overexpressing lines showed increased resistance to cold stress through an enhanced ability to scavenge reactive oxygen species. On the contrary, slgstu43 mutant lines were sensitive to cold stress, and ALA did not improve their cold stress tolerance...
March 2024: Horticulture Research
https://read.qxmd.com/read/38484742/cross-validation-of-metabolic-phenotypes-in-sars-cov-2-infected-subpopulations-using-targeted-liquid-chromatography-mass-spectrometry-lc-ms
#10
JOURNAL ARTICLE
Luke Whiley, Nathan G Lawler, Annie Xu Zeng, Alex Lee, Sung-Tong Chin, Maider Bizkarguenaga, Chiara Bruzzone, Nieves Embade, Julien Wist, Elaine Holmes, Oscar Millet, Jeremy K Nicholson, Nicola Gray
To ensure biological validity in metabolic phenotyping, findings must be replicated in independent sample sets. Targeted workflows have long been heralded as ideal platforms for such validation due to their robust quantitative capability. We evaluated the capability of liquid chromatography-mass spectrometry (LC-MS) assays targeting organic acids and bile acids to validate metabolic phenotypes of SARS-CoV-2 infection. Two independent sample sets were collected: (1) Australia: plasma, SARS-CoV-2 positive ( n = 20), noninfected healthy controls ( n = 22) and COVID-19 disease-like symptoms but negative for SARS-CoV-2 infection ( n = 22)...
March 14, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38477138/effectiveness-of-lapatinib-for-enhancing-5-aminolevulinic-acid-mediated-protoporphyrin-ix-fluorescence-and-photodynamic-therapy-in-human-cancer-cell-lines-with-varied-abcg2-activities
#11
JOURNAL ARTICLE
Richard Howley, Jordyn Olsen, Bin Chen
5-Aminolevulinic acid (ALA) is a prodrug for protoporphyrin IX (PpIX)-mediated photodynamic therapy (PDT) and fluorescence-guided tumor surgery. We previously reported that lapatinib, a repurposed ABCG2 inhibitor, enhanced ALA-induced PpIX fluorescence and PDT by blocking ABCG2-mediated PpIX efflux. In the present study, we evaluated how the variation in ABCG2 activities/protein levels affected tumor cell response to the enhancement of PpIX/PDT by lapatinib and Ko143, an ABCG2 tool inhibitor. ABCG2 activities and protein levels were determined in a panel of human cancer cell lines...
March 13, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38475902/application-of-fluorocarbon-nanoparticles-of-131-i-fulvestrant-as-a-targeted-radiation-drug-for-endocrine-therapy-on-human-breast-cancer
#12
JOURNAL ARTICLE
Li Zhi, Chen Cheng, Luo Jing, Peng Zhi-Ping, Yang Lu, Tian Yan, Wang Zhi-Gang, Yin Guo-Bing
BACKGROUND: Breast cancer is the most prevalent malignant tumor among women, with hormone receptor-positive cases constituting 70%. Fulvestrant, an antagonist for these receptors, is utilized for advanced metastatic hormone receptor-positive breast cancer. Yet, its inhibitory effect on tumor cells is not strong, and it lacks direct cytotoxicity. Consequently, there's a significant challenge in preventing recurrence and metastasis once cancer cells develop resistance to fulvestrant. METHOD: To address these challenges, we engineered tumor-targeting nanoparticles termed 131 I-fulvestrant-ALA-PFP-FA-NPs...
March 12, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38467338/comparison-of-5-ala-pdt-and-leep-of-cervical-squamous-intraepithelial-neoplasia-cin2-with-high-risk-human-papillomavirus-infection-in-childbearing-age-women-a-non-randomized-controlled-polit-study
#13
JOURNAL ARTICLE
Lili Wang, Xiaoli Liu, Junhua Zhang, Min Song, Hongli Liu, Ying Xu, Lihua Meng, Youzhong Zhang, Lin Jia
BACKGROUND: 5-Aminolevulinic acid-mediated photodynamic therapy (5-ALA-PDT) is a possible minimally-invasive treatment for high-grade cervical intraepithelial neoplasia (HSIL). The present study was carried out to assess the effect of 5-ALA-PDT and loop electrosurgical excision procedure (LEEP) in cervical squamous intraepithelial neoplasia (CIN2) combined with high-risk human papillomavirus (HR-HPV) infection. METHODS: In this study, 190 patients with CIN2 and HR-HPV infection were finally included...
March 9, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38463624/the-paradigm-change-from-reactive-medical-services-to-3pm-in-ischemic-stroke-a-holistic-approach-utilising-tear-fluid-multi-omics-mitochondria-as-a-vital-biosensor-and-ai-based-multi-professional-data-interpretation
#14
JOURNAL ARTICLE
Olga Golubnitschaja, Jiri Polivka, Pavel Potuznik, Martin Pesta, Ivana Stetkarova, Alena Mazurakova, Lenka Lackova, Peter Kubatka, Martina Kropp, Gabriele Thumann, Carl Erb, Holger Fröhlich, Wei Wang, Babak Baban, Marko Kapalla, Niva Shapira, Kneginja Richter, Alexander Karabatsiakis, Ivica Smokovski, Leonard Christopher Schmeel, Eleni Gkika, Friedemann Paul, Paolo Parini, Jiri Polivka
Worldwide stroke is the second leading cause of death and the third leading cause of death and disability combined. The estimated global economic burden by stroke is over US$891 billion per year. Within three decades (1990-2019), the incidence increased by 70%, deaths by 43%, prevalence by 102%, and DALYs by 143%. Of over 100 million people affected by stroke, about 76% are ischemic stroke (IS) patients recorded worldwide. Contextually, ischemic stroke moves into particular focus of multi-professional groups including researchers, healthcare industry, economists, and policy-makers...
March 2024: EPMA Journal
https://read.qxmd.com/read/38462517/a-case-of-hereditary-coproporphyria-in-which-the-patient-s-course-improved-after-the-discontinuation-of-givosiran
#15
JOURNAL ARTICLE
Nobuaki Ozaki, Yuri Hayashi, Atsushi Kiyota
Hereditary coproporphyria (HCP) is caused by a partial deficiency of coproporphyrinogen oxidase during heme biosynthesis. Givosiran is approved for the treatment of acute hepatic porphyria. We herein report the case of a 47-year-old woman with HCP. Monthly givosiran administration improved her subjective symptoms and reduced her δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels to the normal range. However, givosiran was discontinued after six months due to a decreased renal function. The patient's ALA and PBG levels remained within the normal ranges, and her HCP-related symptoms resolved more than 2 years after the discontinuation of givosiran...
March 11, 2024: Internal Medicine
https://read.qxmd.com/read/38457785/berberine-as-a-potential-enhancer-for-5-ala-mediated-fluorescence-in-glioblastoma-increasing-detectability-of-infiltrating-glioma-stem-cells-to-optimize-5-ala-guided-surgery
#16
JOURNAL ARTICLE
Yoshihiro Ohtsuka, Satoshi Suehiro, Akihiro Inoue, Takanori Ohnishi, Masahiro Nishikawa, Daisuke Yamashita, Hajime Yano, Mohammed E Choudhury, Saya Ozaki, Oltea Sampetrean, Hideyuki Saya, Hideaki Watanabe, Junya Tanaka, Takeharu Kunieda
OBJECTIVE: The prognosis of glioblastoma (GBM) correlates with residual tumor volume after surgery. In fluorescence-guided surgery, 5-aminolevulinic acid (ALA) has been used to maximize resection while avoiding neurological morbidity. However, not all tumor cells, particularly glioma stem cells (GSCs), display 5-ALA-mediated protoporphyrin IX (PpIX) fluorescence (5-ALA fluorescence). The authors searched for repositioned drugs that affect mitochondrial functions and energy metabolism, identifying berberine (BBR) as a potential enhancer of 5-ALA fluorescence...
March 8, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38452908/photodynamic-therapy-combined-with-antifungal-drugs-against-kerion-a-report-of-six-cases-and-literature-review
#17
Xiaoli Chen, Yujia Liang, Ziyu Guo, Ruiye Huang, Wenai Zheng, Weiwei Wu, Wen Li
Kerion, a severe manifestation of tinea capitis caused by dermatophytes, is a fungal skin disease primarily affecting children. This report discusses six cases of pediatric kerion that were successfully treated with a combination of photodynamic therapy (PDT) and antifungal agents. Additionally, we conducted a literature review, identifying and analyzing six published reports on kerion and tinea capitis. The characteristics and efficacies of these cases are summarized. In summary, early combination therapy and proactive pre-treatment interventions proved effective in maximizing therapeutic outcomes, reducing disease duration and minimizing adverse reactions such as cicatricial alopecia...
March 5, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38445882/carrier-free-amorphous-verteporfin-nanodrug-for-enhanced-photodynamic-cancer-therapy-and-brain-drug-delivery
#18
JOURNAL ARTICLE
John A Quinlan, Collin T Inglut, Payal Srivastava, Idrisa Rahman, Jillian Stabile, Brandon Gaitan, Carla Arnau Del Valle, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Baktiar Karim, Nina Connolly, Robert W Robey, Graeme F Woodworth, Michael M Gottesman, Huang-Chiao Huang
Glioblastoma (GBM) is hard to treat due to cellular invasion into functioning brain tissues, limited drug delivery, and evolved treatment resistance. Recurrence is nearly universal even after surgery, chemotherapy, and radiation. Photodynamic therapy (PDT) involves photosensitizer administration followed by light activation to generate reactive oxygen species at tumor sites, thereby killing cells or inducing biological changes. PDT can ablate unresectable GBM and sensitize tumors to chemotherapy. Verteporfin (VP) is a promising photosensitizer that relies on liposomal carriers for clinical use...
March 6, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38442799/clinical-efficacy-analysis-of-5-aminolevulinic-acid-photodynamic-therapy-for-vulvar-lichen-sclerosus
#19
JOURNAL ARTICLE
Zhongyu Qu, Xueyan Lin, Ming Liu, Jia Wang, Fei Wang, Bei Zhang, Liang Shen, Zhifeng Wang
OBJECTIVE: The purpose of this study is to analyze the efficacy of photodynamic therapy in the treatment of vulvar lichen sclerosus who do not respond to topical glucocorticoid therapy, analyze whether there are factors that affect the efficacy, and identify adverse reactions to the treatment. METHOD: This retrospective study included 42 patients with vulval lichen sclerosis treated with ALA-PDT. Basic data of all patients were collected, and the clinical symptoms and signs of the patients before treatment were evaluated...
March 3, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38438001/home-vs-clinic-based-daylight-photodynamic-therapy-with-5-aminolevulinic-acid-nanoemulsion-bf-200-ala-for-actinic-keratosis-a-randomized-single-blind-prospective-study
#20
JOURNAL ARTICLE
S Saenz-Guirado, A Ayen-Rodriguez, M Galvez-Moreno, J P Velasco-Amador, J M Llamas-Molina, R Ruiz-Villaverde, A Molina-Leyva
BACKGROUND: Daylight photodynamic therapy (DL-PDT) has become one of the most effective treatments for the resolution of actinic keratosis (AK) of Olsen grade 1 and 2. Generally, PDT it is carried out in a clinic setting, which involves the patient's and their caregivers commuting to the hospital as well as a significant use of resources to carry it out within the clinic setting. OBJECTIVES: To determine the efficacy and safety of a home-based treatment of AK with DL-PDT with the BF-200 ALA gel compared to a clinic-based setting...
March 2, 2024: Photodiagnosis and Photodynamic Therapy
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