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https://www.readbyqxmd.com/read/29225021/implications-of-core-and-hip-injuries-on-major-league-baseball-pitchers-on-the-disabled-list
#1
Nathan E Marshall, Toufic R Jildeh, Kelechi R Okoroha, Ankur Patel, Vasilios Moutzouros, Eric C Makhni
PURPOSE: To investigate the frequency of core and hip injuries in Major League Baseball (MLB) pitchers and their impact on performance, workload, and pitch type. METHODS: Demographic, performance data, and injury data were acquired for 330 MLB pitchers with 454 injuries placed on the disabled list (DL) from 2014 to 2015 seasons. Core and hip/groin injuries were analyzed in which injury year data were compared with career data and against other injury groups. RESULTS: Core injuries represented 14% of all injuries and hip/groin injuries represented 7%...
December 7, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29208716/direct-measurements-of-meltwater-runoff-on-the-greenland-ice-sheet-surface
#2
Laurence C Smith, Kang Yang, Lincoln H Pitcher, Brandon T Overstreet, Vena W Chu, Åsa K Rennermalm, Jonathan C Ryan, Matthew G Cooper, Colin J Gleason, Marco Tedesco, Jeyavinoth Jeyaratnam, Dirk van As, Michiel R van den Broeke, Willem Jan van de Berg, Brice Noël, Peter L Langen, Richard I Cullather, Bin Zhao, Michael J Willis, Alun Hubbard, Jason E Box, Brittany A Jenner, Alberto E Behar
Meltwater runoff from the Greenland ice sheet surface influences surface mass balance (SMB), ice dynamics, and global sea level rise, but is estimated with climate models and thus difficult to validate. We present a way to measure ice surface runoff directly, from hourly in situ supraglacial river discharge measurements and simultaneous high-resolution satellite/drone remote sensing of upstream fluvial catchment area. A first 72-h trial for a 63.1-km2 moulin-terminating internally drained catchment (IDC) on Greenland's midelevation (1,207-1,381 m above sea level) ablation zone is compared with melt and runoff simulations from HIRHAM5, MAR3...
December 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29192934/predicting-injury-in-professional-baseball-pitchers-from-delivery-mechanics-a-statistical-model-using-quantitative-video-analysis
#3
E Grant Sutter, Justin Orenduff, Will J Fox, Joshua Myers, Grant E Garrigues
Baseball pitching imposes significant stress on the upper extremity and can lead to injury. Many studies have attempted to predict injury through pitching mechanics, most of which have used laboratory setups that are often not practical for population-based analysis. This study sought to predict injury risk in professional baseball pitchers using a statistical model based on video analysis evaluating delivery mechanics in a large population. Career data were collected and video analysis was performed on a random sample of former and current professional pitchers...
November 30, 2017: Orthopedics
https://www.readbyqxmd.com/read/29191666/nepenthes-state-of-the-art-of-an-inspiring-plant-for-biotechnologists
#4
REVIEW
Sissi Miguel, Alain Hehn, Frédéric Bourgaud
Plant carnivory results from the adaptation of plants to their environment. The capture and digestion of preys, followed by their assimilation by the plant is a source of additional nutrients to overcome scarce nutrient in poor soils. Nepenthes are highly studied carnivorous plants and have developed a number of ecological traits which have attracted the attention of plant biologists. Multiple adaptive strategies developed by these plants make them a source of inspiration for many applications ranging from therapeutic treatments to biocontrol solution in agriculture...
November 27, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/29188284/vemurafenib-for-braf-v600-mutant-erdheim-chester-disease-and-langerhans-cell-histiocytosis-analysis-of-data-from-the-histology-independent-phase-2-open-label-ve-basket-study
#5
Eli L Diamond, Vivek Subbiah, A Craig Lockhart, Jean-Yves Blay, Igor Puzanov, Ian Chau, Noopur S Raje, Jurgen Wolf, Joseph P Erinjeri, Jean Torrisi, Mario Lacouture, Elena Elez, Ferran Martínez-Valle, Benjamin Durham, Maria E Arcila, Gary Ulaner, Omar Abdel-Wahab, Bethany Pitcher, Martina Makrutzki, Todd Riehl, José Baselga, David M Hyman
Importance: The histiocytic neoplasms Erdheim-Chester disease (ECD) and Langerhans cell histiocytosis (LCH) are highly enriched for BRAF V600 mutations and have been previously shown to be responsive to treatment with vemurafenib, an inhibitor of the BRAF V600 kinase. However, the long-term efficacy and safety of prolonged vemurafenib use in these patients are not defined. Here we analyze the final efficacy and safety data for vemurafenib in patients with ECD and LCH enrolled in the VE-BASKET study...
November 29, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29177104/environmental-proteomics-reveals-taxonomic-and-functional-changes-in-an-enriched-aquatic-ecosystem
#6
Amanda C Northrop, Rachel Brooks, Aaron M Ellison, Nicholas J Gotelli, Bryan A Ballif
Aquatic ecosystem enrichment can lead to distinct and irreversible changes to undesirable states. Understanding changes in active microbial community function and composition following organic-matter loading in enriched ecosystems can help identify biomarkers of such state changes. In a field experiment, we enriched replicate aquatic ecosystems in the pitchers of the northern pitcher plant, Sarracenia purpurea. Shotgun metaproteomics using a custom metagenomic database identified proteins, molecular pathways, and contributing microbial taxa that differentiated control ecosystems from those that were enriched...
October 2017: Ecosphere
https://www.readbyqxmd.com/read/29176651/exosomal-cargo-including-microrna-regulates-sensory-neuron-to-macrophage-communication-after-nerve-trauma
#7
Raffaele Simeoli, Karli Montague, Hefin R Jones, Laura Castaldi, David Chambers, Jayne H Kelleher, Valentina Vacca, Thomas Pitcher, John Grist, Hadil Al-Ahdal, Liang-Fong Wong, Mauro Perretti, Johnathan Lai, Peter Mouritzen, Paul Heppenstall, Marzia Malcangio
Following peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in dorsal root ganglia (DRG) sensory neurons. Here we show that DRG neuron cell bodies release extracellular vesicles, including exosomes containing miRs, upon activity. We demonstrate that miR-21-5p is released in the exosomal fraction of cultured DRG following capsaicin activation of TRPV1 receptors. Pure sensory neuron-derived exosomes released by capsaicin are readily phagocytosed by macrophages in which an increase in miR-21-5p expression promotes a pro-inflammatory phenotype...
November 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29171692/8-mercaptoguanine-derivatives-as-inhibitors-of-dihydropteroate-synthase
#8
James Swarbrick, Matthew Dennis, Michael Lee, Jitendra Harjani, Mohamed Ahmed, Aaron Debono, Noel Pitcher, Zhong-Chang Wang, Sandeep Chhabra, Nicholas Barlow, Raphael Rahmani, Ben Cleary, Olan Dolezal, Meghan Hattarki, Luigi Aurelio, Jeremy Shonberg, Bim Graham, Tom Peat, Jonathan Baell
Dihydropteroate synthase (DHPS) is an enzyme of the folate biosynthesis pathway which catalyzes the formation of 7,8-dihydropteroate (DHPt) from 6-hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPPP) and para-aminobenzoic acid (pABA). DHPS is the long-standing target of the sulfonamide class of antibiotics that compete with pABA. In the wake of sulfa drug resistance, targeting the structurally rigid (and more conserved) pterin site has been proposed as an alternate strategy to inhibit DHPS in wild-type and sulfa drug resistant strains...
November 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29166655/how-well-do-you-know-your-mutation-complex-effects-of-genetic-background-on-expressivity-complementation-and-ordering-of-allelic-effects
#9
Christopher H Chandler, Sudarshan Chari, Alycia Kowalski, Lin Choi, David Tack, Michael DeNieu, William Pitchers, Anne Sonnenschein, Leslie Marvin, Kristen Hummel, Christian Marier, Andrew Victory, Cody Porter, Anna Mammel, Julie Holms, Gayatri Sivaratnam, Ian Dworkin
For a given gene, different mutations influence organismal phenotypes to varying degrees. However, the expressivity of these variants not only depends on the DNA lesion associated with the mutation, but also on factors including the genetic background and rearing environment. The degree to which these factors influence related alleles, genes, or pathways similarly, and whether similar developmental mechanisms underlie variation in the expressivity of a single allele across conditions and among alleles is poorly understood...
November 22, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29160842/environmental-exposure-to-dioxins-dibenzofurans-bisphenol-a-and-phthalates-in-children-with-and-without-autism-spectrum-disorder-living-near-the-gulf-of-mexico
#10
Mohammad H Rahbar, Hanes M Swingle, MacKinsey A Christian, Manouchehr Hessabi, MinJae Lee, Meagan R Pitcher, Sean Campbell, Amy Mitchell, Ryan Krone, Katherine A Loveland, Donald G Patterson
Environmental exposure to organic endocrine disrupting chemicals, including dioxins, dibenzofurans, bisphenol A (BPA), and phthalates has been associated with neurodevelopmental disorders, including autism spectrum disorder (ASD). We conducted a pilot monitoring study of 30 ASD cases and 10 typically developing (TD) controls ages 2-8 years from communities along the Gulf of Mexico near Alabama, which houses 14 Superfund sites, to assess the concentrations of dioxins and dibenzofurans in serum, and BPA and phthalate ester metabolites in urine...
November 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29159169/salmonella-enteritis-a-rare-cause-of-adult-intussusception
#11
Toan Pham, Domenic La Paglia, Meron Pitcher
Intussusception is a relatively rare condition in the adult population and is commonly secondary to a malignant process. Eight to twenty percent of cases of adult intussusception are thought to be idiopathic. In children, infection has been proven to precipitate intussusception in the absence of any other cause. We present a rare case of intussusception in a healthy adult patient secondary to salmonella infection and discuss infection as a potential explanation for a proportion of the cases of adult intussusception that are thought to be idiopathic...
October 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/29153478/reliability-of-upper-limb-and-trunk-joint-angles-in-healthy-adults-during-activities-of-daily-living
#12
Susannah M Engdahl, Deanna H Gates
Assessments of upper limb performance should require participants to perform tasks that challenge the limits of their ability. In order to select appropriate tasks, it is important to know which joints are used to perform the movement and how reliably those movements can be measured. The purpose of this work was to quantify the reliability of upper limb and trunk joint angles in healthy adults during common activities of daily living (ADLs). Nineteen participants performed six ADLs with the right arm (applying deodorant, turning a doorknob, answering a desk telephone, placing a pushpin in a bulletin board, wiping a plate with a towel, and pouring water from a pitcher) during two separate sessions...
November 8, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29146167/incidence-and-return-to-play-after-biceps-tenodesis-in-professional-baseball-players
#13
Peter N Chalmers, Brandon J Erickson, Nikhil N Verma, John D'Angelo, Anthony A Romeo
PURPOSE: To determine return to play (RTP) rates after biceps tenodesis (BT) in professional baseball players. METHODS: Major League Baseball has maintained a prospective database containing all major and minor league baseball players who have undergone shoulder surgery since 2010. All players who had undergone BT were included. Minimum follow-up was 24 months, and thus we included data from 2010 to 2013. Using this database we determined the incidence, demographics, prior surgery history, concomitant procedures, RTP rates, and time to RTP...
November 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29140178/infraspinatus-cross-sectional-area-and-shoulder-range-of-motion-change-following-live-game-baseball-pitching
#14
Brett S Pexa, Eric D Ryan, Elizabeth E Hibberd, Elizabeth Teel, Terri Jo Rucinski, Joseph B Myers
CONTEXT: Following a baseball pitching bout, changes can occur to glenohumeral range of motion that could be linked to injury. These effects are in part due to the posterior shoulder's eccentric muscle activity, which can disrupt muscle contractile elements and lead to changes in muscle cross sectional area (CSA), as measured by ultrasound. OBJECTIVE: To assess changes in muscle CSA, and range of motion immediately before and after pitching, and days 1-5 following pitching...
November 15, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29135964/the-killer-of-socrates-coniine-and-related-alkaloids-in-the-plant-kingdom
#15
REVIEW
Hannu Hotti, Heiko Rischer
Coniine, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system, eventually causing death by suffocation in mammals. Coniine's most famous victim is Socrates who was sentenced to death by poison chalice containing poison hemlock in 399 BC. In chemistry, coniine holds two historical records: It is the first alkaloid the chemical structure of which was established (in 1881), and that was chemically synthesized (in 1886)...
November 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29131340/convergent-and-divergent-evolution-in-carnivorous-pitcher-plant-traps
#16
REVIEW
Chris J Thorogood, Ulrike Bauer, Simon J Hiscock
Contents I. II. III. IV. V. VI. References SUMMARY: The pitcher trap is a striking example of convergent evolution across unrelated carnivorous plant lineages. Convergent traits that have evolved across pitcher plant lineages are essential for trap function, suggesting that key selective pressures are in action. Recent studies have also revealed patterns of divergent evolution in functional pitcher morphology within genera. Adaptations to differences in local prey assemblages may drive such divergence and, ultimately, speciation...
November 13, 2017: New Phytologist
https://www.readbyqxmd.com/read/29127102/algorithms-to-guide-ambulance-clinicians-in-the-management-of-emergencies-in-patients-with-implanted-rotary-left-ventricular-assist-devices
#17
REVIEW
Christopher T Bowles, Rachel Hards, Neil Wrightson, Paul Lincoln, Shishir Kore, Laura Marley, Jonathan R Dalzell, Binu Raj, Tracey A Baker, Diane Goodwin, Petra Carroll, Jane Pateman, John J M Black, Paul Kattenhorn, Mark Faulkner, Jayan Parameshwar, Charles Butcher, Mark Mason, Alexander Rosenberg, Ian McGovern, Alexander Weymann, Carl Gwinnutt, Nicholas R Banner, Stephan Schueler, Andre R Simon, David W Pitcher
Advances in left ventricular assist device (LVAD) therapy have resulted in increasing numbers of adult LVAD recipients in the community. However, device failure, stroke, bleeding, LVAD thrombosis and systemic infection can be life-threatening emergencies. Currently, four LVAD systems are implanted in six UK transplant centres, each of which provides device-specific information to local emergency services. This has resulted in inconsistent availability and content of information with the risks of delayed or inappropriate decision-making...
November 10, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29126192/effects-of-exyra-ridingsii-lepidoptera-noctuidae-on-sarracenia-flava-nepenthales-sarraceniaceae
#18
Christine A Ricci, Albert J Meier, Ouida W Meier, T Keith Philips
Exyra ridingsii (Riley) (Lepidoptera: Noctuidae) is a moth whose obligate host is the pitcher plant Sarracenia flava (L.) (Nepenthales: Sarraceniaceae). The entire life cycle of the moth is completed in the trumpets of this fire-dependent plant that is found throughout the southeastern United States in bogs, long-leaf pine savannas, and pocosins. The purpose of this study was to determine the effects of E. ridingsii on S. flava, including the effect of herbivory on trumpet height in the year subsequent to feeding and whether moths select trumpets for oviposition based on height...
November 4, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29099895/radial-shaft-stress-fracture-in-a-major-league-pitcher
#19
Karim A Meijer, Matthew S Fury, Hayley Ennis, Luis Grau, Michael Baraga, Jean Jose, James R Andrews, Lee Kaplan
Upper extremity injuries are associated with significant morbidity in throwing athletes, and prevention and diagnosis of overuse injuries in these athletes are increasingly being emphasized. Although stress fractures are common overuse injuries, stress fractures of the upper extremity are relatively rare. To our knowledge, a stress fracture of the radial shaft has not been reported in a throwing athlete. In this article, we describe the case of a Major League Baseball pitcher who presented with a stress fracture of the lateral cortex of the radius, likely caused by contractile forces of the supinator muscle, arising after his attempt to develop a new pitch...
September 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29093175/the-role-of-visual-cues-in-mother-pup-reunions-in-a-colonially-breeding-mammal
#20
Kaja Wierucka, Benjamin J Pitcher, Robert Harcourt, Isabelle Charrier
Parental care is an important factor influencing offspring survival and adult reproductive success in many vertebrates. Parent-offspring recognition ensures care is only directed to filial young, avoiding the costs of misallocated resource transfer. It is essential in colonial mammal species, such as otariids (fur seals and sea lions), in which repeated mother-offspring separations increase the risk of misdirecting maternal effort. Identification of otariid pups by mothers is known to be multi-modal, yet the role of visual cues in this process remains uncertain...
November 2017: Biology Letters
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