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Charlotte J Frise, Alex Pitcher, Lucy Mackillop
The physiological and haemodynamic changes that occur in pregnancy and the postpartum period increase the risk of aortic dissection. Loeys-Dietz syndrome results from mutations in the genes encoding components of the TGF-β signalling pathway; aortic pathology is of particular concern in this condition but other vascular abnormalities can also be present. Significant maternal morbidity and mortality has been described in patients with Loeys-Dietz syndrome, but successful and uncomplicated pregnancies are still possible...
October 11, 2016: International Journal of Cardiology
Takuya Sekiguchi, Yoshihiro Hagiwara, Haruki Momma, Masahiro Tsuchiya, Kaoru Kuroki, Kenji Kanazawa, Yutaka Yabe, Masashi Koide, Nobuyuki Itaya, Eiji Itoi, Ryoichi Nagatomi
PURPOSE: Serious arm injuries in youth baseball players have been increasing. Though a breakage in the kinetic chain could affect arm injuries, an association between arm injuries and insufficient support of the trunk and lower extremities is not well understood. The purpose of this study was to investigate the association of low back and knee pain with elbow and/or shoulder complaints among youth baseball players. METHODS: A self-administered questionnaire and document informed consent were mailed to youth athletes belonging to the Miyagi Amateur Sports Association...
October 22, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
William R Pitchers, Savvas J Constantinou, Mauricio Losilla, Jason R Gallant
Electric fish have served as a model system in biology since the 18th century, providing deep insight into the nature of bioelectrogenesis, the molecular structure of the synapse, and brain circuitry underlying complex behavior. Neuroethologists have collected extensive phenotypic data that span biological levels of analysis from molecules to ecosystems. This phenotypic data, together with genomic resources obtained over the past decades, have motivated new and exciting hypotheses that position the weakly electric fish model to address fundamental 21(st) century biological questions...
October 18, 2016: Journal of Physiology, Paris
Damien Seth Hunter, Susan J Hazel, Karen L Kind, Hong Liu, Danila Marini, Lynne C Giles, Miles J De Blasio, Julie A Owens, Julia B Pitcher, Kathryn L Gatford
Poor perinatal growth in humans results in asymmetrical grey matter loss in fetuses and infants and increased functional and behavioural asymmetry, but specific contributions of pre- and postnatal growth are unclear. We therefore compared strength and direction of lateralization in obstacle avoidance and maze exit preference tasks in offspring of placentally restricted (PR: 10M, 13F) and control (CON: 23M, 17F) sheep pregnancies at 18 and 40 weeks of age, and examined gross brain structure of the prefrontal cortex at 52 weeks of age (PR: 14M, 18F; CON: 23M, 25F)...
October 19, 2016: Laterality
Gretchen D Oliver, Hillary Plummer, Allison Brambeck
BACKGROUND AND PURPOSE: Range of motion deficits at the hip and glenohumeral joint (GHJ) may contribute to the incidence of injury in softball players. With injury in softball players on the rise, softball related studies in the literature are important. The purpose of this study was to examine hip and GHJ passive range of motion (PROM) patterns in collegiate softball players. HYPOTHESIS: It was hypothesized that the position players would exhibit significantly different PROM patterns than pitchers...
October 2016: International Journal of Sports Physical Therapy
Sakiko Oyama, Andrew G Waldhelm, Araceli R Sosa, Ravina R Patel, Derick L Kalinowski
OBJECTIVE: Pitching technique is one of many factors that affect injury risk. Exhibiting excessive contralateral trunk tilt (CLT) during pitching has been linked to higher ball speed but also to increased joint loading. Deficit in trunk muscle strength has been suggested as an underlying cause of this movement pattern. The purpose of the study was to compare trunk muscle strength between youth baseball pitchers with varying degree of CLT during pitching. DESIGN: Cross-sectional study...
October 6, 2016: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Rebecca B Goody, Helen MacKay, Bethany Pitcher, Amit Oza, Lillian L Siu, John Kim, Rebecca K S Wong, Eric Chen, Carol Swallow, Jennifer Knox, Zahra Kassam, Bernard Cummings, Ron Feld, David Hedley, Geoffrey Liu, Monika K Krzyzanowska, Robert Dinniwell, Anthony M Brade, Laura A Dawson, Melania Pintilie, Jolie Ringash
PURPOSE: Locoregional recurrence is common after surgery for gastric cancer. Adjuvant therapy improves outcomes but with toxicity. This phase 1/2 study investigated infusional 5-fluorouracil (5-FU) in combination with biweekly cisplatin delivered concurrently with image guided high-precision radiation therapy. METHODS AND MATERIALS: Eligible patients had completely resected stage IB to IV (Union for International Cancer Control TNM 6th edition) nonmetastatic gastric adenocarcinoma...
August 31, 2016: International Journal of Radiation Oncology, Biology, Physics
Christine C Johnson, Grant H Garcia, Joseph N Liu, Jeffrey G Stepan, Ronak M Patel, Joshua S Dines
BACKGROUND: The quality of medical information on the Internet has come under scrutiny. This study investigates the quality, accuracy, and readability of online information regarding ulnar collateral ligament (UCL) injuries. METHODS: Three search terms ("elbow ulnar collateral ligament injury," "tommy john injury," and "pitcher's elbow") were entered into 3 Internet search engines. Three independent reviewers evaluated the content and accuracy of the information with a set of predetermined scoring criteria...
October 10, 2016: Journal of Shoulder and Elbow Surgery
Katherine E Reuther, Ryan Larsen, Pamela D Kuhn, John D Kelly, Stephen J Thomas
BACKGROUND: The natural time course for recovery of glenohumeral internal rotation (IR) loss after a throwing episode is unknown. In addition, the effect of the sleeper stretch on the time course for recovery of motion after a throwing episode has never been investigated. Therefore, the objectives of this study were to (1) to determine the natural time course for spontaneous recovery of IR after a throwing episode and (2) to evaluate the effect of the sleeper stretch on the time course for recovery of IR after a throwing episode...
October 10, 2016: Journal of Shoulder and Elbow Surgery
Raffy Mirzayan, Michael J Lim
BACKGROUND: Osteochondritis dissecans (OCD) of the capitellum is a rare yet debilitating injury seen in young athletes. This is the first report in the literature describing fresh osteochondral allograft transplantation (FOCAT) to treat OCD of the capitellum. METHODS: Nine male baseball players (mean age, 15.3; range, 14-18 years), with OCD of the capitellum were treated with FOCAT. There were 6 pitchers and 3 position players. A ligament-sparing, mini-open approach was used...
November 2016: Journal of Shoulder and Elbow Surgery
Jorge Delgado, Diego Jaramillo, Nancy A Chauvin
Increased physical activity in childhood has resulted in a large number of sports-related injuries. Although there is overlap between the sports-related injuries seen in pediatric and adult patients, important differences exist in the injury patterns of pediatric patients. These differences are related to the continuous changes in the developing skeleton and its relationship with adjacent soft tissues. The imbalance in strength between the growing bones and the nearby tendons and ligaments makes the bones prone to acute and chronic injuries...
October 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Scott W Cheatham, Kathryn Kumagai Shimamura, Morey J Kolber
The purpose of this study was to measure passive hip internal (IR) and external rotation (ER) range of motion (ROM) in collegiate baseball pitchers and compare to published youth and professional values. Measures were taken on the bilateral hips of 29 participants (mean age 20.0±1.4, range 18-22 years). Results identified no significant differences between the stance and stride hip in collegiate right handed pitchers for IR (p= 0.22, ES 0.23) and ER (p=.08, ES= 0.25). There was no significant difference in left handed pitchers for IR (p= 0...
September 2016: Journal of the Canadian Chiropractic Association
Sakiko Oyama, Araceli Sosa, Rebekah Campbell, Alexandra Correa
Video recordings are used to quantitatively analyze pitchers' technique. However, reliability and validity of such analysis is unknown. The purpose of the study was to investigate the reliability and validity of joint and segment angles identified during a pitching motion using video analysis. Thirty high school baseball pitchers participated. The pitching motion was captured using two high-speed video cameras and a motion capture system. Two raters reviewed the videos to digitize the body segments to calculate two-dimensional angles...
October 5, 2016: Journal of Applied Biomechanics
Arkady Khoutorsky, Robert E Sorge, Masha Prager-Khoutorsky, Sophie Anne Pawlowski, Geraldine Longo, Seyed Mehdi Jafarnejad, Soroush Tahmasebi, Loren J Martin, Mark H Pitcher, Christos G Gkogkas, Reza Sharif-Naeini, Alfredo Ribeiro-da-Silva, Charles W Bourque, Fernando Cervero, Jeffrey S Mogil, Nahum Sonenberg
A response to environmental stress is critical to alleviate cellular injury and maintain cellular homeostasis. Eukaryotic initiation factor 2 (eIF2) is a key integrator of cellular stress responses and an important regulator of mRNA translation. Diverse stress signals lead to the phosphorylation of the α subunit of eIF2 (Ser51), resulting in inhibition of global protein synthesis while promoting expression of proteins that mediate cell adaptation to stress. Here we report that eIF2α is instrumental in the control of noxious heat sensation...
October 3, 2016: Proceedings of the National Academy of Sciences of the United States of America
Chaitra S Ujjani, Sin-Ho Jung, Brandelyn Pitcher, Peter Martin, Steven I Park, Kristie A Blum, Sonali M Smith, Myron Czuczman, Matthew S Davids, Ellis Levine, Lionel D Lewis, Scott E Smith, Nancy L Bartlett, John P Leonard, Bruce D Cheson
Chemoimmunotherapy in follicular lymphoma is associated with significant toxicity. Targeted therapies are being investigated as potentially more efficacious and tolerable alternatives for this multiply-relapsing disease. Based on promising activity with rituximab and lenalidomide in previously untreated follicular lymphoma (ORR 90-96%) and ibrutinib in relapsed disease (ORR 30-55%), the Alliance for Clinical Trials in Oncology conducted a phase I trial of rituximab, lenalidomide, and ibrutinib. Previously untreated patients with follicular lymphoma received rituximab 375 mg/m(2) on Day 1, 8, 15, 22 of Cycle 1 and Day 1 of Cycle 4, 6, 8, 10, lenalidomide as per cohort dose on Days 1-21/28 for 18 cycles, and ibrutinib as per cohort dose daily until progression...
October 3, 2016: Blood
Garrett M Pitcher, Kenneth R Hogstrom, Robert L Carver
This study provided baseline data required for a greater project, whose objective was to design a new Elekta electron collimation system having significantly lighter electron applicators with equally low out-of field leakage dose. Specifically, off-axis dose profiles for the electron collimation system of our uniquely configured Elekta Infinity accelerator with the MLCi2 treatment head were measured and calculated for two primary purposes: 1) to evaluate and document the out-of-field leakage dose in the patient plane and 2) to validate the dose distributions calculated using a BEAMnrc Monte Carlo (MC) model for out-of-field dose profiles...
2016: Journal of Applied Clinical Medical Physics
Ming-Sound Tsao, Licun Wu, Ghassan Allo, Thomas John, Ming Li, Tetsuzo Tagawa, Isabelle Opitz, Masaki Anraku, Zhihong Yun, Melania Pintilie, Geoffrey Liu, Bethany Pitcher, Ron Feld, Michael R Johnston, Marc de Perrot
PURPOSE: Malignant pleural mesothelioma (MPM) is a rare but aggressive disease with few therapeutic options. The tumor stromal interface is important in MPM, but this is lost in cell lines, the main model used for preclinical studies. We sought to characterise MPM patient derived xenografts (PDX) to determine their suitability as pre-clinical models and whether tumors that engraft reflect a more aggressive biological phenotype. EXPERIMENTAL DESIGN: Fresh tumors were harvested from extrapleural pneumonectomy (EPP), decortication or biopsy samples of 50 MPM patients, and implanted subcutaneously into immunodeficient mice and serially passaged for up to five generations...
September 28, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
G Lee, R Dinniwell, T W Fyles, T D Conrad, K Han, W Levin, F F Liu, S Lofgren, A Koch-Fitsialos, G Devins, N Emad, B Pitcher, T Panzarella, A Koch
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Amy M West, Donna M Scarborough, Kelly C McInnis, Luke S Oh
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Paulo M G Sales, Loraine M S de Andrade, Meagan R Pitcher, Francisco H Rola, Francisco de A A Gondim
BACKGROUND: The repetitive ElectroMagnetic Stimulation (rEMS) is an innocuous method applied to modulate neurocircuits in real-time to study the physiology of the central nervous system and treat neuropsychiatric conditions. Preliminary data suggest that spinal rEMS induces behavioral changes in awake rats. However, the mechanisms behind this phenomenon remain largely unknown. METHODS: Twenty-five male Wistar rats were divided into five subgroups of five animals each: one subgroup was drug-free, two subgroups received Levodopa+Benserazide 250+25mg/kg for two or seven days, and the remaining two subgroups received Haloperidol 0...
October 28, 2016: Neuroscience Letters
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