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https://www.readbyqxmd.com/read/28426624/a-randomized-double-blind-placebo-control-pilot-study-of-eplerenone-for-the-treatment-of-central-serous-chorioretinopathy-ecselsior
#1
Ehsan Rahimy, John D Pitcher, Jason Hsu, Murtaza K Adam, Abtin Shahlaee, Wasim A Samara, James F Vander, Richard S Kaiser, Allen Chiang, Marc J Spirn, Mitchell S Fineman
PURPOSE: To evaluate the safety and effects of oral eplerenone in chronic central serous chorioretinopathy. METHODS: Prospective, randomized, double-blind, placebo-control study at a tertiary referral academic private practice. For a diagnosis of chronic central serous chorioretinopathy, patients must have had at least 3 months clinical follow-up demonstrating persistent symptoms, subfoveal fluid on spectral-domain optical coherence tomography, and <50% reduction in fluid thickness...
April 19, 2017: Retina
https://www.readbyqxmd.com/read/28401597/unidirectional-wetting-properties-on-multi-bioinspired-magnetocontrollable-slippery-microcilia
#2
Moyuan Cao, Xu Jin, Yun Peng, Cunming Yu, Kan Li, Kesong Liu, Lei Jiang
Here, a smart fluid-controlled surface is designed, via the rational integration of the unique properties of three natural examples, i.e., the unidirectional wetting behaviors of butterfly's wing, liquid-infused "slippery" surface of the pitcher plant, and the motile microcilia of micro-organisms. Anisotropic wettability, lubricated surfaces, and magnetoresponsive microstructures are assembled into one unified system. The as-prepared surface covered by tilted microcilia achieves significant unidirectional droplet adhesion and sliding...
April 12, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28398820/magnetic-resonance-imaging-predictors-of-failure-in-the-nonoperative-management-of-ulnar-collateral-ligament-injuries-in-professional-baseball-pitchers
#3
Salvatore J Frangiamore, T Sean Lynch, Michael D Vaughn, Lonnie Soloff, Michael Forney, Joseph F Styron, Mark S Schickendantz
BACKGROUND: A medial ulnar collateral ligament (UCL) injury of the elbow is an increasingly common injury in professional baseball pitchers. Predictors of success and failure are not well defined for the nonoperative management of these injuries. PURPOSE: To evaluate the efficacy of objective measures to predict failure of the nonoperative management of UCL injuries. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: Thirty-two professional pitchers (82%) met inclusion criteria and underwent an initial trial of nonoperative treatment for UCL tears based on clinical and radiological findings...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28394713/elbow-mri-findings-do-not-correlate-with-future-placement-on-the-disabled-list-in-asymptomatic-professional-baseball-pitchers
#4
Nicholas M Gutierrez, Christopher Granville, Lee Kaplan, Michael Baraga, Jean Jose
BACKGROUND: Injury rates among professional baseball players may reach as high as 5.8 per 1000 encounters, with pitchers being most vulnerable on account of the excessive biomechanical load on the upper extremity during the throwing motion. Anatomically, the shoulder is the most common site of pitching-related injury, accounting for 30.7% of injuries, closely followed by the elbow at 26.3%. Characteristic valgus loading imparts a predictable constellation of stresses on the joint, including medial tension, lateral compression, and posterior medial shearing...
April 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28390087/do-ecological-communities-disperse-across-biogeographic-barriers-as-a-unit
#5
Jordan D Satler, Bryan C Carstens
Biogeographic barriers have long been implicated as drivers of biological diversification, but how these barriers influence co-occurring taxa can vary depending on factors intrinsic to the organism and in their relationships with other species. Due to the interdependence among taxa, ecological communities present a compelling opportunity to explore how interactions among species may lead to a shared response to historical events. Here we collect single nucleotide polymorphism (SNP) data from five commensal arthropods associated with the Sarracenia alata carnivorous pitcher plant, and test for co-diversification across the Mississippi River, a major biogeographic barrier in the southeastern United States...
April 8, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28387789/evolution-of-wood-anatomical-characters-in-nepenthes-and-close-relatives-of-caryophyllales
#6
Rachel Schwallier, Barbara Gravendeel, Hugo de Boer, Stephan Nylinder, Bertie Joan van Heuven, Anton Sieder, Sukaibin Sumail, Rogier van Vugt, Frederic Lens
Background and Aims: Nepenthes attracts wide attention with its spectacularly shaped carnivorous pitchers, cultural value and horticultural curiosity. Despite the plant's iconic fascination, surprisingly little anatomical detail is known about the genus beyond its modified leaf tip traps. Here, the wood anatomical diversity of Nepenthes is explored. This diversity is further assessed with a phylogenetic framework to investigate whether the wood characters within the genus are relevant from an evolutionary or ecological perspective, or rather depend on differences in developmental stages, growth habits, substrates or precipitation...
April 6, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28387056/effects-of-ovarian-fluid-and-genetic-differences-on-sperm-performance-and-fertilization-success-of-alternative-reproductive-tactics-in-chinook-salmon
#7
Sarah J Lehnert, Ian A E ButtS, Erin W Flannery, Kia M Peters, Daniel D Heath, Trevor E Pitcher
In many species, sperm velocity affects variation in the outcome of male competitive fertilization success. In fishes, ovarian fluid (OF) released with the eggs can increase male sperm velocity and potentially facilitate cryptic female choice for males of specific phenotypes and/or genotypes. Therefore, to investigate the role of OF on fertilization success, we measured sperm velocity and conducted in vitro competitive fertilizations with paired Chinook salmon (Oncorhynchus tshawytscha) males representing two alternative reproductive tactics, jacks (small sneaker males) and hooknoses (large guarding males), in the presence of river water alone and OF mixed with river water...
April 7, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28386412/cross-modal-recognition-of-familiar-conspecifics-in-goats
#8
Benjamin J Pitcher, Elodie F Briefer, Luigi Baciadonna, Alan G McElligott
When identifying other individuals, animals may match current cues with stored information about that individual from the same sensory modality. Animals may also be able to combine current information with previously acquired information from other sensory modalities, indicating that they possess complex cognitive templates of individuals that are independent of modality. We investigated whether goats (Capra hircus) possess cross-modal representations (auditory-visual) of conspecifics. We presented subjects with recorded conspecific calls broadcast equidistant between two individuals, one of which was the caller...
February 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28377137/hazards-and-incidents-detection-and-learning-in-radiation-medicine-a-comparison-of-2-educational-interventions
#9
Robert Thompson, Yilan Lu, Marc Potvin, Jordan Holmes, Lisa Di Prospero, Brian Keller, Ewa Szumacher, Brian Liszewski, Pamela Catton, Meredith Giuliani, Bethany Pitcher, Melania Pintilie, Jean-Pierre Bissonnette
PURPOSE: Interprofessional, educational live simulations were compared with group discussion-based exercises in terms of their ability to improve radiation medicine trainees' ability to detect hazards and incidents and understand behaviors that may prevent them. METHODS AND MATERIALS: Trainees and recent graduates of radiation therapy, medical physics, and radiation oncology programs were recruited and randomized to either a simulation-based or group discussion-based training intervention...
February 27, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28367985/oil-adsorption-ability-of-three-dimensional-epicuticular-wax-coverages-in-plants
#10
Elena V Gorb, Philipp Hofmann, Alexander E Filippov, Stanislav N Gorb
Primary aerial surfaces of terrestrial plants are very often covered with three-dimensional epicuticular waxes. Such wax coverages play an important role in insect-plant interactions. Wax blooms have been experimentally shown in numerous previous studies to be impeding locomotion and reducing attachment of insects. Among the mechanisms responsible for these effects, a possible adsorption of insect adhesive fluid by highly porous wax coverage has been proposed (adsorption hypothesis). Recently, a great decrease in insect attachment force on artificial adsorbing materials was revealed in a few studies...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28364214/frailty-and-long-term-mortality-of-older-breast-cancer-patients-calgb-369901-alliance
#11
Jeanne S Mandelblatt, Ling Cai, George Luta, Gretchen Kimmick, Jonathan Clapp, Claudine Isaacs, Brandeyln Pitcher, William Barry, Eric Winer, Stephen Sugarman, Clifford Hudis, Hyman Muss, Harvey J Cohen, Arti Hurria
PURPOSE: Breast cancer patients aged 65+ ("older") vary in frailty status. We tested whether a deficits accumulation frailty index predicted long-term mortality. METHODS: Older patients (n = 1280) with non-metastatic, invasive breast cancer were recruited from 78 Alliance sites from 2004 to 2011, with follow-up to 2015. Frailty categories (robust, pre-frail, and frail) were based on 35 baseline illness and function items. Cox proportional hazards and competing risk models were used to calculate all-cause and breast cancer-specific mortality for up to 7 years, respectively...
March 31, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28361439/cost-effectiveness-analysis-of-regorafenib-for-gastrointestinal-stromal-tumour-gist-in-germany
#12
David Tamoschus, Katja Draexler, Jane Chang, Christopher Ngai, Matthew Madin-Warburton, Ashley Pitcher
BACKGROUND: No study has compared the cost-effectiveness of active treatment options for unresectable or metastatic gastrointestinal stromal tumours in patients who progressed on or are intolerant to prior treatment with imatinib and sunitinib. The aim of this study was to estimate the cost-effectiveness of regorafenib compared to imatinib rechallenge in this setting in Germany. METHODS: Hazard ratios for progression-free (PFS) and overall survival (OS) with regorafenib versus imatinib rechallenge were estimated by indirect comparison...
March 30, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28345616/shoulder-stretching-intervention-reduces-the-incidence-of-shoulder-and-elbow-injuries-in-high-school-baseball-players-a-time-to-event-analysis
#13
Hitoshi Shitara, Atsushi Yamamoto, Daisuke Shimoyama, Tsuyoshi Ichinose, Tsuyoshi Sasaki, Noritaka Hamano, Akira Ueno, Fumitaka Endo, Atsufumi Oshima, Hideo Sakane, Masahiro Tachibana, Yusuke Tomomatsu, Tsuyoshi Tajika, Tsutomu Kobayashi, Toshihisa Osawa, Haku Iizuka, Kenji Takagishi
We prospectively evaluated the effects of a prevention program on the incidence of shoulder and elbow injuries in high school baseball pitchers. Ninety-two pitchers participated in this study and were taught to perform stretching and strength exercises aimed at improving shoulder external rotation strength in the preseason. The pitchers freely chose to participate in one of four groups [SM-group: performed both exercises, S-group: performed stretching exercise only, M-group: performed strength training only, and N-group: performed neither intervention]...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28328567/effects-of-a-simulated-game-on-upper-extremity-pitching-mechanics-and-muscle-activations-among-various-pitch-types-in-youth-baseball-pitchers
#14
Gretchen D Oliver, Hillary Plummer, Lisa Henning, Michael Saper, Gabrielle Glimer, Allison Brambeck, James R Andrews
BACKGROUND: Throwing requires proper stability and orientation of the pelvis and scapula for efficient energy transfer during pitching. Fatigue of the pelvis and scapular musculature throughout the course of a game can impair pitching performance, and place excessive demands on the throwing arm leading to injury. The purpose of this study was to examine differences in pelvis, torso, and upper extremity pitching mechanics and muscle activations between the fastball, change-up, and curveball pitches in youth baseball pitchers following a simulated game...
March 21, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28325273/length-of-time-between-surgery-and-return-to-sport-after-ulnar-collateral-ligament-reconstruction-in-major-league-baseball-pitchers-does-not-predict-need-for-revision-surgery
#15
Brandon J Erickson, Peter N Chalmers, Bernard R Bach, Joshua S Dines, Nikhil N Verma, Charles A Bush-Joseph, Steven B Cohen, Anthony A Romeo
HYPOTHESIS: Pitchers who return to sport (RTS) sooner will have a higher risk of revision ulnar collateral ligament reconstruction (UCLR) than those who return later. METHODS: All professional (major and minor league) baseball pitchers who underwent UCLR between 1974 and 2016 were identified. Date of the index UCLR was recorded. The date of the first game back at any professional level after surgery and the date the pitcher returned to the same level of play (if applicable) were recorded...
April 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28321427/the-effect-of-the-number-of-carries-on-injury-risk-and-subsequent-season-s-performance-among-running-backs-in-the-national-football-league
#16
Matthew J Kraeutler, John W Belk, Eric C McCarty
BACKGROUND: In recent years, several studies have correlated pitch count with an increased risk for injury among baseball pitchers. However, no studies have attempted to draw a similar conclusion based on number of carries by running backs (RBs) in football. PURPOSE: To determine whether there is a correlation between number of carries by RBs in the National Football League (NFL) and risk of injury or worsened performance in the subsequent season. STUDY DESIGN: Cohort study; Level of evidence, 3...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28314699/safety-and-tolerability-of-idelalisib-lenalidomide-and-rituximab-in-relapsed-and-refractory-lymphoma-the-alliance-for-clinical-trials-in-oncology-a051201-and-a051202-phase-1-trials
#17
Sonali M Smith, Brandelyn N Pitcher, Sin-Ho Jung, Nancy L Bartlett, Nina Wagner-Johnston, Steven I Park, Kristy L Richards, Amanda F Cashen, Anthony Jaslowski, Scott E Smith, Bruce D Cheson, Eric Hsi, John P Leonard
BACKGROUND: A new generation of biological and targeted agents might potentially replace traditional cytotoxic agents in lymphoma. Lenalidomide plus rituximab was felt to be a safe and promising backbone based on available data. Idelalisib is an oral phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor that has promising activity as a monotherapy in refractory indolent lymphomas. The primary objective of these two trials was to determine the maximum tolerated dose of lenalidomide in combination with rituximab and idelalisib in relapsed follicular and mantle cell lymphoma...
April 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28303472/chronic-exertional-compartment-syndrome-in-the-forearm-of-a-collegiate-softball-pitcher
#18
REVIEW
Austin Cole, John L Hiatt, Christopher Arnold, Terry Sites, Ramon Ylanon
BACKGROUND: Chronic exertional compartment syndrome (CECS) is a recognized condition in the lower limb, with many reports in the literature. However, very few instances include CECS of the upper limb. This article presents the case of a collegiate softball pitcher presenting with CECS in her right forearm. To our knowledge, this is the first case report of a softball player with CECS, with only one similar incident in a major league baseball player. PURPOSE: The rarity of this condition normally places it low on the differential diagnosis...
December 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28298058/effect-of-pitching-consecutive-days-in-youth-fast-pitch-softball-tournaments-on-objective-shoulder-strength-and-subjective-shoulder-symptoms
#19
S Andrew Skillington, Robert H Brophy, Rick W Wright, Matthew V Smith
BACKGROUND: The windmill pitching motion has been associated with risk for shoulder injury. Because there are no pitching limits on youth fast-pitch softball pitchers, these athletes often pitch multiple games across consecutive days. Strength changes, fatigue levels, and shoulder pain that develop among female fast-pitch pitchers over the course of consecutive days of pitching have not been investigated. HYPOTHESIS: Over the course of 2- and 3-day fast-pitch softball tournaments, pitchers will develop progressive objective weakness and increased subjective shoulder fatigue and pain without complete recovery between days...
February 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28297419/radiation-leakage-dose-from-elekta-electron-collimation-system
#20
Garrett M Pitcher, Kenneth R Hogstrom, Robert L Carver
This study provided baseline data required for a greater project, whose objective was to design a new Elekta electron collimation system having significantly lighter electron applicators with equally low out-of field leakage dose. Specifically, off-axis dose profiles for the electron collimation system of our uniquely configured Elekta Infinity accelerator with the MLCi2 treatment head were measured and calculated for two primary purposes: 1) to evaluate and document the out-of-field leakage dose in the patient plane and 2) to validate the dose distributions calculated using a BEAMnrc Monte Carlo (MC) model for out-of-field dose profiles...
September 2016: Journal of Applied Clinical Medical Physics
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