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Chrishan Thakar, David Christopher Kieser, Mihai Mardare, Shahnawaz Haleem, Jeremy Fairbank, Colin Nnadi
PURPOSE: To analyse the complication profile of magnetically controlled growing rods (MCGRs) in early onset scoliosis (EOS). METHODS: This is a systematic review using PUBMED, Medline, Embase, Google Scholar and the Cochrane Library (keywords: MAGEC, Magnetically controlled growing rods and EOS) of all studies written in English with a minimum of five patients and a 1-year follow-up. We evaluated coronal correction, growth progression (T1-S1, T1-T12) and complications...
April 19, 2018: European Spine Journal
Christof Birkenmaier, Melvin D'Anastasi, Bernd Wegener, Carolin Melcher
BACKGROUND: We describe a case of severe and progressive lumbar hyperlordosis (160°) in a 28-year-old female university student with cerebral palsy. Her main complaints were abdominal wall pain and increasing inability to sit in her custom wheelchair. METHOD: When deciding on our opinion about the most promising treatment strategy, we contemplated slow continued correction by means of percutaneously expandable magnetic rods (MAGEC) after the index surgery as a key component of a satisfactory correction in this severe and rigid curve...
November 22, 2017: European Spine Journal
P R P Rushton, I Siddique, R Crawford, N Birch, M J Gibson, M J Hutton
The MAGnetic Expansion Control (MAGEC) system is used increasingly in the management of early-onset scoliosis. Good results have been published, but there have been recent reports identifying implant failures that may be associated with significant metallosis surrounding the implants. This article aims to present the current knowledge regarding the performance of this implant, and the potential implications and strategies that may be employed to identify and limit any problems. We urge surgeons to apply caution to patient and construct selection; engage in prospective patient registration using a spine registry; ensure close clinical monitoring until growth has ceased; and send all explanted MAGEC rods for independent analysis...
June 2017: Bone & Joint Journal
Thomas J Joyce, Simon L Smith, Paul R P Rushton, Andrew J Bowey, Michael J Gibson
STUDY DESIGN: Analysis of explanted MAGnetic Expansion Control (MAGEC) growing rods. OBJECTIVE: To analyze explanted MAGEC rods used in management of early onset scoliosis and identify the mode of failure in such cases. SUMMARY OF BACKGROUND DATA: Magnetically controlled growing rods are increasingly used as the option of choice for early onset scoliosis. However, being more complex than conventional growing rods they are perhaps more likely to succumb to multifarious failure modes...
January 1, 2018: Spine
Umesh Metkar, Swamy Kurra, David Quinzi, Stephen Albanese, William F Lavelle
Early onset scoliosis can be both a disfiguring as well as a life threatening condition. When more conservative treatments fail, pediatric spinal surgeons are forced to consider operative interventions. Traditionally, these interventions have involved the insertion of a variety of implants into the patient with a limited number of anchor points controlling the spine. In the past, these pediatric patients have had multiple surgeries for elective lengthening of these devices to facilitate their growth while attempting to control the scoliosis...
February 2017: Expert Review of Medical Devices
W Thompson, C Thakar, D J Rolton, J Wilson-MacDonald, C Nnadi
AIMS: We undertook a prospective non-randomised radiological study to evaluate the preliminary results of using magnetically-controlled growing rods (MAGEC System, Ellipse technology) to treat children with early-onset scoliosis. PATIENTS AND METHODS: Between January 2011 and January 2015, 19 children were treated with magnetically-controlled growing rods (MCGRs) and underwent distraction at three-monthly intervals. The mean age of our cohort was 9.1 years (4 to 14) and the mean follow-up 22...
September 2016: Bone & Joint Journal
Conor S Jones, Oliver M Stokes, Salil B Patel, Andrew J Clarke, Michael Hutton
BACKGROUND CONTEXT: Magnetically controlled growing rods (MCGRs) are used in the management of early-onset scoliosis (EOS). Each MCGR contains a telescopic actuator that serves as the distraction element when stimulated by an external remote controller (ERC), permitting non-invasive lengthening in the outpatient clinic. PURPOSE: This report highlights a subtle cause of MCGR failure. We present the first two reported cases of lengthening pin fracture in patients with dual-MCGR constructs...
April 2016: Spine Journal: Official Journal of the North American Spine Society
Guido La Rosa, Leonardo Oggiano, Laura Ruzzini
BACKGROUND: A new method for the management of early-onset scoliosis (EOS) has been recently introduced: it consists of a magnetically controlled growing rod (MCGR) that allows gradual outpatient distractions under control of an external remote device. The aim of the present study is to present a series of 10 patients with EOS managed with MCGR (Ellipse TM MAGEC System, Irvine, CA). METHODS: We implanted MCGR in 10 patients affected by EOS. Scoliosis and kyphosis angles, T1-T12 and T1-S1 length were evaluated preoperatively, postoperatively, and at the last follow-up...
March 2017: Journal of Pediatric Orthopedics
Michelle Jenks, Joyce Craig, Joanne Higgins, Iain Willits, Teresa Barata, Hannah Wood, Christine Kimpton, Andrew Sims
Scoliosis-structural lateral curvature of the spine-affects around four children per 1,000. The MAGEC system comprises a magnetically distractible spinal rod implant and an external remote controller, which lengthens the rod; this system avoids repeated surgical lengthening. Rod implants brace the spine internally and are lengthened as the child grows, preventing worsening of scoliosis and delaying the need for spinal fusion. The Medical Technologies Advisory Committee at the National Institute for Health and Care Excellence (NICE) selected the MAGEC system for evaluation in a NICE medical technologies guidance...
December 2014: Applied Health Economics and Health Policy
Tasuku Terada, Sarah Loehr, Emmanuel Guigard, Linda J McCargar, Gordon J Bell, Peter Senior, Normand G Boulé
AIMS: This study determined the test-retest reliability of a continuous glucose monitoring system (CGMS) (iPro™2; Medtronic, Northridge, CA) under standardized conditions in individuals with type 2 diabetes (T2D). SUBJECTS AND METHODS: Fourteen individuals with T2D spent two nonconsecutive days in a calorimetry unit. On both days, meals, medication, and exercise were standardized. Glucose concentrations were measured continuously by CGMS, from which daily mean glucose concentration (GLU(mean)), time spent in hyperglycemia (t(>10...
August 2014: Diabetes Technology & Therapeutics
B A Hickey, C Towriss, G Baxter, S Yasso, S James, A Jones, J Howes, P Davies, S Ahuja
PURPOSE: Magnetically controlled growing rod systems have been introduced over recent years as an alternative to traditional growing rods for management of early onset scoliosis. The purpose of this paper is to report our early experience of a magnetically controlled growing rod system (MAGEC, Ellipse). METHODS: Review of pre-operative, postoperative and follow-up Cobb angles and spinal growth in case series of eight patients with a minimum 23 months' follow-up (23-36 months)...
April 2014: European Spine Journal
Leila Khoja, Patrick Shenjere, Clare Hodgson, Jackie Hodgetts, Glen Clack, Andrew Hughes, Paul Lorigan, Caroline Dive
We previously demonstrated that circulating tumour cells (CTCs) are detectable by the MelCAM and high molecular weight melanoma-associated antigen (HMW-MAA)-dependent CellSearch platform. However, CTCs which do not express these capture and detection markers are not detectable by CellSearch. Consequently, we explored the use of isolation by size of epithelial tumour cells (ISET), a marker independent, filtration-based device to determine the prevalence and heterogeneity of CTCs in metastatic cutaneous melanoma patients...
February 2014: Melanoma Research
Suk Chon, Yun Jung Lee, Gemma Fraterrigo, Paolo Pozzilli, Moon Chan Choi, Mi-Kwang Kwon, Sang Ouk Chin, Sang Youl Rhee, Seungjoon Oh, Young-Seol Kim, Jeong-Taek Woo
AIMS: It is necessary to evaluate glucose variability and postprandial hyperglycemia in patients with well-controlled type 2 diabetes mellitus because of the limitations associated with hemoglobin A1c (HbA1c) measurements. We evaluated parameters reflecting postprandial hyperglycemia and glycemic variability in patients with optimal HbA1c. PATIENTS AND METHODS: Thirty-nine patients with HbA1c levels below 7% were recruited to the study. A continuous glucose monitoring system (CGMS) was applied for two 72-h periods...
June 2013: Diabetes Technology & Therapeutics
Christine Bodemer
For more than 20 years, the department of dermatology in the Necker Enfants Malades Hospital (Paris) has been organizing the coordination of an epidermolysis bullosa-specific multidisciplinary management. The French Ministry of Health distinguished this hospital as a reference center for rare diseases. MAGEC-Necker now aims to offer the best medical and social management of epidermolysis bullosa.
April 2010: Dermatologic Clinics
P M May, D R Williams, P W Linder, R G Torrington
The computer program, MAGEC (Multiple Analysis of titration data for Glass Electrode Calibration), described can optimize simultaneously any or all of the titration parameters pertinent to the calibration of glass electrodes. In particular, the protonation constants of a ligand and the glass-electrode parameters may be determined simultaneously from a given single set of titration data. A method is described for obtaining definitive values of these parameters, involving cyclical treatment of titration data by means of MAGEC and another program such as MINIQUAD...
April 1982: Talanta
Zane Kalniņa, Karīna Siliņa, Irēna Meistere, Pawel Zayakin, Alexander Rivosh, Artūrs Abols, Mārcis Leja, Olga Minenkova, Dirk Schadendorf, Aija Linē
In the current study we attempted to evaluate the suitability of T7 Select 10-3b and lambdaKM8 phage display systems for the identification of antigens eliciting B cell responses in cancer patients and the production of phage-displayed antigen microarrays that could be exploited for the monitoring of autoantibody profiles. Members of 15 tumour-associated antigen (TAA) families were cloned into both phage display vectors and the TAA mini-libraries were immunoscreened with 22 melanoma patients' sera resulting in the detection of reactivity against members of 5 antigen families in both systems, yet with variable sensitivity...
May 20, 2008: Journal of Immunological Methods
P M Consigny, D A Silverberg, N J Vitali
PURPOSE: The purpose of this study was to determine if the luminal surface of balloon-dilated arteries can be re-endothelialized circumferentially with use of normal endothelial cells (ECs) and superparamagnetic microsphere-containing endothelial cells (MagECs) to cover gravity-dependent and independent arterial surfaces, respectively. MATERIALS AND METHODS: MagECs were obtained after phagocytosis of albumin-coated superparamagnetic polystyrene microspheres by rabbit microvascular ECs...
February 1999: Journal of Vascular and Interventional Radiology: JVIR
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