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https://www.readbyqxmd.com/read/29471053/morphological-and-functional-evidence-of-increased-excitatory-signaling-in-the-prelimbic-cortex-during-ethanol-withdrawal
#1
Florence P Varodayan, Harpreet Sidhu, Max Kreifeldt, Marisa Roberto, Candice Contet
Excessive alcohol consumption in humans induces deficits in decision making and emotional processing, which indicates a dysfunction of the prefrontal cortex (PFC). The present study aimed to determine the impact of chronic intermittent ethanol (CIE) inhalation on mouse medial PFC pyramidal neurons. Data were collected 6-8 days into withdrawal from 7 weeks of CIE exposure, a time point when mice exhibit behavioral symptoms of withdrawal. We found that spine maturity in prelimbic (PL) layer 2/3 neurons was increased, while dendritic spines in PL layer 5 neurons or infralimbic (IL) neurons were not affected...
February 19, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29465475/physical-activity-and-bone-accretion-isotemporal-modeling-and-genetic-interactions
#2
Jonathan A Mitchell, Alessandra Chesi, Shana E McCormack, Diana L Cousminer, Heidi J Kalkwarf, Joan M Lappe, Vicente Gilsanz, Sharon E Oberfield, John A Shepherd, Andrea Kelly, Struan F A Grant, Babette S Zemel
PURPOSE: To determine if replacing time spent in high and low impact physical activity (PA) predicts changes in pediatric bone mineral density (BMD) and content (BMC). METHODS: We analyzed data from the longitudinal Bone Mineral Density in Childhood Study (N=2,337 with up to 7 visits). The participants were aged 5-19 years at baseline, 51.2% were female and 80.6% were non-Black. Spine, total hip, and femoral neck areal BMD (aBMD) and total body less head (TBLH) BMC Z-scores were calculated...
February 20, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29464369/bibliometric-study-of-the-orthopaedic-publications-from-china
#3
REVIEW
Jing Sun, Yan Guo, Marius M Scarlat, Guang Lv, Xiong-Gang Yang, Yong-Cheng Hu
PURPOSE: We aimed to investigate the status quo of orthopaedic publications from China and characterize the most-cited articles to provide valuable insights for orthopaedists. METHODS: PubMed and Embase databases were used to search for Chinese orthopaedic publications from 1997 to 2017 to determine the growing pattern of Chinese research globally. Then Web of Science database was searched for articles with most citations in all journals included in the Journal Citation Report 2016 under the category of "orthopaedics" for the last five years, and the total numbers of articles in the last three respective years were also analyzed...
February 20, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29410774/peritraumatic-distress-fully-mediates-the-relationship-between-posttraumatic-stress-symptoms-preoperative-and-three-months-postoperative-in-patients-undergoing-spine-surgery
#4
Ehab Shiban, Jens Lehmberg, Ute Hoffmann, Jeff Thiel, Thomas Probst, Margret Friedl, Andreas Mühlberger, Bernhard Meyer, Youssef Shiban
Background: Growing evidence shows the significance of illness and surgical procedures as traumatizing stressors. Risk factors are widely investigated in various settings and samples, using numerous measures of posttraumatic stress and posttraumatic stress disorder (PTSD). While pretrauma psychological distress is acknowledged as an influential factor, peritraumatic experiences are controversially still being discussed as relevant to the development of PTSD. Objective: In a group of patients consecutively undergoing elective spine surgery (N = 89) in a German hospital, this longitudinal study addressed the question of how pretrauma PTSD symptoms and peritrauma distress interact with one another in regard to the amount of posttrauma symptoms of PTSD...
2018: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29405381/intracerebroventricular-administration-of-growth-hormone-induces-morphological-changes-in-pyramidal-neurons-of-the-hippocampus-and-prefrontal-cortex-in-adult-rats
#5
Juan David Olivares Hernández, Fabio García-García, Israel Camacho-Abrego, Gonzalo Flores, Enrique Juárez-Aguilar
A growing body of evidence suggests that growth hormone (GH) affects synaptic plasticity at both the molecular and electrophysiological levels. However, unclear is whether plasticity that is stimulated by GH is associated with changes in neuron structure. The present study investigated the effect of intracerebroventricular (ICV) administration of GH on the morphology of pyramidal neurons of the CA1 region of the dorsal hippocampus and layer III of the prefrontal cortex. Male Wistar rats received daily ICV injections of GH (120 ng) for 7 days, and they were euthanized 21 days later...
February 5, 2018: Synapse
https://www.readbyqxmd.com/read/29403256/langerhans-cell-histiocytosis-as-an-unusual-cause-of-back-pain-in-a-child-a-case-report-and-review-of-literature
#6
Hemaswetha Balachandran, Latha M Sneha, Gopinath Menon, Julius Scott
Low back pain in children and adolescents are usually attributed to mechanical causes and faulty positions. Although most of them are self-limiting, physicians should be aware of the red flag signs that warrant complete evaluation to rule out malignant causes of back pain. As delay in the diagnosis of vertebral lytic lesion may have sequelae in the growing children, pain disproportionate to the signs should have low threshold levels for evaluation. We report a case of 6-year-old boy who presented with worsening back pain...
October 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29401073/growth-friendly-surgery-and-serial-cast-correction-in-the-treatment-of-early-onset-scoliosis-for-patients-with-prader-willi-syndrome
#7
Jonathan Oore, Braydon Connell, Burt Yaszay, Amer Samdani, Tricia St Hilaire, Tara Flynn, Ron El-Hawary
BACKGROUND: Prader-Willi syndrome (PWS) patients can present with scoliosis which can be treated with serial cast correction (SCC) or with growth friendly surgery (GFS). This study's purpose was to describe the results of SCC as well as GFS for PWS patients with early-onset scoliosis (EOS). METHODS: PWS patients were identified from 2 international multicenter EOS databases. Scoliosis, kyphosis, spine height (T1-S1), right/left hemithoracic heights/widths (RHTH, LHTH, RHTW, LHTW) were measured pretreatment, postoperation, and at 2-year follow-up...
February 2, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29393831/a-historical-recount-of-chordoma
#8
Ronald Sahyouni, Khodayar Goshtasbi, Amin Mahmoodi, Jefferson W Chen
Chordoma, a rare bone tumor that occurs along the spine, has led scientists on a fascinating journey of discoveries. In this historical vignette, the authors track these discoveries in diagnosis and treatment, noting events and clinicians that played pivotal roles in our current understanding of chordoma. The study of chordoma begins in 1846 when Rudolf Virchow first observed its occurrence on a dorsum sellae; he coined the term "chordomata" 11 years later. The chordoma's origin was greatly disputed by members of the scientific community...
February 2, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29390517/cervical-digit-in-a-child-a-case-report
#9
Min-Ji Tong, Guang-Heng Xiang, Zi-Li He, Hua-Zi Xu, Nai-Feng Tian
BACKGROUND: A "digit-like" bone is a rare developmental anomaly that is usually seen in the pelvic or thoracic regions. Such an anomaly in the cervical spine is extremely rare and few cases have been reported. We present a patient with an anomalous bone posterior to a cervical vertebra. The patient was admitted to our hospital with a gradually growing hard neck mass and esthetic complaints. Physical examination, radiographs, reconstructed computed tomography, and magnetic resonance imaging revealed a digit-like bone posterior to the cervical spine...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29389720/complication-severity-score-for-growth-friendly-surgery-has-strong-interrater-and-intrarater-agreement
#10
Nicole Michael, Claire Palmer, John T Smith, Zhaoxing Pan, Tricia St Hilaire, Jessica Morgan, Victoria Heagy, Sumeet Garg
BACKGROUND: Growth-friendly surgery has high complication rates. The Complication Severity Score for growth-friendly surgery was developed to maintain consistency while reporting complications as part of research in this rapidly evolving field. This study evaluates the interrater and intrarater reliability of this complication classification system. METHODS: After Institutional Review Board approval, complications during treatment for early onset scoliosis were identified from a prospectively collected database...
January 31, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29372371/surgical-treatment-of-patients-with-myelomeningocele-related-spine-deformities-study-of-26-cases
#11
Huseyin Canaz, Ibrahim Alatas, Gokhan Canaz, Gurkan Gumussuyu, Mehmet Akif Cacan, Ayten Saracoglu, Bekir Yavuz Ucar
INTRODUCTION: Scoliosis, kyphosis, and sacral agenesis (SA) are common spine deformities in myelomeningocele (MMC) patients. Surgery of spine deformities in MMC patients is associated with various difficulties as infection, pathological skin breakage, instrumentation failure, and neurological deterioration. The purposes of this study are to share our clinical experience and discuss different surgical techniques which are defined in the literature. PATIENTS AND METHOD: We retrospectively evaluated our database of patients with MMC who underwent surgical procedures for spine deformities from 2014 to 2016...
January 25, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29337630/ethnic-differences-in-craniofacial-and-upper-spine-morphology-in-children-with-skeletal-class-ii-malocclusion
#12
Eunhye Oh, Sug-Joon Ahn, Liselotte Sonnesen
OBJECTIVES: To analyze differences in upper cervical spine and craniofacial morphology, including posterior cranial fossa and growth prediction signs, between Danish and South Korean pre-orthodontic skeletal Class II children and to analyze associations between upper cervical spine morphology and craniofacial characteristics. MATERIALS AND METHODS: One hundred forty-six skeletal Class II children-93 Danes (54 boys and 39 girls, mean age 12.2 years) and 53 Koreans (27 boys and 26 girls, mean age 10...
January 16, 2018: Angle Orthodontist
https://www.readbyqxmd.com/read/29325333/-biomechanical-effects-on-adjacent-segments-of-different-growing-rod-fixation-in-early-onset-scoliosis
#13
Y Hai, A X Pan, Y G Li, L Zang, S Yuan
Objective: To analyse the biomechanical effects on adjacent segments of different growing-rod (GR) fixation in early onset scoliosis through a finite element analysis method. Methods: A severe early-onset scoliosis patient was selected and the pre-operation and post-GR-operation (Upper instrumented levels: T(4), T(5). Lower instrumented levels: L(3), L(4)) whole spine 3-dimentional CT scan data were collected to build the finite models. Based on the different models, biomechanical differences on adjacent segments were analysed...
December 26, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29319661/observed-length-increases-of-magnetically-controlled-growing-rods-are-lower-than-programmed
#14
Sarah E Gilday, Mark S Schwartz, Donita I Bylski-Austrow, David L Glos, Lindsay Schultz, Sara O'Hara, Viral V Jain, Peter F Sturm
BACKGROUND: Magnetically controlled growing rods (MCGRs) are increasingly used in the treatment of early onset scoliosis (EOS). Few studies have reported whether desired lengthening can reliably be achieved, or if prior spine instrumentation and large tissue depths affect lengthening. In this clinical study of EOS patients, it was hypothesized that increases in rod length would equal programmed increases, patients with prior spine instrumentation would lengthen less than patients without prior surgery, and larger tissue depths would decrease lengthening success...
January 9, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29315128/parallel-proximal-fixation-in-rib-based-growing-rod-system-a-novel-approach-to-deal-with-proximal-anchor-migration
#15
John Heflin, Michelle Welborn, Norman Ramirez-Lluch, Ivan Iriarte, Ron El-Hawary, Graham T Fedorak, John T Smith
STUDY DESIGN: Retrospective case control OBJECTIVE.: To report on differences in implant failure rates and complications requiring reoperation in children with early-onset scoliosis (EOS) treated with rib-based distraction utilizing four proximal fixation points in either a parallel or in-line configuration. SUMMARY OF BACKGROUND DATA: Proximal anchor failure continues to be a significant problem in growth-friendly surgery using rib-based distraction to treat children with EOS...
January 8, 2018: Spine
https://www.readbyqxmd.com/read/29313554/a-better-method-for-repairing-lumbar-dural-tears-a-review-of-the-literature
#16
Evan Mullen, John Caridi, Jeremy R Steinberge, Raj Shrivastava
Although dural tears are a frequent complication of lumbar spine surgery, no standardized method exists for their treatment. Given the growing number of spinal procedures performed worldwide, it is important to codify an effective strategy for managing repair of the dura mater. This paper is a review of the comparative effectiveness of the current treatments available for dural tears. Our findings suggest that, where possible, repair should be made via direct suturing using material that minimizes the difference between the size of needle and thread...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29306972/text-neck-and-neck-pain-in-18-21-year-old-young-adults
#17
Gerson Moreira Damasceno, Arthur Sá Ferreira, Leandro Alberto Calazans Nogueira, Felipe José Jandre Reis, Igor Caio Santana Andrade, Ney Meziat-Filho
PURPOSE: The aim of this study was to investigate whether there is an association between text neck and neck pain in young adults. METHODS: Observational cross-sectional study with 150 18-21-year-old young adults from a public high school in the state of Rio de Janeiro was performed. In the self-report questionnaire, the participants answered questions on sociodemographic factors, anthropometric factors, time spent texting or playing on a mobile phone, visual impairments, and concern with the body posture...
January 6, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29299490/osteoporosis-and-the-management-of-spinal-degenerative-disease-ii
#18
REVIEW
Félix Tomé-Bermejo, Angel R Piñera, Luis Alvarez
Osteoporosis has become a major medical problem as the aged population of the world rapidly grows. Osteoporosis predisposes patients to fracture, progressive spinal deformities, and stenosis, and is subject to be a major concern before performing spine surgery, especially with bone fusions and instrumentation. Osteoporosis has often been considered a contraindication for spinal surgery, while in some instances patients have undergone limited and inadequate procedures in order to avoid concomitant instrumentation...
November 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29287816/comparison-of-percentile-weight-gain-of-growth-friendly-constructs-in-early-onset-scoliosis
#19
Liam R Harris, Lindsay M Andras, Paul D Sponseller, Charles E Johnston, John B Emans, David L Skaggs
STUDY DESIGN: Multicenter retrospective cohort. OBJECTIVE: To compare improvement in nutritional status seen in early-onset scoliosis (EOS) patients following treatment with various growth-friendly techniques, especially in underweight patients (<20th weight percentile). BACKGROUND: Thoracic insufficiency resulting from EOS can lead to severe cardiopulmonary disease. In this age group, pulmonary function tests are often difficult or impossible to perform...
January 2018: Spine Deformity
https://www.readbyqxmd.com/read/29282746/valve-morphogenesis-in-diploneis-smithii-bacillariophyta
#20
Masahiko Idei, Shinya Sato, Tamotsu Nagumo, David G Mann
Diploneis species have perhaps the most complex valve structure among pennate diatoms. The development of this structure was studied in D. smithii and begins with the formation of a primary band, which then develops secondary arms at both poles and the center, as in the classic Chiappino-Volcani model of raphid diatom ontogeny. Spine-like projections grow out from the primary band and secondary arms to establish the transapical ribs (virgae) of the mature valve and themselves develop spines, which are spaced first oppositely and then alternately and fuse with each other to delimit the stria pores...
December 28, 2017: Journal of Phycology
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