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Growing spine

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https://www.readbyqxmd.com/read/28622904/radiographic-outcomes-of-shilla-growth-guidance-system-and-traditional-growing-rods-through-definitive-treatment
#1
Scott J Luhmann, June C Smith, Ann McClung, Frances L McCullough, Richard E McCarthy, George H Thompson
STUDY DESIGN: Retrospective review of a multicenter database. OBJECTIVES: To compare the radiographic outcomes of patients who had undergone the Shilla Growth Guidance System (SGGS) and traditional growing rod (GR) treatment for management of early-onset scoliosis (EOS) through definitive treatment. SUMMARY OF BACKGROUND DATA: The efficacy of surgical treatment of EOS can only be determined after definitive treatment has been completed. We wanted to review our experience with the SGGS and GR for management of EOS through definitive treatment...
July 2017: Spine Deformity
https://www.readbyqxmd.com/read/28614590/chronic-ethanol-during-adolescence-impacts-corticolimbic-dendritic-spines-and-behavior
#2
Nicholas J Jury, Gabrielle A Pollack, Meredith J Ward, Jessica L Bezek, Alexandra J Ng, Courtney R Pinard, Hadley C Bergstrom, Andrew Holmes
BACKGROUND: Risk for alcohol use disorders (AUDs) in adulthood is linked to alcohol drinking during adolescence, but understanding of the neural and behavioral consequences of alcohol exposure during adolescence remains incomplete. Here, we examined the neurobehavioral impact of adolescent chronic intermittent EtOH (CIE) vapor exposure in mice. METHODS: C57BL/6J-background Thy1-EGFP mice were CIE-exposed during adolescence or adulthood and examined, as adults, for alterations in the density and morphology of dendritic spines in infralimbic (IL) cortex, prelimbic (PL) cortex, and basolateral amygdala (BLA)...
June 14, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28614287/nasal-swab-screening-for-staphylococcus-aureus-in-spinal-deformity-patients-treated-with-growing-rods
#3
Scott J Luhmann, June C Smith
BACKGROUND: Surgical-site infections are one of the most concerning complications in patients treated with growing rods (GR). The purpose of this study was to evaluate the use of preoperative screening for Staphylococcus aureus (SA) for all growing spine procedures, and if this would permit alteration of prophylactic antibiotics to cover the identified resistances. METHODS: All patients were identified who had SA screening during the course of GR treatment. In otal, 34 patients [23 neuromuscular (NMS), 4 congenital, 4 idiopathic scoliosis (IS), and 3 syndromic] were identified who had 111 preoperative screenings [79 lengthenings, 23 insertions, 6 revisions, and 3 conversions to posterior spinal fusions (PSF)]...
June 13, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28609322/thoracic-spine-growth-revisited-how-accurate-is-the-dimeglio-data
#4
Ozgur Dede, Kadir Büyükdoğan, Halil Gökhan Demirkıran, Erhan Akpınar, Muharrem Yazici
STUDY DESIGN: Cross-sectional descriptive study. OBJECTIVE: To describe the normal rate pattern of thoracic spine growth in children without any spinal deformity. SUMMARY OF BACKGROUND DATA: The knowledge of thoracic spine growth and height is important for growing spine treatment and the decision of final fusion. Currently, pediatric spinal deformity is approached as early onset and late onset with an understanding of the fast growth during the first 5 years of life...
June 15, 2017: Spine
https://www.readbyqxmd.com/read/28608177/ten-year-follow-up-of-jarcho-levin-syndrome-with-thoracic-insufficiency-treated-by-veptr-and-mcgr-veptr-hybrid
#5
Kenny Yat Hong Kwan, Jason Pui Yin Cheung, Karen Kar Lum Yiu, Kenneth Man Chee Cheung
PURPOSE: Jarcho-Levin syndrome patients commonly suffer from repeated respiratory infections and become ventilator dependent due to an insufficient thoracic volume. Multiple congenital vertebral anomalies are associated with this genetic disorder and results in stunted spine growth. The purpose of this case report is to present the results of a hybrid vertical expandable prosthetic titanium rib (VEPTR) and magnetically controlled growing rod (MCGR) construct for the management of a patient with Jarcho-Levin syndrome...
June 12, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28604490/health-related-quality-of-life-in-early-onset-scoliosis-patients-treated-surgically-eosq-scores-in-traditional-growing-rod-vs-magnetically-controlled-growing-rods
#6
Michael E Doany, Z Deniz Olgun, Gizem Irem Kinikli, Senol Bekmez, Aykut Kocyigit, Gokhan Demirkiran, A Ergun Karaagaoglu, Muharrem Yazici
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To compare quality of life and caregiver burden in TGR and MCGR patients. SUMMARY OF BACKGROUND DATA: Magnetic controlled growing rods (MCGR) decrease surgical sessions associated with treatment of early onset scoliosis (EOS), hoping to minimize the burdens seen with repetitive invasive surgeries in traditional growing rod (TGR) treatment. Although the clinical indications for these treatments have largely been agreed upon, there is a lack of understanding of their impact on patients' and families' quality of life...
June 9, 2017: Spine
https://www.readbyqxmd.com/read/28603566/current-concepts-in-pediatric-cervical-spine-trauma
#7
Kunal Shah, Agnivesh Tikoo, Manish K Kothari, Abhay Nene
BACKGROUND: Pediatric spinal trauma is rare and challenging entity. Although cervical spine is commonly affected, it is often missed on routine imaging investigations. Therefore better understanding of growing spine and its patho-physiology is crucial. METHODS: Articles related to pediatric cervical trauma were searched on Pubmed and other online research data banks. We have summarized unique anatomy of pediatric spine, investigations followed by common injury patterns, their diagnostic challenges and management...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28601333/variability-in-ct-imaging-of-blunt-trauma-among-ed-physicians-surgical-residents-and-trauma-surgeons
#8
Melissa K James, Shi-Wen Lee, Jennifer A Minneman, Maureen D Moore, Taylor R Klein, R Jonathan Robitsek, Phillip S Barie, Sebastian D Schubl
BACKGROUND: Trauma triage decisions can be influenced by both knowledge and experience. Consequently, there may be substantial variability in computed tomography (CT) scans desired by emergency medicine physicians, surgical chief residents, and attending trauma surgeons. We quantified this difference and studied the effects of each group's decisions on missed injuries, cost, and radiation exposure. METHODS: All blunt trauma activations at an urban level 1 trauma center were studied over a 6-mo period...
June 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28598292/effects-of-primary-and-recurrent-sacral-chordoma-on-the-motor-and-nociceptive-function-of-hindlimbs-in-rats-an-orthotopic-spine-model
#9
Rachel Sarabia-Estrada, Alejandro Ruiz-Valls, Sagar R Shah, A Karim Ahmed, Alvaro A Ordonez, Fausto J Rodriguez, Hugo Guerrero-Cazares, Ismael Jimenez-Estrada, Esteban Velarde, Betty Tyler, Yuxin Li, Neil A Phillips, C Rory Goodwin, Rory J Petteys, Sanjay K Jain, Gary L Gallia, Ziya L Gokaslan, Alfredo Quinones-Hinojosa, Daniel M Sciubba
OBJECTIVE Chordoma is a slow-growing, locally aggressive cancer that is minimally responsive to conventional chemotherapy and radiotherapy and has high local recurrence rates after resection. Currently, there are no rodent models of spinal chordoma. In the present study, the authors sought to develop and characterize an orthotopic model of human chordoma in an immunocompromised rat. METHODS Thirty-four immunocompromised rats were randomly allocated to 4 study groups; 22 of the 34 rats were engrafted in the lumbar spine with human chordoma...
June 9, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28596580/flower-induction-microscope-aided-cross-pollination-and-seed-production-in-the-duckweed-lemna-gibba-with-discovery-of-a-male-sterile-clone
#10
Lili Fu, Meng Huang, Bingying Han, Xuepiao Sun, K Sowjanya Sree, Klaus-J Appenroth, Jiaming Zhang
Duckweed species have a great potential to develop into fast-growing crops for water remediation and bioenergy production. Seed production and utilization of hybrid vigour are essential steps in this process. However, even in the extensively-studied duckweed species, Lemna gibba, flower primordia were often aborted prior to maturation. Salicylic acid (SA) and agar solidification of the medium promoted flower maturation and resulted in high flowering rates in L. gibba 7741 and 5504. Artificial cross-pollination between individuals of L...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28594523/congenital-scoliosis-a-case-based-approach
#11
Frances A Farley, Laurel C Blakemore
Congenital scoliosis is lateral curvature of the spine caused by vertebral anomalies. Congenital scoliosis is associated with congenital anomalies of other organ systems. Traditionally, treatment options for patients with congenital scoliosis focused on posterior spinal fusion. Current surgical treatment options for young children include growing rods, vertical expandable prosthetic titanium ribs, and, most recently, magnetic rods. Hemivertebrae resection is an important early treatment option for patients who have a hemivertebra...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28587051/evaluating-intensity-modulated-proton-therapy-relative-to-passive-scattering-proton-therapy-for-increased-vertebral-column-sparing-in-craniospinal-irradiation-in-growing-pediatric-patients
#12
Drosoula Giantsoudi, Joao Seco, Bree R Eaton, F Joseph Simeone, Hanne Kooy, Torunn I Yock, Nancy J Tarbell, Thomas F DeLaney, Judith Adams, Harald Paganetti, Shannon M MacDonald
PURPOSE: At present, proton craniospinal irradiation (CSI) for growing children is delivered to the whole vertebral body (WVB) to avoid asymmetric growth. We aimed to demonstrate the feasibility and potential clinical benefit of delivering vertebral body sparing (VBS) versus WVB CSI with passively scattered (PS) and intensity modulated proton therapy (IMPT) in growing children treated for medulloblastoma. METHODS AND MATERIALS: Five plans were generated for medulloblastoma patients, who had been previously treated with CSI PS proton radiation therapy: (1) single posteroanterior (PA) PS field covering the WVB (PS-PA-WVB); (2) single PA PS field that included only the thecal sac in the target volume (PS-PA-VBS); (3) single PA IMPT field covering the WVB (IMPT-PA-WVB); (4) single PA IMPT field, target volume including thecal sac only (IMPT-PA-VBS); and (5) 2 posterior-oblique (-35°, +35°) IMPT fields, with the target volume including the thecal sac only (IMPT2F-VBS)...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28582275/acute-isolated-paraplegia-revealing-an-ewing-sarcoma-of-the-thoracic-spine
#13
Pierre-Aurélien Beuriat, Sarah Melloul, Louise Galmiche, Irene Cristofori, Michel Zerah, Kevin Beccaria
Ewing sarcoma (ES) infrequently affects the spine. Diagnosis is usually made several weeks following growing symptoms. In this report, we present the case of a child with ES localized at the upper thoracic level. ES was revealed by isolated acute complete paraplegia mimicking medullary stroke. The girl was operated for decompressive laminectomy and tumor removal. Afterwards, she received adjuvant therapy. Subsequently, the child showed a slow improvement of her leg sensitivity associated with a partial motor recovery...
June 2, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28572150/percutaneous-spinal-ablation-in-a-sheep-model-protective-capacity-of-an-intact-cortex-correlation-of-ablation-parameters-with-ablation-zone-size-and-correlation-of-postablation-mri-and-pathologic-findings
#14
A N Wallace, T J Hillen, M V Friedman, Z S Zohny, B H Stephens, S C Greco, M R Talcott, J W Jennings
BACKGROUND AND PURPOSE: Despite the growing use of percutaneous ablation therapy for the treatment of metastatic spine disease, several issues have yet to be fully addressed. Our aims were to determine whether the vertebral body cortex protects against ablation-induced spinal cord injury; correlate radiofrequency, cryo-, and microwave ablation parameters with resulting spinal ablation zone dimensions and describe normal spinal marrow postablation changes on MR imaging. MATERIALS AND METHODS: Ten thoracolumbar vertebrae in 3 sheep were treated with radiofrequency ablation, cryoablation, or microwave ablation under fluoroscopic guidance...
June 1, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28571568/environmental-temperature-variation-influences-fitness-trade-offs-and-tolerance-in-a-fish-tapeworm-association
#15
Frederik Franke, Sophie A O Armitage, Megan A M Kutzer, Joachim Kurtz, Jörn P Scharsack
BACKGROUND: Increasing temperatures are predicted to strongly impact host-parasite interactions, but empirical tests are rare. Host species that are naturally exposed to a broad temperature spectrum offer the possibility to investigate the effects of elevated temperatures on hosts and parasites. Using three-spined sticklebacks, Gasterosteus aculeatus L., and tapeworms, Schistocephalus solidus (Müller, 1776), originating from a cold and a warm water site of a volcanic lake, we subjected sympatric and allopatric host-parasite combinations to cold and warm conditions in a fully crossed design...
June 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28566388/magnetically-controlled-growing-rods-in-the-treatment-of-early-onset-scoliosis-a-note-of-caution
#16
P R P Rushton, I Siddique, R Crawford, N Birch, M J Gibson, M J Hutton
The MAGnetic Expansion Control (MAGEC) system is used increasingly in the management of early-onset scoliosis. Good results have been published, but there have been recent reports identifying implant failures that may be associated with significant metallosis surrounding the implants. This article aims to present the current knowledge regarding the performance of this implant, and the potential implications and strategies that may be employed to identify and limit any problems. We urge surgeons to apply caution to patient and construct selection; engage in prospective patient registration using a spine registry; ensure close clinical monitoring until growth has ceased; and send all explanted MAGEC rods for independent analysis...
June 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28565896/effects-of-magnetically-controlled-growing-rods-surgery-on-pulmonary-function-in-young-subjects-with-spinal-muscular-atrophy-type-2-and-other-neuromuscular-scoliosis
#17
Luca Colombo, Carlotta Martini, Chiara Bersanini, Francesca Izzo, Jorge H Villafañe, Pedro Berjano, Claudio Lamartina
BACKGROUND: The aim of this study was to determine the effects of magnetically controlled growing rods surgery (MCGRS) of the scoliosis on pulmonary function in children with neuromuscular scoliosis. METHODS: Seven patients, 85.7% female (mean ± SD age: 6.7±1.2 years), with neuromuscular scoliosis (4 SMA II, 2 congenital myopathies and 1 VACTER syndrome), received MCGRS of the spine in the thoraco-lumbar area. The outcome measures were clinical features and pulmonary function (forced vital capacity [FVC] and forced expiratory volume in 1st second [FEV1], were collected...
May 31, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28558705/disseminated-cryptococcosis-with-recurrent-multiple-abscesses-in-an-immunocompetent-patient-a-case-report-and-literature-review
#18
Qiaoling Ruan, Yimin Zhu, Shu Chen, Liping Zhu, Shu Zhang, Wenhong Zhang
BACKGROUND: Cryptococcus neoformans is frequently present as an opportunistic pathogen mainly affecting immunocompromised populations. Disseminated C. neoformans infection in immunocompetent population is rare and usually involves lung and central nerve system. Cryptococcus from biologic samples can easily grow on routine fungal and bacterial culture media. Besides, cryptococcal latex agglutination test has been established as a reliable diagnostic tool with overall sensitivities of 93-100%...
May 30, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28548698/novel-porcine-experimental-model-of-severe-progressive-thoracic-scoliosis-with-compensatory-curves-induced-by-interpedicular-bent-rigid-temporary-tethering
#19
Carlos Barrios, José Miguel Lloris, Juan Alonso, Borja Maruenda, Jesús Burgos, Rafael Llombart-Blanco, Luis Gil, Viviana Bisbal
Using flexible tethering techniques, porcine models of experimental scoliosis have shown scoliotic curves with vertebral wedging but very limited axial rotation. The aim of this experimental work was to induce a severe progressive scoliosis in a growing porcine model for research purposes. A unilateral spinal bent rigid tether was anchored to two ipsilateral pedicle screws in eight pigs. The spinal tether was removed after 8 weeks. Ten weeks later, the animals were sacrificed. Conventional radiographs and 3D CT-scans were taken to evaluate changes in the alignment of the thoracic spine...
May 26, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28543027/the-vascularized-groin-lymph-node-flap-vgln-anatomical-study-and-flap-planning-using-multi-detector-ct-scanner-the-golden-triangle-for-flap-harvesting
#20
Assaf A Zeltzer, Alexander Anzarut, Delphine Braeckmans, Katrin Seidenstuecker, Benoit Hendrickx, Eddy Van Hedent, Moustapha Hamdi
INTRODUCTION: A growing number of surgeons perform lymph node transfers for the treatment of lymphedema. When harvesting a vascularized lymph node groin flap (VGLNF) one of the major concerns is the potential risk of iatrogenic lymphedema of the donor-site. This article helps understanding of the lymph node distribution of the groin in order to minimize this risk. MATERIALS AND METHODS: Fifty consecutive patients undergoing abdominal mapping by multi-detector CT scanner were included and 100 groins analyzed...
May 25, 2017: Journal of Surgical Oncology
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