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https://www.readbyqxmd.com/read/29458229/primary-closure-versus-bedside-silo-and-delayed-closure-for-gastroschisis-a-truncated-prospective-randomized-trial
#1
Ashwini S Poola, Pablo Aguayo, Jason D Fraser, Richard J Hendrickson, Katrina L Weaver, Katherine W Gonzalez, Shawn D St Peter
BACKGROUND: We report a prospective randomized trial comparing primary closure (PC) to bedside silo and delayed closure (DC) for babies with gastroschisis. METHODS: Patients were randomized to PC versus DC. We excluded those with atresia/necrosis, <34 weeks' gestation, or congenital anomalies. The primary outcome was length of stay (LOS). RESULTS: A total of 38 patients were included from August 2011 to August 2016; 18 patients underwent DC and 20 PC...
February 19, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29457941/the-impact-of-nurse-managers-leadership-styles-on-ward-staff
#2
Usama Saleh, Tom O'Connor, Hattan Al-Subhi, Rana Alkattan, Saad Al-Harbi, Declan Patton
AIM: to explore the nature of leadership styles used by the nursing management team, as perceived by nurses working at the bedside. BACKGROUND: leadership style is related to job satisfaction, staff retention, costs, and quality of care. The leadership styles of managers can be crucial in the healthcare setting, but very few studies have focused on them. METHOD: the study employed qualitative methodology, involving 35 nurses working in different specialties of a medical city in Saudi Arabia...
February 22, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29457379/levels-of-cytokines-and-micrornas-in-individuals-with-asymptomatic-hyperuricemia-and-ultrasonographic-findings-of-gout-a-bench-to-bedside-approach
#3
Irving O Estevez-Garcia, Selma Gallegos-Nava, Erika Vera-Pérez, Luis H Silveira, Lucio Ventura-Ríos, Gonzalo Vancini, Cristina Hernández-Díaz, Fausto Sánchez-Muñoz, Martha A Ballinas-Verdugo, Marwin Gutierrez, Carlos Pineda, Pedro Rodriguez-Henriquez, Diana Castillo-Martínez, Luis M Amezcua-Guerra
OBJECTIVE: To assess potential associations among serum cytokines and microRNA (miR) levels with ultrasound (US) findings suggestive of urate deposits in chronic asymptomatic hyperuricemia and gout. METHODS: All participants underwent musculoskeletal US and measurements of serum IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IFN-γ, TNF, MCP-1, and ENA-78, as well as miR-146a, miR-155, and miR-223 levels. RESULTS: Thirty individuals with asymptomatic hyperuricemia, 31 normouricemic controls, and 30 gouty patients were included...
February 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29457236/time-is-ethics
#4
Mark Mercurio
Early in my career as a neonatologist, I was called into the hospital for a newborn who would not stop crying. Screaming, really. When I entered the unit, I was greeted by a loud, shrill, distinctive cry. After hearing the history and examining the baby, I just stood there for a while, watching and listening. It took some time, but eventually, I noticed a subtle regularity, a rhythmicity. I took off my watch, placed it on the bed next to the child, and found that the crying briefly grew louder about every six or seven seconds...
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29454464/prodrugs-phospholipids-and-vesicular-delivery-an-effective-triumvirate-of-pharmacosomes
#5
REVIEW
Bhupinder Kapoor, Reena Gupta, Sachin Kumar Singh, Monica Gulati, Saranjit Singh
With the advent from the laboratory bench to patient bedside in last five decades, vesicular systems have now come to be widely accepted as pragmatic means for controlled delivery of drugs. Their success stories include those of liposomes, niosomes and even the lately developed ethosomes and transferosomes. Pharmacosomes, which, as delivery systems offer numerous advantages and have been widely researched, however, remain largely unacknowledged as a successful delivery system. Though a large number of drugs have been derivatized and formulated into self-assembled vesicular systems, the term pharmacosomes has not been widely used while reporting them...
February 7, 2018: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/29454063/characterization-of-nanomedicines-a-reflection-on-a-field-under-construction-needed-for-clinical-translation-success
#6
REVIEW
Jean-Baptiste Coty, Christine Vauthier
The nanotechnology revolution offers many expectations for the improvement of medicine treatments. At present, nanomedicine (NM) development is hampered by methodological barriers for a better characterization and a wider understanding of their in vivo behavior. While regulatory agencies setup guidelines to support NM translation from bench to bedside, the gap is still hardly overcome by main nanomedicines. One lever for filling this gap is a better characterization, thus increasing the global knowledge about the NM itself but also validate the confidence in terms of batch to batch reproducibility of such complex nano-objects...
February 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29451697/optimizing-case-reports-and-case-series-guidance-on-how-to-improve-quality
#7
REVIEW
I Garcia-Doval, J Albrecht, C Flohr, J Batchelor, J R Ingram
Case reports and case series remain an important part of journals and are often first to document medical breakthroughs. This article reviews their characteristics, aims and limitations. It provides information on how to increase the validity of the bedside decision-making process that these studies report, using tools such as validated outcomes and split body or n-of-1 trials. A section describing tools to improve writing of case reports and case series provides suggestions for detailed reporting and good evaluation of novelty, validity and relevance...
February 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29451202/stem-cells-for-spinal-cord-injuries-bearing-translational-potential
#8
REVIEW
Kyriakos Dalamagkas, Magdalini Tsintou, Alexander M Seifalian
Spinal cord injury (SCI) is a highly debilitating neurological disease, which still lacks effective treatment strategies, causing significant financial burden and distress to the affected families. Nevertheless, nanotechnology and regenerative medicine strategies holding promise for the development of novel therapies that would reach from bench to bedside to serve the SCI patients. There has already been significant progress in the field of cell-based therapies, with the clinical application for SCI, currently in phase II of the clinical trial...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29449546/a-community-approach-to-mortality-prediction-in-sepsis-via-gene-expression-analysis
#9
Timothy E Sweeney, Thanneer M Perumal, Ricardo Henao, Marshall Nichols, Judith A Howrylak, Augustine M Choi, Jesús F Bermejo-Martin, Raquel Almansa, Eduardo Tamayo, Emma E Davenport, Katie L Burnham, Charles J Hinds, Julian C Knight, Christopher W Woods, Stephen F Kingsmore, Geoffrey S Ginsburg, Hector R Wong, Grant P Parnell, Benjamin Tang, Lyle L Moldawer, Frederick E Moore, Larsson Omberg, Purvesh Khatri, Ephraim L Tsalik, Lara M Mangravite, Raymond J Langley
Improved risk stratification and prognosis prediction in sepsis is a critical unmet need. Clinical severity scores and available assays such as blood lactate reflect global illness severity with suboptimal performance, and do not specifically reveal the underlying dysregulation of sepsis. Here, we present prognostic models for 30-day mortality generated independently by three scientific groups by using 12 discovery cohorts containing transcriptomic data collected from primarily community-onset sepsis patients...
February 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29446988/diagnosing-tongue-base-obstruction-in-pierre-robin-sequence-infants-sleep-vs-awake-endoscopy
#10
Jake J Lee, Matthew D Ford, Allison B Tobey, Noel Jabbour
OBJECTIVE: To investigate whether awake endoscopy can diagnose base-of-tongue obstruction as reliably as sleep endoscopy in infants with Pierre Robin sequence (PRS). DESIGN: The study was retrospective with the clinicians blinded to patient identity. Endoscopy findings were assessed and measured by the performing pediatric otolaryngologist. SETTING: Tertiary care children's hospital. PATIENTS: All infants with PRS managed between January 2005 and July 2015 were included...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29446247/molecular-diagnostic-techniques-in-cytopathology-from-the-bench-to-the-patient-s-bedside
#11
Cristina Díaz Del Arco, Mª Jesús Fernández Aceñero
Molecular techniques are increasingly used in everyday practice for patient diagnosis and also to guide therapy. Their application in cytological specimens can allow a more cost-effective management with fewer risks. However, standardized protocols are needed to guarantee accurate and reproducible results. We herein report five practical examples of the application of ancillary techniques in cytopathology and review the literature on the issue, highlighting the practical aspects of sample management.
February 15, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29446052/correction-to-pk-pd-compass-bringing-infectious-diseases-pharmacometrics-to-the-patient-s-bedside
#12
Catharine C Bulik, Justin C Bader, Li Zhang, Scott A Van Wart, Christopher M Rubino, Sujata M Bhavnani, Kim L Sweeney, Paul G Ambrose
The original version of this article contained incorrect Supplementary Files. The correct Supplementary Files are published with this erratum.
February 14, 2018: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/29444696/bedside-analysis-of-the-sublingual-microvascular-glycocalyx-in-the-emergency-room-and-intensive-care-unit-the-glyconurse-study
#13
Alexandros Rovas, Alexander-Henrik Lukasz, Hans Vink, Marc Urban, Jan Sackarnd, Hermann Pavenstädt, Philipp Kümpers
BACKGROUND: Deterioration of the endothelial glycocalyx (eGC), a protective carbohydrate-rich layer lining the luminal surface of the endothelium, plays a key role in vascular barrier dysfunction and eventually organ-failure in systemic inflammatory response syndrome and sepsis. Early detection of glycocalyx damage could thus become an important goal in critical care. This study was designed to determine the feasibility and reproducibility of quantitative, real-time glycocalyx measurements performed at bedside in the emergency room (ER) and intensive care unit (ICU)...
February 14, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29444536/optimizing-the-user-experience-identifying-opportunities-to-improve-use-of-an-inpatient-portal
#14
Daniel M Walker, Terri Menser, Po-Yin Yen, Ann Scheck McAlearney
BACKGROUND:  Patient portals specifically designed for the inpatient setting have significant potential to improve patient care. However, little is known about how the users of this technology, the patients, may interact with the inpatient portals. As a result, hospitals have limited ability to design approaches that support patient use of the portal. OBJECTIVES:  This study aims to evaluate the user experience associated with an inpatient portal. METHODS:  We used a Think-Aloud protocol to study user interactions with a commercially available inpatient portal-MyChart Bedside (MCB)...
January 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29443856/complications-in-tube-thoracostomy-systematic-review-and-meta-analysis
#15
Matthew C Hernandez, Moustafah El Khatib, Larry Prokop, Martin D Zielinski, Johnathon M Aho
BACKGROUND: Tube thoracostomy (TT) complications and their reported rates are highly variable (1-40%) and inconsistently classified. Consistent TT complication classification must be applied to compare reported literature to standardize TT placement. We aim to determine the overall TT related complication rates in patients receiving TT for traumatic indications utilizing uniform definitions. METHOD: Systematic review and meta-analysis was performed assessing TT related complications...
February 14, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29443786/improved-vacuum-sealing-drainage-for-treatment-of-surgical-site-infection-following-posterior-spinal-internal-fixation-a-case-report
#16
Hengyan Zhang, Qiyi Li
RATIONALE: Surgical site infection (SSI) following spine surgeries involving internal fixation often require removing the instrument; however, this can cause spinal instability. Previous reports have demonstrated the usefulness of vacuum sealing drainage (VSD) therapy, but the cases require wound opening, aseptic condition to replace the VSD device, and a secondary operation to close the wound. Thus, to improve the VSD treatment and develop a maneuverable procedure, make sense in spine surgery...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29442038/non-viral-gene-delivery-systems-hurdles-for-bench-to-bedside-transformation
#17
N A Helal, A Osami, A Helmy, T McDonald, L A Shaaban, M I Nounou
Biologist and Nobel Prize winner James Watson's quote, "We used to think that our fate was in our stars, but now we know that, in large measure, our fate is in our genes", represents the initial food for thought that revolutionized the way medications and active pharmaceutical ingredients are defined (Rocholl 1996). This fate engraved in the genetic material, as mentioned in Watson's quote, fueled a tremendous revolution wave in gene therapy. Gene therapy is a promising technology for treating genetic and acquired diseases by modulating the expression of a specific gene in the pathological cells...
November 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441815/the-secret-drama-at-the-patient-s-bedside-refusal-of-treatment-because-of-the-practitioner-s-ethnic-identity-the-medical-staff-s-point-of-view
#18
Ariela Popper-Giveon, Yael Keshet
Patients' refusal of treatment based on the practitioner's ethnic identity reveals a clash of values: neutrality in medicine versus patient-centered care. Taking the Israeli-Palestinian conflict into account, this article aims at examining Israeli health care professionals' points of view concerning patients' refusal of treatment because of a practitioner's ethnic identity. Fifty in-depth interviews were conducted with 10 managers and 40 health care professionals, Jewish and Arab, employed at 11 public hospitals...
February 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29441421/diagnostic-error-in-stroke-reasons-and-proposed-solutions
#19
REVIEW
Ekaterina Bakradze, Ava L Liberman
PURPOSE OF REVIEW: We discuss the frequency of stroke misdiagnosis and identify subgroups of stroke at high risk for specific diagnostic errors. In addition, we review common reasons for misdiagnosis and propose solutions to decrease error. RECENT FINDINGS: According to a recent report by the National Academy of Medicine, most people in the USA are likely to experience a diagnostic error during their lifetimes. Nearly half of such errors result in serious disability and death...
February 13, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29438568/haemodynamic-assessment-and-support-in-sepsis-and-septic-shock-in-resource-limited-settings
#20
David Misango, Rajyabardhan Pattnaik, Tim Baker, Martin W Dünser, Arjen M Dondorp, Marcus J Schultz
Background: Recommendations for haemodynamic assessment and support in sepsis and septic shock in resource-limited settings are largely lacking. Methods: A task force of six international experts in critical care medicine, all of them members of the Global Intensive Care Working Group of the European Society of Intensive Care Medicine and with extensive bedside experience in resource-limited intensive care units, reviewed the literature and provided recommendations regarding haemodynamic assessment and support, keeping aspects of efficacy and effectiveness, availability and feasibility and affordability and safety in mind...
February 9, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
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