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https://www.readbyqxmd.com/read/29245005/cd19-car-t-cells
#1
Michel Sadelain
CARs are synthetic receptors that reprogram immune cells for therapeutic purposes. They comprise three canonical domains for antigen recognition, T cell activation, and costimulation. The CAR cDNA is genetically integrated in the T cell genome. Autologous CAR T cells are generated from the patient's peripheral blood T cells and expand in the recipient to eliminate the targeted tumor. To view this Bench to Bedside, open or download the PDF.
December 14, 2017: Cell
https://www.readbyqxmd.com/read/29243739/frozen-sections-are-unreliable-for-the-diagnosis-of-necrotizing-soft-tissue-infections
#2
Isaac H Solomon, Rene Borscheid, Alvaro C Laga, Reza Askari, Scott R Granter
Necrotizing soft tissue infections are rare but are associated with high rates of morbidity and mortality. The use of bedside or intraoperative frozen sections has been reported to be associated with faster diagnosis and better outcomes; however, to date no large studies have been published to determine the sensitivity and specificity of frozen sections in this setting. Twenty years of cases suspicious for necrotizing soft tissue infection at a large academic referral center were reviewed, blinded to the final clinical diagnosis (gold standard)...
December 15, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29243561/patient-safety-communication-among-differently-educated-nurses-converging-and-diverging-meaning-systems
#3
Allison Brandt Anbari, Amy Vogelsmeier, Debbie S Dougherty
Studies that suggest an increased number of bachelor's prepared nurses (BSNs) at the bedside improves patient safety do not stratify their samples into traditional bachelor's and associates (ADN) to BSN graduates. This qualitative study investigated potential differences in patient safety meaning among BSNs and ADN to BSN graduates. Guided by the theory of Language Convergence/Meaning Divergence, interview data from eight BSN and eight ADN to BSN graduates were analyzed. Findings indicate there are two meaning levels or systems, the local level and the systemic level...
December 1, 2017: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/29242940/clinics-in-diagnostic-imaging-182-acute-descending-aortic-dissection-with-aortic-root-retrograde-extension
#4
John Nathan Gifford, Angeline Choo Choo Poh
A 77-year-old man presented with acute-onset severe chest pain radiating to the back and elevated blood pressure. Multiphasic computed tomography of the aorta revealed an intimal tear in the descending thoracic aorta which extended both retrograde to the aortic root and antegrade to the infra-renal abdominal aorta. The initial impression, that the images showed a Stanford type B aortic dissection, was because the portion of the false lumen that extended beyond the aortic arch remained unopacified even on delayed phases, making it challenging to assess the extent of the dissection flap...
December 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/29241812/exploiting-the-therapeutic-potential-of-ready-to-use-drugs-repurposing-antibiotics-against-amyloid-aggregation-in-neurodegenerative-diseases
#5
REVIEW
Sergio B Socias, Florencia Gonzalez-Lizarraga, Cesar L Avila, Cecilia Vera, Leonardo Acuña, Julia E Sepulveda-Diaz, Elaine Del-Bel, Rita Raisman-Vozari, Rosana N Chehin
Neurodegenerative diseases are chronic and progressive disorders that affect specific regions of the brain, causing gradual disability and suffering that results in a complete inability of patients to perform daily functions. Amyloid aggregation of specific proteins is the most common biological event that is responsible for neuronal death and neurodegeneration in various neurodegenerative diseases. Therapeutic agents capable of interfering with the abnormal aggregation are required, but traditional drug discovery has fallen short...
December 11, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/29241347/hospital-based-clinicians-perceptions-of-geographic-cohorting-identifying-opportunities-for-improvement
#6
Areeba Kara, Cynthia S Johnson, Siu L Hui, Deanne Kashiwagi
Members of the Society of Hospital Medicine were surveyed about geographic cohorting (GCh); 369 responses were analyzed, two thirds of which were from GCh participants. Improved collaboration with the bedside nurse, increased nonclinical interactions, decreased paging interruptions, and improved efficiency were perceived by >50%. Narrowed clinical expertise, increased fragmentation, increased face-to-face interruptions, and an adverse impact on camaraderie within the hospitalist group were reported by 25% to 50%...
December 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/29241303/body-fluid-status-assessment-by-bio-impedance-analysis-in-patients-presenting-to-the-emergency-department-with-dyspnea
#7
Chan Soon Park, Sang-Eun Lee, Hyun-Jai Cho, Yong-Jin Kim, Hyun-Jae Kang, Byung-Hee Oh, Hae-Young Lee
Background/Aims: Fluid retention occurs in patients with heart failure, accounting for dyspnea. We investigated the diagnostic implication of body fluid status, assessed by bio-impedance analysis (BIA), in acute heart failure (AHF) among patients who presented with dyspnea. Methods: A total of 100 patients who presented with dyspnea and suspected with AHF were analyzed in this study. We enrolled 50 AHF and 50 non-AHF patients discriminated through echocardiographic analysis and Framingham criteria and were matched by age and sex...
December 18, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29241119/bench-to-bedside-review-possible-role-of-vitamin-d-in-autism-spectrum-disorder
#8
REVIEW
Feiyong Jia, Ling Shan, Bing Wang, Honghua Li, Chunyue Miao, Zhida Xu, Ching-Po Lin, Khaled Saad
Autism spectrum disorder (ASD) is a group of dysfunctions in social interaction, communication, and behaviors. Studies have demonstrated that vitamin D deficiency during pregnancy and in individuals increased the risk of ASD. A genetic polymorphism study has pinpointed that genotype AA/A-allele of GC rs4588 in children is associated with ASD, which encodes the vitamin D binding protein. Translating the mentioned points into clinical practice, several clinical trials have demonstrated that vitamin D supplementation can improve the core symptoms in children with ASD...
December 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29240589/infrared-skin-thermometry-validating-and-comparing-techniques-to-detect-periwound-skin-infection
#9
Asfandyar Mufti, Ranjani Somayaji, Patricia Coutts, R Gary Sibbald
OBJECTIVE: Diagnosis of wound infection can be challenging because it relies on a combination of clinical signs and symptoms that are often nonspecific. Increased periwound cutaneous temperature is a classic sign of deep and surrounding wound infection, and its quantitative measurement is one of the most reliable and valid clinical signs of deep and surrounding skin infection at the bedside. Skin surface temperature differences may be detected using commercially available noncontact infrared thermometers...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29240531/enhancing-dignity-for-older-inpatients-the-photograph-next-to-the-bed-study
#10
Ruth E Hubbard, Melissa Bak, Jacqueline Watts, David Shum, Angelica Lynch, Nancye M Peel
OBJECTIVES: Older inpatients compromised by illness and cognitive decline may be stripped of physical and cultural identifiers, making them vulnerable to erosion of dignity. This study explored the experiences of patients, carers and clinical staff in response to a simple intervention that could enhance the dignity of care for older inpatients. METHODS: All patients in a rehabilitation ward were encouraged to have a photograph of themselves next to their bed. Of those who participated, focus groups were recruited for patients, family members and staff to explore their reflections...
November 16, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29240492/interprofessional-bedside-teaching-setting-up-a-novel-teaching-programme
#11
Kathryn Watson, Cathryn Mainwaring, Amy Moran, Fahmeda B Jangi, Nira Raguseelan, Thomas Simpson, Tunjil Lasoye, Omar G Mustafa
BACKGROUND: An ageing population and health-care advances mean that patients have increasingly complex medical health and social needs, requiring a multidisciplinary team. However, despite working as an interprofessional team, team members still largely train in professional silos. Furthermore health-care professionals report a poor understanding of the skills of colleagues from different professions. This article describes the set up and outcomes of a novel interprofessional bedside teaching programme...
December 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29239761/deflate-to-extricate-a-technique-for-rectal-foreign-body-removal-of-inflatable-ball
#12
Elizabeth C Robinson, David Roy, Brian E Driver
BACKGROUND: Rectal foreign bodies are commonly encountered in the emergency department (ED). Three techniques are well described in literature, including using a Foley catheter, "scooping" the object out, or grasping the object directly with ring forceps. We present a novel extraction method for an inflatable foreign body. CASE REPORT: A 27-year-old man presented to the ED 13 h after inserting a rubber inflatable child's ball into his rectum. After well-described extraction techniques failed to remove the ball, an 18-gauge needle at the end of a syringe was inserted into the rectum to puncture the ball and partially deflate it...
November 24, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29239458/treatment-of-advanced-melanoma-a-changing-landscape
#13
Adriana Hepner, Alessandra Salgues, Carlos A Dos Anjos, Marina Sahade, Veridiana P Camargo, Bernardo Garicochea, Alexander N Shoushtari, Michael A Postow, Gustavo S Fernandes, Rodrigo R Munhoz
Following decades of relative ostracism, advances in the treatment of melanoma have brought a new reality for patients, physicians and researchers. While antibodies targeting molecules involved in the modulation of the interaction between melanoma and immune cells changed the meaning of the term "cancer immunotherapy," a better characterization of the molecular aberrations involved in melanoma carcinogenesis prompted the development of inhibitors of the mitogen-activated protein kinase pathway (MAPK) that also led to significant improvements both in response rates and survival...
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29238870/chest-radiograph-measurement-technique-facilitates-accurate-bedside-peripherally-inserted-central-catheter-placement-in-children
#14
Aishu Ramamurthi, Jeffrey Forris Beecham Chick, Rajiv N Srinivasa, Anthony N Hage, Jason J Grove, Joseph J Gemmete, Timothy D Johnson, Ravi N Srinivasa
PURPOSE: To report the chest radiograph measurement technique for placing bedside peripherally inserted central catheters (PICCs). MATERIALS AND METHODS: Two hundred and thirty-two consecutive pediatric patients, mean age of 56.3 months (range: 0-203 months), underwent PICC placement from January 2015 to May 2017 (28 months) with a total of 232 PICCs placed. Measurements were taken from the cavoatrial junction to clavicle, clavicle to medial margin of mid-humeral head, and medial margin of mid-humeral head to mid-humerus...
December 13, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29237669/a-play-that-went-wrong-unique-presentation-of-bowel-perforation-from-an-unusually-large-per-rectal-foreign-body
#15
Saad Ikram, Shailendra Singh, Ramana Kallam, Ajay Dabra
Colorectal foreign bodies (FBs) are not unheard of in the province of surgery. They are commonly seen in men ranging from 20 to 90 years of age with a bimodal age distribution. A variety of objects have been described and reported in literature. Management involves a complete history and examination followed by the necessary investigations. Most of the time they can be removed at bedside with some manipulation techniques employing the use of some ingenious devices and/or endoscopy for adamant objects. But persistent FBs or those that are high in the rectum or those that present with complications will require operative management...
December 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29237288/the-effect-of-continuous-glucose-monitoring-in-preventing-inpatient-hypoglycemia-in-general-wards-the-glucose-telemetry-system
#16
Elias K Spanakis, David L Levitt, Tariq Siddiqui, Lakshmi G Singh, Lillian Pinault, John Sorkin, Guillermo E Umpierrez, Jeffrey C Fink
BACKGROUND: Few studies have examined the use of continuous glucose monitoring (CGM) devices in the general wards. The aim of this pilot study was to examine whether CGM readings can be successfully transmitted from the bedside to a central monitoring device in the nursing station, and whether a glucose telemetry system can prevent hypoglycemic events. METHODS: We present pilot data on 5 consecutive insulin treated general medicine patients with type 2 diabetes (T2DM) whose glucose values were observed with CGM (DEXCOM) and the results were transmitted to a central nursing station monitoring system using DEXCOM Follow and Share 2 software...
December 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29236612/staff-response-times-in-the-epilepsy-monitoring-unit-a-study-of-diurnal-nocturnal-variability
#17
Natalie Witek, Susannah Cornes, Manu Hegde
Although inpatient epilepsy monitoring units (EMUs) are generally safe, seizures in this setting can still produce significant morbidity. The MORTEMUS (MORTality in Epilepsy Monitoring Unit Study) study revealed that the most feared consequence of an unattended seizure-sudden unexpected death in epilepsy (SUDEP)-does occur rarely in the EMU. Nearly all cases identified in that study occurred in the evening. The hypothesis for this study is that unwitnessed seizures would be more likely to occur during the night shift, and that response times to seizures would be slower at night, due to multiple variables...
2017: Neurodiagnostic Journal
https://www.readbyqxmd.com/read/29234998/reduction-of-cardiopulmonary-renal-complications-with-serum-bnp-guided-volume-status-management-in-posthepatectomy-patients
#18
Sameer H Patel, Bradford J Kim, Ching-Wei D Tzeng, Yun Shin Chun, Claudius Conrad, Jean-Nicolas Vauthey, Thomas A Aloia
BACKGROUND: After hepatectomy, over- and under-resuscitations induce cardiopulmonary complications and acute kidney injury, respectively, leading to significant perioperative morbidity and mortality. Unlike serum chemistries or urine output, serum brain natriuretic peptide (BNP) levels have been shown to accurately reflect current intravascular fluid balance without influence from alterations of hormonal axes. Based on these data, this study was designed to measure the impact of a serum BNP-guided hepatobiliary fluid protocol on the incidence of posthepatectomy cardiopulmonary/renal complications...
October 11, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29234277/investigating-the-usability-and-acute-effects-of-a-bedside-video-console-to-prefrontal-cortical-activity-alterations-a-preclinical-study-in-healthy-elderly
#19
Ruud H Knols, Jaap Swanenburg, Dino De Bon, Federico Gennaro, Martin Wolf, Bernard Krüger, Dominique Bettex, Eling D de Bruin
Elderly people at risk of developing cognitive decline; e.g., following surgery, may benefit from structured, challenging, and repetitive cognitive video training. This study assessed usability and acute effects of a newly developed bedside console (COPHYCON). Fifteen healthy elderly individuals performed a one-time 80-min intervention, including cognitive video games aimed at improving awareness and selective attention. Perceived usefulness and perceived ease of use (Technology Acceptance Model) were assessed together with measures of the achieved game level, reaction times, (in-) correct responses during ALERT and SELECT game play...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29233329/bedside-to-bench-and-back-again-surgeon-initiated-translational-research
#20
EDITORIAL
Eric J Charles, Irving L Kron
No abstract text is available yet for this article.
January 2018: Annals of Thoracic Surgery
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