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https://www.readbyqxmd.com/read/28931219/long-term-chikungunya-sequelae-in-cura%C3%A3-ao-burden-determinants-and-a-novel-classification-tool
#1
Jelte Elsinga, Izzy Gerstenbluth, Symkje van der Ploeg, Yaskara Halabi, Norédiz T Lourents, Johannes G Burgerhof, Henry T van der Veen, Ajay Bailey, Martin P Grobusch, Adriana Tami
Background: Beyond the acute illness phase, chikungunya constitutes a public health problem given its chronic disease phase, which may include long-term arthralgia, arthritis, fatigue, and depression. Currently, there is no consensus on how to define chikungunya chronicity. Methods: A comprehensive cross-sectional survey was performed in Curaçao in June and July 2015 to evaluate 304 adult laboratory-confirmed chikungunya patients 3-16 months after diagnosis. We developed a novel tool, the Curaçao Long-Term Chikungunya Sequelae (CLTCS) score, to classify chronic chikungunya disease and estimate its burden regarding disease duration, clinical presentation, and impact on quality of life...
September 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28929893/long-term-health-outcomes-of-childhood-sexual-abuse-and-peer-sexual-contact-among-an-urban-sample-of-behaviourally-bisexual-latino-men
#2
Brian Mattera, Ethan C Levine, Omar Martinez, Miguel Muñoz-Laboy, Carolina Hausmann-Stabile, José Bauermeister, M Isa Fernandez, Don Operario, Carlos Rodriguez-Diaz
While previous research indicates high rates of childhood sexual abuse among Latino men who have sex with men, few studies have examined the long-term health outcomes of childhood sexual abuse specifically among behaviourally bisexual Latino men. In a sample of 148 behaviourally bisexual Latino men in New York City, we examined associations between childhood sexual abuse and multiple dimensions of adult health: sexual risk behaviours; sexually transmitted infections incidence; polydrug use; depressive symptoms; and perceived stress...
September 20, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28928398/bumetanide-treatment-during-early-development-rescues-maternal-separation-induced-susceptibility-to-stress
#3
Die Hu, Zhou-Long Yu, Yan Zhang, Ying Han, Wen Zhang, Lin Lu, Jie Shi
Stress is a major risk factor for psychiatric disorders, such as depression, posttraumatic stress disorder, and schizophrenia. Early life stress, such as maternal separation, can have long-term effects on the development of the central nervous system and pathogenesis of psychiatric disorders. In the present study, we found that maternal separation increased the susceptibility to stress in adolescent rats, increased the expression of Na(+)/K(+)/2Cl(-) cotransporter 1 (NKCC1) on postnatal day 14, and increased the expression of K(+)/2Cl(-) cotransporter 2 (KCC2) and γ-aminobutyric acid A (GABAA) receptor subunits on postnatal day 40 in the hippocampus...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927866/efficacy-of-metacognitive-training-for-patients-with-borderline-personality-disorder-preliminary-results
#4
Lisa Schilling, Steffen Moritz, Levente Kriston, Maria Krieger, Matthias Nagel
'Metacognitive training for borderline personality disorder' (B-MCT) represents a complementary group intervention. It aims at raising awareness for cognitive biases that may play an important role in the development and maintenance of borderline symptomatology. For the present study, we evaluated the effectiveness of this new approach against a control condition. Seventy-four inpatients with borderline personality disorder (BPD) were randomly assigned to metacognitive training for BPD or progressive muscle relaxation training as an add-on intervention to treatment as usual...
September 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28927453/employment-status-and-health-related-quality-of-life-among-hodgkin-lymphoma-survivors-results-based-on-data-from-a-major-treatment-center-in-hungary
#5
Ferenc Magyari, Karolina Kósa, Roland Berecz, Anna Illés, Zsófia Miltényi, Zsófia Simon, Árpád Illés
BACKGROUND: Due to risk and response adapted treatment strategies, more than 80% of newly diagnosed classical Hodgkin lymphoma (HL) patients can be cured, and become long-term survivors. However, a high proportion of survivors suffer from treatment-related long-term side effects such as secondary malignancy, organ failure, persistent fatigue and psychological distress. The aim of this study was to evaluate psychological distress and its risk factors among our HL survivors. METHODS: One hundred sixty-three (50% female) adult HL survivors were contacted between January 1, 2012 and march 31, 2015 in our outpatient centre...
September 19, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28926526/group-interventions-to-reduce-emotional-distress-and-fatigue-in-breast-cancer-patients-a-9-month-follow-up-pragmatic-trial
#6
Charlotte Grégoire, Isabelle Bragard, Guy Jerusalem, Anne-Marie Etienne, Philippe Coucke, Gilles Dupuis, Dominique Lanctôt, Marie-Elisabeth Faymonville
BACKGROUND: Long-term effects of psychosocial interventions to reduce emotional distress, sleep difficulties, and fatigue of breast cancer patients are rarely examined. We aim to assess the effectiveness of three group interventions, based on cognitive behavioural therapy (CBT), yoga, and self-hypnosis, in comparison to a control group at a 9-month follow-up. METHODS: A total of 123 patients chose to participate in one of the interventions. A control group was set up for those who agreed not to participate...
September 19, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28926076/electronic-imitation-of-behavioral-and-psychological-synaptic-activities-using-tiox-al2o3-based-memristor-devices
#7
Writam Banerjee, Qi Liu, Hangbing Lv, Shibing Long, Ming Liu
Seeking an effective electronic synapse to emulate biological synaptic behavior is fundamental for building brain-inspired computers. An emerging two-terminal memristor, in which the conductance can be gradually modulated by external electrical stimuli, is widely considered as the strongest competitor of the electronic synapse. Here, we show the capability of TiOx/Al2O3-based memristor devices to imitate synaptic behaviors. Along with analog resistive switching performances, the devices replicate the bio-synapse behaviors of potentiation/depression, short-term-plasticity, and long-term-potentiation, which show that TiOx/Al2O3-based memristors may be useful as electronic synapses...
September 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28926003/age-of-first-exposure-to-american-football-and-long-term-neuropsychiatric-and-cognitive-outcomes
#8
M L Alosco, A B Kasimis, J M Stamm, A S Chua, C M Baugh, D H Daneshvar, C A Robbins, M Mariani, J Hayden, S Conneely, R Au, A Torres, M D McClean, A C McKee, R C Cantu, J Mez, C J Nowinski, B M Martin, C E Chaisson, Y Tripodis, R A Stern
Previous research suggests that age of first exposure (AFE) to football before age 12 may have long-term clinical implications; however, this relationship has only been examined in small samples of former professional football players. We examined the association between AFE to football and behavior, mood and cognition in a large cohort of former amateur and professional football players. The sample included 214 former football players without other contact sport history. Participants completed the Brief Test of Adult Cognition by Telephone (BTACT), and self-reported measures of executive function and behavioral regulation (Behavior Rating Inventory of Executive Function-Adult Version Metacognition Index (MI), Behavioral Regulation Index (BRI)), depression (Center for Epidemiologic Studies Depression Scale (CES-D)) and apathy (Apathy Evaluation Scale (AES))...
September 19, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28926001/ketamine-differential-neurophysiological-dynamics-in-functional-networks-in-the-rat-brain
#9
A Ahnaou, H Huysmans, R Biermans, N V Manyakov, W H I M Drinkenburg
Recently, the N-methyl-d-aspartate-receptor (NMDAR) antagonist ketamine has emerged as a fast-onset mechanism to achieve antidepressant activity, whereas its psychomimetic, dissociative and amnestic effects have been well documented to pharmacologically model schizophrenia features in rodents. Sleep-wake architecture, neuronal oscillations and network connectivity are key mechanisms supporting brain plasticity and cognition, which are disrupted in mood disorders such as depression and schizophrenia. In rats, we investigated the dynamic effects of acute and chronic subcutaneous administration of ketamine (2...
September 19, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28925498/electronic-diary-for-recording-headaches-triggers-and-medication-use-development-and-evaluation
#10
Siavash Bandarian-Balooch, Paul R Martin, Brenton McNally, Arissa Brunelli, Sharon Mackenzie
OBJECTIVE: To evaluate an e-diary developed for measuring headaches, triggers, and medication consumption, in terms of reliability and validity, and variables such as ease of use and participant compliance. BACKGROUND: For many decades, behavioral treatment of headaches has been evaluated via participants completing paper diaries recording their headaches and associated phenomena. There is some limited evidence supporting the reliability and validity of paper diaries, and criticisms have been offered such as the large amount of effort involved for both participants and researchers...
September 19, 2017: Headache
https://www.readbyqxmd.com/read/28923760/commonly-used-patient-reported-outcomes-do-not-improve-prediction-of-copd-exacerbations-a-multicenter-4-5-year-prospective-cohort-study
#11
Alexandra Strassmann, Anja Frei, Sarah R Haile, Gerben Ter Riet, Milo A Puhan
BACKGROUND: Several cross-sectional and short-term studies suggest that patient-reported outcomes (PROs) may be useful to (help) predict COPD exacerbations but evidence from long-term prospective cohort studies is missing. Our aim was to assess if PROs add to the prediction of exacerbations. METHODS: 408 primary care COPD patients participated in the multicenter prospective ICE COLD ERIC cohort. PROs included the Chronic Respiratory Disease Questionnaire, the Hospital Anxiety and Depression Scale, the Feeling Thermometer and the LASA Physical Activity Questionnaire (LAPAQ)...
September 15, 2017: Chest
https://www.readbyqxmd.com/read/28922050/how-to-interpret-high-levels-of-distress-when-using-the-distress-thermometer-in-the-long-term-follow-up-clinic-a-study-with-acute-lymphoblastic-leukemia-survivors
#12
A J Pépin, S Lippé, M Krajinovic, C Laverdière, B Michon, D Sinnett, S Sultan
OBJECTIVES: Recent guidelines recommend to assess emotional distress in pediatric oncology during treatment and in after care. One tool used to do this is the distress thermometer (DT), a simple tool which has almost exclusively been studied in its screening abilities. Given its increased used as a measure of distress per se, it is necessary to document its concurrent validity. The goal of this study was to identify clinical domains (eg, depression, anxiety) and individual symptoms associated with pediatric cancer survivors' rating on the DT...
September 18, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/28921757/the-neurobiological-bases-of-autism-spectrum-disorders-the-r451c-neuroligin-3-mutation-hampers-the-expression-of-long-term-synaptic-depression-in-the-dorsal-striatum
#13
Giuseppina Martella, Maria Meringolo, Laura Trobiani, Antonella De Jaco, Antonio Pisani, Paola Bonsi
Autism spectrum disorders (ASDs) comprise a heterogeneous group of disorders with a complex genetic etiology. Current theories on the pathogenesis of ASDs suggest that they might arise from an aberrant synaptic transmission affecting specific brain circuits and synapses. The striatum, which is part of the basal ganglia circuit, is one of the brain regions involved in ASDs. Mouse models of ASDs have provided evidence for an imbalance between excitatory and inhibitory neurotransmission. Here we investigated the expression of long-term synaptic plasticity at corticostriatal glutamatergic synapses in the dorsal striatum of the R451C-NL3 phenotypic mouse model of autism...
September 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28918440/interpersonal-sensitivity-and-persistent-attenuated-psychotic-symptoms-in-adolescence
#14
Alice Masillo, M Brandizzi, L R Valmaggia, R Saba, N Lo Cascio, J F Lindau, L Telesforo, P Venturini, D Montanaro, D Di Pietro, M D'Alema, P Girardi, P Fiori Nastro
Interpersonal sensitivity defines feelings of inner-fragility in the presence of others due to the expectation of criticism or rejection. Interpersonal sensitivity was found to be related to attenuated positive psychotic symptom during the prodromal phase of psychosis. The aims of this study were to examine if high level of interpersonal sensitivity at baseline are associated with the persistence of attenuated positive psychotic symptoms and general psychopathology at 18-month follow-up. A sample of 85 help-seeking individuals (mean age = 16...
September 16, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28916897/improvement-of-quality-of-life-and-psychological-distress-after-inpatient-cancer-rehabilitation-results-of-a%C3%A2-longitudinal-observational-study
#15
David Riedl, Johannes M Giesinger, Lisa M Wintner, Fanny L Loth, Gerhard Rumpold, Richard Greil, Alain Nickels, Thomas Licht, Bernhard Holzner
BACKGROUND: With the growing number of cancer survivors worldwide the need for high quality cancer rehabilitation after primary treatment is steadily increasing. The aim of the present study was to investigate change of psychological distress and health-related quality of life (HRQOL) during multidisciplinary inpatient cancer rehabilitation in a large sample of cancer survivors suffering from different cancer entities. METHODS: We analyzed data from routine HRQOL and distress monitoring at a cancer inpatient rehabilitation center...
September 15, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28916506/blending-face-to-face-and-internet-based-interventions-for-the-treatment-of-mental-disorders-in-adults-systematic-review
#16
Doris Erbe, Hans-Christoph Eichert, Heleen Riper, David Daniel Ebert
BACKGROUND: Many studies have provided evidence for the effectiveness of Internet-based stand-alone interventions for mental disorders. A newer form of intervention combines the strengths of face-to-face (f2f) and Internet approaches (blended interventions). OBJECTIVE: The aim of this review was to provide an overview of (1) the different formats of blended treatments for adults, (2) the stage of treatment in which these are applied, (3) their objective in combining face-to-face and Internet-based approaches, and (4) their effectiveness...
September 15, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28916502/sociability-trait-and-regional-cerebral-oxidative-metabolism-in-rats-predominantly-nonlinear-relations
#17
Margus Kanarik, Jaanus Harro
Deficits in social behaviour are common in psychopathological conditions e.g., depression, autism and schizophrenia. In rats, sociability, defined as the engagement of an animal in non-aggressive social contact with a conspecific in a neutral arena, is as a persistent trait. To elucidate the neuroanatomy of social behaviour in animal models, long term neuronal energy metabolism was studied in rats preselected for sociability levels. Rats were divided into groups with high, medium and low sociability levels (HS, MS and LS) according to the average score of three social interaction tests, and cerebral long-term energy metabolism was assayed with cytochrome oxidase histochemistry...
September 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28916046/inflammatory-response-and-long-term-behavioral-assessment-after-neonatal-co2-pneumothorax-study-in-a-rodent-model
#18
Alice Miranda, Susana Roque, Cláudia Serre-Miranda, José Miguel Pêgo, Jorge Correia-Pinto
BACKGROUND: Carbon-dioxide (CO2)-pneumothorax during minimally invasive surgery induces well-known metabolic changes. However, little is known about its impact on the central nervous system. The aim of this work is to evaluate the acute impact of CO2-pneumothorax over central cytokine response and its long-term effect on animal behavior. METHODS: This is an experimental study where neonatal Sprague-Dawley rats are submitted to CO2-pneumothorax. Peripheral and central cytokine response was evaluated 24h after insufflation, and peripheral immune cell phenotyping was evaluated 24h and 4weeks post-insufflation...
August 24, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28915242/a-retrospective-cost-analysis-of-additional-homeopathic-treatment-in-germany-long-term-economic-outcomes
#19
Julia K Ostermann, Claudia M Witt, Thomas Reinhold
OBJECTIVES: This study aimed to provide a long-term cost comparison of patients using additional homeopathic treatment (homeopathy group) with patients using usual care (control group) over an observation period of 33 months. METHODS: Health claims data from a large statutory health insurance company were analysed from both the societal perspective (primary outcome) and from the statutory health insurance perspective (secondary outcome). To compare costs between patient groups, homeopathy and control patients were matched in a 1:1 ratio using propensity scores...
2017: PloS One
https://www.readbyqxmd.com/read/28913486/the-switch-from-buprenorphine-to-tapentadol-is-it-worth
#20
REVIEW
Adriana Miclescu
Opioid analgesia continues to be the primary pharmacologic intervention for managing acute pain and malignant pain in both hospitalized and ambulatory patients. The increasing use of opioids in chronic nonmalignant pain is more problematic. Opioid treatment is complicated with the risks raised by adverse effects, especially cognitive disturbance, respiratory depression but also the risk of tolerance, opioid abuse and drug-disease interactions. Despite the growing number of available opioids within the last years, adequate trials of opioid rotation are lacking and most of the information is anecdotal...
October 2016: Rom J Anaesth Intensive Care
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