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Long term depression

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https://www.readbyqxmd.com/read/29792234/long-term-outcomes-of-acute-treatment-with-cognitive-therapy-v-interpersonal-psychotherapy-for-adult-depression-follow-up-of-a-randomized-controlled-trial
#1
Lotte H J M Lemmens, Suzanne C van Bronswijk, Frenk Peeters, Arnoud Arntz, Steven D Hollon, Marcus J H Huibers
BACKGROUND: Although equally efficacious in the acute phase, it is not known how cognitive therapy (CT) and interpersonal psychotherapy (IPT) for major depressive disorder (MDD) compare in the long run. This study examined the long-term outcomes of CT v. IPT for MDD. METHODS: One hundred thirty-four adult (18-65) depressed outpatients who were treated with CT (n = 69) or IPT (n = 65) in a large open-label randomized controlled trial (parallel group design; computer-generated block randomization) were monitored across a 17-month follow-up phase...
May 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29792226/treatment-of-depression-and-or-anxiety-outcomes-of-a-randomised-controlled-trial-of-the-tree-theme-method%C3%A2-versus-regular-occupational-therapy
#2
A Birgitta Gunnarsson, Petra Wagman, Katarina Hedin, Carita Håkansson
BACKGROUND: Depression and anxiety disorders are a major concern in western countries, and because these often have a negative affect on everyday life interventions based on activities in everyday life are needed. The Tree Theme Method® (TTM) is a client-centred occupational therapy intervention designed to increase the ability to cope with, and to enhance satisfaction with, everyday life, both at home and at work. The aim of this study was to compare the short term outcomes of the TTM intervention with regular occupational therapy treatment for people with depression and/or anxiety disorders...
May 23, 2018: BMC Psychology
https://www.readbyqxmd.com/read/29792195/histamine-activates-inflammatory-response-and-depresses-casein-synthesis-in-mammary-gland-of-dairy-cows-during-sara
#3
Guangjun Chang, Lailai Wang, Nana Ma, Wenwen Zhang, Huanmin Zhang, Hongyu Dai, Xiangzhen Shen
BACKGROUND: Mounting evidences observed that subacute ruminal acidosis (SARA) induced by high concentration (HC) diet increases the translocation of histamine from digestive tract into circulation causing a diverse of diseases in dairy cows. However, it is largely unknown how it does affect the function of mammary gland and milk quality. Hence, this study aims to observe the effects of histamine derived from the digestive tract on the inflammatory response and casein synthesis in the mammary glands during SARA...
May 23, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29790931/gsk3%C3%AE-modulates-timing-dependent-long-term-depression-through-direct-phosphorylation-of-kv4-2-channels
#4
Giuseppe Aceto, Agnese Re, Andrea Mattera, Lucia Leone, Claudia Colussi, Marco Rinaudo, Federico Scala, Katia Gironi, Saviana Antonella Barbati, Salvatore Fusco, Thomas Green, Fernanda Laezza, Marcello D'Ascenzo, Claudio Grassi
Spike timing-dependent plasticity (STDP) is a form of activity-dependent remodeling of synaptic strength that underlies memory formation. Despite its key role in dictating learning rules in the brain circuits, the molecular mechanisms mediating STDP are still poorly understood. Here, we show that spike timing-dependent long-term depression (tLTD) and A-type K+ currents are modulated by pharmacological agents affecting the levels of active glycogen-synthase kinase 3 (GSK3) and by GSK3β knockdown in layer 2/3 of the mouse somatosensory cortex...
February 23, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29789774/pilot-study-of-dose-response-effects-of-exercise-on-change-in-c-reactive-protein-cortisol-and-health-related-quality-of-life-among-cancer-survivors
#5
Jeanette M Ricci, Victoria Flores, Isabela Kuroyama, Arash Asher, Heather P Tarleton
Fatigue, stress, and depression contribute to poor health-related quality of life (HRQoL) among cancer survivors. This study examined the effects of combined aerobic and resistance training (CART) on HRQoL and biomarkers of stress. Cancer survivors ( n  = 76, 91% female, 39% breast cancer, 32% gynecologic cancer) were enrolled in CART for three 60-min sessions, weekly, for 26 weeks. Participants completed the National Institutes of Health's Patient Reported Outcomes Measurement Information System (NIH PROMIS) fatigue assessment and the SF-36...
2018: BioResearch Open Access
https://www.readbyqxmd.com/read/29788381/the-role-of-apathy-and-depression-on-verbal-learning-and-memory-performance-after-stroke
#6
Keera N Fishman, Andrea R Ashbaugh, Krista L Lanctôt, Megan L Cayley, Nathan Herrmann, Brian J Murray, Michelle Sicard, Karen Lien, Demetrios J Sahlas, Richard H Swartz
Objective: Psychiatric symptoms, including depression and apathy, may significantly impede functional and cognitive capabilities following a cerebrovascular event. This study examined the role of apathy and depression on learning and memory performance in stroke patients. Method: Stroke patients (n = 140 [119 ischemic, 21 hemorrhagic], mean age = 60.6 [SD = 15.1]) completed the Apathy Evaluation Scale (AES), the Center for Epidemiologic Studies Depression Scale (CES-D), and the California Verbal Learning Test-Second Edition (CVLT-II)...
May 18, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29786082/mtorc2-but-not-mtorc1-is-required-for-hippocampal-mglur-ltd-and-associated-behaviors
#7
Ping Jun Zhu, Chien-Ju Chen, Jacqunae Mays, Loredana Stoica, Mauro Costa-Mattioli
The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD and associated behaviors. Moreover, rapamycin blocks mGluR-LTD in mTORC1-deficient mice. However, both rapamycin and mGluR activation regulate mTOR complex 2 (mTORC2) activity, and mTORC2-deficient mice show impaired mGluR-LTD and associated behaviors. Thus, mTORC2 is a major regulator of mGluR-LTD...
May 21, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29785803/depressive-spectrum-states-in-a-population-based-cohort-of-70-year-olds-followed-over-9-years
#8
Robert Sigström, Margda Waern, Pia Gudmundsson, Ingmar Skoog, Svante Östling
OBJECTIVE: Depression may be understood as a spectrum of more or less symptomatic states. Little is known about the long-term course of these states in older populations. We examined the prevalence and course of depressive states of different severity in a Swedish population sample of older people followed over 9 years. METHODS: A population-based sample of 70-year olds without dementia (N = 563, response rate 71.1%) underwent a psychiatric examination; 450 survivors without dementia were reexamined at ages 75 and/or 79 years...
May 21, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29784233/using-baseline-data-to-predict-chronic-ptsd-48-months-after-mothers-report-intimate-partner-violence-outcomes-for-mothers-and-the-intergenerational-impact-on-child-behavioral-functioning
#9
John Maddoux, Judith McFarlane, Lene Symes, Nina Fredland, Gene Feder
Worldwide one in three women report intimate partner violence. Many of these women report long term mental health problems, especially PTSD, which is associated with negative problem solving, isolation, somatization, depression, and anxiety. Children are impacted by their exposure to domestic violence and experience internal (i.e., depression, anxiety) and external (i.e., hostility, delinquency) behavioral clinical problems. To predict which women will experience chronic PTSD symptoms, a PTSD predictor tool was developed and applied to PTSD symptom scores four years after 300 mothers with children (age 18 months to 16 years) received assistance for the violence...
June 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29784116/gendered-mechanisms-underlie-the-relation-between-pubertal-timing-and-adult-depressive-symptoms
#10
Adriene M Beltz
PURPOSE: Sex differences in depression emerge in adolescence, in concert with puberty. Off-time maturers, especially early-maturing girls, report more depressive symptoms than their same-sex peers. Recent evidence shows that these pubertal timing effects persist into adulthood, but the underlying mechanisms are unclear. METHODS: Participants were 318 young adults (201 women, 117 men) who rated their depressive symptoms in the past 2 weeks and provided valid retrospective reports of their pubertal timing...
June 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29783936/identifying-and-assessing-the-benefits-of-interventions-for-postnatal-depression-a-systematic-review-of-economic-evaluations
#11
Binu Gurung, Louise J Jackson, Mark Monahan, Ruth Butterworth, Tracy E Roberts
BACKGROUND: Economic evaluations of interventions for postnatal depression (PND) are essential to ensure optimal healthcare decision-making. Due to the wide-ranging effects of PND on the mother, baby and whole family, there is a need to include outcomes for all those affected and to include health and non-health outcomes for accurate estimates of cost-effectiveness. This study aimed to identify interventions to prevent or treat PND for which an economic evaluation had been conducted and to evaluate the health and non-health outcomes included...
May 21, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29782505/are-pension-types-associated-with-happiness-in-japanese-older-people-jages-cross-sectional-study
#12
Ichiro Sasaki, Katsunori Kondo, Naoki Kondo, Jun Aida, Hiroshi Ichikawa, Takashi Kusumi, Naoya Sueishi, Yuichi Imanaka
BACKGROUND: Although many previous studies have examined the determinants of happiness in older adults, few have investigated the association between pension types and happiness. When compared to other conventional socioeconomic indicators, pension types may be more indicative of long-term socioeconomic status as they can reflect a person's job history over their life course. This study examined the association between pension types and happiness in Japanese older people. METHODS: Cross-sectional survey data from the Japan Gerontological Evaluation Study were used to analyze the association between pension types and happiness...
2018: PloS One
https://www.readbyqxmd.com/read/29781651/exposure-and-cbt-for-chronic-back-pain-an-rct-on-differential-efficacy-and-optimal-length-of-treatment
#13
Julia Anna Glombiewski, Sebastian Holzapfel, Jenny Riecke, Johan W S Vlaeyen, Jeroen de Jong, Gunnar Lemmer, Winfried Rief
OBJECTIVE: Our aim was to establish whether Exposure, a specialized tailored treatment for chronic low back pain, has any advantages over cognitive-behavioral therapy (CBT) among individuals with high fear-avoidance levels. Second, we planned to compare short and long versions of Exposure. Third, we aimed to investigate whether Exposure can be delivered in an outpatient psychological setting. METHOD: A total of 88 Caucasian participants (55% women) were randomized to three different psychological treatment conditions, Exposure-long, Exposure-short, and CBT...
June 2018: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29781504/epidural-versus-non-epidural-or-no-analgesia-for-pain-management-in-labour
#14
REVIEW
Millicent Anim-Somuah, Rebecca Md Smyth, Allan M Cyna, Anna Cuthbert
BACKGROUND: Epidural analgesia is a central nerve block technique achieved by injection of a local anaesthetic close to the nerves that transmit pain, and is widely used as a form of pain relief in labour. However, there are concerns about unintended adverse effects on the mother and infant. This is an update of an existing Cochrane Review (Epidural versus non-epidural or no analgesia in labour), last published in 2011. OBJECTIVES: To assess the effectiveness and safety of all types of epidural analgesia, including combined-spinal-epidural (CSE) on the mother and the baby, when compared with non-epidural or no pain relief during labour...
May 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29780310/mobile-software-as-a-medical-device-samd-for-the-treatment-of-epilepsy-development-of-digital-therapeutics-comprising-behavioral-and-music-based-interventions-for-neurological-disorders
#15
Pegah Afra, Carol S Bruggers, Matthew Sweney, Lilly Fagatele, Fareeha Alavi, Michael Greenwald, Merodean Huntsman, Khanhly Nguyen, Jeremiah K Jones, David Shantz, Grzegorz Bulaj
Digital health technologies for people with epilepsy (PWE) include internet-based resources and mobile apps for seizure management. Since non-pharmacological interventions, such as listening to specific Mozart's compositions, cognitive therapy, psychosocial and educational interventions were shown to reduce epileptic seizures, these modalities can be integrated into mobile software and delivered by mobile medical apps as digital therapeutics. Herein, we describe: (1) a survey study among PWE about preferences to use mobile software for seizure control, (2) a rationale for developing digital therapies for epilepsy, (3) creation of proof-of-concept mobile software intended for use as an adjunct digital therapeutic to reduce seizures, and (4) broader applications of digital therapeutics for the treatment of epilepsy and other chronic disorders...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29779233/long-term-high-intensity-sound-stimulation-inhibits-h-current-i-h-in-ca1-pyramidal-neurons
#16
A O S Cunha, C C Ceballos, J L de Deus, R M Leão
Afferent neurotransmission to hippocampal pyramidal cells can lead to long-term changes to their intrinsic membrane properties and affect many ion currents. One of the most plastic neuronal currents is the hyperpolarization activated cationic current (Ih ), which changes in CA1 pyramidal cells in response to many types of physiological and pathological processes, including auditory stimulation. Recently we demonstrated that long-term potentiation (LTP) in rat hippocampal Schaffer-CA1 synapses is depressed by high-intensity sound stimulation...
May 19, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29778459/bisphenol-a-inhibits-improvement-of-testosterone-in-anxiety-and-depression-like-behaviors-in-gonadectomied-male-mice
#17
Yvfeng Liang, Jiahong Li, Tao Jin, Ting Gu, Qingjie Zhu, Yizhong Hu, Yang Yang, Jisui Li, Donghong Wu, Kesheng Jiang, Xiaohong Xu
Bisphenol-A (BPA) is a well-known environmental endocrine disruptor. Developmental exposure to BPA affected a variety of behaviors in multiple model organisms. Our recent study found that exposure to BPA during adulthood aggravated anxiety- and depression-like states in male mice but not in females. In this study, 11-w-old gonadectomied (GDX) male mice daily received subcutaneous injections of testosterone propionate (TP, 0.5 mg/kg), TP and BPA (0.04, 0.4, or 4 mg/kg), or vehicle for 45 days. BPA (0.4 or 4 mg/kg) did not affect the elevated plus maze task of GDX mice but shortened the time on open arms and decreased the frequency of head dips of sham and TP-GDX mice...
May 17, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29778254/long-term-liver-disease-treatment-and-mortality-outcomes-among-17-000-persons-diagnosed-with-chronic-hepatitis-c-virus-infection-current-chronic-hepatitis-cohort-study-status-and-review-of-findings
#18
REVIEW
Anne C Moorman, Loralee B Rupp, Stuart C Gordon, Yuna Zhong, Jian Xing, Mei Lu, Joseph A Boscarino, Mark A Schmidt, Yihe G Daida, Eyasu H Teshale, Philip R Spradling, Scott D Holmberg
Chronic Hepatitis Cohort Study (CHeCS) publications using data from "real-world" patients with hepatitis C virus (HCV) have described demographic disparities in access to care; rates of advanced liver disease, morbidity, and mortality (2.5%-3.5% per year during 2006-10, although only 19% of all CHeCS decedents, and just 30% of those with deaths attributed to liver disease, had HCV listed on death certificate); substantial comorbidities, such as diabetes, advanced liver fibrosis (29% prevalence), renal disease, and depression, and partial reversal of all these with successful antiviral therapy; patient risk behaviors; and use of noninvasive markers to assess liver disease...
June 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29778251/the-impact-of-group-based-tai-chi-on-health-status-outcomes-among-community-dwelling-older-adults-with-hypertension
#19
Chunhua Ma, Wei Zhou, Qiubo Tang, Shuling Huang
OBJECTIVES: To test the effects of group-based Tai chi on health-status outcomes among older adults with hypertension. BACKGROUND: A high-quality study exploring the effects of Tai chi on physical and psychosocial health for older adults with hypertension is needed in China. The long-term effects of group-based Tai chi in Chinese older adults with hypertension remain unclear. METHODS: A randomized controlled trial was conducted. The group-based Tai chi training and practice were implemented in older adults over six-month...
May 16, 2018: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/29775876/childhood-abuse-and-depression-in-adulthood-the-mediating-role-of-allostatic-load
#20
Sandra Scheuer, Nicole Wiggert, Tanja Maria Brückl, Yvonne Awaloff, Manfred Uhr, Susanne Lucae, Stefan Kloiber, Florian Holsboer, Marcus Ising, Frank H Wilhelm
BACKGROUND: Traumatic experiences during childhood are considered a major risk factor for depression in adulthood. Childhood trauma may induce physiological dysregulation with long-term effects of increased allostatic load until adulthood, which may lead to depression. Thus, our aim was to investigate whether allostatic load - which represents a multi-system measure of physiological dysregulation - mediates the association between childhood trauma and adult depression. METHODS: The study sample consisted of 324 depressed inpatients participating in the Munich Antidepressant Response Signature (MARS) project and 261 mentally healthy control participants...
April 22, 2018: Psychoneuroendocrinology
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