keyword
https://read.qxmd.com/read/38517820/effect-of-orthodontics-combined-with-fibre-reinforced-composite-resin-bonded-fixed-partial-denture-on-anterior-dentition-defects-with-minimal-vertical-intermaxillary-space
#1
JOURNAL ARTICLE
Shi-Lei Han, Na Li
BACKGROUND: Prosthodontics are often performed to treat patients with malocclusion and dentition defects. However, single prosthodontics cannot properly correct the disharmony of teeth, dental arch and other parts affected by malocclusion, and some patients may have difficulty in recovering the occlusal function due to poor prosthodontics. OBJECTIVE: This study aims to investigate the effect of orthodontics combined with fibre-reinforced composite resin-bonded fixed partial denture (FRC-RBFPD) on anterior dentition defects with minimal vertical intermaxillary space...
February 29, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://read.qxmd.com/read/37286175/the-microglial-innate-immune-receptors-trem-1-and-trem-2-in-the-anterior-cingulate-cortex-acc-drive-visceral-hypersensitivity-and-depressive-like-behaviors-following-dss-induced-colitis
#2
JOURNAL ARTICLE
Ke Wu, Yue-Ying Liu, Shuai Shao, Wei Song, Xing-Han Chen, Yu-Ting Dong, Yong-Mei Zhang
Inflammatory bowel disease (IBD) is a chronic condition with a high recurrence rate. To date, the clinical treatment of IBD mainly focuses on inflammation and gastrointestinal symptoms while ignoring the accompanying visceral pain, anxiety, depression, and other emotional symptoms. Evidence is accumulating that bi-directional communication between the gut and the brain is indispensable in the pathophysiology of IBD and its comorbidities. Increasing efforts have been focused on elucidating the central immune mechanisms in visceral hypersensitivity and depression following colitis...
June 5, 2023: Brain, Behavior, and Immunity
https://read.qxmd.com/read/31568781/nalbuphine-a-kappa-opioid-receptor-agonist-and-mu-opioid-receptor-antagonist-attenuates-pruritus-decreases-il-31-and-increases-il-10-in-mice-with-contact-dermatitis
#3
JOURNAL ARTICLE
Saadet Inan, Alvaro T Huerta, Liselotte E Jensen, Nae J Dun, Alan Cowan
Chronic itch is one of the disturbing symptoms of inflammatory skin diseases. Kappa opioid receptor agonists are effective in suppressing scratching in mice against different pruritogens. Nalbuphine, a nonscheduled kappa opioid receptor agonist and mu opioid receptor antagonist, has been in clinical use for post-operative pain management since the 1980s and recently has been in clinical trials for chronic itch of prurigo nodularis (https://www.trevitherapeutics.com/nalbuphine). We studied whether nalbuphine is effective against chronic scratching induced by rostral neck application of 1-fluoro-2,4-dinitrobenzene (DNFB), an accepted mouse model of contact dermatitis to study pruritoceptive itch...
September 27, 2019: European Journal of Pharmacology
https://read.qxmd.com/read/31488032/effect-of-dehydrocostus-lactone-isolated-from-the-roots-of-aucklandia-lappa-on-the-apoptosis-of-endometriotic-cells-and-the-alternative-activation-of-endometriosis-associated-macrophages
#4
JOURNAL ARTICLE
Jeong-Hwa Woo, Ji-Hye Ahn, Dae Sik Jang, Jung-Hye Choi
The roots of Aucklandia lappa have been used in traditional medicine in Asia to treat inflammation and diseases associated with pain, including endometriosis. The aim of this study was to investigate the anti-endometriotic effect of dehydrocostus lactone, an active compound in A. lappa roots, using human endometriotic cells and macrophages stimulated by these cells. Dehydrocostus lactone induced apoptotic cell death in 12Z human endometriotic cells. Dehydrocostus lactone stimulated the activation of caspase-3, -8, and -9, while caspase inhibitors significantly reversed the dehydrocostus lactone-induced cell death in 12Z cells...
September 5, 2019: American Journal of Chinese Medicine
https://read.qxmd.com/read/30551457/inhibition-of-trem1-reduces-inflammation-and-oxidative-stress-after-spinal-cord-injury-sci-associated-with-ho-1-expressions
#5
JOURNAL ARTICLE
Zhenhuan Li, Furong Wu, Dafeng Xu, Zhongzheng Zhi, Guanghui Xu
Spinal cord injury (SCI) is a devastating event, leading to the progression of chronic neuropathic pain syndrome. Triggering receptor expressed on myeloid cells 1 (TREM1) is an innate immune receptor expressed on neutrophils and monocytes/macrophages. TREM1 enhances inflammatory response in various models of diseases, but its significance in SCI remains unclear. In the present study, we attempted to explore the effects of TREM1 on the regulation of SCI. Spinal cord contusion injury was performed in wild type (WT) and TREM1-knockout (TREM1KO ) mice, and real time-quantitative PCR (RT-qPCR), western blot, and immunofluorescent (IF) staining were used to calculate TREM1, inflammation and oxidative stress in spinal cord tissues 42 days after SPII...
January 2019: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/29516326/assessment-of-serum-strem-1-as-a-marker-of-subclinical-inflammation-in-diarrhea-predominant-patients-with-irritable-bowel-syndrome
#6
JOURNAL ARTICLE
Chao Du, Lijun Peng, Guanjun Kou, Peng Wang, Lin Lu, Yanqing Li
BACKGROUND: Irritable bowel disease (IBS) is viewed upon as a functional disorder of subclinical inflammatory changes in recent years, and there is no reliable biomarker. Triggering receptor expressed on myeloid cells 1 (TREM-1), also produced in a soluble form (sTREM-1), is involved in the activation of inflammatory cascades of intracellular events and may play a role in pathogenesis of IBS. AIM: To investigate whether serum sTREM-1 level can be used as a marker of subclinical inflammation in D-IBS...
May 2018: Digestive Diseases and Sciences
https://read.qxmd.com/read/29382241/is-standing-balance-altered-in-individuals-with-chronic-low-back-pain-a-systematic-review
#7
JOURNAL ARTICLE
Yevgeniy Berenshteyn, Kelsey Gibson, Gavin C Hackett, Andrew B Trem, Mark Wilhelm
PURPOSE: To examine the static standing balance of individuals with chronic low back pain when compared to a healthy control group. METHODS: A search of available literature was done using PubMed, SPORTDiscus, CINAHL, and Scopus databases. Studies were included if they contained the following: (1) individuals with chronic low back pain 3 months or longer; (2) healthy control group; (3) quantified pain measurement; and (4) center of pressure measurement using a force plate...
January 30, 2018: Disability and Rehabilitation
https://read.qxmd.com/read/29051087/triggering-receptor-expressed-on-myeloid-cells-2-trem2-dependent-microglial-activation-promotes-cisplatin-induced-peripheral-neuropathy-in-mice
#8
JOURNAL ARTICLE
Lang-Yue Hu, Yang Zhou, Wen-Qiang Cui, Xue-Ming Hu, Li-Xia Du, Wen-Li Mi, Yu-Xia Chu, Gen-Cheng Wu, Yan-Qing Wang, Qi-Liang Mao-Ying
Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse side effect of many antineoplastic agents. Patients treated with chemotherapy often report pain and paresthesias in a "glove-and-stocking" distribution. Diverse mechanisms contribute to the development and maintenance of CIPN. However, the role of spinal microglia in CIPN is not completely understood. In this study, cisplatin-treated mice displayed persistent mechanical allodynia, sensory deficits and decreased density of intraepidermal nerve fibers (IENFs)...
February 2018: Brain, Behavior, and Immunity
https://read.qxmd.com/read/27792788/trem-1-hmgb1-and-rage-in-the-shoulder-tendon-dual-mechanisms-for-inflammation-based-on-the-coincidence-of-glenohumeral-arthritis
#9
JOURNAL ARTICLE
Finosh G Thankam, Matthew F Dilisio, Nicholas E Dietz, Devendra K Agrawal
Rotator cuff injury (RCI) is a major musculoskeletal disorder in the adult population where inflammation and pain are major contributing factors. Coincidence of other clinical conditions like glenohumeral arthritis aggravates inflammation and delays the healing response. The mechanism and signaling factors underlying the sustenance of inflammation in the rotator cuff joint are largely unknown. The present article aims to elucidate the involvement of inflammatory molecule, TREM-1 (Triggering Receptors Expressed on Myeloid cells-1), and danger-associated molecular patterns (DAMPs), including high mobility group protein 1 (HMGB-1) and RAGE (receptor for advanced glycation end products), in the setting of RCI with respect to the severity of glenohumeral arthritis...
2016: PloS One
https://read.qxmd.com/read/25147325/levels-of-soluble-trem-like-transcript-1-in-patients-presenting-to-the-emergency-department-with-chest-pain
#10
JOURNAL ARTICLE
Omar L Esponda, Robert Hunter, José R Rivera Del Río, A Valance Washington
OBJECTIVE: Recent studies suggest that the soluble triggering receptor expressed on myeloid cells-like transcript 1 (sTLT-1) facilitate atherothrombosis. Therefore, we evaluated sTLT-1 as a functional measure of atherothrombosis in acute coronary syndrome (ACS). METHODS: Levels of sTLT-1 were determined by enzyme-linked immunosorbent assay on plasma from patients with potential ACS and compared with an age-matched control group with similar risk factors for cardiovascular disease...
January 2015: Clinical and Applied Thrombosis/hemostasis
https://read.qxmd.com/read/21114709/triggering-receptor-trem-1-expressed-on-myeloid-cells-predicts-bacteremia-better-than-clinical-variables-in-community-acquired-pneumonia
#11
JOURNAL ARTICLE
Agustin Ruiz-González, Aureli Esquerda, Miquel Falguera, Nadia Abdulghani, Pamela Cabezas, Silvia Bielsa, José M Porcel
BACKGROUND AND OBJECTIVE: Some clinical variables are associated with bacteremia in patients with community-acquired pneumonia (CAP). The aim of this study was to analyse the accuracy of the soluble form of triggering receptor expressed on myeloid cells-1 (sTREM-1) to predict positive blood cultures in comparison with established clinical prognostic variables. METHODS: In addition to collecting clinical and laboratory information, a commercially available immunoassay kit was used to measure the serum sTREM-1 levels on the first day of admit ion in patients with CAP...
February 2011: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://read.qxmd.com/read/18821074/how-can-calcium-pyrophosphate-crystals-induce-inflammation-in-hypophosphatasia-or-chronic-inflammatory-joint-diseases
#12
REVIEW
C Beck, H Morbach, P Richl, M Stenzel, H J Girschick
Hypophosphatasia (HP) is a rare inborn error of bone and mineral metabolism characterized by a defect in the tissue non-specific alkaline phosphatase (TNSALP) gene. Calcium pyrophosphate dihydrate (CPPD) crystals are known to accumulate as substrates of TNSALP in tissues and joints of patients with HP. In CPPD-induced arthritis these crystals are known to induce an inflammatory response. HP patients do suffer from pain in their lower extremities. However, it is not clear whether CPPD crystals contribute to these musculoskeletal complaints in HP...
January 2009: Rheumatology International
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