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TREM pain

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https://www.readbyqxmd.com/read/27792788/trem-1-hmgb1-and-rage-in-the-shoulder-tendon-dual-mechanisms-for-inflammation-based-on-the-coincidence-of-glenohumeral-arthritis
#1
Finosh G Thankam, Matthew F Dilisio, Nicholas E Dietz, Devendra K Agrawal
Rotator cuff injury (RCI) is a major musculoskeletal disorder in the adult population where inflammation and pain are major contributing factors. Coincidence of other clinical conditions like glenohumeral arthritis aggravates inflammation and delays the healing response. The mechanism and signaling factors underlying the sustenance of inflammation in the rotator cuff joint are largely unknown. The present article aims to elucidate the involvement of inflammatory molecule, TREM-1 (Triggering Receptors Expressed on Myeloid cells-1), and danger-associated molecular patterns (DAMPs), including high mobility group protein 1 (HMGB-1) and RAGE (receptor for advanced glycation end products), in the setting of RCI with respect to the severity of glenohumeral arthritis...
2016: PloS One
https://www.readbyqxmd.com/read/25147325/levels-of-soluble-trem-like-transcript-1-in-patients-presenting-to-the-emergency-department-with-chest-pain
#2
Omar L Esponda, Robert Hunter, José R Rivera Del Río, A Valance Washington
OBJECTIVE: Recent studies suggest that the soluble triggering receptor expressed on myeloid cells-like transcript 1 (sTLT-1) facilitate atherothrombosis. Therefore, we evaluated sTLT-1 as a functional measure of atherothrombosis in acute coronary syndrome (ACS). METHODS: Levels of sTLT-1 were determined by enzyme-linked immunosorbent assay on plasma from patients with potential ACS and compared with an age-matched control group with similar risk factors for cardiovascular disease...
January 2015: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/21114709/triggering-receptor-trem-1-expressed-on-myeloid-cells-predicts-bacteremia-better-than-clinical-variables-in-community-acquired-pneumonia
#3
Agustin Ruiz-González, Aureli Esquerda, Miquel Falguera, Nadia Abdulghani, Pamela Cabezas, Silvia Bielsa, José M Porcel
BACKGROUND AND OBJECTIVE: Some clinical variables are associated with bacteremia in patients with community-acquired pneumonia (CAP). The aim of this study was to analyse the accuracy of the soluble form of triggering receptor expressed on myeloid cells-1 (sTREM-1) to predict positive blood cultures in comparison with established clinical prognostic variables. METHODS: In addition to collecting clinical and laboratory information, a commercially available immunoassay kit was used to measure the serum sTREM-1 levels on the first day of admit ion in patients with CAP...
February 2011: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/18821074/how-can-calcium-pyrophosphate-crystals-induce-inflammation-in-hypophosphatasia-or-chronic-inflammatory-joint-diseases
#4
REVIEW
C Beck, H Morbach, P Richl, M Stenzel, H J Girschick
Hypophosphatasia (HP) is a rare inborn error of bone and mineral metabolism characterized by a defect in the tissue non-specific alkaline phosphatase (TNSALP) gene. Calcium pyrophosphate dihydrate (CPPD) crystals are known to accumulate as substrates of TNSALP in tissues and joints of patients with HP. In CPPD-induced arthritis these crystals are known to induce an inflammatory response. HP patients do suffer from pain in their lower extremities. However, it is not clear whether CPPD crystals contribute to these musculoskeletal complaints in HP...
January 2009: Rheumatology International
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