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https://www.readbyqxmd.com/read/25360872/modulating-cd4-t-cell-migration-in-the-postischemic-liver-hepatic-stellate-cells-as-new-therapeutic-target
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Jörg Reifart, Markus Rentsch, Konstantin Mende, Raffaele Coletti, Monika Sobocan, Wolfgang E Thasler, Andrej Khandoga
BACKGROUND: CD4+ T cells play a critical role during hepatic ischemia-reperfusion (I/R) injury although the mechanisms of their migration in the postischemic liver remain unclear. We answered the questions of whether hepatic stellate cells (HSCs) interact with CD4+ T cells during I/R of the liver and whether modulation of HSC activity affects T cell-dependent I/R injury. METHODS: In mice, migration of CD4+ T cells was analyzed in vivo using conventional intravital microscopy and two-photon microscopy...
January 2015: Transplantation
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