keyword
MENU ▼
Read by QxMD icon Read
search

TSPO CSF

keyword
https://www.readbyqxmd.com/read/27578213/assessment-of-neuroinflammation-in-a-mouse-model-of-obesity-and-%C3%AE-amyloidosis-using-pet
#1
Anna M Barron, Masaki Tokunaga, Ming-Rong Zhang, Bin Ji, Tetsuya Suhara, Makoto Higuchi
BACKGROUND: Obesity has been identified as a risk factor for cognitive decline and Alzheimer's disease (AD). The aim of this study was to investigate the effect of obesity on neuroinflammation and cerebral glucose metabolism using PET in a mouse model of β-amyloidosis and determine the relationship between these PET imaging biomarkers, pathogenic changes, and functional outcomes. METHODS: Three-month-old C57BL/J6 mice were fed either a standard (control group) or high-fat diet (obese group) for 3 months and intracerebroventricularly infused with vehicle or human beta amyloid 1-42 (Aβ42)...
August 31, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27070405/in-vivo-markers-of-inflammatory-response-in-recent-onset-schizophrenia-a-combined-study-using-11-c-dpa-713-pet-and-analysis-of-csf-and-plasma
#2
J M Coughlin, Y Wang, E B Ambinder, R E Ward, I Minn, M Vranesic, P K Kim, C N Ford, C Higgs, L N Hayes, D J Schretlen, R F Dannals, M Kassiou, A Sawa, M G Pomper
Several lines of evidence suggest aberrant immune response in schizophrenia, including elevated levels of cytokines. These cytokines are thought to be produced by activated microglia, the innate immune cells of the central nervous system. However, increase in translocator protein 18 kDa (TSPO), a marker of activated glia, has not been found in patients with chronic schizophrenia using second-generation radiotracers and positron emission tomography (PET)-based neuroimaging. In this study we focused on patients with recent onset of schizophrenia (within 5 years of diagnosis)...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/26911637/neuroinflammation-in-treated-hiv-positive-individuals-a-tspo-pet-study
#3
Jaime H Vera, Qi Guo, James H Cole, Adriano Boasso, Louise Greathead, Peter Kelleher, Eugenii A Rabiner, Nicola Kalk, Courtney Bishop, Roger N Gunn, Paul M Matthews, Alan Winston
OBJECTIVE: To explore the effects of microglial activation on brain function and structure, and its relationship with peripheral inflammatory markers, in treated, HIV-positive individuals, using in vivo [(11)C]PBR28 PET (to measure the 18 kDa translocator protein [TSPO]). METHODS: Cognitively healthy HIV-positive individuals on suppressive antiretroviral therapy and HIV-negative individuals (controls) underwent brain [(11)C]PBR28 PET and MRI. HIV-positive patients completed neuropsychological testing and CSF testing for chemokines...
April 12, 2016: Neurology
https://www.readbyqxmd.com/read/24215796/the-role-of-allopregnanolone-in-depression-and-anxiety
#4
REVIEW
Cornelius Schüle, Caroline Nothdurfter, Rainer Rupprecht
Neuroactive steroids such as allopregnanolone do not only act as transcriptional factors in the regulation of gene expression after intracellular back-oxidation into the 5-α pregnane steroids but may also alter neuronal excitability through interactions with specific neurotransmitter receptors. In particular, certain 3α-reduced metabolites of progesterone such as 3α,5α-tetrahydroprogesterone (allopregnanolone) and 3α,5β-tetrahydroprogesterone (pregnanolone) are potent positive allosteric modulators of the GABA(A) receptor complex...
February 2014: Progress in Neurobiology
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"