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https://www.readbyqxmd.com/read/27906511/finding-a-new-crystalline-sponge-from-a-crystallographic-database
#1
Yasuhide Inokuma, Kazuki Matsumura, Shota Yoshioka, Makoto Fujita
Empirical searching conditions were adopted to identify suitable candidates from the Cambridge Structural Database (CSD) for crystalline sponge hosts for X-ray crystallographic analysis of incoming guest compounds. After optimization of the solvent and soaking conditions, one of the candidates was used as a crystalline sponge for the structure determination of an aromatic guest.
December 1, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27906503/neurodevelopmental-disorders
#2
REVIEW
Hana D'Souza, Annette Karmiloff-Smith
Recent technological advances allow us to measure how the infant brain functions in ways that were not possible just a decade ago. Although methodological advances are exciting, we must also consider how theories guide research: what we look for and how we explain what we find. Indeed, the ways in which research findings are interpreted affects the design of policies, educational practices, and interventions. Thus, the theoretical approaches adopted by scientists have a real impact on the lives of children with neurodevelopmental disorders (NDDs) and their families, as well as on the wider community...
December 1, 2016: Wiley Interdisciplinary Reviews. Cognitive Science
https://www.readbyqxmd.com/read/27906454/immunotherapy-of-head-and-neck-cancer-emerging-clinical-trials-from-a-national-cancer-institute-head-and-neck-cancer-steering-committee-planning-meeting
#3
Julie E Bauman, Ezra Cohen, Robert L Ferris, David J Adelstein, David M Brizel, John A Ridge, Brian O'Sullivan, Barbara A Burtness, Lisa H Butterfield, William E Carson, Mary L Disis, Bernard A Fox, Thomas F Gajewski, Maura L Gillison, James W Hodge, Quynh-Thu Le, David Raben, Scott E Strome, Jean Lynn, Shakun Malik
Recent advances have permitted successful therapeutic targeting of the immune system in head and neck squamous cell carcinoma (HNSCC). These new immunotherapeutic targets and agents are being rapidly adopted by the oncologic community and hold considerable promise. The National Cancer Institute sponsored a Clinical Trials Planning Meeting to address the issue of how to further investigate the use of immunotherapy in patients with HNSCC. The goals of the meeting were to consider phase 2 or 3 trial designs primarily in 3 different patient populations: those with previously untreated, human papillomavirus-initiated oropharyngeal cancers; those with previously untreated, human papillomavirus-negative HNSCC; and those with recurrent/metastatic HNSCC...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27906448/a-randomized-controlled-trial-of-a-multicomponent-targeted-low-literacy-educational-intervention-compared-with-a-nontargeted-intervention-to-boost-colorectal-cancer-screening-with-fecal-immunochemical-testing-in-community-clinics
#4
Stacy N Davis, Shannon M Christy, Enmanuel A Chavarria, Rania Abdulla, Steven K Sutton, Alyssa R Schmidt, Susan T Vadaparampil, Gwendolyn P Quinn, Vani N Simmons, Chukwudi B Ufondu, Chitra Ravindra, Ida Schultz, Richard G Roetzheim, David Shibata, Cathy D Meade, Clement K Gwede
BACKGROUND: The objective of the current study was to improve colorectal cancer (CRC) screening uptake with the fecal immunochemical test (FIT). The current study investigated the differential impact of a multicomponent, targeted, low-literacy educational intervention compared with a standard, nontargeted educational intervention. METHODS: Patients aged 50 to 75 years who were of average CRC risk and not up-to-date with CRC screening were recruited from either a federally qualified health center or a primary care community health clinic...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27906440/supramicrosurgical-lymphatico-venular-anastomosis-lva-in-treating-lymphoedema-36-months-preliminary-report
#5
P Gennaro, G Gabriele, M Mihara, K Kikuchi, C Salini, I Aboh, F Cascino, G Chisci, C Ungari
OBJECTIVE: Lymphoedema of the extremities is a widespread pathological condition that mostly occurs as a complication of cancer resections, especially in women. Conventional therapy refers to conservative and physiotherapeutic approaches. Surgical strategies have been widely reported in the literature and are still challenging. Part of this literature focuses on the supra microsurgical lymphaticovenular anastomosis (LVA) technique. LVA is characterized by a high success rate, minimal invasivity and broad indications...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27906432/analysis-of-radiotherapy-optimization-regimens-after-modified-radical-mastectomy
#6
X-B Zhao, G-S Ren
OBJECTIVE: Concomitant chemo-radiotherapy after modified radical mastectomy for breast cancer is an effective means of achieving high survival rates. In this study different radiotherapy optimization regimens are compared to assess their effectiveness and toxicity rates. PATIENTS AND METHODS: 112 patients with modified radical mastectomy participated, and were randomly assigned to one of three groups, all receiving adjuvant chemotherapy for 4-6 weeks prior to radiotherapy: group A received intensity modulated radiotherapy (radiation dose (DT) 50 Gy, 2...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27906381/video-stabilization-in-atmosphere-turbulent-conditions-based-on-the-laplacian-riesz-pyramid
#7
Bindang Xue, Yi Liu, Linyan Cui, Xiangzhi Bai, Xiaoguang Cao, Fugen Zhou
Video stabilization in atmosphere turbulent conditions is aimed at removing spatiotemporally varying distortions from video recordings. Conventional shaky video stabilization approaches do not perform effectively under turbulent circumstances due to the erratic motion common to those conditions. Using complex-valued image pyramids, we propose a method to mitigate this erratic motion in videos. First, each frame of a video is decomposed into different spatial frequencies using the Laplacian pyramid. Second, a Riesz transform is adopted to extract the local amplitude and the local phase of each sub-band...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906362/2-sup-16-sup-shades-of-gray-high-bit-depth-projection-using-light-intensity-control
#8
Jen-Hao Rick Chang, B V K Vijaya Kumar, Aswin C Sankaranarayanan
Projectors create grayscale images by outputting a series of bitplanes or binary images within a short time period. While this technique works well for projecting low bit-depth (8-bit) images, it becomes infeasible for high bit-depth (say, 16-bit) projection - a capability that is increasingly desirable in many applications including cinemas and gaming. Existing designs for high bit-depth projection rely on multiple spatial light modulators and, as a consequence, their costs and complexities are usually far beyond the average consumer...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906329/self-healing-highly-chirped-fiber-laser-at-1-0-%C3%AE-m
#9
Xiaoming Wei, Cihang Kong, Goutam K Samanta, Kevin K Tsia, Kenneth K Y Wong
We demonstrate a MHz wavelength-swept fiber laser with diffraction-free and self-healing properties at the bio-favorable wavelength window of 1.0 μm. This ultrafast wavelength sweeping at a high chirp rate is all-optically realized through a newly-designed dispersive fiber that can provide a dispersion amount up to -1.7 ns/nm. It is 8 times larger than the standard single-mode fiber at this window and by adopting a double-pass configuration, the dispersion amount can be further increased to about -3.5 ns/nm, which is 23 times larger than what has previously been demonstrated...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906028/re-focusing-hiv-prevention-messages-a-qualitative-study-in-rural-uganda
#10
Sanyukta Mathur, Dina Romo, Mariko Rasmussen, Neema Nakyanjo, Fred Nalugoda, John S Santelli
BACKGROUND: After 30 years, the human immunodeficiency virus (HIV) remains an epidemic of global concern. To support the increasing emphasis on biomedical interventions for prevention requires a renewed and reframed focus on HIV prevention messages to motivate engagement in risk-reduction activities. This paper examines youth and adult perceptions of HIV prevention messages and HIV risk assessment in a generalized HIV epidemic context in Uganda. METHODS: We conducted 24 focus group discussions and 24 in-depth interviews with 15-45 year olds (n = 218) from three communities in the Rakai district of Uganda in 2012...
November 11, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27905994/the-role-of-il-10-in-mycobacterium-avium-subsp-paratuberculosis-infection
#11
REVIEW
Tariq Hussain, Syed Zahid Ali Shah, Deming Zhao, Srinand Sreevatsan, Xiangmei Zhou
Mycobacterium avium subsp. paratuberculosis (MAP) is an intracellular pathogen and is the causative agent of Johne's disease of domestic and wild ruminants. Johne's disease is characterized by chronic granulomatous enteritis leading to substantial economic losses to the livestock sector across the world. MAP persistently survives in phagocytic cells, most commonly in macrophages by disrupting its early antibacterial activity. MAP triggers several signaling pathways after attachment to pathogen recognition receptors (PRRs) of phagocytic cells...
December 1, 2016: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/27905941/financing-strategies-to-improve-essential-public-health-equalization-and-its-effects-in-china
#12
Li Yang, Li Sun, Liankui Wen, Huyang Zhang, Chenyang Li, Kara Hanson, Hai Fang
BACKGROUND: In 2009, China launched a health reform to promote the equalization of national essential public health services package (NEPHSP). The present study aimed to describe the financing strategies and mechanisms to improve access to public health for all, identify the strengths and weaknesses of the different approaches, and showed evidence on equity improvement among different regions. METHODS: We reviewed the relevant literatures and identified 208 articles after screening and quality assessment and conducted six key informants' interviews...
December 1, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27905920/synergistic-effects-and-related-bioactive-mechanism-of-potentilla-fruticosa-l-leaves-combined-with-ginkgo-biloba-extracts-studied-with-microbial-test-system-mts
#13
Ze-Hua Liu, Dong-Mei Wang, Su-Fang Fan, Deng-Wu Li, Zi-Wen Luo
BACKGROUND: Potentilla fruticosa, also called "Jinlaomei" and "Gesanghua", is widely used as folk herbs in traditional Tibetan medicine in China to treat inflammations, wounds, certain forms of cancer, diarrhoea, diabetes and other ailments. Previous research found P. fruticosa leaf extract (C-3) combined with Ginkgo biloba extracts (EGb) showed obvious synergistic effects in a variety of oxidation systems. The aim of the present study was to further confirm the synergy of P. fruticosa combined with EGb viewed from physiological bioavailability and explore the related bioactive mechanism behind the synergism...
December 1, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27905904/evaluating-the-implementation-process-of-a-participatory-organizational-level-occupational-health-intervention-in-schools
#14
Roosmarijn M C Schelvis, Noortje M Wiezer, Birgitte M Blatter, Joost A G M van Genabeek, Karen M Oude Hengel, Ernst T Bohlmeijer, Allard J van der Beek
BACKGROUND: The importance of process evaluations in examining how and why interventions are (un) successful is increasingly recognized. Process evaluations mainly studied the implementation process and the quality of the implementation (fidelity). However, in adopting this approach for participatory organizational level occupational health interventions, important aspects such as context and participants perceptions are missing. Our objective was to systematically describe the implementation process of a participatory organizational level occupational health intervention aimed at reducing work stress and increasing vitality in two schools by applying a framework that covers aspects of the intervention and its implementation as well as the context and participants perceptions...
December 1, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27905871/phyinformr-phylogenetic-experimental-design-and-phylogenomic-data-exploration-in-r
#15
Alex Dornburg, J Nick Fisk, Jules Tamagnan, Jeffrey P Townsend
BACKGROUND: Analyses of phylogenetic informativeness represent an important step in screening potential or existing datasets for their proclivity toward convergent or parallel evolution of molecular sites. However, while new theory has been developed from which to predict the utility of sequence data, adoption of these advances have been stymied by a lack of software enabling application of advances in theory, especially for large next-generation sequence data sets. Moreover, there are no theoretical barriers to application of the phylogenetic informativeness or the calculation of quartet internode resolution probabilities in a Bayesian setting that more robustly accounts for uncertainty, yet there is no software with which a computationally intensive Bayesian approach to experimental design could be implemented...
December 1, 2016: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/27905588/phase-specific-dispersion-of-functional-nanoparticles-in-soft-nanocomposites-resulting-in-enhanced-electromagnetic-screening-ability-dominated-by-absorption
#16
Aishwarya V Menon, Giridhar Madras, Suryasarathi Bose
The effect of phase specific localisation of MWNTs (multiwalled carbon nanotubes) and magnetic FeNi (iron-nickel) alloy particles on bulk electrical conductivity and electromagnetic (EM) wave attenuation was investigated in biphasic co-continuous blends of PVDF/SMA (polyvinylidene fluoride/styrene maleic anhydride). It is envisaged that packing different functional nanoparticles in a given phase of a co-continuous blend can impede the charge transport phenomenon and the overall dispersion state. Therefore, phase specific localisation can facilitate the tuning of the functional properties in biphasic blends...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27905532/validation-of-plasma-micrornas-as-biomarkers-for-myotonic-dystrophy-type-1
#17
A Perfetti, S Greco, R Cardani, B Fossati, G Cuomo, R Valaperta, F Ambrogi, A Cortese, A Botta, A Mignarri, M Santoro, C Gaetano, E Costa, M T Dotti, G Silvestri, R Massa, G Meola, F Martelli
Non-invasive and simple to measure biomarkers are still an unmet need for myotonic dystrophy type 1 (DM1). Indeed, muscle biopsies can be extremely informative, but their invasive nature limits their application. Extracellular microRNAs are emerging humoral biomarkers and preliminary studies identified a group of miRNAs that are deregulated in the plasma or serum of small groups of DM1 patients. Here we adopted very stringent selection and normalization criteria to validate or disprove these miRNAs in 103 DM1 patients and 111 matched controls...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905470/a-previously-unreported-impact-of-a-pla2g7-gene-polymorphism-on-the-plasma-levels-of-lipoprotein-associated-phospholipase-a2-activity-and-mass
#18
Yue Qi, Dong Zhao, Zhangrong Jia, Wei Wang, Miao Wang, Jiayi Sun, Jun Liu, Yan Li, Wuxiang Xie, Jing Liu
Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are associated with the development of atherosclerosis. We aimed to assess the genetic determinants of Lp-PLA2 activity and mass by genotyping multiple polymorphisms in PLA2G7, the gene encoding Lp-PLA2, among 1258 participants from the Chinese Multi-provincial Cohort Study-Beijing Project. The Sequenom MassARRAY system, Taqman assay and direct sequencing were adopted. For the first time, the rs13218408 polymorphism was found to be significantly associated with reduced Lp-PLA2 levels...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905285/the-current-status-of-ticks-in-turkey-a-100-year-period-review-from-1916-to-2016
#19
Abdullah İnci, Alparslan Yıldırım, Önder Düzlü
Environmental and bio-ecological changes, some administrative and political mistakes, and global warming seriously affect the behaviors of ticks in Turkey and globally. The global public sensitivity toward tick infestations has increased along with increases in tick-borne diseases (TBDs). Recently, the World Health Organization (WHO) developed a new political concept, "One Health," for specific struggle strategies against tick infestations and TBDs. To highlight the importance of the issue, the WHO had declared the year 2015 for vector-borne diseases and adopted the slogan "small bites big threat"...
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27905247/consultation-on-changes-to-technology-appraisals
#20
(no author information available yet)
A joint consultation by the National Institute for Health and Care Excellence (NICE) and NHS England sets out changes to the arrangements for evaluating and funding drugs, and for other health technologies appraised through NICE's relevant programmes. The aims of the consultation are to: » Give patients quicker access to the most cost-effective new treatments. » Offer more flexibility in the adoption of cost-effective, high-budget impact technologies in the NHS. » Provide greater clarity for patients and companies about when NICE-appraised treatments for rare conditions will automatically qualify for funding from routine commissioning budgets...
December 1, 2016: Nursing Management (Harrow)
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