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https://www.readbyqxmd.com/read/28945045/-real-world-analysis-to-explore-clinical-features-of-shenxiong-glucose-injection-combined-with-other-medications
#1
Gui-Qian Wang, Yan-Ming Xie, Huan Liu, Yin Zhang, Ping-Ping Jia, Yan Zhuang
To explore the real world clinical medication and combination characteristics of Shenxiong glucose injection. The basic information of patients with Shenxiong glucose injection, traditional Chinese and western medicine diagnosis information, doctor advice information and laboratory test information from the hospital information system(HIS) of 19 tertiary hospitals in China. Apriori algorithm was adopted to establish the models, and Clementine 12.0 was used for correlation analysis to analyze the real world clinical medication and combination characteristics of Shenxiong glucose injection...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945042/-effect-of-compound-longmaining-decoction-with-different-combinations-on-intestinal-absorption-of-puerarin
#2
Xi-Hui Bai, Shi-Yu Liu, Jing Wang, Chang-Li Wang, Xiao Song
To study the effects of compound Longmaining(FFLMN) with different combinations on the intestinal absorption of puerarin. The rat single pass intestinal perfusion model was adopted, and the concentration of puerarin in intestinal samples was determined by HPLC. The effects of different combination groups on the absorption of puerarin in duodenum, jejunum, ileum and colon were investigated. The combined drugs were GG(Puerariae Lobatae Radix), GG-CSL (Puerariae Lobatae Radix compared with Dioscoreae Nipponicae Rhizoma), GG-CX(Puerariae Lobatae Radix compared with Chuanxiong Rhizoma) and FFLMN (compound Longmaining)...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945036/-effect-of-vinegar-processing-on-esculentosides-in-n-buoh-fraction-and-main-toxic-components-in-phytolaccae-radix
#3
Hong-Li Yu, Cheng-Chao Zhang, Hao Wu, Kui-Long Wang, Wei Wang, Xue-Lian Shan
This study was to investigate the effect of vinegar processing on esculentosides in n-BuOH fraction and the contents of the main toxic components esculentoside B (EsB) and esculentoside C (EsC) in Phytolaccae Radix pieces. n-BuOH fraction of Phytolaccae Radix pieces was processed with vinegar according to the processing method in Chinese Pharmacopoeia. HPLC-MS-MS was adopted to analyze the esculentosides composition changes in n-BuOH fraction before and after vinegar processing. HPLC-ELSD was used to detect EsC and EsB contents in raw and vinegar processed Phytolaccae Radix pieces, and investigate the content changes before and after vinegar processing...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944610/last-century-forest-productivity-in-a-managed-dry-edge-scots-pine-population-the-two-sides-of-climate-warming
#4
Laura Marqués, Jaime Madrigal-González, Miguel A Zavala, J Julio Camarero, Florian Hartig
Climate change in the Mediterranean, associated with warmer temperatures and more frequent droughts, is expected to impact forest productivity and the functioning of forests ecosystems as carbon reservoirs in the region. Climate warming can positively affect forest growth by extending the growing season, whereas increasing summer drought generally reduces forest productivity and may cause growth decline, trigger dieback, hamper regeneration and increase mortality. Forest management could potentially counteract such negative effects by reducing stand density and thereby competition for water...
September 25, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28944593/fifty-years-of-behavioral-lifestyle-interventions-for-overweight-and-obesity-where-have-we-been-and-where-are-we-going
#5
REVIEW
Donald A Williamson
OBJECTIVE: This paper reviews the literature pertaining to the structure and content of intensive lifestyle interventions (ILIs) for overweight/obesity since Richard Stuart described this new treatment approach in 1967. A consensus opinion has formed that behavioral/lifestyle treatment of overweight and obesity should be viewed as a mainstream intervention for the treatment and prevention of type 2 diabetes and medical complications associated with obesity. METHODS: The development of modern ILIs and demonstration of their efficacy are compared by structure, content, and efficacy of four major randomized controlled trials: Diabetes Prevention Program (DPP), Look AHEAD, POUNDS Lost, and CALERIE...
September 25, 2017: Obesity
https://www.readbyqxmd.com/read/28944511/cost-utility-analysis-of-direct-vad-versus-double-bridges-to-heart-transplantation-in-patients-with-refractory-heart-failure
#6
Hsiao-Huang Chang, Po-Lin Chen, I-Ming Chen, Tzu-Ting Kuo, Zen-Chung Weng, Pei-Jung Huang, Nai-Yuan Wu, Ching-Li Cheng
OBJECT: This study compared the cost-utility of direct ventricular assist device (VAD) versus double bridges, extracorporeal membrane oxygenation (ECMO) before VAD, to heart transplantation in patients with refractory heart failure. MATERIALS AND METHODS: From a health payer perspective, a Markov model was developed. The cycle length was one month and the time horizon was a lifetime. Probabilities and direct cost data were calculated from a nationwide claim database...
September 25, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28944489/using-systematic-review-in-occupational-safety-and-health
#7
John Howard, John Piacentino, Kathleen MacMahon, Paul Schulte
Evaluation of scientific evidence is critical in developing recommendations to reduce risk. Healthcare was the first scientific field to employ a systematic review approach for synthesizing research findings to support evidence-based decision-making and it is still the largest producer and consumer of systematic reviews. Systematic reviews in the field of occupational safety and health are being conducted, but more widespread use and adoption would strengthen assessments. In 2016, NIOSH asked RAND to develop a framework for applying the traditional systematic review elements to the field of occupational safety and health...
September 25, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28944434/informal-e-waste-recycling-in-developing-countries-review-of-metal-loid-s-pollution-environmental-impacts-and-transport-pathways
#8
Michael Ackah
Crude or primitive recycling practices are often adopted in material resource recovery from E-waste in developing nations. Significant human health and environmental impacts may occur because of such practices. Literature on metal(loid)s pollution during E-waste processing is fragmented. Here, I review the health and environmental impacts of E-waste recycling operations and transport pathways of metal(loid)s, dispersed during operations. This paper is organised into five sections. Section 1 relates to the background of global E-waste generation and legal/illegal trade, citing specific cases from Ghana and other developing nations...
September 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28944389/synthesis-structure-and-photophysics-of-copper-i-triphenylphosphine-complexes-with-functionalized-3-2-pyrimidinyl-1-2-4-triazole-ligands
#9
Jing-Lin Chen, Xue-Hua Zeng, Yan-Sheng Luo, Wan-Man Wang, Li-Hua He, Sui-Jun Liu, He-Rui Wen, Shuping Huang, Li Liu, Wai-Yeung Wong
A series of new mononuclear and dinuclear copper(i) triphenylphosphine complexes with functionalized 3-(2'-pyrimidinyl)-1,2,4-triazole ligands have been synthesized and characterized, in which functionalized 3-(2'-pyrimidinyl)-1,2,4-triazole adopts neutral mono- and bis-chelating coordination modes and a mono-anionic bis-chelating binding manner due to the 1,2,4-triazolyl-NH deprotonation. All these Cu(i) complexes display a relatively weak low-energy absorption in a CH2Cl2 solution, ascribed to the charge-transfer transitions with appreciable MLCT character, as suggested by TD-DFT analyses...
September 25, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28944222/fetal-heart-sounds-detection-using-wavelet-transform-and-fractal-dimension
#10
Elisavet Koutsiana, Leontios J Hadjileontiadis, Ioanna Chouvarda, Ahsan H Khandoker
Phonocardiography is a non-invasive technique for the detection of fetal heart sounds (fHSs). In this study, analysis of fetal phonocardiograph (fPCG) signals, in order to achieve fetal heartbeat segmentation, is proposed. The proposed approach (namely WT-FD) is a wavelet transform (WT)-based method that combines fractal dimension (FD) analysis in the WT domain for the extraction of fHSs from the underlying noise. Its adoption in this field stems from its successful use in the fields of lung and bowel sounds de-noising analysis...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28943401/crystal-structure-of-l-glutamate-n-acetyltransferase-arga-from-mycobacterium-tuberculosis
#11
Xiuna Yang, Lijie Wu, Yajun Ran, Ao Xu, Bing Zhang, Xiaolin Yang, Rongguang Zhang, Zihe Rao, Jun Li
l-arginine is used as a source of both carbon and nitrogen in Mycobacterium tuberculosis (Mtb) and its biosynthesis is essential for the pathogen's survival. MtbArgA (Rv2747) catalyzes the initial step in l-arginine biosynthesis by transferring an acetyl group from acetyl coenzyme A (AcCoA) to l-glutamate. MtbArgA is a class III N-acetylglutamate synthase (NAGS) with no structural information. Here, we solved the crystal structure of MtbArgA complexed with AcCoA and l-glutamate. The overall structure adopts a classic fold of the GCN5-related N-acetyltransferase (GNAT) family, characterized by a "V"-shaped cleft and β-bulge, but uses distinct residues for the binding and reaction of AcCoA...
September 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28943296/il-33-exacerbates-liver-sterile-inflammation-by-amplifying-neutrophil-extracellular-trap-formation
#12
Hamza O Yazdani, Hui-Wei Chen, Samer Tohme, Sheng Tai, Dirk J van der Windt, Patricia Loughran, Brian R Rosborough, Vikas Sud, Donna Beer-Stolz, Heth R Turnquist, Allan Tsung, Hai Huang
BACKGROUND: Neutrophils and Liver sinusoidal endothelial cells (LSECs) both contribute to sterile inflammatory injury during ischemia/reperfusion (I/R), a well-known liver surgical stress. Interleukin-33 (IL-33) has been shown to drive neutrophil infiltration during inflammatory responses through its receptor ST2. We recently reported that infiltrating neutrophils form neutrophil extracellular traps (NETs), which exacerbate sterile inflammatory injury in liver I/R. Here, we sought to determine the role of IL-33 in NET formation during liver sterile inflammation...
September 21, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28943187/con-factor-concentrate-usage-in-cardiac-surgery-a-paucity-of-data-limits-their-universal-adoption
#13
Lindsay Raleigh, Sheela Pai Cole
No abstract text is available yet for this article.
May 3, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28943156/a-continuum-theoretical-model-and-finite-elements-simulation-of-bacterial-flagellar-filament-phase-transition
#14
REVIEW
Xiaoling Wang, Shuo Meng, Jingshi Han
The Bacterial flagellar filament can undergo a polymorphic phase transition in response to both mechanical and chemical variations in vitro and in vivo environments. Under mechanical stimuli, such as viscous flow or forces induced by motor rotation, the filament changes its phase from left-handed normal (N) to right-handed semi-coiled (SC) via phase nucleation and growth. Our detailed mechanical analysis of existing experiments shows that both torque and bending moment contribute to the filament phase transition...
September 14, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28943093/naturak-killer-cell-immunotherapies-against-cancer-checkpoint-inhibitors-and-more
#15
REVIEW
Laura Chiossone, Margaux Vienne, Yann M Kerdiles, Eric Vivier
After many years of research, recent advances have shed new light on the role of the immune system in advanced-stage cancer. Various types of immune cells may be useful for therapeutic purposes, along with chemical molecules and engineered monoclonal antibodies. The immune effectors suitable for manipulation for adoptive transfer or drug targeting in vivo include natural killer (NK) cells. These cells are of particular interest because they are tightly regulated by an array of inhibitory and activating receptors, enabling them to kill tumor cells while sparing normal cells...
September 21, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28943063/outpatient-laparoscopic-appendectomy-can-be-successfully-performed-for-uncomplicated-appendicitis-a-southwestern-surgical-congress-multicenter-trial
#16
Richard Frazee, Clay Cothren Burlew, Justin Regner, Robert McIntyre, Erik Peltz, Chris Cribari, Julie Dunn, Larry Butler, Paul Reckard, Sharmila Dissanaike, Karen Karimi, Charles Behnfield, Nic Melo, Daniel Margulies
BACKGROUND: Many laparoscopic procedures are now performed on an outpatient basis. We hypothesize laparoscopic appendectomy can be safely performed as an outpatient procedure. METHODS: Seven institutions adopted a previously described outpatient laparoscopic appendectomy protocol for uncomplicated appendicitis. Patients were dismissed unless there was a clinical indication for admission. Patient demographics, success with outpatient management, time of dismissal, morbidity, and readmissions were analyzed...
September 19, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28942945/polysaccharides-derived-from-ganoderma-lucidum-fungus-mycelia-ameliorate-indomethacin-induced-small-intestinal-injury-via-induction-of-gm-csf-from-macrophages
#17
Kenta Nagai, Yoshitaka Ueno, Shinji Tanaka, Ryohei Hayashi, Kei Shinagawa, Kazuaki Chayama
Non-steroidal anti-inflammatory drugs often cause ulcers in the human small intestine, but few effective agents exist to treat such injury. Ganoderma lucidum Karst, also known as "Reishi" or "Lingzhi", is a mushroom. We previously reported that a water-soluble extract from G. lucidum fungus mycelia (MAK) has anti-inflammatory effects in murine colitis induced by trinitrobenzene sulfonic acid, and induction of granulocyte macrophage colony-stimulating factor (GM-CSF) by MAK may provide anti-inflammatory effects...
August 4, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28942912/an-evolving-role-for-cancer-rehabilitation-in-the-era-of-low-dose-lung-computed-tomography-screening
#18
REVIEW
Sean Robinson Smith, Ashish Khanna, Eric M Wisotzky
Lung cancer is the number one cause of cancer-related death worldwide, and is often detected in the later stages. Use of low-dose chest computed tomography in at-risk patients provides earlier detection and is being adopted as the standard screening tool, replacing less precise methods of radiography and sputum cytology. In the past, late detection of disease meant that rehabilitation interventions attempted to salvage function and to improve aerobic capacity to the point where patients could tolerate the sometimes-extensive oncologic treatment, including lobectomy or pneumonectomy...
September 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28942886/who-treats-lung-cancer-results-from-a-global-survey
#19
Takefumi Komiya, Christine B Mackay, Prabhakar Chalise
BACKGROUND: In most Western nations, the medical oncologist plays a significant role in the administration of systemic therapy for lung cancer. In Japan however, treatment for lung cancer has historically been provided by pulmonologists and thoracic surgeons. A comparison of the management of advanced disease between Japan and other nations has not been described. METHODS: An online, self-administered, international survey was sent to 3907 active members of the American Society of Clinical Oncology...
September 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28942724/current-models-of-support-from-community-pharmacies-for-patients-on-oral-anticancer-medicines
#20
Melanie Dalby
Administration of chemotherapy is moving into the community as more and more therapies to treat cancer are being developed as oral medications. Patients taking these oral medications still require support, as many of these agents can be toxic. This support could be simple side effect management, compliance issues or even reassurance with regards to their diagnosis as examples. Community pharmacies are ideally placed within the community to help these patients. The purpose of this review is to determine what support community pharmacies are currently providing for patients taking oral anticancer medication and if there is a model that can be adopted or adapted to be used elsewhere...
January 1, 2017: Journal of Oncology Pharmacy Practice
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