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https://www.readbyqxmd.com/read/29678910/serotype-diversity-and-antimicrobial-resistance-among-salmonella-enterica-isolated-from-patients-at-an-equine-referral-hospital
#1
I M Leon, S D Lawhon, K N Norman, D S Threadgill, N Ohta, J Vinasco, H M Scott
Although Salmonella enterica can produce life-threatening colitis in horses, certain serotypes are more commonly associated with clinical disease. Our aim was to evaluate the proportional morbidity attributed to different serotypes, as well as phenotypic and genotypic antimicrobial resistance (AMR) of Salmonella isolated from patients at an equine referral hospital in the southern United States. Two-hundred-fifty-five Salmonella isolates were obtained from clinical samples of patients admitted to the hospital between 2007 and 2015...
April 20, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29675942/occurrence-of-plasmid-mediated-quinolone-resistance-genes-in-escherichia-coli-and-klebsiella-spp-recovered-from-corvus-brachyrhynchos-and-corvus-corax-roosting-in-canada
#2
Nicol Janecko, Dana Halova, Ivana Jamborova, Ivo Papousek, Martina Masarikova, Monika Dolejska, Ivan Literak
The spread of antimicrobial resistance from human activity derived sources to natural habitats implicates wildlife as potential vectors of antimicrobial resistance transfer. Wild birds, including corvid species can disseminate mobile genetic resistance determinants through feces. This study aimed to determine the occurrence of plasmid-mediated quinolone resistance (PMQR) genes in Escherichia coli and Klebsiella spp. isolates obtained from winter roosting sites of American crows (Corvus brachyrhynchos) and common ravens (Corvus corax) in Canada...
April 19, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29672831/acute-effects-of-riluzole-and-retigabine-on-axonal-excitability-in-patients-with-als-a-randomized-double-blind-placebo-controlled-cross-over-trial
#3
Maria O Kovalchuk, Jules Aac Heuberger, Boudewijn Thm Sleutjes, Dimitrios Ziagkos, Leonard H van de Berg, Toby A Ferguson, Hessel Franssen, Geert Jan Groeneveld
Increased excitability of motor neurons in patients with amyotrophic lateral sclerosis may be a relevant factor leading to motor neuron damage. This randomized, double-blind, 3-way cross-over, placebo-controlled study evaluated peripheral motor nerve excitability-testing as biomarker of hyperexcitability and assessed effects of riluzole and retigabine in 18 patients with amyotrophic lateral sclerosis. We performed excitability-testing at baseline, and twice after participants had received a single dose of either 100mg riluzole, 300mg retigabine or placebo...
April 19, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29672176/prevalence-and-risk-factors-for-vascular-calcification-in-chinese-patients-receiving-dialysis-baseline-results-from-a-prospective-cohort-study
#4
Zhi-Hong Liu, Xue-Qing Yu, Jun-Wei Yang, Ai-Li Jiang, Bi-Cheng Liu, Chang-Ying Xing, Ji-Zhuang Lou, Mei Wang, Hong Cheng, Jun Liu, Jun-Zhou Fu, Ai-Hua Zhang, Miao Zhang, Qiao-Ling Zhou, Chen Yu, Rong Wang, Li Wang, Yu-Qing Chen, Tian-Jun Guan, Ai Peng, Chen Nan, Chuan-Ming Hao, Xu-Yang Cheng
OBJECTIVE: With limited data available on calcification prevalence in chronic kidney disease (CKD) patients on dialysis, the China Dialysis Calcification Study (CDCS) determined the prevalence of vascular/valvular calcification (VC) and association of risk factors in Chinese patients with prevalent hemodialysis (HD) or peritoneal dialysis (PD). METHODS: CKD patients undergoing HD/PD for ≥6 months were enrolled. Prevalence data for calcification and medical history were documented at baseline...
April 19, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29671920/who-said-dialogue-conversations-are-easy-the-communication-between-communication-vulnerable-people-and-health-care-professionals-a-qualitative-study
#5
Steffy E A Stans, Ruth J P Dalemans, Uta R Roentgen, Hester W H Smeets, Anna J H M Beurskens
OBJECTIVE: To gain insight into how communication vulnerable people and health-care professionals experience the communication in dialogue conversations, and how they adjust their conversation using augmentative and alternative communication (AAC) or other communication strategies. METHODS: Communication vulnerable clients and health-care professionals in a long-term care institution were observed during a dialogue conversation (n = 11) and subsequently interviewed (n = 22) about their experiences with the conversation...
April 19, 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29671712/detection-of-multi-drug-resistant-escherichia-coli-in-a-giant-panda-ailuropoda-melanoleuca-with-extraintestinal-polyinfection
#6
Wei Zhou, Lingwei Zhu, Min Jia, Tiecheng Wang, Bing Liang, Xue Ji, Yang Sun, Jun Liu, Xuejun Guo
Multi-drug-resistant Escherichia coli, Pseudomonas aeruginosa, and Enterococcus faecalis were isolated from the tissue samples of a giant panda. The E. coli strain SH-YH-DH that we isolated carried a self-transferable plasmid associated with multi-drug-resistant genes ( blaCTX-M-55 , blaTEM-1 , sul1, floR, strB, aac(6')-Ib, and tetA/R). This strain exhibited phenotypic resistance to gentamicin, cefotaxime, ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, and tetracycline. We report the participation of multi-drug-resistant E...
April 19, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29667528/speech-and-language-therapists-views-about-aac-system-acceptance-by-people-with-acquired-communication-disorders
#7
Eliada Pampoulou
OBJECTIVE: Some adults with acquired communication disorders are faced with an inability to communicate coherently through verbal speech with their communication partners. Despite the fact that a variety of augmentative and alternative communication (AAC) aided systems is available to assist them in communicating, not all adults accept them. In Cyprus, there is scant research focusing on the factors that are linked to AAC system acceptance and abandonment. METHODS: To address this gap, this research involves exploring the experiences of six speech and language therapists supporting adults with acquired communication disorders, who could benefit from the use of AAC systems...
April 18, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29666765/characterization-of-antimicrobial-resistance-genes-in-haemophilus-parasuis-isolated-from-pigs-in-china
#8
Yongda Zhao, Lili Guo, Jie Li, Xianhui Huang, Binghu Fang
Background: Haemophilus parasuis is a common porcine respiratory pathogen that causes high rates of morbidity and mortality in farmed swine. We performed a molecular characterization of antimicrobial resistance genes harbored by H. parasuis from pig farms in China. Methods: We screened 143 H. parasuis isolates for antimicrobial susceptibility against six fluoroquinolone antibiotics testing by the broth microdilution method, and the presence of 64 antimicrobial resistance genes by PCR amplification and DNA sequence analysis...
2018: PeerJ
https://www.readbyqxmd.com/read/29662886/high-prevalence-of-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-among-clinical-isolates-from-cats-and-dogs-admitted-to-a-veterinary-hospital-in-switzerland
#9
Anna Lena Zogg, Sabrina Simmen, Katrin Zurfluh, Roger Stephan, Sarah N Schmitt, Magdalena Nüesch-Inderbinen
Objectives: This study aimed to identify and characterize extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae among clinical samples of companion animals. Methods: A total of 346 non-duplicate Enterobacteriaceae isolates were collected between 2012 and 2016 from diseased cats ( n  = 115) and dogs ( n  = 231). The presence of bla ESBL , PMQR genes, and the azithromycin resistance gene mph(A) was confirmed by PCR and sequencing of bla genes...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29661878/plasticity-of-aminoglycoside-binding-to-antibiotic-kinase-aph-2-ia
#10
Shane J Caldwell, Albert M Berghuis
APH(2")-Ia aminoglycoside resistance enzyme forms the C-terminal domain of the bifunctional AAC(6')-Ie/APH(2")-Ia enzyme and confers high-level resistance to natural 4,6-disubstituted aminoglycosides. In addition, reports have suggested that the enzyme can phosphorylate 4,5-disubstituted compounds and aminoglycosides with substitutions at the N1-position. Previously determined structures of the enzyme with aminoglycosides bound have not indicated how these non-canonical substrates could bind and be modified by the enzyme...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29661042/identification-and-drawing-of-early-concepts-in-children-with-autism-spectrum-disorder-and-children-without-disability
#11
John W McCarthy, Joann P Benigno, Jamie Broach, Jamie B Boster, Bridget M Wright
This comparative study is a replication and extension of previous work related to children's drawings of early concepts. In all, 15 children with autism spectrum disorder (ASD) and 19 children without disability took part in the study, and were video recorded as they drew 10 early emerging concepts such as "eat" and "more." In a second task, the participants were asked to label Picture Communication Symbols conventionally used in augmentative and alternative communication (AAC) systems. Descriptive, correlational, and inferential statistics were used to analyze the data...
April 16, 2018: Augmentative and Alternative Communication: AAC
https://www.readbyqxmd.com/read/29655772/predicting-chronic-spontaneous-urticaria-symptom-return-after-omalizumab-treatment-discontinuation-exploratory-analysis
#12
Marta Ferrer, Ana Giménez-Arnau, Diego Saldana, Nico Janssens, Maria-Magdalena Balp, Sam Khalil, Valéry Risson
BACKGROUND: Omalizumab is highly effective in controlling chronic spontaneous urticaria (CSU) symptoms; however, patients can experience symptom return upon treatment discontinuation. Pivotal clinical trials have identified two categories of patients who experience symptom return: rapid and slow. OBJECTIVE: To identify potential predictors of the speed of symptom return after stopping omalizumab treatment. METHODS: Phase III randomized controlled trial (RCT) data from ASTERIA I (n=319; 6x4-weekly injections of omalizumab 75, 150, 300 mg or placebo; NCT01287117) and ASTERIA II (n=323; 3x4-weekly injections of omalizumab 75, 150, 300 mg or placebo; NCT01292473) were pooled to identify predictors of symptom return after stopping omalizumab treatment (16-week follow-up)...
April 12, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29649596/population-pharmacokinetics-and-pharmacodynamics-of-fosfomycin-in-non-critically-ill-patients-with-bacteremic-urinary-infection-caused-by-multidrug-resistant-escherichia-coli
#13
Vicente Merino-Bohorquez, Fernando Docobo-Pérez, Jesús Sojo, Isabel Morales, Carmen Lupión, Dolores Martín, Manuel Cameán, William Hope, Álvaro Pascual, Jesús Rodríguez-Baño
The aim of the present study was to describe the population pharmacokinetics of fosfomycin for patients with bacteraemic urinary tract infection (B-UTI). The analysis identified optimal regimens, based on pharmacodynamic targets and assessed the adequacy of CLSI and EUCAST susceptibility breakpoints for Escherchia coli. MethodsSixteen patients with B-UTI caused by multidrug-resistant E. coli, (FOREST clinical trial) received intravenous fosfomycin (4g/Q6h) were analysed. A population pharmacokinetic analysis was performed, and Monte Carlo simulations were undertaken using 4g/Q6h or 8g/Q8h...
April 9, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29642715/effects-of-dynamic-text-in-an-aac-app-on-sight-word-reading-for-individuals-with-autism-spectrum-disorder
#14
Jessica Caron, Janice Light, Christine Holyfield, David McNaughton
The purpose of this study was to investigate the effects of Transition to Literacy (T2L) software features (i.e., dynamic text and speech output upon selection of a graphic symbol) within a grid display in an augmentative and alternative communication (AAC) app, on the sight word reading skills of individuals with autism spectrum disorders (ASD) and complex communication needs. The study implemented a single-subject multiple probe research design across one set of three participants. The same design was utilized with an additional set of two participants...
April 12, 2018: Augmentative and Alternative Communication: AAC
https://www.readbyqxmd.com/read/29642712/methodological-advances-opportunities-and-challenges-in-aac-research
#15
Jennifer Kent-Walsh, Cathy Binger
Since its inception in 1985, the AAC journal has been publishing scientific articles related to the field of augmentative and alternative communication (AAC) that (a) report research concerning assessment, treatment, rehabilitation, and education of people who use or have the potential to use AAC systems and (b) cover theory, technology, and systems development relevant to AAC. The journal has maintained a consistent focus on the science and practice of AAC while also advancing in varied and impressive ways...
April 12, 2018: Augmentative and Alternative Communication: AAC
https://www.readbyqxmd.com/read/29627505/genome-analysis-of-urease-positive-serratia-marcescens-co-producing-srt-2-and-aac-6-ic-with-multidrug-efflux-pumps-for-antimicrobial-resistance
#16
Vijaya Bharathi Srinivasan, Govindan Rajamohan
In this study, we present the genome sequence of Serratia marcescens SM03, recovered from a human gut in India. The final assembly consists of 26 scaffolds (4620 coding DNA sequences, 5.08 Mb, 59.6% G + C ratio) and 79 tRNA genes. Analysis identified novel genes associated with lactose utilization, virulence, P-loop GTPases involved in urease production, CFA/I fimbriae apparatus and Yersinia - type CRISPR proteins. Antibiotic susceptibility testing indicated drug tolerant phenotype and inhibition assays demonstrated involvement of extrusion in resistance...
April 5, 2018: Genomics
https://www.readbyqxmd.com/read/29626008/differences-between-ata-aace-ace-ame-and-acr-ti-rads-ultrasound-classifications-performance-in-identifying-cytological-high-risk-thyroid-nodules
#17
Angelo Lauria, Ernesto Maddaloni, Silvia Irina Briganti, Giuseppina Beretta Anguissola, Eleonora Perrella, Chiara Taffon, Andrea Palermo, Paolo Pozzilli, Silvia Manfrini, Anna Crescenzi
OBJECTIVE: Thyroid ultrasound is crucial for clinical decision in the management of thyroid nodules. In this study we aimed to estimate and compare the performance of ATA, AACE/ACE/AME and ACR TI-RADS ultrasound classifications in discriminating nodules with high-risk cytology. DESIGN: Cross sectional study Methods 1077 thyroid nodules undergoing fine needle aspiration were classified according to ATA, AACE/ACE/AME and ACR TI-RADS ultrasound classifications by an automated algorithm...
April 6, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29622224/genetic-diversity-of-potato-genotypes-estimated-by-starch-physicochemical-properties-and-microsatellite-markers
#18
Sulaiman Ahmed, Xin Zhou, Yuehan Pang, Yanjie Xu, Chuan Tong, Jinsong Bao
Genetic diversity of 29 potato genotypes was estimated by their starch physicochemical properties and microsatellite markers. The apparent amylose content (AAC) of potato starches averaged 25.3%, ranging from 18.9 to 29.4%. Significance differences were observed in pasting and gel texture properties among potato accessions. Wide genetic diversity was also found in the gelatinization temperatures (To , Tp , Tc ), enthalpies of gelatinization, enthalpies of retrogradation and retrogradation percentage, which had ranges of 62...
August 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29614372/incidence-and-risk-of-co-transmission-of-plasmid-mediated-quinolone-resistance-and-extended-spectrum-%C3%AE-lactamase-genes-in-fluoroquinolone-resistant-uropathogenic-e-coli-a-first-study-from-kolkata-india
#19
Shreya Basu, Mandira Mukherjee
BACKGROUND: Co-resistance against fluroquinolone(FQ) and β-lactams cause treatment complications in infections caused by uropathogenic E.coli(UPEC).This study aims to detect coexistence and co-transmission of plasmid-mediated quinolone resistant(PMQR) and extended spectrum β-lactamases (ESBLs) in UPECs from Kolkata,India. METHODS: E. coli was detected biochemically from urine culture positive samples. Antibiotic resistance and ESBL production was confirmed by disk diffusion assay...
March 31, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29605334/characteristics-of-quinolone-resistant-escherichia-coli-isolated-from-bovine-mastitis-in-china
#20
Feng Yang, Shidong Zhang, Xiaofei Shang, Ling Wang, Hongsheng Li, Xurong Wang
Escherichia coli is the leading causative agent of bovine mastitis worldwide. Quinolone-resistant E. coli is becoming a potential threat to veterinary and public health. The aim of this study was to investigate the characteristics of quinolone-resistant E. coli isolated from bovine mastitis cases in China. Antimicrobial susceptibility of the isolates against 15 antimicrobial agents was determined by disc diffusion method. Phylogenetic grouping was detected by PCR. Extended-spectrum β-lactamase-producing isolates were determined by double-disc synergy test...
March 28, 2018: Journal of Dairy Science
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