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https://www.readbyqxmd.com/read/29443425/long-term-atherosclerotic-vascular-disease-risk-and-prognosis-in-elderly-women-with-abdominal-aortic-calcification-on-lateral-spine-images-captured-during-bone-density-testing-a-prospective-study
#1
Joshua R Lewis, John T Schousboe, Wai H Lim, Germaine Wong, Kevin E Wilson, Kun Zhu, Peter L Thompson, Douglas P Kiel, Richard L Prince
Lateral spine images are captured using bone densitometers for vertebral fracture assessment (VFA) in older women. Abdominal aortic calcification (AAC) is commonly seen on these images however the long-term prognosis in women with AAC remains uncertain. In a prospective study of 1,052 community-dwelling ambulant Caucasian women over 70 years AAC24 scores were calculated from digital lateral spine images captured during bone density testing in 1998 or 1999. Cardiovascular risk factors were assessed in 1998 while 14...
February 14, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29434938/genetic-characterization-and-in-vitro-activity-of-antimicrobial-combinations-of-multidrug-resistant-acinetobacter-baumannii-from-a-general-hospital-in-china
#2
Fang Chen, Ling Wang, Min Wang, Yixin Xie, Xiaomeng Xia, Xianping Li, Yanhua Liu, Wei Cao, Tingting Zhang, Pengling Li, Min Yang
The present study aimed to develop a rational therapy based on the genetic epidemiology, molecular mechanism evaluation and in vitro antibiotic combinations activity in multidrug-resistant Acinetobacter baumannii (MDRAB). MDRAB was screened by the Kirby-Bauer method. The random amplified polymorphic DNA technique was used to establish genetic fingerprinting, and a series of resistance genes were detected by polymerase chain reaction. Antimicrobial agents including amikacin (AK), cefoperazone/sulbactam (SCF I/II), meropenem (MEM), minocycline (MINO) and ciprofloxacin (CIP) were used to determine the minimum inhibitory concentrations (MICs) and interactions between antibiotics by the broth microdilution method and chequerboard assays...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433438/protective-effect-of-hydrogen-rich-saline-on-pressure-overload-induced-cardiac-hypertrophyin-rats-possible-role-of-jak-stat-signaling
#3
Zhixin Fan, Yufei Gao, Zhiwei Huang, Fenghua Xue, Shujing Wu, Jing Yang, Liqun Zhu, Lu Fu
BACKGROUND: Molecular hydrogen has been shown to have antioxidant effect and have been used to prevent oxidative stress-related diseases. The goal of this study was to explore if hydrogen-rich saline (HRS) plays a cardioprotective effect on abdominal aortic constriction (AAC) induced cardiac hypertrophy in rats. 60adult Sprague-Dawley rats received surgically the AAC for 6-week. After the surgery, the rats were randomly divided into 4 groups (15 for each):1: sham-operated (sham); 2: AAC-model; 3: AAC + Low HRS (LHRS); and 4: AAC + High HRS (HHRS)...
February 13, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29432938/first-report-on-antimicrobial-resistance-and-molecular-characterization-of-salmonella-enterica-serotype-typhi-isolated-from-human-specimens-in-luanda-angola
#4
Moisés Francisco, Sofia Santos Costa, Adriana Belas, Jorge Ramos, Isabel Couto, Constança Pomba, Miguel Viveiros
OBJECTIVES: Typhoid fever is a common infection in Africa and in spite of scarce surveillance reports, its incidence is commonly considered high by the Angolan Health system. Drug-resistant Salmonella enterica serotype Typhi has emerged, turning antimicrobial susceptibility testing essential to provide clinical guidance. This is the first report analyzing antimicrobial resistance patterns and population structure of the few S. enterica ser. Typhi isolated from patients with Typhoid fever in Luanda, Angola...
February 9, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29430885/abdominal-aortic-aneurysm-calcification-trying-to-identify-a-reliable-semiquantitative-method
#5
Marina Dias-Neto, Emmanuel Neves, Fábio Sousa-Nunes, Tiago Henriques-Coelho, Sérgio Sampaio
BACKGROUND: The main objective of this study was to assess the correlation between three semiquantitative and one computerized method based on Agatston Score (AS), when measuring abdominal aortic calcification (AAC) in abdominal aortic aneurysm (AAA) patients. Secondary aim was to access differences in AAC upon clinical variables, when different methods of calcium scoring are used. METHODS: This was an observational, retrospective, cross-sectional study. A database of AAA patients consecutively submitted to elective repair between 2008 and 2015 was used...
February 8, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29427764/identification-and-characterization-of-plasmid-mediated-quinolone-resistance-determinants-in-enterobacteriaceae-isolated-from-healthy-poultry-in-brazil
#6
Joseane Cristina Ferreira, Rafael Antonio Casarin Penha Filho, Ana Paula Yorika Kuaye, Leonardo Neves Andrade, Angelo Berchieri Junior, Ana Lúcia Costa Darini
The expression of plasmid-mediated quinolone resistance (PMQR) genes confers low-level quinolone and fluoroquinolones resistance alone. However, the association to chromosomal resistance mechanisms determines an expressively higher resistance in Enterobacteriaceae. These mechanisms are horizontally disseminated within plasmids and have contributed to the emergence of bacteria with reduced susceptibility or resistant to therapies worldwide. The epidemiological characterization of PMQR dissemination is highly relevant in the scientific and medical context, to investigate the dissemination within enterobacteria, from different populations, including humans and food-producing animals...
February 7, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29426916/2-methoxyestradiol-protects-against-pressure-overload-induced-left-ventricular-hypertrophy
#7
Zaid H Maayah, Jody Levasseur, Ramanaguru Siva Piragasam, Ghada Abdelhamid, Jason R B Dyck, Richard P Fahlman, Arno G Siraki, Ayman O S El-Kadi
Numerous experimental studies have supported the evidence that 2-methoxyestradiol (2 ME) is a biologically active metabolite that mediates multiple effects on the cardiovascular system, largely independent of the estrogen receptor. 2 ME is a major cytochrome P450 1B1 (CYP1B1) metabolite and has been reported to have vasoprotective and anti-inflammatory actions. However, whether 2 ME would prevent cardiac hypertrophy induced by abdominal aortic constriction (AAC) has not been investigated yet. Therefore, the overall objectives of the present study were to elucidate the potential antihypertrophic effect of 2 ME and explore the mechanism(s) involved...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29420133/distribution-of-antimicrobial-resistance-genes-and-class-1-integron-gene-cassette-arrays-in-motile-aeromonas-spp-isolated-from-goldfish-carassius-auratus
#8
Sabrina Hossain, Benthotage Chamara Jayasankha De Silva, Sudu Hakuruge Madusha Pramud Wimalasena, Hansani Nilupama Kumari Senarath Pathirana, Pasan Sepala Dahanayake, Gang-Joon Heo
Aeromonas spp. are opportunistic pathogens related to multiple infectious diseases in ornamental fishes. In the present study, the antimicrobial susceptibility, resistance genes, and integrons of 65 goldfish-borne Aeromonas spp. were evaluated. The isolates were identified as A. hydrophila (n = 30), A. veronii (n = 32), and A. punctata (n = 3) by gyrB sequencing. The antimicrobial susceptibility testing of the isolates designated that most of the isolates were resistant to amoxicillin (100.00%), nalidixic acid (100...
February 8, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29419922/transcriptome-profiles-of-sunflower-reveal-the-potential-role-of-microsatellites-in-gene-expression-divergence
#9
Chathurani Ranathunge, Gregory L Wheeler, Melody E Chimahusky, Meaghan M Kennedy, Jesse I Morrison, Brian S Baldwin, Andy D Perkins, Mark E Welch
The mechanisms by which natural populations generate adaptive genetic variation are not well understood. Some studies propose that microsatellites can function as drivers of adaptive variation. Here we tested a potentially adaptive role for transcribed microsatellites with natural populations of the common sunflower (Helianthus annuus L.) by assessing the enrichment of microsatellites in genes that show expression divergence across latitudes. Seeds collected from six populations at two distinct latitudes in Kansas and Oklahoma were planted and grown in a common garden...
February 8, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29414607/frequency-of-antimicrobial-resistance-and-integron-gene-cassettes-in-escherichia-coli-isolated-from-giant-pandas-ailuropoda-melanoleuca-in-china
#10
Wencheng Zou, Caiwu Li, Xin Yang, Yongxiang Wang, Guangyang Cheng, Jinxin Zeng, Xiuzhong Zhang, Yanpeng Chen, Run Cai, Qianru Huang, Lan Feng, Hongning Wang, Desheng Li, Guiquan Zhang, Yanxi Chen, Zhizhong Zhang, Heming Zhang
Escherichia coli (E. coli) is considered as a common opportunistic pathogen, which causes seriously intestinal infections to giant pandas (Ailuropoda melanoleuca) and other animals. The aim of this investigation was to characterize the antimicrobial resistance and integron gene cassettes in E. coli isolated from the faeces of giant pandas in China. A total of 89 E. coli were isolated, after diagnosis of isolates and genomes were extracted. All the isolates were screened for the presence of related drug-resistance genes and integron gene cassettes through the Polymerase Chain Reaction (PCR) and sequencing...
January 25, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29412179/high-frequency-spectral-ultrasound-imaging-susi-visualizes-early-post-traumatic-heterotopic-ossification-ho-in-a-mouse-model
#11
Kavitha Ranganathan, Xiaowei Hong, David Cholok, Joe Habbouche, Caitlin Priest, Christopher Breuler, Michael Chung, John Li, Arminder Kaura, Hsiao Hsin Sung Hsieh, Jonathan Butts, Serra Ucer, Ean Schwartz, Steven R Buchman, Jan P Stegemann, Cheri X Deng, Benjamin Levi
PURPOSE: Early treatment of heterotopic ossification (HO) is currently limited by delayed diagnosis due to limited visualization at early time points. In this study, we validate the use of spectral ultrasound imaging (SUSI) in an animal model to detect HO as early as one week after burn tenotomy. METHODS: Concurrent SUSI, micro CT, and histology at 1, 2, 4, and 9weeks post-injury were used to follow the progression of HO after an Achilles tenotomy and 30% total body surface area burn (n=3-5 limbs per time point)...
February 6, 2018: Bone
https://www.readbyqxmd.com/read/29410367/identification-of-a-small-molecule-inhibitor-of-the-aminoglycoside-6-n-acetyltransferase-type-ib-aac-6-ib-using-mixture-based-combinatorial-libraries
#12
Tung Tran, Kevin Chiem, Saumya Jani, Brock A Arivett, David L Lin, Rupali Lad, Verónica Jimenez, Mary B Farone, Ginamarie Debevec, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Marcelo E Tolmasky
The aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] is the most widely distributed enzyme among AAC(6')-I-producing Gram-negative pathogens and confers resistance to clinically relevant aminoglycosides including amikacin. This enzyme is therefore ideal to target with enzymatic inhibitors that could overcome resistance to aminoglycosides. The search for inhibitors was carried out using mixture-based combinatorial libraries, the scaffold ranking approach, and the positional scanning strategy. A library with high inhibitory activity had pyrrolidine pentamine scaffold and was selected for further analysis...
February 1, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29408952/predictive-value-of-malignancy-of-thyroid-nodule-ultrasound-classification-systems-a-prospective-study
#13
Agnese Persichetti, Enrico Di Stasio, Rinaldo Guglielmi, Giancarlo Bizzarri, Silvia Taccogna, Irene Misischi, Filomena Graziano, Lucilla Petrucci, Antonio Bianchini, Enrico Papini
Background: British Thyroid Association (BTA), American Thyroid Association (ATA) and American Association of Clinical Endocrinologists (AACE/ACE/AME) recommend for thyroid nodules an ultrasound (US)-based stratification of risk of malignancy. Aim of our study was to assess the diagnostic accuracy of US classification systems and their reliability for indication to fine-needle aspiration (FNA). Methods: Prospective study on 987 thyroid nodules consecutively referred for FNA...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29405547/abdominal-aortic-calcification-score-predicts-the-occurrence-of-coronary-artery-disease-in-middle-aged-peritoneal-dialysis-patients
#14
Hung-Chih Chen, Che-Yi Chou, Hsuan-Jen Lin, Chiu-Ching Huang, Chiz-Tzung Chang
BACKGROUND: Abdominal aortic calcification (AAC) score in dialysis patients was associated with coronary artery disease (CAD) in cross-sectional study, but the use of AAC score in the CAD occurrence prediction was not clear. We aimed to use AAC score in the estimation of CAD occurrence in middle-aged peritoneal dialysis (PD) patients. METHODS: Middle-aged (45-65 years old) PD patients were recruited and followed up until CAD occurrence, patient mortality, or PD failure...
February 5, 2018: Nephrology
https://www.readbyqxmd.com/read/29396344/prevalence-of-antibiotic-resistance-genes-in-bacteriophage-dna-fraction-from-funan-river-water-in-sichuan-china
#15
Yanxian Yang, Wenjin Shi, Shao-Yeh Lu, Jinxin Liu, Huihui Liang, Yifan Yang, Guowei Duan, Yunxia Li, Hongning Wang, Anyun Zhang
To better understand the role that bacteriophages play in antibiotic resistance genes (ARGs) dissemination in the aquatic environment, 36 water samples were collected from the Funan River in Sichuan, China. The occurrence of 15 clinically relevant ARGs and one class 1 integron gene int1 in phage-particle DNA were evaluated by PCR. The abundance of ARGs (blaCTX-M, sul1, and aac-(6')-1b-cr) was determined by quantitative PCR (qPCR). High prevalence of the int1 gene (66.7%) was found in the phage-particle DNA of tested samples, followed by sul1 (41...
January 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29391528/unravelling-genetic-variation-underlying-de-novo-synthesis-of-bovine-milk-fatty-acids
#16
Tim Martin Knutsen, Hanne Gro Olsen, Valeria Tafintseva, Morten Svendsen, Achim Kohler, Matthew Peter Kent, Sigbjørn Lien
The relative abundance of specific fatty acids in milk can be important for consumer health and manufacturing properties of dairy products. Understanding of genes controlling milk fat synthesis may contribute to the development of dairy products with high quality and nutritional value. This study aims to identify key genes and genetic variants affecting de novo synthesis of the short- and medium-chained fatty acids C4:0 to C14:0. A genome-wide association study using 609,361 SNP markers and 1,811 animals was performed to detect genomic regions affecting fatty acid levels...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29388780/copper-catalyzed-decarboxylative-click-cascade-reaction-regioselective-assembly-of-5-selenotriazole-anticancer-agents
#17
Fei-Hu Cui, Jing Chen, Zu-Yu Mo, Shi-Xia Su, Yan-Yan Chen, Xian-Li Ma, Hai-Tao Tang, Heng-Shan Wang, Ying-Ming Pan, Yan-Li Xu
A simple and efficient Cu-catalyzed decarboxylative/click reaction for the preparation of 1,4-disubstituted 5-arylselanyl-1,2,3-triazoles from propiolic acids, diselenides, and azides has been developed. The mechanistic study revealed that the intermolecular AAC reaction of an alkynyl selenium intermediate occurred. The resulting multisubstituted 5-seleno-1,2,3-triazoles were tested for in vitro anticancer activity by MTT assay, and compounds 4f, 4h, and 4p showed potent cancer cell-growth inhibition activities...
February 1, 2018: Organic Letters
https://www.readbyqxmd.com/read/29388433/annals-express-post-hoc-analysis-of-plasma-amino-acid-profiles-towards-a-specific-pattern-in-autism-spectrum-disorder-and-intellectual-disability
#18
Jean-Baptiste Delaye, Franck Patin, Emmanuelle Lagrue, Olivier Le Tilly, Clement Bruno, Marie-Laure Vuillaume, Martine Raynaud, Isabelle Benz-de Bretagne, Frederic Laumonnier, Patrick Vourc'h, Christian Andres, Helene Blasco
Objectives Autism Spectrum Disorders (ASD) and Intellectual Disability (ID) present a challenge for therapeutic and dietary management. We performed a re-analysis of plasma amino acid chromatography (AAC) of children with ASD (n=22) or ID (n=29) to search for a metabolic signature that can distinguish individuals with these disorders from controls (n=30). Methods We performed univariate and multivariate analysis using different machine learning strategies, from the raw data of the AAC. Finally, we analyzed the metabolic pathways associated with discriminant biomarkers...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29386304/abdominal-aortic-calcifications-predict-survival-in-peritoneal-dialysis-patients
#19
Satu M Mäkelä, Markku Asola, Henrik Hadimeri, James G Heaf, Maija Heiro, Leena Kauppila, Susanne Ljungman, Mai Ots-Rosenberg, Johan V Povlsen, Björn Rogland, Petra Roessel, Jana Uhlinova, Maarit Vainiotalo, Maria K Svensson, Heini Huhtala, Heikki Saha
BACKGROUND: Peripheral arterial disease and vascular calcifications contribute significantly to the outcome of dialysis patients. The aim of this study was to evaluate the prognostic role of severity of abdominal aortic calcifications and peripheral arterial disease on outcome of peritoneal dialysis (PD) patients using methods easily available in everyday clinical practice. METHODS: We enrolled 249 PD patients (mean age 61 years, 67% male) in this prospective, observational, multicenter study from 2009 to 2013...
January 31, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29385839/examining-sensory-ability-feature-matching-and-assessment-based-adaptation-for-a-brain-computer-interface-using-the-steady-state-visually-evoked-potential
#20
Jonathan S Brumberg, Anh Nguyen, Kevin M Pitt, Sean D Lorenz
PURPOSE: We investigated how overt visual attention and oculomotor control influence successful use of a visual feedback brain-computer interface (BCI) for accessing augmentative and alternative communication (AAC) devices in a heterogeneous population of individuals with profound neuromotor impairments. BCIs are often tested within a single patient population limiting generalization of results. This study focuses on examining individual sensory abilities with an eye toward possible interface adaptations to improve device performance...
January 31, 2018: Disability and Rehabilitation. Assistive Technology
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