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https://www.readbyqxmd.com/read/29236239/abdominal-aorta-and-pelvic-artery-calcifications-on-plain-radiographs-may-predict-mortality-in-chronic-kidney-disease-hemodialysis-and-renal-transplantation
#1
Sinee Disthabanchong, Kotcharat Vipattawat, Bunyong Phakdeekitcharoen, Chagriya Kitiyakara, Vasant Sumethkul
PURPOSE: Vascular calcification is common in chronic kidney disease (CKD) and predicts poor patient outcomes. While computed tomography is the gold standard for evaluation of vascular calcification, plain radiograph offers a simpler and less costly alternative. The calcification of abdominal aorta, iliac and femoral arteries has been evaluated by plain radiograph, but the data on their outcome predictabilities are still limited. The present study investigated the role of abdominal aortic calcification (AAC) and pelvic arterial calcification (PAC) in predicting overall morality in non-dialysis CKD stages 2-5 (CKD 2-5), maintenance hemodialysis (HD) and long-term kidney transplant (KT) patients...
December 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29234669/aminoglycoside-resistance-profile-and-structural-architecture-of-the-aminoglycoside-acetyltransferase-aac-6-im
#2
Clyde A Smith, Monolekha Bhattacharya, Marta Toth, Nichole K Stewart, Sergei B Vakulenko
Aminoglycoside 6'-acetyltransferase-Im (AAC(6')-Im) is the closest monofunctional homolog of the AAC(6')-Ie acetyltransferase of the bifunctional enzyme AAC(6')-Ie/APH(2")-Ia. The AAC(6')-Im acetyltransferase confers 4- to 64-fold higher MICs to 4,6-disubstituted aminoglycosides and the 4,5-disubstituted aminoglycoside neomycin than AAC(6')-Ie, yet unlike AAC(6')-Ie, the AAC(6')-Im enzyme does not confer resistance to the atypical aminoglycoside fortimicin. The structure of the kanamycin A complex of AAC(6')-Im shows that the substrate binds in a shallow positively-charged pocket, with the N6' amino group positioned appropriately for an efficient nucleophilic attack on an acetyl-CoA cofactor...
November 9, 2017: Microbial Cell
https://www.readbyqxmd.com/read/29229634/genomic-insights-into-colistin-resistant-klebsiella-pneumoniae-from-a-tunisian-teaching-hospital
#3
Nadia Jaidane, Rémy A Bonnin, Wejdene Mansour, Delphine Girlich, Elodie Creton, Garance Colleton, Cherifa Chaouch, Noureddine Boujaafar, Olfa Bouallegue, Thierry Naas
The emergence of colistin-resistant Klebsiella pneumoniae (CoRKp) is a public health concern since this antibiotic has become the last line of treatment for infections caused by multidrug-resistant (MDR) gram-negatives. In this study, we have investigated the molecular basis of colistin-resistance in 13 MDR Kp isolated from 12 patients in a teaching hospital in Sousse, Tunisia. Whole-genome sequencing (WGS) was used to decipher the molecular mechanism of colistin-resistance and to identify the resistome of these CoRKp It revealed a genome of ca...
December 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29228915/qualitative-and-quantitative-evaluation-of-acute-angle-closure-mechanisms
#4
Yanin Suwan, Sunpong Jiamsawad, Apichat Tantraworasin, Lawrence Geyman, Wasu Supakontanasan, Chaiwat Teekhasaenee
BACKGROUND: To evaluate ocular biometric parameters in different subtypes of acute angle closure and compared to fellow eyes of AAC and PACS eyes. METHODS: This is a retrospective chart review study. A total of 167 eyes (96 patients) consisting of 71 AAC eyes, 71 fellow eyes of AAC, and 25 PACS eyes were recruited. All patients underwent ocular examination and biometry. The mechanism of AAC was confirmed by ultrasound biomicroscopy. We then subdivided AAC eyes into four subgroups: crowded-angle (CR), lens subluxation (LS) pupillary block (PB), and plateau iris syndrome (PL)...
December 11, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29227186/diversity-of-ctx-m-extended-spectrum-%C3%AE-lactamases-in-escherichia-coli-isolates-from-retail-raw-ground-beef-first-report-of-ctx-m-24-and-ctx-m-32-in-algeria
#5
Nesrine Rebbah, Yamina Messai, Pierre Châtre, Marisa Haenni, Jean Yves Madec, Rabah Bakour
The aim of this study was to investigate the prevalence and molecular features of extended-spectrum cephalosporin resistance in Escherichia coli isolates contaminating ground beef at retail in Algeria. Of 371 ground beef samples, 27.5% were found to contain cefotaxime-resistant E. coli isolates distributed into A (24.5%), B1 (60.8%), and D (14.7%) phylogroups. A rate of 88.2% of isolates had a multidrug-resistance phenotype. All strains were producers of CTX-M type extended-spectrum β-lactamases (ESBLs): CTX-M-1, CTX-M-3, CTX-M-14, CTX-M-15, CTX-M-24, or CTX-M-32...
December 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29226702/extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-in-wastewaters-and-refugee-camp-in-lebanon
#6
Sima Tokajian, Rima Moghnieh, Tamara Salloum, Harout Arabaghian, Sahar Alousi, Jennifer Moussa, Edmond Abboud, Souad Youssef, Rola Husni
AIM: To evaluate the effects of population influx of refugees on the prevalence of extended-spectrum β-lactamase-producing Escherichia coli in wastewater networks in Lebanon. MATERIALS & METHODS: Pulsed-field gel electrophoresis, multilocus sequence typing and antibiotic resistance genes typing were performed. RESULTS: 53.1% of isolates recovered from Al-Qaa refugee camp were positive for the tested resistant determinants compared with 49...
December 11, 2017: Future Microbiology
https://www.readbyqxmd.com/read/29224710/spm-1-producing-pseudomonas-aeruginosa-st277-clone-recovered-from-microbiota-of-migratory-birds
#7
Willames M B S Martins, Ana Clara Narciso, Rodrigo Cayô, Stéfanie Vanessa Santos, Lorena C C Fehlberg, Patrícia Locosque Ramos, João Batista da Cruz, Ana Cristina Gales
The production of São Paulo metallo-β-lactamase (SPM-1) is the most common carbapenem resistance mechanism detected among multidrug-resistant Pseudomonas aeruginosa clinical isolates in Brazil. Dissemination of SPM-1-producing P. aeruginosa has been restricted to the nosocomial settings, with sporadic reports of environmental isolates due to contamination by hospital sewage. Herein, we described the detection and molecular characterization of SPM-1-producing P. aeruginosa recovered from the microbiota of migratory birds in Brazil...
November 10, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29217202/cell-free-production-purification-and-characterization-of-human-mitochondrial-adp-atp-carriers
#8
Aleksandra Woznicka-Misaila, Céline Juillan-Binard, Delphine Baud, Eva Pebay-Peyroula, Stéphanie Ravaud
Mitochondrial Carriers (MCs) are responsible for fluent traffic of a variety of compounds that need to be shuttled via mitochondrial inner membranes to maintain cell metabolism. The ADP/ATP Carriers (AACs) are responsible for the import of ADP inside the mitochondria and the export of newly synthesized ATP. In human, four different AACs isoforms are described which are expressed in tissue-specific manner. They are involved in different genetic diseases and play a role in cancerogenesis. Up to now only the structures of the bovine (isoform 1) and yeast (isoforms 2 and 3) AAC have been determined in one particular conformation, obtained in complex with the CATR inhibitor...
December 4, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/29211900/racial-ethnic-differences-in-the-epidemiology-of-ovarian-cancer-a-pooled-analysis-of-12-case-control-studies
#9
Lauren C Peres, Harvey Risch, Kathryn L Terry, Penelope M Webb, Marc T Goodman, Anna H Wu, Anthony J Alberg, Elisa V Bandera, Jill Barnholtz-Sloan, Melissa L Bondy, Michele L Cote, Ellen Funkhouser, Patricia G Moorman, Edward S Peters, Ann G Schwartz, Paul D Terry, Ani Manichaikul, Sarah E Abbott, Fabian Camacho, Susan J Jordan, Christina M Nagle, Mary Anne Rossing, Jennifer A Doherty, Francesmary Modugno, Kirsten Moysich, Roberta Ness, Andrew Berchuck, Linda Cook, Nhu Le, Angela Brooks-Wilson, Weiva Sieh, Alice Whittemore, Valerie McGuire, Joseph Rothstein, Hoda Anton-Culver, Argyrios Ziogas, Celeste L Pearce, Chiuchen Tseng, Malcom Pike, Joellen M Schildkraut
Background: Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC) to examine racial/ethnic differences in epidemiological characteristics with suspected involvement in epithelial ovarian cancer (EOC) aetiology. Methods: We used multivariable logistic regression to estimate associations for 17 reproductive, hormonal and lifestyle characteristics and EOC risk by race/ethnicity among 10 924 women with invasive EOC (8918 Non-Hispanic Whites, 433 Hispanics, 911 Blacks, 662 Asian/Pacific Islanders) and 16 150 controls (13 619 Non-Hispanic Whites, 533 Hispanics, 1233 Blacks, 765 Asian/Pacific Islanders)...
December 2, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29209306/ctx-m-15-producing-e-coli-isolates-from-food-products-in-germany-are-mainly-associated-with-an-incf-type-plasmid-and-belong-to-two-predominant-clonal-e-coli-lineages
#10
Alexandra Irrgang, Linda Falgenhauer, Jennie Fischer, Hiren Ghosh, Elisabet Guiral, Beatriz Guerra, Silvia Schmoger, Can Imirzalioglu, Trinad Chakraborty, Jens A Hammerl, Annemarie Käsbohrer
Extended-spectrum beta-lactamases (ESBL) mediating resistance to 3rd generation cephalosporins are a major public health issue. As food may be a vehicle in the spread of ESLB-producing bacteria, a study on the occurrence of cephalosporin-resistantu Escherichia coli in food was initiated. A total of 404 ESBL-producing isolates were obtained from animal-derived food samples (e.g., poultry products, pork, beef and raw milk) between 2011 and 2013. As CTX-M-15 is the most abundant enzyme in ESBL-producing E. coli causing human infections, this study focusses on E...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29205073/effects-of-citronella-oil-cymbopogon-winterianus-jowitt-ex-bor-on-spodoptera-frugiperda-j-e-smith-midgut-and-fat-body
#11
Cts Silva, V Wanderley-Teixeira, F M Cunha, J V Oliveira, K A Dutra, Dma Ferraz Navarro, Aac Teixeira
The armyworm, Spodoptera frugiperda, is the principal pest of corn in Brazil. Control is achieved primarily by synthetic insecticides, which cause problems for the agro-ecosystem. Alternative methods of control are under investigation and citronella (Cymbopogon winterianus) essential oil appears to be a promising agent. We investigated the effects of citronella oil using histological, histochemical and immunohistochemical methods. The midgut of larvae treated with citronella exhibited altered epithelium including cytoplasmic protrusions, columnar cell extrusion, pyknotic nuclei, and increased periodic acid-Schiff positive granules...
December 5, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29205054/best-practices-protocol-for-the-evaluation-of-bulbar-dysfunction-summary-recommendations-from-the-neals-bulbar-subcommittee-symposium
#12
Gary L Pattee, Emily K Plowman, Benjamin R Brooks, James D Berry, Nazem Atassi, Jennifer L Chapin, Kendrea Garand, Yana Yunusova, Courtney E Mcilduff, Eufrosina Young, John M Costello, Eric A Macklin, Eduardo R Locatelli, Vincenzo Silani, Daragh Heitzman, James Wymer, Stephen A Goutman, Deborah F Gelinas, Richard Smith, Bridget Perry, Paige Nalipinski, Kaila Stipancic, Meghan O'Brien, Stacey L Sullivan, Jordan Green
OBJECTIVE: The aim of this Symposium was to develop a consensus based, bulbar assessment protocol for implementation within NEALS clinics. METHODS: A one-day symposium, held in April 2017, was organized into Speech and Swallowing sections to establish summary recommendations for the assessment of bulbar dysfunction within each group. RESULTS: Summary recommendations included speech referrals and AAC evaluations at initial visit, CNS-BFS, maximum sustained phonation, and speaking rate...
December 5, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29203841/asymmetric-adiabatic-couplers-for-fully-integrated-broadband-quantum-polarization-state-preparation
#13
Hung-Pin Chung, Kuang-Hsu Huang, Kai Wang, Sung-Lin Yang, Shih-Yuan Yang, Chun-I Sung, Alexander S Solntsev, Andrey A Sukhorukov, Dragomir N Neshev, Yen-Hung Chen
Spontaneous parametric down-conversion (SPDC) is a widely used method to generate entangled photons, enabling a range of applications from secure communication to tests of quantum physics. Integrating SPDC on a chip provides interferometric stability, allows to reduce a physical footprint, and opens a pathway to true scalability. However, dealing with different photon polarizations and wavelengths on a chip presents a number of challenging problems. In this work, we demonstrate an on-chip polarization beam-splitter based on z-cut titanium-diffused lithium niobate asymmetric adiabatic couplers (AAC) designed for integration with a type-II SPDC source...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29196301/interobserver-agreement-of-various-thyroid-imaging-reporting-and-data-systems
#14
Giorgio Grani, Livia Lamartina, Vito Cantisani, Marianna Maranghi, Piernatale Lucia, Cosimo Durante
Ultrasonography is the best available tool for the initial work-up of thyroid nodules. Substantial interobserver variability has been documented in the recognition and reporting of some of the lesion characteristics. A number of classification systems have been developed to estimate the likelihood of malignancy: several of them have been endorsed by scientific societies, but their reproducibility has yet to be assessed. We evaluated the interobserver variability of the AACE/ACE/AME, ACR, ATA, EU-TIRADS, and K-TIRADS classification systems and the interobserver concordance in the indication to FNA biopsy...
December 1, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29190135/aace-ace-position-statement-on-the-use-of-follow-on-biologics-and-biosimilars-for-endocrine-diseases
#15
Vivian A Fonseca, Zachary T Bloomgarden, Samuel Dagogo-Jack, George Grunberger, Daniel Einhorn, Alan J Garber, Yehuda Handelsman, Irl B Hirsch, Guillermo E Umpierrez
This document represents the official position of the American Association of Clinical Endocrinologists and American College of Endocrinology. Where there were no randomized controlled trials or specific U.S. FDA labeling for issues in clinical practice, the participating clinical experts utilized their judgment and experience. Every effort was made to achieve consensus among the committee members. Position and consensus statements are meant to provide guidance, but they are not to be considered prescriptive for any individual patient and cannot replace the judgment of a clinician...
November 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29184366/polymerase-chain-reaction-detection-of-genes-responsible-for-multiple-antibiotic-resistance-staphylococcus-aureus-isolated-from-food-of-animal-origin-in-egypt
#16
Fawzy R El Seedy, A A Samy, Hala S H Salam, Eman A Khairy, Aya A Koraney
Aim: The aim of our study was polymerase chain reaction (PCR) detection of the genes responsible for the multiple antibiotic resistance S. aureus isolated from food of animal origin in Egypt. Materials and Methods: A total of 125 samples were randomly collected from milk, meat, and their products from Giza and Beni-Suef Governorates markets. The S. aureus isolates were subjected to antimicrobial sensitivity tests using four antibacterial disks (Oxoid), and then the polymerase chain reaction (PCR) was performed for detection of antibiotic resistance genes...
October 2017: Veterinary World
https://www.readbyqxmd.com/read/29170451/chemokines-protect-vascular-smooth-muscle-cells-from-cell-death-induced-by-cyclic-mechanical-stretch
#17
Jing Zhao, Yuhei Nishimura, Akihiko Kimura, Kentaro Ozawa, Toshikazu Kondo, Toshio Tanaka, Masanori Yoshizumi
The pulsatile nature of blood flow exposes vascular smooth muscle cells (VSMCs) in the vessel wall to cyclic mechanical stretch (CMS), which evokes VSMC proliferation, cell death, phenotypic switching, and migration, leading to vascular remodeling. These responses have been observed in many cardiovascular diseases; however, the underlying mechanisms remain unclear. We have revealed that CMS of rat aortic smooth muscle cells (RASMCs) causes JNK- and p38-dependent cell death and that a calcium channel blocker and angiotensin II receptor antagonist decreased the phosphorylation of JNK and p38 and subsequently decreased cell death by CMS...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29169020/biomarkers-of-antibiotic-resistance-genes-during-seasonal-changes-in-wastewater-treatment-systems
#18
Ya-Nan Jiao, Zhen-Chao Zhou, Tao Chen, Yuan-Yuan Wei, Ji Zheng, Rui-Xia Gao, Hong Chen
To evaluate the seasonal distribution of antibiotic resistance genes (ARGs) and explore the reason for their patterns in different seasons and different systems, two wastewater treatment systems were selected and analyzed using high-throughput qPCR. Linear discriminant analysis (LDA) effect size (LEfSe) was used to discover the differential ARGs (biomarkers) and estimate the biomarkers' effect size. We found that the total absolute abundances of ARGs in inflows and excess sludge samples had no obvious seasonal fluctuations, while those in winter outflow samples decreased in comparison with the inflow samples...
November 20, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29168268/lifetime-marijuana-use-and-subclinical-atherosclerosis-the-coronary-artery-risk-development-in-young-adults-cardia-study
#19
Reto Auer, Stephen Sidney, David Goff, Eric Vittinghoff, Mark J Pletcher, Norrina B Allen, Jared P Reis, Cora E Lewis, Jeffrey Carr, Jamal S Rana
BACKGROUND AND AIMS: Unlike tobacco, the effect of marijuana smoke on subclinical atherosclerosis, a surrogate measure for cardiovascular disease, is not known. This study aimed to determine the association between lifetime exposure to marijuana and measures of subclinical atherosclerosis in mid-life. DESIGN, SETTING AND PARTICIPANTS: We used data from the US-based Coronary Artery Risk Development in Young Adults (CARDIA) Study, a cohort of black and white men and women aged 18-30 years at baseline in 1985-86, with up to 7 follow-up exams over 25 years...
November 22, 2017: Addiction
https://www.readbyqxmd.com/read/29160428/plasmid-mediated-mcr-1-in-carbapenem-susceptible-escherichia-coli-st156-causing-a-blood-infection-an-unnoticeable-spread-of-colistin-resistance-in-brazil
#20
Flavia Rossi, Raquel Girardello, Carlos Morais, Ana Paula Cury, Layla Farage Martins, Aline Maria da Silva, Edson Abdala, João Carlos Setubal, Alberto José da Silva Duarte
OBJECTIVE: We describe an IncX4 pHC891/16mcr plasmid carrying mcr-1 in a colistin-resistant and carbapenem-susceptible E. coli isolate (HC891/16), ST156, which caused a blood infection in a Brazilian patient with gallbladder adenocarcinoma. METHODS: Strain HC891/16 was subjected to whole genome sequencing using the MiSeq Platform (Illumina, Inc., USA). Assembly was performed using Mira and ABACAS. RESULTS: The isolates showed resistance only to ciprofloxacin, ampicillin and cefoxitin, and whole-genome sequencing revealed the presence of aac(6')Ib-cr and blaTEM1...
October 2017: Clinics
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