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https://www.readbyqxmd.com/read/28820112/prevalence-study-of-plasmid-mediated-ampc-%C3%AE-lactamases-in-enterobacteriaceae-lacking-inducible-ampc-from-saudi-hospitals
#1
Baha Abdalhamid, Samar Albunayan, Alaa Shaikh, Nasreldin Elhadi, Reem Aljindan
PURPOSE: Enterobacteriaceae encoding plasmid-mediated AmpC (pAmpC) β-lactamases confer resistance to the third generation cephalosporins. pAmpC association with extended spectrum β-lactamases (ESBLs), plasmid-mediated quinolone resistance (PMQR) and aminoglycoside modifying enzymes (AMEs) is well documented. There are limited data regarding the epidemiology and clinical significance of pAmpC in Saudi Arabia. This study aimed to determine the prevalence of pAmpC and its coexistence with ESBLs, PMQR and AMEs in Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis isolates in Saudi hospitals from January to December 2015...
August 18, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28813691/effects-of-superabsorbent-polymers-on-the-abundances-of-antibiotic-resistance-genes-mobile-genetic-elements-and-the-bacterial-community-during-swine-manure-composting
#2
Aiyun Guo, Jie Gu, Xiaojuan Wang, Ranran Zhang, Yanan Yin, Wei Sun, Xiaxia Tuo, Li Zhang
Superabsorbent polymers (SAPs) are considered suitable amendments for reducing the selection pressure due to heavy metals and the abundances of antibiotic resistance genes (ARGs) during composting. In this study, three SAP (sodium polyacrylate) levels (0, 5, and 15mgkg(-1) of compost) were applied and their effects on the abundances of ARGs, mobile genetic elements (MGEs), and the bacterial community were investigated. After composting, the abundances of ARGs and MGEs decreased to different extent, where the removal efficiencies for tetW, dfrA7, ermX, aac(6')-ib-cr and MGEs exceeded 90%...
August 5, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28812297/neomycin-biosynthesis-is-regulated-positively-by-afsa-g-and-neor-in-streptomyces-fradiae-cgmcc-4-7387
#3
Xiangxi Meng, Wenzhao Wang, Zhoujie Xie, Pengwei Li, Yue Li, Zhengyan Guo, Yingjian Lu, Jie Yang, Kaile Guan, Zhaoxin Lu, Huarong Tan, Yihua Chen
Neomycins are a group of aminoglycoside antibiotics with both clinical and agricultural applications. To elucidate the regulatory mechanism of neomycin biosynthesis, we completed draft genome sequencing of a neomycin producer Streptomyces fradiae CGMCC 4.7387 from marine sediments, and the neomycin biosynthesis gene cluster was identified. Inactivation of the afsA-g gene encoding a γ-butyrolactone (GBL) synthase in S. fradiae CGMCC 4.7387 resulted in a significant decrease of neomycin production. Quantitative RT-PCR analysis revealed that the transcriptional level of neoR and the aphA-neoGH operon were reduced in the afsA-g::aac(3)IV mutant...
August 14, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28809485/dispersion-and-halogen-bonding-interactions-binding-of-the-axial-conformers-of-monohalo-and-%C3%A2-trans-1-2-dihalocyclohexanes-in-enantiopure-alleno-acetylenic-cages
#4
Cornelius Gropp, Tamara Husch, Nils Trapp, Markus Reiher, François Diederich
Enantiopure alleno-acetylenic cage (AAC) receptors with a resorcin[4]arene scaffold, from which four homochiral alleno-acetylenes converge to shape a cavity closed by a four-fold OH-hydrogen-bonding array, form a highly ordered porous network in the solid state. They enable the complexation and co-crystallization of otherwise non-crystalline small molecules. This paper analyzes the axial conformers of monohalo- and (±)-trans-1,2-dihalocyclohexanes, bound in the interior cavity of the AACs, on the atomic level in the solid state and in solution, accompanied by accurate calculations...
August 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28805537/high-prevalence-of-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-in-wild-fish-from-the-mediterranean-sea-in-algeria
#5
Soumia Brahmi, Abdelaziz Touati, Catherine Dunyach-Remy, Albert Sotto, Alix Pantel, Jean-Philippe Lavigne
AIM: We investigated the prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae among wild fish from the coast of Bejaia (Algeria) in the Mediterranean Sea. RESULTS: From March 2012 to August 2013, gut and gill samples of wild fish were screened for the presence of ESBL-producing Enterobacteriaceae. Strains were characterized with regard to antibiotic resistance, β-lactamase content, plasmid-mediated quinolone resistance, aminoglycoside resistance genes, and clonality (repetitive sequence-based polymerase chain reaction profiles and multilocus sequence typing)...
August 14, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28803549/comparative-gut-microbiota-and-resistome-profiling-of-intensive-care-patients-receiving-selective-digestive-tract-decontamination-and-healthy-subjects
#6
Elena Buelow, Teresita D J Bello González, Susana Fuentes, Wouter A A de Steenhuijsen Piters, Leo Lahti, Jumamurat R Bayjanov, Eline A M Majoor, Johanna C Braat, Maaike S M van Mourik, Evelien A N Oostdijk, Rob J L Willems, Marc J M Bonten, Mark W J van Passel, Hauke Smidt, Willem van Schaik
BACKGROUND: The gut microbiota is a reservoir of opportunistic pathogens that can cause life-threatening infections in critically ill patients during their stay in an intensive care unit (ICU). To suppress gut colonization with opportunistic pathogens, a prophylactic antibiotic regimen, termed "selective decontamination of the digestive tract" (SDD), is used in some countries where it improves clinical outcome in ICU patients. Yet, the impact of ICU hospitalization and SDD on the gut microbiota remains largely unknown...
August 14, 2017: Microbiome
https://www.readbyqxmd.com/read/28800411/antimicrobial-resistance-and-resistance-genes-in-salmonella-strains-isolated-from-broiler-chickens-along-the-slaughtering-process-in-china
#7
Yuanting Zhu, Haimei Lai, Likou Zou, Sheng Yin, Chengtao Wang, Xinfeng Han, Xiaolong Xia, Kaidi Hu, Li He, Kang Zhou, Shujuan Chen, Xiaolin Ao, Shuliang Liu
A total of 189 Salmonella isolates were recovered from 627 samples which were collected from cecal contents of broilers, chicken carcasses, chicken meat after cutting step and frozen broiler chicken products along the slaughtering process at a slaughterhouse in Sichuan province of China. The Salmonella isolates were subjected to antimicrobial susceptibility testing to 10 categories of antimicrobial agents using the Kirby-Bauer disk diffusion method. Those antibiotics-resistant isolates were further investigated for the occurrence of resistance genes, the presence of class 1 integron as well as the associated gene cassettes, and the mutations within the gyrA and parC genes...
August 1, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28794074/the-incidence-of-acute-angle-closure-in-scotland-a-prospective-surveillance-study
#8
Paul Y Chua, Alexander C Day, Ken L Lai, Nikki Hall, Lai L Tan, Kamran Khan, Lik Thai Lim, Barny Foot, Paul J Foster, Augusto Azuara-Blanco
PURPOSE: To estimate the incidence, and describe the clinical features and short-term clinical outcomes of acute angle closure (AAC). METHODS: Patients with newly diagnosed AAC were identified prospectively over a 12-month period (November 2011 to October 2012) by active surveillance through the Scottish Ophthalmic Surveillance Unit reporting system. Data were collected at case identification and at 6 months follow-up. RESULTS: There were 114 cases (108 patients) reported, giving an annual incidence of 2...
August 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28793160/language-samples-from-children-who-use-speech-generating-devices-making-sense-of-small-samples-and-utterance-length
#9
Thomas Kovacs, Katya Hill
Purpose: Mean length of utterance in morphemes (MLUm) is underreported in people who use augmentative and alternative communication (AAC). MLUm is difficult to measure in people who use AAC because of 2 challenges described in literature: the challenge of small language samples (difficulty collecting representative samples) and the challenge of transcribing short utterances (difficulty transcribing 1-morpheme utterances). We tested solutions to both challenges in a corpus of language samples from children who use speech-generating devices...
August 15, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28783443/a-new-style-for-synthesis-of-thermo-responsive-fe3o4-poly-methylmethacrylate-b-n-isopropylacrylamide-b-acrylic-acid-magnetic-composite-nanosphere-and-theranostic-applications
#10
Aliyeh Ghamkhari, Bakhshali Massoumi, Roya Salehi
In this work,a novelthermo-responsive Fe3O4/poly(methylmethacrylate-b-N-isopropylacrylamide-b-acrylic acid) magnetic composite nanospherewas synthesized for anticancer drug delivery applications. For this propose, the poly(methylmethacrylate-b-N-isopropylacrylamide-b-acrylicacid) [poly(MMA-b-NIPAAm-b-AAc)] was synthesizedviareversible addition-fragmentation transfer (RAFT)method.The physic-chemical characterization of the Fe3O4/poly(MMA-b-NIPAAm-b-AAc) magnetic composite nanosphere was investigated by FTIR, HNMRspectroscopies and GPC,FESEM, XRD, VSM andDLS...
August 7, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28782142/influence-of-gestational-diabetes-on-the-fetal-autonomic-nervous-system-a-study-using-phase-rectified-signal-averaging-analysis
#11
Silvia M Lobmaier, Javier U Ortiz, Maria Sewald, Alexander Müller, Georg Schmidt, Bernhard Haller, Renate Oberhoffer, Karl T M Schneider, Dino A Giussani, Annette Wacker-Gußmann
OBJECTIVES: Maternal gestational diabetes (GDM) is known to influence fetal physiology. Phase-rectified signal averaging (PRSA), an innovative signal processing technique, can be used to investigate signals obtained from fetal heart. The PRSA calculated variables "average acceleration capacity" (AAC) and "average deceleration capacity" (ADC) are established indices of autonomic nervous system (ANS) function. The aim of this study was to evaluate the influence of gestational diabetes on the fetal ANS in human pregnancy using PRSA...
August 7, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28774859/conjugal-transfer-of-aac-6-ie-aph-2%C3%A2-ia-gene-from-native-species-and-mechanism-of-regulation-and-cross-resistance-in-enterococcus-faecalis-mcc3063-by-real-time-pcr
#12
G Jaimee, P M Halami
High level aminoglycoside resistance (HLAR) in the lactic acid bacteria (LAB) derived from food animals is detrimental. The aim of this study was to investigate the localization and conjugal transfer of aminoglycoside resistance genes, aac(6')Ie-aph(2″)Ia and aph(3')IIIa in different Enterococcus species. The cross resistance patterns in Enterococcus faecalis MCC3063 to clinically important aminoglycosides by real time PCR were also studied. Southern hybridization experiments revealed the presence of aac(6')Ie-aph(2(″))Ia and aph(3')IIIa genes conferring HLAR in high molecular weight plasmids except in Lactobacillus plantarum...
July 31, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28773861/experimental-study-on-full-scale-beams-made-by-reinforced-alkali-activated-concrete-undergoing-flexure
#13
Linda Monfardini, Fausto Minelli
Alkali Activated Concrete (AAC) is an alternative kind of concrete that uses fly ash as a total replacement of Portland cement. Fly ash combined with alkaline solution and cured at high temperature reacts to form a binder. Four point bending tests on two full scale beams made with AAC are described in this paper. Companion small material specimens were also casted with the aim of properly characterizing this new tailored material. The beam's length was 5000 mm and the cross section was 200 mm × 300 mm. The AAC consisted of fly ash, water, sand 0-4 mm and coarse aggregate 6-10 mm; and the alkaline solution consisted of sodium hydroxide mixed with sodium silicate...
August 30, 2016: Materials
https://www.readbyqxmd.com/read/28763677/genetic-basis-of-enzymatic-resistance-of-e-coli-to-aminoglycosides
#14
Dominika Ojdana, Anna Sieńko, Paweł Sacha, Piotr Majewski, Piotr Wieczorek, Anna Wieczorek, Elżbieta Tryniszewska
PURPOSE: Over the past years, an increase in resistance to aminoglycosides has been observed among Enterobacteriaceae rods. This resistance development reduces therapeutic options for infections caused by multidrug-resistance organisms. Because of the changing epidemiology of extended-spectrum β-lactamases (ESBLs) and resistance to aminoglycosides, we investigated the prevalence of the aac(3)-Ia, aac(6')-Ib, ant(4')-IIa, ant(2")-Ia, and aph(3")-Ib genes encoding aminoglycoside-modifying enzymes (AMEs) in ESBL-producing Escherichia coli as well as ESBL-non-producing isolates...
July 29, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28756664/structural-and-functional-survey-of-environmental-aminoglycoside-acetyltransferases-reveals-functionality-of-resistance-enzymes
#15
Zhiyu Xu, Peter J Stogios, Andrew T Quaile, Kevin J Forsberg, Sanket Patel, Tatiana Skarina, Scott Houliston, Cheryl Arrowsmith, Gautam Dantas, Alexei Savchenko
Aminoglycoside N-acetyltransferases (AACs) confer resistance against the clinical use of aminoglycoside antibiotics. The origin of AACs can be traced to environmental microbial species representing a vast reservoir for new and emerging resistance enzymes, which are currently undercharacterized. Here, we performed detailed structural characterization and functional analyses of four metagenomic AAC (meta-AACs) enzymes recently identified in a survey of agricultural and grassland soil microbiomes ( Forsberg et al...
August 16, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28750365/a-novel-evaluation-for-predicting-aortic-complicated-lesions-using-calcification-on-chest-x-ray
#16
Yoshitaka Yamaguchi, Tomotaka Tanaka, Sohei Yoshimura, Masatoshi Koga, Kazuyuki Nagatsuka, Kazunori Toyoda
BACKGROUND: The aorta is a significant source of cerebral thromboembolisms. Aortic complicated lesions (ACLs) are key findings on transesophageal echocardiography (TEE) for assessing aortic sources of emboli to the brain. TEE is sometimes avoided due to its invasiveness. However, few reports have examined alternative methods for predicting ACLs. We investigated relationships between aortic arch calcification (AAC) on chest X-ray and ACLs. METHODS: Participants comprised 300 patients with acute ischemic stroke or transient ischemic attack who underwent TEE for the evaluation of the aortic arch and heart...
July 28, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28748891/study-of-chronic-kidney-disease-mineral-bone-disorders-in-newly-detected-advanced-renal-failure-patients-a-hospital-based-cross-sectional-study
#17
Praveen Kumar Etta, R K Sharma, Amit Gupta
We aim to evaluate the disturbances in mineral metabolism, abnormalities in bone mineral density (BMD), and extraskeletal calcification in newly detected, untreated predialysis stage 4 and 5 chronic kidney disease (CKD) patients at a tertiary care hospital in North India. This is cross-sectional observational study. A total of 95 (68 males, 27 females) newly detected patients underwent clinical evaluation, biochemical assessment [serum calcium, phosphorus, alkaline phosphatase (ALP), albumin, creatinine, intact parathyroid hormone (iPTH), 25- hydroxyvitamin D (25(OH)D)], BMD measurement (at spine, hip, and forearm) by dual-energy X-ray absorptiometry (DXA), lateral abdominal radiograph [for abdominal aortic calcification (AAC)], skeletal survey (to look for any abnormality including fractures), and echocardiography [for any cardiac valvular calcification (CVC)]...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28747968/quinolone-susceptibility-and-genetic-characterization-of-salmonella-enterica-subsp-enterica-isolated-from-pet-turtles
#18
B C J De Silva, Sabrina Hossain, S H M P Wimalasena, H N K S Pathirana, Mitchell Wendt, Gang-Joon Heo
Turtle-borne Salmonella enterica owns significance as a leading cause in human salmonellosis. The current study aimed to determine the quinolone susceptibility and the genetic characteristics of 21 strains of S. enterica subsp. enterica isolated from pet turtles. Susceptibility of four antimicrobials including nalidixic acid, ciprofloxacin, ofloxacin, and levofloxacin was examined in disk diffusion and MIC tests where the majority of the isolates were susceptible to all tested quinolones. In genetic characterization, none of the isolates were positive for qnr or aac(6')-Ib genes and no any target site mutations could be detected in gyrA, gyrB, and parC quinolone resistance determining regions (QRDR)...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28745477/comparison-of-the-responsivity-of-solution-suspended-and-surface-bound-poly-n-isopropylacrylamide-based-microgels-for-sensing-applications
#19
Wenxiang Li, Liang Hu, Jinghua Zhu, Dan Li, Yafei Luan, Wenwen Xu, Michael J Serpe
In this submission, the phase transition behavior for poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAm-co-AAc) microgels and their assemblies was investigated as a function of temperature and pH using UV-vis spectroscopy (to probe light scattering behavior) and quartz crystal microbalance with dissipation (QCM-D) measurements. PNIPAm-co-AAc microgels were "painted" onto Au-coated glass substrates (for UV-vis) and the Au electrode of a QCM crystal to generate monolayers. The subsequent deposition of another Au layer on top of the pNIPAm-co-AAc microgel layer yields what is known as an etalon...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28744172/identification-of-quantitative-trait-loci-for-rice-grain-quality-and-yield-related-traits-in-two-closely-related-oryza-sativa-l-subsp-japonica-cultivars-grown-near-the-northernmost-limit-for-rice-paddy-cultivation
#20
Noriko Kinoshita, Masayuki Kato, Kei Koyasaki, Takuya Kawashima, Tsutomu Nishimura, Yuji Hirayama, Itsuro Takamure, Takashi Sato, Kiyoaki Kato
Quantitative trait loci (QTLs) associated with eating quality, grain appearance quality and yield-related traits were mapped in recombinant inbred lines (RILs) derived from closely related rice (Oryza sativa L. subsp. japonica) cultivars, Yukihikari (good eating quality) and Joiku462 (superior eating quality and high grain appearance quality). Apparent amylose content (AAC), protein content (PC), brown grain length (BGL), brown grain width (BGWI), brown grain thickness (BGT), brown grain weight per plant (BGW) and nine yield-related traits were evaluated in 133 RILs grown in four different environments in Hokkaido, near the northernmost limit for rice paddy cultivation...
June 2017: Breeding Science
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