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https://www.readbyqxmd.com/read/27922855/liver-stiffness-predicts-variceal-bleeding-in-hiv-hcv-coinfected-patients-with-compensated-cirrhosis
#1
Nicolás Merchante, Antonio Rivero-Juárez, Francisco Téllez, Dolores Merino, Maria José Ríos-Villegas, Guillermo Ojeda-Burgos, Mohamed Omar, Juan Macías, Antonio Rivero, Monserrat Pérez-Pérez, Miguel Raffo, Inmaculada López-Montesinos, Manuel Márquez-Solero, Maria Amparo Gómez-Vidal, Juan A Pineda
BACKGROUND: A liver stiffness (LS) < 21 kPa has a high negative predictive value (NPV) to exclude the presence of esophageal varices (EV) at risk of bleeding in HIV/HCV-coinfected patients. Consequently, upper gastrointestinal endoscopy (UGE) for the screening of EV could be avoided in these patients. However, this strategy has not been widely accepted due to concerns about its safety. OBJECTIVE: To assess the ability of LS to predict the risk of portal hypertensive gastrointestinal bleeding (PHGB) in HIV/HCV-coinfected patients with compensated cirrhosis...
December 5, 2016: AIDS
https://www.readbyqxmd.com/read/27787664/impact-of-universal-access-to-hepatitis-c-therapy-on-hiv-infected-patients-implementation-of-the-spanish-national-hepatitis-c-strategy
#2
A Rivero-Juarez, L F Lopez-Cortes, M Castaño, D Merino, M Marquez, M Mancebo, F Cuenca-Lopez, P Jimenez-Aguilar, I Lopez-Montesinos, S Lopez-Cardenas, A Collado, M A Lopez-Ruz, M Omar, F Tellez, X Perez-Stachowski, J Hernandez-Quero, J A Girón-Gonzalez, E Fernandez-Fuertes, A Rivero
In April 2015, the Spanish National Health System (SNHS) developed a national strategic plan for the diagnosis, treatment, and management of hepatitis C virus (HCV). Our aim was to analyze the impact of this on human immunodeficiency virus (HIV)-infected patients included in the HERACLES cohort during the first 6 months of its implementation. The HERACLES cohort (NCT02511496) was set up in March 2015 to evaluate the status and follow-up of chronic HCV infection in patients co-infected with HIV in the south of Spain...
October 27, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27759780/antibiotic-prophylaxis-in-laparoscopic-cholecistectomy-is-it-worth-doing
#3
Márcio Alexandre Terra Passos, Pedro Eder Portari-Filho
Background: Elective laparoscopic cholecystectomy has very low risk for infectious complications, ranging the infection rate from 0.4% to 1.1%. Many surgeons still use routine antibiotic prophylaxis. Aim: Evaluate the real impact of antibiotic prophylaxis in elective laparoscopic cholecystectomies in low risk patients. Method: Prospective, randomized and double-blind study. Were evaluated 100 patients that underwent elective laparoscopic cholecystectomy divided in two groups: group A (n=50), patients that received prophylaxis using intravenous Cephazolin (2 g) during anesthetic induction and group B (n=50), patients that didn't receive any antibiotic prophylaxis...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27513481/-not-available
#4
Fátima Martínez-Lozano Aranaga, Paula Palacios Vales, Juana María Serrano Navarro, Carmen Caballero Requejo, María Jesús Gómez Ramos, Carmen Sánchez Álvarez
Introducción: la composición lipídica de las fórmulas de nutrición parenteral (NP) se postula como posible factor de evolución clínica.Objetivo: evaluar las diferencias en eficacia y seguridad de dos emulsiones lipídicas en NP.Material y métodos: estudio clínico prospectivo de pacientes posquirúrgicos sometidos a NP durante más de 7 días en un periodo de 2 años. Se administraron de forma indistinta 2 tipos de emulsiones lipídicas: enriquecida con ácidos grasos omega 3 (SMOFlipid Fresenius Kabi®) o con ácido oleico omega 9 (Clinoleic Baxter®)...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27444453/-not-available
#5
Fátima Martínez-Lozano Aranaga, Paula Palacios Vales, Juana María Serrano Navarro, Carmen Caballero Requejo, María Jesús Gómez Ramos, Carmen Sánchez Álvarez
Introducción: la composición lipídica de las fórmulas de nutrición parenteral (NP) se postula como posible factor de evolución clínica.Objetivo: evaluar las diferencias en eficacia y seguridad de dos emulsiones lipídicas en NP.Material y métodos: estudio clínico prospectivo de pacientes posquirúrgicos sometidos a NP durante más de 7 días en un periodo de 2 años. Se administraron de forma indistinta 2 tipos de emulsiones lipídicas: enriquecida con ácidos grasos omega 3 (SMOFlipid Fresenius Kabi®) o con ácido oleico omega 9 (Clinoleic Baxter®)...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27424071/executive-summary-of-the-guidelines-for-the-use-of-interferon-gamma-release-assays-in-the-diagnosis-of-tuberculosis-infection
#6
Miguel Santin, José-María García-García, David Rigau, Neus Altet, Luis Anibarro, Irma Casas, Nuria Díez, Mercedes García-Gasalla, Xavier Martínez-Lacasa, Antón Penas, Elvira Pérez-Escolano, Francisca Sánchez, José Domínguez
Interferon-gamma release assays are widely used for the diagnosis of tuberculosis infection in Spain. However, there is no consensus on their application in specific clinical scenarios. To develop a guide-line for their use, a panel of experts comprising specialists in infectious diseases, respiratory diseases, microbiology, pediatrics and preventive medicine, together with a methodologist, conducted a systematic literature search, summarized the findings, rated the quality of the evidence, and formulated recommendations following the Grading of Recommendations of Assessment Development and Evaluations methodology...
September 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27383939/impact-of-long-term-treatment-with-inhaled-corticosteroids-and-bronchodilators-on-lung-function-in-a-patient-with-post-infectious-bronchiolitis-obliterans
#7
Cecilia Calabrese, Nadia Corcione, Gaetano Rea, Francesco Stefanelli, Ilernando Meoli, Alessandro Vatrella
Post-infectious bronchiolitis obliterans (PIBO) is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affected patients, aimed at the prevention and early treatment of pulmonary infections. In recent years, there has been an increase in the incidence of PIBO in the pediatric population. Patients with PIBO are characterized by a progressive decline in lung function, accompanied by a decrease in overall functional capacity...
May 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27383929/evaluating-bronchodilator-response-in-pediatric-patients-with-post-infectious-bronchiolitis-obliterans-use-of-different-criteria-for-identifying-airway-reversibility
#8
Rita Mattiello, Paula Cristina Vidal, Edgar Enrique Sarria, Paulo Márcio Pitrez, Renato Tetelbom Stein, Helena Teresinha Mocelin, Gilberto Bueno Fischer, Marcus Herbert Jones, Leonardo Araújo Pinto
OBJECTIVE: Post-infectious bronchiolitis obliterans (PIBO) is a clinical entity that has been classified as constrictive, fixed obstruction of the lumen by fibrotic tissue. However, recent studies using impulse oscillometry have reported bronchodilator responses in PIBO patients. The objective of this study was to evaluate bronchodilator responses in pediatric PIBO patients, comparing different criteria to define the response. METHODS: We evaluated pediatric patients diagnosed with PIBO and treated at one of two pediatric pulmonology outpatient clinics in the city of Porto Alegre, Brazil...
May 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27368042/tropheryma-whipplei-endocarditis-in-spain-case-reports-of-17-prospective-cases
#9
Lara García-Álvarez, María Mercedes Sanz, Mercedes Marín, MCarmen Fariñas, Miguel Montejo, Josune Goikoetxea, Raquel Rodríguez García, Arístides de Alarcón, Manuel Almela, Núria Fernández-Hidalgo, María Del Mar Alonso Socas, Miguel Ángel Goenaga, Enrique Navas, Luis Vicioso, José Antonio Oteo
Tropheryma whipplei endocarditis is an uncommon condition with very few series and <90 cases reported in the literature. The aim of the study was to analyze the epidemiological, clinical, and outcome characteristics of 17 cases of T. whipplei endocarditis recruited in our country from a multicentric cohort from 25 Spanish hospitals from the Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España.From a total of 3165 cases included in the cohort, 14.2% were diagnosed of blood culture negative endocarditis (BCNE) and 3...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27355468/emerging-arboviruses-and-public-health-challenges-in-brazil
#10
Tamara Nunes Lima-Camara
Environmental modification by anthropogenic actions, disordered urban growth, globalization of international exchange and climate change are some factors that help the emergence and dissemination of human infectious diseases transmitted by vectors. This review discusses the recent entry of three arboviruses in Brazil: Chikungunya, West Nile, and Zika virus, focusing on the challenges for the Country's public health. The Brazilian population is exposed to infections caused by these three arboviruses widely distributed on the national territory and associated with humans...
June 27, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/27100997/cd38-cd8-and-cd38-cd4-t-cells-and-ifn-gamma-874-polymorphism-are-associated-with-a-poor-virological-outcome
#11
Paulo Germano de Carvalho, Raphael de Oliveira Rodrigues, Silvia Fernandes Ribeiro da Silva, Ilana Farias Ribeiro, Herene Barros de Miranda Lucena, Lilian Roberta Costa Martins, Silvia Helena Rabenhorst, Érico Antônio Gomes de Arruda, Aparecida Tiemi Nagao-Dias
The main objective of the work was to evaluate the use of CD38 on T lymphocytes, IFNγ (+874 A/T), and IL-10 (-1082 A/G) polymorphisms in HIV-infected patients under antiretroviral (ARV) therapy. Sixty-one patients were selected at the outpatient clinic for HIV infection at the Hospital São José de Doenças Infecciosas, Fortaleza, Ceará, Brazil. The patients were classified into two groups, according to viral load after one year of ARV therapy. In the aviremic group (group I), a reduction of 35.5% of CD38+CD4+ T cells was observed (p = 0...
May 2016: Immunological Investigations
https://www.readbyqxmd.com/read/26848975/liver-toxicity-of-current-antiretroviral-regimens-in-hiv-infected-patients-with-chronic-viral-hepatitis-in-a-real-life-setting-the-hepavir-seg-hep-cohort
#12
Karin Neukam, José A Mira, Antonio Collado, Antonio Rivero-Juárez, Patricia Monje-Agudo, Josefa Ruiz-Morales, María José Ríos, Dolores Merino, Francisco Téllez, Inés Pérez-Camacho, María Carmen Gálvez-Contreras, Antonio Rivero, Juan A Pineda
OBJECTIVE: To assess the current frequency of ART-associated grade 3-4 transaminase elevations (TE) and grade 4 total bilirubin elevations (TBE) in HIV-infected patients with chronic hepatitis B and/or C, who start a new regimen of ART. PATIENTS AND METHODS: A total of 192 pre-treated or treatment-naive HIV infected patients with HBV and/or HCV-coinfection who started ART in eight Southern Spanish centers from July/2011-December/2013, were followed for 12 months in this prospective study...
2016: PloS One
https://www.readbyqxmd.com/read/26643257/progression-of-liver-stiffness-predicts-clinical-events-in-hiv-hcv-coinfected-patients-with-compensated-cirrhosis
#13
Nicolás Merchante, Francisco Téllez, Antonio Rivero-Juárez, Maria José Ríos-Villegas, Dolores Merino, Manuel Márquez-Solero, Mohamed Omar, Eva Recio, Montserrat Pérez-Pérez, Ángela Camacho, Sara Macías-Dorado, Juan Macías, Sandra Lorenzo-Moncada, Antonio Rivero, Juan A Pineda
BACKGROUND: Our objective was to assess the predictive value of the changes of liver stiffness (LS) for clinical outcome in HIV/HCV-coinfected patients with compensated liver cirrhosis and a LS value < 40 kPa. METHODS: Prospective cohort of 275 HIV/HCV-coinfected patients with cirrhosis, no previous liver decompensation (LD) and LS < 40 kPa. The time from diagnosis to LD and/or hepatocellular carcinoma (HCC) and the predictors of this outcome were evaluated...
2015: BMC Infectious Diseases
https://www.readbyqxmd.com/read/26512582/current-epidemiology-and-outcome-of-infective-endocarditis-a-multicenter-prospective-cohort-study
#14
MULTICENTER STUDY
Patricia Muñoz, Martha Kestler, Arístides De Alarcon, José María Miro, Javier Bermejo, Hugo Rodríguez-Abella, Maria Carmen Fariñas, Manuel Cobo Belaustegui, Carlos Mestres, Pedro Llinares, Miguel Goenaga, Enrique Navas, José Antonio Oteo, Paola Tarabini, Emilio Bouza
The aim of the study was to describe the epidemiologic and clinical characteristics and identify the risk factors of short-term and 1-year mortality in a recent cohort of patients with infective endocarditis (IE).From January 2008, multidisciplinary teams have prospectively collected all consecutive cases of IE, diagnosed according to the Duke criteria, in 25 Spanish hospitals.Overall, 1804 patients were diagnosed. The median age was 69 years (interquartile range, 55-77), 68.0% were men, and 37.1% of the cases were nosocomial or health care-related IE...
October 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26342330/dimension-of-chronic-hepatitis-c-virus-in-hiv-infected-patients-in-the-interferon-free-era-an-overview-from-south-spain
#15
A Rivero-Juarez, A Gutierrez-Valencia, M Castaño, D Merino, K Neukam, M J Ríos-Villegas, M A Lopez-Ruz, P Jiménez-Aguilar, M Marquez, A Collado, A Gomez-Vidal, J Hernandez-Quero, F Tellez, E Fernandez-Fuertes, A Rivero, L F López-Cortés
The implementation of hepatitis C (HCV) direct-acting antiviral drugs is prioritized in several populations in which its application provides the most immediate and impactful benefit. In this scenario, a precise knowledge of the situation of human immunodeficiency virus (HIV)/HCV chronic co-infection is required to adequately address this disease. This cross-sectional study was performed in 21 hospitals in Andalusia (Spain). The study population consisted of HIV-infected patients with an active HCV chronic infection who were not receiving HCV treatment at the time of inclusion...
November 2015: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/26259745/-high-frequency-of-ancestral-allele-of-the-tjp1-polymorphism-rs2291166-in-mexican-population-conformational-effect-and-applications-in-surgery-and-medicine
#16
Sergio Alberto Ramirez-Garcia, Luis Javier Flores-Alvarado, Luz Rosalba Topete-González, Claudia Charles-Niño, Manuel Mazariegos-Rubi, Nory Omayra Dávalos-Rodríguez
BACKGROUND: TJP1 gene encodes a ZO-1 protein that is required for the recruitment of occludins and claudins in tight junction, and is involved in cell polarisation. It has different variations, the frequency of which has been studied in different populations. In Mexico there are no studies of this gene. These are required because their polymorphisms can be used in studies associated with medicine and surgery. Therefore, the aim of this study was to estimate the frequency of alleles and genotypes of rs2291166 gene polymorphism TJP1 in Mexico Mestizos population, and to estimate the conformational effect of an amino acid change...
January 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/26254560/longitudinal-evaluation-of-hepatitis-c-viral-persistence-in-hiv-infected-patients-with-spontaneous-hepatitis-c-clearance
#17
A Rivero-Juarez, A Caruz, L M Real, L Martinez-Dueñas, F J Marquez, M Frias, E Recio, A Gordon, J A Pineda, A Rivero, A Camacho
Hepatitis C virus (HCV) viral persistence in patients with spontaneous viral clearance is controversial. Several studies have shown HCV-RNA in peripheral blood mononuclear cells (PBMCs) and/or liver tissue among patients who have cleared the virus spontaneously, suggesting that viral persistence is a common situation that could involve the entire population studied. Thus, our aim was to evaluate HCV-RNA persistence in PBMCs and hepatocytes in subjects infected with the human immunodeficiency virus (HIV). A total of 1508 patients were prospectively followed and tested for anti-HCV antibodies and HCV-RNA to identify the patients who achieved spontaneous viral clearance...
November 2015: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/26155784/impact-of-hiv-infection-on-sustained-virological-response-to-treatment-against-hepatitis-c-virus-with-pegylated-interferon-plus-ribavirin
#18
MULTICENTER STUDY
P Monje-Agudo, A Castro-Iglesias, A Rivero-Juárez, F Martínez-Marcos, E Ortega-González, L M Real, B Pernas, N Merchante, P Cid, J Macías, M D Merino, A Rivero, A Mena, K Neukam, J A Pineda
It is commonly accepted that human immunodeficiency (HIV) coinfection negatively impacts on the rates of sustained virological response (SVR) to therapy with pegylated interferon plus ribavirin (PR). However, this hypothesis is derived from comparing different studies. The aim of this study was to determine the impact of HIV coinfection on SVR to PR in one single population. In a multicentric, prospective study conducted between 2000 and 2013, all previously naïve hepatitis C virus (HCV)-infected patients who started PR in five Spanish hospitals were analyzed...
October 2015: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/26115631/efficacy-of-and-risk-of-bleeding-during-pegylated-interferon-plus-ribavirin-treatment-in-hiv-hcv-coinfected-patients-with-pretreatment-thrombocytopenia
#19
J A Mira, K Neukam, L F López-Cortés, A Rivero-Juárez, F Téllez, J A Girón-González, I de los Santos-Gil, G Ojeda-Burgos, D Merino, M J Ríos-Villegas, A Collado, A Torres-Cornejo, J Macías, A Rivero, M Pérez-Pérez, J A Pineda
The aim of this study was to assess the efficacy of and the risk of major bleeding during pegylated interferon (peg-IFN)/ribavirin (RBV) treatment among human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients according to the pretreatment platelet count. Two hundred and seventy-four HCV/HIV-coinfected, previously naïve individuals with compensated cirrhosis enrolled in one Spanish prospective cohort who received peg-IFN/RBV were included in this study. The frequency of severe bleeding and sustained virological response (SVR) rate were compared between patients with a pretreatment platelet count ≤70,000/mm(3) and >70,000/mm(3), respectively...
September 2015: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/26049175/-bibliometric-analysis-of-the-spanish-scientific-production-in-infectious-diseases-and-microbiology
#20
José Manuel Ramos, Gregorio González-Alcaide, Félix Gutiérrez
INTRODUCTION: The bibliometric analysis of production and impact of documents by knowledge area is a quantitative and qualitative indicator of research activity in this field. The aim of this article is to determine the contribution of Spanish research institutions in Infectious Diseases and Microbiology in recent years. MATERIAL AND METHODS: Documents published in the journals included in the categories "Infectious Diseases" and "Microbiology" of the Web of Science (Science Citation Index Expanded) of the ISI Web of Knowledge from the year 2000-2013 were analysed...
March 2016: Enfermedades Infecciosas y Microbiología Clínica
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