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Platelet rich plasma knee

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https://www.readbyqxmd.com/read/29313321/the-matrix-synthesis-and-anti-inflammatory-effect-of-autologous-leukocyte-poor-platelet-rich-plasma-in-human-cartilage-explants
#1
Mario Simental-Mendía, Félix Vilchez-Cavazos, Rubén García-Garza, Jorge Lara-Arias, Roberto Montes-de-Oca-Luna, Salvador Said-Fernández, Herminia G Martínez-Rodríguez
OBJECTIVE: To determine the effects of autologous leukocyte-poor platelet-rich plasma (LP-PRP) on the expression of markers involved in cartilage-extracellular matrix production and inflammation in cartilage explants bearing osteoarthritis. MATERIALS AND METHODS: Cartilage explants and LP-PRP were obtained from 10 patients who underwent total knee arthroplasty. The explants were cultured in spinner flasks for 28 days in the presence of interleukin (IL)-1β and/or LP-PRP...
January 9, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29297976/platelet-responses-to-pharmacological-and-physiological-interventions-in-middle-aged-men-with-different-habitual-physical-activity-levels
#2
M H Lundberg Slingsby, L Gliemann, M Thrane, N Rytter, J Egelund, M V Chan, P C Armstrong, T D Warner, Y Hellsten
The current guidelines following an acute coronary syndrome recommend dual anti-platelet therapy (aspirin plus a P2Y12 antagonist) alongside lifestyle modifications, including more regular physical activity. It is currently unknown if regular exercise affects the pharmacology of dual anti-platelet therapy. AIM: To explore how exercise-induced improvements in vascular and platelet function affect the efficacy of dual anti-platelet therapy, in a cross-sectional study of men with different physical activity level (training status)...
January 3, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29291543/platelet-rich-plasma-inhibits-wnt-%C3%AE-catenin-signaling-in-rabbit-cartilage-cells-activated-by-il-1%C3%AE
#3
Jian Wu, Ji-Feng Huang, Xing-Xing Qin, Feng Hu, Zhao-Fei Chen, Yong Zheng, Yan-Xi Liu, Xian-Hua Cai
OBJECTIVE: Platelet-rich plasma (PRP) has been reported to alleviate degenerative pathological damage to joint cartilage. This study aimed to investigate the effect of PRP on Wnt/β-catenin signaling in rabbit chondrocytes. METHODS: Using 3-month-old New Zealand white rabbits, PRP was prepared from venous blood, and chondrocytes were cultured from knee joint cartilage and identified by staining for type II collagen and proteoglycan. The effects of PRP on chondrocyte viability were measured...
December 29, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29240523/injectable-platelet-rich-fibrin-using-the-low-speed-centrifugation-concept-improves-cartilage-regeneration-when-compared-to-platelet-rich-plasma
#4
Mustafa Abd El Raouf, Xuzhu Wang, Si Miusi, Jihua Chai, Abdel Basit Mohamed AbdEl-Aal, Mekkawy M Nefissa Helmy, Shahram Ghanaati, Joseph Choukroun, Elisa Choukroun, Yufeng Zhang, Richard J Miron
The aim of the present study was to evaluate the effect of injectable platelet-rich fibrin (i-PRF) on cultivated chondrocytes and osteochondral regeneration in critical-sized osteochondral defect of the rabbit's knee in comparison to autologous platelet-rich plasma (PRP). Chondrocytes were first investigated for their ability to proliferate and differentiate in response to PRP and i-PRF. Thereafter, full-thickness critical-sized osteochondral defects 5 mm in diameter and 5 mm in depth were created in the knee joint of 12 adult female New Zealand White rabbits...
December 14, 2017: Platelets
https://www.readbyqxmd.com/read/29211969/use-of-platelet-rich-plasma-immediately-after-an-injury-did-not-improve-ligament-healing-and-increasing-platelet-concentrations-was-detrimental-in-an-in-vivo-animal-model
#5
Robert F LaPrade, Laurie R Goodrich, Jennifer Phillips, Grant J Dornan, Travis Lee Turnbull, Michael L Hawes, Kimi D Dahl, Ashley N Coggins, John Kisiday, David Frisbie, Jorge Chahla
BACKGROUND: Limited information in basic science and clinical trials exists to determine if ligament healing may be accelerated with the use of biological adjuvants, such as platelet-rich plasma (PRP). However, there has been widespread acceptance of PRP for use in clinical practice, despite an inadequate understanding of its biological mechanism of action. PURPOSE: To determine whether a single dose of PRP could accelerate ligament healing and correspondingly improve histological characteristics and biomechanical properties when injected immediately postoperatively into the injured medial collateral ligament (MCL) of New Zealand White rabbits...
December 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29210705/effects-of-platelet-rich-plasma-on-pain-and-muscle-strength-in-patients-with-knee-osteoarthritis
#6
Yung-Tsan Wu, Kao-Chih Hsu, Tsung-Ying Li, Cheng-Kuang Chang, Liang-Cheng Chen
OBJECTIVE: No studies comparing the effects of platelet-rich plasma (PRP) injection and placebo injection in bilateral knee osteoarthritis (OA) in the same patient, or discussing muscle strength after PRP injection, have been published. DESIGN: Twenty patients with bilateral knee OA were eligible, and 40 knees were randomized into two groups: PRP (knees [right or left by a coin toss] receiving a single intra-articular PRP injection) and saline group (the contralateral knee of the same patient, into which single 4-mL intra-articular injection of normal saline was administered)...
November 29, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29210206/intra-articular-platelet-rich-plasma-injections-for-knee-osteoarthritis-an-overview-of-systematic-reviews-and-risk-of-bias-considerations
#7
Dan Xing, Bin Wang, Wei Zhang, Ziyi Yang, Yunfei Hou, Yaolong Chen, Jianhao Lin
OBJECTIVES: Numerous systematic reviews investigating the efficacy of platelet-rich plasma (PRP) in treating knee osteoarthritis (OA) have been recently published. The purpose of the present study was (1) to perform an overview of overlapping systematic reviews investigating PRP for knee OA via evaluating methodological quality and risk of bias of systematic reviews and (2) to provide recommendations through the best evidence. METHODS: A systematic search of systematic reviews published through Feb 2017 was conducted using the MEDLINE, EMBASE and Cochrane Library...
December 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29194097/an-autologous-leukocyte-reduced-platelet-rich-plasma-therapy-for-chronic-injury-of-the-medial-collateral-ligament-in-the-knee-a-report-of-3-successful-cases
#8
Mamoru Yoshida, Keishi Marumo
Some patients complain of chronic persistent medial knee pain after isolated low-grade injuries of medial collateral ligaments (MCL). These injuries often respond to various conservative treatments but insufficient healing of ligaments is believed to be responsible for symptoms in this group of patients. We report on successful treatment of chronically symptomatic MCL injuries in 3 patients using autologous leukocyte-reduced platelet-rich plasma (PRP) injections. There were 3 men with a mean age of 39.3 years and a mean disease duration of 10 months...
November 29, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29160369/biomechanical-study-of-the-effect-of-platelet-rich-plasma-on-the-treatment-of-medial-collateral-ligament-lesion-in-rabbits
#9
Eduardo Louzada da Costa, Luiz Eduardo Moreira Teixeira, Bruno Jannotti Pádua, Ivana Duval de Araújo, Leonardo de Souza Vasconcellos, Luide Scalioni Borges Dias
PURPOSE: To evaluate the use of platelet-rich plasma in the early stages of healing of traumatic injury of the medial collateral ligament in the knee of rabbits. METHODS: Thirty rabbits were subjected to surgical lesion of the medial collateral ligament. Of these, 16 were treated with platelet-rich plasma and 14 with saline (control). After 3 and 6 weeks of treatment, 50% of the animals from each group were sacrificed, and biomechanical tests were performed on the injured ligament to compare the tensile strength between the two groups...
October 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29156980/platelet-rich-plasma-and-hyaluronic-acid-are-not-synergistic-when-used-as-biological-adjuncts-with-autologous-osteochondral-transplantation
#10
Niall A Smyth, Keir A Ross, Amgad M Haleem, Charles P Hannon, Christopher D Murawski, Huong T Do, John G Kennedy
INTRODUCTION: Autologous osteochondral transplantation (AOT) is a treatment for osteochondral lesions with known concerns, including histological degradation of the graft and poor cartilage integration. Platelet-rich plasma (PRP) and hyaluronic acid (HA) have been described has having the potential to improve results. The aim of this study was to evaluate the effect of PRP and HA on AOT in a rabbit model. METHODS: Thirty-six rabbits underwent bilateral knee AOT treated with either the biological adjunct (PRP, n = 12; HA, n = 12; PRP + HA, n = 12) or saline (control)...
January 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29146943/cryopreservation-of-human-mesenchymal-stem-cells-in-an-allogeneic-bioscaffold-based-on-platelet-rich-plasma-and-synovial-fluid
#11
Haritz Gurruchaga, Laura Saenz Del Burgo, Ane Garate, Diego Delgado, Pello Sanchez, Gorka Orive, Jesús Ciriza, Mikel Sanchez, Jose Luis Pedraz
Transplantation of mesenchymal stem cells (MSCs) has emerged as an alternative strategy to treat knee osteoarthritis. In this context, MSCs derived from synovial fluid could provide higher chondrogenic and cartilage regeneration, presenting synovial fluid as an appropriate MSCs source. An allogeneic and biomimetic bioscaffold composed of Platelet Rich Plasma and synovial fluid that preserve and mimics the natural environment of MSCs isolated from knee has also been developed. We have optimized the cryopreservation of knee-isolated MSCs embedded within the aforementioned biomimetic scaffold, in order to create a reserve of young autologous embedded knee MSCs for future clinical applications...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29125811/does-leukocyte-poor-or-leukocyte-rich-platelet-rich-plasma-applied-with-biopolymers-have-superiority-to-conventional-platelet-rich-plasma-applications-on-chondrocyte-proliferation
#12
Duygu Yaşar Şirin, İbrahim Yılmaz, Mehmet İsyar, Kadir Öznam, Mahir Mahiroğulları
OBJECTIVES: This study aims to investigate the possible effects of leukocyte concentration in the content of platelet-rich plasma (PRP) and the administration of PRP using a drug delivery system on chondrocyte proliferation in vitro conditions. PATIENTS AND METHODS: Blood from nine male patients (mean age 65 years; range 49 to 81 years) with advanced stage osteoarthritis who had not responded to medical or conservative treatments and underwent total knee arthroplasty was used to prepare two formulations: PRP with low concentration leukocytes (2000-4000 leukocytes/µL) was designated as pure PRP (P-PRP), whereas PRP with high concentration leukocytes (9000-11000 leukocytes/µL) as leukocyte-rich PRP (L-PRP)...
December 2017: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/29124077/can-a-clinical-examination-demonstrate-intramuscular-tendon-involvement-in-acute-hamstring-injuries
#13
Michel D Crema, Ali Guermazi, Gustaaf Reurink, Frank W Roemer, Mario Maas, Adam Weir, Maarten H Moen, Gert J Goudswaard, Johannes L Tol
Background: Involvement of the intramuscular (central) tendon in acute hamstring injuries, as detected on magnetic resonance imaging (MRI), may prolong recovery times. To date, it is unclear whether hamstring injuries exhibiting intramuscular tendon involvement can be identified though routine clinical examinations that assess flexibility and strength. Purpose: To test whether MRI-detected intramuscular tendon involvement could be identified by a clinical assessment of muscle strength and flexibility...
October 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29114622/single-platelet-rich-plasma-injection-for-early-stage-of-osteoarthritis-of-the-knee
#14
Liborio Ingala Martini, Alessio Giai Via, Chiara Fossati, Filippo Randelli, Pietro Randelli, Davide Cucchi
Purpose  The purpose of this study was to determine the safety efficacy and outcomes of platelet-rich plasma (PRP) intra-articular injections for early stages of knee osteoarthritis (OA). Methods  Twenty-five patients affected by grade I and II knee primary OA according to the Kellgren-Lawrence scale received a single intra-articular PRP injection. Patients were prospectively evaluated for 6 months. Visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Knee injury and Osteoarthritis Outcome Score (KOOS) scoring scales were used to evaluate clinical outcomes...
March 2017: Joints
https://www.readbyqxmd.com/read/29083347/current-concepts-in-treatment-of-early-knee-osteoarthritis-and-osteochondral-lesions-the-role-of-biological-augmentations
#15
C Dall'Oca, M Cengarle, A Costanzo, N Giannini, A Vacchiano, B Magnan
Early knee osteoarthritis and chondral lesions are a common cause of disability in younger patients. Surgical options, such as microfractures, ACI and OAT, provide good, but not fully satisfying, outcomes. Recent advance in biological knowledge introduced two different methodological approaches of delivering growth factors and stem cells into the articular environment. Platelet-Rich Plasma and Mesenchimal Stem Cells are supposed to change the way to approach early knee osteoarthritis and chondral lesions, though their indications and limits are yet to be determined...
October 18, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29056974/avoidance-of-total-knee-arthroplasty-in-early-osteoarthritis-of-the-knee-with-intra-articular-implantation-of-autologous-activated-peripheral-blood-stem-cells-versus-hyaluronic-acid-a-randomized-controlled-trial-with-differential-effects-of-growth-factor-addition
#16
Thana Turajane, Ukrit Chaveewanakorn, Warachaya Fongsarun, Jongjate Aojanepong, Konstantinos I Papadopoulos
In this randomized controlled trial, in early osteoarthritis (OA) that failed conservative intervention, the need for total knee arthroplasty (TKA) and WOMAC scores were evaluated, following a combination of arthroscopic microdrilling mesenchymal cell stimulation (MCS) and repeated intra-articular (IA) autologous activated peripheral blood stem cells (AAPBSCs) with growth factor addition (GFA) and hyaluronic acid (HA) versus IA-HA alone. Leukapheresis-harvested AAPBSCs were administered as three weekly IA injections combined with HA and GFA (platelet-rich plasma [PRP] and granulocyte colony-stimulating factor [hG-CSF]) and MCS in group 1 and in group 2 but without hG-CSF while group 3 received IA-HA alone...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29031987/intra-articular-injection-of-mesenchymal-stem-cells-and-platelet-rich-plasma-to-treat-patellofemoral-osteoarthritis-preliminary-results-of-a-long-term-pilot-study
#17
Julien Pintat, Alain Silvestre, Guy Magalon, Alain Pierre Gadeau, Lionel Pesquer, Anne Perozziello, Alain Peuchant, Charbel Mounayer, Benjamin Dallaudière
PURPOSE: To assess the feasibility and safety of concomitant intra-articular (IA) knee injection of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) under fluoroscopic guidance to treat patellofemoral osteoarthritis (OA). MATERIALS AND METHODS: This prospective study included 19 consecutive patients referred for fluoroscopically guided IA MSC and PRP injection for symptomatic patellofemoral chondropathy in which conservative treatment had failed. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and magnetic resonance (MR) data, including T2 mapping sequence, were prospectively collected before and 6 months after treatment...
December 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29027349/aerobic-exercise-training-lowers-platelet-reactivity-and-improves-platelet-sensitivity-to-prostacyclin-in-pre-and-postmenopausal-women
#18
M H Lundberg Slingsby, M Nyberg, J Egelund, C M Mandrup, R Frikke-Schmidt, N S Kirkby, Y Hellsten
Essentials It is unknown how regular exercise affects platelet function after menopause. We studied the effect of 3-months of high-intensity exercise in pre- and postmenopausal women. Platelet sensitivity to the inhibitory effect of arterially infused prostacyclin was increased. Reduced basal platelet reactivity was seen in the premenopausal women only. SUMMARY: Background The risk of atherothrombotic events increases after the menopause. Regular physical activity has been shown to reduce platelet reactivity in younger women, but it is unknown how regular exercise affects platelet function after the menopause...
December 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29026341/benefits-of-different-postoperative-treatments-in-patients-undergoing-knee-arthroscopic-debridement
#19
Cesáreo Trueba Vasavilbaso, Carlos David Rosas Bello, Erla Medina López, Maria Pilar Coronel Granado, José Mario Navarrete Álvarez, Cesáreo Angel Trueba Davalillo, Félix Isaac Gil Orbezo
PURPOSE: To assess the effectiveness of viscosupplementation or platelet-rich plasma (PRP), compared to standard care, for pain relief after knee arthroscopic debridement in patients with meniscal pathology and osteoarthritis (OA), under normal clinical practice conditions. PATIENTS AND METHODS: We conducted a prospective, randomized, evaluator-blind, pilot study. After arthroscopy, patients were randomized to receive 1) five injections of HA1 (Suprahyal®/Adant®); 2) four injections of HA2 (Orthovisc®); 3) three injections of HA3 (Synvisc®); 4) a single injection of PRP (GPS™ II); or 5) standard care (control)...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28993845/-new-experimental-strategies-in-cartilage-surgery
#20
REVIEW
L Rackwitz, J C Reichert, O Pullig, U Nöth
BACKGROUND: Cell and growth factor based strategies bear great potential to support the healing processes in cartilage repair and the therapy of osteoarthritic joints. OBJECTIVES: The following review provides an overview of novel experimental strategies for the therapy of focal cartilage defects and osteoarthritis, with emphasis on cell and growth factor based approaches. MATERIALS AND METHODS: The authors summarize their own data regarding the intraarticular injection of stem cells to treat osteoarthritis of the knee and provide a synopsis of the available literature discussing the most significant publications...
November 2017: Der Orthopäde
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