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kidney cancer evaluation

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https://www.readbyqxmd.com/read/27909903/obesity-and-kidney-cancer
#1
Kathryn M Wilson, Eunyoung Cho
Renal cell cancer (RCC) is the major type of kidney cancer with increasing incidence. Obesity is one of the well-established risk factors for RCC. Meta-analyses including multiple cohort and case-control studies have found a consistent positive association between obesity and RCC. The association appeared to be independent of other RCC risk factors including hypertension and has been often stronger in women, although a positive association has also been observed in men. Obesity has been largely measured as body mass index (BMI)...
2016: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27908924/excess-weight-as-a-risk-factor-common-to-many-cancer-sites-words-of-caution-when-interpreting-meta-analytic-evidence
#2
Melina Arnold, Andrew G Renehan, Graham A Colditz
For over a decade, excess body weight, commonly categorized as overweight (body mass index, BMI: 25.0 to 29.9 kg/m2) and obesity (BMI: ≥ 30 kg/m2) has been an established incidence risk factor for several adult cancers (1). For 2012, the burden of disease attributed to elevated BMI was estimated as nearly half-million new cancers worldwide, making this the third highest ranked cancer risk factor globally after smoking and infections (ranked second in most western populations) and an important public health problem (2, 3)...
December 1, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27900942/association-between-chronic-kidney-disease-and-cancer-mortality-a-report-from-the-allhat
#3
Dhruti P Chen, Barry R Davis, Lara M Simpson, William C Cushman, Jeffrey A Cutler, Mirela Dobre, Charles E Ford, Gail T Louis, Paul Muntner, Suzanne Oparil, Linda B Piller, Sara L Pressel, Mark J Sarnak, Paul K Whelton, Jackson T Wright, Mahboob Rahman
BACKGROUND/OBJECTIVES: Chronic kidney disease (CKD) and cancer are both common in older patients; whether CKD increases risk for cancer is unclear. This study evaluated CKD as a risk factor for cancer mortality in a large cohort of hypertensive patients. STUDY DESIGN: We did post-hoc analyses of in-trial and post-trial data from participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). SETTING AND PARTICIPANTS: Participants were ≥ 55 years old with hypertension and one other additional risk factor for coronary heart disease...
November 30, 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27900057/in-vitro-and-in-vivo-inhibition-of-tumor-cell-viability-by-combined-dihydroartemisinin-and-doxorubicin-treatment-and-the-underlying-mechanism
#4
Xiang Tai, Xiao-Bei Cai, Zhang Zhang, Rui Wei
The natural extract artemisinin and its derivatives have good anticancer activity. The present study aimed to investigate the in vitro inhibitory effects of combined dihydroartemisinin (DHA) and doxorubicin (DOX) treatment on a variety of tumor cell lines (HeLa, OVCAR-3, MCF-7, PC-3 and A549), as well as the underlying mechanisms. In addition, the in vivo effects of DHA and DOX were evaluated using a mouse HeLa tumor model. The HeLa, OVCAR-3, MCF-7, PC-3 and A549 cells were treated with a combination of DHA and DOX, and the effect on cell viability was detected by Cell Counting kit-8...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899981/the-effect-and-clinical-efficacy-of-lienal-polypeptide-injection-combined-with-folfox-chemotherapy-regimen-in-colon-cancer-patients
#5
Juan Zhou, Guoping Niu, Yunfeng Pei, Chunping Cao, Chen Ding, Guangming Sun, Jing Guo, Yong Liu, Yang Yu
The aim was to investigate the clinical efficacy and immunomodulatory effect of lienal polypeptide injection combined with postoperative FOLFOX chemotherapy regimen in colon cancer patients. A total of 84 colon cancer patients were selected between January, 2014 and December, 2015. The selected patients were randomly divided into the observation (42 patients) and control (42 patients) groups. The observation group patients were treated with FOLFOX chemotherapy regimen combined with lienal polypeptide, whereas, the control group patients were treated with FOLFOX chemotherapeutic regimen only...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899233/clear-cell-type-a-and-b-molecular-subtypes-in-metastatic-clear-cell-renal-cell-carcinoma-tumor-heterogeneity-and-aggressiveness
#6
Daniel J Serie, Richard W Joseph, John C Cheville, Thai H Ho, Mansi Parasramka, Tracy Hilton, R Houston Thompson, Bradley C Leibovich, Alexander S Parker, Jeanette E Eckel-Passow
BACKGROUND: Intratumor molecular heterogeneity has been reported for primary clear cell renal cell carcinoma (ccRCC) tumors; however, heterogeneity in metastatic ccRCC tumors has not been explored. OBJECTIVE: To evaluate intra- and intertumor molecular heterogeneity in resected metastatic ccRCC tumors. DESIGN, SETTING, AND PARTICIPANTS: We identified 111 patients who had tissue available from their primary tumor and at least one metastasis...
November 26, 2016: European Urology
https://www.readbyqxmd.com/read/27896628/clinical-translation-of-tumor-acidosis-measurements-with-acidocest-mri
#7
Kyle M Jones, Edward A Randtke, Eriko S Yoshimaru, Christine M Howison, Pavani Chalasani, Robert R Klein, Setsuko K Chambers, Phillip H Kuo, Mark D Pagel
PURPOSE: We optimized acido-chemical exchange saturation transfer (acidoCEST) magnetic resonance imaging (MRI), a method that measures extracellular pH (pHe), and translated this method to the radiology clinic to evaluate tumor acidosis. PROCEDURES: A CEST-FISP MRI protocol was used to image a flank SKOV3 tumor model. Bloch fitting modified to include the direct estimation of pH was developed to generate parametric maps of tumor pHe in the SKOV3 tumor model, a patient with high-grade invasive ductal carcinoma, and a patient with metastatic ovarian cancer...
November 28, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27890855/linker-stability-influences-the-anti-tumor-activity-of-acetazolamide-drug-conjugates-for-the-therapy-of-renal-cell-carcinoma
#8
Samuele Cazzamalli, Alberto Dal Corso, Dario Neri
Small molecule-drug conjugates (SMDCs) are increasingly being considered as an alternative to antibody-drug conjugates (ADCs) for the selective delivery of anticancer agents to the tumor site, sparing normal tissues. Carbonic anhydrase IX (CAIX) is a membrane-bound enzyme, which is over-expressed in the majority of renal cell carcinomas and which can be efficiently targeted in vivo, using charged derivatives of acetazolamide, a small heteroaromatic sulfonamide. Here, we show that SMDC products, obtained by the coupling of acetazolamide with monomethyl auristatin E (MMAE) using dipeptide linkers, display a potent anti-tumoral activity in mice bearing xenografted SKRC-52 renal cell carcinomas...
November 24, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27876925/therapeutic-effect-of-arctium-lappa-in-schistosoma-haematobium-associated-kidney-disturbance-biochemical-and-molecular-effects
#9
Khaled M M Koriem, Zulzamri H Idris, Hasniza F Haron, Nurulhuda A Omar, Halita S Lazain
Schistosoma haematobium (S. haematobium) infection has been found to be strongly associated with bladder cancer, which necessitates for discover of a natural new therapeutic agent. The aim of this study was to evaluate the therapeutic effect of Arctium lappa seed extract in S. haematobium associated kidney disturbance. Forty male albino mice were used and divided into four equal groups; group 1 control includes non-infected healthy mice, groups 2, 3 and 4 subcutaneous infected with S. haematobium cercariae...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27870915/effects-of-angiopoietin-2-on-transplanted-mouse-ovarian-tissue
#10
Hye Won Youm, Jaewang Lee, Eun Jung Kim, Hyun Sun Kong, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
Transplantation of ovarian tissue (OT) is currently the only clinical option to restore fertility with cryopreserved OT. However, follicle loss caused by ischemia and slow revascularization occurs in transplanted OT. To shorten the ischemic period and promote angiogenesis, some angiogenic factors have been used. Angiopoietin-2 (Ang2) is one of the major angiogenic factors and has been reported to promote blood vessels and increase vascular permeability in ischemic and/or hypoxic environment. This study was performed to investigate the effects of Ang2 on follicle integrity and revascularization of transplanted mouse OT...
2016: PloS One
https://www.readbyqxmd.com/read/27866208/kidney-cancer-linked-to-chronic-hepatitis-in-the-asia-pacific-a-population-based-analysis
#11
Yu-Shan Lin, Chih-Ching Yeh, Yen-Chung Lin, Chien-Tien Su, Fung-Chang Sung, Shih-Ni Chang, Yun-Ru Liu, Fu-Hsiung Su
BACKGROUND: The association of renal cancer with viral hepatitis infection remains unclear. Using an insurance data set, this population-based case-control study evaluated the association of renal cancer with chronic hepatitis virus infection in an endemic area of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. METHODS: We enrolled 17,747 patients with renal cancer during the period from 2000 to 2011 from the National Health Insurance Research Database of Taiwan...
November 19, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27865131/evaluation-of-cellular-uptake-cytotoxicity-and-cellular-ultrastructural-effects-of-heteroleptic-oxidovanadium-iv-complexes-of-salicylaldimines-and-polypyridyl-ligands
#12
Gonzalo Scalese, Isabel Correia, Julio Benítez, Santiago Rostán, Fernanda Marques, Filipa Mendes, António Pedro Matos, João Costa Pessoa, Dinorah Gambino
Searching for prospective vanadium-based drugs for cancer treatment, a new series of structurally related [V(IV)O(L-2H)(NN)] compounds (1-8) was developed. They include a double deprotonated salicylaldimine Schiff base ligand (L-2H) and different NN-polypyridyl co-ligands having DNA intercalating capacity. Compounds were characterized in solid state and in solution. EPR spectroscopy suggests that the NN ligands act as bidentate and bind through both nitrogen donor atoms in an axial-equatorial mode. The cytotoxicity was evaluated in human tumoral cells (ovarian A2780, breast MCF7, prostate PC3)...
November 9, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27863441/sulforaphane-inhibits-proliferation-and-invasive-activity-of-everolimus-resistant-kidney-cancer-cells-in-vitro
#13
Eva Juengel, Sebastian Maxeiner, Jochen Rutz, Saira Justin, Frederik Roos, Wael Khoder, Igor Tsaur, Karen Nelson, Wolf O Bechstein, Axel Haferkamp, Roman A Blaheta
Although the mechanistic target of rapamycin (mTOR) inhibitor, everolimus, has improved the outcome of patients with renal cell carcinoma (RCC), improvement is temporary due to the development of drug resistance. Since many patients encountering resistance turn to alternative/complementary treatment options, an investigation was initiated to evaluate whether the natural compound, sulforaphane (SFN), influences growth and invasive activity of everolimus-resistant (RCCres) compared to everolimus-sensitive (RCCpar) RCC cell lines in vitro...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27861254/bilateral-diffuse-uveal-melanocytic-proliferation-associated-with-renal-cancer-the-importance-of-indocyanine-green-angiography-and-early-diagnosis
#14
Vinicius F Kniggendorf, Elmar T Neto, Elizabeth M Maia, Joao P S Grando, Anne M C Bardal, Patrícia M M Beato, Caroline C Torres, Mauricio Maia
PURPOSE: To report a case of bilateral diffuse uveal melanocytic proliferation associated with renal carcinoma and to illustrate the importance of ancillary examinations to early diagnosis and treatment. DESIGN: Clinical case report. METHODS: A 56-year-old man reported a 3-day history of visual impairment and scotoma in the right eye. An ophthalmoscopic examination, visual field test, fundus autofluorescence, fluorescein angiography, indocyanine green angiography, optical coherence tomography, and systemic evaluation were performed...
November 17, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27852261/mpc1-and-mpc2-expressions-are-associated-with-favorable-clinical-outcomes-in-prostate-cancer
#15
Xiaoli Li, Yasai Ji, Gaoyang Han, Xiaoran Li, Zhirui Fan, Yaqing Li, Yali Zhong, Jing Cao, Jing Zhao, Mingzhi Zhang, Jianguo Wen, Mariusz Adam Goscinski, Jahn M Nesland, Zhenhe Suo
BACKGROUND: Cancer cells exhibit an altered metabolism, which is characterized by a preference for aerobic glycolysis more than mitochondrial oxidation of pyruvate. Mitochondrial pyruvate carrier 1 (MPC1) and mitochondrial pyruvate carrier 2 (MPC2) play a bottleneck role by transporting pyruvate into mitochondrial through the mitochondrial inner membrane. Therefore, their protein expression in cancers may be of clinical consequences. There are studies showing low levels of MPC1 expression in colon, kidney and lung cancers, and the expression of MPC1 correlates with poor prognosis...
November 16, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27846002/renal-metastasis-from-primary-thyroid-cancer-on-131i-and-mri-imaging
#16
Darshan R Patel, Bhishak H Kamat, Michael D Farwell
A 66-year-old woman with a history of papillary thyroid cancer status after total thyroidectomy underwent I radioiodine ablation therapy 3 months after surgery. Posttherapy whole body planar imaging revealed focal intense I uptake in the posterior right abdomen. SPECT/CT of this region localized the uptake to the medial lower pole of the right kidney. Further evaluation with MRI demonstrated a correlative suspicious right renal mass. The patient underwent right partial nephrectomy with pathology demonstrating that the renal mass was of thyroidal origin (papillary subtype)...
November 11, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27821818/de-novo-malignancy-in-organ-transplant-recipients-in-taiwan-a-nationwide-cohort-population-study
#17
Hsin-I Tsai, Chao-Wei Lee, Chang-Fu Kuo, Lai-Chu See, Fu-Chao Liu, Meng-Jiun Chiou, Huang-Ping Yu
Organ transplant recipients appear to have a higher risk of de novo malignancy. The aim of the study was designed to estimate cancer risk in heart, lung, kidney and liver transplant recipients. The cohort study used the Taiwan National Health Insurance Research Database (1996-2011) and followed the outcomes of organ recipients until 2012. De novo cancer and mortality rates after organ transplantation were evaluated using standardized incidence ratios, excess absolute risks of cancer, and standardized mortality ratios in recipients were compared with those in the general population...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27816641/development-and-evaluation-of-topotecan-loaded-solid-lipid-nanoparticles-a-study-in-cervical-cancer-cell-lines
#18
Zhao-Jie Chen, Zhen Zhang, Bei-Bei Xie, Hai-Yan Zhang
The study aims at statistical development of solid lipid nanoparticles (SLNs) loaded with topotecan hydrochloride for avoiding the drawbacks of conventional drug therapies used in cervical cancer. Twenty SLN batches were prepared using organic solvent evaporation method to provide response surface curves. Thereafter, optimized SLNs were obtained using numeric method based on desirability functions providing maximum drug loading and appropriate particle size. Physical characterization of optimized TPH loaded SLNs was performed in terms of particle size, zeta potential, transmission and scanning electron microscopic evaluation...
October 18, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27815768/diabetes-and-kidney-cancer-outcomes-a-propensity-score-analysis
#19
Madhur Nayan, Antonio Finelli, Michael A S Jewett, David N Juurlink, Peter C Austin, Girish S Kulkarni, Robert J Hamilton
There is conflicting evidence whether diabetes is associated with survival outcomes in patients undergoing a nephrectomy for renal cell carcinoma. We performed a retrospective review of 1034 patients undergoing nephrectomy for unilateral, M0, renal cell carcinoma between 2000 and 2016 at a tertiary academic center. Inverse probability of treatment weights were derived from a propensity score model based on various clinical, surgical, and pathological characteristics. We used Cox proportional hazard models to evaluate the association between diabetes and disease-free survival, cancer-specific survival, and overall survival in the sample weighted by the inverse probability of treatment weights...
November 4, 2016: Endocrine
https://www.readbyqxmd.com/read/27814278/functional-analysis-of-serum-micrornas-mir-21-and-mir-106a-in-renal-cell-carcinoma
#20
Hamulati Tusong, Naibijiang Maolakuerban, Jin Guan, Mulati Rexiati, Wen-Guang Wang, Baihetiya Azhati, Yiliyaer Nuerrula, Yu-Jie Wang
OBJECTIVE: microRNAs (miRNAs) plays an important role in tumor development and progression and act as oncogenes or tumor suppressor genes in the carcinogenesis process. miRNA is stable in serum, and recent studies have demonstrated the feasibility of using circulating miRNA as biomarkers in cancer patients. However, currently, no serum biomarkers for the early diagnosis and prognosis of renal cell carcinoma (RCC) have been reported. Therefore, a new molecular marker for early diagnosis and evaluation of recurrence after surgery is required...
October 28, 2016: Cancer Biomarkers: Section A of Disease Markers
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