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Recurrent tract infection in women

Piera Valenti, Luigi Rosa, Daniela Capobianco, Maria Stefania Lepanto, Elisa Schiavi, Antimo Cutone, Rosalba Paesano, Paola Mastromarino
The innate defense system of the female mucosal genital tract involves a close and complex interaction among the healthy vaginal microbiota, different cells, and various proteins that protect the host from pathogens. Vaginal lactobacilli and lactoferrin represent two essential actors in the vaginal environment. Lactobacilli represent the dominant bacterial species able to prevent facultative and obligate anaerobes outnumber in vaginal microbiota maintaining healthy microbial homeostasis. Several mechanisms underlie the protection exerted by lactobacilli: competition for nutrients and tissue adherence, reduction of the vaginal pH, modulation of immunity, and production of bioactive compounds...
2018: Frontiers in Immunology
Antonio Cianci, Ettore Cicinelli, Vincenzo De Leo, Franca Fruzzetti, Maria Giulia Massaro, Alessandro Bulfoni, Fabio Parazzini, Antonio Perino
We performed a prospective cohort parallel observational study on the use of Lactobacillus plantarum P 17630 in the prevention of vaginal infections. Eligible were women with a diagnosis of bacterial vaginosis (<15 days) and documented history of recurrent vaginal infections; and/or cystitis (<15 days); and/or treatment with antibiotics for bacterial respiratory tract infections during the week before the study entry. Study subjects were prescribed Lactobacillus plantarum P 17630 > 100.000...
March 12, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Kostis Gyftopoulos
Recurrent urinary tract infections (rUTI) in women is a common cause of morbidity worldwide. In young women recurrent cystitis associated with sexual intercourse is quite common; however not all sexually active women will suffer a post-coital UTI episode. A variety of possible predisposing factors has been described, including behavioral risk patterns, genetic factors and increased virulence of certain subtypes of uropathogens. It has long been regarded that anatomical anomalies are rare in this setting of rUTIs...
April 2018: Medical Hypotheses
Jesus Salinas-Casado, Santiago Méndez-Rubio, Manuel Esteban-Fuertes, Antonio Gómez-Rodríguez, Miguel Vírseda-Chamorro, Marcos Luján-Galán, Grupo Rituman
OBJECTIVE: To compare the efficacy and safety of dietary supplement "Manosar®" composed of D-mannose (2 g), 24 h prolonged release, associated with Proanthocyanidin (PAC) (140 mg), ursolic acid (7.98 mg), A, C, and D vitamins and the oligoelement zinc, versus 240 mg of PAC in recurrent urinary tract infections (UTI), for a designed follow-up of 24 weeks, in women. METHODS: A multicenter randomized experimental double-blind study was carried out. The study was approved by review board of "Complejo Hospitalario de Toledo" (Spain), and all patients gave informed consent...
March 2018: Archivos Españoles de Urología
Katy Díaz, Luis Espinoza, Alejandro Madrid, Leonardo Pizarro, Rolando Chamy
Currently, the most effective treatment for recurrent urinary tract infections in women is antibiotics. However, the limitation for this treatment is the duration and dosage of antibiotics and the resistance that bacteria develop after a long period of administration. With the aim of identifying mainly novel natural agents with antibacterial activity, the present study was undertaken to investigate the biological and phytochemical properties of extracts from the leaves Taraxacum officinale. The structural identification of compounds present in hexane (Hex) and ethyl acetate (AcOEt) extracts was performed by mass spectrometry (GC-MS) spectroscopic techniques and nuclear magnetic resonance (NMR) with the major compounds corresponding to different sesquiterpene lactones ( α -santonin, glabellin, arborescin, and estafiatin), monoterpene (9,10-dimethyltricycle [4...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
David R M Smith, F Christiaan K Dolk, Koen B Pouwels, Morag Christie, Julie V Robotham, Timo Smieszek
Objectives: To assess the appropriateness of prescribing systemic antibiotics for different clinical conditions in primary care, and to quantify 'ideal' antibiotic prescribing proportions in conditions for which antibiotic treatment is sometimes but not always indicated. Methods: Prescribing guidelines were consulted to define the appropriateness of antibiotic therapy for the conditions that resulted in antibiotic prescriptions between 2013 and 2015 in The Health Improvement Network (THIN) primary care database...
February 1, 2018: Journal of Antimicrobial Chemotherapy
Cindy L Amundsen, Yuko M Komesu, Christopher Chermansky, W Thomas Gregory, Deborah L Myers, Emily F Honeycutt, Sandip P Vasavada, John N Nguyen, Tracey S Wilson, Heidi S Harvie, Dennis Wallace
BACKGROUND: Urgency urinary incontinence (UUI) is a chronic condition for which sacral neuromodulation (SNM) (InterStim/Medtronic) and onabotulinumtoxinA (BTX) (BotoxA/Allergan) are utilized. These therapies have not been compared over extended time. OBJECTIVE: To compare UUI episodes (UUIE) over 24 mo following SNM or BTX. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, open-label, randomized, extension trial (February 2012-July 2016) at nine US medical centers involving 386 women with ≥6 UUIE over 3 d inadequately managed by medications...
February 23, 2018: European Urology
Kevser Özdemir, Sevil Şahin, Nebahat Özerdoğan, Alaattin Ünsal
Background/aim: This study aimed to determine the prevalence of urinary incontinence and to evaluate the relationship between urinary incontinence and quality of life in married women. Materials and methods: This is a cross-sectional study conducted among married women aged 20-49 years living in the vicinity of the Çökekler Community Clinic (Family Health Center) in Sakarya, Turkey, from 1 November 2011 to 15 April 2012. The study group consisted of 1161 women. Results: The frequency of urinary incontinence was 71...
February 23, 2018: Turkish Journal of Medical Sciences
Shu-Yu Wu, Hann-Chorng Kuo
AIMS: To investigate the real treatment outcomes after augmentation enterocystoplasty (AE) of patients with refractory neurogenic lower urinary tract dysfunction. METHODS: Retrospective follow-up in a single center. The videourodynamic data, renal function, incontinence grade, voiding pattern and management, clinical outcome, and complications were evaluated. RESULTS: Seventy-nine patients (62 men and 17 women) were included. The mean age at operation was 39...
February 21, 2018: Neurourology and Urodynamics
Christine M Khosropour, Teal R Bell, James P Hughes, Lisa E Manhart, Matthew R Golden
BACKGROUND: United States guidelines recommend azithromycin or doxycycline for chlamydia (CT) treatment. These therapies are similarly efficacious for urogenital infections when outcomes are measured 7-42 days following treatment, though doxycycline may be superior for rectal infections. Some investigators have suggested that persistent rectal infections may lead to autoinfection of the urogenital tract, potentially resulting in higher rates of recurrent infection in azithromycin-treated women...
November 16, 2017: Sexually Transmitted Diseases
Connie Wang, Alana L Christie, Philippe E Zimmern
INTRODUCTION: To study the evolution of type of presenting symptoms after mid-urethral sling (MUS) placement relative to the interval between placement and subsequent synthetic sling removal (SSR) for complication(s). METHODS: An IRB-approved, prospectively maintained database of women who underwent SSR was retrospectively reviewed for demographics, interval between MUS placement and SSR, history of chronic pain syndromes and recurrent urinary tract infections (RUTI), anti-incontinence and prolapse repairs, and MUS-related symptoms at presentation, including storage dysfunction, voiding dysfunction, RUTI, vaginal pain, non-vaginal pain, mesh exposure, and urinary incontinence (UI)...
February 21, 2018: Neurourology and Urodynamics
Carlos Manuel Ortiz-Mendoza
No abstract text is available yet for this article.
February 2018: Taiwanese Journal of Obstetrics & Gynecology
Michele Carlo Schiavi, Maria Grazia Porpora, Flaminia Vena, Giovanni Prata, Valentina Sciuga, Ottavia D'Oria, Chiara Di Tucci, Delia Savone, Natalia Aleksa, Andrea Giannini, Maria Paola Nusiner, Marzio Angelo Zullo, Ludovico Muzii, Pierluigi Benedetti Panici
OBJECTIVE: The aim of this study is to assess the efficacy of orally administered combination of hyaluronic acid (HA), chondroitin sulfate (CS), curcumin, and quercetin for the prevention of postcoital recurrent urinary tract infection (UTI) in reproductive age women. METHODS: Ninety-eight consecutive patients in reproductive age affected by UTI were considered for the study. All 98 patients received a combination of HA, CS, curcumin, and quercetin two tablets per diem for the first month and one tablet every day for the next 5 months...
January 31, 2018: Female Pelvic Medicine & Reconstructive Surgery
Suhanya Duraiswamy, Jacqueline L Y Chee, Siyi Chen, Enjun Yang, Kristin Lees, Swaine L Chen
Urinary tract infections (UTIs) are a major infection of humans, particularly affecting women. Recurrent UTIs can cause significant discomfort and expose patients to high levels of antibiotic use, in turn contributing to the development of higher antibiotic resistance rates. Most UTIs are caused by uropathogenic Escherichia coli , which are able to form intracellular collections (termed intracellular bacterial communities (IBCs)) within the epithelial cells lining the bladder lumen. IBCs are seen in both infected mice and humans and are a potential cause for recurrent UTI...
January 29, 2018: Infection and Immunity
Linda Brubaker, Cassandra Carberry, Rahel Nardos, Charelle Carter-Brooks, Jerry L Lowder
No abstract text is available yet for this article.
January 24, 2018: Female Pelvic Medicine & Reconstructive Surgery
Julisa Chamorro Lascasas Ribalta, Mariana Vendramin Mateussi, Neila Maria de Góis Speck
OBJECTIVE:  A vulvar squamous intraepithelial lesion is deemed to be a preceding lesion to vulvar cancer, especially in women aged under 40 years, holders of an acquired or idiopathic immunosuppression. Several treatments have been used to treat these lesions. One of the aesthetically acceptable therapeutic methods is the CO2 laser vaporization. METHODS:  In a transversal study, 46 records of immunosuppressed women bearing a vulvar low grade and/or high grade squamous intraepithelial lesion were selected out of the retrospective analysis, computing age, date of record, date of vulvar lesion treatment with CO2 laser, the time elapsed between the first and the last visit (in months), the number of visits, the presence or absence of condylomatous lesions in other female lower genital tract sites and whether or not recurrences and persistence of intraepithelial lesions have been noticed during the follow-up...
January 2018: Revista Brasileira de Ginecologia e Obstetrícia
Janaki Kannan Iyer, Alexia Dickey, Parvaneh Rouhani, Anil Kaul, Nirmal Govindaraju, Raj Narain Singh, Rashmi Kaul
About 25-44% of women will experience at least one episode of recurrent UTI and the causative agent in over 70% of UTI cases is uropathogenic Escherichia coli (UPEC). UPEC cause recurrent UTI by evading the bladder's innate immune system through internalization into the bladder epithelium where antibiotics cannot reach or be effective. Thus, it is important to develop novel therapeutics to eliminate these intracellular pathogens. Nanodiamonds (NDs) are biocompatible nanomaterials that serve as promising candidates for targeted therapeutic applications...
2018: PloS One
Sarah A Robertson, Peck-Yin Chin, Joseph G Femia, Hannah M Brown
Cytokines in the reproductive tract environment at conception mediate a dialogue between the embryo and maternal tissues to profoundly influence embryo development and implantation success. Through effects on gene expression and the cell stress response, cytokines elicit an epigenetic impact with consequences for placental development and fetal growth, which in turn affect metabolic phenotype and long-term health of offspring. There is substantial evidence demonstrating that pro-survival cytokines, such as GM-CSF, CSF1, LIF, HB-EGF and IGFII, support embryos to develop optimally...
February 2018: Journal of Reproductive Immunology
Gemma Nightingale, Qasem Shehab, Chandrakumaran Kandiah, Lorraine Rush, Clare Rowe-Jones, Christian H Phillips
OBJECTIVE: To determine whether sexual dysfunction in women with recurrent urinary tract infections (RUTI) improved following treatment with intravesical Hyaluronic Acid (HA) instillations. STUDY DESIGN: Ethical approval was obtained for a prospective study to be performed. Patients referred for bladder instillations to treat RUTI, and who were sexually active, were recruited to the study. A selection of validated questionnaires (ICIQ-UI, ICIQ-VS, FSDS-R, ICIQ-FLUTS, O'Leary/Sant and PGI-I) were completed at baseline, three, six and 12 months after initiation of treatment with bladder instillations...
December 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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