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https://www.readbyqxmd.com/read/29932498/tidal-breathing-parameters-measured-by-structured-light-plethysmography-in-children-aged-2-12-years-recovering-from-acute-asthma-wheeze-compared-with-healthy-children
#1
Hamzah Hmeidi, Shayan Motamedi-Fakhr, Edward K Chadwick, Francis J Gilchrist, Warren Lenney, Richard Iles, Rachel C Wilson, John Alexander
Measurement of lung function can be difficult in young children. Structured light plethysmography (SLP) is a novel, noncontact method of measuring tidal breathing that monitors displacement of the thoraco-abdominal wall. SLP was used to compare breathing in children recovering from an acute exacerbation of asthma/wheeze and an age-matched cohort of controls. Children aged 2-12 years with acute asthma/wheeze (n = 39) underwent two 5-min SLP assessments, one before bronchodilator treatment and one after. SLP was performed once in controls (n = 54)...
June 2018: Physiological Reports
https://www.readbyqxmd.com/read/29926556/optimal-bronchodilation-for-copd-patients-are-all-long-acting-%C3%AE-%C3%A2-agonist-long-acting-muscarinic-antagonists-the-same
#2
REVIEW
Marc Miravitlles, Seungjae Baek, Vatsal Vithlani, Rahul Lad
Bronchodilators provide improvements in lung function and reductions in symptoms and exacerbations, and are the mainstay of pharmacological management of chronic obstructive pulmonary disease (COPD). The Global Initiative for Chronic Obstructive Lung Disease strategy recommends the use of a combination of long-acting β₂-agonist/long-acting muscarinic antagonists (LABA/LAMA) as the first-line treatment option in the majority of symptomatic patients with COPD. This review provides an indirect comparison of available LABA/LAMA fixed-dose combinations (FDCs) through discussion of important efficacy and safety data from the key literature, with the objective of providing physicians with a framework for informed decision-making...
June 19, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29924458/current-controversies-in-the-stepping-up-and-stepping-down-of-inhaled-therapies-for-copd-at-the-patient-level
#3
REVIEW
Jose Luis Lopez-Campos, Laura Carrasco Hernández, Xavier Muñoz, Víctor Bustamante, Esther Barreiro
The implementation of potential new step-up or step-down treatment recommendations in response to current guidelines is one of the main challenges currently faced in actual daily practice settings. In the present narrative review, we aim to discuss the relevance of these step-up and step-down proposals at the patient level in daily clinical practice. In particular, we aim to review the challenges associated with inhaled maintenance therapy for chronic obstructive pulmonary disease (COPD) in four clinical scenarios...
June 20, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29922045/patient-considerations-in-the-treatment-of-copd-focus-on-the-new-combination-inhaler-fluticasone-furoate-umeclidinium-vilanterol
#4
REVIEW
Antonio Molino, Giovanna Calabrese, Mauro Maniscalco
The pharmacological treatment for stable COPD is based on the use of inhaled bronchodilators (long-acting muscarinic receptor antagonists and long-acting beta-2 adrenoceptor agonists) and inhaled corticosteroids. The use of triple inhaled therapy is recommended to selected patients with COPD. Among the various inhaler combinations in triple therapy, a new combination by fluticasone furoate, umeclidinium, and vilanterol is available for COPD patients. Recently, a large clinical trial using this combination has been published, resulting in a reduction in exacerbation rate in COPD patients...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29914544/a-phase-iia-proof-of-concept-placebo-controlled-randomized-double-blind-crossover-single-dose-clinical-trial-of-a-new-class-of-bronchodilator-for-acute-asthma
#5
Veronica Swystun, Francis H Y Green, John H Dennis, Emmanouil Rampakakis, Gurkeet Lalli, Morenike Fadayomi, Andrea Chiu, Grishma Shrestha, Sharif Galal El Shahat, David Evan Nelson, Tamer Y El Mays, Cora A Pieron, Richard Leigh
BACKGROUND: This study evaluates a novel bronchodilator, S1226, for its efficacy in reversing allergen-induced bronchoconstriction in subjects with mild, allergic asthma. S1226 is a new class of bronchodilator that is an aerosol/vapor/gas mixture combining pharmacological and biophysical principles for a novel mode of action. It contains a potent bronchodilator gas (carbon dioxide or CO2 ) and nebulized perflubron (a synthetic surfactant possessing mucolytic properties). It has demonstrated rapid reversal of allergen-induced bronchoconstriction in an ovine study model...
June 18, 2018: Trials
https://www.readbyqxmd.com/read/29909244/change-in-viral-bronchiolitis-management-in-hospitals-in-the-uk-after-the-publication-of-nice-guideline
#6
Rachael Barr, Elliott J Carande, Andrew J Pollard, Simon B Drysdale
BACKGROUND: Viral bronchiolitis is one of the most common causes of hospitalisation in young infants. It has previously been shown that many United Kingdom (UK) hospital Trusts were not compliant with many aspects of the National Institute for Health and Care Excellence (NICE) bronchiolitis guideline prior to its publication. OBJECTIVES: This study aimed to investigate changes in the management of bronchiolitis by hospital Trusts between 2015 (before NICE guideline publication) and 2017, after publication...
June 12, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29909073/changes-in-the-breath-sound-spectrum-with-bronchodilation-in-children-with-asthma
#7
Mariko Nukaga, Hideyuki Tabata, Mayumi Enseki, Kota Hirai, Hiroyuki Furuya, Masahiko Kato, Hiroyuki Mochizuki
BACKGROUND: Breath sound parameters have been suggested to be new biomarkers of airway function in patients with asthma. METHODS: We investigated the effect of bronchodilation on breath sound parameters in sixty-four children (mean age, 8.9 years; range, 6-16 years) using a breath sound analyzer. The breath sound parameters included frequency limiting 50% and 99% of the power spectrum (F50 and F99 ), roll-off from 600-1200 Hz (slope), and spectrum curve indices such as the ratios of the third and fourth power area to the total area of the power spectrum (P3 /PT and P4 /PT ), total area under the curve (A3 /AT and B4 /AT ), and the ratio of power and frequency at 50% and 75% of the highest frequency of the power spectrum (RPF75 and RPF50 )...
June 13, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29908154/an-integrative-transcriptomic-and-metabolomic-study-of-lung-function-in-asthmatic-children
#8
Rachel S Kelly, Bo L Chawes, Kevin Blighe, Yamini V Virkud, Damien C Croteau-Chonka, Michael J McGeachie, Clary B Clish, Kevin Bullock, Juan C Celedón, Scott T Weiss, Jessica A Lasky-Su
BACKGROUND: Single-omic analyses have provided some insight into the basis of lung function in asthmatic children, but the underlying biological pathways are still poorly understood. METHODS: Weighted gene co-expression network analysis (WGCNA) was used to identify modules of co-regulated gene transcripts and metabolites in blood, among 325 children with asthma from the 'Genetic Epidemiology of Asthma in Costa Rica' study. The biology of modules associated with lung function; as measured by FEV1 , FEV1 /FVC-ratio, bronchodilator response, and airway responsiveness to methacholine, was explored...
June 13, 2018: Chest
https://www.readbyqxmd.com/read/29907212/predicting-the-response-to-a-bronchodilator-in-patients-with-airflow-obstruction-and-lung-cancer
#9
Kazuhiro Ueda, Junichi Murakami, Toshiki Tanaka, Kumiko Yoshida, Taiga Kobayashi, Kimikazu Hamano
BACKGROUND: The aim of the present study was to clarify the predictors of the response of patients with resectable lung cancer and untreated airflow obstruction to tiotropium, an antimuscarinic bronchodilator. METHODS: Tiotropium was administered to 29 preoperative patients with untreated airflow obstruction. The forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1 ) were measured before and after the introduction of tiotropium. The response to tiotropium was determined based on the percentage gain in the FEV1 ...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906501/repurposing-drugs-as-inhaled-therapies-in-asthma
#10
Sandra D Anderson
For the first 40 years of the 20th century treatment for asthma occurred in response to an asthma attack. The treatments were given by injection or orally and included the adrenergic agonists adrenalin/epinephrine and ephedrine and a phosphodiesterase inhibitor theophylline. Epinephrine became available as an aerosol in 1930. After 1945, isoprenaline, a non-selective beta agonist, became available for oral use but it was most widely used by inhalation. Isoprenaline was short-acting with unwanted cardiac effects...
June 12, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29903861/combined-value-of-exhaled-nitric-oxide-and-blood-eosinophils-in-chronic-airway-disease-the-copenhagen-general-population-study
#11
Yunus Çolak, Shoaib Afzal, Børge G Nordestgaard, Jacob L Marott, Peter Lange
We investigated whether the combination of increased fraction of exhaled nitric oxide (FeNO) level and blood eosinophil count had an additive value in chronic airway disease in the general population.We included 4677 individuals aged 20-100 years from the Copenhagen General Population Study. Based on pre- and post-bronchodilator spirometry, self-reported asthma, and smoking history, participants were subdivided into:healthy never-smokers (n=1649), healthy ever-smokers (n=1581), asthma (n=449), chronic obstructive pulmonary disease (COPD) (n=404), asthma-COPD overlap (ACO) (n=138), and non-specific airflow limitation (n=456)...
June 14, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29900310/data-on-the-lignosus-rhinocerotis-water-soluble-sclerotial-extract-affecting-intracellular-calcium-level-in-rat-dorsal-root-ganglion-cells
#12
Mei-Kee Lee, Paul Millns, Yvonne Mbaki, Szu-Ting Ng, Chon-Seng Tan, Kuan-Hon Lim, Sue-Mian Then, Suresh Kumar Mohankumar, Kang-Nee Ting
The data in this article contain supporting evidence for the research manuscript entitled "Bronchodilator effects of Lignosus rhinocerotis extract on rat isolated airways is linked to the blockage of calcium entry" by Lee et al. (2018) [1]. The data were obtained by calcium imaging technique with fluorescent calcium indicator dyes, Fura 2-AM, to visualize calcium ion movement in the rat dorsal ganglion (DRG) cells. The effects of L. rhinocerotis cold water extract (CWE1 ) on intracellular calcium levels in the DRG cells were presented...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29893029/impact-of-hypertonic-saline-on-hospitalization-rate-in-infants-with-acute-bronchiolitis-a-meta-analysis
#13
Linjie Zhang, Carlos B Gunther, Ozeia S Franco, Terry P Klassen
AIM: This meta-analysis aimed to assess the efficacy of nebulized hypertonic saline (HS) on the rate of hospitalization in infants with acute bronchiolitis in the Emergency Department (ED) setting. METHOD: We searched PubMed, Virtual Health Library-BVS and Cochrane CENTRAL from inception until January 31, 2018. We selected randomized trials that compared nebulized HS with normal saline (NS) or standard care in children up to 24 months of age with acute bronchiolitis in the ED setting...
June 12, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29892540/black-lungs-and-big-nodes-a-case-of-airway-anthracosis-with-bronchial-anthracofibrosis
#14
S R Devarajan, N Zarrin-Khameh, P Alapat
We present a case of a 76 year-old, non-smoking Honduran female who was referred to our clinic for years of persistent dry cough. Cardiac evaluation was unremarkable. She denied symptoms of heartburn, allergic rhinitis, and there was no personal or family history of asthma. Her physical exam demonstrated wheezing over the right mid-posterior chest. Spirometry was within normal limits. CT-imaging of the chest demonstrated right middle lobe bronchus and lingular segmental bronchus narrowing with bibasilar atelectasis and mild interlobular septal thickening with prominent mediastinal adenopathy...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29892192/increased-urinary-l-histidine-in-patients-with-asthma-copd-overlap-a-pilot-study
#15
Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Kyung Ho Kang, Chin Kook Rhee, Seoung Ju Park, Adnan Khan, Jinhyuk Na, Youngja H Park, Jae Jeong Shim
Purpose: Asthma-COPD overlap (ACO) is heterogeneous in nature and requires a unified diagnostic approach. We investigated the urinary levels of l-histidine, a precursor of histamine related to inflammatory responses, as a new candidate biomarker for diagnosing this condition. Patients and methods: We performed a prospective multicenter cohort study with retrospective analysis of 107 patients, who were divided into three groups: asthma, COPD, and ACO, according to the Spanish guidelines algorithm...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29887979/determinants-of-persistent-asthma-in-young-adults
#16
Lisbet Krogh Traulsen, Anders Halling, Jesper Bælum, Jesper Rømhild Davidsen, Martin Miller, Øyvind Omland, David Sherson, Torben Sigsgaard, Trine Thilsing, Gert Thomsen, Lars Rauff Skadhauge
Objective: The aim of the study was to evaluate determinants for the prognosis of asthma in a population-based cohort of young adults. Design: The study was a nine-year clinical follow up of 239 asthmatic subjects from an enriched population-based sample of 1,191 young adults, aged 20-44 years, who participated in an interviewer-administered questionnaire and clinical examination at baseline in 2003-2006. From the interview, an asthma score was generated as the simple sum of affirmative answers to five main asthma-like symptoms in order to analyse symptoms of asthma as a continuum...
2018: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29884246/combining-dual-bronchodilation-and-%C3%AE-blockade-in-patients-with-an-overlap-between-copd-and-cardiovascular-diseases
#17
EDITORIAL
Mario Cazzola, Maria Gabriella Matera
No abstract text is available yet for this article.
June 2018: Chest
https://www.readbyqxmd.com/read/29874098/longitudinal-phenotypes-and-mortality-in-preserved-ratio-impaired-spirometry-in-the-copdgene-study
#18
Emily S Wan, Spyridon Fortis, Elizabeth A Regan, John Hokanson, MeiLan K Han, Richard Casaburi, Barry J Make, James D Crapo, Dawn L DeMeo, Edwin K Silverman
Rationale/Objective Increasing awareness of the prevalence and significance of Preserved Ratio Impaired Spirometry (PRISm), alternatively known as "restrictive" or "GOLD-Unclassified" spirometry, has expanded the body of knowledge on cross-sectional risk factors. However, longitudinal studies of PRISm remain limited. Methods/Measurements Current and former smokers, age 45-80, were enrolled in COPDGene (Phase 1, 2008-2011) and returned for a 5-year follow up (Phase 2, 2012-2016). Subjects completed questionnaires, spirometry, chest CT scans, and 6-minute walk tests at both study visits...
June 6, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29873642/-lung-and-heart-interaction-chronic-obstructive-pulmonary-disease-and-ischemic-heart-disease
#19
Sara Roversi, Leonardo M Fabbri
The interaction between the lung and the heart is a vast, complex, and fascinating topic and, from a clinical point of view, disorders of the one often influence and promote disorders of the other. This is especially true for chronic diseases, with chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD) representing a classic example. Epidemiologic data indicate that cardiovascular diseases are frequent in patients with COPD, and vice versa. Accordingly, rates of IHD in COPD vary from 4% up to 60%, while, on the other hand, COPD has been reported in up to 30% of patients with coronary artery disease...
March 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29873189/prevalence-and-features-of-asthma-copd-overlap-in-the-u-s-2007-2012
#20
Angelico Mendy, Erick Forno, Theophile Niyonsenga, Ryan Carnahan, Janvier Gasana
BACKGROUND: Perceived to be distinct, asthma and chronic obstructive pulmonary disease (COPD) can co-exist and potentially have a worse prognosis than the separate diseases. Yet, little is known about the exact prevalence and the characteristics of the Asthma-COPD overlap (ACO) in the U.S. POPULATION: <AbstractText Label="AIMS" NlmCategory="OBJECTIVE">To determine ACO prevalence in the U.S., identify ACO predictors, examine ACO association with asthma and COPD severity, and describe distinctive spirometry and laboratory features of ACO...
June 5, 2018: Clinical Respiratory Journal
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