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https://www.readbyqxmd.com/read/27845776/proliferation-rates-and-gene-expression-profiles-in-human-lymphoblastoid-cell-lines-from-patients-with-depression-characterized-in-response-to-antidepressant-drug-therapy
#1
J Breitfeld, C Scholl, M Steffens, K Brandenburg, K Probst-Schendzielorz, O Efimkina, D Gurwitz, M Ising, F Holsboer, S Lucae, J C Stingl
The current therapy success of depressive disorders remains in need of improvement due to low response rates and a delay in symptomatic improvement. Reliable functional biomarkers would be necessary to predict the individual treatment outcome. On the basis of the neurotrophic hypothesis of antidepressant's action, effects of antidepressant drugs on proliferation may serve as tentative individual markers for treatment efficacy. We studied individual differences in antidepressant drug effects on cell proliferation and gene expression in lymphoblastoid cell lines (LCLs) derived from patients treated for depression with documented clinical treatment outcome...
November 15, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27796421/hdac7-is-overexpressed-in-human-diabetic-islets-and-impairs-insulin-secretion-in-rat-islets-and-clonal-beta-cells
#2
Mahboubeh Daneshpajooh, Karl Bacos, Madhusudhan Bysani, Annika Bagge, Emilia Ottosson Laakso, Petter Vikman, Lena Eliasson, Hindrik Mulder, Charlotte Ling
AIMS/HYPOTHESIS: Pancreatic beta cell dysfunction is a prerequisite for the development of type 2 diabetes. Histone deacetylases (HDACs) may affect pancreatic endocrine function and glucose homeostasis through alterations in gene regulation. Our aim was to investigate the role of HDAC7 in human and rat pancreatic islets and clonal INS-1 beta cells (INS-1 832/13). METHODS: To explore the role of HDAC7 in pancreatic islets and clonal beta cells, we used RNA sequencing, mitochondrial functional analyses, microarray techniques, and HDAC inhibitors MC1568 and trichostatin A...
January 2017: Diabetologia
https://www.readbyqxmd.com/read/27793772/tcf7l2-mediates-the-cellular-and-behavioral-response-to-chronic-lithium-treatment-in-animal-models
#3
Katarzyna Misztal, Nikola Brozko, Andrzej Nagalski, Lukasz M Szewczyk, Marta Krolak, Katarzyna Brzozowska, Jacek Kuznicki, Marta B Wisniewska
The mechanism of lithium's therapeutic action remains obscure, hindering the discovery of safer treatments for bipolar disorder. Lithium can act as an inhibitor of the kinase GSK3α/β, which in turn negatively regulates β-catenin, a co-activator of LEF1/TCF transcription factors. However, unclear is whether therapeutic levels of lithium activate β-catenin in the brain, and whether this activation could have a therapeutic significance. To address this issue we chronically treated mice with lithium. Although the level of non-phospho-β-catenin increased in all of the brain areas examined, β-catenin translocated into cellular nuclei only in the thalamus...
October 25, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27792933/association-between-the-tcf7l2-polymorphism-and-colorectal-cancer-does-not-differ-by-diabetes-and-obesity-statuses
#4
Hyun-Jeong Shim, Ran Lee, Min-Ho Shin, Hee-Nam Kim, Sun-Seog Kweon
This study evaluated the association between polymorphism in a newly identified locus, rs11196172, located in transcription factors 7-like 2 (TCF7L2) and colorectal cancer (CRC) risk according to diabetes and obesity statuses. A study enrolled 6138 CRC patients and 4367 community controls. The adjusted odds ratios (aORs) with age, sex, smoking, and body mass index of the A allele, compared with the G allele, was 1.08 (95% CI 1.01-1.16). The significantly higher risk of CRC with the A allele remained after adjusting for diabetic status (aOR 1...
December 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27777306/a-critical-role-for-%C3%AE-catenin-in-modulating-levels-of-insulin-secretion-from-%C3%AE-cells-by-regulating-actin-cytoskeleton-and-insulin-vesicle-localization
#5
Brie Sorrenson, Emmanuelle Cognard, Kathryn L Lee, Waruni C Dissanayake, Yanyun Fu, Weiping Han, William E Hughes, Peter R Shepherd
The processes regulating glucose-stimulated insulin secretion (GSIS) and its modulation by incretins in pancreatic β-cells are only partly understood. Here we investigate the involvement of β-catenin in these processes. Reducing β-catenin levels using siRNA knockdown attenuated GSIS in a range of β-cell models and blocked the ability of GLP-1 agonists and the depolarizing agent KCl to potentiate this. This could be mimicked in both β-cell models and isolated islets by short-term exposure to the β-catenin inhibitory drug pyrvinium...
October 24, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27761963/celecoxib-and-2-5-dimethylcelecoxib-inhibit-intestinal-cancer-growth-by-suppressing-the-wnt-%C3%AE-catenin-signaling-pathway
#6
Issei Egashira, Fumi Takahashi-Yanaga, Risa Nishida, Masaki Arioka, Kazunobu Igawa, Katsuhiko Tomooka, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Yusaku Nakabeppu, Takanari Kitazono, Toshiyuki Sasaguri
We previously reported that celecoxib, a selective COX-2 inhibitor, strongly inhibited human colon cancer cell proliferation by suppressing the Wnt/β-catenin signaling pathway. 2,5-Dimethylcelecoxib (DM-celecoxib), a celecoxib analog that does not inhibit COX-2, has also been reported to have an antitumor effect. In the present study, we elucidated whether DM-celecoxib inhibits intestinal cancer growth, and its underlying mechanism of action. First, we compared the effect of DM-celecoxib with that of celecoxib on the human colon cancer cell lines HCT-116 and DLD-1...
October 20, 2016: Cancer Science
https://www.readbyqxmd.com/read/27758844/impact-of-the-tcf7l2-genotype-on-risk-of-hypoglycaemia-and-glucagon-secretion-during-hypoglycaemia
#7
Peter L Kristensen, Ulrik Pedersen-Bjergaard, Rikke Due-Andersen, Thomas Høi-Hansen, Lise Grimmeshave, Valeriya Lyssenko, Leif Groop, Jens J Holst, Allan A Vaag, Birger Thorsteinsson
INTRODUCTION: In healthy carriers of the T allele of the transcription factor 7-like 2 (TCF7L2), fasting plasma glucagon concentrations are lower compared with those with the C allele. We hypothesised that presence of the T allele is associated with a diminished glucagon response during hypoglycaemia and a higher frequency of severe hypoglycaemia (SH) in type 1 diabetes (T1DM). MATERIAL AND METHODS: This is a post hoc study of an earlier prospective observational study of SH and four mechanistic studies of physiological responses to hypoglycaemia...
November 2016: Endocrine Connections
https://www.readbyqxmd.com/read/27755946/tcf7l2-and-ccnd1-polymorphisms-and-its-association-with-colorectal-cancer-in-mexican-patients
#8
M A Rosales-Reynoso, A R Arredondo-Valdez, C I Juárez-Vázquez, L I Wence-Chavez, P Barros-Núñez, M P Gallegos-Arreola, S E Flores-Martínez, M C Morán-Moguel, J Sánchez-Corona
Accumulative evidence suggests that alterations due to mutations or genetic polymorphisms in the TCF7L2 and CCND1 genes, which are components of the Wnt signaling pathway, contributes to carcinogenesis. The present study was designated to clarify whether common single nucleotide polymorphisms (SNPs) of the transcription factor 7- like 2 (TCF7L2) and cyclin D1 (CCND1) genes are associated with colorectal cancer risk in Mexican patients. A case-control study including 197 colorectal cancer patients and 100 healthy subjects was conducted in a Mexican population...
September 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27742678/mir-181a-5p-regulates-3t3-l1-cell-adipogenesis-by-targeting-smad7-and-tcf7l2
#9
Dan Ouyang, Lifeng Xu, Lihua Zhang, Dongguang Guo, Xiaotong Tan, Xiaofang Yu, Junjie Qi, Yaqiong Ye, Qihong Liu, Yongjiang Ma, Yugu Li
MicroRNAs are highly conserved non-coding small RNAs participating in almost all kinds of biological activities. MiR-181a has been reported to be involved in the differentiation of porcine primary preadipocytes, but the profound effect of miR-181a-5p on 3T3-L1 adipocyte differentiation and proliferation is still unclear. In this study, we found that supplementation of miR-181a-5p in 3T3-L1 cells significantly promoted the adipogenesis and inhibited cell proliferation with increased expression of adipogenic marker genes including peroxisome proliferator-activated receptor gamma (Pparγ), CCAAT/enhancer-binding protein alpha (C/ebpα), fatty acid-binding protein 4 (Fabp4), and Adiponectin, accompanied by an accumulation of lipid droplet, an increase of triglyceride content, and a decrease of cell proliferation...
October 14, 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/27738320/association-of-transcription-factor-7-like-2-gene-polymorphisms-with-breast-cancer-risk-in-northwest-chinese-women
#10
Weili Min, Xinghan Liu, Ye Lu, Zhuoqing Gong, Meng Wang, Shuai Lin, Huafeng Kang, Tianbo Jin, Xijing Wang, Xiaobin Ma, Kang Liu, Cong Dai, Yi Zheng, Shanli Li, Qingyong Ma, Zhijun Dai
Genetic variations in transcription factor 7-like 2 (TCF7L2) are associated with cancer risk. This study was conducted to establish the relationship between TCF7L2 polymorphisms (rs1225404, rs7003146, and rs7903146) and clinical features and risk of breast cancer in northwest Chinese Han women. In this study, three polymorphisms of TCF7L2 (rs1225404, rs7003146, and rs7903146) were genotyped in 458 patients with breast cancer and 500 healthy controls using the Sequenom MassARRAY-iPLEX system. We evaluated the associations between the polymorphisms and breast cancer using odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs)...
October 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27721485/the-anti-hyperglycemic-efficacy-of-a-lipid-lowering-drug-daming-capsule-and-the-underlying-signaling-mechanisms-in-a-rat-model-of-diabetes-mellitus
#11
Yong Zhang, Xiaoguang Li, Jiamin Li, Qingwei Zhang, Xiaohui Chen, Xin Liu, Yue Zhang, Haiying Zhang, Huan Yang, Yingying Hu, Xianxian Wu, Xin Li, Jiaming Ju, Baofeng Yang
Diabetes mellitus (DM) is a metabolic disorder manifested by hyperglycemia. Daming Capsule (DMC), a combination of traditional Chinese herbs, is used clinically as a lipid-lowering drug. This study was designed to evaluate if DMC possesses an anti-hyperglycemic effect and to elucidate the underlying mechanisms. Compared to diabetic rats, the rats received DMC (200 mg/kg/d) had significantly lower blood lipid and glucose levels. DMC markedly restored the decreased secretion of GLP-1 and GIP as well as the coding gene GCG and GIP in ileum...
October 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27709738/wnt-%C3%AE-catenin-signaling-regulates-abcc3-mrp3-transporter-expression-in-colorectal-cancer
#12
Minoru Kobayashi, Ryo Funayama, Shinobu Ohnuma, Michiaki Unno, Keiko Nakayama
We determined the gene expression profiles for 48 ATP binding cassette (ABC) transporters in matched colon cancer and normal colon tissues in order to provide insight into the mechanisms underlying expression of transporters related to colon carcinogenesis. The expression of ABCB1, ABCC1, ABCC2, ABCC3, and ABCG2 was altered in association with colon carcinogenesis. Among these transporters, the expression of ABCC3 was repressed by Wnt signaling pathway in colon cancer cell lines. Knockdown of the pathway components transcription factor 7-like 2 (TCF7L2) or β-catenin thus increased ABCC3 expression, whereas activation of Wnt signaling with inhibitors of glycogen synthase kinase-3β (GSK-3β) reduced it...
October 6, 2016: Cancer Science
https://www.readbyqxmd.com/read/27706609/correlation-of-the-tcf7l2-rs7903146-polymorphism-with-an-enhanced-risk-of-type-2-diabetes-mellitus-a-meta-analysis
#13
Y Guan, L H Yan, X Y Liu, X Y Zhu, S Z Wang, L M Chen
Increasing evidence has demonstrated that a transcription factor 7-like 2 (TCF7L2) polymorphism (rs7903146) is significantly associated with type 2 diabetes mellitus (T2DM); however, limited sample size and variance of ethnicity in the studies investigating this association have led to conflicting reports regarding its role. Therefore, a comprehensive meta-analysis was conducted to quantitatively assess the association between the TCF7L2 polymorphism (rs7903146) and T2DM including published case-control studies in global populations...
August 26, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27693749/wnt-signaling-promotes-hindgut-fate-commitment-through-regulating-multi-lineage-genes-during-hesc-differentiation
#14
Xiujuan Zhang, Ying Chen, Ying Ye, Jianfeng Wang, Hong Wang, Guohong Yuan, Zhe Lin, Yihui Wu, Yan Zhang, Xinhua Lin
Wnt signaling plays essential roles in both embryonic pattern formation and postembryonic tissue homoestasis. High levels of Wnt activity repress foregut identity and facilitate hindgut fate through forming a gradient of Wnt signaling activity along the anterior-posterior axis. Here, we examined the mechanisms of Wnt signaling in hindgut development by differentiating human embryonic stem cells (hESCs) into the hindgut progenitors. We observed severe morphological changes when Wnt signaling was blocked by using Wnt antagonist Dkk1...
September 29, 2016: Cellular Signalling
https://www.readbyqxmd.com/read/27675057/using-single-nucleotide-polymorphisms-in-tcf7l2-and-il-6-to-predict-brain-metastasis
#15
C O Abana, B Bingham, T Koyama, R T Pilarski, J H Cho, A J Graves, F Xia, A B Chakravarthy
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27668865/tcf7l2-tcf4-transcriptional-repressor-function-requires-hdac-activity-in-the-developing-vertebrate-cns
#16
Hui Wang, Michael P Matise
The generation of functionally distinct neuronal subtypes within the vertebrate central nervous system (CNS) requires the precise regulation of progenitor gene expression in specific neuronal territories during early embryogenesis. Accumulating evidence has implicated histone deacetylase (HDAC) proteins in cell specification, proliferation, and differentiation in diverse embryonic and adult tissues. However, although HDAC proteins have shown to be expressed in the developing vertebrate neural tube, their specific role in CNS neural progenitor fate specification remains unclear...
2016: PloS One
https://www.readbyqxmd.com/read/27650258/a-multianalytical-approach-to-evaluate-the-association-of-55-snps-in-28-genes-with-obesity-risk-in-north-indian-adults
#17
Apurva Srivastava, Balraj Mittal, Jai Prakash, Pranjal Srivastava, Nimisha Srivastava, Neena Srivastava
OBJECTIVES: The aim of the study was to investigate the association of 55 SNPs in 28 genes with obesity risk in a North Indian population using a multianalytical approach. METHODS: Overall, 480 subjects from the North Indian population were studied using strict inclusion/exclusion criteria. SNP Genotyping was carried out by Sequenom Mass ARRAY platform (Sequenom, San Diego, CA) and validated Taqman(®) allelic discrimination (Applied Biosystems(®) ). Statistical analyses were performed using SPSS software version 19...
September 21, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27639123/genetic-variations-in-tcf7l2-influence-therapeutic-response-to-sulfonylureas-in-indian-diabetics
#18
Dipali Dhawan, Harish Padh
Sulfonylureas are widely used to treat type 2 diabetes, with considerable inter-individual variation in the hypoglycaemic response to sulfonylureas. Genetic variants in the gene encoding for transcription factor-7-like 2 (TCF7L2) have been associated with type 2 diabetes. This study aimed to study the effect of variations in TCF7L2 on therapeutic response to sulfonylureas in Type 2 diabetes mellitus patients. The effect of TCF7L2 rs12255372, rs7903146 and rs4506565 genotypes on glycaemic response was observed in 250 diabetic patients treated with sulfonylureas and sulfonylureas along with metformin...
September 8, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27624071/aurora-kinase-a-overexpression-in-mouse-mammary-epithelium-induces-mammary-adenocarcinomas-harboring-genetic-alterations-shared-with-human-breast-cancer
#19
Warapen Treekitkarnmongkol, Hiroshi Katayama, Kazuharu Kai, Kaori Sasai, Jennifer Carter Jones, Jing Wang, Li Shen, Aysegul A Sahin, Mihai Gagea, Naoto T Ueno, Chad J Creighton, Subrata Sen
Recent data from The Cancer Genome Atlas analysis have revealed that Aurora kinase A (AURKA) amplification and overexpression characterize a distinct subset of human tumors across multiple cancer types. Although elevated expression of AURKA has been shown to induce oncogenic phenotypes in cells in vitro, findings from transgenic mouse models of Aurora-A overexpression in mammary glands have been distinct depending on the models generated. In the present study, we report that prolonged overexpression of AURKA transgene in mammary epithelium driven by ovine β-lactoglobulin promoter, activated through multiple pregnancy and lactation cycles, results in the development of mammary adenocarcinomas with alterations in cancer-relevant genes and epithelial-to-mesenchymal transition...
December 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27623948/an-alternative-effector-gene-at-the-type-2-diabetes-associated-tcf7l2-locus
#20
EDITORIAL
Martijn van de Bunt
No abstract text is available yet for this article.
November 2016: Diabetologia
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