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https://www.readbyqxmd.com/read/28916264/sidt2-transports-extracellular-dsrna-into-the-cytoplasm-for-innate-immune-recognition
#1
Tan A Nguyen, Blake R C Smith, Michelle D Tate, Gabrielle T Belz, Marilou H Barrios, Kirstin D Elgass, Alexandra S Weisman, Paul J Baker, Simon P Preston, Lachlan Whitehead, Alexandra Garnham, Rachel J Lundie, Gordon K Smyth, Marc Pellegrini, Meredith O'Keeffe, Ian P Wicks, Seth L Masters, Craig P Hunter, Ken C Pang
Double-stranded RNA (dsRNA) is a common by-product of viral infections and acts as a potent trigger of antiviral immunity. In the nematode C. elegans, sid-1 encodes a dsRNA transporter that is highly conserved throughout animal evolution, but the physiological role of SID-1 and its orthologs remains unclear. Here, we show that the mammalian SID-1 ortholog, SIDT2, is required to transport internalized extracellular dsRNA from endocytic compartments into the cytoplasm for immune activation. Sidt2-deficient mice exposed to extracellular dsRNA, encephalomyocarditis virus (EMCV), and herpes simplex virus 1 (HSV-1) show impaired production of antiviral cytokines and-in the case of EMCV and HSV-1-reduced survival...
September 7, 2017: Immunity
https://www.readbyqxmd.com/read/28912681/divergence-in-morris-water-maze-based-cognitive-performance-under-chronic-stress-is-associated-with-the-hippocampal-whole-transcriptomic-modification-in-mice
#2
Seung H Jung, Milene L Brownlow, Matteo Pellegrini, Ryan Jankord
Individual susceptibility determines the magnitude of stress effects on cognitive function. The hippocampus, a brain region of memory consolidation, is vulnerable to stressful environments, and the impact of stress on hippocampus may determine individual variability in cognitive performance. Therefore, the purpose of this study was to define the relationship between the divergence in spatial memory performance under chronically unpredictable stress and an associated transcriptomic alternation in hippocampus, the brain region of spatial memory consolidation...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28902069/antiinflammatory-strategies-in-intrahepatic-islet-transplantation-a-comparative-study-in-preclinical-models
#3
A Citro, E Cantarelli, S Pellegrini, E Dugnani, L Piemonti
BACKGROUND: The identification of pathway(s) playing a pivotal role in peritransplant detrimental inflammatory events represents the crucial step towards a better management and outcome of pancreatic islet transplanted patients. Recently, we candidate the CXCR1/2 inhibition as a relevant strategy in enhancing pancreatic islet survival after transplantation. METHODS: Here, the most clinically used antiinflammatory compounds (IL1-receptor antagonist, steroids and TNF-α inhibitor) alone or in combination with a CXCR1/2 inhibitor were evaluated in their ability to improve engraftment or delay graft rejection...
September 8, 2017: Transplantation
https://www.readbyqxmd.com/read/28900390/genetically-driven-enhancement-of-dopaminergic-transmission-affects-moral-acceptability-in-females-but-not-in-males-a-pilot-study
#4
Silvia Pellegrini, Sara Palumbo, Caterina Iofrida, Erika Melissari, Giuseppina Rota, Veronica Mariotti, Teresa Anastasio, Andrea Manfrinati, Rino Rumiati, Lorella Lotto, Michela Sarlo, Pietro Pietrini
Moral behavior has been a key topic of debate for philosophy and psychology for a long time. In recent years, thanks to the development of novel methodologies in cognitive sciences, the question of how we make moral choices has expanded to the study of neurobiological correlates that subtend the mental processes involved in moral behavior. For instance, in vivo brain imaging studies have shown that distinct patterns of brain neural activity, associated with emotional response and cognitive processes, are involved in moral judgment...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28899942/trz1-the-long-form-rnase-z-from-yeast-forms-a-stable-heterohexamer-with-endonuclease-nuc1-and-mutarotase
#5
Miao Ma, Ines Li de La Sierra Gallay, Noureddine Lazar, Olivier Pellegrini, Jean Lepault, Ciarán Condon, Dominique Durand, Herman van Tilbeurgh
Proteomic studies haves established that Trz1, Nuc1 and mutarotase form a complex in yeast. Trz1 is a b-lactamase type RNase composed of two b-lactamase type domains connected by a long linker that is responsible for the endonucleolytic cleavage at the 3'-end of tRNAs during the maturation process (RNase Z activity); Nuc1 is a dimeric mitochondrial nuclease involved in apoptosis, while mutarotase (encoded by YMR099C) catalyzes the conversion between the a- and b-configuration of glucose-6-phosphate. Using gel-filtration, SAXS and electron microscopy we demonstrated that Trz1, Nuc1 and mutarotase form a very stable heterohexamer, composed of two copies of each of the three subunits...
September 12, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28892329/leadership-is-crucial-to-establishing-safety-culture-reducing-adverse-events
#6
Carlos A Pellegrini
No abstract text is available yet for this article.
May 2017: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28887454/the-intestinal-phosphate-transporter-napi-iib-slc34a2-is-required-to-protect-bone-during-dietary-phosphate-restriction
#7
Thomas Knöpfel, Eva M Pastor-Arroyo, Udo Schnitzbauer, Denise V Kratschmar, Alex Odermatt, Giovanni Pellegrini, Nati Hernando, Carsten A Wagner
NaPi-IIb/Slc34a2 is a Na(+)-dependent phosphate transporter that accounts for the majority of active phosphate transport into intestinal epithelial cells. Its abundance is regulated by dietary phosphate, being high during dietary phosphate restriction. Intestinal ablation of NaPi-IIb in mice leads to increased fecal excretion of phosphate, which is compensated by enhanced renal reabsorption. Here we compared the adaptation to dietary phosphate of wild type (WT) and NaPi-IIb(-/-) mice. High phosphate diet (HPD) increased fecal and urinary excretion of phosphate in both groups, though NaPi-IIb(-/-) mice still showed lower urinary excretion than WT...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28885812/time-outs-and-their-role-in-improving-safety-and-quality-in-surgery
#8
Carlos A Pellegrini
No abstract text is available yet for this article.
June 2017: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28885796/joint-commission-releases-data-on-challenging-requirements-for-obs-practices
#9
Carlos A Pellegrini
No abstract text is available yet for this article.
July 2017: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28872636/high-resolution-multibeam-and-hydrodynamic-datasets-of-tidal-channels-and-inlets-of-the-venice-lagoon
#10
Fantina Madricardo, Federica Foglini, Aleksandra Kruss, Christian Ferrarin, Nicola Marco Pizzeghello, Chiara Murri, Monica Rossi, Marco Bajo, Debora Bellafiore, Elisabetta Campiani, Stefano Fogarin, Valentina Grande, Lukasz Janowski, Erica Keppel, Elisa Leidi, Giuliano Lorenzetti, Francesco Maicu, Vittorio Maselli, Alessandra Mercorella, Giacomo Montereale Gavazzi, Tiziano Minuzzo, Claudio Pellegrini, Antonio Petrizzo, Mariacristina Prampolini, Alessandro Remia, Federica Rizzetto, Marzia Rovere, Alessandro Sarretta, Marco Sigovini, Luigi Sinapi, Georg Umgiesser, Fabio Trincardi
Tidal channels are crucial for the functioning of wetlands, though their morphological properties, which are relevant for seafloor habitats and flow, have been understudied so far. Here, we release a dataset composed of Digital Terrain Models (DTMs) extracted from a total of 2,500 linear kilometres of high-resolution multibeam echosounder (MBES) data collected in 2013 covering the entire network of tidal channels and inlets of the Venice Lagoon, Italy. The dataset comprises also the backscatter (BS) data, which reflect the acoustic properties of the seafloor, and the tidal current fields simulated by means of a high-resolution three-dimensional unstructured hydrodynamic model...
September 5, 2017: Scientific Data
https://www.readbyqxmd.com/read/28870895/fluoride-induces-apoptosis-in-mammalian-cells-in-vitro-and-in-vivo-studies
#11
REVIEW
Daniel Araki Ribeiro, Caroline Margonato Cardoso, Veronica Quispe Yujra, Milena DE Barros Viana, Odair Aguiar, Luciana Pellegrini Pisani, Celina Tizuko Fujiyama Oshima
Apoptosis is genetically programmed cell death, an irreversible process of cell senescence with characteristic features different from other cellular mechanisms of death such as necrosis. In the last years, apoptosis has been extensively studied in the scientific literature, because it has been established that apoptosis plays a crucial role following the time course of chronic degenerative diseases, such as cancer. Thus, several researchers have strugged to detect what chemical agents are able to inter fere with the apoptotic process...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28869746/physiological-intensity-profile-exercise-load-and-performance-predictors-of-a-65-km-mountain-ultra-marathon
#12
Alessandro Fornasiero, Aldo Savoldelli, Damiano Fruet, Gennaro Boccia, Barbara Pellegrini, Federico Schena
The aims of the study were to describe the physiological profile of a 65-km (4000-m cumulative elevation gain) running mountain ultra-marathon (MUM) and to identify predictors of MUM performance. Twenty-three amateur trail-runners performed anthropometric evaluations and an uphill graded exercise test (GXT) for VO2max, ventilatory thresholds (VTs), power outputs (PMax, PVTs) and heart rate response (HRmax, HR@VTs). Heart rate (HR) was monitored during the race and intensity was expressed as: Zone I (<VT1), Zone II (VT1-VT2), Zone III (>VT2) for exercise load calculation (training impulse, TRIMP)...
September 4, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28858608/correction-in-vivo-targeting-of-de-novo-dna-methylation-by-histone-modifications-in-yeast-and-mouse
#13
Marco Morselli, William A Pastor, Barbara Montanini, Kevin Nee, Roberto Ferrari, Kai Fu, Giancarlo Bonora, Liudmilla Rubbi, Amander T Clark, Simone Ottonello, Steven E Jacobsen, Matteo Pellegrini
No abstract text is available yet for this article.
August 31, 2017: ELife
https://www.readbyqxmd.com/read/28857246/sleep-deprivation-induces-pathological-changes-in-rat-masticatory-muscles-role-of-toll-like-signaling-pathway-and-atrophy
#14
Veronica Quispe Yujra, Hanna Karen Moreira Antunes, Marcos Mônico-Neto, Luciana Pellegrini Pisani, Aline Boveto Santamarina, Hannaniah Tardivo Quintana, Flavia de Oliveira, Celina Tizuko Fujiyama Oshima, Daniel Araki Ribeiro
The aim of this study was to evaluate the toll like signaling pathway and atrophy after sleep deprivation (SD) in rat masticatory muscles: masseter and temporal. A total of twenty-four animals was distributed into three groups: Control group (CTL, n = 8), subjected to SD for 96 hours (SD96, n = 8) and subjected to SD for 96 hours more 96 hours of sleep recovery (SD96 + R, n = 8). Histopathological analysis revealed the presence of acute inflammatory cells, congested vessels, fibrosis and high cellularity in the skeletal muscle fibers from masseter and temporal submitted to SD...
August 31, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28853626/profile-of-the-illegal-import-of-products-of-animal-origin-to-brazilian-cities-at-the-border-with-argentina-and-uruguay
#15
J G Pereira, V M Soares, E A R Santos, L E Tadielo, D C P Pellegrini, E H Duval, W P Silva
International food transit is a risk to public and animal health when not subject to legal importation sanitation procedures. Due to the extensive border area, illegal food import in Brazil is a common practice, especially in Rio Grande do Sul (RS), a state that borders with Argentina and Uruguay. The objective of this study was to evaluate the profile of Brazilians living in cities in RS that border with Argentina (BR-AR) or Uruguay (BR-UR) regarding the practice of illegal import of products of animal origin and to determine associations between the population characteristics and illegal import...
August 30, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28851931/dietary-glycemic-index-glycemic-load-and-cancer-risk-results-from-the-epic-italy-study
#16
S Sieri, C Agnoli, V Pala, S Grioni, F Brighenti, N Pellegrini, G Masala, D Palli, A Mattiello, S Panico, F Ricceri, F Fasanelli, G Frasca, R Tumino, V Krogh
Factors linked to glucose metabolism are involved in the etiology of several cancers. High glycemic index (GI) or high glycemic load (GL) diets, which chronically raise postprandial blood glucose, may increase cancer risk by affecting insulin-like growth factor. We prospectively investigated cancer risk and dietary GI/GL in the EPIC-Italy cohort. After a median 14.9 years, 5112 incident cancers and 2460 deaths were identified among 45,148 recruited adults. High GI was associated with increased risk of colon and bladder cancer...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845626/obesity-in-survivors-of-childhood-cancer-a-review
#17
Julia Ferrari Carneiro Teixeira, Priscila Dos Santos Maia-Lemos, Mônica Dos Santos Cypriano, Luciana Pellegrini Pisani
Obesity is a late effect of antineoplastic treatment in childhood cancer survivors and this correlates with chronic complications. This review examines the data currently available to health professionals, for increasing awareness and identifying strategies to address the treatment and prevention of late effects. The mechanism involved in the pathophysiology of obesity remains unclear. However, damage to the hypothalamus and endocrine disorders (e.g. insulin and leptin resistance) and a positive energetic balance may play a role in increasing obesity rates...
September 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28844373/blood-derived-eye-drops-for-the-treatment-of-cornea-and-ocular-surface-diseases
#18
REVIEW
Giuseppe Giannaccare, Piera Versura, Marina Buzzi, Laura Primavera, Marco Pellegrini, Emilio C Campos
The use of blood derived eye drops for the treatment of ocular surface disorders has become increasingly popular in recent years. The mechanism of action is the stimulation of cellular proliferation and migration by supplying an active mixture of growth factors and cytokines at the ocular surface, thus mimicking the function of the lacking natural tears. Blood derived eye drops have been used in the last decades for the treatment of a variety of ocular surface diseases, including mainly dry eye disease, persistent corneal epithelial defect, corneal ulcer, ocular surface burn, recurrent corneal erosion and limbal stem-cell deficiency...
August 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28840322/functional-significance-of-extent-and-timing-of-muscle-activation-during-double-poling-on-snow-with-increasing-speed
#19
Chiara Zoppirolli, Gennaro Boccia, Lorenzo Bortolan, Federico Schena, Barbara Pellegrini
PURPOSE: To evaluate the level of activation and timing of upper- and lower-body muscles during double poling at different speeds on snow. METHODS: Nineteen well-trained cross-country skiers volunteered to double pole on a flat snowy track at different speeds (15, 18, 21 km h(-1)). The target speeds could be maintained by the skiers thanks to the use of an audio-pace system in combination with cones spaced equally alongside the track. Only 11 subjects were finally included in the analysis, since their actual speeds, calculated through a photocell system, were within ±0...
August 24, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28829805/expression-of-il-23-th17-related-cytokines-in-basal-cell-carcinoma-and-in-the-response-to-medical-treatments
#20
Cristina Pellegrini, Augusto Orlandi, Gaetana Costanza, Alessandro Di Stefani, Antonella Piccioni, Antonella Di Cesare, Andrea Chiricozzi, Amedeo Ferlosio, Ketty Peris, Maria Concetta Fargnoli
Several immune-related markers have been implicated in basal cell carcinoma (BCC) pathogenesis. The BCC inflammatory infiltrate is dominated by Th2 cytokines, suggesting a specific state of immunosuppression. In contrast, regressing BCC are characterized by a Th1 immune response with IFN-γ promoting a tumor suppressive activity. IL-23/Th17-related cytokines, as interleukin (IL)-17, IL-23 and IL-22, play a significant role in cutaneous inflammatory diseases, but their involvement in skin carcinogenesis is controversial and is poorly investigated in BCC...
2017: PloS One
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