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https://www.readbyqxmd.com/read/29347283/stochastic-wave-function-unravelling-of-the-generalized-lindblad-equation
#1
V Semin, I Semina, F Petruccione
We investigate generalized non-Markovian stochastic Schrödinger equations (SSEs), driven by a multidimensional counting process and multidimensional Brownian motion introduced by A. Barchielli and C. Pellegrini [J. Math. Phys. 51, 112104 (2010)JMAPAQ0022-248810.1063/1.3514539]. We show that these SSEs can be translated in a nonlinear form, which can be efficiently simulated. The simulation is illustrated by the model of a two-level system in a structured bath, and the results of the simulations are compared with the exact solution of the generalized master equation...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29345371/therapeutic-manipulation-of-host-cell-death-pathways-to-facilitate-clearance-of-persistent-viral-infections
#2
REVIEW
James Cooney, Cody Allison, Simon Preston, Marc Pellegrini
Most persistent viral infections can be controlled, but not cured, by current therapies. Abrogated antiviral immunity and stable latently infected cells represent major barriers to cure. This necessitates life-long suppressive antiviral therapy. Achieving a cure for HIV, hepatitis B virus, Epstein Barr-virus, and others, requires novel approaches to facilitate the clearance of infected cells from the host. One such approach is to target host cell death pathways, rather than the virus itself. Here, we summarize recent findings from studies that have utilized therapeutics to manipulate host cell death pathways as a means to treat and cure persistent viral infections...
January 9, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29345343/mycobacterium-tuberculosis-rewiring-host-cell-signaling-to-promote-infection
#3
REVIEW
Michael D Stutz, Michelle P Clark, Marcel Doerflinger, Marc Pellegrini
The ability of Mycobacterium tuberculosis to cause disease hinges upon successfully thwarting the innate defenses of the macrophage host cell. The pathogen's trump card is its armory of virulence factors that throw normal host cell signaling into disarray. This process of subverting the macrophage begins upon entry into the cell, when M. tuberculosis actively inhibits the fusion of the bacilli-laden phagosomes with lysosomes. The pathogen then modulates an array of host signal transduction pathways, which dampens the macrophage's host-protective cytokine response, while simultaneously adapting host cell metabolism to stimulate lipid body accumulation...
December 15, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29344076/response-to-dr-pellegrini-regarding-comments-on-bilateral-non-arteritic-anterior-ischaemic-optic-neuropathy-as-the-presentation-of-systemic-amyloidosis
#4
M Z Kanaan, R Pandit, Margaret Dayan
No abstract text is available yet for this article.
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344075/reply-to-bilateral-non-arteritic-anterior-ischaemic-optic-neuropathy-as-the-presentation-of-systemic-amyloidosis
#5
Francesco Pellegrini, Daniele Cirone, Luca De Simone, Luca Cimino, Cristina Ciabattoni
No abstract text is available yet for this article.
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344059/retinitis-pigmentosa-sine-pigmento-mimicking-a-chiasm-disease
#6
Francesco Pellegrini, Giovanni Prosdocimo, Francesco Romano, Emanuela Interlandi
A 75-year-old woman presented to her ophthalmologist complaining of visual loss for several years. The ophthalmic examination was remarkable for a bitemporal visual field defect. Magnetic resonance imaging (MRI) scan of the brain was normal without evidence of chiasm compression. Neuro-ophthalmic examination was consistent with a retinal rather than a chiasmal disease. Retinal multimodal imaging helped in the correct diagnosis of retinitis pigmentosa, later confirmed by genetic testing.
August 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29340148/reducing-unnecessary-culturing-a-systems-approach-to-evaluating-urine-culture-ordering-and-collection-practices-among-nurses-in-two-acute-care-settings
#7
Robert Redwood, Mary Jo Knobloch, Daniela C Pellegrini, Matthew J Ziegler, Michael Pulia, Nasia Safdar
Background: Inappropriate ordering and acquisition of urine cultures leads to unnecessary treatment of asymptomatic bacteriuria (ASB). Treatment of ASB contributes to antimicrobial resistance particularly among hospital-acquired organisms. Our objective was to investigate urine culture ordering and collection practices among nurses to identify key system-level and human factor barriers and facilitators that affect optimal ordering and collection practices. Methods: We conducted two focus groups, one with ED nurses and the other with ICU nurses...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29339173/neuroprotective-effects-of-topiramate-and-memantine-in-combination-with-hypothermia-in-hypoxic-ischemic-brain-injury-in-vitro-and-in-vivo
#8
Elisa Landucci, Luca Filippi, Elisabetta Gerace, Serena Catarzi, Renzo Guerrini, Domenico E Pellegrini-Giampietro
Hypoxic-ischemic encephalopathy (HIE) is a major cause of perinatal mortality and subsequent severe neurological sequelae. Mild hypothermia is a standard therapy for HIE, but is used only in selected Reference Centers and in neonates >1800 g. Since neuronal death following HIE occurs by a cascade of events triggered by activation of glutamate receptors, we used in vitro and in vivo models of HIE to examine whether the AMPA/kainate receptor antagonist topiramate and the NMDA receptor antagonist memantine could exert neuroprotective effects, alone or in combination with hypothermia...
January 12, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29335894/management-of-periprosthetic-shoulder-infections-with-the-use-of-a-permanent-articulating-antibiotic-spacer
#9
Antonio Pellegrini, Claudio Legnani, Vittorio Macchi, Enzo Meani
INTRODUCTION: Management of periprosthetic shoulder infections (PSIs) still remains challenging. We conducted a retrospective case study to assess the outcomes of definitive articulating antibiotic spacer implantation in a cohort of elderly, low-demanding patients. We hypothesized that in patients with low functional demands seeking pain relief with chronic PSIs, treatment with a definitive articulating antibiotic spacer would lead to satisfying results concerning eradication of the infection, improvement of pain, and improving shoulder function...
January 15, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29329109/cluster-analysis-and-subgrouping-to-investigate-inter-individual-variability-to-non-invasive-brain-stimulation-a-systematic-review
#10
Michael Pellegrini, Maryam Zoghi, Shapour Jaberzadeh
Cluster analysis and other subgrouping techniques have risen in popularity in recent years in non-invasive brain stimulation research in the attempt to investigate the issue of inter-individual variability - the issue of why some individuals respond, as traditionally expected, to non-invasive brain stimulation protocols and others do not. Cluster analysis and subgrouping techniques have been used to categorise individuals, based on their response patterns, as responder or non-responders. There is, however, a lack of consensus and consistency on the most appropriate technique to use...
January 12, 2018: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29325663/daily-and-seasonal-influences-on-dietary-self-monitoring-using-a-smartphone-application
#11
Christine A Pellegrini, David E Conroy, Siobhan M Phillips, Angela Fidler Pfammatter, H Gene McFadden, Bonnie Spring
OBJECTIVE: To examine within-person variation in dietary self-monitoring during a 6-month technology-supported weight loss trial as a function of time-varying factors including time in the study, day of the week, and month of the year. METHODS: Smartphone self-monitoring data were examined from 31 obese adults (aged 18-60 years) who participated in a 6-month technology-supported weight loss program. Multilevel regression modeling was used to examine within-person variation in dietary self-monitoring...
January 2018: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29306589/oxidative-stress-dependent-mmp-13-activity-underlies-glucose-neurotoxicity
#12
Ashley L Waldron, Patricia A Schroder, Kelly L Bourgon, Jessie K Bolduc, James L Miller, Adriana D Pellegrini, Amanda L Dubois, Magdalena Blaszkiewicz, Kristy L Townsend, Sandra Rieger
BACKGROUND: A complication of diabetes is neuropathy, a condition of sensory axon degeneration that originates in the epidermis. The mechanisms remain unknown but reactive oxygen species (ROS) have been implicated in this condition. In this study, we assessed the role of ROS and a candidate downstream target, MMP-13 in glucose-induced sensory axon degeneration in zebrafish and mice. METHODS: The effects of glucose on metabolism and sensory axon degeneration were assessed using qPCR and live imaging...
December 6, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29306485/comparison-of-carbohydrate-antigen-125-and-n-terminal-pro-brain-natriuretic-peptide-for-risk-prediction-after-transcatheter-aortic-valve-implantation
#13
Tobias Rheude, Costanza Pellegrini, Hans Schmid, Teresa Trenkwalder, N Patrick Mayr, Michael Joner, Albert M Kasel, Stefan Holdenrieder, Julio Nunez, Juan Sanchis, Vicent Bodi, Heribert Schunkert, Adnan Kastrati, Christian Hengstenberg, Oliver Husser
Elevated carbohydrate antigen 125 (CA125) and N-terminal pro-brain natriuretic peptide (NTproBNP) have been associated with adverse outcome after transcatheter aortic valve implantation (TAVI). This study performs a comparison of both biomarkers for prognosis after TAVI. The study includes 363 patients. The primary end point was all-cause death or readmission for worsening congestive heart failure within 1 year after TAVI, and this end point occurred in 16% of the population. The optimal cutoff to predict the primary end point was 18...
November 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29300267/ocular-surface-workup-with-automated-noninvasive-measurements-for-the-diagnosis-of-meibomian-gland-dysfunction
#14
Giuseppe Giannaccare, Luca Vigo, Marco Pellegrini, Stefano Sebastiani, Francesco Carones
PURPOSE: To analyze diagnostic performance of an ocular surface workup based on automated noninvasive measurements in the diagnosis of meibomian gland dysfunction (MGD). METHODS: Two hundred ninety-eight eyes of 149 patients with MGD and 54 eyes of 27 control patients were analyzed. Ocular Surface Disease Index (OSDI), noninvasive breakup time (BUT), lipid layer thickness, meibomian gland loss, and tear osmolarity were calculated. The correlations among variables in the MGD group were analyzed...
January 3, 2018: Cornea
https://www.readbyqxmd.com/read/29298409/dual-roles-of-ctf18-rfc-loading-the-clamp-and-angling-for-the-polymerase
#15
Luca Pellegrini
Clamp loaders such as Ctf18-RFC assist DNA replication by loading the PCNA clamp onto DNA. In this issue of Structure, Grabarczyk et al. (2018) reveal that a hook-like structure formed by the unique Dcc1 and Ctf8 subunits mediates the interaction of Ctf18-RFC with the leading strand DNA polymerase ɛ.
January 2, 2018: Structure
https://www.readbyqxmd.com/read/29297708/determinants-of-elevated-carbohydrate-antigen-125-in-patients-with-severe-symptomatic-aortic-valve-stenosis-referred-for-transcatheter-aortic-valve-implantation
#16
Tobias Rheude, Costanza Pellegrini, Wibke Reinhard, Teresa Trenkwalder, Wolfgang Koenig, N Patrick Mayr, Michael Joner, Julio Núñez, Stefan Holdenrieder, Heribert Schunkert, Adnan Kastrati, Christian Hengstenberg, Oliver Husser
PURPOSE: Elevated carbohydrate antigen 125 (CA125) predicts adverse outcome after transcatheter aortic valve implantation (TAVI). While known underlying pathophysiological mechanisms of elevated CA125 include serosal effusions and inflammatory stimuli, clinical determinants associated with elevated CA125 in patients referred for TAVI remain unknown. Therefore, we investigated clinical, laboratory and echocardiographic determinants of elevated CA125 in patients with severe aortic valve stenosis referred for TAVI...
January 3, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29285670/a-3-variable-prognostic-score-3-ps-for-overall-survival-prediction-in-metastatic-castration-resistant-prostate-cancer-treated-with-223radium-dichloride
#17
Viviana Frantellizzi, Alessio Farcomeni, Giulia Anna Follacchio, Massimiliano Pacilio, Rosanna Pellegrini, Roberto Pani, Giuseppe De Vincentis
OBJECTIVE: In mCRPC patients treated with 223Ra, a major issue is the validation of reliable prognostic and predictive biomarkers to maximize clinical benefit and minimize toxicities and costs. Bearing in mind how changes in tALP did not meet statistical requirements as surrogate marker for survival, aim of this single-center retrospective study was to characterize the prognostic and predictive role of baseline clinical variables associated with overall survival in patients receiving 223Ra treatment...
December 28, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29280318/navigating-market-authorization-the-path-holoclar-took-to-become-the-first-stem-cell-product-approved-in-the-european-union
#18
Graziella Pellegrini, Diego Ardigò, Giovanni Milazzo, Giorgio Iotti, Paolo Guatelli, Danilo Pelosi, Michele De Luca
Gene therapy, cell therapy, and tissue engineering have the potential to revolutionize the treatment of disease and injury. Attaining marketing authorization for such advanced therapy medicinal products (ATMPs) requires a rigorous scientific evaluation by the European Medicines Agency-authorization is only granted if the product can fulfil stringent requirements for quality, safety, and efficacy. However, many ATMPs are being provided to patients under alternative means, such as "hospital exemption" schemes...
January 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29261524/core-set-of-patient-reported-outcomes-in-pancreatic-cancer-coprac-an-international-delphi-study-among-patients-and-health-care-providers
#19
Lennart B van Rijssen, Arja Gerritsen, Inge Henselmans, Mirjam A Sprangers, Marc Jacobs, Claudio Bassi, Olivier R Busch, Carlos Fernández-Del Castillo, Zhi Ven Fong, Jin He, Jin-Young Jang, Ammar A Javed, Sun-Whe Kim, Laura Maggino, Abhishek Mitra, Vikas Ostwal, Silvia Pellegrini, Shailesh V Shrikhande, Johanna W Wilmink, Christopher L Wolfgang, Hanneke W van Laarhoven, Marc G Besselink
OBJECTIVE: To establish an international core set of patient-reported outcomes (PROs) selected by both patients and healthcare providers (HCPs) from the United States (US), Europe, and Asia. SUMMARY BACKGROUND DATA: PROs are increasingly recognized in pancreatic cancer studies. There is no consensus on which of the many available PROs are most important. METHODS: A multicenter Delphi study among patients with pancreatic cancer (curative- and palliative-setting) and HCPs in 6 pancreatic centers in the US (Baltimore, Boston), Europe (Amsterdam, Verona), and Asia (Mumbai, Seoul) was performed...
December 19, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29259560/the-energetics-during-the-world-s-most-challenging-mountain-ultra-marathon-a-case-study-at-the-tor-des-geants%C3%A2
#20
Aldo Savoldelli, Alessandro Fornasiero, Pietro Trabucchi, Eloisa Limonta, Antonio La Torre, Francis Degache, Barbara Pellegrini, Grégoire P Millet, Gianluca Vernillo, Federico Schena
Purpose: To provide insights into the energy requirements as well as the physiological adaptations of an experienced 50-year-old ultra-marathon male athlete during the world's most challenging mountain ultra-marathon (MUM). Methods: The international race supporting the study was the Tor des Geants®, characterized by 330 km with +24,000 m D+ to be covered within 150 h. Before the MUM, we assessed the peak oxygen uptake ([Formula: see text]) by means of an incremental graded running test. During the MUM we monitored six ascents (once per race day) with a portable gas analyzer, a GPS and a finger pulse oximeter...
2017: Frontiers in Physiology
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