keyword
MENU ▼
Read by QxMD icon Read
search

Pellegrini

keyword
https://www.readbyqxmd.com/read/28735754/correlation-between-pulmonary-artery-pressure-and-thoracic-impedance-insights-from-daily-monitoring-through-an-implanted-device-in-chronic-heart-failure
#1
Giovanni Battista Perego, Matteo Oldani, Dario Pellegrini, Francesco Maria Angelo Brasca, Gabriella Malfatto, Alessandra Villani, Roberto Brambilla, Valeria Rella, Gianfranco Parati
BACKGROUND: Thoracic impedance (TI) decrease and pulmonary artery pressure (PAP) elevation precede acute decompensation in congestive heart failure (HF). However, the relationship between TI and PAP has been studied only in the context of acute decompensation. METHODS: This prospective, observational study enrolled subjects with reduced ejection fraction HF, previously implanted with an ICD capable of measuring TI. Patients underwent implantation of a sensor for direct measurement of PAP (CardioMEMs™)...
July 17, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28733610/environmental-impact-of-omnivorous-ovo-lacto-vegetarian-and-vegan-diet
#2
Alice Rosi, Pedro Mena, Nicoletta Pellegrini, Silvia Turroni, Erasmo Neviani, Ilario Ferrocino, Raffaella Di Cagno, Luca Ruini, Roberto Ciati, Donato Angelino, Jane Maddock, Marco Gobbetti, Furio Brighenti, Daniele Del Rio, Francesca Scazzina
Food and beverage consumption has a great impact on the environment, although there is a lack of information concerning the whole diet. The environmental impact of 153 Italian adults (51 omnivores, 51 ovo-lacto-vegetarians, 51 vegans) and the inter-individual variability within dietary groups were assessed in a real-life context. Food intake was monitored with a 7-d dietary record to calculate nutritional values and environmental impacts (carbon, water, and ecological footprints). The Italian Mediterranean Index was used to evaluate the nutritional quality of each diet...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729486/comment-on-the-4fe4s-cluster-of-human-dna-primase-functions-as-a-redox-switch-using-dna-charge-transport
#3
Luca Pellegrini
O'Brien et al (Research Article, 24 February 2017, eaag1789) report that the iron-sulfur cluster of primase has a redox role in enzyme activity. Their analysis is based on a partially misfolded structure of the iron-sulfur cluster domain of primase. In the correctly folded structure, two of the three tyrosines putatively involved in electron transfer, Y345 and Y347, contact the RNA/DNA helix, providing an alternative explanation for the data of O'Brien et al.
July 21, 2017: Science
https://www.readbyqxmd.com/read/28729485/response-to-comments-on-the-4fe4s-cluster-of-human-dna-primase-functions-as-a-redox-switch-using-dna-charge-transport
#4
Elizabeth O'Brien, Marilyn E Holt, Matthew K Thompson, Lauren E Salay, Aaron C Ehlinger, Walter J Chazin, Jacqueline K Barton
Baranovskiy et al and Pellegrini argue that, based on structural data, the path for charge transfer through the [4Fe4S] domain of primase is not feasible. Our manuscript presents electrochemical data directly showing charge transport through DNA to the [4Fe4S] cluster of a primase p58C construct and a reversible switch in the DNA-bound signal with oxidation/reduction, which is inhibited by mutation of three tyrosine residues. Although the dispositions of tyrosines differ in different constructs, all are within range for microsecond electron transfer...
July 21, 2017: Science
https://www.readbyqxmd.com/read/28726155/initial-weight-loss-response-as-an-indicator-for-providing-early-rescue-efforts-to-improve-long-term-treatment-outcomes
#5
REVIEW
Jessica L Unick, Christine A Pellegrini, Kathryn E Demos, Leah Dorfman
PURPOSE OF REVIEW: There is a large variability in response to behavioral weight loss (WL) programs. Reducing rates of obesity and diabetes may require more individuals to achieve clinically significant WL post-treatment. Given that WL within the first 1-2 months of a WL program is associated with long-term WL, it may be possible to improve treatment outcomes by identifying and providing additional intervention to those with poor initial success (i.e., "early non-responders"). We review the current literature regarding early non-response to WL programs and discuss how adaptive interventions can be leveraged as a strategy to "rescue" early non-responders...
September 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28726153/immunological-issues-after-stem-cell-based-%C3%AE-cell-replacement
#6
REVIEW
Valeria Sordi, Silvia Pellegrini, Lorenzo Piemonti
PURPOSE OF REVIEW: Islet and pancreas transplantation prove that β cell replacement can cure the glycemic derangements in type 1 diabetes (T1D). Induced pluripotent stem cells (iPSCs) can differentiate into functional insulin-producing cells, able to restore normoglycemia in diabetic animal models. iPSCs in particular can be derived from the somatic cells of a person with T1D. This review aims to clarify if it is possible to transplant autologous iPSC-derived β cells without immunosuppression or which are the alternative approaches...
September 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28724142/the-aging-physician-and-the-medical-profession-a-review
#7
E Patchen Dellinger, Carlos A Pellegrini, Thomas H Gallagher
Importance: The issue of the aging physician and when to cease practice has been controversial for many years. There are reports of prominent physicians who practiced after becoming dangerous in old age, but the profession has not demonstrated the ability to prevent this. A mandatory retirement age could be discriminatory and take many competent physicians out of practice and risk a physician shortage. An increasing body of evidence regarding the relationship between physicians' age and performance has led organizations, such as the American College of Surgeons, to revisit this challenge...
July 19, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28720283/addressing-the-digital-divide-in-contemporary-biology-lessons-from-teaching-unix
#8
Serghei Mangul, Lana S Martin, Alexander Hoffmann, Matteo Pellegrini, Eleazar Eskin
Life and medical science researchers increasingly rely on applications that lack a graphical interface. Scientists who are not trained in computer science face an enormous challenge analyzing high-throughput data. We present a training model for use of command-line tools when the learner has little to no prior knowledge of UNIX.
July 15, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28719779/cement-casting-to-optimize-reconstruction-of-chronic-osteochondral-lesions-of-the-talus
#9
Jorge Pulgar, Mario Escudero, Giovanni Carcuro, Adam Schiff, Manuel Pellegrini
Few surgical techniques have been described for reconstruction in massive osteochondral lesions of the talus, and there is limited evidence of techniques for accurately reproducing native talar anatomy with bone auto/allograft techniques. In this article, we present a novel technique, which is highly reproducible, using bone cement to restore the congruence and anatomy of the ankle joint. LEVELS OF EVIDENCE: Level V: Technical tip.
August 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28716814/potency-matched-dual-cytokine-antibody-fusion-proteins-for-cancer-therapy
#10
Roberto De Luca, Alex Soltermann, Francesca Pretto, Catherine Pemberton-Ross, Giovanni Pellegrini, Sarah Wulhfard, Dario Neri
A novel biopharmaceutical, consisting of the F8 monoclonal antibody (specific to a splice isoform of fibronectin) simultaneously fused to both tumor necrosis factor and interleukin-2, was found to react with the majority of solid tumors and hematological malignancies in mouse and man, but not with healthy adult tissues. The product selectively localized to neoplastic lesions in vivo, as evidenced by quantitative biodistribution studies using radioiodinated protein preparations. When the potency of the cytokine payloads was matched by a single-point mutation, the resulting fusion protein (IL2-F8-TNF(mut)) eradicated soft-tissue sarcomas in immunocompetent mice, which did not respond to individual antibody-cytokine fusion proteins or by standard doxorubicin treatment...
July 17, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28715593/physical-exercise-improves-total-antioxidant-capacity-and-gene-expression-in-rat-hippocampal-tissue
#11
F Franzoni, G Federighi, J Fusi, E Cerri, R Banducci, A Petrocchi, A Innocenti, C Pruneti, S Daniele, S Pellegrini, C Martini, R Scuri, F Galetta
Exercise may exert beneficial effects on cognitive functions and play an important role in the prevention of neurodegenerative diseases. Such effects seem to be mediated by changes in anti-oxidative status, but limited information is available on the nature of molecular pathways supporting the antioxidant effects of exercise in the brain. In this study 3-5-month-old male Wistar albino rats were subjected to three times/week moderate intensity exercise on a rodent treadmill for a period of 6 weeks. The tissue antioxidant activity towards various reactive oxygen species (ROS) was determined in the hippocampus...
July 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/28713058/regression-of-unusual-optic-disk-neovascularization-after-adalimumab-in-a-case-of-juvenile-idiopathic-arthritis-related-uveitis
#12
Emanuela Interlandi, Loredana Latanza, Francesco Pellegrini, Carlos Pavesio
No abstract text is available yet for this article.
July 13, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28700221/transuranic-hybrid-materials-crystallographic-and-computational-metrics-of-supramolecular-assembly
#13
Robert G Surbella, Lucas Colucci Ducati, Kristi L Pellegrini, Bruce K McNamara, Jochen Autschbach, Jon Michael Schwantes, Christopher L Cahill
A family of twelve supramolecular [AnO2Cl4](2-) (An = U, Np, Pu) containing compounds assembled via hydrogen and halogen bonds donated by substituted 4-X-pyridinium cations, X = H, Cl, Br, I is reported. These materials were prepared from a robust room-temperature synthesis wherein crystallization of unhydrolyzed and valence pure [An(VI)O2Cl4](2-) (An = U, Np, Pu) tectons are the norm. We present a hierarchy of assembly criteria based on crystallographic observations, and subsequently quantify the strengths of the non-covalent interactions using Kohn-Sham density functional calculations...
July 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28699925/quantifying-baseline-fixed-charge-density-in-healthy-human-cartilage-endplate-a-two-point-electrical-conductivity-method
#14
Yongren Wu, Sarah E Cisewski, Yi Sun, Brooke J Damon, Barton L Sachs, Vincent D Pellegrini, Elizabeth H Slate, Hai Yao
STUDY DESIGN: Regional measurements of fixed charge densities (FCDs) of healthy human cartilage endplate (CEP) using a two-point electrical conductivity approach. OBJECTIVE: To determine the FCDs at four different regions (central, lateral, anterior, and posterior) of human CEP, and correlate the FCDs with tissue biochemical composition. SUMMARY OF BACKGROUND DATA: The CEP, a thin layer of hyaline cartilage on the cranial and caudal surfaces of the intervertebral disc, plays an irreplaceable role in maintaining the unique physiological mechano-electrochemical environment inside the disc...
January 5, 2017: Spine
https://www.readbyqxmd.com/read/28699480/adulteration-practices-of-psychoactive-illicit-drugs-an-updated-review
#15
Renata Solimini, Maria Concetta Rotolo, Manuela Pellegrini, Adele Minutillo, Roberta Pacifici, Francesco Paolo Busardò, Simona Zaami
BACKGROUND: It is well known that powdery drugs such as cocaine and heroin are frequently adulterated or diluted predominantly to obtain more doses and to increase the drug dealer's profits, but also to enhance, to modify or to oppose drug effects. METHODS: The aim of this report is to provide an overview of the recent scientific literature on medicines as well as on new psychoactive substances, used as cutting agents (i.e. pharmacologically active adulterants) and on the related adverse health effects on consumers, possibly due to the synergistic effect of the adulterants laced with substances of abuse, which represent a matter of great concern because of the frequent fatalities...
July 10, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28699011/reflectance-spectroscopy-a-novel-approach-to-better-understand-and-monitor-the-impact-of-air-pollution-on-mediterranean-plants
#16
Lorenzo Cotrozzi, Philip A Townsend, Elisa Pellegrini, Cristina Nali, John J Couture
The Mediterranean basin can be considered a hot spot not only in terms of climate change (CC) but also for air quality. Assessing the impact of CC and air pollution on ecosystem functions is a challenging task, and adequate monitoring techniques are needed. This paper summarizes the present knowledge on the use of reflectance spectroscopy for the evaluation of the effects of air pollution on plants. First, the history of this technique is outlined. Next, we describe the vegetation reflectance spectrum, how it can be scaled from leaf to landscape levels, what information it contains, and how it can be exploited to understand plant and ecosystem functions...
July 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28695362/metabolic-and-kinematic-parameters-during-walking-with-poles-in-parkinson-s-disease
#17
Francesca Nardello, F Bombieri, M Tinazzi, F Schena, B Pellegrini
In healthy people, energy expenditure is generally higher during walking with poles (WP) than during conventional walking (W). In persons with Parkinson's disease (PD), walking is slower and may be associated with greater energy consumption, stride-to-stride variability, and difficulty in regulating stride length. The aim of this study was to determine whether treadmill WP at three different speeds could induce changes in gait kinematics and oxygen consumption in PD patients. The study sample was 20 patients with mild-to-moderate PD and 20 age-matched healthy controls...
July 10, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28693373/prenatal-growth-patterns-and-birthweight-are-associated-with-differential-dna-methylation-and-gene-expression-of-cardiometabolic-risk-genes-in-human-placentas-a-discovery-based-approach
#18
Pao-Yang Chen, Alison Chu, Wen-Wei Liao, Liudmilla Rubbi, Carla Janzen, Fei-Man Hsu, Shanthie Thamotharan, Amit Ganguly, Larry Lam, Dennis Montoya, Matteo Pellegrini, Sherin U Devaskar
Inherent genetic programming and environmental factors affect fetal growth in utero. Epidemiologic data in growth-altered fetuses, either intrauterine growth restricted (IUGR) or large for gestational age (LGA), demonstrate that these newborns are at increased risk of cardiometabolic disease in adulthood. There is growing evidence that the in utero environment leads to epigenetic modification, contributing to eventual risk of developing heart disease or diabetes. In this study, we used reduced representation bisulfite sequencing to examine genome-wide DNA methylation variation in placental samples from offspring born IUGR, LGA, and appropriate for gestational age (AGA) and to identify differential methylation of genes important for conferring risk of cardiometabolic disease...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28678133/the-fourth-year-of-medical-school-time-for-reassessment-aoa-critical-issues
#19
Benjamin A Alman, James J Purtill, Vincent D Pellegrini, Peter Scoles
Most U.S. medical schools follow the 4-year model, consisting of 2 preclinical years, core clinical experience, and a fourth year intended to permit students to increase clinical competency, to explore specialty areas, and to transition to residency. Although the design and delivery of Years 1 through 3 have evolved to meet new challenges and expectations, the structure of Year 4 remains largely unchanged. For most students considering a career in orthopaedics, Year 4 is a series of elective rotations in which educational objectives become secondary to interviewing for residency programs...
July 5, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28674543/losing-the-warning-signal-drought-compromises-the-cross-talk-of-signaling-molecules-in-quercus-ilex-exposed-to-ozone
#20
Lorenzo Cotrozzi, Elisa Pellegrini, Lucia Guidi, Marco Landi, Giacomo Lorenzini, Rossano Massai, Damiano Remorini, Mariagrazia Tonelli, Alice Trivellini, Paolo Vernieri, Cristina Nali
Understanding the interactions between drought and acute ozone (O3) stress in terms of signaling molecules and cell death would improve the predictions of plant responses to climate change. The aim was to investigate whether drought stress influences the responses of plants to acute episodes of O3 exposure. In this study, the behavior of 84 Mediterranean evergreen Quercus ilex plants was evaluated in terms of cross-talk responses among signaling molecules. Half of the sample was subjected to drought (20% of the effective daily evapotranspiration, for 15 days) and was later exposed to an acute O3 exposure (200 nL L(-1) for 5 h)...
2017: Frontiers in Plant Science
keyword
keyword
60310
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"