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https://www.readbyqxmd.com/read/28098168/the-il-17a-rs2275913-single-nucleotide-polymorphism-is-associated-with-protection-to-tuberculosis-but-related-to-higher-disease-severity-in-argentina
#1
A Rolandelli, R E Hernández Del Pino, J M Pellegrini, N L Tateosian, N O Amiano, S de la Barrera, N Casco, M Gutiérrez, D J Palmero, V E García
Mycobacterium tuberculosis (Mtb) causes nearly 10 millions of new tuberculosis disease cases annually. However, most individuals exposed to Mtb do not develop tuberculosis, suggesting the influence of a human genetic component. Here, we investigated the association of the rs2275913 SNP (G → A) from IL-17A and tuberculosis in Argentina by a case-control study. Furthermore, we evaluated in vitro the functional relevance of this SNP during the immune response of the host against Mtb and analyzed its impact on clinical parameters of the disease...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28090316/the-role-of-tumour-necrosis-factor-in-hepatitis-b-infection-jekyll-and-hyde
#2
REVIEW
Zina Valaydon, Marc Pellegrini, Alexander Thompson, Paul Desmond, Peter Revill, Gregor Ebert
Chronic hepatitis B (CHB) is a major health problem worldwide and is associated with significant long-term morbidity and mortality. The hepatitis B virus (HBV) is a hepatotropic virus that is capable of integrating in the host nucleus permanently resulting in lifelong infection. To date, there is no definitive cure for HBV, as our current treatments cannot eradicate the viral reservoir that has integrated in the liver. Elucidating the immunopathogenesis is key to finding a therapeutic target for HBV as the virus is not in itself cytopathic but the immune response to the virus causes the majority of the cellular injury...
December 2016: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28077860/impact-of-cuff-positioning-on-blood-pressure-measurement-accuracy-may-a-specially-designed-cuff-make-a-difference
#3
Grzegorz Bilo, Oscar Sala, Carlotta Perego, Andrea Faini, Lan Gao, Anna Głuszewska, Juan Eugenio Ochoa, Dario Pellegrini, Laura Maria Lonati, Gianfranco Parati
During blood pressure (BP) measurement, the recommended positioning of the cuff bladder center is directly above the brachial artery. We investigated the relevance of incorrect cuff positioning during (1) auscultatory measurement with an appropriate or improperly small cuff and (2) oscillometric measurement with a wide-range cuff designed to guarantee accurate measurements regardless of position. In subjects with wide BP and arm circumference ranges, (1) auscultatory BP was repeatedly measured with a properly positioned cuff (reference) and, simultaneously, with an identical cuff placed on the other arm in either a correct or an incorrect position (test)...
January 12, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28075118/uranyl-peroxide-cage-cluster-solubility-in-water-and-the-role-of-the-electrical-double-layer
#4
Kathryn M Peruski, Varinia Bernales, Mateusz Dembowski, Haylie L Lobeck, Kristi L Pellegrini, Ginger E Sigmon, Sarah Hickam, Christine M Wallace, Jennifer E S Szymanowski, Enrica Balboni, Laura Gagliardi, Peter C Burns
Uranium concentrations as high as 2.94 × 10(5) parts per million (1.82 mol of U/1 kg of H2O) occur in water containing nanoscale uranyl cage clusters. The anionic cage clusters, with diameters of 1.5-2.5 nm, are charge-balanced by encapsulated cations, as well as cations within their electrical double layer in solution. The concentration of uranium in these systems is impacted by the countercations (K, Li, Na), and molecular dynamics simulations have predicted their distributions in selected cases. Formation of uranyl cages prevents hydrolysis reactions that would result in formation of insoluble uranyl solids under alkaline conditions, and these spherical clusters reach concentrations that require close packing in solution...
January 11, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28065555/stability-of-endogenous-ghb-in-vitreous-humor-vs-peripheral-blood-in-dead-bodies
#5
Francesco Paolo Busardò, Giulio Mannocchi, Raffaele Giorgetti, Manuela Pellegrini, Giovanni Baglio, Simona Zaami, Enrico Marinelli, Simona Pichini
For the first time, the stability of GHB was tested in post-mortem peripheral blood and vitreous humor samples, collected from 22 dead bodies at two different times: at the external body examination at the place of death and then during autopsy. An ad hoc method for the detection and quantification of GHB in vitreous humor by gas chromatography coupled to mass spectrometry (GC-MS) was developed and validated, with a good linearity between 0.1 and 50μg/mL (r(2)=0.991) and a precision and accuracy always better than 10% and an analytical recovery higher than 90%...
December 26, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28039581/microrna-expression-profiles-of-human-ipscs-differentiation-into-insulin-producing-cells
#6
Guido Sebastiani, Marco Valentini, Giuseppina Emanuela Grieco, Giuliana Ventriglia, Laura Nigi, Francesca Mancarella, Silvia Pellegrini, Gianvito Martino, Valeria Sordi, Lorenzo Piemonti, Francesco Dotta
AIMS: MicroRNAs are a class of small noncoding RNAs, which control gene expression by inhibition of mRNA translation. MicroRNAs are involved in the control of biological processes including cell differentiation. Here, we aim at characterizing microRNA expression profiles during differentiation of human induced pluripotent stem cells (hiPSCs) into insulin-producing cells. METHODS: We differentiated hiPSCs toward endocrine pancreatic lineage following a 18-day protocol...
December 30, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/28036017/are-treated-celiac-patients-at-risk-for-mycotoxins-an-italian-case-study
#7
Martina Cirlini, Teresa Mazzeo, Leda Roncoroni, Vincenza Lombardo, Luca Elli, Maria T Bardella, Carlo Agostoni, Luisa Doneda, Furio Brighenti, Chiara Dall'Asta, Nicoletta Pellegrini
Urinary biomarkers of mycotoxin exposure were evaluated in a group of celiac patients (n = 55) and in a control group of healthy subjects (n = 50) following their habitual diet. Deoxynivalenol (DON), zearalenone (ZEN), and fumonisin B1 (FB1) were monitored in 105 urinary samples collected from the two groups. Dietary habits were also recorded through compilation of a seven-day weighed dietary diary. Biomarkers of mycotoxin exposure were detected in 21 celiac patients and in 15 control subjects, corresponding to about 34% of total participants...
December 28, 2016: Toxins
https://www.readbyqxmd.com/read/28029748/physical-activity-minimum-threshold-predicting-improved-function-in-adults-with-lower-limb-symptoms
#8
Dorothy D Dunlop, Jing Song, Jungwha Lee, Abigail L Gilbert, Pamela A Semanik, Linda Ehrlich-Jones, Christine A Pellegrini, Daniel Pinto, Barbara Ainsworth, Rowland W Chang
OBJECTIVES: The objective is to identify an evidence-based minimum physical activity threshold to predict improved or sustained high function for adults with lower limb joint symptoms. METHODS: Prospective multi-site data from 1629 adults aged 49 years or older with symptomatic lower limb joint pain/aching/stiffness participating in Osteoarthritis Initiative accelerometer monitoring substudy were clinically assessed two years apart. Improved/high function in 2-year gait speed and patient-reported outcomes (PRO) were based on improving or remaining in the best (i...
December 28, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/28028040/whole-genome-expression-analysis-of-mammalian-wide-interspersed-repeat-elements-in-human-cell-lines
#9
Davide Carnevali, Anastasia Conti, Matteo Pellegrini, Giorgio Dieci
With more than 500,000 copies, mammalian-wide interspersed repeats (MIRs), a sub-group of SINEs, represent ∼2.5% of the human genome and one of the most numerous family of potential targets for the RNA polymerase (Pol) III transcription machinery. Since MIR elements ceased to amplify ∼130 myr ago, previous studies primarily focused on their genomic impact, while the issue of their expression has not been extensively addressed. We applied a dedicated bioinformatic pipeline to ENCODE RNA-Seq datasets of seven human cell lines and, for the first time, we were able to define the Pol III-driven MIR transcriptome at single-locus resolution...
December 27, 2016: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28026944/mdanse-an-interactive-analysis-environment-for-molecular-dynamics-simulations
#10
G Goret, B Aoun, E Pellegrini
The MDANSE software-Molecular Dynamics Analysis of Neutron Scattering Experiments-is presented. It is an interactive application for postprocessing molecular dynamics (MD) simulations. Given the widespread use of MD simulations in material and biomolecular sciences to get a better insight for experimental techniques such as thermal neutron scattering (TNS), the development of MDANSE has focused on providing a user-friendly, interactive, graphical user interface for analyzing many trajectories in the same session and running several analyses simultaneously independently of the interface...
January 6, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28009402/choroidal-characteristics-of-acute-and-chronic-central-serous-chorioretinopathy-using-enhanced-depth-imaging-optical-coherence-tomography
#11
Jorge Ruiz-Medrano, Marco Pellegrini, Matteo G Cereda, Mario Cigada, Giovanni Staurenghi
PURPOSE: Central serous chorioretinopathy (CSC) is an idiopathic disorder characterized by serous detachments of the neurosensory retina and/or the retinal pigment epithelium affecting the macular area in the majority of cases. The objective of this study was to describe choroidal findings in patients with acute and chronic CSC based on enhanced depth imaging optical coherence tomography analysis. METHODS: This is a cross-sectional, noninterventional study performed at Luigi Sacco University Hospital of Milan...
November 18, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28002153/do-inactive-older-adults-who-increase-physical-activity-experience-less-disability-evidence-from-the-osteoarthritis-initiative
#12
Jing Song, Abigail L Gilbert, Rowland W Chang, Christine A Pellegrini, Linda S Ehrlich-Jones, Jungwha Lee, Daniel Pinto, Pamela A Semanik, Leena Sharma, C Kent Kwoh, Rebecca D Jackson, Dorothy D Dunlop
BACKGROUND: Physical inactivity is a leading risk factor for developing disability. Although randomized clinical trials have demonstrated improving physical activity can reduce this risk in older adults with arthritis, these studies did not specifically evaluate inactive adults. OBJECTIVES: The aim of this study was to evaluate the relationship of changes in physical activity with disability changes among initially inactive adults with or at high risk of knee osteoarthritis from Osteoarthritis Initiative...
January 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27995756/identification-of-mir-31-5p-mir-141-3p-mir-200c-3p-and-glt1-as-human-liver-aging-markers-sensitive-to-donor-recipient-age-mismatch-in-transplants
#13
Miriam Capri, Fabiola Olivieri, Catia Lanzarini, Daniel Remondini, Vincenzo Borelli, Raffaella Lazzarini, Laura Graciotti, Maria Cristina Albertini, Elena Bellavista, Aurelia Santoro, Fiammetta Biondi, Enrico Tagliafico, Elena Tenedini, Cristina Morsiani, Grazia Pizza, Francesco Vasuri, Antonietta D'Errico, Alessandro Dazzi, Sara Pellegrini, Alessandra Magenta, Marco D'Agostino, Maurizio C Capogrossi, Matteo Cescon, Maria Rita Rippo, Antonio Domenico Procopio, Claudio Franceschi, Gian Luca Grazi
To understand why livers from aged donors are successfully used for transplants, we looked for markers of liver aging in 71 biopsies from donors aged 12-92 years before transplants and in 11 biopsies after transplants with high donor-recipient age-mismatch. We also assessed liver function in 36 age-mismatched recipients. The major findings were the following: (i) miR-31-5p, miR-141-3p, and miR-200c-3p increased with age, as assessed by microRNAs (miRs) and mRNA transcript profiling in 12 biopsies and results were validated by RT-qPCR in a total of 58 biopsies; (ii) telomere length measured by qPCR in 45 samples showed a significant age-dependent shortage; (iii) a bioinformatic approach combining transcriptome and miRs data identified putative miRs targets, the most informative being GLT1, a glutamate transporter expressed in hepatocytes...
December 20, 2016: Aging Cell
https://www.readbyqxmd.com/read/27995504/phenylpropanoids-are-key-players-in-the-antioxidant-defense-to-ozone-of-european-ash-fraxinus-excelsior
#14
Lorenzo Cotrozzi, Alessandra Campanella, Elisa Pellegrini, Giacomo Lorenzini, Cristina Nali, Elena Paoletti
Physiological and biochemical responses to ozone (O3) (150 ppb, 8 h day(-1), 35 consecutive days) of two Italian provenances (Piedmont and Tuscany) of Fraxinus excelsior L. were evaluated, with special attention to the role of phenylpropanoids. Our results indicate (i) the high O3 sensitivity especially of Piedmont provenance (in terms of visible injury, water status, and photosynthetic apparatus); (ii) although the intra-specific sensitivity to O3 between provenances differs (mainly due to different stomatal behaviors since only Tuscany plants partially avoided the uptake of the pollutant gas), both provenances showed detoxification and defense mechanisms; (iii) the crucial participation of phenylpropanoids, with a key role played by flavonoids (especially quercitrin): among this class of metabolites, isoquercitrin is the principal player in the lower O3 sensitivity of Tuscany plants, together with lignins; (iv) although coumarins (typical compounds of Fraxinus) were severely depressed by O3, isofraxidin was triggered suggesting a key role in reactive oxygen species (ROS) detoxification, as well as trans-chalcone...
December 19, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27989715/human-embryonic-stem-cells-do-not-change-their-x-inactivation-status-during-differentiation
#15
Sanjeet Patel, Giancarlo Bonora, Anna Sahakyan, Rachel Kim, Constantinos Chronis, Justin Langerman, Sorel Fitz-Gibbon, Liudmilla Rubbi, Rhys J P Skelton, Reza Ardehali, Matteo Pellegrini, William E Lowry, Amander T Clark, Kathrin Plath
Applications of embryonic stem cells (ESCs) require faithful chromatin changes during differentiation, but the fate of the X chromosome state in differentiating ESCs is unclear. Female human ESC lines either carry two active X chromosomes (XaXa), an Xa and inactive X chromosome with or without XIST RNA coating (Xi(XIST+)Xa;XiXa), or an Xa and an eroded Xi (XeXa) where the Xi no longer expresses XIST RNA and has partially reactivated. Here, we established XiXa, XeXa, and XaXa ESC lines and followed their X chromosome state during differentiation...
January 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/27980751/a-case-of-veno-venous-extracorporeal-membrane-oxygenation-for-severe-respiratory-failure-in-a-superobese-patient
#16
Mirko Belliato, Luca Cremascoli, Anna Aliberti, Michele Pagani, Carlo Pellegrini, Giorgio Antonio Iotti
After risk assessment, veno-venous extracorporeal membrane oxygenation (ECMO) has been achieved in a superobese adult patient as a bridge to recovery of respiratory failure, despite the weight-related difficulties. Early v-v ECMO implantation could be considered to support and to conduct weaning both from sedation and from invasive mechanical ventilation, with the goal to perform physiokinesitherapy during awake ECMO.
December 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27974214/optic-atrophy-1-is-epistatic-to-the-core-micos-component-mic60-in-mitochondrial-cristae-shape-control
#17
Christina Glytsou, Enrique Calvo, Sara Cogliati, Arpit Mehrotra, Irene Anastasia, Giovanni Rigoni, Andrea Raimondi, Norihito Shintani, Marta Loureiro, Jesùs Vazquez, Luca Pellegrini, Jose Antonio Enriquez, Luca Scorrano, Maria Eugenia Soriano
The mitochondrial contact site and cristae organizing system (MICOS) and Optic atrophy 1 (OPA1) control cristae shape, thus affecting mitochondrial function and apoptosis. Whether and how they physically and functionally interact is unclear. Here, we provide evidence that OPA1 is epistatic to MICOS in the regulation of cristae shape. Proteomic analysis identifies multiple MICOS components in native OPA1-containing high molecular weight complexes disrupted during cristae remodeling. MIC60, a core MICOS protein, physically interacts with OPA1, and together, they control cristae junction number and stability, OPA1 being epistatic to MIC60...
December 13, 2016: Cell Reports
https://www.readbyqxmd.com/read/27970145/tct-760-predictors-of-elevated-tumor-marker-carbohydrate-antigen-125-in-patients-undergoing-transcatheter-aortic-valve-implantation
#18
Tobias Rheude, Costanza Pellegrini, Teresa Trenkwalder, Jonathan Michel, Markus Kasel, Heribert Schunkert, Adnan Kastrati, Christian Hengstenberg, Oliver Husser
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970111/tct-730-a-multicenter-analysis-of-incidence-and-predictors-for-permanent-pacemaker-implantations-and-new-conduction-abnormalities-with-a-novel-self-expandable-transcatheter-heart-valve
#19
Costanza Pellegrini, Oliver Husser, Won Kim, Andreas Holzamer, Thomas Walther, Tobias Rheude, Teresa Trenkwalder, Jonathan Michel, Adnan Kastrati, Heribert Schunkert, Christof Burgdorf, Michael Hilker, Helge Möllmann, Christian Hengstenberg
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970094/tct-714-incidental-findings-in-multislice-ct-for-procedural-planning-in-transcatheter-aortic-valve-implantation-prevalence-clinical-relevance-and-outcome
#20
Teresa Trenkwalder, Anna Lena Lahmann, Costanza Pellegrini, Magdalena Nowicka, Tobias Rheude, N Patrick Mayr, Sabine Bleiziffer, Ruediger Lange, Heribert Schunkert, Markus Kasel, Adnan Kastrati, Oliver Husser, Martin Hadamitzky, Christian Hengstenberg
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
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