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https://www.readbyqxmd.com/read/28329683/inactivation-of-ezh2-upregulates-gfi1-and-drives-aggressive-myc-driven-group-3-medulloblastoma
#1
BaoHan T Vo, Chunliang Li, Marc A Morgan, Ilan Theurillat, David Finkelstein, Shaela Wright, Judith Hyle, Stephanie M C Smith, Yiping Fan, Yong-Dong Wang, Gang Wu, Brent A Orr, Paul A Northcott, Ali Shilatifard, Charles J Sherr, Martine F Roussel
The most aggressive of four medulloblastoma (MB) subgroups are cMyc-driven group 3 (G3) tumors, some of which overexpress EZH2, the histone H3K27 mono-, di-, and trimethylase of polycomb-repressive complex 2. Ezh2 has a context-dependent role in different cancers as an oncogene or tumor suppressor and retards tumor progression in a mouse model of G3 MB. Engineered deletions of Ezh2 in G3 MBs by gene editing nucleases accelerated tumorigenesis, whereas Ezh2 re-expression reversed attendant histone modifications and slowed tumor progression...
March 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/28329057/coronary-artery-calcification-and-risk-of-cardiovascular-disease-and-death-among-patients-with-chronic-kidney-disease
#2
Jing Chen, Matthew J Budoff, Muredach P Reilly, Wei Yang, Sylvia E Rosas, Mahboob Rahman, Xiaoming Zhang, Jason A Roy, Eva Lustigova, Lisa Nessel, Virginia Ford, Dominic Raj, Anna C Porter, Elsayed Z Soliman, Jackson T Wright, Myles Wolf, Jiang He
Importance: Coronary artery calcification (CAC) is highly prevalent in dialysis-naive patients with chronic kidney disease (CKD). However, there are sparse data on the association of CAC with subsequent risk of cardiovascular disease and all-cause mortality in this population. Objective: To study the prospective association of CAC with risk of cardiovascular disease and all-cause mortality among dialysis-naive patients with CKD. Design, Setting, and Participants: The prospective Chronic Renal Insufficiency Cohort study recruited adults with an estimated glomerular filtration rate of 20 to 70 mL/min/1...
March 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28328643/implementation-of-an-evidence-based-content-validated-standardized-ostomy-algorithm-tool-in-home-care-a-quality-improvement-project
#3
Kimberly Bare, Jerri Drain, Monica Timko-Progar, Bobbie Stallings, Kimberly Smith, Naomi Ward, Sandra Wright
Many nurses have limited experience with ostomy management. We sought to provide a standardized approach to ostomy education and management to support nurses in early identification of stomal and peristomal complications, pouching problems, and provide standardized solutions for managing ostomy care in general while improving utilization of formulary products. This article describes development and testing of an ostomy algorithm tool.
March 22, 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28328278/returning-to-the-gym-with-a-stoma-a-patient-s-perspective
#4
Zoey Wright
Zoey Wright shares her experiences of adjusting to life with a stoma and how she overcame the practical and psychological challenges it posed.
March 9, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28327893/bcl2-expression-but-not-myc-and-bcl2-coexpression-predicts-survival-in-elderly-patients-with-diffuse-large-b-cell-lymphoma-independently-of-cell-of-origin-in-the-phase-3-lnh03-6b-trial
#5
T Petrella, C Copie-Bergman, J Brière, R Delarue, F Jardin, P Ruminy, C Thieblemont, M Figeac, D Canioni, P Feugier, B Fabiani, K Leroy, M Parrens, M André, C Haioun, G A Salles, P Gaulard, H Tilly, J P Jais, T J Molina
Background: Our aim was to evaluate whether the cell of origin (COO) as defined by the Hans algorithm and MYC/BCL2 coexpression, which are the two main biological risk factors in elderly patients treated with rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisolone (R-CHOP), maintain their prognostic value in a large prospective clinical trial. Patients and Methods: We evaluated 285 paraffin-embedded samples from patients (60-80 years of age) enrolled in the Lymphoma Study Association (LYSA) trial LNH03-6B who were treated with R-CHOP...
January 24, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28326963/the-stillbirth-classification-system-for-the-safe-passage-study
#6
Theonia K Boyd, Colleen A Wright, Hein J Odendaal, Amy J Elliott, Mary Ann Sens, Rebecca D Folkerth, Drucilla J Roberts, Hannah C Kinney
Objective Describe the classification system for assigning the cause of stillbirth in the Safe Passage Study, an international, multi-institutional, prospective analysis conducted by the NIAAA/NICHD-funded Prenatal Alcohol in SIDS and Stillbirth (PASS) Research Network. The study mission is to determine the role of prenatal alcohol and/or cigarette smoke exposure in adverse pregnancy outcomes, including stillbirth, in a high-risk cohort of 12,000 maternal/fetal dyads. Methods The PASS Network classification system is based upon 5 "sites of origin" for cause of stillbirth, further subdivided into mechanism subcategories; both are employed to assign an ultimate cause of death...
March 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28325879/experimental-comparison-of-two-quantum-computing-architectures
#7
Norbert M Linke, Dmitri Maslov, Martin Roetteler, Shantanu Debnath, Caroline Figgatt, Kevin A Landsman, Kenneth Wright, Christopher Monroe
We run a selection of algorithms on two state-of-the-art 5-qubit quantum computers that are based on different technology platforms. One is a publicly accessible superconducting transmon device (www. RESEARCH: ibm.com/ibm-q) with limited connectivity, and the other is a fully connected trapped-ion system. Even though the two systems have different native quantum interactions, both can be programed in a way that is blind to the underlying hardware, thus allowing a comparison of identical quantum algorithms between different physical systems...
March 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28325637/long-term-control-of-oligometastatic-prostate-cancer-after-stereotactic-body-radiotherapy-in-the-absence-of-androgen-deprivation-therapy-a%C3%A2-case-report
#8
Mark C Markowski, Philip Imus, Jean L Wright, Douglas Schottenstein, Channing J Paller
No abstract text is available yet for this article.
February 27, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28324499/telomere-terminal-g-c-strand-synthesis-measuring-telomerase-action-and-c-rich-fill-in
#9
Yong Zhao, Jerry W Shay, Woodring E Wright
Telomerase is present in most human cancers, and proliferative stem cells including germline cells. Telomerase plays an essential role in tumorigenesis by maintaining/elongating telomeric DNA, and thus preventing the telomere shortening that results in replicative senescence. Understanding telomerase action in vivo has important implication for both cancer and aging, but there are not robust methods for monitoring telomerase action. By combining a series of cell biological and biochemical approaches, and taking advantage of the enzyme DSN that specifically cuts double-stranded DNA and releases the telomeric overhangs, we have developed a method to monitor telomerase action during one cell cycle...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28324497/telomere-g-rich-overhang-length-measurement-dsn-method
#10
Yong Zhao, Jerry W Shay, Woodring E Wright
Telomeres terminate in 3' single-stranded G-rich overhangs that function in telomere end protection and telomerase action. An accurate measurement of overhang length is challenging due to the presence of many kilobases of double-stranded telomere DNA. Here, a simple method is described that utilizes duplex specific nuclease (DSN) to digest all double-stranded DNA including telomeres to fragments of <10 bp, leaving the single-stranded overhangs intact. Their length can then be determined by Southern blot using super-sensitive telomere C-rich probes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28323771/an-exception-to-the-rule-or-a-rule-for-the-exception-the-potential-of-using-hiv-positive-donors-in-canada
#11
Alissa J Wright, Caren Rose, Maeghan Toews, Michel Paquet, Daniel Corsilli, Jean-François Le Cailhier, John S Gill
Selected human immunodeficiency virus (HIV)-infected patients with end organ failure can safely receive an organ transplant from an HIV uninfected donor. Recent demonstration of the short term safety of organ transplantation between HIV-infected persons prompted a change in US American law to allow such transplantations. Prompted by the recent completion of the first organ transplantation between HIV-infected persons in Canada, we review Canadian law regarding the use of organs from HIV-infected donors, estimate the number of potential HIV-infected donors in Canada, and critically review considerations related to advancing organ transplantation from HIV-infected donors in Canada...
April 2017: Transplantation
https://www.readbyqxmd.com/read/28323586/home-cervical-traction-to-reduce-neck-pain-in-fighter-pilots
#12
Eric M Chumbley, Nicole O'Hair, Adrienne Stolfi, Christopher Lienesch, James C McEachen, Bruce A Wright
INTRODUCTION: Most fighter pilots report cervical pain during their careers. Recommendations for remediation lack evidence. We sought to determine whether regular use of a home cervical traction device could decrease reported cervical pain in F-15C pilots. METHODS: An institutional review board-approved, Health Insurance Portability and Accountability Act-compliant, controlled crossover study was undertaken with 21 male F-15C fighter pilots between February and June 2015...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28323185/geopolitical-forces-and-the-challenges-for-developing-world-neurosurgery-training
#13
Ernest J Wright, Peter Nakaji
No abstract text is available yet for this article.
March 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28322987/an-experimental-examination-of-the-effort-reward-imbalance-model-of-occupational-stress-increased-financial-reward-is-related-to-reduced-stress-physiology
#14
Kathleen Landolt, Emma O'Donnell, Agnes Hazi, Nico Dragano, Bradley J Wright
Effort-reward imbalance in the workplace is linked to a variety of negative health and organisational outcomes, but it has rarely been assessed experimentally. We manipulated reward (while keeping effort constant) in a within-subjects design with female participants (N= 60) who were randomly assigned to high and standard reward conditions within a simulated office environment. Self-report, behavioural (task performance), and physiological (heart rate variability, salivary alpha amylase) measures assessed the impact of increased financial reward...
March 16, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28322868/inclusive-fitness-analysis-of-cumulative-cultural-evolution-in-an-island-structured-population
#15
Hisashi Ohtsuki, Joe Yuichiro Wakano, Yutaka Kobayashi
The success of humans on the globe is largely supported by our cultural excellence. Our culture is cumulative, meaning that it is improved from generation to generation. Previous works have revealed that two modes of learning, individual learning and social learning, play pivotal roles in the accumulation of culture. However, under the trade-off between learning and reproduction, one's investment into learning is easily exploited by those who copy the knowledge of skillful individuals and selfishly invest more efforts in reproduction...
March 16, 2017: Theoretical Population Biology
https://www.readbyqxmd.com/read/28322782/cl-316-243-mediated-reductions-in-blood-glucose-are-enhanced-in-rip140-mice-independent-of-alterations-in-lipolysis
#16
Willem T Peppler, Paula M Miotto, Graham P Holloway, David C Wright
The β-3 adrenergic agonist CL 316, 243 acutely lowers blood glucose through a mechanism thought to involve fatty-acid induced insulin release. The purpose of this study was to determine if ablation of the nuclear receptor, receptor-inactivating protein 140 (RIP140), altered this response. Here, we used a single injection of CL 316, 243 (1 mg/kg) and found that whole body RIP140(-/-) mice had a greater decline in blood glucose over 2 h. This occurred alongside increased hexokinase II (HKII) protein content in adipose tissue and skeletal muscle, but independent of changes in circulating insulin or indices of lipolysis...
March 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28321477/total-knee-arthroplasty-after-varus-distal-femoral-osteotomy-vs-native-knee-similar-results-in-a-case-control-study
#17
Romain Gaillard, Timothy Lording, Sebastien Lustig, Elvire Servien, Philippe Neyret
PURPOSE: The aim of this study was to investigate the results of total knee arthroplasty (TKA) performed after varus distal femoral osteotomy (VrDFO), in comparison to a control group of TKAs performed as the primary intervention for arthrosis. Main hypothesis was that the medium term results for the two groups would be similar. METHODS: All TKAs performed after VrDFO were extracted from a single centre, prospective database of 4046 arthroplasties. A case-control study was performed with a control group comprising two TKAs performed as the primary intervention for each TKA after VrDFO, and matched for sex, age at intervention, body mass index, the type of arthrosis and the type of implant...
March 20, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28321423/the-anterolateral-ligament-an-anatomic-study-on-sex-based-differences
#18
Matt Daggett, Camilo Helito, Matthew Cullen, Andrew Ockuly, Kyle Busch, Joseph Granite, Barth Wright, Bertrand Sonnery-Cottet
BACKGROUND: The anterolateral ligament (ALL) has been shown to have an important role in rotatory stability of the knee. While there is abundant research on sex-based differences related to anterior cruciate ligament (ACL) rupture, there is a paucity of literature related to such differences in the ALL. PURPOSE: To define any sex-based differences in the ALL with regard to length, width, and thickness. STUDY DESIGN: Descriptive laboratory study...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28321357/factors-associated-with-poststroke-anxiety-a-systematic-review-and-meta-analysis
#19
REVIEW
Francesca Wright, Simiao Wu, Ho-Yan Yvonne Chun, Gillian Mead
Background and Purpose. Anxiety affects 25% of stroke survivors. There are no effective treatments. Poststroke depression, prestroke anxiety and depression, locus of control, coping, confidence, fatigue, and sleep are factors that may be associated with poststroke anxiety and can potentially be targeted by therapy. We systematically reviewed the literature and performed a meta-analysis to identify associations with these factors. Methods. We searched electronic databases from January 2014 to July 2015 to complement a literature search performed from inception to May 2014...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28320384/diagnostic-accuracy-incremental-yield-and-prognostic-value-of-determine-tb-lam-for-routine-diagnostic-testing-for-tuberculosis-in-hiv-infected-patients-requiring-acute-hospital-admission-in-south-africa-a-prospective-cohort
#20
Stephen D Lawn, Andrew D Kerkhoff, Rosie Burton, Charlotte Schutz, Andrew Boulle, Monica Vogt, Ankur Gupta-Wright, Mark P Nicol, Graeme Meintjes
BACKGROUND: We previously reported that one-third of HIV-positive adults requiring medical admission to a South African district hospital had laboratory-confirmed tuberculosis (TB) and that almost two-thirds of cases could be rapidly diagnosed using Xpert MTB/RIF-testing of concentrated urine samples obtained on the first day of admission. Implementation of urine-based, routine, point-of-care TB screening is an attractive intervention that might be facilitated by use of a simple, low-cost diagnostic tool, such as the Determine TB-LAM lateral-flow rapid test for HIV-associated TB...
March 21, 2017: BMC Medicine
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