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https://www.readbyqxmd.com/read/28544480/obesity-as-a-risk-factor-for-developing-functional-limitation-among-older-adults-a-conditional-inference-tree-analysis
#1
Feon W Cheng, Xiang Gao, Le Bao, Diane C Mitchell, Craig Wood, Martin J Sliwinski, Helen Smiciklas-Wright, Christopher D Still, David D K Rolston, Gordon L Jensen
OBJECTIVE: To examine the risk factors of developing functional decline and make probabilistic predictions by using a tree-based method that allows higher order polynomials and interactions of the risk factors. METHODS: The conditional inference tree analysis, a data mining approach, was used to construct a risk stratification algorithm for developing functional limitation based on BMI and other potential risk factors for disability in 1,951 older adults without functional limitations at baseline (baseline age 73...
May 24, 2017: Obesity
https://www.readbyqxmd.com/read/28543044/quantification-of-body-iron-and-iron-absorption-in-the-reds-ii-donor-iron-status-evaluation-rise-study
#2
Joseph E Kiss, Rebecca J Birch, Whitney R Steele, David J Wright, Ritchard G Cable
BACKGROUND: Repeated blood donation alters the iron balance of blood donors. We quantified these effects by analyzing changes in body iron as well as calculating iron absorbed per day for donors enrolled in a prospective study. STUDY DESIGN AND METHODS: For 1308 donors who completed a final study visit, we calculated total body iron at the enrollment and final visits and the change in total body iron over the course of the study. Taking into account iron lost from blood donations during the study and obligate losses, we also calculated the average amount of iron absorbed per day...
May 19, 2017: Transfusion
https://www.readbyqxmd.com/read/28542152/corrigendum-brain-feminization-requires-active-repression-of-masculinization-via-dna-methylation
#3
Bridget M Nugent, Christopher L Wright, Amol C Shetty, Georgia E Hodes, Kathryn M Lenz, Anup Mahurkar, Scott J Russo, Scott E Devine, Margaret M McCarthy
No abstract text is available yet for this article.
May 25, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28541447/handheld-tunable-focus-confocal-microscope-utilizing-a-double-clad-fiber-coupler-for-in-vivo-imaging-of-oral-epithelium
#4
Cory Olsovsky, Taylor Hinsdale, Rodrigo Cuenca, Yi-Shing Lisa Cheng, John M Wright, Terry D Rees, Javier A Jo, Kristen C Maitland
No abstract text is available yet for this article.
May 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28541372/the-oral-health-status-of-older-patients-in-acute-care-on-admission-and-day-7-in-two-australian-hospitals
#5
Jennifer Mary Gibney, Clive Wright, Anita Sharma, Mario D'Souza, Vasi Naganathan
Objective: to determine the oral health status of older patients in acute care wards at admission and after 7 days. Methods: a prospective descriptive study was conducted in two acute tertiary referral hospitals in New South Wales, Australia. Oral health was assessed on admission (within 24 h) and Day 7 using the Oral Health Assessment Tool. Results: a total of 575 patients were admitted under the Geriatric teams at the two hospitals. Four hundred and thirty-five (76%) patients had oral cleanliness (debris) scores in the 'not healthy' range with food particles, tartar or plaque evident in at least one area in most areas of the mouth, teeth or dentures...
May 25, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28541136/metrics-beyond-hemoglobin-a1c-in-diabetes-management-time-in-range-hypoglycemia-and-other-parameters
#6
Lorena Alarcon-Casas Wright, Irl B Hirsch
We review clinical instances in which A1C should not be used and reflect on the use of other glucose metrics that can be used, in substitution of or in combination with A1C and SMBG, to tailor an individualized approach that will result in better outcomes and patient empowerment.
May 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28541135/clinical-use-of-professional-continuous-glucose-monitoring
#7
Eugene E Wright, James R Gavin
No abstract text is available yet for this article.
May 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28540645/the-effect-of-access-to-information-on-beliefs-surrounding-breast-cancer-in-south-africa
#8
Sarah Rayne, Kathryn Schnippel, Carol Benn, Deirdre Kruger, Kathryne Wright, Cynthia Firnhaber
Breast cancer is the most common cancer affecting women in South Africa. There is little knowledge of beliefs to help identify key areas to improve support and education in this demographically and culturally diverse population. Women with a variety of demographic and socioeconomic characteristics accessing care for breast cancer were asked their agreement to statements of knowledge and beliefs about breast cancer. Of the 259 participants, positive statements of medical cure (87.9%) and family support (90.5%) were most commonly believed...
May 24, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28540506/assessing-the-feasibility-of-the-effectiveness-of-discontinuing-bisphosphonates-trial-a-pilot-study
#9
N C Wright, P J Foster, A S Mudano, J A Melnick, M E Lewiecki, W J Shergy, J R Curtis, G R Cutter, M I Danila, M L Kilgore, E C Lewis, S L Morgan, D T Redden, A H Warriner, K G Saag
The Effectiveness of Discontinuing Bisphosphonates (EDGE) study is a planned pragmatic clinical trial to guide "drug holiday" clinical decision making. This pilot study assessed work flow and feasibility of such a study. While participant recruitment and treatment adherence were suboptimal, administrative procedures were generally feasible and minimally disrupted clinic flow. INTRODUCTION: The comparative effectiveness of continuing or discontinuing long-term alendronate (ALN) on fractures is unknown...
May 24, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28540340/is-childhood-socioeconomic-status-related-to-coronary-heart-disease-evidence-from-the-health-and-retirement-study-1992-2012
#10
Minjee Lee, M Mahmud Khan, Brad Wright
Objective: We investigated the association between childhood socioeconomic status (SES) and coronary heart disease (CHD) in older Americans. Method: We used Health and Retirement Study data from 1992 to 2012 to examine a nationally representative sample of Americans aged ≥50 years (N = 30,623). We modeled CHD as a function of childhood and adult SES using maternal and paternal educational level as a proxy for childhood SES. Results: Respondents reporting low childhood SES were significantly more likely to have CHD than respondents reporting high childhood SES...
January 2017: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/28538134/trial-of-cannabidiol-for-drug-resistant-seizures-in-the-dravet-syndrome
#11
Orrin Devinsky, J Helen Cross, Linda Laux, Eric Marsh, Ian Miller, Rima Nabbout, Ingrid E Scheffer, Elizabeth A Thiele, Stephen Wright
BACKGROUND: The Dravet syndrome is a complex childhood epilepsy disorder that is associated with drug-resistant seizures and a high mortality rate. We studied cannabidiol for the treatment of drug-resistant seizures in the Dravet syndrome. METHODS: In this double-blind, placebo-controlled trial, we randomly assigned 120 children and young adults with the Dravet syndrome and drug-resistant seizures to receive either cannabidiol oral solution at a dose of 20 mg per kilogram of body weight per day or placebo, in addition to standard antiepileptic treatment...
May 25, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28538116/case-16-2017-a-69-year-old-woman-with-urinary-incontinence
#12
Jason D Wright, John O Schorge, Aoife Kilcoyne, Rosemary H Tambouret
Presentation of Case. Dr. John O. Schorge: A 69-year-old woman was evaluated at the gynecologic oncology clinic of this hospital because of persistent urinary incontinence. Seven years before this evaluation, the patient had received a diagnosis of superficial bladder cancer (low grade), for which..
May 25, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28537965/the-affordable-care-act-and-end-of-life-care-for-patients-with-cancer
#13
Ravi B Parikh, Alexi A Wright
The Affordable Care Act (ACA) expanded access to high-quality end-of-life care for Americans with serious illness, including cancer. Before the ACA was enacted in 2010, nearly 715,000 patients died in hospitals annually, despite evidence that most Americans prefer to die at home. Moreover, fewer than half of Medicare beneficiaries used hospice before death, despite evidence that hospice services improve cancer patients' quality of life near death and caregivers' bereavement outcomes. The ACA-stipulated programs and subsequent efforts were designed to address these deficiencies in access to high-quality end-of-life care...
May 2017: Cancer Journal
https://www.readbyqxmd.com/read/28537805/pathology-of-chronic-hypersensitivity-pneumonitis-what-is-it-what-are-the-diagnostic-criteria-why-do-we-care
#14
Andrew Churg, AnaMaria Bilawich, Joanne L Wright
CONTEXT: - Chronic hypersensitivity pneumonitis (CHP) has emerged from obscurity during the past 15 years and is now recognized as a very common form of fibrosing interstitial pneumonia but one that is frequently misdiagnosed both clinically and on surgical lung biopsy as usual interstitial pneumonia/idiopathic pulmonary fibrosis (UIP/IPF) or fibrotic nonspecific interstitial pneumonia. OBJECTIVE: - To review the pathologic features of CHP. DATA SOURCES: - Clinical, pathology, and radiology literature were used...
May 24, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28537353/low-ankle-sprains-a-current-review-of-diagnosis-and-treatment
#15
Anthony J Scillia, Todd P Pierce, Kimona Issa, Craig Wright, John J Callaghan, Anthony Festa, Vincent K McInerney
LLow ankle sprains are common injuries in young athletes. Hence, it is imperative that low ankle sprains are diagnosed and treated quickly and effectively. We reviewed the: (1) anatomy; (2) imaging; (3) physical exam findings; and (4) treatment modalities regarding these injuries. Plain radiographs are standard of care and routine MRI is not recommended for suspected sprains. However, physical exam findings often may guide management decisions. The majority of patients diagnosed with low ankle sprains are treated with a one- to two-week immobilization period with physical therapy focused on peroneal proprioception and strength...
May 24, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28536590/miniature-inverted-repeat-transposable-element-insertions-provide-a-source-of-intron-length-polymorphism-markers-in-the-carrot-daucus-carota-l
#16
Katarzyna Stelmach, Alicja Macko-Podgórni, Gabriela Machaj, Dariusz Grzebelus
The prevalence of non-autonomous class II transposable elements (TEs) in plant genomes may serve as a tool for relatively rapid and low-cost development of gene-associated molecular markers. Miniature inverted-repeat transposable element (MITE) copies inserted within introns can be exploited as potential intron length polymorphism (ILP) markers. ILPs can be detected by PCR with primers anchored in exon sequences flanking the target introns. Here, we designed primers for 209 DcSto (Daucus carota Stowaway-like) MITE insertion sites within introns along the carrot genome and validated them as candidate ILP markers in order to develop a set of markers for genotyping the carrot...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28535806/the-past-matters-estimating-intrinsic-hookworm-transmission-intensity-in-areas-with-past-mass-drug-administration-to-control-lymphatic-filariasis
#17
Marleen Werkman, James E Truscott, Jaspreet Toor, James E Wright, Roy M Anderson
BACKGROUND: Current WHO guidelines for soil-transmitted helminth (STH) control focus on mass drug administration (MDA) targeting preschool-aged (pre-SAC) and school-aged children (SAC), with the goal of eliminating STH as a public health problem amongst children. Recently, attention and funding has turned towards the question whether MDA alone can result in the interruption of transmission for STH. The lymphatic filariasis (LF) elimination programme, have been successful in reaching whole communities...
May 23, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28535186/fxr-gankyrin-axis-is-involved-in-development-of-pediatric-liver-cancer
#18
Leila Valanejad, Kyle Lewis, Mary Wright, Yanjun Jiang, Amber D'Souza, Rebekah Karns, Rachel Sheridan, Anita Gupta, Kevin Bove, David Witte, James Geller, Gregory Tiao, David L Nelson, Lubov Timchenko, Nikolai Timchenko
The development of hepatoblastoma (HBL) is associated with failure of hepatic stem cells (HSC) to differentiate into hepatocytes. Despite intensive investigations, mechanisms of the failure of HSC to differentiate are not known. We found that oncogene Gankyrin (Gank) is involved in the inhibition of differentiation of HSC via triggering degradation of tumor suppressor proteins (TSPs) Rb, p53, C/EBPα and HNF4α. Our data show that the activation of a repressor of Gank, farnesoid X receptor, FXR, after initiation of liver cancer by Diethylnitrosamine (DEN) prevents the development of liver cancer by inhibiting Gank and rescuing tumor suppressor proteins...
May 23, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28535142/srs2-promotes-synthesis-dependent-strand-annealing-by-disrupting-dna-polymerase-%C3%AE-extending-d-loops
#19
Jie Liu, Christopher Ede, William D Wright, Steven K Gore, Shirin S Jenkins, Bret D Freudenthal, M Todd Washington, Xavier Veaute, Wolf-Dietrich Heyer
Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity. Genetic analysis identified the Srs2 helicase as a prime candidate to promote SDSA. Here, we demonstrate that Srs2 disrupts D-loops in an ATP-dependent fashion and with a distinct polarity. Specifically, we partly reconstitute the SDSA pathway using Rad51, Rad54, RPA, RFC, DNA Polymerase δ with different forms of PCNA...
May 23, 2017: ELife
https://www.readbyqxmd.com/read/28534826/atp-driven-contraction-of-phage-t3-capsids-with-dna-incompletely-packaged-in-vivo
#20
Philip Serwer, Elena T Wright
Adenosine triphosphate (ATP) cleavage powers packaging of a double-stranded DNA (dsDNA) molecule in a pre-assembled capsid of phages that include T3. Several observations constitute a challenge to the conventional view that the shell of the capsid is energetically inert during packaging. Here, we test this challenge by analyzing the in vitro effects of ATP on the shells of capsids generated by DNA packaging in vivo. These capsids retain incompletely packaged DNA (ipDNA) and are called ipDNA-capsids; the ipDNA-capsids are assumed to be products of premature genome maturation-cleavage...
May 19, 2017: Viruses
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