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https://www.readbyqxmd.com/read/29341718/search-for-invisible-decays-of-a-dark-photon-produced-in-e-e-collisions-at-babar
#1
J P Lees, V Poireau, V Tisserand, E Grauges, A Palano, G Eigen, D N Brown, M Derdzinski, A Giuffrida, Yu G Kolomensky, M Fritsch, H Koch, T Schroeder, C Hearty, T S Mattison, J A McKenna, R Y So, V E Blinov, A R Buzykaev, V P Druzhinin, V B Golubev, E A Kravchenko, A P Onuchin, S I Serednyakov, Yu I Skovpen, E P Solodov, K Yu Todyshev, A J Lankford, J W Gary, O Long, A M Eisner, W S Lockman, W Panduro Vazquez, D S Chao, C H Cheng, B Echenard, K T Flood, D G Hitlin, J Kim, T S Miyashita, P Ongmongkolkul, F C Porter, M Röhrken, Z Huard, B T Meadows, B G Pushpawela, M D Sokoloff, L Sun, J G Smith, S R Wagner, D Bernard, M Verderi, D Bettoni, C Bozzi, R Calabrese, G Cibinetto, E Fioravanti, I Garzia, E Luppi, V Santoro, A Calcaterra, R de Sangro, G Finocchiaro, S Martellotti, P Patteri, I M Peruzzi, M Piccolo, M Rotondo, A Zallo, S Passaggio, C Patrignani, H M Lacker, B Bhuyan, U Mallik, C Chen, J Cochran, S Prell, H Ahmed, A V Gritsan, N Arnaud, M Davier, F Le Diberder, A M Lutz, G Wormser, D J Lange, D M Wright, J P Coleman, E Gabathuler, D E Hutchcroft, D J Payne, C Touramanis, A J Bevan, F Di Lodovico, R Sacco, G Cowan, Sw Banerjee, D N Brown, C L Davis, A G Denig, W Gradl, K Griessinger, A Hafner, K R Schubert, R J Barlow, G D Lafferty, R Cenci, A Jawahery, D A Roberts, R Cowan, S H Robertson, B Dey, N Neri, F Palombo, R Cheaib, L Cremaldi, R Godang, D J Summers, P Taras, G De Nardo, C Sciacca, G Raven, C P Jessop, J M LoSecco, K Honscheid, R Kass, A Gaz, M Margoni, M Posocco, G Simi, F Simonetto, R Stroili, S Akar, E Ben-Haim, M Bomben, G R Bonneaud, G Calderini, J Chauveau, G Marchiori, J Ocariz, M Biasini, E Manoni, A Rossi, G Batignani, S Bettarini, M Carpinelli, G Casarosa, M Chrzaszcz, F Forti, M A Giorgi, A Lusiani, B Oberhof, E Paoloni, M Rama, G Rizzo, J J Walsh, A J S Smith, F Anulli, R Faccini, F Ferrarotto, F Ferroni, A Pilloni, G Piredda, C Bünger, S Dittrich, O Grünberg, M Heß, T Leddig, C Voß, R Waldi, T Adye, F F Wilson, S Emery, G Vasseur, D Aston, C Cartaro, M R Convery, J Dorfan, W Dunwoodie, M Ebert, R C Field, B G Fulsom, M T Graham, C Hast, W R Innes, P Kim, D W G S Leith, S Luitz, D B MacFarlane, D R Muller, H Neal, B N Ratcliff, A Roodman, M K Sullivan, J Va'vra, W J Wisniewski, M V Purohit, J R Wilson, A Randle-Conde, S J Sekula, M Bellis, P R Burchat, E M T Puccio, M S Alam, J A Ernst, R Gorodeisky, N Guttman, D R Peimer, A Soffer, S M Spanier, J L Ritchie, R F Schwitters, J M Izen, X C Lou, F Bianchi, F De Mori, A Filippi, D Gamba, L Lanceri, L Vitale, F Martinez-Vidal, A Oyanguren, J Albert, A Beaulieu, F U Bernlochner, G J King, R Kowalewski, T Lueck, I M Nugent, J M Roney, R J Sobie, N Tasneem, T J Gershon, P F Harrison, T E Latham, R Prepost, S L Wu
We search for single-photon events in 53  fb^{-1} of e^{+}e^{-} collision data collected with the BABAR detector at the PEP-II B-Factory. We look for events with a single high-energy photon and a large missing momentum and energy, consistent with production of a spin-1 particle A^{'} through the process e^{+}e^{-}→γA^{'}; A^{'}→invisible. Such particles, referred to as "dark photons," are motivated by theories applying a U(1) gauge symmetry to dark matter. We find no evidence for such processes and set 90% confidence level upper limits on the coupling strength of A^{'} to e^{+}e^{-} in the mass range m_{A^{'}}≤8  GeV...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341454/socioeconomic-deprivation-and-the-burden-of-head-and-neck-cancer-regional-variations-of-incidence-and-mortality-in-merseyside-and-cheshire-north-west-england
#2
B G Taib, J Oakley, Y Dailey, I Hodge, P Wright, R du Plessis, J Rylands, D Taylor-Robinson, S Povall, A Schache, R Shaw, A Dingle, T M Jones
OBJECTIVES: The aim of this longitudinal study is to examine the distribution of head and neck cancer (HANC) disease burden across the region comparing it to national trends. DESIGN: We undertook a retrospective study of routine data combining it with indicators of deprivation and lifestyle at small geographical areas within the nine Local Authorities (LAs) of Merseyside and Cheshire Network (MCCN)for head and neck cancers. Data from the North West of England and England were used as comparator regions...
January 17, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29341237/the-impact-of-diuretic-use-and-abcg2-genotype-on-the-predictive-performance-of-a-published-allopurinol-dosing-tool
#3
Daniel F B Wright, Nicola Dalbeth, Amanda J Phipps-Green, Tony R Merriman, Murray L Barclay, Jill Drake, Paul Tan, Anne Horne, Lisa K Stamp
This research aims to evaluate the predictive performance of a published allopurinol dosing tool. Allopurinol dose predictions were compared to the actual dose required to achieve serum urate (SU) <0.36 mmol L-1 using mean prediction error. The influence of patient factors on dose predictions was explored using multilinear regression. Allopurinol doses were over-predicted by the dosing tool, however, this was minimal in patients without diuretic therapy (MPE 63mg day-1 , 95%CI 40-87) compared to those receiving diuretics (MPE 295mg day-1 , 95%CI 260-330, p<0...
January 17, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29338836/systems-levers-for-commissioning-primary-mental-healthcare-a-rapid-review
#4
Carla Meurk, Meredith Harris, Eryn Wright, Nicola Reavley, Roman Scheurer, Bridget Bassilios, Caroline Salom, Jane Pirkis
Primary Health Networks (PHNs) are a new institution for health systems management in the Australian healthcare system. PHNs will play a key role in mental health reform through planning and commissioning primary mental health services at a regional level, specifically adopting a stepped care approach. Selected PHNs are also trialling a healthcare homes approach. Little is known about the systems levers that could be applied by PHNs to achieve these aims. A rapid review of academic and grey literature published between 2006 and 2016 was undertaken to describe the use of systems levers in commissioning primary care services...
January 17, 2018: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/29338483/reply-to-prehospital-intubation-further-confounders-in-trial-results
#5
Tomas Nuño, Kurt R Denninghoff, Qi Pauls, Sharon D Yeatts, Robert Silbergleit, Yuko Y Palesch, Lisa H Merck, Geoff Manley, David W Wright
No abstract text is available yet for this article.
January 17, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29338330/joint-influence-of-snps-and-dna-methylation-on-lipids-in-african-americans-from-hypertensive-sibships
#6
Michelle L Wright, Erin B Ware, Jennifer A Smith, Sharon L R Kardia, Jacquelyn Y Taylor
INTRODUCTION: Plasma concentrations of lipids (i.e., total cholesterol, high-density cholesterol, low-density cholesterol, and triglycerides) are amenable to therapeutic intervention and remain important factors for assessing risk of cardiovascular diseases. Some of the observed variability in serum lipid concentrations has been associated with genetic and epigenetic variants among cohorts with European ancestry (EA). Serum lipid levels have also been associated with genetic variants in multiethnic populations...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29338313/rapport-building-and-instructional-fading-prior-to-discrete-trial-instruction-moving-from-child-led-play-to-intensive-teaching
#7
M Alice Shillingsburg, Bethany Hansen, Melinda Wright
Discrete trial instruction (DTI) is effective for teaching skills to children with autism spectrum disorder (ASD). Although effective, instructional settings can become aversive resulting in avoidant and escape-related behaviors. Given the significant social impairments associated with ASD, interventions that promote social approach and reduce avoidance are warranted. Rapport building or "pairing" the therapist and teaching setting with highly preferred activities prior to instruction can reduce problematic behaviors during subsequent instruction...
January 1, 2018: Behavior Modification
https://www.readbyqxmd.com/read/29338295/a-scoping-review-of-inclusive-out-of-school-time-physical-activity-programs-for-children-and-youth-with-physical-disabilities
#8
Kelly P Arbour-Nicitopoulos, Viviane Grassmann, Krystn Orr, Amy C McPherson, Guy E Faulkner, F Virginia Wright
The objective of this study was to comprehensively evaluate inclusive out-of-school time physical activity programs for children/youth with physical disabilities. A search of the published literature was conducted and augmented by international expertise. A quality appraisal was conducted; only studies with quality ratings ≥60% informed our best practice recommendations. Seventeen studies were included using qualitative (n = 9), quantitative (n = 5), or mixed (n = 3) designs. Programs had a diversity of age groups, group sizes, and durations...
January 17, 2018: Adapted Physical Activity Quarterly: APAQ
https://www.readbyqxmd.com/read/29337597/hydroxyurea-for-lifelong-transfusion-dependent-%C3%AE-thalassemia-a-meta-analysis
#9
Ali H Algiraigri, Nicola A M Wright, Elizabeth Oddone Paolucci, Aliya Kassam
OBJECTIVE: Chronic blood transfusion remains the most feasible therapeutic option for lifelong transfusion-dependent β-thalassemia (lifelong TDβT). However, it is associated with serious risks and complications. Hydroxyurea (HU), an oral chemotherapeutic drug, is expected to increase hemoglobin levels, thereby minimizing the burden of blood transfusion and its complications. Growing literature over the last twenty years suggests promising results of the use HU in lifelong TDβT; however, its role and safety remain unanswered questions...
January 16, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29337486/improving-risk-stratification-among-veterans-diagnosed-with-prostate-cancer-impact-of-the-17-gene-prostate-score-assay
#10
Julie A Lynch, Megan P Rothney, Raoul R Salup, Cesar E Ercole, Sharad C Mathur, David A Duchene, Joseph W Basler, Javier Hernandez, Michael A Liss, Michael P Porter, Jonathan L Wright, Michael C Risk, Mark Garzotto, Olga Efimova, Laurie Barrett, Brygida Berse, Michael J Kemeter, Phillip G Febbo, Atreya Dash
BACKGROUND: Active surveillance (AS) has been widely implemented within Veterans Affairs' medical centers (VAMCs) as a standard of care for low-risk prostate cancer (PCa). Patient characteristics such as age, race, and Agent Orange (AO) exposure may influence advisability of AS in veterans. The 17-gene assay may improve risk stratification and management selection. OBJECTIVES: To compare management strategies for PCa at 6 VAMCs before and after introduction of the Oncotype DX Genomic Prostate Score (GPS) assay...
January 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29335597/exercise-protects-against-olanzapine-induced-hyperglycemia-in-male-c57bl-6j-mice
#11
Laura N Castellani, Willem T Peppler, Paula M Miotto, Natasha Bush, David C Wright
Olanzapine is a widely prescribed antipsychotic drug. While effective in reducing psychoses, treatment with olanzapine causes rapid increases in blood glucose. We wanted to determine if a single bout of exercise, immediately prior to treatment, would attenuate the olanzapine-induced rise in blood glucose and if this occurred in an IL-6 dependent manner. We found that exhaustive, but not moderate exercise, immediately prior to treatment, prevented olanzapine-induced hyperglycemia and this occurred in parallel with increases in serum IL-6...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335378/comparison-of-telomere-length-measurement-methods
#12
REVIEW
Tsung-Po Lai, Woodring E Wright, Jerry W Shay
The strengths and limitations of the major methods developed to measure telomere lengths (TLs) in cells and tissues are presented in this review. These include Q-PCR (Quantitative Polymerase Chain Reaction), TRF (Terminal Restriction Fragment) analysis, a variety of Q-FISH (Quantitative Fluorescence In Situ Hybridization) methods, STELA (Single TElomere Length Analysis) and TeSLA (Telomere Shortest Length Assay). For each method, we will cover information about validation studies, including reproducibility in independent laboratories, accuracy, reliability and sensitivity for measuring not only the average but also the shortest telomeres...
March 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29335232/smartphone-app-using-mindfulness-meditation-for-women-with-chronic-pelvic-pain-memphis-protocol-for-a-randomized-feasibility-trial
#13
Elizabeth Ball, Sian Newton, Brennan C Kahan, Gordon Forbes, Neil Wright, Clara Cantalapiedra Calvete, Harry A L Gibson, Ewelina Rogozinska, Carol Rivas, Stephanie J C Taylor, Judy Birch, Julie Dodds
BACKGROUND: Female chronic pelvic pain (CPP) is defined as intermittent or constant pelvic or lower abdominal pain occurring in a woman for at least 6 months. Up to a quarter of women are estimated to be affected by CPP worldwide and it is responsible for one fifth of specialist gynecological referrals in the United Kingdom. Psychological interventions are commonly utilized. As waiting times and funding capacity impede access to face-to-face consultations, supported self-management (SSM) has emerged as a viable alternative...
January 15, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29334392/control-of-collagen-gel-mechanical-properties-through-manipulation-of-gelation-conditions-near-the-sol-gel-transition
#14
A J Holder, N Badiei, K Hawkins, C Wright, P R Williams, D J Curtis
The ability to control the mechanical properties of cell culture environments is known to influence cell morphology, motility, invasion and differentiation. The present work shows that it is possible to control the mechanical properties of collagen gels by manipulating gelation conditions near the sol gel transition. This manipulation is accomplished by performing gelation in two stages at different temperatures. The mechanical properties of the gel are found to be strongly dependent on the duration and temperature of the first stage...
January 15, 2018: Soft Matter
https://www.readbyqxmd.com/read/29334379/highly-parallel-direct-rna-sequencing-on-an-array-of-nanopores
#15
Daniel R Garalde, Elizabeth A Snell, Daniel Jachimowicz, Botond Sipos, Joseph H Lloyd, Mark Bruce, Nadia Pantic, Tigist Admassu, Phillip James, Anthony Warland, Michael Jordan, Jonah Ciccone, Sabrina Serra, Jemma Keenan, Samuel Martin, Luke McNeill, E Jayne Wallace, Lakmal Jayasinghe, Chris Wright, Javier Blasco, Stephen Young, Denise Brocklebank, Sissel Juul, James Clarke, Andrew J Heron, Daniel J Turner
Sequencing the RNA in a biological sample can unlock a wealth of information, including the identity of bacteria and viruses, the nuances of alternative splicing or the transcriptional state of organisms. However, current methods have limitations due to short read lengths and reverse transcription or amplification biases. Here we demonstrate nanopore direct RNA-seq, a highly parallel, real-time, single-molecule method that circumvents reverse transcription or amplification steps. This method yields full-length, strand-specific RNA sequences and enables the direct detection of nucleotide analogs in RNA...
January 15, 2018: Nature Methods
https://www.readbyqxmd.com/read/29334044/gene-environment-interplay-in-the-etiology-of-psychosis
#16
Alyson Zwicker, Eileen M Denovan-Wright, Rudolf Uher
Schizophrenia and other types of psychosis incur suffering, high health care costs and loss of human potential, due to the combination of early onset and poor response to treatment. Our ability to prevent or cure psychosis depends on knowledge of causal mechanisms. Molecular genetic studies show that thousands of common and rare variants contribute to the genetic risk for psychosis. Epidemiological studies have identified many environmental factors associated with increased risk of psychosis. However, no single genetic or environmental factor is sufficient to cause psychosis on its own...
January 15, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29331743/preliminary-investigation-of-human-exhaled-breath-for-tuberculosis-diagnosis-by-multidimensional-gas-chromatography-time-of-flight-mass-spectrometry-and-machine-learning
#17
Marco Beccaria, Theodore R Mellors, Jacky S Petion, Christiaan A Rees, Mavra Nasir, Hannah K Systrom, Jean W Sairistil, Marc-Antoine Jean-Juste, Vanessa Rivera, Kerline Lavoile, Patrice Severe, Jean W Pape, Peter F Wright, Jane E Hill
Tuberculosis (TB) remains a global public health malady that claims almost 1.8 million lives annually. Diagnosis of TB represents perhaps one of the most challenging aspects of tuberculosis control. Gold standards for diagnosis of active TB (culture and nucleic acid amplification) are sputum-dependent, however, in up to a third of TB cases, an adequate biological sputum sample is not readily available. The analysis of exhaled breath, as an alternative to sputum-dependent tests, has the potential to provide a simple, fast, and non-invasive, and ready-available diagnostic service that could positively change TB detection...
January 4, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29331659/mindfulness-related-differences-in-neural-response-to-own-infant-negative-versus-positive-emotion-contexts
#18
Heidemarie K Laurent, Dorianne Wright, Megan Finnegan
Mindfulness is thought to promote well-being by shaping the way people respond to challenging social-emotional situations. Current understanding of how this occurs at the neural level is based on studies of response to decontextualized emotion stimuli that may not adequately represent lived experiences. In this study, we tested relations between mothers' dispositional mindfulness and neural responses to their own infant in different emotion-eliciting contexts. Mothers (n = 25) engaged with their 3-month-old infants in videorecorded tasks designed to elicit negative (arm restraint) or positive (peekaboo) emotion...
January 5, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29331404/reliability-and-validity-of-the-adapted-resistance-training-skills-battery-for-children
#19
Bonnie J Furzer, Marc D Bebich-Philip, Kemi E Wright, Siobhan L Reid, Ashleigh L Thornton
OBJECTIVES: Resistance training (RT) is emerging as a training modality to improve motor function and facilitate physical activity participation in children across the motor proficiency spectrum. Although RT competency assessments have been established and validated among adolescent cohorts, the extent to which these methods are suitable for assessing children's RT skills is unknown. This project aimed to assess the psychometric properties of the adapted Resistance Training Skills Battery for Children (RTSBc), in children with varying motor proficiency...
December 29, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29331266/human-papilloma-virus-specific-t-cells-can-be-generated-from-na%C3%A3-ve-t-cells-for-use-as-an-immunotherapeutic-strategy-for-immunocompromised-patients
#20
Sarah E McCormack, Conrad Russell Y Cruz, Kaylor E Wright, Allison B Powell, Haili Lang, Cornelia Trimble, Michael D Keller, Ephraim Fuchs, Catherine M Bollard
Human papilloma virus (HPV) is a known cause of cervical cancer, squamous cell carcinoma and laryngeal cancer. Although treatments exist for HPV-associated malignancies, patients unresponsive to these therapies have a poor prognosis. Recent findings from vaccine studies suggest that T-cell immunity is essential for disease control. Because Epstein-Barr Virus (EBV)-specific T cells have been highly successful in treating or preventing EBV-associated tumors, we hypothesized that the development of a manufacturing platform for HPV-specific T cells from healthy donors could be used in a third-party setting to treat patients with high-risk/relapsed HPV-associated cancers...
January 10, 2018: Cytotherapy
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