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https://www.readbyqxmd.com/read/29684021/laboratory-and-molecular-surveillance-of-paediatric-typhoidal-salmonella-in-nepal-antimicrobial-resistance-and-implications-for-vaccine-policy
#1
Carl D Britto, Zoe A Dyson, Sebastian Duchene, Michael J Carter, Meeru Gurung, Dominic F Kelly, David R Murdoch, Imran Ansari, Stephen Thorson, Shrijana Shrestha, Neelam Adhikari, Gordon Dougan, Kathryn E Holt, Andrew J Pollard
BACKGROUND: Children are substantially affected by enteric fever in most settings with a high burden of the disease, including Nepal. However pathogen population structure and transmission dynamics are poorly delineated in young children, the proposed target group for immunization programs. Here we present whole genome sequencing and antimicrobial susceptibility data on 198 S. Typhi and 66 S. Paratyphi A isolated from children aged 2 months to 15 years of age during blood culture surveillance at Patan Hospital, Nepal, 2008-2016...
April 23, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29683228/relationships-between-self-reported-sleep-quality-components-and-cognitive-functioning-in-breast-cancer-survivors-up-to-10-years-following-chemotherapy
#2
Ashley M Henneghan, Patricia Carter, Alexa Stuifbergan, Brennan Parmelee, Shelli Kesler
OBJECTIVE: Links have been made between aspects of sleep quality and cognitive function in breast cancer survivors (BCS), but findings are heterogeneous. The objective of this study is to examine relationships between specific sleep quality components (latency, duration, efficiency, daytime sleepiness, sleep disturbance, use of sleep aids) and cognitive impairment (performance and perceived), and determine which sleep quality components are the most significant contributors to cognitive impairments in BCS 6 months to 10 years post chemotherapy...
April 23, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29682987/a-community-based-pilot-survey-of-pediatric-food-allergies-in-a-maryland-orthodox-jewish-community
#3
Peter A Kahn, Michelle Trivedi, Amira A Ramadan, William J Sheehan, Carter R Petty, Wanda Phipatanakul
No abstract text is available yet for this article.
April 1, 2018: Clinical Pediatrics
https://www.readbyqxmd.com/read/29682897/an-aseptically-processed-acellular-reticular-allogenic-human-dermis-improves-healing-in-diabetic-foot-ulcers-a-prospective-randomised-controlled-multicentre-follow-up-trial
#4
Charles M Zelen, Dennis P Orgill, Thomas E Serena, Robert E Galiano, Marissa J Carter, Lawrence A DiDomenico, Jennifer Keller, Jarrod P Kaufman, William W Li
Aseptically processed human reticular acellular dermal matrix (HR-ADM) has been previously shown to improve wound closure in 40 diabetic patients with non-healing foot ulcers. The study was extended to 40 additional patients (80 in total) to validate and extend the original findings. The entire cohort of 80 patients underwent appropriate offloading and standard of care (SOC) during a 2-week screening period and, after meeting eligibility criteria, were randomised to receive weekly applications of HR-ADM plus SOC or SOC alone for up to 12 weeks...
April 22, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29681401/capacity-control-and-responsibility-in-parkinson-s-disease-patients-with-impulse-control-disorders-views-of-neurological-and-psychiatric-experts
#5
Andrew Dawson, Jordie Michael, Ella Dilkes-Frayne, Wayne Hall, Nadeeka N Dissanayaka, Adrian Carter
Dopamine replacement therapy can induce impulse control disorders (ICDs) (e.g., hypersexuality) in susceptible Parkinson's disease patients. ICDs can sometimes result in criminal offending. In a number of past Commonwealth cases, it appears offending ICD patients have been considered to be suffering from 'irresistible impulses' such that their decision-making capacity, behavioural control and responsibility were totally compromised. This contrasts with courts' general scepticism of drug-induced 'compulsion' in cases of addiction-related offending...
April 19, 2018: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/29680632/high-intensity-ultrasound-treatment-of-faba-bean-vicia-faba-l-protein-effect-on-surface-properties-foaming-ability-and-structural-changes
#6
Alejandro Martínez-Velasco, Consuelo Lobato-Calleros, Blanca E Hernández-Rodríguez, Angélica Román-Guerrero, Jose Alvarez-Ramirez, E Jaime Vernon-Carter
Response surface methodology was used for establishing the amplitude (72.67%) and time (17.29 min) high-intensity ultrasound (HIUS) conditions leading to an optimized faba bean protein isolate (OFPI) with lower interfacial tension, zeta potential and viscosity, and higher solubility than native faba bean protein isolate (NFPI). OFPI showed significantly higher adsorption dynamics at the air-water interface, and produced foam with significant smaller bubble diameter, higher overrun, stability and yield stress, and lower liquid drainage than NFPI...
June 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29678760/sub-millimeter-ecog-pitch-in-human-enables-higher-fidelity-cognitive-neural-state-estimation
#7
John Hermiz, Nicholas Rogers, Erik Kaestner, Mehran Ganji, Daniel R Cleary, Bob Carter, David Barba, Shadi Dayeh, Eric Halgren, Vikash Gilja
Electrocorticography (ECoG), electrophysiological recording from the pial surface of the brain, is a critical measurement technique for clinical neurophysiology, basic neurophysiology studies, and demonstrates great promise for the development of neural prosthetic devices for assistive applications and the treatment of neurological disorders. Recent advances in device engineering are poised to enable orders of magnitude increase in the resolution of ECoG without comprised measurement quality. This enhancement in cortical sensing enables the observation of neural dynamics from the cortical surface at the micrometer scale...
April 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29677123/catalytic-enantioselective-addition-of-organozirconium-reagents-to-aldehydes
#8
Ricard Solà, Marcos Veguillas, María José González-Soria, Nicholas Carter, M Angeles Fernández-Ibáñez, Beatriz Maciá
A catalytic enantioselective addition reaction of alkylzirconium species to aromatic aldehydes is reported. The reaction, facilitated by a chiral nonracemic diol ligand complex with Ti(O i Pr)₄, proceeds under mild and convenient conditions, and no premade organometallic reagents are required since the alkylzirconium nucleophiles are generated in situ by hydrozirconation of alkenes with the Schwartz reagent. The methodology is compatible with functionalized nucleophiles and a broad range of aromatic aldehydes...
April 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29676945/model-for-predicting-breast-cancer-risk-in-women-with-atypical-hyperplasia
#9
Amy C Degnim, Stacey J Winham, Ryan D Frank, V Shane Pankratz, William D Dupont, Robert A Vierkant, Marlene H Frost, Tanya L Hoskin, Celine M Vachon, Karthik Ghosh, Tina J Hieken, Jodi M Carter, Lori A Denison, Brendan Broderick, Lynn C Hartmann, Daniel W Visscher, Derek C Radisky
Purpose Women with atypical hyperplasia (AH) on breast biopsy have an aggregate increased risk of breast cancer (BC), but existing risk prediction models do not provide accurate individualized estimates of risk in this subset of high-risk women. Here, we used the Mayo benign breast disease cohort to develop and validate a model of BC risk prediction that is specifically for women with AH, which we have designated as AH-BC. Patients and Methods Retrospective cohorts of women age 18 to 85 years with pathologically confirmed benign AH from Rochester, MN, and Nashville, TN, were used for model development and external validation, respectively...
April 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29676732/donated-chemical-probes-for-open-science
#10
Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart Mj Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia Yi Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose...
April 20, 2018: ELife
https://www.readbyqxmd.com/read/29676696/tentorial-sling-for-microvascular-decompression-in-patients-with-trigeminal-neuralgia-a-description-of-operative-technique-and-clinical-outcomes
#11
Jeffrey A Steinberg, Jayson Sack, Bayard Wilson, David Weingarten, Bob Carter, Alexander Khalessi, Sharona Ben-Haim, John Alksne
OBJECTIVE Trigeminal neuralgia is a debilitating pain disorder most often caused by arterial compression of the trigeminal nerve, although there are other etiologies. Microvascular decompression (MVD) remains the most definitive treatment for this disorder, with cure rates reported between 60% and 80%. Traditional MVD techniques involve a retrosigmoid craniotomy with placement of an inert foreign material, such as Teflon, between the nerve and compressive vessel. Recurrence of trigeminal neuralgia after MVD has been associated with vessel migration, adhesion formation, and arterial pulsation against the Teflon abutting the nerve...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676055/the-development-of-funding-recommendations-for-health-technologies-at-the-state-level-a-south-australian-case-study
#12
Robyn Lambert, Drew Carter, Naomi Burgess, Hossein Haji Ali Afzali
OBJECTIVES: State governments often face capped budgets that can restrict expenditure on health technologies and their evaluation, yet many technologies are introduced to practice through state-funded institutions such as hospitals, rather than through national evaluation mechanisms. This research aimed to identify the criteria, evidence, and standards used by South Australian committee members to recommend funding for high-cost health technologies. METHODS: We undertook 8 semi-structured interviews and 2 meeting observations with members of state-wide committees that have a mandate to consider the safety, effectiveness, and cost-effectiveness of high-cost health technologies...
April 20, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29675183/synthesis-and-kinetic-resolution-of-substituted-tetrahydroquinolines-by-lithiation-then-electrophilic-quench
#13
Nicholas Carter, Xiabing Li, Lewis Reavey, Anthony J H M Meijer, Iain Coldham
Treatment of N -Boc-2-aryl-1,2,3,4-tetrahydroquinolines with n -butyllithium in THF at -78 °C resulted in efficient lithiation at the 2-position and the organolithiums were trapped with a variety of electrophiles to give substituted products. Variable temperature NMR spectroscopy gave kinetic data that showed that the rate of tert -butoxycarbonyl (Boc) rotation was fast (Δ G ‡ ≈ 45 kJ mol-1 at -78 °C) and in situ ReactIR spectroscopy showed fast lithiation at -78 °C. By carrying out the lithiation in the presence of the chiral ligand sparteine, kinetic resolutions with very high levels of enantioselectivity were achieved...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674560/complete-genome-sequence-of-a-natural-escherichia-coli-o145-h11-isolate-that-belongs-to-phylogroup-a
#14
Michelle Qiu Carter, Antares Pham
Escherichia coli O145:H11 strain RM14721 was originally isolated from wildlife feces near a leafy greens-growing region in Yuma, AZ. This strain was initially positive for stx 1 ; however, in subsequent cultures, stx 1 was not detected by PCR. Here, we report the complete genome sequence and annotation of RM14721.
April 19, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29674170/theory-of-mind-as-a-link-between-oxytocin-and-maternal-behavior
#15
Anna L MacKinnon, C Sue Carter, Nancy Feeley, Ian Gold, Barbara Hayton, Sangeetha Santhakumaran, Phyllis Zelkowitz
BACKGROUND: Oxytocin is a neuropeptide associated with maternal behavior. However the mechanisms underlying this link remain unclear. In a previous study we observed an indirect effect of increased plasma oxytocin during late pregnancy on early postpartum maternal interactive behavior via theory of mind, as assessed by the Reading the Mind in the Eyes Test (RMET). The current study aimed to extend these findings by testing whether this indirect effect would hold longitudinally for maternal behavior at 2-3 years postpartum, as well as for an additional observational measure of maternal mind-mindedness...
March 27, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29674152/identification-and-functional-analysis-of-the-aspergillic-acid-gene-cluster-in-aspergillus-flavus
#16
Matthew D Lebar, Jeffrey W Cary, Rajtilak Majumdar, Carol H Carter-Wientjes, Brian M Mack, Qijian Wei, Valdet Uka, Sarah De Saeger, José Diana Di Mavungu
Aspergillus flavus can colonize important food staples and produce aflatoxins, a group of toxic and carcinogenic secondary metabolites. Previous in silico analysis of the A. flavus genome revealed 56 gene clusters predicted to be involved in the biosynthesis of secondary metabolites. A. flavus secondary metabolites produced during infection of maize seed are of particular interest, especially with respect to their roles in the biology of the fungus. A predicted nonribosomal peptide synthetase-like (NRPS-like) gene, designated asaC (AFLA_023020), present in the uncharacterized A...
April 16, 2018: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/29673946/subtyping-the-risk-of-intermediate-risk-prostate-cancer-for-active-surveillance-based-on-adverse-pathology-at-radical-prostatectomy
#17
Hiten D Patel, Mohit Gupta, Jeffrey J Tosoian, H Ballentine Carter, Alan W Partin, Jonathan I Epstein
INTRODUCTION: Intermediate-risk (IR) prostate cancer is a heterogenous classification with favorable criteria proposed based on men treated with radiation therapy but uncertain application to active surveillance. We quantified the rate of adverse surgical pathology and implications for survival for patients with favorable IR (FIR) compared to low-risk (LR) prostate cancer. MATERIALS AND METHODS: A comparative cohort study of men with prostate cancer (2009-2013) undergoing radical prostatectomy was conducted in the National Cancer Database...
April 16, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29673798/transcutaneous-co-oximetry-differentiates-asthma-exacerbation-and-convalescence-in-children
#18
David B Kantor, Carter R Petty, Wanda Phipatanakul, Jonathan M Gaffin
This study reports that transcutaneous carboxyhemoglobin (SpCO), measured with a pulse CO-Oximetry device, is a marker of asthma exacerbation in children presenting for emergency care.
April 16, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29672970/should-we-always-honour-parental-requests
#19
EDITORIAL
Brian S Carter
No abstract text is available yet for this article.
April 19, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29671955/smoking-drinking-and-depression-comorbidity-in-head-and-neck-cancer-patients-undergoing-radiotherapy
#20
Kristen McCarter, Amanda L Baker, Benjamin Britton, Luke Wolfenden, Chris Wratten, Judith Bauer, Sean A Halpin, Gregory Carter, Alison K Beck, Lucy Leigh, Christopher Oldmeadow
We aimed to determine the prevalence and co-occurrence of tobacco smoking, alcohol consumption, and depressive symptoms among a sample of head and neck cancer (HNC) patients undergoing radiotherapy. A total of 307 HNC patients participated in a multi-site stepped-wedge randomized controlled trial (RCT) evaluating the effectiveness of a dietitian-delivered health behavior intervention in patients with HNC undergoing radiotherapy. During week one of radiotherapy patients completed measures of smoking, alcohol consumption, and level of depression...
April 19, 2018: Cancer Medicine
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