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https://www.readbyqxmd.com/read/29028974/temporal-dynamics-of-human-frontal-and-cingulate-neural-activity-during-conflict-and-cognitive-control
#1
Eleonora Bartoli, Christopher R Conner, Cihan M Kadipasaoglu, Sudha Yellapantula, Matthew J Rollo, Cameron S Carter, Nitin Tandon
Cognitive control refers to the ability to produce flexible, goal-oriented behavior in the face of changing task demands and conflicting response tendencies. A classic cognitive control experiment is the Stroop-color naming task, which requires participants to name the color in which a word is written while inhibiting the tendency to read the word. By comparing stimuli with conflicting word-color associations to congruent ones, control processes over response tendencies can be isolated. We assessed the spatial specificity and temporal dynamics in the theta and gamma bands for regions engaged in detecting and resolving conflict in a cohort of 13 patients using a combination of high-resolution surface and depth recordings...
September 28, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29027906/directed-assembly-based-printing-of-homogeneous-and-hybrid-nanorods-using-dielectrophoresis
#2
Zhimin Chai, Cihan Yilmaz, Ahmed Busnaina, Charles A Lissandrello, David J D Carter
Printing nano and microscale three-dimensional (3D) structures using directed assembly of nanoparticles has many potential applications in electronics, photonics and biotechnology. This paper presents a reproducible and scalable 3D dielectrophoresis assembly process for printing homogeneous silica and hybrid silica/gold nanorods from silica and gold nanoparticles. The nanoparticles are assembled into patterned vias under a dielectrophoretic force generated by an alternating current (AC) field, and then completely fused in situ to form nanorods...
October 13, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29027235/low-dose-ct-for-the-detection-and-classification-of-metastatic-liver-lesions-results-of-the-2016-low-dose-ct-grand-challenge
#3
Cynthia H McCollough, Adam C Bartley, Rickey E Carter, Baiyu Chen, Tammy A Drees, Phillip Edwards, David R Holmes, Alice E Huang, Farhana Khan, Shuai Leng, Kyle L McMillan, Gregory J Michalak, Kristina M Nunez, Lifeng Yu, Joel G Fletcher
PURPOSE: Using common datasets, to estimate and compare the diagnostic performance of image-based denoising techniques or iterative reconstruction algorithms for the task of detecting hepatic metastases. METHODS: Datasets from contrast-enhanced CT scans of the liver were provided to participants in an NIH-, AAPM- and Mayo Clinic-sponsored Low Dose CT Grand Challenge. Training data included full-dose and quarter-dose scans of the ACR CT accreditation phantom and 10 patient examinations; both images and projections were provided in the training data...
October 2017: Medical Physics
https://www.readbyqxmd.com/read/29026264/more-to-lose-noise-risk-perceptions-of-young-adults-with-hearing-impairment
#4
REVIEW
Lyndal Carter, Deborah Black
This study investigated the attitudes and behaviors of young adults with hearing impairment (HI), in relation to leisure noise. It was hypothesized that young people with HI would have more negative perceptions of noise exposure than their peers with nonimpaired (normal) hearing (NH) and would engage more frequently in self-protective behaviors. Questionnaires were administered as part of a larger study of young Australians with: (1) preadult onset HI and (2) NH. Data from adults (age range 18 to 24 years; n  = 79 with HI, n  = 131 with NH) were selected for the current analysis...
November 2017: Seminars in Hearing
https://www.readbyqxmd.com/read/29023405/the-aspergillus-flavus-homeobox-gene-hbx1-is-required-for-development-and-aflatoxin-production
#5
Jeffrey W Cary, Pamela Harris-Coward, Leslie Scharfenstein, Brian M Mack, Perng-Kuang Chang, Qijian Wei, Matthew Lebar, Carol Carter-Wientjes, Rajtilak Majumdar, Chandrani Mitra, Sourav Banerjee, Anindya Chanda
Homeobox proteins, a class of well conserved transcription factors, regulate the expression of targeted genes, especially those involved in development. In filamentous fungi, homeobox genes are required for normal conidiogenesis and fruiting body formation. In the present study, we identified eight homeobox (hbx) genes in the aflatoxin-producing ascomycete, Aspergillus flavus, and determined their respective role in growth, conidiation and sclerotial production. Disruption of seven of the eight genes had little to no effect on fungal growth and development...
October 12, 2017: Toxins
https://www.readbyqxmd.com/read/29021768/endogenous-oxytocin-vasopressin-and-aggression-in-domestic-dogs
#6
Evan L MacLean, Laurence R Gesquiere, Margaret E Gruen, Barbara L Sherman, W Lance Martin, C Sue Carter
Aggressive behavior in dogs poses public health and animal welfare concerns, however the biological mechanisms regulating dog aggression are not well understood. We investigated the relationships between endogenous plasma oxytocin (OT) and vasopressin (AVP)-neuropeptides that have been linked to affiliative and aggressive behavior in other mammalian species-and aggression in domestic dogs. We first validated enzyme-linked immunosorbent assays (ELISAs) for the measurement of free (unbound) and total (free + bound) OT and AVP in dog plasma...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29021492/optimization-of-the-synthesis-of-structured-phosphatidylcholine-with-medium-chain-fatty-acid
#7
Angélica A Ochoa-Flores, Josafat A Hernández-Becerra, Adriana Cavazos-Garduño, Eduardo J Vernon-Carter, Hugo S García
Structured phosphatidylcholine was successfully produced by acidolysis between phosphatidylcholine and free medium chain fatty acid, using phospholipase A1 immobilized on Duolite A568. Response surface methodology was applied to optimize the reaction system using three process parameters: molar ratio of substrates (phosphatidylcholine to free medium chain fatty acid), enzyme loading, and reaction temperature. All parameters evaluated showed linear and quadratic significant effects on the production of modified phosphatidylcholine; molar ratio of substrates contributed positively, but temperature influenced negatively...
October 11, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/29021129/real-world-treatment-sequences-and-outcomes-among-patients-with-non-small-cell-lung-cancer-resounds-in-the-united-states-study-protocol
#8
Lisa M Hess, David M Kern, Gebra Cuyun Carter, Katherine Winfree, Liya Wang, Angelina Sontag, Ana B Oton
BACKGROUND: Survival outcomes are related to treatment choices in a line of therapy and to treatment sequences across all lines of therapy. OBJECTIVE: The Real-World Treatment Sequences and Outcomes among Patients with NSCLC (RESOUNDS) study is designed to (1) evaluate treatment sequences used for patients who receive at least two lines of therapy for non-small cell lung cancer (NSCLC) in the United States and (2) evaluate patient outcomes in terms of progression-free and overall survival related to treatment sequencing...
October 11, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29019629/health-disparities-and-child-development-after-prematurity
#9
Frances A Carter, Michael E Msall
There is increased recognition that preterm neonates require sequential surveillance to capture the spectrum of coordination, communication, learning, and behavior regulation disorders that may occur in the first 5 years of life and beyond. In particular, the framework of follow-up needs to go beyond the detection of cerebral palsy, blindness, and deafness in the first 2 years of life for only those at highest preterm risk (ie, <28 weeks gestation, with combinations of severe cranial sonographic abnormalities, bronchopulmonary dysplasia, and retinopathy of prematurity)...
October 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/29018956/remote-kinematic-training-for-patients-with-chronic-neck-pain-a-randomised-controlled-trial
#10
Hilla Sarig Bahat, Kate Croft, Courtney Carter, Anna Hoddinott, Elliot Sprecher, Julia Treleaven
PURPOSE: To evaluate short- and intermediate-term effects of kinematic training (KT) using virtual reality (VR) or laser in patients with chronic neck pain. METHODS: A randomised controlled trial with three arms (laser, VR, control) to post-intervention (N = 90), and two arms (laser or VR) continuing to 3 months follow-up. Home training intervention was provided during 4 weeks to VR and laser groups while control group waited. OUTCOME MEASURES: Primary outcome measures included neck disability index (NDI), global perceived effect (GPE), and cervical motion velocity (mean and peak)...
October 10, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28994722/design-modeling-and-synthesis-of-1-2-3-triazole-linked-nucleoside-amino-acid-conjugates-as-potential-antibacterial-agents
#11
Sarah N Malkowski, Carolyn F Dishuck, Gene G Lamanilao, Carter P Embry, Christopher S Grubb, Mauricio Cafiero, Larryn W Peterson
Copper-catalyzed azide-alkyne cycloadditions (CuAAC or click chemistry) are convenient methods to easily couple various pharmacophores or bioactive molecules. A new series of 1,2,3-triazole-linked nucleoside-amino acid conjugates have been designed and synthesized in 57-76% yields using CuAAC. The azido group was introduced on the 5'-position of uridine or the acyclic analogue using the tosyl-azide exchange method and alkylated serine or proparylglycine was the alkyne. Modeling studies of the conjugates in the active site of LpxC indicate they have promise as antibacterial agents...
October 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28994191/transient-behavior-of-the-metal-interface-in-li-metal-garnet-batteries
#12
Kun Fu, Yunhui Gong, Zhezhen Fu, Hua Xie, Yonggang Yao, Boyang Liu, Marcus Carter, Eric Wachsman, Liangbing Hu
The interface between solid electrolytes and Li metal is a primary issue for solid-state batteries. Introducing a metal interlayer to conformally coat solid electrolytes can improve the interface wettability of Li metal and reduce the interfacial resistance, but the mechanism of the metal interlayer is unknown. In this work, we used magnesium (Mg) as a model to investigate the effect of a metal coating on the interfacial resistance of a solid electrolyte and Li metal anode. Our motivation is to understand how the metal interlayer behaves at the interface to promote increased Li-metal wettability of the solid electrolyte surface and reduce interfacial resistance...
October 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28991882/belief-in-treatment-as-prevention-and-its-relationship-to-hiv-status-and-behavioral-risk
#13
Kiffer G Card, Heather L Armstrong, Nathan J Lachowsky, Zishan Cui, Paul Sereda, M Allison Carter, Julio S G Montaner, Robert S Hogg, Eric A Roth, David M Moore
BACKGROUND: We evaluated attitudes towards Treatment as Prevention (TasP) among gay, bisexual, and other men who have sex with men (GBM) in Vancouver, Canada. METHODS: Sexually-active GBM, aged >16, were recruited between 2012-2015 using respondentdriven sampling. At each six-month follow-up, participants completed a computer-administered questionnaire and nursing visit. Repeated measures latent class analysis (RMLCA), grouped by self-reported serostatus, identified patterns of TasP-endorsement by considering TasP-related awareness, attitudes, and behavior...
October 4, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28991540/sex-differences-in-the-risk-of-incident-hypertension-with-sleep-apnea-does-postmenopausal-status-matter
#14
EDITORIAL
Jason R Carter, Babak Mokhlesi
No abstract text is available yet for this article.
October 2017: Chest
https://www.readbyqxmd.com/read/28990415/redox-regulation-of-heme-oxygenase-2-and-the-transcription-factor-rev-erb-through-heme-regulatory-motifs
#15
Angela S Fleischhacker, Eric Carter, Stephen Ragsdale
SIGNIFICANCE: Heme binds to and serves as a cofactor for a myriad of proteins involved in diverse biological processes. Hemoproteins also exhibit varying modes of heme binding, suggesting that protein environment contributes to the functional versatility of this prosthetic group. The subject of this review is a subset of hemoproteins that contain at least one heme regulatory motif (HRM), which is a short sequence containing a Cys-Pro core that in many cases binds heme with the Cys acting as an axial ligand...
October 7, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28988796/nitrogen-dioxide-exposure-in-school-classrooms-of-inner-city-children-with-asthma
#16
Jonathan M Gaffin, Marissa Hauptman, Carter R Petty, William J Sheehan, Peggy S Lai, Jack M Wolfson, Diane R Gold, Brent A Coull, Petros Koutrakis, Wanda Phipatanakul
BACKGROUND: Ambient and home exposure to nitrogen dioxide (NO2) causes asthma symptoms and decreased lung function in children with asthma. Little is known about the health effects of school classroom pollution exposure. OBJECTIVE: We aimed to determine the effect of indoor classroom NO2 on lung function and symptoms of inner-city schoolchildren with asthma. METHODS: Children enrolled in the School Inner City Asthma Study were followed for one academic year...
October 5, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28986987/monte-carlo-simulations-of-a-kilovoltage-external-beam-radiotherapy-system-on-phantoms-and-breast-patients
#17
Dylan Y Breitkreutz, Michael D Weil, Sergei Zavgorodni, Magdalena Bazalova-Carter
PURPOSE: To determine the most suitable lesion size and depth for radiotherapy treatments with a prototype kilovoltage x-ray arc therapy (KVAT) system through Monte Carlo simulations of the dose delivered to lesion, dose homogeneity and lesion-to-skin ratio. METHODS: Monte Carlo simulations were used to calculate dose distributions generated by a novel low-energy kilovoltage x-ray system to a variety of clinically relevant lesion sizes and depths in phantoms and for hypothetical partial breast irradiations of patients in supine and prone positions...
October 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28986656/sustainability-of-statewide-rapid-hiv-testing-in-labor-and-delivery
#18
Lynn M Yee, Emily S Miller, Anne Statton, Laurie D Ayala, Sarah Deardorff Carter, Ann Borders, Amy E Wong, Yolanda Olszewski, Mardge H Cohen, Patricia M Garcia
The objective was to assess sustainability of a statewide program of HIV rapid testing (RT) for pregnant women presenting for delivery with unknown HIV status. This is a population-based retrospective cohort study of women delivered in Illinois hospitals (2012-15). Deidentified data on RT metrics from state-mandated surveillance reports were compared using descriptive statistics and non-parametric tests of trend. Over 95% of the 608,408 women delivered had documented HIV status at presentation. The rate of undocumented HIV status rose from 4...
October 6, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28984717/idiopathic-bilateral-profound-hypotony-in-an-unknown-progressive-neurodegenerative-disorder
#19
Lorraine M Provencher, P Christi Carter, Wallace L M Alward
No abstract text is available yet for this article.
September 3, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28984141/dabrafenib-and-trametinib-in-brafv600e-mutated-glioma
#20
Nicholas F Brown, Thomas Carter, Neil Kitchen, Paul Mulholland
BRAFV600E mutations have been identified in a number of glioma subtypes, most frequently in pleomorphic xanthoastrocytoma, ganglioglioma, pilocytic astrocytoma, and epithelioid glioblastoma. Although the development of BRAF inhibitors has dramatically improved the clinical outcome for patients with BRAFV600E mutant tumors, resistance develops in a majority of patients due to reactivation of the MAPK pathway. Addition of MEK inhibition to BRAF inhibition improves survival. Here we report successful treatment of two patients with BRAFV600E mutant pleomorphic xanthoastrocytoma using the BRAF inhibitor dabrafenib in combination with the MEK inhibitor trametinib...
October 6, 2017: CNS Oncology
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