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https://www.readbyqxmd.com/read/28628636/weight-change-across-the-start-of-three-consecutive-pregnancies-and-the-risk-of-maternal-morbidity-and-sga-birth-at-the-second-and-third-pregnancy
#1
Jacqueline M Wallace, Sohinee Bhattacharya, Graham W Horgan
BACKGROUND: Weight-change across parities and/or current BMI may influence maternal and fetal morbidity and requires to be differentiated to better inform weight-management guidance. METHODS: Direction, pattern and magnitude of weight-change across three consecutive parities and thereby two inter-pregnancy periods was described in 5079 women. The association between inter-pregnancy weight-change versus current BMI and adverse maternal events, SGA-birth and preterm delivery at second and third pregnancy were investigated by logistic regression...
2017: PloS One
https://www.readbyqxmd.com/read/28612643/survey-of-irish-general-practitioners-preferences-for-continuing-professional-development
#2
B Maher, R O'Neill, A Faruqui, C Bergin, M Horgan, D Bennett, C M P O'Tuathaigh
BACKGROUND: Doctors' continuing professional development (CPD) training needs are known to be strongly influenced by national and local contextual characteristics. Given the changing national demographic profile and government-mandated changes to primary care health care provision, this study aimed to investigate Irish General Practitioners' (GPs) perceptions of, and preferences for, current and future CPD programmes. METHODS: A cross-sectional questionnaire, using closed- and open-ended questions, was administered to Irish GPs, focusing on training needs analysis; CPD course content; preferred format and the learning environment...
June 14, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28566220/the-relationship-between-tumour-stage-systemic-inflammation-body-composition-and-survival-in-patients-with-colorectal-cancer
#3
Stephen T McSorley, Douglas H Black, Paul G Horgan, Donald C McMillan
BACKGROUND: Disease progression in cancer is often associated with loss of weight and lean tissue and the development of a systemic inflammatory response (SIR) and these have prognostic value. The present study investigated the relationship between these factors in patients with operable colorectal cancer. METHODS: The study included 322 patients with primary operable colorectal cancer. In addition to BMI, pre-operative CT scans were used to define the presence of visceral obesity, sarcopenia and myosteatosis...
May 19, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28560503/effect-of-increasing-fruit-and-vegetable-intake-by-dietary-intervention-on-nutritional-biomarkers-and-attitudes-to-dietary-change-a-randomised-trial
#4
Susan J Duthie, Garry G Duthie, Wendy R Russell, Janet A M Kyle, Jennie I Macdiarmid, Vanessa Rungapamestry, Sylvia Stephen, Cristina Megias-Baeza, Joanna J Kaniewska, Lindsey Shaw, Lesley Milne, David Bremner, Karen Ross, Philip Morrice, Lynn P Pirie, Graham Horgan, Charles S Bestwick
PURPOSE: Low fruit and vegetable consumption is linked with an increased risk of death from vascular disease and cancer. The benefit of eating fruits and vegetables is attributed in part to antioxidants, vitamins and phytochemicals. Whether increasing intake impacts on markers of disease remains to be established. This study investigates whether increasing daily intake of fruits, vegetables and juices from low (approx. 3 portions), to high intakes (approx. 8 portions) impacts on nutritional and clinical biomarkers...
May 30, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28535834/the-potential-impact-of-compositional-changes-in-farmed-fish-on-its-health-giving-properties-is-it-time-to-reconsider-current-dietary-recommendations
#5
Baukje de Roos, Alan A Sneddon, Matthew Sprague, Graham W Horgan, Ingeborg A Brouwer
Assessment of national dietary guidelines in a number of European countries reveals that some are based on cohort studies, focusing on total seafood consumption, while others are based on the content of EPA and DHA, distinguishing between oily and other fish. The mean actual intake of fish in most countries is around or below the recommended intake, with differences in intake of fish being present between sex and age groups. Many people do not reach the national recommendation for total fish intake. Dietary recommendations for fish and EPA/DHA are based mainly on data collected more than 10 years ago...
May 24, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28518131/incidence-of-respiratory-viral-infection-in-infants-with-respiratory-symptoms-evaluated-for-late-onset-sepsis
#6
J B Cerone, R P Santos, D Tristram, D M Lamson, K A Stellrecht, K St George, M J Horgan, A Rios
OBJECTIVE: To determine the frequency, etiology and impact of respiratory viral infection (RVI) on infants evaluated for late-onset sepsis (LOS), defined as sepsis occurring >72 h of life, in the neonatal intensive care unit. STUDY DESIGN: Prospective observational study conducted from 6 March 2014 to 3 May 2016 on infants evaluated for LOS. PCR viral panel performed on nasopharyngeal specimens among infants with clinical suspicion for RVI. Sequence analysis was performed to determine viral subtypes...
May 18, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28505475/colorectal-cancer-subtypes-translation-to-routine-clinical-pathology
#7
REVIEW
Antonia K Roseweir, Donald C McMillan, Paul G Horgan, Joanne Edwards
Colorectal cancer (CRC) is the second most common cause of cancer death in Europe. Although outcomes have improved, it is clear that from a genomic standpoint CRC is not one disease, but a heterogeneous group of malignancies that arise within one organ. Given that different subtypes have different outcomes, the ability to subtype tumours in the clinic would be highly favourable, enabling optimal treatment for individual patients. In 2015, a consortium proposed four consensus subtypes for CRC (MSI immune, canonical, metabolic, and mesenchymal) based on six classifications systems reported to have prognostic value...
June 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28502248/how-do-private-health-plans-manage-specialty-behavioral-health-treatment-entry-and-continuing-care
#8
Amity E Quinn, Sharon Reif, Elizabeth L Merrick, Constance M Horgan, Deborah W Garnick, Maureen T Stewart
OBJECTIVE: This study examined private health plans' arrangements for accessing and continuing specialty behavioral health treatment in 2010 as federal health reforms were being implemented. These management practices have historically been stricter in behavioral health care than in general medical care; however, the Mental Health Parity and Addiction Equity Act of 2010 required parity in management policies. METHODS: The data source was a nationally representative survey of private health plans' behavioral health treatment management approaches in 2010...
May 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28480074/long-term-responders-to-palliative-chemotherapy-for-advanced-biliary-tract-cancer
#9
Mark K Doherty, Mairéad G McNamara, Priya Aneja, Emma McInerney, Stephanie Moignard, Anne M Horgan, Haiyan Jiang, Tony Panzarella, Raymond Jang, Neesha Dhani, David Hedley, Jennifer J Knox
BACKGROUND: Patients with advanced biliary tract cancer (BTC) are often treated with palliative chemotherapy (PC). Standard PC since 2010 is a cisplatin/gemcitabine doublet, with median overall survival (OS) of 11.7 months from the ABC-02 trial. Prior to this, our institutional standard was gemcitabine and fluoropyrimidine. The ABC-02 study used 8 cycles of PC as standard with treatment stopped even in the absence of disease progression, but some patients may benefit from continuing PC longer than 8 cycles...
April 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28473401/ranolazine-in-symptomatic-diabetic-patients-without-obstructive-coronary-artery-disease-impact-on-microvascular-and-diastolic-function
#10
Nishant R Shah, Michael K Cheezum, Vikas Veeranna, Stephen J Horgan, Viviany R Taqueti, Venkatesh L Murthy, Courtney Foster, Jon Hainer, Karla M Daniels, Jose Rivero, Amil M Shah, Peter H Stone, David A Morrow, Michael L Steigner, Sharmila Dorbala, Ron Blankstein, Marcelo F Di Carli
BACKGROUND: Treatments for patients with myocardial ischemia in the absence of angiographic obstructive coronary artery disease are limited. In these patients, particularly those with diabetes mellitus, diffuse coronary atherosclerosis and microvascular dysfunction is a common phenotype and may be accompanied by diastolic dysfunction. Our primary aim was to determine whether ranolazine would quantitatively improve exercise-stimulated myocardial blood flow and cardiac function in symptomatic diabetic patients without obstructive coronary artery disease...
May 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28443318/peritoneal-tuberculosis-in-the-setting-of-ustekinumab-treatment-for-psoriasis
#11
Maeve Lynch, Lisa Roche, Mary Horgan, Kashif Ahmad, Caitriona Hackett, Bart Ramsay
No abstract text is available yet for this article.
May 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28427085/tumour-invasiveness-the-local-and-systemic-environment-and-the-basis-of-staging-systems-in-colorectal-cancer
#12
J H Park, H van Wyk, C S D Roxburgh, P G Horgan, J Edwards, D C McMillan
BACKGROUND: The present study aimed to examine the relationship between tumour invasiveness (T stage), the local and systemic environment and cancer-specific survival (CSS) of patients with primary operable colorectal cancer. METHODS: The tumour microenvironment was examined using measures of the inflammatory infiltrate (Klintrup-Makinen (KM) grade and Immunoscore), tumour stroma percentage (TSP) and tumour budding. The systemic inflammatory environment was examined using modified Glasgow Prognostic Score (mGPS) and neutrophil:lymphocyte ratio (NLR)...
May 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28423692/the-relationship-between-members-of-the-canonical-nf-%C3%AE%C2%BAb-pathway-components-of-tumour-microenvironment-and-survival-in-patients-with-invasive-ductal-breast-cancer
#13
Lindsay Bennett, Elizabeth A Mallon, Paul G Horgan, Andrew Paul, Donald C McMillan, Joanne Edwards
The aim of the present study was to examine the relationship between tumour NF-κB activation, tumour microenvironment including local inflammatory response (LIR) and cancer-specific survival in patients with operable ductal breast cancer.Immunohistochemistry (tissue microarray of 376 patients) and western blotting (MCF7 and MDA-MB-231 breast cancer cells) was performed to assess expression of key members of the canonical NF-κB pathway (inhibitory kappa B kinase (IKKβ) and phosphorylated p65 Ser-536 (p-p65))...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28401799/book-review-the-psychology-of-terrorism-horgan-j-2014-the-psychology-of-terrorism-2nd-ed-new-york-ny-routledge-184-pp-isbn-978-0-415-69800-9-hbk-isbn-978-0-415-69802-3-pbk-isbn-978-1-315-88224-6-ebk-rrp-usd-54-95
#14
https://www.readbyqxmd.com/read/28383973/psychology-of-terrorism-introduction-to-the-special-issue
#15
John G Horgan
Despite the extraordinary social and political consequences often associated with terrorist violence, as well as our responses to it, psychological research on terrorist behavior is conspicuously underdeveloped. This special issue of American Psychologist presents a series of articles that showcase new conceptual, theoretical, and empirical advances in our understanding of terrorism. In doing so, it seeks to not merely summarize recent accomplishments, but to highlight the immense value of explicitly psychological research on these issues, far more of which is called for to realize the potential for informing solutions...
April 2017: American Psychologist
https://www.readbyqxmd.com/read/28350232/massachusetts-substance-use-disorder-treatment-organizations-perspectives-on-the-affordable-care-act-changes-in-payment-services-and-system-design
#16
Amity E Quinn, Maureen T Stewart, Mary Brolin, Constance M Horgan, Nancy E Lane
The Affordable Care Act (ACA) expanded insurance benefits and coverage for substance use disorder (SUD) treatment and encouraged delivery and payment reforms. Massachusetts passed a similar reform in 2006. This study aims to assess Massachusetts SUD treatment organizations' responses to the ACA. Organizational interviews addressing challenges of and responses to the ACA were conducted in person June-December 2014 with 31 leaders at 12 treatment organizations across Massachusetts. Many organizations were affiliated with medical or social services and offered a range of SUD services...
April 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28350229/commercial-health-plan-coverage-of-selected-treatments-for-opioid-use-disorders-from-2003-to-2014
#17
Sharon Reif, Timothy B Creedon, Constance M Horgan, Maureen T Stewart, Deborah W Garnick
Opioid use disorders (OUDs) are receiving significant attention in the U.S. as a public health crisis. Access to treatment for OUDs is essential and was expected to improve following implementation of the federal parity law and the Affordable Care Act. This study examines changes in coverage and management of treatments for OUDs (opioid treatment programs (OTPs) as a covered service benefit, buprenorphine as a pharmacy benefit) before, during, and after parity and ACA implementation. Data are from three rounds of a nationally representative survey conducted with commercial health plans regarding behavioral health services in benefit years 2003, 2010, and 2014...
April 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28325252/the-role-of-perineural-invasion-in-predicting-survival-in-patients-with-primary-operable-colorectal-cancer-a-systematic-review
#18
REVIEW
H C van Wyk, James Going, Paul Horgan, Donald C McMillan
Perineural invasion is a clear route for cancer cell spread however, the role of nerves in cancer progression is relatively unknown. Recent work would suggest that nerves can actively infiltrate the tumour microenvironment and stimulate cancer cell growth. Therefore, the aim of the present study was to systematically review the identification and associations of perineural invasion and survival in patients with primary operable colorectal cancer. From initial search results of 912 articles, 38 studies were selected...
April 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28251379/the-impact-of-preoperative-dexamethasone-on-the-magnitude-of-the-postoperative-systemic-inflammatory-response-and-complications-following-surgery-for-colorectal-cancer
#19
Stephen T McSorley, Campbell S D Roxburgh, Paul G Horgan, Donald C McMillan
BACKGROUND: The magnitude of the postoperative systemic inflammatory response (SIR), as evidenced by C-reactive protein (CRP), is associated with both short- and long-term outcomes following surgery for colorectal cancer. The present study examined the impact of preoperative dexamethasone on the postoperative SIR and complications following elective surgery for colorectal cancer. METHODS: Patients who underwent elective surgery, with curative intent, for colorectal cancer at a single center between 2008 and 2016 were included (n = 556) in this study...
March 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28207541/examination-of-a-crp-first-approach-for-the-detection-of-postoperative-complications-in-patients-undergoing-surgery-for-colorectal-cancer-a-pragmatic-study
#20
Stephen T McSorley, Bo Y Khor, Graham J MacKay, Paul G Horgan, Donald C McMillan
The aim of the present study was to examine whether a C-reactive protein (CRP) first approach would improve the detection rate of postoperative complications by CT.CRP is a useful biomarker to identify major complications following surgery for colorectal cancer.Patients with histologically confirmed colorectal cancer, who underwent elective surgery between 2008 and 2015 at a single centre were included. Exceeding the established CRP threshold of 150 mg/L on postoperative day (POD) 4 was recorded. Results of CT performed between postoperative days 4 and 14 were recorded...
February 2017: Medicine (Baltimore)
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