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Stephen T McSorley, David Mansouri, Paul G Horgan, Donald C McMillan
No abstract text is available yet for this article.
October 17, 2016: Annals of Surgery
James E East, Jasper L Vleugels, Philip Roelandt, Pradeep Bhandari, Raf Bisschops, Evelien Dekker, Cesare Hassan, Gareth Horgan, Ralf Kiesslich, Gaius Longcroft-Wheaton, Ana Wilson, Jean-Marc Dumonceau
Background and aim: This technical review is an official statement of the European Society of Gastrointestinal Endoscopy (ESGE). It addresses the utilization of advanced endoscopic imaging in gastrointestinal (GI) endoscopy. Methods: This technical review is based on a systematic literature search to evaluate the evidence supporting the use of advanced endoscopic imaging throughout the GI tract. Technologies considered include narrowed-spectrum endoscopy (narrow band imaging [NBI]; flexible spectral imaging color enhancement [FICE]; i-Scan digital contrast [I-SCAN]), autofluorescence imaging (AFI), and confocal laser endomicroscopy (CLE)...
October 6, 2016: Endoscopy
Layan Akijian, Danielle Ní Chróinín, Elizabeth Callaly, Niamh Hannon, Michael Marnane, Áine Merwick, Órla Sheehan, Derek Hayden, Gillian Horgan, Joseph Duggan, Lorraine Kyne, Killian O'Rourke, Sean Murphy, Eamon Dolan, David Williams, Peter J Kelly
BACKGROUND: Few studies have directly compared stroke recurrence rates after stroke and transient ischemic attack, and the risk factors underlying early recurrence are poorly understood. We aimed to investigate risk factors for recurrent stroke after first stroke and transient ischemic attack in a population-based study. METHODS: The North Dublin Population Stroke Study applied multiple overlapping hot and cold pursuit methods, to ascertain hospital- and community-treated stroke and transient ischemic attack patients over a 12-month period...
October 3, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
John Goodwin, Laura Behan, Peter Kelly, Karen McCarthy, Aine Horgan
University students demonstrate poor help-seeking behatabviors for their mental health, despite often reporting low levels of mental well-being. The aims of this study were to examine the help-seeking intentions and experiences of first year university students in terms of their mental well-betabing, and to extaplore these students' views on formal (e.g. psychiatrists) and informal (e.g. friends) help-seeking. Students from a universitytab in the Republic of Ireland (n=220) completed an online questionnaire which focused on mental well-being and help-seeking behaviors...
September 17, 2016: Psychiatry Research
Mary Brolin, Maria Torres, Dominic Hodgkin, Constance Horgan, Margaret Lee, Elizabeth Merrick, Grant Ritter, Lee Panas, Natasha DeMarco, Jonna Hopwood, Andrea Gewirtz, John Straus, Janice Harrington, Nancy Lane
OBJECTIVE: Multiple detoxification admissions among clients with substance use disorders (SUD) are costly to the health care system. This study explored the impact on behavior and cost outcomes of recovery support navigator (RSN) services delivered with and without a contingent incentive intervention. METHODS: New intakes at four detoxification programs were offered RSN-only (N=1116) or RSN plus incentive (RSN+I; N=1551) services. The study used a group-level cross-over design with the intervention in place at each clinic reversed halfway through the enrollment period...
September 12, 2016: Journal of Substance Abuse Treatment
James H Park, Hester C Van Wyk, Donald C McMillan, Jean A Quinn, Dr Jennifer Clark, Campbell Sd Roxburgh, Paul G Horgan, Joanne Edwards
PURPOSE: In patients with colorectal cancer (CRC), a high-density local inflammatory infiltrate response is associated with improved survival, whereas elevated systemic inflammatory responses are associated with poor survival. One potential unifying mechanism is the IL-6/JAK/STAT3 pathway. The present study examines the relationship between tumour total STAT3 and phosphorylated STAT3Tyr705 (pSTAT3) expression, host inflammatory responses and survival in patients undergoing resection of stage I-III CRC...
September 27, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Ruth McCullagh, Christina Dillon, Ann Marie O'Connell, N Frances Horgan, Suzanne Timmons
OBJECTIVES: To measure the step-count accuracy of an ankle-worn accelerometer, a thigh-worn accelerometer and one pedometer in older and frail inpatients. DESIGN: Cross-sectional design study. SETTING: Research room within a hospital. PARTICIPANTS: Convenience sample of inpatients aged ≥65 years, able to walk 20 metres unassisted, with or without a walking-aid. INTERVENTION: Patients completed a 40-minute programme of predetermined tasks while wearing the three motion sensors simultaneously...
September 22, 2016: Archives of Physical Medicine and Rehabilitation
Antonia K Roseweir, Arfon G M T Powell, Lindsay Bennett, Hester C Van Wyk, James Park, Donald C McMillan, Paul G Horgan, Joanne Edwards
In patients with colorectal cancer (CRC), local and systemic inflammatory responses have been extensively reported to associate with cancer survival. However, the specific signalling pathways responsible for inflammatory responses are not clear. The PTEN/Akt pathway is a plausible candidate as it may play a role in mediating inflammation via COX-2, and has been associated with cancer progression. This study therefore examined the relationship between tumour PTEN/Akt/COX-2 expression, inflammatory responses and survival in CRC patients using a tissue microarray...
September 20, 2016: Oncotarget
Hans F Fuchs, Cristina R Harnsberger, Ryan C Broderick, David C Chang, Bryan J Sandler, Garth R Jacobsen, Michael Bouvet, Santiago Horgan
BACKGROUND: The effects of hospital volume on in-hospital mortality after esophageal resection are disputed in the literature. We sought to analyze treatment effects in patient subpopulations that undergo esophagectomy for cancer based on hospital volume. METHODS: We performed a retrospective analysis of the Nationwide Inpatient Sample from 1998 to 2011. Patients who underwent open or laparoscopic transhiatal and transthoracic esophageal resection were identified using ICD-9 codes...
September 22, 2016: Surgical Endoscopy
Aileen Barrett, Rose Galvin, Yvonne Steinert, Albert Scherpbier, Ann O'Shaughnessy, Mary Horgan, Tanya Horsley
INTRODUCTION: The extent to which workplace-based assessment (WBA) can be used as a facilitator of change among trainee doctors has not been established; this is particularly important in the case of underperforming trainees. The aim of this review is to examine the use of WBA in identifying and remediating performance among this cohort. METHODS: Following publication of a review protocol a comprehensive search of eight databases took place to identify relevant articles published prior to November 2015...
September 14, 2016: Medical Teacher
Kasra Razi, Duncan Light, Liam Horgan
Morgagni hernias are a rare form of congenital diaphragmatic hernias, thus there is paucity in literature about the diagnosis and management of the condition. We report an 83-year-old woman who presented with vomiting and a metabolic acidosis with a previous computed tomography diagnosis of Bochdalek's hernia. Diagnostic laparoscopy revealed a Morgagni hernia containing transverse colon, greater curvature of the stomach and a partial gastric volvulus. The hernia was reduced with the sac untouched, and the defect was closed with a composite mesh using tac fixation...
2016: Journal of Surgical Case Reports
Janice E Drew, Andrew J Farquharson, Graham W Horgan, Lynda M Williams
The sirtuin (SIRT)/nicotinamide adenine dinucleotide (NAD) system is implicated in development of type 2 diabetes (T2D) and diet-induced obesity, a major risk factor for T2D. Mechanistic links have not yet been defined. SIRT/NAD system gene expression and NAD/NADH levels were measured in liver, white adipose tissue (WAT) and skeletal muscle from mice fed either a low-fat diet or high-fat diet (HFD) for 3 days up to 16 weeks. An in-house custom-designed multiplex gene expression assay assessed all 7 mouse SIRTs (SIRT1-7) and 16 enzymes involved in conversion of tryptophan, niacin, nicotinamide riboside and metabolic precursors to NAD...
August 14, 2016: Journal of Nutritional Biochemistry
Brendan S Kelly, Ciaran E Redmond, Gregory J Nason, Gerard M Healy, Niall A Horgan, Eric J Heffernan
PURPOSE: Medical journals use social media as a means to disseminate new research and interact with readers. The microblogging site Twitter is one such platform. The aim of this study was to analyze the recent use of Twitter by the leading radiology journals. METHODS: The top 50 journals by Impact Factor were included. Twitter profiles associated with these journals, or their corresponding societies, were identified. Whether each journal used other social media platforms was also recorded...
August 28, 2016: Journal of the American College of Radiology: JACR
Sarah J Lynch, Karina A Horgan, Blanaid White, Dermot Walls
Selenium (Se) is found in inorganic and organic forms, both of which are commonly used in animal feed supplements. The aim of this study was to determine the impact of the chemical form of Se on its associated ameliorative effects on cadmium (Cd)-induced DNA damage in a porcine model. At a cellular level, Cd mediates free oxygen radical production leading in particular to DNA damage, with consequential mutagenesis and inhibition of DNA replication. In this study, porcine jejunal epithelial cells (IPEC-J2) were pre-incubated for 48 h with one of Se-yeast (Sel-Plex), selenomethionine (Se-M), sodium selenite (Se-Ni) or sodium selenate (Se-Na)...
August 26, 2016: Biological Trace Element Research
D Murray, O Hardiman, A Campion, R Vance, F Horgan, D Meldrum
OBJECTIVE: To investigate the effect of an eight-week home-based arm ergometry aerobic exercise programme on physical fitness, fatigue, activity and quality of life in Polio Survivors. DESIGN: An assessor blinded randomised controlled trial. SETTING: Home-based exercise. SUBJECTS: Fifty-five Polio survivors randomised to exercise or control groups. INTERVENTION: Home-based arm ergometry at an intensity of 50%-70% maximum heart rate, compared with usual physiotherapy care...
August 16, 2016: Clinical Rehabilitation
Duncan Light, Kasra Razi, Liam Horgan
INTRODUCTION: Obturator hernias are a rare groin hernia. They are most commonly found incidentally during laparoscopic inguinal hernia repair. We investigated our experience with obturator hernias in the elective and emergency setting. METHODS: Cases of obturator hernia were identified from a hospital database and reviewed retrospectively over the last 10 years. There were no exclusions. There were a number of surgeons involved with an interest in groin hernia surgery...
August 8, 2016: Scottish Medical Journal
Aileen Barrett, Rose Galvin, Albert J J A Scherpbier, Pim W Teunissen, Ann O'Shaughnessy, Mary Horgan
PURPOSE: Workplace-based assessments (WBAs) were originally intended to inform learning and development by structuring effective observation-based feedback. The success of this innovation has not yet been established due in part to the widely varied tools, implementation strategies and research approaches. Using a conceptual framework of experience, trajectories and reifications in workplace learning, we aimed to explore trainer and trainee experiences and perceptions of the learning value of WBAs...
August 2, 2016: Postgraduate Medical Journal
Paul E Terry, Jim Pshock, Michael P O'Donnell, John Cawley, Horgan Karen, Laurie Whitsel, Chris Calitz, Gregg C Fonarow, Paul Terry
No abstract text is available yet for this article.
July 2016: American Journal of Health Promotion: AJHP
Aine Horgan, John Sweeney, Laura Behan, Geraldine Mccarthy
AIM: This study aimed to identify levels of depressive symptoms, social and personal college adjustment and peer support among nursing and midwifery students. BACKGROUND: Student mental health is of international concern, particularly among students who are undertaking professional qualifications in healthcare. DESIGN: Cross-sectional design. METHODS: Data were collected in 2013 using the Centre for Epidemiology Depressive Symptoms Scale, two subscales of the Student Adaptation to College Questionnaire; and a subscale of the Peer Support Evaluation Inventory with 417 students in Ireland...
July 19, 2016: Journal of Advanced Nursing
Pedro Manrique, Zhenfeng Cao, Andrew Gabriel, John Horgan, Paul Gill, Hong Qi, Elvira M Restrepo, Daniela Johnson, Stefan Wuchty, Chaoming Song, Neil Johnson
A popular stereotype is that women will play more minor roles than men as environments become more dangerous and aggressive. Our analysis of new longitudinal data sets from offline and online operational networks [for example, ISIS (Islamic State)] shows that although men dominate numerically, women emerge with superior network connectivity that can benefit the underlying system's robustness and survival. Our observations suggest new female-centric approaches that could be used to affect such networks. They also raise questions about how individual contributions in high-pressure systems are evaluated...
June 2016: Science Advances
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