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Joshu J Mountjoy, Jamie D Howarth, Alan R Orpin, Philip M Barnes, David A Bowden, Ashley A Rowden, Alexandre C G Schimel, Caroline Holden, Huw J Horgan, Scott D Nodder, Jason R Patton, Geoffroy Lamarche, Matthew Gerstenberger, Aaron Micallef, Arne Pallentin, Tim Kane
Although the global flux of sediment and carbon from land to the coastal ocean is well known, the volume of material that reaches the deep ocean-the ultimate sink-and the mechanisms by which it is transferred are poorly documented. Using a globally unique data set of repeat seafloor measurements and samples, we show that the moment magnitude ( M w ) 7.8 November 2016 Kaikōura earthquake (New Zealand) triggered widespread landslides in a submarine canyon, causing a powerful "canyon flushing" event and turbidity current that traveled >680 km along one of the world's longest deep-sea channels...
March 2018: Science Advances
Finbarr G Horgan, Ainara Peñalver Cruz, Carmencita C Bernal, Angelee Fame Ramal, Maria Liberty P Almazan, Andrew Wilby
High resource availability can reduce anti-herbivore resistance (a plant's ability to defend against herbivores and reduce damage) in rice, Oryza sativa L, but may also increase tolerance (a plant's ability to withstand damage by, for example, compensatory growth). Through a series of greenhouse, screenhouse and field experiments, this study examines fitness (survival and development × reproduction) of the brown planthopper, Nilaparvata lugens (Stål), on resistant (IR62) and susceptible (IR22) rice varieties and age-related rice tolerance to planthopper damage under varying resource (nitrogenous fertilizer) availability...
March 2018: Field Crops Research
Benjamin P T Loveday, Jennifer J Knox, Laura A Dawson, Ur Metser, Anthony Brade, Anne M Horgan, Steven Gallinger, Paul D Greig, Carol-Anne Moulton
BACKGROUND AND OBJECTIVES: Neoadjuvant chemoradiation and liver transplantation may be offered for unresectable perihilar cholangiocarcinoma (pCCA). This study aimed to determine the dropout rate and survival of patients who entered a national tri-modality protocol. METHOD: Patients enrolled Jan 2009-Aug 2015 were included. Enrolment criteria: ≤65 years, brush biopsy-proven unresectable pCCA <3.5 cm diameter. Conformal radiotherapy was given concurrently with Capecitabine...
February 2018: Journal of Surgical Oncology
Jason P Block, L Charles Bailey, Matthew W Gillman, Douglas Lunsford, Janne Boone-Heinonen, Lauren P Cleveland, Jonathan Finkelstein, Casie Horgan, Melanie Jay, Juliane S Reynolds, Jessica Sturtevant, Christopher B Forrest
OBJECTIVES: The National Patient-Centered Clinical Research Network (PCORnet) supports observational and clinical research using healthcare data. The PCORnet Antibiotics and Childhood Growth Study is one of PCORnet's inaugural observational studies. The objectives of this manuscript are to describe (1) the processes used to integrate and analyze data from children across 36 participating institutions and (2) the cohort characteristics and prevalence of antibiotic use. METHODS: We included children in the cohort if they had at least one same-day height and weight measured in each of three age periods: 1) before 12 months, 2) 12 to 30 months, and 3) after 24 months...
February 22, 2018: Academic Pediatrics
Aine Horgan, Peter Kelly, John Goodwin, Laura Behan
This study examined the prevalence of depressive symptoms and suicidal ideation among 220 first year undergraduate university students in Ireland. Data were collected using the Centre for Epidemiological Studies Depression Scale and the Suicidal Behaviours Questionnaire. Findings indicated that 59% of participants experienced depressive symptoms and 28.5% had suicidal ideation. Financial stress and poor relationships with both parents, increased the odds of experiencing depressive symptoms. Sexual orientation, financial stress, and poor relationships with fathers, increased the odds of experiencing suicidal ideation...
February 21, 2018: Issues in Mental Health Nursing
Lynda R Corrigan, Dara M Bracken-Clarke, Anne M Horgan
Pancreatic and biliary tract cancers are aggressive malignancies. They commonly present with metastatic or unresectable disease. Those that do present with resectable cancer have high rates of recurrence. Despite recent advances in surgical technique, chemotherapy, and radiotherapy regimens, they are associated with poor survival outcomes. These cancers represent an exception to the trend of improved overall survival evident in most malignancies in recent decades. Depending on the goal of treatment, active management of pancreatic and biliary cancers involves surgery, chemotherapy, and radiation therapy, either alone or in combination...
January 31, 2018: Current Problems in Cancer
Ceres Fernandez-Rozadilla, Christiana Kartsonaki, Connor Woolley, Michael McClellan, Deb Whittington, Gareth Horgan, Simon Leedham, Skirmantas Kriaucionis, James East, Ian Tomlinson
BACKGROUND: Colorectal cancer (CRC) screening might be improved by using a measure of prior risk to modulate screening intensity or the faecal immunochemical test threshold. Intermediate molecular biomarkers could aid risk prediction by capturing both known and unknown risk factors. METHODS: We sampled normal bowel mucosa from the proximal colon, distal colon and rectum of 317 individuals undergoing colonoscopy. We defined cases as having a personal history of colorectal polyp(s)/cancer, and controls as having no history of colorectal neoplasia...
February 13, 2018: British Journal of Cancer
Shanglei Liu, Garth R Jacobsen, Bryan J Sandler, Thomas J Savides, Syed Fehmi, Hans Fuchs, Ran B Luo, Jonathan C Delong, Alisa M Coker, Caitlin Houghton, Santiago Horgan
AIM: Over-the-scope-clip (OTSC) System is a relatively new endoluminal intervention for gastrointestinal (GI) leaks, fistulas, and bleeding. Here, we present a single center experience with the device over the course of 4 years. METHODS: Retrospective chart review was conducted for patients who received endoscopic OTSC treatment. Primary outcome is the resolution of the original indication for clip placement. Secondary outcomes are complications and time to resolution...
February 12, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Aine Horgan, Fionnuala Manning, Julia Bocking, Brenda Happell, Mari Lahti, Rory Doody, Martha Griffin, Stephen K Bradley, Siobhan Russell, Einar Bjornsson, Moira O'Donovan, Liam MacGabhann, Eileen Savage, Jarmo Pulli, John Goodwin, Kornelis Jan van der Vaart, Hazel O'Sullivan, Claire Dorrity, Heikki Ellila, Jerry Allon, Elisabeth Hals, Jan Sitvast, Arild Granerud, Pall Biering
Increasingly, experts as deemed by personal experience or mental health service use, are involved in the education of nurses; however, accompanying research is limited and focuses primarily on opinions of nurse educators and students. The aim of this study was to develop an understanding of the potential contribution to mental health nursing education by those with experience of mental health service use. The research was part of the international COMMUNE (Co-production of Mental Health Nursing Education) project, established to develop and evaluate co-produced mental health content for undergraduate nursing students...
January 29, 2018: International Journal of Mental Health Nursing
Danielle Ní Chróinín, Chantelle Ní Chróinín, Layan Akijian, Elizabeth L Callaly, Niamh Hannon, Lisa Kelly, Michael Marnane, Áine Merwick, Órla Sheehan, Gillian Horgan, Joseph Duggan, Lorraine Kyne, Eamon Dolan, Seán Murphy, David Williams, Peter J Kelly
BACKGROUND: Few population-based studies have assessed lipid adherence to international guidelines for primary and secondary prevention in stroke/transient ischaemic attack (TIA) patients. AIMS: This study aims to evaluate adherence to lipid-lowering therapy (LLT) guidelines amongst patients with ischaemic stroke/TIA. METHODS: Using hot and cold pursuit methods from multiple hospital/community sources, all stroke and TIA cases in North Dublin City were prospectively ascertained over a 1-year period...
January 24, 2018: Irish Journal of Medical Science
Jennifer Cronly, Alistair J Duff, Kristin A Riekert, Ivan J Perry, Anthony P Fitzgerald, Aine Horgan, Elaine Lehane, Barbara Howe, Muireann Ni Chroinin, Eileen Savage
OBJECTIVE: To compare online and paper-based screening for depression and anxiety in adults with cystic fibrosis (CF). DESIGN AND SETTING: Cross-sectional study in CF clinics in Ireland and through the Cystic Fibrosis Ireland online community. PARTICIPANTS: 160 adult patients aged 18 or above were recruited. Of these, 147 were included in the analysis; 83 online and 64 paper-based. The remaining 13 were excluded because of incomplete data...
January 21, 2018: BMJ Open
Erin P Ward, Jian Yang, Jonathan C Delong, Tsai-Wen Sung, James Wang, Chris Barback, Natalie Mendez, Santiago Horgan, William Trogler, Andrew C Kummel, Sarah L Blair
BACKGROUND: Retained foreign bodies (RFOs) have substantial clinical and financial consequences. In laparoscopic surgery, RFOs can be a cause of needing to convert a minimally invasive surgery (MIS) procedure to an open operation. A coating for surgical models was developed to augment localization of needles using fluorescence appropriate for open and minimally invasive surgeries procedures. METHODS: An epoxy matrix containing both dansyl chloride and indocyanine green was coated as visible and near infrared labels, respectively...
January 12, 2018: Surgery
Meera Patel, Stephen T McSorley, James H Park, Campbell S D Roxburgh, Joann Edwards, Paul G Horgan, Donald C McMillan
BACKGROUND: There has been an increasing interest in the role of tumour location in the treatment and prognosis of patients with colorectal cancer (CRC), specifically in the adjuvant setting. Together with genomic data, this has led to the proposal that right-sided and left-sided tumours should be considered as distinct biological and clinical entities. The aim of the present study was to examine the relationship between tumour location, tumour microenvironment, systemic inflammatory response (SIR), adjuvant chemotherapy and survival in patients undergoing potentially curative surgery for stage I-III colon and rectal cancer...
March 6, 2018: British Journal of Cancer
Dominic Hodgkin, Constance M Horgan, Maureen T Stewart, Amity E Quinn, Timothy B Creedon, Sharon Reif, Deborah W Garnick
OBJECTIVE: The 2008 Mental Health Parity and Addiction Equity Act (MHPAEA) sought to improve access to behavioral health care by regulating health plans' coverage and management of services. Health plans have some discretion in how to achieve compliance with MHPAEA, leaving questions about its likely effects on health plan policies. In this study, the authors' objective was to determine how private health plans' coverage and management of behavioral health treatment changed after the federal parity law's full implementation...
January 16, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
Niamh A Merriman, Eithne Sexton, Nora-Ann Donnelly, Grainne McCabe, Mary E Walsh, Daniela Rohde, Ashleigh Gorman, Isabelle Jeffares, Niall Pender, David Williams, Frances Horgan, Frank Doyle, Maev-Ann Wren, Kathleen E Bennett, Anne Hickey
INTRODUCTION: Stroke is one of the primary causes of death and disability worldwide, leaving a considerable proportion of survivors with persistent cognitive and functional deficits. Despite the prevalence of poststroke cognitive impairment, there is no established treatment aimed at improving cognitive function following a stroke. Therefore, the aims of this systematic review are to identify psychological interventions intended to improve poststroke cognitive function and establish their efficacy...
January 10, 2018: BMJ Open
Andrea Acevedo, Margaret T Lee, Deborah W Garnick, Constance M Horgan, Grant A Ritter, Lee Panas, Kevin Campbell, Jason Bean-Mortinson
BACKGROUND: Despite the importance of continuity of care after detoxification and residential treatment, many clients do not receive further treatment services after discharged. This study examined whether offering financial incentives and providing client-specific electronic reminders to treatment agencies lead to improved continuity of care after detoxification or residential treatment. METHODS: Residential (N = 33) and detoxification agencies (N = 12) receiving public funding in Washington State were randomized into receiving one, both, or none (control group) of the interventions...
December 16, 2017: Drug and Alcohol Dependence
Florian J Weise, Varsha Vijay, Andrew P Jacobson, Rebecca F Schoonover, Rosemary J Groom, Jane Horgan, Derek Keeping, Rebecca Klein, Kelly Marnewick, Glyn Maude, Jörg Melzheimer, Gus Mills, Vincent van der Merwe, Esther van der Meer, Rudie J van Vuuren, Bettina Wachter, Stuart L Pimm
Assessing the numbers and distribution of threatened species is a central challenge in conservation, often made difficult because the species of concern are rare and elusive. For some predators, this may be compounded by their being sparsely distributed over large areas. Such is the case with the cheetah Acinonyx jubatus. The IUCN Red List process solicits comments, is democratic, transparent, widely-used, and has recently assessed the species. Here, we present additional methods to that process and provide quantitative approaches that may afford greater detail and a benchmark against which to compare future assessments...
2017: PeerJ
Maureen T Stewart, Constance M Horgan, Dominic Hodgkin, Timothy B Creedon, Amity Quinn, Lindsay Garito, Sharon Reif, Deborah W Garnick
OBJECTIVE: The 2008 federal parity law and the 2010 Affordable Care Act (ACA) sought to expand access to behavioral health services. There was concern that health plans might discourage enrollment by individuals with behavioral health conditions who tend to be higher cost. This study compared behavioral health benefits available in the group insurance market (nonmarketplace) to those sold through the ACA marketplaces to check for evidence of less generous behavioral health coverage in marketplace plans...
December 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
Thomas Horgan, Catherine McNamara, Anthony Ireland, Jonathan Sandy, James Puryer
Calcinosis cutis is a condition of accumulation of calcium salts within the dermis leading to the formation of a calcified mass. This complication has been reported in acne vulgaris and other systemic metabolic disorders. This paper presents a rare case of calcinosis cutis in a 14-year-old male which was found at a routine orthodontic assessment.
2017: Case Reports in Dentistry
Steven D Schwaitzberg, Kurt Roberts, John R Romanelli, David J Desilets, David Earle, Santiago Horgan, Lee Swanstrom, Eric Hungness, Nathaniel Soper, Michael L Kochman
INTRODUCTION: The evolution of Natural Orifice Translumenal Endoscopic Surgery® (NOTES® ) represents a case study in surgical procedural evolution. Beginning in 2004 with preclinical feasibility studies, and followed by the creation of the NOSCAR® collaboration between The Society of American Gastrointestinal and Endoscopic Surgeons and the American Society for Gastrointestinal Endoscopy, procedural development followed a stepwise incremental pathway. The work of this consortium has included white paper analyses, obtaining outside independent funding for basic science and procedural development, and, ultimately, the initiation of a prospective randomized clinical trial comparing NOTES® cholecystectomy as an alternative procedure to laparoscopic cholecystectomy...
December 7, 2017: Surgical Endoscopy
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