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https://www.readbyqxmd.com/read/28717986/thrombolysis-for-stroke-in-ireland-increasing-access-and-maintaining-safety-in-a-challenging-environment
#1
P McElwaine, J McCormack, C Brennan, H Coetzee, P Cotter, R Doyle, A Hickey, F Horgan, C Loughnane, C Macey, P Marsden, D McCabe, R Mulcahy, I Noone, E Shelley, T Stapleton, D Williams, P Kelly, J Harbison
BACKGROUND: In the setting of a national audit of acute stroke services, we examined the delivery of thrombolytic therapy for ischaemic stroke and whether current practice was achieving safe outcomes and consistent delivery for patients. METHOD: Data obtained from the recent national stroke audit was compared against previous Irish audit, the most recent SSNAP UK stroke audit and the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST) study...
July 17, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28702660/poynting-and-reverse-poynting-effects-in-soft-materials
#2
C O Horgan, J G Murphy
In 1909, J. H. Poynting conducted a series of experiments on metal wires and found that loaded wires lengthen when twisted. Thus to maintain a constant length in such experiments, a compressive axial force would need to be applied at the ends of the specimen. This is the classical (positive) Poynting effect. Another example of such an effect arises when a soft material specimen is being axially sheared or rotated between two platens. The necessity to apply a normal force in order to maintain the relative distance between the platens is also often referred to as a Poynting-type effect...
July 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28695389/clinicopathological-determinants-of-an-elevated-systemic-inflammatory-response-following-elective-potentially-curative-resection-for-colorectal-cancer
#3
David G Watt, Michelle L Ramanathan, Stephen T McSorley, Killian Walley, James H Park, Paul G Horgan, Donald C McMillan
INTRODUCTION: The postoperative systemic inflammatory response (SIR) is related to both long- and short-term outcomes following surgery for colorectal cancer. However, it is not clear which clinicopathological factors are associated with the magnitude of the postoperative SIR. The present study was designed to determine the clinicopathological determinants of the postoperative systemic inflammatory response following colorectal cancer resection. METHODS: Patients with a histologically proven diagnosis of colorectal cancer who underwent elective, potentially curative resection during a period from 1999 to 2013 were included in the study (n = 752)...
July 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28693795/the-role-of-the-systemic-inflammatory-response-in-predicting-outcomes-in-patients-with-advanced-inoperable-cancer-systematic-review-and-meta-analysis
#4
REVIEW
Ross D Dolan, Stephen T McSorley, Paul G Horgan, Barry Laird, Donald C McMillan
INTRODUCTION: Cancer remains a leading cause of death worldwide. While a curative intent is the aim of any surgical treatment many patients either present with or go onto develop disseminated disease requiring systemic anti-cancer therapy with a palliative intent. Given their limited life expectancy appropriate allocation of treatment is vital. It is recognised that systemic chemoradiotherapy may shorten the quality/quantity of life in patients with advanced cancer. It is against this background that the present systematic review and meta-analysis of the prognostic value of markers of the systemic inflammatory response in patients with advanced cancer was conducted...
August 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28682133/outcomes-of-an-innovative-training-course-in-laparoscopic-hernia-repair
#5
D Light, S Bawa, P Gallagher, L Horgan
INTRODUCTION The Ethicon™ laparoscopic inguinal groin hernia training (LIGHT) course is an educational course based on three days of teaching on laparoscopic hernia surgery. The first day involves didactic lectures with tutorials. The second day involves practical cadaveric procedures in laparoscopic hernia surgery. The third day involves direct supervision by a consultant surgeon during laparoscopic hernia surgery on a real patient. We reviewed our outcomes for procedures performed on real patients on the final day of the course for early complications and outcomes...
July 6, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28657689/neoadjuvant-chemotherapy-with-mri-monitoring-for-breast-cancer
#6
R V Dave, R Millican-Slater, D Dodwell, K Horgan, N Sharma
BACKGROUND: Neoadjuvant chemotherapy (NACT) is increasingly being offered to patients with breast cancer. No survival benefit has been demonstrated for NACT, but it may serve to reduce tumour size and improve prognosis through the attainment of a pathological complete response (pCR). The role and mode of MRI monitoring during NACT remain unclear. METHODS: Patients managed with NACT at a UK centre over 7 years were studied using a prospectively maintained database, which also included details of MRI...
June 28, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28646242/the-role-of-health-plans-in-supporting-behavioral-health-integration
#7
Maureen T Stewart, Constance M Horgan, Amity E Quinn, Deborah W Garnick, Sharon Reif, Timothy B Creedon, Elizabeth L Merrick
Health plan policies can influence delivery of integrated behavioral health and general medical care. This study provides national estimates for the prevalence of practices used by health plans that may support behavioral health integration. Results indicate that health plans employ financing and other policies likely to support integration. They also directly provide services that facilitate integration. Behavioral health contracting arrangements are associated with use of these policies. Delivery of integrated care requires systemic changes by both providers and payers thus health plans are key players in achieving this goal...
June 23, 2017: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/28643553/renal-dysfunction-and-chronic-kidney-disease-in-ischemic-stroke-and-transient-ischemic-attack-a-population-based-study
#8
Derek Hayden, Christine McCarthy, Layan Akijian, Elizabeth Callaly, Danielle Ní Chróinín, Gillian Horgan, Lorraine Kyne, Joseph Duggan, Eamon Dolan, Killian O' Rourke, David Williams, Sean Murphy, Yvonne O'Meara, Peter J Kelly
Background and purpose The prevalence of chronic kidney disease (estimated glomerular filtration rate (eGFR) <60 mL/min per 1.73 m(2) for ≥3 months, chronic kidney disease (CKD)) in ischemic stroke and transient ischemic attack (TIA) is unknown, as estimates have been based on single-point estimates of renal function. Studies investigating the effect of renal dysfunction (eGFR < 60 mL/min per 1.73 m(2), renal dysfunction) on post-stroke outcomes are limited to hospitalized cohorts and have provided conflicting results...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28643066/solving-the-surgeon-ergonomic-crisis-with-surgical-exosuit
#9
Shanglei Liu, Daniel Hemming, Ran B Luo, Jessica Reynolds, Jonathan C Delong, Bryan J Sandler, Garth R Jacobsen, Santiago Horgan
INTRODUCTION: The widespread adoption of laparoscopic surgery has put new physical demands on the surgeon leading to increased musculoskeletal disorders and injuries. Shoulder, back, and neck pains are among the most common complaints experienced by laparoscopic surgeons. Here, we evaluate the feasibility and efficacy of a non-intrusive progressive arm support exosuit worn by surgeons under the sterile gown to reduce pain and fatigue during surgery. METHODS AND PROCEDURES: This is a prospective randomized crossover study approved by the Internal Review Board (IRB)...
June 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28628636/weight-change-across-the-start-of-three-consecutive-pregnancies-and-the-risk-of-maternal-morbidity-and-sga-birth-at-the-second-and-third-pregnancy
#10
Jacqueline M Wallace, Sohinee Bhattacharya, Graham W Horgan
BACKGROUND: Weight-change across parities and/or current BMI may influence maternal and fetal morbidity and requires to be differentiated to better inform weight-management guidance. METHODS: Direction, pattern and magnitude of weight-change across three consecutive parities and thereby two inter-pregnancy periods was described in 5079 women. The association between inter-pregnancy weight-change versus current BMI and adverse maternal events, SGA-birth and preterm delivery at second and third pregnancy were investigated by logistic regression...
2017: PloS One
https://www.readbyqxmd.com/read/28612643/survey-of-irish-general-practitioners-preferences-for-continuing-professional-development
#11
B Maher, R O'Neill, A Faruqui, C Bergin, M Horgan, D Bennett, C M P O'Tuathaigh
BACKGROUND: Doctors' continuing professional development (CPD) training needs are known to be strongly influenced by national and local contextual characteristics. Given the changing national demographic profile and government-mandated changes to primary care health care provision, this study aimed to investigate Irish General Practitioners' (GPs) perceptions of, and preferences for, current and future CPD programmes. METHODS: A cross-sectional questionnaire, using closed- and open-ended questions, was administered to Irish GPs, focusing on training needs analysis; CPD course content; preferred format and the learning environment...
June 14, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28566220/the-relationship-between-tumour-stage-systemic-inflammation-body-composition-and-survival-in-patients-with-colorectal-cancer
#12
Stephen T McSorley, Douglas H Black, Paul G Horgan, Donald C McMillan
BACKGROUND: Disease progression in cancer is often associated with loss of weight and lean tissue and the development of a systemic inflammatory response (SIR) and these have prognostic value. The present study investigated the relationship between these factors in patients with operable colorectal cancer. METHODS: The study included 322 patients with primary operable colorectal cancer. In addition to BMI, pre-operative CT scans were used to define the presence of visceral obesity, sarcopenia and myosteatosis...
May 19, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28560503/effect-of-increasing-fruit-and-vegetable-intake-by-dietary-intervention-on-nutritional-biomarkers-and-attitudes-to-dietary-change-a-randomised-trial
#13
Susan J Duthie, Garry G Duthie, Wendy R Russell, Janet A M Kyle, Jennie I Macdiarmid, Vanessa Rungapamestry, Sylvia Stephen, Cristina Megias-Baeza, Joanna J Kaniewska, Lindsey Shaw, Lesley Milne, David Bremner, Karen Ross, Philip Morrice, Lynn P Pirie, Graham Horgan, Charles S Bestwick
PURPOSE: Low fruit and vegetable consumption is linked with an increased risk of death from vascular disease and cancer. The benefit of eating fruits and vegetables is attributed in part to antioxidants, vitamins and phytochemicals. Whether increasing intake impacts on markers of disease remains to be established. This study investigates whether increasing daily intake of fruits, vegetables and juices from low (approx. 3 portions), to high intakes (approx. 8 portions) impacts on nutritional and clinical biomarkers...
May 30, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28535834/the-potential-impact-of-compositional-changes-in-farmed-fish-on-its-health-giving-properties-is-it-time-to-reconsider-current-dietary-recommendations
#14
Baukje de Roos, Alan A Sneddon, Matthew Sprague, Graham W Horgan, Ingeborg A Brouwer
Assessment of national dietary guidelines in a number of European countries reveals that some are based on cohort studies, focusing on total seafood consumption, while others are based on the content of EPA and DHA, distinguishing between oily and other fish. The mean actual intake of fish in most countries is around or below the recommended intake, with differences in intake of fish being present between sex and age groups. Many people do not reach the national recommendation for total fish intake. Dietary recommendations for fish and EPA/DHA are based mainly on data collected more than 10 years ago...
May 24, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28518131/incidence-of-respiratory-viral-infection-in-infants-with-respiratory-symptoms-evaluated-for-late-onset-sepsis
#15
J B Cerone, R P Santos, D Tristram, D M Lamson, K A Stellrecht, K St George, M J Horgan, A Rios
OBJECTIVE: To determine the frequency, etiology and impact of respiratory viral infection (RVI) on infants evaluated for late-onset sepsis (LOS), defined as sepsis occurring >72 h of life, in the neonatal intensive care unit. STUDY DESIGN: Prospective observational study conducted from 6 March 2014 to 3 May 2016 on infants evaluated for LOS. PCR viral panel performed on nasopharyngeal specimens among infants with clinical suspicion for RVI. Sequence analysis was performed to determine viral subtypes...
May 18, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28505475/colorectal-cancer-subtypes-translation-to-routine-clinical-pathology
#16
REVIEW
Antonia K Roseweir, Donald C McMillan, Paul G Horgan, Joanne Edwards
Colorectal cancer (CRC) is the second most common cause of cancer death in Europe. Although outcomes have improved, it is clear that from a genomic standpoint CRC is not one disease, but a heterogeneous group of malignancies that arise within one organ. Given that different subtypes have different outcomes, the ability to subtype tumours in the clinic would be highly favourable, enabling optimal treatment for individual patients. In 2015, a consortium proposed four consensus subtypes for CRC (MSI immune, canonical, metabolic, and mesenchymal) based on six classifications systems reported to have prognostic value...
June 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28502248/how-do-private-health-plans-manage-specialty-behavioral-health-treatment-entry-and-continuing-care
#17
Amity E Quinn, Sharon Reif, Elizabeth L Merrick, Constance M Horgan, Deborah W Garnick, Maureen T Stewart
OBJECTIVE: This study examined private health plans' arrangements for accessing and continuing specialty behavioral health treatment in 2010 as federal health reforms were being implemented. These management practices have historically been stricter in behavioral health care than in general medical care; however, the Mental Health Parity and Addiction Equity Act of 2010 required parity in management policies. METHODS: The data source was a nationally representative survey of private health plans' behavioral health treatment management approaches in 2010...
May 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28480074/long-term-responders-to-palliative-chemotherapy-for-advanced-biliary-tract-cancer
#18
Mark K Doherty, Mairéad G McNamara, Priya Aneja, Emma McInerney, Stephanie Moignard, Anne M Horgan, Haiyan Jiang, Tony Panzarella, Raymond Jang, Neesha Dhani, David Hedley, Jennifer J Knox
BACKGROUND: Patients with advanced biliary tract cancer (BTC) are often treated with palliative chemotherapy (PC). Standard PC since 2010 is a cisplatin/gemcitabine doublet, with median overall survival (OS) of 11.7 months from the ABC-02 trial. Prior to this, our institutional standard was gemcitabine and fluoropyrimidine. The ABC-02 study used 8 cycles of PC as standard with treatment stopped even in the absence of disease progression, but some patients may benefit from continuing PC longer than 8 cycles...
April 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28473401/ranolazine-in-symptomatic-diabetic-patients-without-obstructive-coronary-artery-disease-impact-on-microvascular-and-diastolic-function
#19
Nishant R Shah, Michael K Cheezum, Vikas Veeranna, Stephen J Horgan, Viviany R Taqueti, Venkatesh L Murthy, Courtney Foster, Jon Hainer, Karla M Daniels, Jose Rivero, Amil M Shah, Peter H Stone, David A Morrow, Michael L Steigner, Sharmila Dorbala, Ron Blankstein, Marcelo F Di Carli
BACKGROUND: Treatments for patients with myocardial ischemia in the absence of angiographic obstructive coronary artery disease are limited. In these patients, particularly those with diabetes mellitus, diffuse coronary atherosclerosis and microvascular dysfunction is a common phenotype and may be accompanied by diastolic dysfunction. Our primary aim was to determine whether ranolazine would quantitatively improve exercise-stimulated myocardial blood flow and cardiac function in symptomatic diabetic patients without obstructive coronary artery disease...
May 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28443318/peritoneal-tuberculosis-in-the-setting-of-ustekinumab-treatment-for-psoriasis
#20
Maeve Lynch, Lisa Roche, Mary Horgan, Kashif Ahmad, Caitriona Hackett, Bart Ramsay
No abstract text is available yet for this article.
May 2017: JAAD Case Reports
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