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https://www.readbyqxmd.com/read/29326188/managing-cognitive-impairment-following-stroke-protocol-for-a-systematic-review-of-non-randomised-controlled-studies-of-psychological-interventions
#1
Niamh A Merriman, Eithne Sexton, Nora-Ann Donnelly, Grainne McCabe, Mary E Walsh, Daniela Rohde, Ashleigh Gorman, Isabelle Jeffares, Niall Pender, David Williams, Frances Horgan, Frank Doyle, Maev-Ann Wren, Kathleen E Bennett, Anne Hickey
INTRODUCTION: Stroke is one of the primary causes of death and disability worldwide, leaving a considerable proportion of survivors with persistent cognitive and functional deficits. Despite the prevalence of poststroke cognitive impairment, there is no established treatment aimed at improving cognitive function following a stroke. Therefore, the aims of this systematic review are to identify psychological interventions intended to improve poststroke cognitive function and establish their efficacy...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29288914/agency-level-financial-incentives-and-electronic-reminders-to-improve-continuity-of-care-after-discharge-from-residential-treatment-and-detoxification
#2
Andrea Acevedo, Margaret T Lee, Deborah W Garnick, Constance M Horgan, Grant A Ritter, Lee Panas, Kevin Campbell, Jason Bean-Mortinson
BACKGROUND: Despite the importance of continuity of care after detoxification and residential treatment, many clients do not receive further treatment services after discharged. This study examined whether offering financial incentives and providing client-specific electronic reminders to treatment agencies lead to improved continuity of care after detoxification or residential treatment. METHODS: Residential (N = 33) and detoxification agencies (N = 12) receiving public funding in Washington State were randomized into receiving one, both, or none (control group) of the interventions...
December 16, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29250465/the-distribution-and-numbers-of-cheetah-acinonyx-jubatus-in-southern-africa
#3
Florian J Weise, Varsha Vijay, Andrew P Jacobson, Rebecca F Schoonover, Rosemary J Groom, Jane Horgan, Derek Keeping, Rebecca Klein, Kelly Marnewick, Glyn Maude, Jörg Melzheimer, Gus Mills, Vincent van der Merwe, Esther van der Meer, Rudie J van Vuuren, Bettina Wachter, Stuart L Pimm
Assessing the numbers and distribution of threatened species is a central challenge in conservation, often made difficult because the species of concern are rare and elusive. For some predators, this may be compounded by their being sparsely distributed over large areas. Such is the case with the cheetah Acinonyx jubatus. The IUCN Red List process solicits comments, is democratic, transparent, widely-used, and has recently assessed the species. Here, we present additional methods to that process and provide quantitative approaches that may afford greater detail and a benchmark against which to compare future assessments...
2017: PeerJ
https://www.readbyqxmd.com/read/29241429/behavioral-health-coverage-under-the-affordable-care-act-what-can-we-learn-from-marketplace-products
#4
Maureen T Stewart, Constance M Horgan, Dominic Hodgkin, Timothy B Creedon, Amity Quinn, Lindsay Garito, Sharon Reif, Deborah W Garnick
OBJECTIVE: The 2008 federal parity law and the 2010 Affordable Care Act (ACA) sought to expand access to behavioral health services. There was concern that health plans might discourage enrollment by individuals with behavioral health conditions who tend to be higher cost. This study compared behavioral health benefits available in the group insurance market (nonmarketplace) to those sold through the ACA marketplaces to check for evidence of less generous behavioral health coverage in marketplace plans...
December 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29230330/calcifying-acne-an-unusual-extraoral-radiographic-finding
#5
Thomas Horgan, Catherine McNamara, Anthony Ireland, Jonathan Sandy, James Puryer
Calcinosis cutis is a condition of accumulation of calcium salts within the dermis leading to the formation of a calcified mass. This complication has been reported in acne vulgaris and other systemic metabolic disorders. This paper presents a rare case of calcinosis cutis in a 14-year-old male which was found at a routine orthodontic assessment.
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/29218667/the-novel-trial-natural-orifice-versus-laparoscopic-cholecystectomy-a-prospective-randomized-evaluation
#6
Steven D Schwaitzberg, Kurt Roberts, John R Romanelli, David J Desilets, David Earle, Santiago Horgan, Lee Swanstrom, Eric Hungness, Nathaniel Soper, Michael L Kochman
INTRODUCTION: The evolution of Natural Orifice Translumenal Endoscopic Surgery® (NOTES®) represents a case study in surgical procedural evolution. Beginning in 2004 with preclinical feasibility studies, and followed by the creation of the NOSCAR® collaboration between The Society of American Gastrointestinal and Endoscopic Surgeons and the American Society for Gastrointestinal Endoscopy, procedural development followed a stepwise incremental pathway. The work of this consortium has included white paper analyses, obtaining outside independent funding for basic science and procedural development, and, ultimately, the initiation of a prospective randomized clinical trial comparing NOTES® cholecystectomy as an alternative procedure to laparoscopic cholecystectomy...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29218660/how-bariatric-surgery-affects-liver-volume-and-fat-density-in-nafld-patients
#7
Ran B Luo, Toshiaki Suzuki, Jonathan C Hooker, Yesenia Covarrubias, Alexandra Schlein, Shanglei Liu, Jeffrey B Schwimmer, Scott B Reeder, Luke M Funk, Jacob A Greenberg, Guilherme M Campos, Bryan J Sandler, Santiago Horgan, Claude B Sirlin, Garth R Jacobsen
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is an epidemic in the obese population. Bariatric surgery is known to reverse multiple metabolic complications of obesity such as diabetes, dyslipidemia, and NAFLD, but the timing of liver changes has not been well described. MATERIALS AND METHODS: This was an IRB-approved, two-institutional prospective study. Bariatric patients received MRIs at baseline and after a pre-operative liquid diet. Liver biopsies were performed during surgery and if NAFLD positive, the patients received MRIs at 1, 3, and 6 months...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29208590/the-national-patient-centered-clinical-research-network-pcornet-bariatric-study-cohort-rationale-methods-and-baseline-characteristics
#8
Sengwee Toh, Laura J Rasmussen-Torvik, Emily E Harmata, Roy Pardee, Rosalinde Saizan, Elisha Malanga, Jessica L Sturtevant, Casie E Horgan, Jane Anau, Cheri D Janning, Robert D Wellman, R Yates Coley, Andrea J Cook, Anita P Courcoulas, Karen J Coleman, Neely A Williams, Kathleen M McTigue, David Arterburn, James McClay
BACKGROUND: Although bariatric procedures are commonly performed in clinical practice, long-term data on the comparative effectiveness and safety of different procedures on sustained weight loss, comorbidities, and adverse effects are limited, especially in important patient subgroups (eg, individuals with diabetes, older patients, adolescents, and minority patients). OBJECTIVE: The objective of this study was to create a population-based cohort of patients who underwent 3 commonly performed bariatric procedures-adjustable gastric band (AGB), Roux-en-Y gastric bypass (RYGB), and sleeve gastrectomy (SG)-to examine the long-term comparative effectiveness and safety of these procedures in both adults and adolescents...
December 5, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29196718/the-role-of-the-systemic-inflammatory-response-in-predicting-outcomes-in-patients-with-operable-cancer-systematic-review-and-meta-analysis
#9
Ross D Dolan, Jason Lim, Stephen T McSorley, Paul G Horgan, Donald C McMillan
Cancer remains a leading causes of death worldwide and an elevated systemic inflammatory response (SIR) is associated with reduced survival in patients with operable cancer. This review aims to examine the evidence for the role of systemic inflammation based prognostic scores in patients with operable cancers. A wide-ranging literature review using targeted medical subject headings for human studies in English was carried out in the MEDLINE, EMBASE, and CDSR databases until the end of 2016. The SIR has independent prognostic value, across tumour types and geographical locations...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29178362/the-relationship-between-18f-fdg-petct-derived-markers-of-tumour-metabolism-and-systemic-inflammation-in-patients-with-recurrent-disease-following-surgery-for-colorectal-cancer
#10
Stephen T McSorley, Bo Y Khor, Kwong Tsang, David Colville, Sai Han, Paul G Horgan, Donald C McMillan
AIM: 18 F FDG-PETCT derived markers of tumour metabolism have been reported to have prognostic significance in a variety of tumours. Host inflammation is also recognised to have prognostic significance. The aim of the present study was to investigate the relationship between these markers and host systemic inflammation in patients undergoing elective surgery for colorectal cancer. METHODS: Patients with histologically confirmed colorectal cancer, who underwent elective surgery between 2008 and 2015, who also underwent 18 F FDG-PETCT, at a single centre were included (n =103)...
November 25, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29166902/a-national-stakeholder-consensus-study-of-challenges-and-priorities-for-clinical-learning-environments-in-postgraduate-medical-education
#11
Caroline Kilty, Anel Wiese, Colm Bergin, Patrick Flood, Na Fu, Mary Horgan, Agnes Higgins, Bridget Maher, Grainne O'Kane, Lucia Prihodova, Dubhfeasa Slattery, Slavi Stoyanov, Deirdre Bennett
BACKGROUND: High quality clinical learning environments (CLE) are critical to postgraduate medical education (PGME). The understaffed and overcrowded environments in which many residents work present a significant challenge to learning. The purpose of this study was to develop a national expert group consensus amongst stakeholders in PGME to; (i) identify important barriers and facilitators of learning in CLEs and (ii) indicate priority areas for improvement. Our objective was to provide information to focus efforts to provide high quality CLEs...
November 22, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29151691/parallel-mrna-proteomics-and-mirna-expression-analysis-in-cell-line-models-of-the-intestine
#12
Finbarr O'Sullivan, Joanne Keenan, Sinead Aherne, Fiona O'Neill, Colin Clarke, Michael Henry, Paula Meleady, Laura Breen, Niall Barron, Martin Clynes, Karina Horgan, Padraig Doolan, Richard Murphy
AIM: To identify miRNA-regulated proteins differentially expressed between Caco2 and HT-29: two principal cell line models of the intestine. METHODS: Exponentially growing Caco-2 and HT-29 cells were harvested and prepared for mRNA, miRNA and proteomic profiling. mRNA microarray profiling analysis was carried out using the Affymetrix GeneChip Human Gene 1.0 ST array. miRNA microarray profiling analysis was carried out using the Affymetrix Genechip miRNA 3.0 array...
November 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29129358/indocyanine-green-fluorescence-guided-parathyroidectomy-for-primary-hyperparathyroidism
#13
Jonathan C DeLong, Erin P Ward, Thinzar M Lwin, Kevin T Brumund, Kaitlyn J Kelly, Santiago Horgan, Michael Bouvet
BACKGROUND: Our aim was to evaluate the ease and utility of using indocyanine green fluorescence angiography for intraoperative localization of the parathyroid glands. METHODS: Indocyanine green fluorescence angiography was performed during 60 parathyroidectomies for primary hyperparathyroidism during a 22-month period. Indocyanine green was administered intravenously to guide operative navigation using a commercially available fluorescence imaging system. Video files were graded by 3 independent surgeons for strength of enhancement using an adapted numeric scoring system...
November 9, 2017: Surgery
https://www.readbyqxmd.com/read/29128863/persistent-long-term-structural-functional-and-metabolic-changes-after-stress-induced-takotsubo-cardiomyopathy
#14
Caroline Scally, Amelia Rudd, Alice Mezincescu, Heather Wilson, Janaki Srinivasan, Graham Horgan, Paul Broadhurst, David E Newby, Anke Henning, Dana K Dawson
BACKGROUND : Takotsubo cardiomyopathy is an increasingly recognized acute heart failure syndrome precipitated by intense emotional stress. Although there is an apparent rapid and spontaneous recovery of left ventricular ejection fraction, the long-term clinical and functional consequences of takotsubo cardiomyopathy are ill-defined. METHODS : In an observational case-control study, we recruited 37 patients with prior (>12-month) takotsubo cardiomyopathy, and 37 age-, sex-, and comorbidity-matched control subjects...
November 11, 2017: Circulation
https://www.readbyqxmd.com/read/29033002/fiber-orientation-effects-in-simple-shearing-of-fibrous-soft-tissues
#15
Cornelius O Horgan, Jeremiah G Murphy
Fiber-reinforcement is a common feature of many soft biological tissues. Continuum mechanics modeling of the mechanical response of such tissues using transversely isotropic hyperelasticity is now well developed. The fundamental deformation of simple shear within this framework is examined here. It is well known that the normal stress effect characteristic of nonlinear elasticity plays a crucial role in maintaining a homogeneous deformation state in the bulk of the specimen. Here we consider the effect of anisotropy and fiber-orientation on the shear and normal stresses...
September 27, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29021122/influencing-quality-of-outpatient-sud-care-implementation-of-alerts-and-incentives-in-washington-state
#16
Deborah W Garnick, Constance M Horgan, Andrea Acevedo, Margaret T Lee, Lee Panas, Grant A Ritter, Kevin Campbell, Jason Bean-Mortinson
Financial incentives for quality improvement and feedback on specific clients are two approaches to improving the quality of treatment for individuals with substance use disorders. We examined the impacts of these interventions in Washington State by randomizing outpatient substance use treatment agencies into intervention and control groups. From October 2013 through December 2015, agencies could earn financial incentives for meeting performance goals incorporating both achievement relative to a benchmark and improvement from agencies' own baselines...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29021109/design-and-impact-of-bundled-payment-for-detox-and-follow-up-care
#17
Amity E Quinn, Dominic Hodgkin, Jennifer N Perloff, Maureen T Stewart, Mary Brolin, Nancy Lane, Constance M Horgan
INTRODUCTION: Recent payment reforms promote movement from fee-for-service to alternative payment models that shift financial risk from payers to providers, incentivizing providers to manage patients' utilization. Bundled payment, an episode-based fixed payment that includes the prices of a group of services that would typically treat an episode of care, is expanding in the United States. Bundled payment has been recommended as a way to pay for comprehensive SUD treatment and has the potential to improve treatment engagement after detox, which could reduce detox readmissions, improve health outcomes, and reduce medical care costs...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28967380/staging-the-tumor-and-staging-the-host-a-two-centre-two-country-comparison-of-systemic-inflammatory-responses-of-patients-undergoing-resection-of-primary-operable-colorectal-cancer
#18
James H Park, Mitsuru Ishizuka, Stephen T McSorley, Keiichi Kubota, Campbell S D Roxburgh, Hitoshi Nagata, Kazutoshi Takagi, Yoshimi Iwasaki, Taku Aoki, Paul G Horgan, Donald C McMillan
BACKGROUND: How systemic inflammation-based prognostic scores such as the modified Glasgow Prognostic Score (mGPS) and neutrophil:lymphocyte ratio (NLR) differ across populations of patients with colorectal cancer (CRC) remains unknown. The present study examined the mGPS and NLR in patients from United Kingdom (UK) and Japan. METHODS: Patients undergoing resection of TNM I-III CRC in two centres in the UK and Japan were included. Differences in clinicopathological characteristics and mGPS (0-CRP≤10 mg/L, 1-CRP>10 mg/L, 2-CRP>10 mg/L, albumin<35 g/L) and NLR (≤5/>5) were examined...
September 20, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28950730/the-experience-of-recurrent-fallers-in-the-first-year-after-stroke
#19
Mary E Walsh, Rose Galvin, David J P Williams, Joseph A Harbison, Sean Murphy, Ronan Collins, Dominick J H McCabe, Morgan Crowe, N Frances Horgan
PURPOSE: Understanding the experiences of fallers after stroke could inform falls-prevention interventions, which have not yet shown effectiveness in this population. The aim of this study was to explore the experience of recurrent fallers post-stroke in relation to recovery and living with falls. METHODS: Participants who had more than one fall in the first year after stroke were identified from a prospective cohort study. The methods of grounded theory informed data collection and analysis...
September 26, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28940881/diagnostic-yield-of-asymptomatic-arrhythmias-detected-by-mobile-cardiac-outpatient-telemetry-and-autotrigger-looping-event-cardiac-monitors
#20
Wayne M Derkac, Jeffrey R Finkelmeier, Daniel J Horgan, Mathew D Hutchinson
INTRODUCTION: Asymptomatic arrhythmias can have important therapeutic implications in certain patient populations, for example, atrial fibrillation in patients with prior ischemic stroke. We sought to compare the diagnostic yield of two commercially available monitoring systems with automated arrhythmia detection algorithms. METHODS: We queried a large, proprietary database containing rhythm data for patients receiving ambulatory EKG monitoring (BioTelemetry, Malvern, PA, USA)...
September 22, 2017: Journal of Cardiovascular Electrophysiology
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