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https://www.readbyqxmd.com/read/28903011/inter-individual-responses-to-sprint-interval-training-a-pilot-study-investigating-interactions-with-the-sirtuin-system
#1
Stuart R Gray, Tom P Aird, Andrew J Farquharson, Graham W Horgan, Emily Fisher, John Wilson, Gareth E Hopkins, Bradley Anderson, Syed A Ahmad, Stuart R Davis, Janice E Drew
Sprint intensity interval training (SIT) is reported to improve blood glucose control and may be a useful public health tool. The sirtuins and associated genes are emerging as key players in blood glucose control. This study investigated the interplay between the sirtuin/NAD system and individual variation in insulin sensitivity responses after SIT in young healthy individuals. Before and after 4 weeks of SIT body mass and fat percentage were measured and oral glucose tolerance tests (OGTT) performed in 20 young healthy participants (7 females)...
September 13, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28798813/personalising-your-health-an-eu-imperative
#2
EDITORIAL
Denis Horgan
In the fast-moving world of personalised medicine there are many issues and barriers-not least when it comes to getting novel drugs and treatments swiftly to where they are really needed. Slow bench-to-bedside rates do not help the 500 million potential patients across the EU's current 28 Member States, and the timings are affected by several elements during the development and licensing phases. As we all know, personalised medicine starts with the patient. It holds huge potential for improving the health of many patients and ensuring better outcomes for health systems' efficiency and transparency...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28765405/continuing-professional-development-and-irish-hospital-doctors-a-survey-of-current-use-and-future-needs
#3
Bridget Maher, Adnan Faruqui, Mary Horgan, Colm Bergin, Colm O Tuathaigh, Deirdre Bennett
Doctors rate clinical relevance and applicability as the most important determinants of continuing professional development (CPD) course selection. This study examined patterns of current CPD practice and perceived CPD needs among hospital doctors in Ireland across various clinical specialties. A cross-sectional survey was administered to doctors, focusing on the areas of training needs analysis, CPD course content and preferred course format. In total, 547 doctors identified doctor-patient communication as the skill ranked highest for importance and level of current performance...
July 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28761641/attitudes-of-surgeons-to-the-use-of-postoperative-markers-of-the-systemic-inflammatory-response-following-elective-surgery
#4
Ross D Dolan, Stephen T McSorley, Donald C McMillan, Paul G Horgan
BACKGROUND: Cancer is responsible for 7.6 million deaths worldwide and surgery is the primary modality of a curative outcome. Postoperative care is of considerable importance and it is against this backdrop that a questionnaire based study assessing the attitudes of surgeons to monitoring postoperative systemic inflammation was carried out. METHOD: A Web based survey including 10 questions on the "attitudes of surgeons to the use of postoperative markers of the systemic inflammatory response following elective surgery" was distributed via email...
September 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28760511/interarm-blood-pressure-difference-in-a-post-stroke%C3%A2-population
#5
Eva Gaynor, Linda Brewer, Lisa Mellon, Patricia Hall, Frances Horgan, Emer Shelley, Eamonn Dolan, Anne Hickey, Kathleen Bennett, David J Williams
An increased interarm systolic blood pressure (SBP) difference of ≥10 mm Hg is associated with increased cardiovascular risk and a difference of ≥15 mm Hg with increased cerebrovascular risk. The stroke population presents a high-risk group for future cardiovascular and cerebrovascular events and therefore estimation of interarm SBP difference as a predictive tool may assist with further secondary stroke prevention. The aim of the study was to determine the prevalence of interarm SBP and diastolic blood pressure difference in a post-stroke population...
July 4, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28755775/a-systematic-review-of-the-relationship-between-staff-perceptions-of-organizational-readiness-to-change-and-the-process-of-innovation-adoption-in-substance-misuse-treatment-programs
#6
Peter Kelly, Josephine Hegarty, Joe Barry, Kyle R Dyer, Aine Horgan
Translating innovation, such as contemporary research evidence, into policy and practice is a challenge, not just in substance misuse treatment programs, but across all spheres of healthcare. Organizational readiness to change (ORC) has been described as a fundamental concept, and an important determinant of the process of innovation adoption. The aim of this review was to describe the relationship between staff perceptions of ORC and the process of innovation adoption: exposure, adoption, implementation and integration into practice, in substance misuse treatment programs...
September 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28737646/crp-albumin-ratio-an-early-predictor-of-steroid-responsiveness-in-acute-severe-ulcerative-colitis
#7
David J Gibson, Karen Hartery, Jayne Doherty, Jack Nolan, Denise Keegan, Kathryn Byrne, Sean T Martin, Maire Buckley, Juliette Sheridan, Gareth Horgan, Hugh E Mulcahy, Garret Cullen, Glen A Doherty
INTRODUCTION: Identifying hospitalized patients with acute severe ulcerative colitis (ASUC) who will be refractory to corticosteroid therapy and require rescue therapy remains difficult. Hypoalbuminemia worsens with time during hospitalization and is associated with rapid clearance of and reduced response to infliximab (IFX) rescue. Early use of rescue therapy may therefore be more effective. Simple clinical and laboratory predictors of corticosteroid responsiveness would facilitate earlier use of rescue therapy...
July 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28717986/thrombolysis-for-stroke-in-ireland-increasing-access-and-maintaining-safety-in-a-challenging-environment
#8
P McElwaine, J McCormack, C Brennan, H Coetzee, P Cotter, R Doyle, A Hickey, F Horgan, C Loughnane, C Macey, P Marsden, D McCabe, R Mulcahy, I Noone, E Shelley, T Stapleton, D Williams, P Kelly, J Harbison
BACKGROUND: In the setting of a national audit of acute stroke services, we examined the delivery of thrombolytic therapy for ischaemic stroke and whether current practice was achieving safe outcomes and consistent delivery for patients. METHOD: Data obtained from the recent national stroke audit was compared against previous Irish audit, the most recent SSNAP UK stroke audit and the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST) study...
July 17, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28702660/poynting-and-reverse-poynting-effects-in-soft-materials
#9
C O Horgan, J G Murphy
In 1909, J. H. Poynting conducted a series of experiments on metal wires and found that loaded wires lengthen when twisted. Thus to maintain a constant length in such experiments, a compressive axial force would need to be applied at the ends of the specimen. This is the classical (positive) Poynting effect. Another example of such an effect arises when a soft material specimen is being axially sheared or rotated between two platens. The necessity to apply a normal force in order to maintain the relative distance between the platens is also often referred to as a Poynting-type effect...
July 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28695389/clinicopathological-determinants-of-an-elevated-systemic-inflammatory-response-following-elective-potentially-curative-resection-for-colorectal-cancer
#10
David G Watt, Michelle L Ramanathan, Stephen T McSorley, Killian Walley, James H Park, Paul G Horgan, Donald C McMillan
INTRODUCTION: The postoperative systemic inflammatory response (SIR) is related to both long- and short-term outcomes following surgery for colorectal cancer. However, it is not clear which clinicopathological factors are associated with the magnitude of the postoperative SIR. The present study was designed to determine the clinicopathological determinants of the postoperative systemic inflammatory response following colorectal cancer resection. METHODS: Patients with a histologically proven diagnosis of colorectal cancer who underwent elective, potentially curative resection during a period from 1999 to 2013 were included in the study (n = 752)...
September 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28693795/the-role-of-the-systemic-inflammatory-response-in-predicting-outcomes-in-patients-with-advanced-inoperable-cancer-systematic-review-and-meta-analysis
#11
REVIEW
Ross D Dolan, Stephen T McSorley, Paul G Horgan, Barry Laird, Donald C McMillan
INTRODUCTION: Cancer remains a leading cause of death worldwide. While a curative intent is the aim of any surgical treatment many patients either present with or go onto develop disseminated disease requiring systemic anti-cancer therapy with a palliative intent. Given their limited life expectancy appropriate allocation of treatment is vital. It is recognised that systemic chemoradiotherapy may shorten the quality/quantity of life in patients with advanced cancer. It is against this background that the present systematic review and meta-analysis of the prognostic value of markers of the systemic inflammatory response in patients with advanced cancer was conducted...
August 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28682133/outcomes-of-an-innovative-training-course-in-laparoscopic-hernia-repair
#12
D Light, S Bawa, P Gallagher, L Horgan
INTRODUCTION The Ethicon™ laparoscopic inguinal groin hernia training (LIGHT) course is an educational course based on three days of teaching on laparoscopic hernia surgery. The first day involves didactic lectures with tutorials. The second day involves practical cadaveric procedures in laparoscopic hernia surgery. The third day involves direct supervision by a consultant surgeon during laparoscopic hernia surgery on a real patient. We reviewed our outcomes for procedures performed on real patients on the final day of the course for early complications and outcomes...
July 6, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28657689/neoadjuvant-chemotherapy-with-mri-monitoring-for-breast-cancer
#13
R V Dave, R Millican-Slater, D Dodwell, K Horgan, N Sharma
BACKGROUND: Neoadjuvant chemotherapy (NACT) is increasingly being offered to patients with breast cancer. No survival benefit has been demonstrated for NACT, but it may serve to reduce tumour size and improve prognosis through the attainment of a pathological complete response (pCR). The role and mode of MRI monitoring during NACT remain unclear. METHODS: Patients managed with NACT at a UK centre over 7 years were studied using a prospectively maintained database, which also included details of MRI...
August 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28646242/the-role-of-health-plans-in-supporting-behavioral-health-integration
#14
Maureen T Stewart, Constance M Horgan, Amity E Quinn, Deborah W Garnick, Sharon Reif, Timothy B Creedon, Elizabeth L Merrick
Health plan policies can influence delivery of integrated behavioral health and general medical care. This study provides national estimates for the prevalence of practices used by health plans that may support behavioral health integration. Results indicate that health plans employ financing and other policies likely to support integration. They also directly provide services that facilitate integration. Behavioral health contracting arrangements are associated with use of these policies. Delivery of integrated care requires systemic changes by both providers and payers thus health plans are key players in achieving this goal...
June 23, 2017: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/28643553/renal-dysfunction-and-chronic-kidney-disease-in-ischemic-stroke-and-transient-ischemic-attack-a-population-based-study
#15
Derek Hayden, Christine McCarthy, Layan Akijian, Elizabeth Callaly, Danielle Ní Chróinín, Gillian Horgan, Lorraine Kyne, Joseph Duggan, Eamon Dolan, Killian O' Rourke, David Williams, Sean Murphy, Yvonne O'Meara, Peter J Kelly
Background and purpose The prevalence of chronic kidney disease (estimated glomerular filtration rate (eGFR) <60 mL/min per 1.73 m(2) for ≥3 months, chronic kidney disease (CKD)) in ischemic stroke and transient ischemic attack (TIA) is unknown, as estimates have been based on single-point estimates of renal function. Studies investigating the effect of renal dysfunction (eGFR < 60 mL/min per 1.73 m(2), renal dysfunction) on post-stroke outcomes are limited to hospitalized cohorts and have provided conflicting results...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28643066/solving-the-surgeon-ergonomic-crisis-with-surgical-exosuit
#16
Shanglei Liu, Daniel Hemming, Ran B Luo, Jessica Reynolds, Jonathan C Delong, Bryan J Sandler, Garth R Jacobsen, Santiago Horgan
INTRODUCTION: The widespread adoption of laparoscopic surgery has put new physical demands on the surgeon leading to increased musculoskeletal disorders and injuries. Shoulder, back, and neck pains are among the most common complaints experienced by laparoscopic surgeons. Here, we evaluate the feasibility and efficacy of a non-intrusive progressive arm support exosuit worn by surgeons under the sterile gown to reduce pain and fatigue during surgery. METHODS AND PROCEDURES: This is a prospective randomized crossover study approved by the Internal Review Board (IRB)...
June 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28628636/weight-change-across-the-start-of-three-consecutive-pregnancies-and-the-risk-of-maternal-morbidity-and-sga-birth-at-the-second-and-third-pregnancy
#17
Jacqueline M Wallace, Sohinee Bhattacharya, Graham W Horgan
BACKGROUND: Weight-change across parities and/or current BMI may influence maternal and fetal morbidity and requires to be differentiated to better inform weight-management guidance. METHODS: Direction, pattern and magnitude of weight-change across three consecutive parities and thereby two inter-pregnancy periods was described in 5079 women. The association between inter-pregnancy weight-change versus current BMI and adverse maternal events, SGA-birth and preterm delivery at second and third pregnancy were investigated by logistic regression...
2017: PloS One
https://www.readbyqxmd.com/read/28612643/survey-of-irish-general-practitioners-preferences-for-continuing-professional-development
#18
B Maher, R O'Neill, A Faruqui, C Bergin, M Horgan, D Bennett, C M P O'Tuathaigh
BACKGROUND: Doctors' continuing professional development (CPD) training needs are known to be strongly influenced by national and local contextual characteristics. Given the changing national demographic profile and government-mandated changes to primary care health care provision, this study aimed to investigate Irish General Practitioners' (GPs) perceptions of, and preferences for, current and future CPD programmes. METHODS: A cross-sectional questionnaire, using closed- and open-ended questions, was administered to Irish GPs, focusing on training needs analysis; CPD course content; preferred format and the learning environment...
June 14, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28566220/the-relationship-between-tumour-stage-systemic-inflammation-body-composition-and-survival-in-patients-with-colorectal-cancer
#19
Stephen T McSorley, Douglas H Black, Paul G Horgan, Donald C McMillan
BACKGROUND: Disease progression in cancer is often associated with loss of weight and lean tissue and the development of a systemic inflammatory response (SIR) and these have prognostic value. The present study investigated the relationship between these factors in patients with operable colorectal cancer. METHODS: The study included 322 patients with primary operable colorectal cancer. In addition to BMI, pre-operative CT scans were used to define the presence of visceral obesity, sarcopenia and myosteatosis...
May 19, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28560503/effect-of-increasing-fruit-and-vegetable-intake-by-dietary-intervention-on-nutritional-biomarkers-and-attitudes-to-dietary-change-a-randomised-trial
#20
Susan J Duthie, Garry G Duthie, Wendy R Russell, Janet A M Kyle, Jennie I Macdiarmid, Vanessa Rungapamestry, Sylvia Stephen, Cristina Megias-Baeza, Joanna J Kaniewska, Lindsey Shaw, Lesley Milne, David Bremner, Karen Ross, Philip Morrice, Lynn P Pirie, Graham Horgan, Charles S Bestwick
PURPOSE: Low fruit and vegetable consumption is linked with an increased risk of death from vascular disease and cancer. The benefit of eating fruits and vegetables is attributed in part to antioxidants, vitamins and phytochemicals. Whether increasing intake impacts on markers of disease remains to be established. This study investigates whether increasing daily intake of fruits, vegetables and juices from low (approx. 3 portions), to high intakes (approx. 8 portions) impacts on nutritional and clinical biomarkers...
May 30, 2017: European Journal of Nutrition
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