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https://www.readbyqxmd.com/read/29434182/corilagin-attenuates-allergy-and-anaphylactic-reaction-by-inhibiting-degranulation-of-mast-cells
#1
Jie Zhou, Ci'an Zhang, Yuanyuan Sun, Li Wang, Jian Zhang, Fulun Li, Weian Mao
BACKGROUND This study evaluated the anti-allergic activity of corilagin and also postulates the possible mechanism of its action. MATERIAL AND METHODS Corilagin was given orally at dose of 10, 20, and 40 mg/kg/day. All the animals (guinea pigs, rats, and mice) were sensitized for allergy such as eosinophilia and leukocytosis induced by milk; degranulation of mast cell by compound 48/80; and passive and active anaphylaxis. Moreover, the antagonistic effect was determined by estimating the effect of corilagin on contraction of guinea pig tracheal chain and ileum induced by Ach and histamine, respectively...
February 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29431214/human-mast-cells-and-basophils-how-are-they-similar-how-are-they-different
#2
REVIEW
Gilda Varricchi, Ulrike Raap, Felice Rivellese, Gianni Marone, Bernhard F Gibbs
Mast cells and basophils are key contributors to allergies and other inflammatory diseases since they are the most prominent source of histamine as well as numerous additional inflammatory mediators which drive inflammatory responses. However, a closer understanding of their precise roles in allergies and other pathological conditions has been marred by the considerable heterogeneity that these cells display, not only between mast cells and basophils themselves but also across different tissue locations and species...
March 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29427989/diagnosis-and-management-of-severe-asthma
#3
Kian Fan Chung
Severe therapy-resistant asthma has been defined as "asthma which requires treatment with high dose inhaled corticosteroids (ICSs) plus a second controller (and/or systemic corticosteroids) to prevent it from becoming 'uncontrolled' or which remains 'uncontrolled' despite this therapy". Patients who usually present with 'difficult-to-treat asthma' should first be assessed to determine whether he/she has asthma with the exclusion of other diagnoses and if so, whether the asthma can be classified as severe therapy-resistant...
February 2018: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29422859/successful-subcutaneous-allergen-specific-immunotherapy-in-refractory-atopic-keratoconjunctivitis-a-case-report
#4
Passara Jongkhajornpong, Wannada Laisuan
Purpose: We report a case of refractory atopic keratoconjunctivitis (AKC) which was successfully treated with subcutaneous immunotherapy (SCIT). Case Report: A 22-year-old woman presented with severe allergic conjunctivitis for one and a half year. She failed to respond to conventional topical anti-allergic medications, topical corticosteroid, as well as topical cyclosporine A. Therefore, oral corticosteroids had to be prescribed to control the exacerbation for 1 year...
September 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29422822/thyroid-function-and-thyroid-autoantibodies-in-patients-with-chronic-spontaneous-urticaria
#5
Magdalena Czarnecka-Operacz, Anna Sadowska-Przytocka, Dorota Jenerowicz, Anna Szeliga, Zygmunt Adamski, Katarzyna Łącka
Introduction: Chronic urticaria (CU) is a skin disease caused by autoantibodies against high affinity immunoglobulin E (IgE) receptor and against IgE. It is characterized by hives, erythematous wheals and redness present minimum twice a week for at least 6 weeks. It is observed that there is a strong association between CU and autoimmune diseases, such as autoimmune thyroiditis (AT). Aim: To verify the frequency of AT in patients suffering from chronic spontaneous urticaria (CSU) and to confirm the coexistence of CU and AT in the Polish population...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29416543/neutralizing-antibodies-induced-by-gene-based-hydrodynamic-injection-have-a-therapeutic-effect-in-lethal-influenza-infection
#6
Tatsuya Yamazaki, Maria Nagashima, Daisuke Ninomiya, Akira Ainai, Akira Fujimoto, Isao Ichimonji, Hidekazu Takagi, Naoko Morita, Kenta Murotani, Hideki Hasegawa, Joe Chiba, Sachiko Akashi-Takamura
The influenza virus causes annual epidemics and occasional pandemics and is thus a major public health problem. Development of vaccines and antiviral drugs is essential for controlling influenza virus infection. We previously demonstrated the use of vectored immune-prophylaxis against influenza virus infection. We generated a plasmid encoding neutralizing IgG monoclonal antibodies (mAbs) against A/PR/8/34 influenza virus (IAV) hemagglutinin (HA). We then performed electroporation of the plasmid encoding neutralizing mAbs (EP) in mice muscles and succeeded in inducing the expression of neutralizing antibodies in mouse serum...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29413515/baseline-serum-cxcl10-and-il-12-levels-may-predict-severe-asthmatics-responsiveness-to-omalizumab
#7
Maho Suzukawa, Hisako Matsumoto, Nobuharu Ohshima, Hiroyuki Tashimo, Isao Asari, Tomoko Tajiri, Akio Niimi, Hiroyuki Nagase, Hirotoshi Matsui, Nobuyuki Kobayashi, Shunsuke Shoji, Ken Ohta
BACKGROUND: Omalizumab, a humanized anti-IgE monoclonal antibody, is the first molecularly targeted drug for severe asthmatics. However, responses to omalizumab vary widely among patients. OBJECTIVES: This study aimed to assess the potential of baseline serum cytokine levels as predictors of responsiveness to omalizumab. METHODS: Thirty-one patients with severe, persistent asthma were enrolled in this study and administered omalizumab for at least 1 year...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29411552/therapeutic-effect-of-omalizumab-in-severe-asthma-a-real-world-study-in-korea
#8
Ji Ho Lee, Hyun Young Lee, Chang Gyu Jung, Ga Young Ban, Yoo Seob Shin, Young Min Ye, Dong Ho Nahm, Hae Sim Park
PURPOSE: Omalizumab, an anti-immunoglobulin E (IgE) monoclonal antibody, has proved to be effective for the treatment of severe asthma. However, there is no direct evidence of effectiveness of omalizumab in Korean patients with severe asthma. We sought to evaluate the real-world effectiveness of omalizumab in Korean adult patients suffering from severe asthma and to identify predictors of favorable response. METHODS: A retrospective analysis of electrical medical records was performed on severe allergic asthmatic patients with omalizumab treatment group (OT group) for more than 6 months between March 2008 and February 2016...
March 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29409951/benralizumab-efficacy-by-atopy-status-and-serum-immunoglobulin-e-for-patients-with-severe-uncontrolled-asthma
#9
Bradley E Chipps, Paul Newbold, Ian Hirsch, Frank Trudo, Mitchell Goldman
BACKGROUND: Patients with severe asthma can have eosinophilic inflammation and/or allergen sensitization. Benralizumab is an anti-eosinophilic monoclonal antibody being developed for patients with severe, uncontrolled asthma with eosinophilic inflammation. OBJECTIVE: To investigate the efficacy of benralizumab by atopic status and serum immunoglobulin E (IgE) concentrations. METHODS: We analyzed pooled results from the SIROCCO (NCT01928771) and CALIMA (NCT01914757) Phase III studies...
January 31, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29408409/characterization-of-a-hybrid-protein-designed-with-segments-of-allergens-from-blomia-tropicalis-and-dermatophagoides-pteronyssinus
#10
Dalgys Martínez, Jose Fernando Cantillo, Helber Herazo, Judith Wortmann, Walter Keller, Luis Caraballo, Leonardo Puerta L
BACKGROUND: Sensitization to allergens of the house dust mites Dermatophagoides pteronyssinnus and Blomia tropicalis is an important risk factor for asthma and allergic diseases. Allergen-specific immunotherapy is currently based on natural allergen extracts, however, in the last years recombinant allergens with different modifications have shown promising immunological properties that may be advantageously applied for developing novel allergy vaccines. METHODS: A hybrid molecule (MAVAC-BD-2) containing epitopes of B...
February 3, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29403303/the-clinicopathological-features-of-patients-with-membranous-nephropathy
#11
Hanyu Zhu, Qiuxia Han, Dong Zhang, Yong Wang, Jing Gao, Xiaoli Yang, Wenjia Geng, Xiangmei Chen
Background: Membranous nephropathy (MN) represents a distinct glomerular disease which has been considered as a major cause of nephrotic syndrome (NS) in adults. Evidences show that the clinicopathological features of MN are various among MN cases. This study aimed to summarize and analyze the clinicopathological features of patients with MN. Methods: A total of 231 MN patients were recruited in this study. Their clinical and pathological features were collected and analyzed according to their age, gender, pathological stages, and anti-phospholipase A2 receptor (anti-PLA2R) antibodies tests...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29402723/reduction-of-respiratory-infections-in-asthma-patients-supplemented-with-vitamin-d-is-related-to-increased-serum-il-10-and-ifn%C3%AE-levels-and-cathelicidin-expression
#12
E Ramos-Martínez, M R López-Vancell, J C Fernández de Córdova-Aguirre, J Rojas-Serrano, A Chavarría, A Velasco-Medina, G Velázquez-Sámano
BACKGROUND: Vitamin D is a molecule that modulates the immune response and shows anti-inflammatory effects that are beneficial for the control of chronic diseases such as asthma. The trial aim was to explore the effect of vitamin D supplementation on the colonization of pathogenic bacteria in the upper respiratory tract of allergic asthmatic patients. METHODS: This study was conducted in 86 patients between 18 and 50 years of age who were randomly divided into two groups...
February 2, 2018: Cytokine
https://www.readbyqxmd.com/read/29399789/treatment-response-to-omalizumab-in-patients-with-refractory-chronic-spontaneous-urticaria
#13
Nikolaos Syrigos, Dimitra Grapsa, Maria Zande, Marianna Tziotou, Ekaterini Syrigou
BACKGROUND: Previous clinical trials have demonstrated the efficacy and safety of the anti-IgE monoclonal antibody omalizumab in chronic spontaneous urticaria (CSU) not responding to antihistamine treatment. The primary aim of our study was to describe the response patterns of patients with refractory CSU treated with omalizumab in a real-world clinical setting. METHODS: A retrospective analysis of medical records of 20 patients with refractory CSU was performed...
February 5, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29396960/monoclonal-antibodies-for-the-treatment-of-chronic-rhinosinusitis-with-nasal-polyposis-a-systematic-review
#14
N Tsetsos, J K Goudakos, D Daskalakis, I Konstantinidis, K Markou
BACKGROUND: Monoclonal antibodies have been proposed as a novel therapy in patients suffering from chronic rhinosinusitis with nasal polyposis (CRSwNP). The purpose of this systematic review was to evaluate their efficacy and safety. METHODOLOGY: A literature search was performed in MEDLINE, Web of Science, the Cochrane Library and multiple trial registries followed by extensive hand-searching for the identification of relevant studies. Only randomized controlled trials (RCTs) comparing the use of monoclonal antibodies with placebo or another therapy in adult patients with CRSwNP were included...
February 3, 2018: Rhinology
https://www.readbyqxmd.com/read/29388365/collagen-derived-peptides-modulate-cd4-t-cell-differentiation-and-suppress-allergic-responses-in-mice
#15
Akihiko Nishikimi, Yoh-Ichi Koyama, Sayaka Ishihara, Shusaku Kobayashi, Chisa Tometsuka, Masashi Kusubata, Kumiko Kuwaba, Osamu Hayashida, Shunji Hattori, Koko Katagiri
INTRODUCTION: Collagen peptides have been widely used as a food supplement. After ingestion of collagen peptides, oligopeptides containing hydroxyproline (Hyp), which are known to have some physiological activities, are detected in peripheral blood. However, the effects of collagen-peptide administration on immune response are unclear. In the present study, we tested the effects of collagen-peptide ingestion on allergic response and the effects of collagen-derived oligopeptides on CD4+ T-cell differentiation...
February 1, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29386485/juniperus-chinensis-fruits-attenuate-oxazolone-and-2-4-dinitrochlorobenzene-induced-atopic-dermatitis-symptoms-in-mice
#16
Jonghwan Jegal, No-June Park, Sang-A Park, Sim-Kyu Bong, Hyun Jegal, Su-Nam Kim, Min Hye Yang
Juniperus chinensis, commonly Chinese juniper, has been used for treating inflammatory diseases. This study aimed to investigate anti-atopic dermatitis (AD) effects of standardized J. chinensis fruits extract on murine oxazolone- and 2,4-dinitrochlorobenzene (DNCB)-induced models of AD. Ear swelling, epidermis thickening, and eosinophils infiltration in the oxazolone-mediated dermatitis of BALB/c mice were significantly reduced upon topical application of J. chinensis fruits 95% EtOH extract (JCE). Besides, transdermal administration of JCE to SKH-1 hairless mice inhibited the development of DNCB-induced AD-like skin lesions by suppressing transepidermal water loss and improving skin hydration...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29381818/role-of-omalizumab-in-insulin-hypersensitivity-a-case-report-and-review-of-the-literature
#17
S Mishra, L Connors, B Tugwell
BACKGROUND: Insulin allergy is a rare yet severe side effect of exogenous insulin use. Management typically involves use of alternative antihyperglycaemic agents, symptom control with antihistamines, use of different insulin formulations, and induction of tolerance with incremental doses of insulin. This treatment regimen is not always successful, and the use of omalizumab, an anti-IgE monoclonal antibody, has been used to induce tolerance to insulin. CASE REPORT: G...
January 30, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29372536/biological-therapies-for-eosinophilic-esophagitis-where-do-we-stand
#18
REVIEW
Emily Ko, Mirna Chehade
Eosinophilic esophagitis (EoE) is an immune-mediated, chronic esophageal disease characterized by esophageal symptoms and esophageal eosinophilia. It is triggered by foods and possibly by environmental allergens. Currently, there are no FDA-approved therapies for EoE. Commonly used treatments include dietary restrictions and topical corticosteroids. Many of these therapies are suboptimal in their efficacy, have side effects, or diminish patients' quality of life. Biologic therapies for EoE have therefore been sought as an alternative...
January 25, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29363753/activated-leukocyte-cell-adhesion-molecule-alcam-cd166-regulates-t-cell-responses-in-a-murine-model-of-food-allergy
#19
Yun Seon Kim, Mi Na Kim, Kyung Eun Lee, Jung Yeon Hong, Mi Seon Oh, Soo Yeon Kim, Kyung Won Kim, Myung Hyun Sohn
Food allergy is a major public health problem. Studies have shown that long-term interactions between activated leukocyte cell adhesion molecule (ALCAM/CD166), on the surface of antigen presenting cells, and CD6, a co-stimulatory molecule, influence immune responses. However, there are currently no studies on the functions of ALCAM in food allergy. Therefore, we aimed to identify the functions of ALCAM in ovalbumin (OVA)-induced food allergy using ALCAM-deficient mice. Wild-type (WT) and ALCAM-deficient (ALCAM-/- ) mice were intraperitoneally sensitized with and orally fed OVA...
January 24, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29360526/short-term-ibrutinib-therapy-suppresses-skin-test-responses-and-eliminates-ige-mediated-basophil-activation-in-adults-with-peanut-or-tree-nut-allergy
#20
Melanie C Dispenza, Jacqueline A Pongracic, Anne Marie Singh, Bruce S Bochner
Two doses of ibrutinib significantly reduced skin prick test area and anti-IgE-induced basophil activation responses in peanut and tree nut allergic adults. Ibrutinib or other BTK inhibitors could potentially be used to prevent anaphylaxis.
January 19, 2018: Journal of Allergy and Clinical Immunology
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