keyword
MENU ▼
Read by QxMD icon Read
search

Anti IgE

keyword
https://www.readbyqxmd.com/read/29672862/aryl-hydrocarbon-receptor-activation-by-diesel-exhaust-particles-mediates-epithelium-derived-cytokines-expression-in-severe-allergic-asthma
#1
Chih-Ming Weng, Chun-Hua Wang, Meng-Jung Lee, Jung-Re He, Hsin-Yu Huang, Ming-Wei Chao, Kian Fan Chung, Han-Pin Kuo
BACKGROUND: Exposure to environmental pollutants promotes Th2 cell responses. Aryl hydrocarbon receptor (AhR) activation aggravates allergic responses. Epithelium-derived thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33 are implicated in the dysregulation of Th2 immune responses in severe allergic asthma. METHODS: Bronchial biopsies of 28 allergic severe asthma and 6 mild asthma subjects from highly polluted areas were analyzed for AhR nuclear translocation (NT), cytokine expression and gene activation...
April 19, 2018: Allergy
https://www.readbyqxmd.com/read/29668337/reduced-longitudinal-cardiac-strain-in-asthma-patients
#2
I Tuleta, N Eckstein, F Aurich, G Nickenig, C Schaefer, D Skowasch, R Schueler
OBJECTIVE: There is limited knowledge about the potential relationship between asthma and heart function. Aim of our present study was to examine if asthma may be associated with manifest or subclinical heart dysfunction. METHODS: 72 allergic mild-to-moderate and severe asthma patients and 20 matched controls were enrolled in the study. Depending on the anti-asthmatic therapy, four subgroups of asthma patients were created: patients under long-acting beta2-agonists (LABA) and inhaled cortisone without oral cortisone treatment with (1a) versus without (1b) additional omalizumab therapy; patients with LABA, inhaled cortisone and omalizumab treatment with (2a) versus without (2b) oral cortisone...
April 18, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29662320/omalizumab-for-severe-asthma-toward-personalized-treatment-based-on-biomarker-profile-and-clinical-history
#3
REVIEW
Farnaz Tabatabaian, Dennis K Ledford
Asthma is a heterogeneous syndrome with numerous underlining molecular and inflammatory mechanisms contributing to the wide spectrum of clinical phenotypes. Multiple therapies targeting severe asthma with type 2 (T2) high inflammation are or soon will be available. T2 high inflammation is defined as inflammation associated with atopy or eosinophilia or an increase in cytokines associated with T-helper 2 lymphocytes. Omalizumab is a humanized anti-IgE monoclonal antibody and the first biologic therapy approved for moderate-severe allergic asthma...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29660465/jageum-jung-improves-2-4-dinitrochlorobenzene-induced-atopic-dermatitis-like-skin-lesions-in-mice-and-suppresses-pro-inflammatory-chemokine-production-by-inhibiting-tnf-%C3%AE-ifn-%C3%AE-induced-stat-1-and-nf%C3%AE%C2%BAb-signaling-in-hacat-cells
#4
Ju-Hye Yang, Hyun Ju Do, Esther Lee, Nam-Hui Yim, Won-Kyung Cho, Kwang-Il Park, Jin Yeul Ma
ETHNOPHARMACOLOGICAL RELEVANCE: Jageum-Jung (JGJ) is an oriental herbal formula comprising five herbs (Melaphis chinensis Bell, Cremastra variabilis Nakai, Knoxia valerianoides Thorel, Euphorbia lathyris L., and Moschus moschiferus L.). It has been used for detoxification and treating cancer and inflammatory diseases in China, Japan, and Korea. However, the mechanism of action of JGJ on keratinocyte inflammatory response is poorly understood. AIM OF THE STUDY: In the present study, we investigated the anti-inflammatory mechanism of JGJ and studied the effects of JGJ on atopic dermatitis-like skin lesions in mice...
April 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29660428/the-kinetics-of-anti-drug-antibodies-drug-levels-and-clinical-outcomes-in-infliximab-exposed-patients-with-immuno-mediated-disorders
#5
Nencini Francesca, Vultaggio Alessandra, Pratesi Sara, Cammelli Daniele, Milla Monica, Fiori Ginevra, Bagnoli Siro, Prignano Francesca, Romagnani Sergio, Maggi Enrico, Matucci Andrea
BACKGROUND: Hypersensitivity reactions (HRs) and loss of response (LOR) to infliximab (IFX) are related to drug immunogenicity characterized by anti-drug antibodies (ADA). OBJECTIVE: To analyse the timing of ADA appearance, and its relationship with drug levels and clinical outcomes in IFX-treated patients with different diseases. METHODS: Samples were longitudinally collected before each infusion from 91 IFX-treated patients and were assayed for ADA and drug levels by ELISA and for IgE by CAP-system Clinical data were also monitored, regarding efficacy and safety of therapy...
April 13, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29653408/a-new-flavonoid-from-stellera-chamaejasme-l-stechamone-alleviated-2-4-dinitrochlorobenzene-induced-atopic-dermatitis-like-skin-lesions-in-a-murine-model
#6
Beom-Geun Jo, No-June Park, Jonghwan Jegal, Sangho Choi, Sang Woo Lee, Hang Jin, Su-Nam Kim, Min Hye Yang
Stellera chamaejasme L. (family Thymelaeaceae), also known as 'Langdu', has been traditionally used to treat of skin-related diseases, such as, psoriasis and skin ulcers. The aim of this study was to identify the biologically active component of S. chamaejasme and evaluate its preventive effects on IL-4 and mast cell degranulation in RBL-2H3 cells and on the development of atopic dermatitis (AD) in 2,4-dinitrochlorobenzene (DNCB)-treated SKH-1 hairless mice. A novel flavonoid, genkwanin 5-O-xylosyl(1 → 2)glucoside (named stechamone), and three known compounds (umbelliferone, luteolin, and luteolin-7-O-glucoside) were isolated from the aerial parts of S...
April 10, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29649507/effects-of-anthraquinones-from-cassia-occidentalis-l-on-ovalbumin-induced-airways-inflammation-in-a-mouse-model-of-allergic-asthma
#7
Wenhao Xu, Meiqun Hu, Qihong Zhang, Jingbo Yu, Weike Su
ETHNOPHARMACOLOGICAL RELEVANCE: Cassia occidentalis Linn. is a traditional ayruvedic edible shrub containing anthraquinones (AQs) as the principle active constituents. In folk medicine, it has a variety of uses including treatment of whooping cough ('pertussis') and inflammatory diseases. Despite these applications, limited data are available to validate the effects of C. occidentalis AQs on airways inflammation in asthma. AIM OF THE STUDY: To explore the anti-inflammatory potential of AQs extracted from C...
April 9, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29648491/sublingual-administration-of-2-hydroxyethyl-methacrylate-enhances-antibody-responses-to-co-administered-ovalbumin-and-streptococcus-mutans
#8
Anna Karin Östberg, Sara Alizadehgharib, Ulf Dahlgren
OBJECTIVE: The oral mucosa of patients undergoing dental procedures is often exposed to residual monomers leaking from incompletely cured acrylic resins. We investigated whether 2-hydroxyethyl methacrylate (HEMA) monomers applied to the sublingual mucosa in mice modulate the antibody responses towards co-administered ovalbumin (OVA) or live oral bacteria. MATERIAL AND METHODS: OVA, live mouse oral commensal Lactobacillus murinus or live human oral commensal Streptococcus mutans were administered sublingually with or without HEMA to BALB/c mice on four weekly occasions...
April 12, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29643919/an-update-on-molecular-cat-allergens-fel-d-1-and-what-else-chapter-1-fel-d-1-the-major-cat-allergen
#9
REVIEW
B Bonnet, K Messaoudi, F Jacomet, E Michaud, J L Fauquert, D Caillaud, B Evrard
Background: Cats are the major source of indoor inhalant allergens after house dust mites. The global incidence of cat allergies is rising sharply, posing a major public health problem. Ten cat allergens have been identified. The major allergen responsible for symptoms is Fel d 1, a secretoglobin and not a lipocalin, making the cat a special case among mammals. Main body: Given its clinical predominance, it is essential to have a good knowledge of this allergenic fraction, including its basic structure, to understand the new exciting diagnostic and therapeutic applications currently in development...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29628971/establishment-of-a-chronic-obstructive-pulmonary-disease-mouse-model-based-on-the-elapsed-time-after-lps-intranasal-instillation
#10
Soon-Young Lee, Jin-Ho Cho, Seung Sik Cho, Chun-Sik Bae, Gye-Yeop Kim, Dae-Hun Park
Chronic obstructive pulmonary disease (COPD) was the 3rd leading cause of death in 2012 worldwide. It is particularly severe in the elderly, who are at risk of death by coughing, mucous hypersecretion, and finally breathlessness. Recently, anti-COPD drug development has increased, and many animal screening systems have been studied. Tobacco smoke animal models are the best known animal screening system, but have several preparation requirements, such as a tobacco smoke generator and a separate facility to prevent smoke release...
March 2018: Laboratory Animal Research
https://www.readbyqxmd.com/read/29618330/filaria-specific-antibody-response-profiling-in-plasma-from-anti-retroviral-na%C3%A3-ve-loa-loa-microfilaraemic-hiv-1-infected-people
#11
Ghislain Donald Njambe Priso, Abel Lissom, Loveline N Ngu, Nadesh N Nji, Jules Colince Tchadji, Thibau Flaurant Tchouangueu, Georgia E Ambada, Carole Stéphanie Sake Ngane, Brigitte Laure Dafeu, Larissa Djukouo, Inès Nyebe, Suzanne Magagoum, Apeh Alfred Ngoh, Ouambo Fotso Herve, Rosario Garcia, Anna Gutiérrez, Arinze S Okoli, Charles O Esimone, Flobert Njiokou, Chae Gyu Park, Alain Bopda Waffo, Godwin W Nchinda
BACKGROUND: In West and Central Africa areas of endemic Loa loa infections overlap with regions of high prevalence of human immunodeficiency virus type 1 (HIV-1) infections. Because individuals in this region are exposed to filarial parasites from birth, most HIV-1 infected individuals invariably also have a history of filarial parasite infection. Since HIV-1 infection both depletes immune system and maintains it in perpetual inflammation, this can hamper Loa loa filarial parasite mediated immune modulation, leading to enhanced loaisis...
April 4, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29616018/induction-of-interleukin-10-producing-dendritic-cells-as-a-tool-to-suppress-allergen-specific-t-helper-2-responses
#12
REVIEW
Stefan Schülke
Dendritic cells (DCs) are gatekeepers of the immune system that control induction and polarization of primary, antigen-specific immune responses. Depending on their maturation/activation status, the molecules expressed on their surface, and the cytokines produced DCs have been shown to either elicit immune responses through activation of effector T cells or induce tolerance through induction of either T cell anergy, regulatory T cells, or production of regulatory cytokines. Among the cytokines produced by tolerogenic DCs, interleukin 10 (IL-10) is a key regulatory cytokine limiting und ultimately terminating excessive T-cell responses to microbial pathogens to prevent chronic inflammation and tissue damage...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29615379/doxycycline-suppresses-chlamydia-pneumoniae-induced-interferon-gamma-responses-in-peripheral-blood-mononuclear-cells-in-children-with-allergic-asthma
#13
Tamar A Smith-Norowitz, Diana Weaver, Yitzchok M Norowitz, Margaret R Hammerschlag, Rauno Joks, Helen G Durkin, Stephan Kohlhoff
Persistent respiratory infections caused by Chlamydia pneumoniae have been implicated in the pathogenesis of chronic diseases (e.g. asthma). Antibiotics are used to treat C. pneumoniae respiratory infections; however, the use of antibiotics as anti-inflammatory agents in treatment of asthma remains controversial. The current study investigated whether ciprofloxacin, azithromycin, or doxycycline can suppress C. pneumoniae-induced production of immunoglobulin (Ig) E or cytokines in peripheral blood mononuclear cells (PBMC) obtained from asthmatic children...
March 31, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29613835/therapeutic-exploitation-of-ipse-a-urogenital-parasite-derived-host-modulatory-protein-for-chemotherapy-induced-hemorrhagic-cystitis
#14
Evaristus C Mbanefo, Loc Le, Luke F Pennington, Justin I Odegaard, Theodore S Jardetzky, Abdulaziz Alouffi, Franco H Falcone, Michael H Hsieh
Chemotherapy-induced hemorrhagic cystitis (CHC) can be difficult to manage. Prior work suggests that IL-4 alleviates ifosfamide-induced hemorrhagic cystitis (IHC), but systemically administered IL-4 causes significant side effects. We hypothesized that the Schistosoma hematobium homolog of IL-4-inducing principle from Schistosoma mansoni eggs (H-IPSE), would reduce IHC and associated bladder pathology. IPSE binds IgE on basophils and mast cells, triggering IL-4 secretion by these cells. IPSE is also an "infiltrin," translocating into the host nucleus to modulate gene transcription...
April 3, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29611659/comparison-of-serum-concentrations-of-environmental-allergen-specific-ige-in-atopic-and-healthy-nonatopic-horses
#15
P Wilkołek, W Sitkowski, M Szczepanik, Ł Adamek, M Pluta, I Taszkun, M Gołyński, A Malinowska
Allergic responses in humans, horses and other species are mediated by immunoglobulin E (IgE) antibodies. Serum testing to detect allergen-specific IgE antibodies has been developed for dogs, cats and horses; this allows for the identification of allergens and determination of appropriate allergen- specific immunotherapies. This study compared serum allergen-specific IgE concentrations in atopic and healthy horses. The study was performed on Malopolski breed atopic (n=21) and nonatopic (n=21) clinically healthy horses...
December 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29611440/new-biologics-for-allergic-diseases
#16
Laurie A Manka, Michael E Wechsler
Allergic conditions such as asthma and atopic dermatitis have a high prevalence but represent a heterogeneous group of diseases despite similar clinical presentation and underlying pathophysiology. A better understanding of the phenotypes and endotypes of these diseases has driven rapid development of biologic medications targeting many steps of the inflammatory pathways. Areas Covered: There are 2 major inflammatory pathways that drive allergic diseases: Type-2 (Th-2) inflammation and non-type 2 inflammation...
April 3, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29607480/prospective-study-in-bullous-pemphigoid-association-of-high-serum-anti-bp180-igg-levels-with-increased-mortality-and-reduced-karnofsky-score
#17
M M Holtsche, S Goletz, N van Beek, D Zillikens, S Benoit, K Harman, S Walton, J English, M Sticherling, A Chapman, N J Levell, R Groves, H C Williams, I R König, E Schmidt
BACKGROUND: Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by autoantibodies against the two hemidesmosomal proteins BP180 (type XVII collagen) and BP230. The multicenter prospective BLISTER (Bullous Pemphigoid Steroids and Tetracyclines) trial randomized 253 BP patients to compare the benefits and harms between initial treatment with doxycycline or prednisolone. OBJECTIVES: To analyze distinct autoantibody profiles for the prediction of the disease course in a well characterized cohort of BP sera...
April 1, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29604074/anti-schistosome-responses-after-four-annual-treatments
#18
Eric M Ndombi, Bernard Abudho, Nupur Kittur, Jennifer M Carter, Harrison Korir, Diana K Riner, Horace Ochanda, Yeuk-Mui Lee, W Evan Secor, Diana M Karanja, Daniel G Colley
AIM: This study evaluated potential changes in anti-schistosome immune responses in children from schools that received four rounds of annual mass drug administration (MDA) of praziquantel (PZQ). METHODS: In a repeated cross-sectional study design, 210 schistosome egg-positive children were recruited at baseline from schools in western Kenya (baseline group). Another 251 children of the same age range were recruited from the same schools and diagnosed for schistosome infection by microscopy (post-MDA group)...
March 31, 2018: Parasite Immunology
https://www.readbyqxmd.com/read/29601354/phenotypes-endotypes-driven-treatment-in-asthma
#19
Fulvio Braido, Angelica Tiotiu, Krzysztof Kowal, Stefan Mihaicuta, Plamena Novakova, Ipek Kivilcim Oguzulgen
PURPOSE OF REVIEW: Target therapy is the necessary step towards personalized medicine. The definition of asthma phenotypes and underlying mechanisms (endotypes) represent a key point in the development of new asthma treatments. Big data analysis, biomarker research and the availability of monoclonal antibodies, targeting specific cytokines is leading to the rapid evolution of knowledge. In this review, we sought to outline many of the recent advances in the field. RECENT FINDINGS: Several attempts have been made to identify asthma phenotypes, sometimes with contrasting results...
March 29, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29589263/combination-of-temperature-shift-and-hydrolysate-addition-regulates-anti-ige-monoclonal-antibody-charge-heterogeneity-in-chinese-hamster-ovary-cell-fed-batch-culture
#20
Chen Zheng, Chao Zhuang, Jinyan Qin, Yantian Chen, Qiang Fu, Hui Qian, Tong Wu, Yanchao Wang, Xiang Wu, Nianmin Qi
Charge heterogeneity has been broadly studied as a critical quality attribute during monoclonal antibody (mAb) production that may subsequently affect product stability and biopotency. However, the charge variation distribution is poorly controlled, so methods of more effective control need to be explored. In this study, the combined effects of temperature shift (37-34, 37-32, or 37-30 °C) and hydrolysate addition (0.100 g/L) to culture feed on the charge heterogeneity of anti-IgE mAb were investigated. The results showed that the distribution of charge variation was significantly regulated by the combination of hydrolysate addition with a highly sub-physiological temperature (34 °C)...
March 27, 2018: Cytotechnology
keyword
keyword
60304
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"