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https://www.readbyqxmd.com/read/29027379/impact-of-omalizumab-in-children-from-a-middle-income-country-with-severe-therapy-resistant-asthma-a-real-life-study
#1
Paulo M Pitrez, Rodrigo G de Souza, Cristian Roncada, Joao P Heinzmann-Filho, Giovana Santos, Leonardo A Pinto, Marcus H Jones, Renato T Stein
BACKGROUND: Severe asthma in children is a global health problem. Severe therapy-resistant asthma (STRA) in children is a major clinical challenge due to persistent symptoms despite high doses of corticosteroids and results in high public health costs. Omalizumab (anti-IgE monoclonal antibody) has been described as an effective add-on therapy in these patients. The characteristics of children with STRA from low- and middle-income countries have scarcely been reported, and no real-life study has been published on the effects of omalizumab in this group of patients...
October 13, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29024606/role-of-the-tslp-dc-ox40l-pathway-in-asthma-pathogenesis-and-airway-inflammation-in-mice
#2
Shuang Feng, Li Zhang, Xu-Hua Bian, Ying Luo, Guang-Hui Qin, Rui-Ming Shi
This study aims to explore the effect of the TSLP/DC/OX40L pathway in asthma pathogenesis and airway inflammation in mice. Sixty-five male BALF/c mice were divided into the control, asthma, IgG + asthma (IgG, 500 g/500 l, intratracheal injection of 50 l each time), LY294002 (OX40L inhibitor) + asthma (intratracheal injection of 2 mg/kg LY294002), and anti-TSLP + asthma (intratracheal injection of 500 ug/500 l TSLP antibody, 50 l each time) groups. ELISA was applied to measure the serum levels of IgE, ovalbumin (OVA)-sIgE, interleukin-4 (IL-4), IL-5, IL-13 and interferon-γ (IFN-γ), flow cytometry was employed to detect Treg cells and dendritic cell (DC) and lymphopoiesis...
October 12, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29018449/mechanisms-cofactors-and-augmenting-factors-involved-in-anaphylaxis
#3
REVIEW
Rosa Muñoz-Cano, Mariona Pascal, Giovanna Araujo, M J Goikoetxea, Antonio L Valero, Cesar Picado, Joan Bartra
Anaphylaxis is an acute and life-threatening systemic reaction. Many triggers have been described, including food, drug, and hymenoptera allergens, which are the most frequently involved. The mechanisms described in anaphylactic reactions are complex and implicate a diversity of pathways. Some of these mechanisms may be key to the development of the anaphylactic reaction, while others may only modify its severity. Although specific IgE, mast cells, and basophils are considered the principal players in anaphylaxis, alternative mechanisms have been proposed in non-IgE anaphylactic reactions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29017796/anti-inflammatory-effect-of-collagen-tripeptide-in-atopic-dermatitis
#4
Amiko Hakuta, Yukie Yamaguchi, Tomoko Okawa, Shoko Yamamoto, Yasuo Sakai, Michiko Aihara
BACKGROUND: Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disease in which type 2 allergic inflammation plays an important role. Collagen tripeptide (CTP) is a functional collagen fraction with a high content of Gly-X-Y tripeptides. OBJECTIVE: To examine the effect of CTP on inflammation in AD. METHODS: Levels of inflammatory cytokines and chemokines, such as thymus- and activation-regulated chemokine (TARC), macrophage-derived chemokine, and thymic stromal lymphopoietin (TSLP), were examined in human keratinocytes supplemented with or without CTP under AD-like inflammation...
September 28, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28990098/anti%C3%A2-inflammatory-effect-of-amomum%C3%A2-xanthioides-in-a-mouse-atopic-dermatitis-model
#5
Young-Ae Choi, Jin Kyeong Choi, Yong Hyun Jang, Soyoung Lee, Sang-Rae Lee, Jung Ho Choi, Jee Hun Park, Tae-Yong Shin, Sang-Hyun Kim
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. The present study investigated the effects of Amomum xanthioides extract (AXE) on AD‑like skin inflammation using a Dermatophagoides farinae extract (DFE) and 2,4‑dinitrochlorobenzene (DNCB)‑induced mouse AD model. Hematoxylin and eosin staining results demonstrated that repeated DFE/DNCB exposure markedly increased the thickening of the dermis and epidermis, in addition to the infiltration of eosinophils and mast cells. However, oral administration of AXE reduced these histopathological alterations in a dose‑dependent manner...
October 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28988729/allergic-reactions-to-antivenom-in-a-patient-bitten-twice-by-the-same-snake-within-a-month-a-rare-case-report-and-literature-review
#6
Fan-Jie Zeng, Cong Chen, Ming-Hua Liu
Antivenom is the most effective method currently available for the treatment of poisonous snake bite. Allergic reactions to antivenom have been reported in the past. Here we shared a case of allergic reactions to antivenom in an old male patient who was bitten twice by the same snake (probably same one) at the same biting site within a month whereas the patient did not show any allergic disorder in the first bitten. Envenomations twice in a short period time by the same kind of snake are very rare. Physician should be alert to the occurrence of allergic reactions in treating this type of patients with antivenom...
July 13, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28983485/anti-ige-treatment-for-disorders-other-than-asthma
#7
REVIEW
Jeffrey Stokes
Immunoglobulin E (IgE) plays a key role in the pathogenesis of many allergic diseases. Thus, IgE-mediated immunologic pathways are an attractive target for intervention in allergic diseases. Omalizumab is a recombinant humanized monoclonal antibody that binds IgE and has been used treat allergic asthma for over a decade. Currently, omalizumab is approved for the treatment of both allergic asthma and chronic spontaneous urticaria. Since IgE plays a critical role in other allergic diseases, anti-IgE therapy has been evaluated in other allergic diseases in small clinical trials and case reports...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28982287/preventive-effects-of-royal-jelly-against-anaphylactic-response-in-a-murine-model-of-cow-s-milk-allergy
#8
Malika Guendouz, Abir Haddi, Hadria Grar, Omar Kheroua, Djamel Saidi, Hanane Kaddouri
CONTEXT: Royal jelly (RJ) has long been used to promote human health. OBJECTIVE: The current study investigated the preventive effects of RJ against the development of a systemic and intestinal immune response in mice allergic to cow's milk proteins. MATERIALS AND METHODS: Balb/c mice treated orally for seven days with RJ at doses of 0.5, 1 and 1.5 g/kg were sensitized intraperitoneally with β-lactoglobulin (β-Lg). Serum IgG and IgE anti-β-Lg were determined by an enzyme-linked immunosorbent assay (ELISA)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28976750/inhibition-of-mast-cell-mediated-allergic-responses-by-arctii-fructus-extracts-and-its-main-compound-arctigenin
#9
Ji-Ye Kee, Seung-Heon Hong
The Arctium lappa (Arctii Fructus) seed and its major active compound, arctigenin (ARC), are known to have anti-cancer, anti-obesity, anti-osteoporosis, and anti-inflammatory activities. However, the effect of Arctii Fructus and ARC on mast cell-mediated allergic inflammation and the associated mechanism have not been elucidated. Therefore, we attempted to investigate the anti-allergic activity of Arctii Fructus and ARC on mast cells and experimental mouse models. Arctii Fructus water (AFW) or ethanol extract (AFE) and ARC reduced the production of histamine and pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, IL-8, and TNF-α in mast cells...
October 4, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28968274/critical-appraisal-of-the-unmet-needs-in-the-treatment-of-chronic-spontaneous-urticaria-with-omalizumab-an-italian-perspective
#10
Riccardo Asero, Giorgio W Canonica, Antonio Cristaudo, Maria T Fierro, Giampiero Girolomoni, Angelo V Marzano, Eustachio Nettis, Patrizia Pepe, Paolo Pigatto, Oliviero Rossi
PURPOSE OF REVIEW: The humanized anti-IgE antibody omalizumab has been available for patients with chronic spontaneous urticaria (CSU) in Italy since 2015. This review summarizes the unresolved issues and unmet therapeutic needs associated with omalizumab and discusses practical recommendations for its use in the management of CSU. RECENT FINDINGS: Although modern second-generation H1-antihistamines are the standard of care for patients with CSU, adjunctive treatments (including omalizumab) may be required for effective control of symptoms in many patients...
September 28, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28967978/topical-glucose-induces-claudin-1-and-filaggrin-expression-in-a-mouse-model-of-atopic-dermatitis-and-in-keratinocyte-culture-exerting-anti-inflammatory-effects-by-repairing-skin-barrier-function
#11
Kiyoko Yamada, Kenji Matsushita, Wang Jingshu, Takuro Kanekura
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Corticosteroids, which are widely used for AD treatment, have adverse effects, and alternative treatments are urgently needed. This study examined the effect of topical application of high-dose glucose on inflamed skin in a murine model of AD. High-dose glucose treatment on the ear reduced dermatitis scores and ear thicknesses in mite antigen-treated NC/Nga mice. The levels of thymus and activation-regulated chemokine (TARC), Th cytokines (interleukin (IL)-4, IL-5, IL-12, IL-13, and (interferon) IFN-γ), and IgE were decreased in the serum of high-dose glucose-treated mice...
October 2, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28965921/therapeutic-approaches-of-asthma-and-copd-overlap
#12
REVIEW
Mitsuko Kondo, Jun Tamaoki
Asthma and COPD overlap (ACO) is an important clinical phenotype, due to the low-health-related quality of life (QOL), rapid decline in lung function, frequent exacerbation, and high economic burden. However, no large-scaled therapeutic trials of ACO have been conducted. At present, ACO is treated according to asthma/COPD guidelines. The goals of ACO treatment are to relieve symptoms and improve QOL and lung functions. Treatment must also prevent disease progression, airway remodeling, exacerbation, complications, and comorbidities...
September 28, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28963930/oligomeric-proanthocyanidins-attenuate-airway-inflammation-in-asthma-by-inhibiting-dendritic-cells-maturation
#13
Yeshan Li, Qijun Yu, Wenxue Zhao, Jiaxiang Zhang, Wentao Liu, Mao Huang, Xiaoning Zeng
To date, although a promising anti-inflammatory activity of oligomeric proanthocyanidins (OPCs) has been observed in asthma, the mechanism responsible for these immunomodulatory properties remains obscure. Dendritic cells (DCs) that reside in the airway have been widely perceived as an important contributor to asthma. Our study was to demonstrate OPCs' effects on maturation and immunoregulation of pulmonary CD11c(+) dendritic cells (DCs). BALB/c mice were exposed to ovalbumin (OVA) to induce murine model of asthma...
September 27, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28963290/efficacy-and-safety-of-so-cheong-ryong-tang-in-treatment-of-perennial-allergic-rhinitis-study-protocol-for-a-double-blind-randomised-parallel-group-multicentre-trial
#14
Min-Hee Kim, Youme Ko, Jin-Hyang Ahn, Younghee Yun, Mi-Na Yun, Seong-Gyu Ko, Inhwa Choi
INTRODUCTION: So-Cheong-Ryong-Tang (SCRT) is a herbal medicine widely used in traditional medicine for treating allergic rhinitis (AR). In animal studies, SCRT has suppressed the progression of AR. The main purpose of this study is to assess the efficacy and safety of the SCRT for the treatment of perennial allergic rhinitis (PAR) and discover the underlying mechanisms resulting in anti-inflammatory effects in humans. METHODS AND ANALYSIS: We will conduct a double-blind, randomised, placebo-controlled, parallel-group, multicentre trial of Korean adults with PAR...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28955985/selective-depletion-of-basophils-ameliorates-immunoglobulin-e-mediated-anaphylaxis
#15
Takeshi Nakamura, Tomohiro Fukaya, Tomofumi Uto, Hideaki Takagi, Keiichi Arimura, Tetsuya Tono, Katsuaki Sato
Basophils, which are the rarest granulocytes, play crucial roles in protective immunity against parasites and development of allergic disorders. Although immunoglobulin (Ig)E-dependent responses via receptor for IgE (FcεRI) in basophils have been extensively studied, little is known about cell surface molecules that are selectively expressed on this cell subset to utilize the elimination in vivo through treatment with monoclonal antibody (mAb). Since CD200 receptor 3 (CD200R3) was exclusively expressed on basophils and mast cells (MCs) using a microarray screening, we have generated anti-CD200R3 mAb recognizing CD200R3A...
March 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28955750/correlation-between-cell-aggregation-and-antibody-production-in-ige-producing-plasma-cells
#16
Mari Hikosaka, Akihiko Murata, Miya Yoshino, Shin-Ichi Hayashi
Allergic conditions result in the increase of immunoglobulin (Ig)E-producing plasma cells (IgE-PCs); however, it is unclear how IgE production is qualitatively controlled. In this study, we found that IgE-PCs in spleen of immunized mice formed homotypic cell aggregates. By employing IgE-producing hybridomas (IgE-hybridomas) as a model of IgE-PCs, we showed that these cells formed aggregates in the presence of specific antigens (Ags). The formation of the Ag-induced cell aggregation involved secreted IgE and Fcγ receptor (FcγR)II/FcγRIII, but not FcεRs...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28955044/cell-penetrating-peptide-derived-from-human-eosinophil-cationic-protein-decreases-airway-allergic-inflammation
#17
Lin-Shien Fu, Yu-Rou Wu, Shun-Lung Fang, Jaw-Ji Tsai, Heng-Kuei Lin, Yee-Jun Chen, Ting-Yu Chen, Margaret Dah-Tsyr Chang
Cell penetrating peptide derived from human eosinophil cationic protein (CPPecp) is a 10-amino-acid peptide containing a core heparan sulfate (HS)-binding motif of human eosinophil cationic protein (ECP). It binds and penetrates bronchial epithelial cells without cytotoxic effects. Here we investigated airway-protective effects of CPPecp in BEAS-2B cell line and mite-induced airway allergic inflammation in BALB/c mice. In BEAS-2B cell, CPPecp decreases ECP-induced eotaxin mRNA expression. CPPecp also decreases eotaxin secretion and p-STAT6 activation induced by ECP, as well as by IL-4...
September 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28953957/ige-reactivity-to-%C3%AE-gal-in-relation-to-lyme-borreliosis
#18
Ivar Tjernberg, Carl Hamsten, Danijela Apostolovic, Marianne van Hage
BACKGROUND: An association between tick bites, the development of immunoglobulin E (IgE) antibodies to galactose-α-1, 3-galactose (α-Gal) and red meat allergy has recently been reported. Here we wanted to elucidate the relation between tick exposure, IgE antibodies to α-Gal and Lyme borreliosis (LB). METHODS: In the highly LB endemic area of Kalmar County, Sweden, serum samples and health inquiries from 518 blood donors were included. All sera were investigated for multiple IgG anti-Borrelia antibodies using a multiplex assay (recomBead, Mikrogen)...
2017: PloS One
https://www.readbyqxmd.com/read/28952069/anti-il-33-antibody-has-a-therapeutic-effect-in-an-atopic-dermatitis-murine-model-induced-by-2-4-dinitrochlorobenzene
#19
Ge Peng, Zhenzhen Mu, Lixia Cui, Pengyue Liu, Ying Wang, Wenqing Wu, Xiuping Han
IL-33 is a new member of the IL-1 family that plays a role in allergic disease. In this study, we evaluated the potential on the inhibition of atopic dermatitis (AD) of anti-mouse IL-33 antibody (αIL-33Ab) using 2, 4-dinitrochlorobenzene (DNCB)-induced AD mice model. We treated mice with αIL-33Ab via subcutaneous injection of each DNCB treatment 1 h later from day 1 to day 33 for 14 times. A control group received tacrolimus. Skin lesion and scratching behavior were compared. Ear thickness, dermatitis score, eosinophils and mast cells infiltration, and serum IgE levels were also analyzed...
September 26, 2017: Inflammation
https://www.readbyqxmd.com/read/28949387/saponin-enriched-extract-of-asparagus-cochinchinensis-alleviates-airway-inflammation-and-remodeling-in-ovalbumin-induced-asthma-model
#20
Ji-Eun Sung, Hyun-Ah Lee, Ji-Eun Kim, Woo-Bin Yun, Beum-Soo An, Seung-Yun Yang, Dong-Seob Kim, Chung-Yeoul Lee, Hee-Seob Lee, Chang-Joon Bae, Dae-Youn Hwang
Asthma is a chronic inflammatory disease characterized by T-lymphocyte and eosinophil infiltration, mucus overproduction and airway hyper-responsiveness. The present study examined the therapeutic effects and action mechanism of a saponin-enriched extract of Asparagus cochinchinensis (SEAC) on airway inflammation and remodeling in an ovalbumin (OVA)-induced asthma model. To accomplish this, alterations of the nitric oxide (NO) level, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression levels, as well as variations in immune cell numbers, immunoglobulin E (IgE) concentration, histopathological structure and inflammatory cytokine levels were measured in lipopolysaccharide (LPS)-activated RAW264...
September 21, 2017: International Journal of Molecular Medicine
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