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https://www.readbyqxmd.com/read/28106215/the-degree-of-processing-of-foods-which-are-most-widely-consumed-by-the-french-elderly-population-is-associated-with-satiety-and-glycemic-potentials-and-nutrient-profiles
#1
Anthony Fardet, Caroline Méjean, Hélène Labouré, Valentina A Andreeva, Gilles Feron
Food processing impacts both food structure and nutritional density. The effect of food structure on satiety and glycemic potentials is well recognized. However, the association between processing, satiety and glycemic potentials and nutrient profiles has not been much studied, especially in the diets of the elderly. Therefore, this study aimed at exploring relations between the level of food processing, consumption and nutrient profiles and satiety and glycemic potentials among 6686 French elderly people (≥65 years)...
January 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28103600/indicators-of-adiposity-predictors-of-metabolic-syndrome-in-the-elderly
#2
Carolina Cunha de Oliveira, Anna Karla C Roriz, Lilian B Ramos, Mansueto Gomes Neto
BACKGROUND: Adiposity indicators can be used as predictors of cardiovascular risk in the elderly. However, there are only a very few studies that deal with the accuracy of adiposity indicators as predictors of metabolic syndrome (MS) in the elderly. We evaluated the performance of adiposity indicators of MS prediction in the elderly. METHODS: A cross-sectional study with 203 elderly people of both genders. VARIABLES: MS defined by harmonized criteria, waist circumference (WC), waist-to-height ratio (WHtR), conicity index (CI), lipid accumulation product (LAP), and visceral adiposity index (VAI)...
January 20, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28103493/individual-educational-attainment-neighborhood-socioeconomic-contexts-and-self-rated-health-of-middle-aged-and-elderly-chinese-exploring-the-mediating-role-of-social-engagement
#3
Wei Zhang, Yan Yan Wu
Analyzing the 2011-2013 China Health and Retirement Longitudinal Study with 14,507 respondents from 393 neighborhoods, and applying generalized linear mixed-effects model, this study examines how individual-level education and neighborhood-socioeconomic contexts affect health through social engagement. Findings reveal that measures of social engagement-social activity and productive activity-are significantly related to self-rated health and partially mediate the effects of individual-level education. Neighborhood-socioeconomic contexts have independent effects on self-rated health beyond individual socio-demographics, and social activity mediates the effects of neighborhood recreational facilities...
January 16, 2017: Health & Place
https://www.readbyqxmd.com/read/28103300/expression-profiling-of-ribosome-biogenesis-factors-reveals-nucleolin-as-a-novel-potential-marker-to-predict-outcome-in-aml-patients
#4
Virginie Marcel, Frédéric Catez, Caroline M Berger, Emeline Perrial, Adriana Plesa, Xavier Thomas, Eve Mattei, Sandrine Hayette, Pierre Saintigny, Philippe Bouvet, Jean-Jacques Diaz, Charles Dumontet
Acute myeloid leukemia (AML) is a heterogeneous disease. Prognosis is mainly influenced by patient age at diagnosis and cytogenetic alterations, two of the main factors currently used in AML patient risk stratification. However, additional criteria are required to improve the current risk classification and better adapt patient care. In neoplastic cells, ribosome biogenesis is increased to sustain the high proliferation rate and ribosome composition is altered to modulate specific gene expression driving tumorigenesis...
2017: PloS One
https://www.readbyqxmd.com/read/28096973/a-fission-yeast-cell-based-system-for-multidrug-resistant-hiv-1-proteases
#5
Zsigmond Benko, Dong Liang, Ge Li, Robert T Elder, Anindya Sarkar, Jun Takayama, Arun K Ghosh, Richard Y Zhao
BACKGROUND: HIV-1 protease (PR) is an essential enzyme for viral production. Thus, PR inhibitors (PIs) are the most effective class of anti-HIV drugs. However, the main challenge to the successful use of PI drugs in patient treatment is the emergence of multidrug resistant PRs (mdrPRs). This study aimed to develop a fission yeast cell-based system for rapid testing of new PIs that combat mdrPRs. RESULTS: Three mdrPRs were isolated from HIV-infected patients that carried seven (M7PR), ten (M10PR) and eleven (M11PR) PR gene mutations, respectively...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28095290/study-of-the-microbiological-quality-of-bulgarian-bottled-water-in-terms-of-its-contamination-with-pseudomonas-aeruginosa
#6
Vesela Georgieva, Yulia Dimitrova
BACKGROUND: Due to the widespread use of bottled water, it is important from a hygienic point of view to ensure that these products have good quality and meet the requirements set out in regulations. METHODS: In the period 2000-2013, a large-scale study (2,500 samples) was carried out on the quality of Bulgarian bottled water as per the microbiological parameters laid down in the European and Bulgarian legislation. Standard microbiological methods were applied. RESULTS: There is strong evidence that the most frequently isolated contaminant in these products was Pseudomonas aeruginosa...
December 2016: Central European Journal of Public Health
https://www.readbyqxmd.com/read/28095033/detection-of-the-toughest-pedestrian-injury-risk-as-a-smooth-function-of-age
#7
Tobias Niebuhr, Mirko Junge
OBJECTIVE: While it is common to regard age-specific groups (e.g. children, adults, elderly), smooth trends conditional on the age are mainly ignored in the literature. The present study examines the pedestrian injury risk in full-frontal pedestrian to passenger car accidents and incorporates the age -besides the collision speed and the injury severity- as a plug-in parameter. METHODS: Recent work introduced a model for pedestrian injury risk functions using explicit formulae with easily interpretable model parameters...
January 17, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28090008/characterization-of-the-growth-of-deep-and-subcortical-white-matter-hyperintensity-on-mr-imaging-a-retrospective-cohort-study
#8
Michito Adachi, Takamichi Sato
PURPOSE: In elderly patients, deep and subcortical white matter hyperintense lesions are frequently observed on MRI; however, the growth process of these lesions is unclear. The aims of this retrospective cohort study were to elucidate the growth characteristics of deep and subcortical white matter hyperintense lesions, and to insight their etiology. MATERIALS AND METHODS: We enrolled 103 patients (1610 lesions) whose deep and subcortical white matter hyperintense lesions were monitored for 3 or more years by MRI examination...
January 13, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28088236/economic-burden-of-family-caregiving-for-elderly-population-in-southern-ghana-the-case-of-a-peri-urban-district
#9
Stephen Tettey Nortey, Genevieve Cecilia Aryeetey, Moses Aikins, Djesika Amendah, Justice Nonvignon
BACKGROUND: Health systems in low and lower-middle income countries, particularly in sub-Sahara Africa, often lack the specialized personnel and infrastructure to provide comprehensive care for elderly/ageing populations. Close-to-client community-based approaches are a low-cost way of providing basic care and social support for elderly populations in such resource-constrained settings and family caregivers play a crucial role in that regard. However, family caregiving duties are often unremunerated and their care-related economic burden is often overlooked though this knowledge is important in designing or scaling up effective interventions...
January 14, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28079228/attenuated-recovery-of-contractile-function-in-aging-hearts-following-global-ischemia-reperfusion-role-of-extracellular-hsp27-and-tlr4
#10
Lihua Ao, Yufeng Zhai, Chunhua Jin, Joseph C Cleveland, David A Fullerton, Xianzhong Meng
BACKGROUND: While cardiac functional recovery is attenuated in the elderly following cardiac surgery with obligatory global myocardial ischemia/reperfusion (I/R), the underlying mechanism remains incompletely understood. We observed previously that human and mouse myocardium releases heat shock protein (HSP) 27 during global I/R. Extracellular HSP27 induces myocardial inflammatory response and plays a role in post-ischemic cardiac dysfunction in adult mouse hearts. OBJECTIVE: This study was to determine the role of extracellular HSP27 and Toll-like receptor 4 (TLR4) in the attenuated functional recovery in aging mouse hearts following global I/R...
December 19, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/28065928/unveiling-the-osmophores-of-philodendron-adamantinum-araceae-as-a-means-to-understanding-interactions-with-pollinators
#11
Patrícia Gonçalves-Souza, Clemens Schlindwein, Stefan Dötterl, Elder Antônio Sousa Paiva
BACKGROUND AND AIMS: Araceae species pollinated by nocturnal Cyclocephalini beetles attract their pollinators by inflorescence scents. In Philodendron, despite the intense odour, the osmophores exhibit no definite morphological identity, making them difficult to locate. This may explain why structural studies of the scent-releasing tissue are not available so far. METHODS: Several approaches were employed for locating and understanding the osmophores of Philodendron adamantinum A sensory test allowed other analyses to be restricted to fertile and sterile stamens as odour production sites...
January 8, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28062184/c-jun-n-terminal-kinase-activity-is-required-for-efficient-respiratory-syncytial-virus-production
#12
Leon Caly, Hong-Mei Li, Marie A Bogoyevitch, David A Jans
Respiratory syncytial virus (RSV) is a major cause of respiratory infections in infants and the elderly, leading to more deaths than influenza each year worldwide. With no RSV antiviral or efficacious vaccine currently available, improved understanding of the host-RSV interaction is urgently required. Here we examine the contribution to RSV infection of the host stress-regulated c-Jun N-terminal kinase (JNK), for the first time. Peak JNK1/2 phosphoactivation is observed at ∼24 h post-infection, correlating with the time of virus assembly...
January 3, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28060908/experimental-mouse-model-of-lumbar-ligamentum-flavum-hypertrophy
#13
Takeyuki Saito, Kazuya Yokota, Kazu Kobayakawa, Masamitsu Hara, Kensuke Kubota, Katsumi Harimaya, Kenichi Kawaguchi, Mitsumasa Hayashida, Yoshihiro Matsumoto, Toshio Doi, Keiichiro Shiba, Yasuharu Nakashima, Seiji Okada
Lumbar spinal canal stenosis (LSCS) is one of the most common spinal disorders in elderly people, with the number of LSCS patients increasing due to the aging of the population. The ligamentum flavum (LF) is a spinal ligament located in the interior of the vertebral canal, and hypertrophy of the LF, which causes the direct compression of the nerve roots and/or cauda equine, is a major cause of LSCS. Although there have been previous studies on LF hypertrophy, its pathomechanism remains unclear. The purpose of this study is to establish a relevant mouse model of LF hypertrophy and to examine disease-related factors...
2017: PloS One
https://www.readbyqxmd.com/read/28051247/supplementation-with-high-titer-cranberry-extract-anthocran%C3%A2-for-the-prevention-of-recurrent-urinary-tract-infections-in-elderly-men-suffering-from-moderate-prostatic-hyperplasia-a-pilot-study
#14
A Ledda, G Belcaro, M Dugall, B Feragalli, A Riva, S Togni, L Giacomelli
OBJECTIVE: Recently, cranberry extracts have been tested as a nutritional supplementation in the prevention of lower urinary tract symptoms (LUTS) as well as recurrent urinary tract infections (UTIs) in subjects at risk, with mixed results. However, evidence of efficacy should be considered only for well-characterized and standardized products in a more selected study population. Moreover, the efficacy of these interventions in elderly must be further investigated. The aim of this pilot, registry study was to evaluate the prophylactic effects of an oral supplementation containing a highly concentrated and standardized cranberry extract reproducing the natural total profile of cranberry fruits, in elderly men with benign prostatic hyperplasia (BPH), suffering from recurrent UTIs, over a 2-months follow-up...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28049401/alzheimer-s-disease-and-natural-products-future-regimens-emerging-from-nature
#15
Md Asiful Islam, Shahad Saif Khandker, Fahmida Alam, Md Ibrahim Khalil, Mohammad Amjad Kamal, Siew Hua Gan
Alzheimer's disease (AD), which largely affects the elderly, has become a global burden. Patients with AD have both short- and long-term memory impairments. The neuronal loss in AD occurs due to abnormally folded amyloid beta proteins and aggregation of hyperphosphorylated tau proteins in the brain. Eventually, amyloid plaques and neurofibrillary tangles are formed, which subsequently disintegrate the neuronal transport system. There are several factors which are involved in AD pathogenesis, including oxidative stress, inflammation and the presence of metal ions...
January 3, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28043897/natural-products-against-alzheimer-s-disease-pharmaco-therapeutics-and-biotechnological-interventions
#16
REVIEW
Abhijit Dey, Raktim Bhattacharya, Anuradha Mukherjee, Devendra Kumar Pandey
Alzheimer's disease (AD) is a severe, chronic and progressive neurodegenerative disease associated with memory and cognition impairment ultimately leading to death. It is the commonest reason of dementia in elderly populations mostly affecting beyond the age of 65. The pathogenesis is indicated by accumulation of the amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFT) in brain tissues and hyperphosphorylation of tau protein in neurons. The main cause is considered to be the formation of reactive oxygen species (ROS) due to oxidative stress...
December 30, 2016: Biotechnology Advances
https://www.readbyqxmd.com/read/28038993/inflammaging-and-omics-in-human-longevity
#17
REVIEW
Daniela Monti, Rita Ostan, Vincenzo Borelli, Gastone Castellani, Claudio Franceschi
Inflammaging is a recent theory of aging originally proposed in 2000 where data and conceptualizations regarding the aging of the immune system (immunosenescence) and the evolution of immune responses from invertebrates to mammals converged. This theory has received an increasing number of citations and experimental confirmations. Here we present an updated version of inflammaging focused on omic data - particularly on glycomics - collected on centenarians, supercentenarians and their offspring. Accordingly, we arrived to the following conclusions: i) inflammaging has a structure where specific combinations of pro- and anti-inflammatory mediators are involved; ii) inflammaging is systemic and more complex than we previously thought, as many organs, tissues and cell types participate in producing pro- and anti-inflammatory stimuli conceptualized as "molecular garbage"; iii) inflammaging is dynamic, can be propagated locally to neighboring cells and systemically from organ to organ by circulating products and microvesicles, and amplified by chronic age-related diseases constituting a "local fire" which in turn produces additional inflammatory stimuli and molecular garbage; iv) an integrated Systems Medicine approach is urgently needed to let emerge a robust and highly informative set/combination of omic markers able to better grasp the complex molecular core of inflammaging in elderly and centenarians...
December 27, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28034724/disruption-of-transforming-growth-factor-%C3%AE-superfamily-signaling-a-shared-mechanism-underlying-hereditary-cerebral-small-vessel-disease
#18
REVIEW
Yumi Yamamoto, Masafumi Ihara
Cerebral small vessel disease (SVD) is not only one of the leading causes of cognitive impairment but also an important contributory factor in Alzheimer's disease. SVD and related white matter changes are common in the elderly, but the underlying pathogenic mechanism remains unclear. The end-stage pathology of SVD often involves replacement of vascular smooth muscle cells with collagenous or other nontensile fibrillary material. Recent studies on hereditary SVD have revealed a close relationship between small vessel pathology and disruption of transforming growth factor-β (TGF-β) superfamily signaling...
December 26, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/28034409/visualizing-the-knowledge-structure-and-evolution-of-big-data-research-in-healthcare-informatics
#19
REVIEW
Dongxiao Gu, Jingjing Li, Xingguo Li, Changyong Liang
BACKGROUND: In recent years, the literature associated with healthcare big data has grown rapidly, but few studies have used bibliometrics and a visualization approach to conduct deep mining and reveal a panorama of the healthcare big data field. METHODS: To explore the foundational knowledge and research hotspots of big data research in the field of healthcare informatics, this study conducted a series of bibliometric analyses on the related literature, including papers' production trends in the field and the trend of each paper's co-author number, the distribution of core institutions and countries, the core literature distribution, the related information of prolific authors and innovation paths in the field, a keyword co-occurrence analysis, and research hotspots and trends for the future...
February 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28003336/polysialic-acid-blocks-mononuclear-phagocyte-reactivity-inhibits-complement-activation-and-protects-from-vascular-damage-in-the-retina
#20
Marcus Karlstetter, Jens Kopatz, Alexander Aslanidis, Anahita Shahraz, Albert Caramoy, Bettina Linnartz-Gerlach, Yuchen Lin, Anika Lückoff, Sascha Fauser, Katharina Düker, Janine Claude, Yiner Wang, Johannes Ackermann, Tobias Schmidt, Veit Hornung, Christine Skerka, Thomas Langmann, Harald Neumann
Age-related macular degeneration (AMD) is a major cause of blindness in the elderly population. Its pathophysiology is linked to reactive oxygen species (ROS) and activation of the complement system. Sialic acid polymers prevent ROS production of human mononuclear phagocytes via the inhibitory sialic acid-binding immunoglobulin-like lectin-11 (SIGLEC11) receptor. Here, we show that low-dose intravitreal injection of low molecular weight polysialic acid with average degree of polymerization 20 (polySia avDP20) in humanized transgenic mice expressing SIGLEC11 on mononuclear phagocytes reduced their reactivity and vascular leakage induced by laser coagulation...
December 21, 2016: EMBO Molecular Medicine
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