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https://www.readbyqxmd.com/read/27910810/production-of-tnf-alpha-ex-vivo-is-predictive-of-an-immune-response-to-flu-vaccination-in-a-frail-elderly-population
#1
Frédéric Bloch, Bénédicte Charmeteau, Michael Tovey, Jean-François Meritet, Corinne Desaint, Odile Launay, Pierre Lebon
OBJECTIVE: To investigate the relationship between the response to influenza vaccination and the ability to produce proinflamatory cytokines in elderly subjects. METHODS: Whole blood samples from 25 elderly subjects collected before influenza vaccination were stimulated with the influenza vaccine in order to evaluate the secretion of five specific cytokines: TNFα, IFNα, IFNγ, IL2 and IL10. The results were correlated with the increased HAI antibody titres two weeks after vaccination...
September 1, 2016: European Cytokine Network
https://www.readbyqxmd.com/read/27904100/usefulness-of-oral-care-related-information-provision-at-drugstores-to-prevent-pneumonia
#2
Masaru Mizoguchi, Sako Kuwano, Ikuko Suzuki, Masato Shigeyama
 Although the removal of bacteria in the oral cavity is regarded as an important preventive measure against pneumonia, the majority of elderly individuals are rarely provided with oral care-related information. This study examined the usefulness of oral care-related information provision for the elderly by pharmacists working at drugstores. A questionnaire survey was conducted, involving 387 pharmacists working at drugstores and 51 elderly individuals who visited such stores. Oral care-related information had been actively provided by 14...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27903092/habitual-intake-of-fermented-milk-products-containing-lactobacillus-casei-strain-shirota-and-a-reduced-risk-of-hypertension-in-older-people
#3
Y Aoyagi, S Park, S Matsubara, Y Honda, R Amamoto, A Kushiro, K Miyazaki, R J Shephard
This study investigated relationships between the frequent intake of fermented milk products containing Lactobacillus casei strain Shirota (LcS) and the onset of hypertension (resting systemic pressure ≥140 mmHg [systolic]/≥90 mmHg [diastolic], a doctor's diagnosis and/or antihypertensive medicine use) during a 5-year period in 352 communityliving Japanese aged 65 to 93 years (125 men and 227 women). Initially normotensive subjects were divided into two groups (n=254 and n=98) on the basis of their intake of fermented milk products (<3 or ≥3 times/week, respectively), as estimated during an interview by a certified nutritionist...
December 1, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27900531/accidental-cannabis-poisoning-in-the-elderly
#4
Anja Zupan Mežnar, Miran Brvar, Gregor Kralj, Dragan Kovačič
There are two main varieties of Cannabis sativa plant, namely, hemp which is cultivated for fiber and seeds and contains low amounts of psychoactive cannabinoids and the other which is cultivated for the drug cannabis or marijuana. Increasing popularity of hemp food products and alleged beneficial effects of cannabinoids in the drug variety of cannabis might lead to confusion in the lay population and unintentional ingestion of marijuana, as described in this case report. During a workshop on the use of hemp for medicinal purposes, there was a degustation of various hemp food products including also cookies that were brought by one of the attendees...
November 29, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27899143/presymptomatic-diagnosis-of-fabry-s-disease-a-case-report
#5
Rasmus Bo Hasselbalch, Per Lav Madsen, Henning Bundgaard, Juliane Theilade
BACKGROUND: Fabry's disease is a rare X-linked genetic disorder characterized by reduced levels of the α-galactosidase A enzyme. It may present with a cardiac phenotype resembling hypertrophic cardiomyopathy. However, as a specific enzyme replacement therapy is available, it remains an important differential diagnoses in patients presenting with cardiac hypertrophy. In boys, onset has been reported in early childhood with complaints initially comprising neuropathic pain, reduced sweat production, and gastrointestinal symptoms...
November 29, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27895390/maslinic-acid-in-olive-fruit-alleviates-mild-knee-joint-pain-and-improves-quality-of-life-by-promoting-weight-loss-in-the-elderly
#6
Satoshi Fukumitsu, Myra O Villareal, Kazuhiko Aida, Akihiro Hino, Noriya Hori, Hiroko Isoda, Yuji Naito
Consumption of olives (Olea europaea L.) is associated with a low incidence of inflammation-related diseases. Olive fruit is rich in bioactive pentacyclic triterpenoids, mainly maslinic acid. This study, a randomized, double-blind, and placebo-controlled trial, examined the effects of an orally administered maslinic acid supplement, olive fruit extract, on 20 middle-aged and elderly volunteers with mild knee joint pain. Each subject (58 ± 7 years) received either olive fruit extract, containing 50 mg maslinic acid (n = 12), or placebo (n = 8) daily for 12 weeks and evaluated for pain and physical functions as primary outcome measures...
November 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27892875/the-zoonotic-potential-of-lactococcus-garvieae-an-overview-on-microbiology-epidemiology-virulence-factors-and-relationship-with-its-presence-in-foods
#7
REVIEW
Alicia Gibello, Fátima Galán-Sánchez, M Mar Blanco, Manuel Rodríguez-Iglesias, Lucas Domínguez, José F Fernández-Garayzábal
Lactococcus garvieae is a relevant worldwide fish pathogen affecting various farmed and wild marine and freshwater species. It has also been isolated from other animals, such as ruminants with subclinical mastitis and pigs with pneumonia. From the early 90s, L. garvieae has been associated with different human infections, mainly endocarditis. During the last five years, human infections by this bacterium appear to be increasing, likely due to the improvement in microbiological methods for bacterial identification and the alertness of this bacterium by physicians...
September 17, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27885155/job-crafting-employee-well-being-and-quality-of-care
#8
Montserrat Yepes-Baldó, Marina Romeo, Kristina Westerberg, Maria Nordin
The main objective is to study the effects of job crafting activities of elder care and nursing home employees on their perceived well-being and quality of care in two European countries, Spain and Sweden. The Job Crafting, the General Health, and the Quality of Care questionnaires were administered to 530 employees. Correlations and hierarchical regression analyses were performed. Results confirm the effects of job crafting on quality of care (r = .291, p < .01; β = .261, p < .01; ΔR(2) = .065, p < ...
November 24, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/27884595/melatonin-protection-against-age-related-cardiac-pathology
#9
REVIEW
Gaia Favero, Lorenzo Franceschetti, Barbara Buffoli, Moghadasian H Mohammed, Russel J Reiter, Luigi Fabrizio Rodella, Rita Rezzani
Aging is a complex and progressive process that involves physiological and metabolic deterioration in every organ and system. Cardiovascular diseases are one of the most common causes of mortality and morbidity among elderly subjects worldwide. Most age-related cardiovascular disorders can be influenced by modifiable behaviours such as a healthy diet rich in fruit and vegetables, avoidance of smoking, increased physical activity and reduced stress. The role of diet in prevention of various disorders is a well-established factor, which has an even more important role in the geriatric population...
November 21, 2016: Ageing Research Reviews
https://www.readbyqxmd.com/read/27880854/increased-paternal-age-at-conception-is-associated-with-transcriptomic-changes-involved-in-mitochondrial-function-in-elderly-individuals
#10
Tapio Nevalainen, Laura Kananen, Saara Marttila, Juulia Jylhävä, Marja Jylhä, Antti Hervonen, Mikko Hurme
The increased paternal age at conception (PAC) has been associated with autism spectrum disorder (ASD), schizophrenia and other neurodevelopmental disorders, thus raising questions that imply, potential health concerns in the offspring. As opposed to female oogonia, the male germ cells undergo hundreds of cell divisions during the fertile years. Thus, the advanced paternal age is associated with increase of point mutations in the male spermatogonia DNA, implying that this could be the major driving mechanism behind the paternal age effect observed in the offspring...
2016: PloS One
https://www.readbyqxmd.com/read/27878710/the-differential-effect-of-compensation-structures-on-the-likelihood-that-firms-accept-new-patients-by-insurance-type
#11
Justin B Bullock, W David Bradford
Adequate access to primary care is not universally achieved in many countries, including the United States, particularly for vulnerable populations. In this paper we use multiple years of the U.S.-based Community Tracking Survey to examine whether a variety of physician compensation structures chosen by practices influence the likelihood that the practice takes new patients from a variety of different types of insurance. Specifically, we examine the roles of customer satisfaction and quality measures on the one hand, and individual physician productivity measures on the other hand, in determining whether or not firms are more likely to accept patients who have private insurance, Medicare, or Medicaid...
March 2016: Int J Health Econ Manag
https://www.readbyqxmd.com/read/27847651/ethylene-glycol-poisoning-an-unusual-cause-of-altered-mental-status-and-the-lessons-learned-from-management-of-the-disease-in-the-acute-setting
#12
R Singh, E Arain, A Buth, J Kado, A Soubani, N Imran
Ethylene glycol is found in many household products and is a common toxic ingestion. Acute ingestions present with altered sensorium and an osmolal gap. The true toxicity of ethylene glycol is mediated by its metabolites, which are responsible for the increased anion gap metabolic acidosis, renal tubular damage, and crystalluria seen later in ingestions. Early intervention is key; however, diagnosis is often delayed, especially in elderly patients presenting with altered mental status. There are several laboratory tests which can be exploited for the diagnosis, quantification of ingestion, and monitoring of treatment, including the lactate and osmolal gaps...
2016: Case Reports in Critical Care
https://www.readbyqxmd.com/read/27842443/clinical-update-on-benefit-versus-risks-of-oral-paracetamol-alone-or-with-codeine-still-a-good-option
#13
Hans Georg Kress, Gerald Untersteiner
BACKGROUND: After decades of worldwide use of paracetamol/acetaminophen as a popular and apparently safe prescription and over-the-counter medicine, the future role of this poorly understood analgesic has been seriously questioned by recent concerns about prenatal, cardiovascular (CV) and hepatic safety, and also about its analgesic efficacy. At the same time the usefulness of codeine in combination products has come under debate. METHODS: Based on a PubMed database literature search on the terms efficacy, safety, paracetamol, acetaminophen, codeine and their combinations up to and including June 2016, this clinical update reviews the current evidence of the benefit and risks of oral paracetamol alone and with codeine for mild-to-moderate pain in adults, and compares the respective efficacy and safety profiles with those of nonsteroidal anti-inflammatory drugs (NSAIDs)...
November 15, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27837111/age-associated-b-cells-with-proinflammatory-characteristics-are-expanded-in-a-proportion-of-multiple-sclerosis-patients
#14
Nele Claes, Judith Fraussen, Marjan Vanheusden, Niels Hellings, Piet Stinissen, Bart Van Wijmeersch, Raymond Hupperts, Veerle Somers
Immune aging occurs in the elderly and in autoimmune diseases. Recently, IgD(-)CD27(-) (double negative, DN) and CD21(-)CD11c(+) (CD21(low)) B cells were described as age-associated B cells with proinflammatory characteristics. This study investigated the prevalence and functional characteristics of DN and CD21(low) B cells in multiple sclerosis (MS) patients. Using flow cytometry, we demonstrated a higher proportion of MS patients younger than 60 y with peripheral expansions of DN (8/41) and CD21(low) (9/41) B cells compared with age-matched healthy donors (1/33 and 2/33, respectively), which indicates an increase in age-associated B cells in MS patients...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27836898/dung-biomass-smoke-activates-inflammatory-signaling-pathways-in-human-small-airway-epithelial-cells
#15
Claire E McCarthy, Parker F Duffney, Robert Gelein, Thomas H Thatcher, Alison C P Elder, Richard P Phipps, Patricia J Sime
Animal dung is a biomass fuel burned by vulnerable populations who cannot afford cleaner sources of energy, such as wood and gas, for cooking and heating their homes. Exposure to biomass smoke is the leading environmental risk for mortality, with over 4 million deaths each year worldwide attributed to indoor air pollution from biomass smoke. Biomass smoke inhalation is epidemiologically associated with pulmonary diseases, including Chronic Obstructive Pulmonary Disease (COPD), lung cancer, and respiratory infections, especially in low and middle-income countries...
November 11, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27834606/the-missing-link-to-patient-engagement-in-italy
#16
Rocco Palumbo, Carmela Annarumma, Paola Adinolfi, Marco Musella
Purpose The purpose of this paper is to discuss the changing patterns of users' behavior in the health care service system. Although patient engagement and health services' co-production are understood as essential ingredients in the recipe for sustainable health systems, some determinants to patient involvement are still widely neglected by both policy makers and health care professionals. Among others, inadequate health literacy performs as a significant barrier to patient empowerment. Design/methodology/approach A survey aimed at objectively measuring health literacy-related skills was administered to a random sample of 600 Italian patients...
November 21, 2016: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/27830522/accuracy-of-ecg-indices-for-diagnosis-of-left-ventricular-hypertrophy-in-people-65%C3%A2-years-results-from-the-actife-study
#17
Roman Laszlo, Katia Kunz, Dhayana Dallmeier, Jochen Klenk, Michael Denkinger, Wolfgang Koenig, Dietrich Rothenbacher, Juergen Michael Steinacker
BACKGROUND: The detection of left ventricular hypertrophy (LVH) is still a common objective of electrocardiography (ECG) in clinical practice. AIMS: The aim of our study was to evaluate the accuracy of LVH ECG indices in people older than 65 recruited from a population-based cohort (ActiFE-Ulm study). METHODS: In 432 subjects (mean age 76.2 ± 5.5 years, 51% male), left ventricular mass was echocardiographically determined (Devereux formula) and indexed (LVMI) to body surface area...
November 9, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27828665/aerobic-training-modulates-t-cell-activation-in-elderly-women-with-knee-osteoarthritis
#18
W F Gomes, A C R Lacerda, G E A Brito-Melo, S F Fonseca, E Rocha-Vieira, A A O Leopoldino, M R Amorim, V A Mendonça
Osteoarthritis of the knee (kOA) is a disease that mainly affects the elderly and can lead to major physical and functional limitations. However, the specific effects of walking, particularly on the immune system, are unknown. Therefore, this study aimed to analyze the effect of 12 weeks of walking (3×/week) on the leukocyte profile and quality of life (QL) of elderly women with kOA. Sixteen women (age: 67±4 years, body mass index: 28.07±4.16 kg/m2) participated in a walking program. The variables were assessed before and after 12 weeks of training with a progressively longer duration (30-55 min) and higher intensity (72-82% of HRmax determined using a graded incremental treadmill test)...
2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/27828599/effect-of-estrogen-administration-on-middle-cerebral-arterial-viscoelastic-properties-in-aged-female-rats
#19
Zhigang Qin, Guijie Li, Naijie Liu, Conghai Zhao, Hang Zhao
PURPOSE: To develop a model for studying cerebrovascular disease prevention in elderly women. METHODS: Sixty 18-month-old Sprague Dawley (SD) rats were randomly divided into an estrogen administration group (EA, n=30) and a non-administration group (NA, n=30); thirty 4-month-old SD rats were allocated to a control group. The EA group received estradiol benzoate starting on the 5th day of a 34-day breeding period, and the serum levels of estradiol (E2), estrogen receptor (ER), and malondialdehyde (MDA) were measured...
October 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/27824693/aerobic-exercise-training-improves-orthostatic-tolerance-in-aging-humans
#20
Diqun Xu, Hong Wang, Shande Chen, Sarah Ross, Howe Liu, Albert Olivencia-Yurvati, Peter B Raven, Xiangrong Shi
PURPOSE: This study was designed to test the hypothesis that aerobic exercise training of the elderly will increase aerobic fitness without compromising orthostatic tolerance (OT). METHODS: Eight healthy sedentary volunteers (67.0±1.7 years old, 4 women) participated in 1-year of endurance exercise training (stationary bicycle and/or treadmill) program at the individuals' 65%-75% of peak heart rate (HRpeak). Peak O2 uptake (VO2peak) and HRpeak were determined by a maximal exercise stress test using a bicycle ergometer...
November 7, 2016: Medicine and Science in Sports and Exercise
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