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https://www.readbyqxmd.com/read/28816059/atherothrombosis-and-oxidative-stress-mechanisms-and-management-in-elderly
#1
Francesco Violi, Lorenzo Loffredo, Roberto Carnevale, Pasquale Pignatelli, Daniele Pastori
SIGNIFICANCE The incidence of cardiovascular events increases by aging, representing the main cause of death in old population. Aging is associated with over-production of reactive oxygen species (ROS), which may affect clotting and platelet activation, and impair endothelial function so predisposing elderly patients to thrombotic complications. RECENT ADVANCES There are increasing evidences to suggest that aging is associated with an imbalance between oxidative stress and antioxidant status. Thus, up-regulation of ROS-producing enzymes such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and myeloperoxidase, along with down-regulation of antioxidant enzymes, such as superoxide dismutase and glutathione peroxidase, occur during aging...
August 17, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28811228/curcumin-in-alzheimer-s-disease-can-we-think-to-new-strategies-and-perspectives-for-this-molecule
#2
REVIEW
Serafini Melania Maria, Catanzaro Michele, Rosini Michela, Racchi Marco, Lanni Cristina
Population aging is an irreversible global trend with economic and socio-political consequences. One of the most invalidating outcomes of aging in the elderly is cognitive decline, leading to dementia and often related to neurodegenerative disorders. Among these latter, Alzheimer's disease (AD) is the major cause of dementia, affecting more than 30 million of individuals worldwide. To date, the treatment of AD remains a challenge because of an incomplete understanding of the events that lead to the selective neurodegeneration typical of Alzheimer's brains...
August 12, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28805478/production-of-platelet-rich-plasma-gel-from-elderly-patients-under-antithrombotic-drugs-perspectives-in-chronic-wounds-care
#3
M Velier, J Magalon, A Daumas, M Cassar, P Francois, A Ghazouane, C Philandrianos, B Bertrand, C Frere, D Bernot, P Villani, F Dignat George, F Sabatier
Platelet-Rich Plasma (PRP) is an autologous biological therapy obtained by centrifuging the patient's own blood to concentrate platelets. The addition of autologous thrombin and calcium chloride to PRP allows the production of a semi-solid form called PRP gel. PRP gel is increasingly used in a variety of tissue defects and predominantly in the management of non-healing chronic wounds. The topical application of PRP gel seems promising due to the capability of platelets to store and secrete growth factors (GF), fibrin and cytokines, which are essentials for wound healing...
August 14, 2017: Platelets
https://www.readbyqxmd.com/read/28803596/associations-of-baltic-sea-and-mediterranean-dietary-patterns-with-bone-mineral-density-in-elderly-women
#4
Arja T Erkkilä, Homa Sadeghi, Masoud Isanejad, Jaakko Mursu, Marjo Tuppurainen, Heikki Kröger
OBJECTIVE: Dietary quality in relation to bone health has been analysed in relatively few studies. The current study aimed to assess the association of the Baltic Sea diet (BSD) and the Mediterranean diet (MD) with bone mineral density (BMD) among elderly women. DESIGN: Lumbar, femoral and total body BMD were measured by dual-energy X-ray absorptiometry at baseline and year 3. Dietary intake was measured by 3 d food record at baseline. BSD and MD scores were calculated from food and alcohol consumption and nutrient intake...
August 14, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28802215/predictors-of-self-reported-knee-osteoarthritis-in-community-dwelling-older-women-in-japan-a-cross-sectional-and-longitudinal-cohort-study
#5
Narumi Kojima, Miji Kim, Kyoko Saito, Yuko Yoshida, Hirohiko Hirano, Shuichi Obuchi, Hiroyuki Shimada, Takao Suzuki, Hunkyung Kim
PURPOSE: This study aimed to determine the predictors of knee osteoarthritis in community-dwelling elderly Japanese women. METHODS: In this prospective cohort study, The Tokyo Metropolitan Institute of Gerontology collected baseline data in 2008 and follow-up data in 2012 for participants from the Itabashi Ward of Tokyo, Japan. Participants were asked at each time point if they had been diagnosed with knee osteoarthritis. The baseline evaluation was conducted with 1289 community-dwelling women aged 75-85 years, of which 992 reported no history of knee osteoarthritis...
July 30, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28802214/the-relationship-between-physical-activity-meaning-in-life-and-subjective-vitality-in-community-dwelling-older-adults
#6
Haewon Ju
The present study examined the potential contribution of meaning in life to the relationship between physical activity and subjective vitality in older adults. Two-hundred and fifty community-dwelling elders completed the instruments assessing physical activity, meaning in life, and subjective vitality. Results from structural equation modeling indicated that physical activity was positively associated with both meaning in life and subjective vitality. Further, the relationship between physical activity and vitality was partially mediated by meaning in life...
August 2, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28801558/visceral-adiposity-index-lipid-accumulation-product-and-intracranial-atherosclerotic-stenosis-in-middle-aged-and-elderly-chinese
#7
Rui Li, Qi Li, Min Cui, Zegang Ying, Lin Li, Tingting Zhong, Yingchao Huo, Peng Xie
We investigated the association of the newly established lipid accumulation product (LAP) and visceral adiposity index (VAI) with intracranial atherosclerotic stenosis (ICAS) in middle-aged and elderly Chinese. From June 2012 to January 2013, consecutive patients ≥40 years of age who underwent cerebral vascular imaging for various medical reasons were enrolled in this study. Multivariate logistic regression models were used to evaluate the correlation of VAI and LAP with the risk of ICAS. In total, 845 patients were included in the study...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28799293/health-and-aging-policy-fellows-program-shaping-a-healthy-future-for-older-americans
#8
Harold Alan Pincus, Kathleen M Pike, Brigitta Spaeth-Rublee, Lynn Elinson
As the size of the elderly population increases, so do the challenges of and barriers to high-quality, affordable health care. The Health and Aging Policy Fellows (HAPF) Program is designed to provide health and aging professionals with the skills and experience to help lead the effort in reducing these barriers and shaping a healthy and productive future for older Americans. Since its inception in 2008, the program has affected not only the fellows who participate, but also the field of health and aging policy...
August 11, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28799159/-the-japanese-health-care-system-an-analysis-of-the-funding-and-reimbursement-system
#9
Alexis Rump, Oliver Schöffski
Objective The modern Japanese health care system was established during the Meiji period (1868-1912) using the example of Germany. In this paper, the funding and remuneration of health services and products in Japan are described. The focus lies on the mechanisms used to implement health policy goals and to control costs. Method Selective literature search. Results All permanent residents in Japan are enrolled in one of more than 3,000 compulsory health funds. Employees and public servants are covered through company or government-related health insurance schemes...
August 10, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28782621/yongdamsagan-tang-a-traditional-herbal-formula-inhibits-cell-growth-through-the-suppression-of-proliferation-and-inflammation-in-benign-prostatic-hyperplasia-epithelial-1-cells
#10
Eunsook Park, Mee-Young Lee, Chang-Seob Seo, Woo-Young Jeon, Hyeun-Kyoo Shin
ETHNOPHARMACOLOGICAL RELEVANCE: Benign prostatic hyperplasia (BPH), also called benign enlargement of the prostate, is a progressive disease that is observed in most elderly men. Yongdamsagan-tang, a traditional herbal formula, is used commonly for the treatment of inflammation-related diseases. Although the therapeutic efficacy of Yongdamsagan-tang against BPH in vivo was reported previously, its underlying mechanisms are not clearly understood. AIM OF THE STUDY: In this study, we investigated the effect of Yongdamsagan-tang water extract (YSTE) and its mechanism on the growth of human BPH epithelial BPH-1 cells...
August 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28780720/evaluation-of-lactic-acid-bacteria-isolated-from-fermented-plant-products-for-antagonistic-activity-against-urinary-tract-pathogen-staphylococcus-saprophyticus
#11
Cheng-Chih Tsai, Tzu-Min Lai, Pei-Pei Lin, You-Miin Hsieh
Urinary tract infections (UTIs) are the most common infectious diseases in infants and the elderly; they are also the most common among nosocomial infections. The treatment of UTIs usually involves a short-term course of antibiotics. The purpose of this study was to identify the strains of lactic acid bacteria (LAB) that can inhibit the urinary tract pathogen Staphylococcus saprophyticus, as alternatives to antibiotics. In this study, we collected 370 LAB strains from fermented plant products and reference strains from the Bioresources Collection and Research Center (BCRC)...
August 5, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28780196/can-we-reduce-morphine-use-in-elderly-proximal-femoral-fracture-patients-using-a-fascia-iliac-block
#12
Al-Amin M Kassam, Anthony T Gough, Joanna Davies, Rathan Yarlagadda
Proximal femoral fractures are becoming increasingly common with an ageing population. Many patients have multiple comorbidities increasing their risk of opiate complications. 40 consecutive patients presenting with a proximal femoral fracture to a trauma centre in the UK were given either a Fascia Iliaca Block (FIB) with oral analgesia or just oral analgesia to control their pre-operative pain. Numeric pain scores and morphine consumption were used as outcome measures. Patients receiving a FIB had significant reduction in their pain scores compared to patients only receiving oral pain relief...
August 2, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28777750/polymorphonuclear-neutrophil-functions-are-differentially-altered-in-amnestic-mild-cognitive-impairment-and-mild-alzheimer-s-disease-patients
#13
Aurélie Le Page, Julie Lamoureux, Karine Bourgade, Eric H Frost, Graham Pawelec, Jacek M Witkowski, Anis Larbi, Gilles Dupuis, Tamàs Fülöp
The mechanisms of neurodegeneration in Alzheimer's disease (AD) remain under investigations. Alterations in the blood-brain barrier facilitate exchanges of inflammatory mediators and immune cells between the brain and the periphery in AD. Here, we report analysis of phenotype and functions of polymorphonuclear neutrophils (PMN) in peripheral blood in amnestic mild cognitive impairment (aMCI, n = 13), patients with mild AD (mAD, n = 15), and healthy elderly controls (n = 13). Results showed an increased expression of CD177 in mAD but not in healthy or aMCI patients...
July 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28777210/rapamycin-prolongs-graft-survival-and-induces-cd4-ifn-%C3%AE-il-10-regulatory-type-1-cells-in-old-recipient-mice
#14
Markus Quante, Timm Heinbokel, Karoline Edtinger, Koichiro Minami, Hirofumi Uehara, Yeqi Nian, Haruhito Azuma, Reza Abdi, Abdallah Elkhal, Stefan G Tullius
BACKGROUND: Although the elderly represents a rapidly growing population among transplant recipients, age-specific aspects have not been considered sufficiently in clinical trials. Moreover, age-specific effects of immunosuppressive therapies remain poorly understood. METHODS: Here, we assessed the impact of Rapamycin on alloimmune responses in old recipients using a fully MHC-mismatched murine transplantation model. RESULTS: Old untreated recipients displayed a prolonged skin graft survival compared to their young counterparts, an observation that confirmed data of our previous experiments...
August 2, 2017: Transplantation
https://www.readbyqxmd.com/read/28774959/what-is-the-ethics-of-ageing
#15
Christopher Simon Wareham
Applied ethics is home to numerous productive subfields such as procreative ethics, intergenerational ethics and environmental ethics. By contrast, there is far less ethical work on ageing, and there is no boundary work that attempts to set the scope for 'ageing ethics' or the 'ethics of ageing'. Yet ageing is a fundamental aspect of life; arguably even more fundamental and ubiquitous than procreation. To remedy this situation, I examine conceptions of what the ethics of ageing might mean and argue that these conceptions fail to capture the requirements of the desired subfield...
August 3, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28768749/orientation-of-native-versus-translocated-juvenile-lesser-spotted-eagles-clanga-pomarina-on-the-first-autumn-migration
#16
Bernd-U Meyburg, Ugis Bergmanis, Torsten Langgemach, Kai Graszynski, Arno Hinz, Ingo Börner, Christiane Meyburg, Wouter M G Vansteelant
The ontogeny of migration routines used by wild birds remains unresolved. Here we investigated the migratory orientation of juvenile lesser spotted eagles (LSE; Clanga pomarina) based on translocation and satellite tracking. Between 2004 and 2016, 85 second-hatched juveniles (Abels) were reared in captivity for release into the declining German population, including 50 birds that were translocated 940 km from Latvia. In 2009, we tracked 12 translocated juveniles, as well as eight native juveniles and nine native adults, to determine how inexperienced birds come to use strategic migration routes...
August 1, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28768257/autoimmunity-in-the-elderly-insights-from-basic-science-and-clinics-a-mini-review
#17
Abdulla Watad, Nicola Luigi Bragazzi, Mohammad Adawi, Howard Amital, Elias Toubi, Bat-Sheva Porat, Yehuda Shoenfeld
Advancements in the field of biomedicine, including the control of infectious diseases through antibiotics and vaccination practices and the prevention of chronic disorders, have led to reduced mortality, increased life expectancy and, as such, growth of the older population. Ageing is accompanied by profound morphological and physiological alterations. In particular, the immune system undergoes a complex series of remodeling/restructuring events, involving almost all compartments - both the innate and the adaptive system...
July 29, 2017: Gerontology
https://www.readbyqxmd.com/read/28766750/using-food-comfortability-to-compare-food-s-sensory-characteristics-expectations-of-elderly-people-with-or-without-oral-health-problems
#18
Mathilde Vandenberghe-Descamps, Claire Sulmont-Rossé, Chantal Septier, Gilles Feron, Hélène Labouré
Food consumption is by far the most important point where food's organoleptic properties can be perceived and can elicit sensory pleasure. Ageing is often accompanied by oral impairments. Those impairments may impact food perception by changing texture perception and the release of flavor components, which have a significant impact on food acceptability. The present study aimed at evaluating the impact of oral health on the perception of food comfortability in an elderly population. This was achieved by asking elderly people with a good oral health and elderly people with poor oral health to rate six cereal products and six meat products using a food comfortability questionnaire...
August 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28764696/healthcare-quality-improvement-and-work-engagement-concluding-results-from-a-national-longitudinal-cross-sectional-study-of-the-productive-ward-releasing-time-to-care-programme
#19
Mark White, Tony Butterworth, John Sg Wells
BACKGROUND: Concerns about patient safety and reducing harm have led to a particular focus on initiatives that improve healthcare quality. However Quality Improvement (QI) initiatives have in the past typically faltered because they fail to fully engage healthcare professionals, resulting in apathy and resistance amongst this group of key stakeholders. Productive Ward: Releasing Time to Care (PW) is a ward-based QI programme created to help ward-based teams redesign and streamline the way that they work; leaving more time to care for patients...
August 1, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28760432/elderly-patients-on-hemodialysis-have-worse-dietary-quality-and-higher-consumption-of-ultraprocessed-food-than-elderly-without-chronic-kidney-disease
#20
Aline Moutinho Martins, Annie Seixas Bello Moreira, Daniela Silva Canella, Juliana Rodrigues, Fernanda Santin, Brenda Wanderley, Roberto Alves Lourenço, Carla Maria Avesani
OBJECTIVES: The multiple dietary restrictions recommended to patients on hemodialysis (HD), coupled with conditions imposed by aging, may lead to poor dietary quality in these patients. The aim of this study was to investigate the dietary quality and consumption of ultraprocessed food by elderly patients on HD and those without chronic kidney disease (CKD). Additionally, diets on the day of dialysis and on nondialysis days were evaluated. METHODS: This was a cross-sectional study conducted with 153 noninstitutionalized elderly patients on HD (Elder-HD) and 47 non-CKD elderly (Elder-Healthy) aged ≥60 y...
September 2017: Nutrition
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