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https://www.readbyqxmd.com/read/28743126/frontal-cortex-and-hippocampal-%C3%AE-secretase-activating-protein-levels-in-prodromal-alzheimer-disease
#1
Sylvia E Perez, Muhammad Nadeem, Michael H Malek-Ahmadi, Bin He, Elliott J Mufson
BACKGROUND: β-Amyloid (Aβ) is the product of concerted cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. However, the molecular mechanisms that regulate this process are not well understood. Recently, evidence was reported that γ-secretase activating protein (GSAP, 16 kDa), derived from a larger precursor protein (98 kDa), plays a role in Aβ metabolism through a mechanism involving its interaction with both γ-secretase and APP. However, a detailed evaluation of GSAP protein levels and their association with clinical and neuropathological variables are lacking during the clinical progression of Alzheimer disease (AD)...
July 26, 2017: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/28743108/high-density-lipoprotein-cholesterol-level-relates-to-working-memory-immediate-and-delayed-cued-recall-in-brazilian-older-adults-the-role-of-cognitive-reserve
#2
Andreas Ihle, Élvio R Gouveia, Bruna R Gouveia, Duarte L Freitas, Jefferson Jurema, Maria A Tinôco, Matthias Kliegel
AIMS: The present study set out to investigate the relation of the high-density lipoprotein cholesterol (HDL-C) level to cognitive performance and its interplay with key markers of cognitive reserve in a large sample of older adults. METHODS: We assessed tests of working memory, immediate and delayed cued recall in 701 older adults from Amazonas, Brazil. The HDL-C level was derived from fasting blood samples. In addition, we interviewed individuals on their education, past occupation, and cognitive leisure activity...
July 26, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28743056/apigenin-attenuates-isoflurane-induced-cognitive-dysfunction-via-epigenetic-regulation-and-neuroinflammation-in-aged-rats
#3
Lin Chen, Wenji Xie, Wenqin Xie, Weiqiang Zhuang, Changcheng Jiang, Naizhen Liu
PURPOSE OF THE RESEARCH: Post operational cognitive dysfunction (POCD) occurs in patients after anesthesia and surgery. Abnormal histone acetylation and neuroinflammation are key factors in the pathogenesis of cognitive impairment. Apigenin not only has an anti-inflammatory activity but also modifies histone acetylation. We aimed to investigate whether apigenin can attenuate isoflurane exposure-induced cognitive decline by regulating histone acetylation and inflammatory signaling. MATERIALS AND METHODS: Spatial learning and memory were assessed by Morris water maze test...
July 6, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28742932/a-pilot-randomized-clinical-trial-testing-integrated-twelve-step-facilitation-itsf-treatment-for-adolescent-substance-use-disorder
#4
John F Kelly, Yifrah Kaminer, Christopher W Kahler, Bettina Hoeppner, Julie Yeterian, Julie V Cristello, Christine Timko
BACKGROUND AND AIMS: Integration of 12-step philosophy and practices is common in adolescent substance use disorder (SUD) treatment programs, particularly in North America. However, although numerous experimental studies have tested 12-step facilitation (TSF) treatments among adults, no studies have tested TSF-specific treatments for adolescents. We tested the efficacy of a novel integrated TSF. DESIGN: Explanatory, parallel-group, randomized clinical trial comparing 10 sessions of either motivational enhancement therapy/cognitive-behavioral therapy (MET/CBT; n=30) or a novel integrated TSF (iTSF; n=29) with follow-up assessments at 3-, 6-, and 9-months following treatment entry...
July 25, 2017: Addiction
https://www.readbyqxmd.com/read/28742612/short-sleep-and-adolescents-performance-on-a-concussion-assessment-battery-an-experimental-sleep-manipulation-study
#5
Dean W Beebe, Scott W Powers, Eric W Slattery, Paul J Gubanich
OBJECTIVE: Correlational studies have linked short sleep to adolescents' report of postconcussion symptoms and cognitive performance during concussion assessments. This study tested whether those are cause-effect relationships. DESIGN: Three-week randomly counterbalanced, within-subjects, crossover experiment. SETTING: Adolescents slept at home with weekly visits to an outpatient clinic for sleep monitor uploads and outcome assessments. PARTICIPANTS: Twenty-four healthy 14- to 17...
July 21, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28742507/severe-neurological-abnormalities-in-a-young-boy-with-impaired-thyroid-hormone-sensitivity-due-to-a-novel-mutation-in-the-mct8-gene
#6
Teresa Rego, Carmen Gomez Lado, Paloma Cabanas Rodríguez, Francisco Sousa Santos, Francisco Barros Angueira, Lidia Castro-Feijóo, Jesús Barreiro Conde, Manuel Castro-Gago
Monocarboxylate transporter 8 (MCT8) is an active and specific thyroid hormone transporter into neurons. MCT8 mutations cause an X-linked condition known as Allan-Herndon-Dudley syndrome and are characterized by impaired psychomotor development and typical abnormal thyroid function. We describe a 10-year-old boy with severe cognitive disability, axial hypotonia, spastic quadriplegia and sporadic dyskinetic episodes. He initially presented with thyroid dysfunction (high FT3, low rT3, low FT4 and normal TSH) and generalized retardation of the cerebral and cerebellar myelination in brain magnetic resonance imaging...
April 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28742136/can-a-tablet-based-cancellation-test-identify-cognitive-impairment-in-older-adults
#7
Ya-Huei Wu, Jean-Sébastien Vidal, Jocelyne de Rotrou, Sietske A M Sikkes, Anne-Sophie Rigaud, Matthieu Plichart
BACKGROUND AND OBJECTIVE: There has been a growing interest in using computerized cognitive assessment to detect age-related cognitive disorders. We have developed a tablet-based cancellation test (e-CT), previously shown as a reliable measure of executive functions and free of effect of familiarity with computer-based devices in healthy older adults. This study aimed to investigate the influence of demographics and current daily use of computer-based devices in older adults with Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD)...
2017: PloS One
https://www.readbyqxmd.com/read/28741982/multimodal-mr-imaging-signatures-of-cognitive-impairment-in-active-professional-fighters
#8
Virendra R Mishra, Xiaowei Zhuang, Karthik R Sreenivasan, Sarah J Banks, Zhengshi Yang, Charles Bernick, Dietmar Cordes
Purpose To investigate whether combining multiple magnetic resonance (MR) imaging modalities such as T1-weighted and diffusion-weighted MR imaging could reveal imaging biomarkers associated with cognition in active professional fighters. Materials and Methods Active professional fighters (n = 297; 24 women and 273 men) were recruited at one center. Sixty-two fighters (six women and 56 men) returned for a follow-up examination. Only men were included in the main analysis of the study. On the basis of computerized testing, fighters were separated into the cognitively impaired and nonimpaired groups on the basis of computerized testing...
July 25, 2017: Radiology
https://www.readbyqxmd.com/read/28741736/increased-mindfulness-skills-as-predictors-of-reduced-trauma-related-guilt-in-treatment-seeking-veterans
#9
Philip Held, Gina P Owens, J Richard Monroe, Kathleen M Chard
The present study examined the predictive role of increased self-reported mindfulness skills on reduced trauma-related guilt in a sample of veterans over the course of residential treatment for posttraumatic stress disorder (PTSD; N = 128). The residential treatment consisted of seven weeks of intensive cognitive processing therapy (CPT) for PTSD, as well as additional psychoeducational groups, including seven sessions on mindfulness skills. Increased mindfulness skills describing, acting with awareness, and accepting without judgment were significantly associated with reductions in trauma-related guilt over the course of treatment...
July 25, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28741702/automatic-thoughts-as-a-predictor-of-internalizing-and-externalizing-problems-in-chinese-adolescents-a-test-of-the-cognitive-content-specificity-hypothesis-with-age-effects
#10
Meng Yu, Wei Xu, Qiuyuan Xie, Yawen Zhu, Gregory S Chasson, Jianping Wang
The main aim of the current study was to test the cognitive content-specificity hypothesis across internalizing and externalizing problems in Chinese adolescents. The participants consisted of 2,158 adolescents aged 11-19 years from three middle schools, and they completed a number of measures assessing a wide range of automatic thoughts and syndromes related to internalizing and externalizing problems. Multivariate regression analyses demonstrated that thoughts about social threats, personal failure and hostility were the strongest predictors of anxiety, depression, and externalizing problems, respectively...
July 25, 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/28741593/electro-cutaneous-stimulation-on-the-palm-elicits-referred-sensations-on-intact-but-not-on-amputated-digits
#11
Marco D'Alonzo, Leonard Frederik Engels, Marco Controzzi, Christian Cipriani
Objective Grasping and manipulation control critically depends on tactile feedback. Without this feedback, the ability for fine control of a prosthesis is limited in upper limb amputees. Early studies have shown that non-invasive electro-cutaneous stimulation (ES) can induce referred sensations that are spread to a wider and/or more distant area, with respect to the electrodes. Building on this, we sought to exploit this effect to provide somatotopically matched sensory feedback to people with partial hand (digital) amputations...
July 25, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28741437/traumatic-brain-injury-in-a-community-based-cohort-of-homeless-and-vulnerably-housed-individuals
#12
Toby Schmitt, Allen Thornton, Iris Rawtaer, Alasdair Barr, Kristina Gicas, Donna Lang, Talia Vertinsky, Alexander Rauscher, Ric Procyshyn, Tari Buchanan, Alex Cheng, Sarah Mackay, Olga Leonova, Verena Langheimer, Thalia Field, Manraj K S Heran, Fidel Vila-Rodriguez, Tiffany-Anne O'Connor, William MacEwan, William Honer, William Panenka
We characterized traumatic brain injury (TBI) and studied its associations with mental and physical health in a community cohort of homeless and vulnerably-housed individuals. METHODS: Detailed mental and physical health structured interviews, neuropsychological testing, and multimodal MRI were performed on 283 participants. Two traumatic brain injury (TBI) participant groups were defined for primary analyses: those with a self-reported history of TBI and those with MRI evidence of TBI...
July 25, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28741373/adaptation-and-validation-into-portuguese-language-of-the-six-item-cognitive-impairment-test-6cit
#13
João Luís Alves Apóstolo, Diana Dos Santos Paiva, Rosa Carla Gomes da Silva, Eduardo José Ferreira Dos Santos, Timothy John Schultz
BACKGROUND: The six-item cognitive impairment test (6CIT) is a brief cognitive screening tool that can be administered to older people in 2-3 min. OBJECTIVE: To adapt the 6CIT for the European Portuguese and determine its psychometric properties based on a sample recruited from several contexts (nursing homes; universities for older people; day centres; primary health care units). METHOD: The original 6CIT was translated into Portuguese and the draft Portuguese version (6CIT-P) was back-translated and piloted...
July 25, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28741230/new-therapeutic-strategies-for-lewy-body-dementias
#14
REVIEW
Latha Velayudhan, Dominic Ffytche, Clive Ballard, Dag Aarsland
This article reviews current treatment strategies and recent advances for the Lewy body dementias (LBDs). Current available symptom treatment strategies are based on monoaminergic, cholinergic and glutaminergic neurotransmitter systems. Relatively robust evidence exists for cholinesterase inhibitors for cognitive impairment in LBD and in Parkinson's disease for antidepressants, clozapine and recently pimavanserin for psychosis. interpidine (RVT 101) and nelotanserin are currently under investigation. Non-pharmacological interventions, such as cognitive stimulation, physical exercises and neuromodulation strategies, may be useful in Parkinson's disease but have not yet been tested in dementias...
September 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28741045/erratum-to-assessment-of-individual-cognitive-changes-after-deep-brain-stimulation-surgery-in-parkinson-s-disease-using-the-neuropsychological-test-battery-vienna-short-version
#15
Thomas Foki, Daniela Hitzl, Walter Pirker, Klaus Novak, Gisela Pusswald, Eduard Auff, Johann Lehrner
No abstract text is available yet for this article.
July 24, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28741028/transfer-of-time-based-task-expectancy-across-different-timing-environments
#16
Stefanie Aufschnaiter, Andrea Kiesel, Roland Thomaschke
Recent research on time-based expectancy has shown that humans base their expectancies for responses on representations of temporal relations (e.g., shorter vs. longer duration), rather than on representations of absolute durations (e.g., 500 vs. 1000 ms). In the present study, we investigated whether this holds also true for time-based expectancy of tasks instead of responses. Using a combination of the time-event correlation paradigm and the standard task-switching paradigm, participants learned to associate two different time intervals with two different tasks in a learning phase...
July 24, 2017: Psychological Research
https://www.readbyqxmd.com/read/28740826/epicog-sch-a-brief-battery-to-screen-cognitive-impact-of-schizophrenia-in-stable-outpatients
#17
Silvia Zaragoza Domingo, Julio Bobes, Maria-Paz García-Portilla, Claudia Morralla
Brief batteries in schizophrenia, are needed to screen for the cognitive impact of schizophrenia. We aimed to validate and co-norm the Epidemiological Study of Cognitive Impairment in Schizophrenia (EPICOG-SCH) derived brief cognitive battery. A cross-sectional outpatient evaluation was conducted of six-hundred-seventy-two patients recruited from 234 centers. The brief battery included well-known subtests available worldwide that cover cognitive domains related to functional outcomes: WAIS-III-Letter-Number-Sequencing-LNS, Category Fluency Test-CFT, Logical-Memory Immediate Recall-LM, and Digit-Symbol-Coding-DSC...
June 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740824/associations-between-daily-living-skills-cognition-and-real-world-functioning-across-stages-of-schizophrenia-a-study-with-the-schizophrenia-cognition-rating-scale-japanese-version
#18
Yuko Higuchi, Tomiki Sumiyoshi, Tomonori Seo, Motomu Suga, Tsutomu Takahashi, Shimako Nishiyama, Yuko Komori, Kiyoto Kasai, Michio Suzuki
Cognitive function is impaired in patients with schizophrenia-spectrum disorders, even in their prodromal stages. Specifically, the assessment of cognitive abilities related to daily-living functioning, or functional capacity, is important to predict long-term outcome. In this study, we sought to determine the validity of the Schizophrenia Cognition Rating Scale (SCoRS) Japanese version, an interview-based measure of cognition relevant to functional capacity (i.e. co-primary measure). For this purpose, we examined the relationship of SCoRS scores with performance on the Brief Assessment of Cognition in Schizophrenia (BACS) Japanese version, a standard neuropsychological test battery, and the Social and Occupational Functioning Assessment Scale (SOFAS), an interview-based social function scale...
March 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740821/validating-the-construct-of-aberrant-salience-in-schizophrenia-behavioral-evidence-for-an-automatic-process
#19
Teresa Katthagen, Felix Dammering, Norbert Kathmann, Jakob Kaminski, Henrik Walter, Andreas Heinz, Florian Schlagenhauf
Suspecting significance behind ordinary events is a common feature in psychosis and it is assumed to occur due to aberrant salience attribution. The Salience Attribution Test (SAT; Roiser et al., 2009) measures aberrant salience as a bias towards one out of two equally reinforced cue features as opposed to adaptive salience towards features indicating high reinforcement. This is the first study to validate the latent constructs involved in salience attribution in patients. Forty-nine schizophrenia patients and forty-four healthy individuals completed the SAT, a novel implicit salience paradigm (ISP), a reversal learning task and a neuropsychological test battery...
December 2016: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740818/disrupted-latent-inhibition-in-individuals-at-ultra-high-risk-for-developing-psychosis
#20
Michael Kraus, Attilio Rapisarda, Max Lam, Jamie Y J Thong, Jimmy Lee, Mythily Subramaniam, Simon L Collinson, Siow Ann Chong, Richard S E Keefe
The addition of off-the-shelf cognitive measures to established prodromal criteria has resulted in limited improvement in the prediction of conversion to psychosis. Tests that assess cognitive processes central to schizophrenia might better identify those at highest risk. The latent inhibition paradigm assesses a subject's tendency to ignore irrelevant stimuli, a process integral to healthy perceptual and cognitive function that has been hypothesized to be a key deficit underlying the development of schizophrenia...
December 2016: Schizophrenia Research. Cognition
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