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https://www.readbyqxmd.com/read/29224108/negative-impact-of-testosterone-deficiency-and-5%C3%AE-reductase-inhibitors-therapy-on-metabolic-and-sexual-function-in-men
#1
Abdulmaged M Traish
Androgens are steroid hormones with pleotropic and diverse biochemical and physiological functions, and androgen deficiency exerts a negative impact on human health. Testosterone (T) either directly or via its transformation into the more potent metabolite 5α-dihydrotestosterone (5α-DHT) or via aromatization into estradiol (E2) modulates important biochemical signaling pathways of human physiology and plays a critical role in the growth and/or maintenance of functions in a host of tissues and organs. T and 5α-DHT play an important role in regulating physiology of the muscle, adipose tissue, liver, bone, and central nervous system, as well as reproductive and sexual functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29223915/marijuana-buyers-in-the-united-states-2010-2014
#2
Alejandro Azofeifa, Laura J Sherman, Margaret E Mattson, Rosalie L Pacula
BACKGROUND: Obtaining or purchasing marijuana in the U.S. can be done only in certain states via a lawful market, for medical or non-medical (recreational) purposes, or via an unlawful market ("black market") by home cultivation and unlicensed vendors and individuals. Given the evolving U.S. state marijuana legislation landscape, the objective of this study is to describe individuals who report buying marijuana in the past year by selected characteristics and U.S. geographical location...
December 5, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29223899/nighttime-nox-loss-and-clno2-formation-in-the-residual-layer-of-a-polluted-region-insights-from-field-measurements-and-an-iterative-box-model
#3
Hui Yun, Tao Wang, Weihao Wang, Yee Jun Tham, Qinyi Li, Zhe Wang, Steven C N Poon
The heterogeneous reaction of dinitrogen pentoxide (N2O5) on aerosols is an important sink of nitrogen oxides (NOx) in the polluted boundary layer, and the production of nitryl chloride (ClNO2) can have significant effects on the atmospheric oxidative capacity. However, the heterogeneous loss of N2O5 and the formation of ClNO2 are still not well quantified, especially in China. In a previous study, we measured ClNO2 and N2O5 concentrations in several air masses at a high-elevation site in Hong Kong, and found the highest levels ever reported at one night...
December 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223800/total-and-differential-white-blood-cell-counts-and-hemodynamic-parameters-in-first-episode-psychosis
#4
Grant Moody, Brian J Miller
There is evidence for blood inflammatory abnormalities in patients with first-episode psychosis (FEP). The monocyte- and neutrophil-to-lymphocyte ratios (MLR; NLR) are markers of inflammation and endothelial dysfunction, and predictors of cardiovascular disease, the leading cause of death in schizophrenia. We investigated relationships between white blood cell (WBC) counts and hemodynamic parameters associated with cardiovascular disease risk in 25 subjects age 18-50 hospitalized for FEP and 44 controls. Subjects had a blood draw, vital signs, and medical history...
December 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29223731/permeability-of-expander-breast-implants-in-vitro-and-in-vivo-analyses
#5
Lionel Tortolano, Stéphanie Yen-Nicolaÿ, Pierre-François Rogliano, Heba Alkhashnam, Jean-François Honart, Katia Manerlax, Françoise Rimareix, François Lemare, Najet Yagoubi
INTRODUCTION: The biocompatibility of the polysiloxane breast implant has been studied moderately. The aging of these implants due to lipid penetration and the release of polymerization impurities, such as Platine or octamethylcyclotetrasiloxane (named D4), has already been documented. Since these studies, manufacturing procedures have been improved; thus, the security of breast implants has also improved. Although polymerization and the choice of monomer influence the shell properties, few studies have compared these together in breast implants...
December 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29223674/prediction-of-need-for-intervention-in-posterior-urethral-valves-use-of-urine-osmolality
#6
Anna E Wright, Ruth Wragg, Joana Lopes, Andrew Robb, Liam McCarthy
AIM: Renal tubular dysfunction (RTD) causing obligate production of hypoosmolar urine in boys with posterior urethral valves (PUVs) has been described. It is not known how clinically significant this is. We hypothesize that a feedback loop is present in many PUV boys who suffer deterioration of their lower urinary tract (LUT). RTD results in hypoosmolar urine, obligate polyuria, and bladder stretch-injury. The increasing back-pressure worsens RTD, thus exacerbating the injury. Coexisting renal dysplasia and acquired renal scarring exacerbate this...
November 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29223488/oral-administration-of-plga-encapsulated-cpg-odn-and-campylobacter-jejuni-lysate-reduces-cecal-colonization-by-campylobacter-jejuni-in-chickens
#7
Khaled Taha-Abdelaziz, Douglas C Hodgins, Tamiru Negash Alkie, Wanderely Quinteiro-Filho, Alexander Yitbarek, Jake Astill, Shayan Sharif
Campylobacter jejuni (C. jejuni) is a major cause of bacterial food-borne illness in humans. It is considered a commensal organism of the chicken gut and infected chickens serve as a reservoir and shed bacteria throughout their lifespan. Contaminated poultry products are considered the major source of infection in humans. Therefore, to reduce the risk of human campylobacteriosis, it is essential to reduce the bacterial load in poultry products. The present study aimed to evaluate the protective effects of soluble and PLGA-encapsulated oligodeoxynucleotides (ODN) containing unmethylated CpG motifs (E-CpG ODN) as well as C...
December 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29223351/ck2%C3%AE-promotes-advanced-glycation-end-products-induced-expressions-of-fibronectin-and-intercellular-adhesion-molecule-1-via-activating-mrtf-a-in-glomerular-mesangial-cells
#8
Zhiquan Chen, Qiuhong Chen, Junying Huang, Wenyan Gong, Yezi Zou, Lei Zhang, Peiqing Liu, Heqing Huang
Advanced glycation end products (AGEs) modification of extracellular matrix proteins induces crosslinking, which results in thickening of the basement membrane and activating several intracellular signaling cascades, eventually promoting the pathological progression of diabetic nephropathy (DN). We have previously confirmed that casein kinase 2α (CK2α) activates the nuclear factor of kappaB (NF-κB) signaling pathway to enhance high glucose-induced expressions of fibronectin (FN) and intercellular adhesion molecule-1 (ICAM-1) in glomerular mesangial cells (GMCs)...
December 6, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29223187/children-s-comprehension-of-contrastive-connectives
#9
Jennifer Spenader
Production studies show connective acquisition by age 3;0, but comprehension studies show errors until 9;0 or older. To further investigate this gap, two comprehension tasks were carried out with 78 Dutch children between the ages of 7;0 and 10;1, testing contrastive maar 'but' and causal want 'because' connectives for comparison. An existing context choice task and a task that tested children's ability to interpret pronouns dependent on the connective were used. Children did well on the context choice task for want 'because', but performed far below chance with maar 'but'...
December 10, 2017: Journal of Child Language
https://www.readbyqxmd.com/read/29223138/plant-expressed-fc-fusion-protein-tetravalent-dengue-vaccine-with-inherent-adjuvant-properties
#10
Mi Young Kim, Alastair Copland, Kaustuv Nayak, Anmol Chandele, Muhammad Shamsher Ahmed, Qibo Zhang, Gil Reynolds Diogo, Matthew John Paul, Sven Hofmann, Moon-Sik Yang, Yong-Suk Jang, Julian K-C Ma, Rajko Reljic
Dengue is a major global disease requiring improved treatment and prevention strategies. The recently licensed Sanofi-Pasteur Denvaxia vaccine does not protect children under the age of nine and additional vaccine strategies are thus needed to halt this expanding global epidemic. Here, we employed a molecular engineering approach and plant-expression to produce a humanised and highly immunogenic Poly-Immunoglobulin G Scaffold (PIGS) fused to the consensus dengue envelope protein III domain (cEDIII). The immunogenicity of this IgG Fc receptor targeted vaccine candidate was demonstrated in transgenic mice expressing human FcγRI/CD64, by induction of neutralising antibodies and evidence of cell-mediated immunity...
December 9, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29223112/development-of-the-handwriting-legibility-scale-hls-a-preliminary-examination-of-reliability-and-validity
#11
Anna L Barnett, Mellissa Prunty, Sara Rosenblum
BACKGROUND: Demands for the production of legible handwriting produced in a timely manner increase as children progress through school. Despite the considerable number of children faced with handwriting difficulties, there is no quick and practical tool to assess legibility in this population. AIM: The aim of this study was to develop the Handwriting Legibility Scale (HLS) and to establish the scale's reliability and validity. METHODS: The HLS is a non-language dependent scale which assesses global legibility, based on five criteria applied to samples of 'free writing'...
December 6, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29222945/children-with-atopic-dermatitis-may-have-unacknowledged-contact-allergies-contributing-to-their-skin-symptoms
#12
Anne Birgitte Simonsen, Jeanne Duus Johansen, Mette Deleuran, Charlotte Gotthard Mortz, Lone Skov, Mette Sommerlund
BACKGROUND: Whether children with atopic dermatitis have an altered risk of contact allergy than children without atopic dermatitis is frequently debated and studies have been conflicting. Theoretically, the impaired skin barrier in AD facilitates the penetration of potential allergens and several authors have highlighted the risk of underestimating and overlooking contact allergy in children with atopic dermatitis. OBJECTIVE: To determine the prevalence of contact allergy in Danish children with atopic dermatitis and explore the problem of unacknowledged allergies maintaining or aggravating the skin symptoms...
December 9, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29222892/benefit-of-oral-nutritional-supplements-for-children-with-acute-lymphoblastic-leukaemia-during-remission-induction-chemotherapy-a-quasi-experimental-study
#13
Rui Liang, Gai-Yun Chen, San-Xian Fu, Jie Zhong, Yan Ma
BACKGROUND AND OBJECTIVES: To determine the effect of oral nutritional supplements (ONS) on children with acute lymphoblastic leukaemia undergoing remission-induction chemotherapy. METHODS AND STUDY DESIGN: We included 127 paediatric patients who were diagnosed with acute lymphoblastic leukaemia and undergoing remission- induction chemotherapy in the First Affiliated Hospital of Zhengzhou University. Children from two paediatric wards who met the inclusion criteria were enrolled...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222557/accentuate-the-negative-grammatical-errors-during-narrative-production-as-a-clinical-marker-of-central-nervous-system-abnormality-in-school-aged-children-with-fetal-alcohol-spectrum-disorders
#14
John C Thorne
Purpose: The purpose of this study was to examine (a) whether increased grammatical error rates during a standardized narrative task are a more clinically useful marker of central nervous system abnormality in Fetal Alcohol Spectrum Disorders (FASD) than common measures of productivity or grammatical complexity and (b) whether combining the rate of grammatical errors with the rate of cohesive referencing errors can improve utility of a standardized narrative assessment task for FASD diagnosis...
December 8, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29222392/case-control-study-to-assess-the-association-between-colorectal-cancer-and-selected-occupational-agents-using-interocc-job-exposure-matrix
#15
Sonia El-Zaemey, T N Anand, Jane Shirley Heyworth, Terry Boyle, Martie van Tongeren, Lin Fritschi
BACKGROUND: Colorectal cancer is the third most prevalent cancer in the world and is twice as common in developed countries when compared with low-income and middle-income countries. Few occupational risk factors for colorectal cancer have been identified. This case-control study aimed to assess the association between colorectal cancer and occupational exposure to selected solvents, combustion products, metals, dusts and other agents. METHODS: Cases (n=918) were enrolled from the Western Australian Cancer Registry from June 2005 to August 2007...
December 8, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29222349/inequity-in-biological-dmard-prescription-for-spondyloarthritis-across-the-globe-results-from-the-asas-comospa-study
#16
Elena Nikiphorou, Désirée van der Heijde, Sam Norton, Robert Bm Landewé, Anna Molto, Maxime Dougados, Filip E Van den Bosch, Sofia Ramiro
OBJECTIVES: The value of biological disease-modifying antirheumatic drugs (bDMARDs) in spondyloarthritis (SpA) is well recognised, but global access to these treatments can be limited due to high costs and other factors. This study explores country variation in the use of bDMARDs in SpA in relation to country-level socioeconomic factors. METHODS: Patients fulfilling the Assessment in SpondyloArthritis International Society (ASAS) SpA criteria in the multinational, cross-sectional ASAS Comorbidities in Spondyloarthritis study were studied...
December 8, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29222308/hemophilia-gene-therapy-comes-of-age
#17
REVIEW
Lindsey A George
Concurrent with the development of recombinant factor replacement products, the characterization of the F9 and F8 genes over 3 decades ago allowed for the development of recombinant factor products and made the hemophilias a target disease for gene transfer. The progress of hemophilia gene therapy has been announced in 3 American Society of Hematology scientific plenary sessions, including the first "cure" in a large animal model of hemophilia B in 1998, first in human sustained vector-derived factor IX activity in 2011, and our clinical trial results reporting sustained vector-derived factor IX activity well into the mild or normal range in 2016...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222239/aging-hematopoiesis-and-the-myelodysplastic-syndromes
#18
REVIEW
Stephen S Chung, Christopher Y Park
The aging hematopoietic system undergoes numerous changes, including reduced production of red blood cells and lymphocytes as well as a relative increase in the production of myeloid cells. Emerging evidence indicates that many of these changes are due to selection pressures from cell-intrinsic and cell-extrinsic factors that result in clonal shifts in the hematopoietic stem cell (HSC) pool, resulting in predominant HSC clones that exhibit the functional characteristics associated with HSC aging. Given the recent descriptions of clonal hematopoiesis in aged populations, the increased risk of developing hematologic malignancies in individuals with clonal hematopoiesis, and the many similarities in hematopoietic aging and acquired bone marrow failure (BMF) syndromes, such as myelodysplastic syndromes (MDS), this raises significant questions regarding the relationship between aging hematopoiesis and MDS, including the factors that regulate HSC aging, whether clonal hematopoiesis is required for the development of MDS, and even whether BMF is an inevitable consequence of aging...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222012/macrophage-immunomodulatory-activity-of-the-polysaccharide-isolated-from-collybia-radicata-mushroom
#19
Yufeng Wang, Youqiu Tian, Jiangjuan Shao, Xu Shu, Jinxia Jia, Xiaojie Ren, Yue Guan
Polysaccharides from Collybia radicata mushroom (CRP) possess many functions, such as antiviral, anti-aging and hypolipidemic activities. However, little is known about their immunomodulatory activity. To address this issue, we did a thorough research into their immune effects on murine macrophages. The results showed that the 14942Da polysaccharide not only obviously improved the proliferation and phagocytosis of macrophages, but also induced the secretion of nitric oxide (NO), inducible nitric oxide synthase (iNOS) and cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin factors (IL-1β, IL-6 and IL-10)...
December 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29221517/urban-rural-disparity-in-helicobacter-pylori-infection-related-upper-gastrointestinal-cancer-in-china-and-the-decreasing-trend-in-parallel-with-socioeconomic-development-and-urbanization-in-an-endemic-area
#20
Xiaoduo Wen, Denggui Wen, Yi Yang, Yuetong Chen, Guiying Wang, Baoen Shan
BACKGROUND: Globally China has the largest urban-rural disparity in socioeconomic development, and the urban-rural difference in upper gastrointestinal cancer (UGIC) is similar to the difference between developed and developing countries. OBJECTIVES: To describe urban-rural disparity in UGIC and to emphasize prevention by socioeconomic development and urbanization in China. METHODS: Age-standardized incidence rates (ASRs) of cancers in 2012 were compared between urban Shijiazhuang city and rural Shexian County, and trends from 2000-2015 in Shexian County were analyzed...
May 2017: Annals of Global Health
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