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https://www.readbyqxmd.com/read/28103493/individual-educational-attainment-neighborhood-socioeconomic-contexts-and-self-rated-health-of-middle-aged-and-elderly-chinese-exploring-the-mediating-role-of-social-engagement
#1
Wei Zhang, Yan Yan Wu
Analyzing the 2011-2013 China Health and Retirement Longitudinal Study with 14,507 respondents from 393 neighborhoods, and applying generalized linear mixed-effects model, this study examines how individual-level education and neighborhood-socioeconomic contexts affect health through social engagement. Findings reveal that measures of social engagement-social activity and productive activity-are significantly related to self-rated health and partially mediate the effects of individual-level education. Neighborhood-socioeconomic contexts have independent effects on self-rated health beyond individual socio-demographics, and social activity mediates the effects of neighborhood recreational facilities...
January 16, 2017: Health & Place
https://www.readbyqxmd.com/read/28103462/low-adherence-to-mediterranean-diet-in-portugal-pregnant-women-nutrition-in-portugal-and-its-repercussions
#2
REVIEW
Luis Pereira-da-Silva, Elisabete Pinto
INTRODUCTION: Portuguese population is drifting away from the Mediterranean diet-like pattern. In this context, the current nutritionalstatus of women of childbearing age and of pregnant Portuguese women and their growing fetuses is critically reviewed. MATERIAL AND METHODS: A narrative critical review was performed on recent published high quality studies assessing diet and nutritional status of women of childbearing age and pregnant women and its influence on the nutritional status of their offspring...
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28103300/expression-profiling-of-ribosome-biogenesis-factors-reveals-nucleolin-as-a-novel-potential-marker-to-predict-outcome-in-aml-patients
#3
Virginie Marcel, Frédéric Catez, Caroline M Berger, Emeline Perrial, Adriana Plesa, Xavier Thomas, Eve Mattei, Sandrine Hayette, Pierre Saintigny, Philippe Bouvet, Jean-Jacques Diaz, Charles Dumontet
Acute myeloid leukemia (AML) is a heterogeneous disease. Prognosis is mainly influenced by patient age at diagnosis and cytogenetic alterations, two of the main factors currently used in AML patient risk stratification. However, additional criteria are required to improve the current risk classification and better adapt patient care. In neoplastic cells, ribosome biogenesis is increased to sustain the high proliferation rate and ribosome composition is altered to modulate specific gene expression driving tumorigenesis...
2017: PloS One
https://www.readbyqxmd.com/read/28103212/coverage-with-tetanus-diphtheria-and-acellular-pertussis-vaccine-and-influenza-vaccine-among-pregnant-women-minnesota-march-2013-december-2014
#4
Alexandra Barber, Miriam Halstead Muscoplat, Anna Fedorowicz
Pertussis and influenza infections can result in severe disease in infants. The diphtheria, tetanus, acellular pertussis (DTaP) vaccine is recommended for infants beginning at age 2 months, and influenza vaccine is recommended for infants aged ≥6 months. Vaccination of pregnant women induces the production of antibodies that are transferred across the placenta to the fetus and provide passive protection until infants are old enough to receive DTaP and influenza vaccines (1-3). To protect young infants before they are age-eligible for vaccination, the Advisory Committee on Immunization Practices (ACIP) has recommended since 2004 that all women who are or will be pregnant during influenza season receive inactivated influenza vaccine (1), and since 2013 that all pregnant women receive the tetanus, diphtheria, acellular pertussis (Tdap) vaccine (3)...
January 20, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28102966/histone-deacetylase-2-is-decreased-in-peripheral-blood-pro-inflammatory-cd8-t-and-nkt-like-lymphocytes-following-lung-transplant
#5
Greg Hodge, Sandra Hodge, Chien-Li Holmes-Liew, Paul N Reynolds, Mark Holmes
BACKGROUND AND OBJECTIVE: Immunosuppression therapy following lung transplantation fails to prevent chronic rejection in many patients, which is associated with lack of suppression of cytotoxic mediators and pro-inflammatory cytokines in peripheral blood T and natural killer T (NKT)-like cells. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) upregulate/downregulate pro-inflammatory gene expression, respectively; however, differences in the activity of these enzymes following lung transplant are unknown...
February 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28102738/optimization-and-partial-characterization-of-intracellular-anticandidal-protein-from-aspergillus-giganteus-mtcc-8408-using-taguchi-doe
#6
Debashis Dutta, Mira Debnath Das
A new intracellular antifungal protein (afp) production with average molecular weight 24.3 kDa and yield of 0.65 ± 0.1 mg/gram dry cell weight (gdcw) of mycelia in submerged fermentation of Aspergillus giganteus MTCC 8408 was optimized. Taguchi's DOE (design of experiment) L27 orthogonal array (OA) was constructed using Qualitek-4 software with 8 most influensive factors namely, culture pH, temperature, slant age, inoculum volume, agitation and KH2PO4. Scanning electron microscopy (SEM) was used to correlate the effect of selected factors on fungal cell morphology and afp production...
January 19, 2017: Bioengineered
https://www.readbyqxmd.com/read/28102546/ataluren-and-similar-compounds-specific-therapies-for-premature-termination-codon-class-i-mutations-for-cystic-fibrosis
#7
REVIEW
Aisha A Aslam, Colin Higgins, Ian P Sinha, Kevin W Southern
BACKGROUND: Cystic fibrosis is a common life-shortening genetic disorder in the Caucasian population (less common in other ethnic groups) caused by the mutation of a single gene that codes for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein coordinates the transport of salt (and bicarbonate) across cell surfaces and the mutation most notably affects the airways. In the lungs of people with cystic fibrosis, defective protein results in a dehydrated surface liquid and compromised mucociliary clearance...
January 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28102439/reconstruction-of-radionuclide-intakes-for-the-residents-of-east-urals-radioactive-trace-1957-2011
#8
Evgenia I Tolstykh, Lyudmila M Peremyslova, Marina O Degteva, Bruce A Napier
The East Urals Radioactive Trace (EURT) was formed after a chemical explosion in the radioactive waste-storage facility of the Mayak Production Association in 1957 (Southern Urals, Russia) and resulted in an activity dispersion of 7.4 × 10(16) Bq into the atmosphere. Internal exposure due to ingestion of radionuclides with local foodstuffs was the main factor of public exposure at the EURT. The EURT cohort, combining residents of most contaminated settlements, was formed for epidemiological study at the Urals Research Center for Radiation Medicine, Russia (URCRM)...
January 19, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28102204/the-prevalence-of-ctnnb1-mutations-in-primary-aldosteronism-and-consequences-for-clinical-outcomes
#9
Vin-Cent Wu, Shuo-Meng Wang, Shih-Chieh Jeff Chueh, Shao-Yu Yang, Kuo-How Huang, Yen-Hung Lin, Jian-Jhong Wang, Rory Connolly, Ya-Hui Hu, Celso E Gomez-Sanchez, Kang-Yung Peng, Kwan-Dun Wu
Constitutive activation of the Wnt pathway/β-catenin signaling may be important in aldosterone-producing adenoma (APA). However, significant gaps remain in our understanding of the prevalence and clinical outcomes after adrenalectomy in APA patients harboring CTNNB1 mutations. The molecular expression of CYP11B2 and gonadal receptors in adenomas were also explored. Adenomas from 219 APA patients (95 men; 44.2%; aged 50.5 ± 11.9 years) showed a high rate of somatic mutations (n = 128, 58.4%). The majority of them harbored KCNJ5 mutations (n = 116, 52...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101890/g-csf-mobilized-peripheral-blood-stem-cell-collection-for-allogeneic-transplantation-in-healthy-donors-analysis-of-factors-affecting-yield
#10
Maciej Machaczka, Hans Hägglund, Emma Staver, Monika Joks, Moustapha Hassan, Björn Engelbrekt Wahlin, Ulla Axdorph Nygell
Mobilized PBSC are the main source for allogeneic HSCT. We aimed to evaluate factors that affect CD34+ cell yield including the donor's age, gender, BSA, processed blood volume and the method of G-CSF dose calculation. Data from 170 healthy donors were analyzed. The concentration of CD34+ cells in the peripheral blood (PB) and the processed volume of blood were significantly correlated to CD34+ cells yield (P < .00005 and P < .001, respectively). The G-CSF dose per m(2) was significantly correlated to the concentration of CD34+ cells in the PB (P = ...
January 19, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28101123/regulatory-landscape-of-age-rage-oxidative-stress-axis-and-its-modulation-by-ppar%C3%AE-activation-in-high-fructose-diet-induced-metabolic-syndrome
#11
Luca Cannizzaro, Giuseppe Rossoni, Federica Savi, Alessandra Altomare, Cristina Marinello, Thammakorn Saethang, Marina Carini, D Michael Payne, Trairak Pisitkun, Giancarlo Aldini, Asada Leelahavanichkul
BACKGROUND: The AGE-RAGE-oxidative stress (AROS) axis is involved in the onset and progression of metabolic syndrome induced by a high-fructose diet (HFD). PPARγ activation is known to modulate metabolic syndrome; however a systems-level investigation looking at the protective effects of PPARγ activation as related to the AROS axis has not been performed. The aim of this work is to simultaneously characterize multiple molecular parameters within the AROS axis, using samples taken from different body fluids and tissues of a rat model of HFD-induced metabolic syndrome, in the presence or absence of a PPARγ agonist, Rosiglitazone (RGZ)...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28100787/polymorphic-variants-of-human-protein-l-isoaspartyl-methyltransferase-affect-catalytic-activity-aggregation-and-thermal-stability-implications-for-the-etiology-of-neurological-disorders-and-cognitive-aging
#12
Charity Juang, Baihe Chen, Jean-Louis Bru, Katherine Nguyen, Eric Huynh, Mahsa Momen, Jeungjin Kim, Dana W Aswad
Protein L-isoaspartyl methyltransferase (PIMT/PCMT1), a product of the human pcmt1 gene, catalyzes repair of abnormal L-isoaspartyl linkages in age-damaged proteins. Pcmt1 knockout mice exhibit a profound neuropathology and die 30-60 days postnatal from an epileptic seizure. Here we express 15 reported variants of human PIMT and characterize them with regard to their enzymatic activity, thermal stability, and propensity to aggregation. One mutation, R36C, renders PIMT completely inactive, while two others, A7P and I58V, exhibit activity that is 80-100% higher than wild type...
January 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28100634/cryptochromes-regulate-igf-1-production-and-signaling-through-control-jak2-dependent-stat5b-phosphorylation
#13
Amol Chaudhari, Richa Gupta, Sonal Patel, Nikkhil Velingkaar, Roman Kondratov
Insulin like growth factor (IGF) signaling plays an important role in cell growth and proliferation and implicated in regulation of cancer, metabolism and aging. Here we report that IGF-1 level in blood and IGF-1 signaling demonstrates circadian rhythms. Circadian control occurs through Cryptochromes (CRYs), transcriptional repressors and components of the circadian clock. IGF-1 rhythms are disrupted in Cry deficient mice and IGF-1 level is reduced by 80% in these mice, which leads to reduced IGF signaling...
January 18, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28100604/sufficient-protein-quality-of-food-aid-varies-with-the-physiologic-status-of-recipients
#14
Meghan Callaghan, Momo Oyama, Mark Manary
Protein quality scores use the amino acid (AA) requirements of a healthy North American child. AA requirements vary with physiologic status. We estimated AA requirements for healthy North American children, children with environmental enteric dysfunction, children recovering from wasting, and children with an acute infection. The protein quality of food aid products was then calculated to determine whether it was sufficient in all these groups, and we found that it may not be adequate for all of them. Physiologic status is important when assessing the protein quality of food aid...
January 18, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28100209/lifelong-vegetarianism-and-breast-cancer-risk-a-large-multicentre-case-control-study-in-india
#15
Toral Gathani, Isobel Barnes, Raghib Ali, Rajkumar Arumugham, Raju Chacko, Raghunadharao Digumarti, Parimal Jivarajani, Ravi Kannan, Dasappa Loknatha, Hemant Malhotra, Beela S Mathew
BACKGROUND: The lower incidence of breast cancer in Asian populations where the intake of animal products is lower than that of Western populations has led some to suggest that a vegetarian diet might reduce breast cancer risk. METHODS: Between 2011 and 2014 we conducted a multicentre hospital based case-control study in eight cancer centres in India. Eligible cases were women aged 30-70 years, with newly diagnosed invasive breast cancer (ICD10 C50). Controls were frequency matched to the cases by age and region of residence and chosen from the accompanying attendants of the patients with cancer or those patients in the general hospital without cancer...
January 18, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28100195/assessment-of-the-length-of-sick-leave-in-patients-with-ischemic-heart-disease
#16
Nausica Català Tella, Catalina Serna Arnaiz, Jordi Real Gatius, Oriol Yuguero Torres, Leonardo Galván Santiago
BACKGROUND: The prevalence of ischemic heart disease is high. Few recent studies have investigated the periods of sick leave of these patients. Our aim is to determine the length of sick leave after an acute coronary syndrome, its costs, associated factors and to assess the use of antidepressants and/or anxiolytics. METHODS: An observational study of a retrospective cohort of patients on sick leave due to ischemic heart disease in a health region between 2008-2011, with follow-up until the first return to work, death, or end of the study (31/12/2012)...
January 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28100170/interaction-between-acyl-ghrelin-and-bmi-predicts-clinical-outcomes-in-hemodialysis-patients
#17
Ilia Beberashvili, Inna Sinuani, Ada Azar, Gregory Shapiro, Leonid Feldman, Keren Doenyas-Barak, Kobi Stav, Shai Efrati
BACKGROUND: Ghrelin, a gastric orexigenic peptide, and body mass index (BMI) are known as inversely associated to each other and are both linked to cardiovascular (CV) risk and mortality in maintenance hemodialysis (MHD) patients. However, it is unclear whether the interaction between ghrelin and BMI is associated with a risk of all-cause and CV death in this population. METHODS: A prospective observational study was performed on 261 MHD outpatients (39% women, mean age 68...
January 18, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28099971/warfarin-associated-nonuremic-calciphylaxis
#18
Wesley Yung-Hsu Yu, Tina Bhutani, Rachel Kornik, Laura B Pincus, Theodora Mauro, Michael D Rosenblum, Lindy P Fox
Importance: Classic calciphylaxis associated with renal failure is a life-threatening disease. Warfarin-associated calciphylaxis without renal injury has been described, but whether it is a subset of classic calciphylaxis or a different entity remains unknown. We describe 1 case of warfarin-associated calciphylaxis, present data from 2 others from our institution, and review all cases of warfarin-associated calciphylaxis available in the literature. Our review indicates that warfarin-associated calciphylaxis is clinically and pathophysiologically distinct from classic calciphylaxis...
January 11, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28099741/abortion-choices-among-women-in-cambodia-after-introduction-of-a-socially-marketed-medicated-abortion-product
#19
Khim Sotheary, Dianna Long, Gary Mundy, Yasmin Madan, Paul D Blumenthal
OBJECTIVE: To assess whether a social marketing initiative focusing on medicated abortion via a mifepristone/misoprostol "combipack" has contributed to reducing unsafe abortion in Cambodia. METHODS: In a questionnaire-based cross-sectional study, annual household surveys were conducted across 13 Cambodian provinces in 2010, 2011, and 2012. One married woman of reproductive age who was not pregnant and did not wish to be within the next 2 years in each randomly selected household was approached for inclusion...
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099592/epidemiological-analysis-of-occupational-dermatitis-notified-in-brazil-in-the-period-2007-to-2012
#20
Gabriela Yumi Plombom, Mariana Santos de Oliveira, Fernanda Lika Tabushi, Amanda Joekel Kassem, Kátia Sheylla Malta Purim, Renato Mitsunori Nisihara
BACKGROUND: Occupational dermatitis affects the quality of life and productivity of workers. Studies on the subject are scarce in Brazil. It is estimated that the disease is underreported and that many affected patients do not seek health care. OBJECTIVES: To conduct an epidemiological analysis of occupational dermatitis notified via SINAN in Brazil from January 2007 to December 2012; evaluate the profile of patients assisted; and check the main etiological agents involved...
November 2016: Anais Brasileiros de Dermatologia
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