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https://www.readbyqxmd.com/read/28545257/the-reactive-sulfur-species-concept-15-years-on
#1
REVIEW
Gregory I Giles, Muhammad Jawad Nasim, Wesam Ali, Claus Jacob
Fifteen years ago, in 2001, the concept of "Reactive Sulfur Species" or RSS was advocated as a working hypothesis. Since then various organic as well as inorganic RSS have attracted considerable interest and stimulated many new and often unexpected avenues in research and product development. During this time, it has become apparent that molecules with sulfur-containing functional groups are not just the passive "victims" of oxidative stress or simple conveyors of signals in cells, but can also be stressors in their own right, with pivotal roles in cellular function and homeostasis...
May 23, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28545202/memantine-inhibits-degradation-of-the-articular-cartilage-extracellular-matrix-induced-by-advanced-glycation-end-products-ages
#2
Jijun Zhao, Yinghao Yu, Zhaofeng Wu, Ling Wang, Wei Li
The accumulation of inflammation and cartilage damage induced by advanced glycation end products (AGEs) are important hallmarks of osteoarthritis (OA). Memantine is a clinically licensed drug used for the treatment of moderate and severe Alzheimer's disease. To date, little information has been reported regarding the effects of memantine on cartilage destruction. In this study, we investigated the protective effects of memantine on AGE-induced degradation of collagen II and aggrecans in human SW1353 chondrocytes...
May 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28545129/direct-and-indirect-costs-of-diabetes-mellitus-in-mali-a-case-control-study
#3
Clara Bermudez-Tamayo, Stéphane Besançon, Mira Johri, Sidibe Assa, Jonathan Betz Brown, Kaushik Ramaiya
BACKGROUND: Diabetes mellitus (DM) is one of the most burdensome chronic diseases and is associated with shorter lifetime, diminished quality of life and economic burdens on the patient and society as a result of healthcare, medication, and reduced labor market participation. We aimed to estimate the direct (medical and non-medical) and indirect costs of DM and compare them with those of people without DM (ND), as well as the cost predictors. METHODS AND FINDINGS: Observational retrospective case-control study performed in Mali...
2017: PloS One
https://www.readbyqxmd.com/read/28544836/aortic-valve-replacement-with-the-labcor-tlpb-supra%C3%A2-porcine-bioprosthesis-intermediate-clinical-and-echocardiographic-outcomes
#4
Markus Schlömicher, Zulfugar Taghiyev, Yazan Al-Jabery, Peter Lukas Haldenwang, Leif Markthaler, Vadim Moustafine, Axel Maria Laczkovics, Justus Thomas Strauch, Matthias Bechtel
BACKGROUND: The Labcor TBLP Supra™ prosthesis is a second-generation tissue valve that has evolved from the Labcor TBLP™ prosthesis, first introduced in 1984. The Supra prosthesis is a triple-composite porcine valve, with no specific anticalcification treatment being used in its production other than standard tissue fixation with 0.4% glutaraldehyde. To date, more than 100,000 Supra valves have been implanted, mainly in South America. Despite this remarkably high number of implants, only marginal data exist concerning durability and safety issues...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28544337/growth-curves-of-normal-serum-total-ige-levels-throughout-childhood-a-quantile-analysis-in-a-birth-cohort
#5
Chiara Sacco, Serena Perna, Donatella Vicari, Marco Alfò, Carl-Peter Bauer, Ute Hoffman, Johannes Forster, Fred Zepp, Antje Schuster, Ulrich Wahn, Thomas Keil, Susanne Lau, Paolo Maria Matricardi
BACKGROUND: Previous studies of serum total IgE (t-IgE) were not able to discriminate well enough atopic from non-atopic subjects, i.e. with or without serum-specific IgE antibodies to allergens. OBJECTIVES: To model growth curves of the total IgE levels in children without atopic sensitization (hereafter defined as "normal" t-IgE levels) and to test their usefulness in predicting atopic sensitization. METHODS: The German Multicentre Allergy Study (MAS), a birth cohort with 1314 recruited newborns, began in 1990 and examined the participants until age 20y...
May 25, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28544140/investigation-of-bronchiectasis-in-severe-uncontrolled-asthma
#6
Katerina Dimakou, Anna Gousiou, Michail Toumbis, Maria Kaponi, Serafeim Chrysikos, Loukas Thanos, Christina Triantafillidou
INTRODUCTION: The presence of bronchiectasis in patients with asthma varies in different reports, while a clear etiological relation has not been precisely established. OBJECTIVES: To investigate the presence of bronchiectasis in patients with severe uncontrolled asthma and examine whether they contribute to the severity of asthma. METHODS: Patients with severe asthma were prospectively recruited. HRCT of the chest was performed to identify and grade bronchiectasis using the "Smith" radiology scale...
May 24, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28544079/cough-is-less-common-and-less-severe-in-systemic-sclerosis-associated-interstitial-lung-disease-compared-to-other-fibrotic-interstitial-lung-diseases
#7
Jasmine Z Cheng, Pearce G Wilcox, Ian Glaspole, Tamera J Corte, Darra Murphy, Cameron J Hague, Christopher J Ryerson
BACKGROUND AND OBJECTIVE: The objectives of this study were to determine the prevalence and characteristics of cough in idiopathic pulmonary fibrosis (IPF), chronic hypersensitivity pneumonitis (HP) and systemic sclerosis-associated interstitial lung disease (SSc-ILD). METHODS: Cough severity was measured in consecutive patients with IPF (n = 77), HP (n = 32) and SSc-ILD (n = 67) using a 10-cm visual analogue scale (VAS). Dyspnoea and quality of life were measured using established questionnaires...
May 23, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28544067/vitamin-d3-alters-the-expression-of-toll-like-receptors-in-peripheral-blood-mononuclear-cells-of-patients-with-systemic-lupus-erythematosus
#8
Esmaeil Yazdanpanah, Mahmoud Mahmoudi, Maryam Sahebari, Zahra Rezaieyazdi, Seyed-Alireza Esmaeili, Nafiseh Tabasi, Soheila Jaberi, Amirhossein Sahebkar, Maryam Rastin
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by production of inflammatory cytokines and autoreactive antibodies due to the loss of immune tolerance. Recognition of self-nucleic acids by intracellular Toll-like receptors (TLRs) can overactivate immune responses and this abnormal activation of TLRs contributes to the pathogenesis of the disease. In recent years, anti-inflammatory and immunomodulatory effects of 1, 25-dihydroxyvitamin D3 (VitD3) on the immune system has received particular attention...
May 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28543688/glycated-human-albumin-alters-mitochondrial-respiration-in-preadipocyte-3t3-l1-cells
#9
Pascal Baret, Fanny Le Sage, Cynthia Planesse, Olivier Meilhac, Anne Devin, Emmanuel Bourdon, Philippe Rondeau
Diabetes and obesity are strongly associated with increased levels of circulating advanced glycation end products (AGEs) and reactive oxygen species (ROS). These two molecular phenomena affect the physiology of adipose tissue, a biological driver of the metabolic syndrome, leading to an inflammatory profile and insulin resistance, which could contribute to obesity/diabetes-associated complications, such as cardiovascular diseases. Herein, we investigated the impact of AGEs on mitochondrial bioenergetics in murine preadipocyte cells (3T3-L1) and cellular redox homeostasis...
May 22, 2017: BioFactors
https://www.readbyqxmd.com/read/28542837/phenotype-and-natural-history-of-variant-late-infantile-ceroid-lipofuscinosis-5
#10
Alessandro Simonati, Ruth E Williams, Nardo Nardocci, Minna Laine, Roberta Battini, Angela Schulz, Barbara Garavaglia, Francesca Moro, Francesco Pezzini, Filippo M Santorelli
AIM: To characterize the phenotypic profile of a cohort of children affected with CLN5, a rare form of neuronal ceroid-lipofuscinosis (NCL), and to trace the features of the natural history of the disease. METHOD: Records of 15 children (nine males, six females) were obtained from the data sets of the DEM-CHILD International NCL Registry. Disease progression was measured by rating six functional domains at different time points along the disease course. All patients underwent mutation analysis of the CLN5 gene and ultrastructural investigations of peripheral tissues...
May 25, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28542559/fluvastatin-inhibits-age-induced-cell-proliferation-and-migration-via-an-erk5-dependent-nrf2-pathway-in-vascular-smooth-muscle-cells
#11
Ae-Rang Hwang, Jung-Hwa Han, Jae Hyang Lim, Young Jin Kang, Chang-Hoon Woo
Advanced glycation endproduct (AGE)-induced vascular smooth muscle cell (VSMC) proliferation and reactive oxygen species (ROS) production are emerging as important mechanisms of diabetic vasculopathy, but little is known about the molecular mechanism responsible for the antioxidative effects of statins on AGEs. It has been reported that statins exert pleiotropic effects on the cardiovascular system due to decreases in AGE-induced cell proliferation, migration, and vascular inflammation. Thus, in the present study, the authors investigated the molecular mechanism by which statins decrease AGE-induced cell proliferation and VSMC migration...
2017: PloS One
https://www.readbyqxmd.com/read/28542534/the-carriage-of-interleukin-1b-31-c-allele-plus-staphylococcus-aureus-and-haemophilus-influenzae-increases-the-risk-of-recurrent-tonsillitis-in-a-mexican-population
#12
Baltazar González-Andrade, Ramiro Santos-Lartigue, Samantha Flores-Treviño, Natalie Sonia Ramirez-Ochoa, Paola Bocanegra-Ibarias, Francisco J Huerta-Torres, Soraya Mendoza-Olazarán, Licet Villarreal-Treviño, Adrián Camacho-Ortiz, Hipólito Villarreal-Vázquez, Elvira Garza-González
The aim of the present study was to estimate the relative contribution of immunogenetic and microbiological factors in the development of recurrent tonsillitis in a Mexican population. Patients (n = 138) with recurrent tonsillitis and an indication of tonsillectomy (mean age: 6.05 years ± 3.00; median age: 5 years, female: 58; age range: 1-15 years) and 195 non-related controls older than 18 years and a medical history free of recurrent tonsillitis were included. To evaluate the microbial contribution, tonsil swab samples from both groups and extracted tonsil samples from cases were cultured...
2017: PloS One
https://www.readbyqxmd.com/read/28542339/bioenergetic-profile-of-human-coronary-artery-smooth-muscle-cells-and-effect-of-metabolic-intervention
#13
Mingming Yang, Amy E Chadwick, Caroline Dart, Tomoko Kamishima, John M Quayle
Bioenergetics of artery smooth muscle cells is critical in cardiovascular health and disease. An acute rise in metabolic demand causes vasodilation in systemic circulation while a chronic shift in bioenergetic profile may lead to vascular diseases. A decrease in intracellular ATP level may trigger physiological responses while dedifferentiation of contractile smooth muscle cells to a proliferative and migratory phenotype is often observed during pathological processes. Although it is now possible to dissect multiple building blocks of bioenergetic components quantitatively, detailed cellular bioenergetics of artery smooth muscle cells is still largely unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28542247/genetic-polymorphism-of-merozoite-surface-protein-2-msp-2-in-plasmodium-falciparum-isolates-from-pawe-district-north-west-ethiopia
#14
Hussein Mohammed, Moges Kassa, Ashenafi Assefa, Mekonnen Tadesse, Amha Kebede
BACKGROUND: In malaria endemic regions, Plasmodium falciparum infection is characterized by extensive genetic diversity. Describing this diversity provides important information about the local malaria situation. This study was conducted to evaluate the extent of genetic diversity of P. falciparum in Pawe district, North West Ethiopia, using the highly polymorphic merozoite surface protein 2 gene. METHODS: Atotal of 92 isolates from patients with uncomplicated P...
2017: PloS One
https://www.readbyqxmd.com/read/28542144/dicer-and-micrornas-protect-adult-dopamine-neurons
#15
Piotr Chmielarz, Julia Konovalova, Syeda Sadia Najam, Heike Alter, Timo Petteri Piepponen, Holger Erfle, Kai C Sonntag, Günther Schütz, Ilya A Vinnikov, Andrii Domanskyi
MicroRNAs (miRs) are important post-transcriptional regulators of gene expression implicated in neuronal development, differentiation, aging and neurodegenerative diseases, including Parkinson's disease (PD). Several miRs have been linked to PD-associated genes, apoptosis and stress response pathways, suggesting that deregulation of miRs may contribute to the development of the neurodegenerative phenotype. Here, we investigate the cell-autonomous role of miR processing RNAse Dicer in the functional maintenance of adult dopamine (DA) neurons...
May 25, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28542133/protein-disulfide-isomerase-mediated-apoptosis-and-proliferation-of-vascular-smooth-muscle-cells-induced-by-mechanical-stress-and-advanced-glycosylation-end-products-result-in-diabetic-mouse-vein-graft-atherosclerosis
#16
Suning Ping, Shuying Liu, Yuhuan Zhou, Ziqing Li, Yuhuang Li, Kefeng Liu, Adham Sa Bardeesi, Linli Wang, Jingbo Chen, Lie Deng, Jingjing Wang, Hong Wang, Dadi Chen, Zhengyu Zhang, Puyi Sheng, Chaohong Li
Protein disulfide isomerase (PDI) involves cell survival and death. Whether PDI mediates mechanical stretch stress (SS) and/or advanced glycosylation end products (AGEs) -triggered simultaneous increases in proliferation and apoptosis of vascular smooth muscle cells (VSMCs) is unknown. Here, we hypothesized that different expression levels of PDI trigger completely opposite cell fates among the different VSMC subtypes. Mouse veins were grafted into carotid arteries of non-diabetic and diabetic mice for 8 weeks; the grafted veins underwent simultaneous increases in proliferation and apoptosis, which triggered vein graft arterializations in non-diabetic or atherosclerosis in diabetic mice...
May 25, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28542123/malaria-surveillance-united-states-2014
#17
Kimberly E Mace, Paul M Arguin
PROBLEM/CONDITION: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the bite of an infective female Anopheles mosquito. The majority of malaria infections in the United States occur among persons who have traveled to regions with ongoing malaria transmission. However, malaria is occasionally acquired by persons who have not traveled out of the country through exposure to infected blood products, congenital transmission, laboratory exposure, or local mosquitoborne transmission...
May 26, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28542119/current-tobacco-smoking-and-desire-to-quit-smoking-among-students-aged-13-15-years-global-youth-tobacco-survey-61-countries-2012-2015
#18
René A Arrazola, Indu B Ahluwalia, Eugene Pun, Isabel Garcia de Quevedo, Stephen Babb, Brian S Armour
Tobacco use is the world's leading cause of preventable morbidity and mortality, resulting in nearly 6 million deaths each year (1). Smoked tobacco products, such as cigarettes and cigars, are the most common form of tobacco consumed worldwide (2), and most tobacco smokers begin smoking during adolescence (3). The health benefits of quitting are greater for persons who stop smoking at earlier ages; however, quitting smoking at any age has health benefits (4). CDC used the Global Youth Tobacco Survey (GYTS) data from 61 countries across the six World Health Organization (WHO) regions from 2012 to 2015 to examine the prevalence of current tobacco smoking and desire to quit smoking among students aged 13-15 years...
May 26, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28541868/perceptions-of-harm-to-children-exposed-to-secondhand-aerosol-from-electronic-vapor-products-styles-survey-2015
#19
Kimberly H Nguyen, Van T Tong, Kristy Marynak, Brian A King
INTRODUCTION: The US Surgeon General has concluded that e-cigarette aerosol is not harmless and can contain harmful and potentially harmful chemicals, including nicotine. We assessed factors associated with adults' perceptions of harm related to children's exposure to secondhand aerosol from electronic vapor products (EVPs). METHODS: Data came from the 2015 Styles, an Internet panel survey of US adults aged 18 years or older (n = 4,127). Respondents were asked whether they believe aerosol from other people's EVPs causes children harm...
May 25, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28541629/adult-granulosa-cell-tumors-of-the-ovary-a-retrospective-study-of-30-cases-with-respect-to-the-expression-of-steroid-synthesis-enzymes
#20
Sachiko Kitamura, Kaoru Abiko, Noriomi Matsumura, Hidekatsu Nakai, Yumiko Akimoto, Hirotoshi Tanimoto, Ikuo Konishi
OBJECTIVE: Some, but not all, granulosa cell tumors are characterized by estrogen production. This study was designed to determine whether there are clinical or pathological variations in granulosa cell tumors in relation to the expression of sex steroid synthesis enzymes. METHODS: Clinical symptoms, serum hormonal values, and histology of 30 granulosa cell tumor patients who underwent surgery between 2002 and 2014 were retrospectively reviewed. RESULTS: Most patients presented with abnormal genital bleeding including abnormal menstrual cycles...
July 2017: Journal of Gynecologic Oncology
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