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https://www.readbyqxmd.com/read/29055268/early-age-of-e-cigarette-use-onset-mediates-the-association-between-impulsivity-and-e-cigarette-use-frequency-in-youth
#1
Krysten W Bold, Meghan E Morean, Grace Kong, Patricia Simon, Deepa R Camenga, Dana A Cavallo, Suchitra Krishnan-Sarin
BACKGROUND: Identifying risk factors for youth e-cigarette use is critical, given high rates of e-cigarette use and unknown health effects of long-term use. The current study examined whether an early age of onset of e-cigarette use mediates the association between impulsivity and e-cigarette frequency. METHODS: Cross-sectional survey data of e-cigarette users (n=927) were collected from 8 high schools in southeastern Connecticut. The sample was 44.7% female (mean age 16...
October 13, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29055022/the-addition-of-a-developmental-factor-unc-62-to-already-long-lived-worms-increases-lifespan-and-healthspan
#2
Dror Sagi
Aging is a complex trait that is affected by multiple genetic pathways. A relatively unexplored approach is to manipulate multiple independent aging pathways simultaneously in order to observe their cumulative effect on lifespan. Here, we report the phenotypic characterization of a strain with changes in five aging pathways: 1) mitochondrial ROS production, 2) innate immunity, 3) stress response, 4) metabolic control and 5) developmental regulation in old age. The quintuply-modified strain has a lifespan that is 160% longer than the transgenic control strain...
October 20, 2017: Biology Open
https://www.readbyqxmd.com/read/29054655/association-of-serum-levels-of-perfluoroalkyl-substances-pfass-with-the-metabolic-syndrome-mets-in-chinese-male-adults-a-cross-sectional-study
#3
Qiaoyun Yang, Xiaoli Guo, Pengling Sun, Yujiao Chen, Wei Zhang, Ai Gao
As extensively used chemicals in a variety of consumer products, perfluoroalkyl substances (PFASs) are ubiquitous and could bring significant risk to human health. However, the effect of PFASs on metabolic syndrome (MetS) is not fully understood. In 2015, a preliminary cross-sectional study was undertaken. A total of 148 male subjects including 81 affected by MetS and 67 non-MetS participants as the reference were recruited from Physical Examination Center affiliated to Capital Medical University, China. Serum levels of perfluorohexane sulfonic acid (PFHxS), perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) were significantly higher in the subjects with MetS...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054646/heavy-metal-accumulation-and-health-risk-assessment-in-soil-wheat-system-under-different-nitrogen-levels
#4
Yang Zhang, Changbin Yin, Suzhen Cao, Leilei Cheng, Guosheng Wu, Jianbiao Guo
Heavy metal(loid)s (HMs) in organic fertilizer have become a primary source of HMs pollution of farmlands, which could cause deleterious health effects in people exposed through soil-plant systems via multi-pathways. This study investigated China's main grain production area (Henan Province) to evaluate the accumulation and transport characteristics of HMs (Cr, Mn, Ni, Cu, Zn, As, Cd and Pb) in a soil-wheat system and conduct a health risk assessment for wheat (Triticum aestivum) grain under different nitrogenous fertilizer treatments...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054627/influence-of-diet-in-urinary-levels-of-metals-in-a-biomonitoring-study-of-a-child-population-of-the-valencian-region-spain
#5
Rosa Pérez, Eva Doménech, Andrea Conchado, Alfredo Sanchez, Clara Coscollà, Vicent Yusà
Pollution by trace elements and its possible effect on organisms has become a worldwide concern due to the increasing presence of trace elements in the environment and especially in the food chain. Exposure to chemicals has traditionally been measured using environmental samples, however, human biomonitoring brings a different perspective, in which all sources and exposure pathways are integrated. The objective of this paper is to discern the possible relationship between children's diet and the metals found in children urine...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054589/baseline-asthma-burden-comorbidities-and-biomarkers-in-omalizumab-treated-patients-in-prospero
#6
Bradley E Chipps, Robert S Zeiger, Allan T Luskin, William W Busse, Benjamin L Trzaskoma, Evgeniya N Antonova, Hooman Pazwash, Susan L Limb, Paul G Solari, Noelle M Griffin, Thomas B Casale
BACKGROUND: Patients included in clinical trials do not necessarily reflect the real-world population. OBJECTIVE: To understand the characteristics, including disease and comorbidity burden, of patients with asthma receiving omalizumab in a real-world setting. METHODS: The Prospective Observational Study to Evaluate Predictors of Clinical Effectiveness in Response to Omalizumab (PROSPERO) was a US-based, multicenter, single-arm, and prospective study...
October 17, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29054583/dietary-resveratrol-increases-mid-life-fecundity-of-female-nothobranchius-guentheri
#7
Youngjoo Lee, Andrew C Drake, Nicholas O Thomas, Lindsey G Ferguson, Patrick E Chappell, Kate Petersen Shay
The decline of female reproductive function is an early phenotype of aging in humans, occurring only midway through the lifespan. Yet the number of women delaying pregnancy continues to rise in industrialized societies due to personal or socioeconomic circumstances, often resulting in subfertility or difficulty conceiving. There are few defined mechanisms associated with this etiology, and equally few effective therapies. To combat this problem, we used a novel emerging model, Nothobranchius guentheri, that recapitulates the age-associated spectrum of changes that adversely affect human fertility...
October 17, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29054326/development-and-validation-of-the-comprehensive-praxis-assessment-for-children-aged-6-8
#8
Shao-Hsia Chang, Nan-Ying Yu
This study examined the psychometric properties of motor praxis using a large school-based sample of children (n=239). We developed and evaluated the construct validity of a motor praxis assessment using confirmatory factor analysis (CFA). A model with four latent variables was evaluated for goodness of fit. CFA established that the scale was multifactorial and supported the four-factor model (motor imagery, verbal gesture production, imitative gesture production and knowledge of object-use). The internal consistency, inter-rater reliability and concurrent validity of the praxis assessment mostly demonstrated good to excellent results for the full scale and the subscales...
October 17, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29054272/insights-on-the-hla-binding-peptidome-in-cancer
#9
Douglas F Lake
The intracellular compartments for proteolytic antigen processing in tumor cells produce peptides that are presented by MHC molecules to T cells. But first, the ubiquitin ligase system tags defective, misfolded, aged, and unstable proteins for degradation through the proteasome. Ubiqitinated proteins are unfolded and fed into the barrel-shaped core of the proteasome where a collection of multiple different proteases cleave proteins into oligopeptides. After exiting the proteasome, these oligopeptides are either completely degraded into amino acids or trimmed at the N- and C-termini so that they bind to transporter associated with antigen processing (TAP)...
2017: Enzymes
https://www.readbyqxmd.com/read/29054073/discourse-production-of-mandarin-speaking-children-with-high-functioning-autism-the-effect-of-mental-and-action-verbs-semantic-pragmatic-features
#10
Yiqi Song, Zhongheng Jia, Shunhua Liu, Dandan Liang
The present study investigated the syntactic and pragmatic performance of children with high-functioning autism (HFA) during a discourse production task with mental verbs. Children with HFA and typically developing (TD) children were matched by chronological age, verbal IQ (VIQ) and full-scale IQ (FIQ). We found that children with HFA tended to select a nominal object given a mental verb with either a nominal or clausal object. They committed few syntactic errors but generated syntactic stereotypes with mental verbs...
October 16, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/29054044/metacognitive-deficits-in-categorization-tasks-in-a-population-with-impaired-inner-speech
#11
Peter Langland-Hassan, Christopher Gauker, Michael J Richardson, Aimee Dietz, Frank R Faries
This study examines the relation of language use to a person's ability to perform categorization tasks and to assess their own abilities in those categorization tasks. A silent rhyming task was used to confirm that a group of people with post-stroke aphasia (PWA) had corresponding covert language production (or "inner speech") impairments. The performance of the PWA was then compared to that of age- and education-matched healthy controls on three kinds of categorization tasks and on metacognitive self-assessments of their performance on those tasks...
October 17, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/29053994/dietary-resveratrol-confers-apoptotic-resistance-to-oxidative-stress-in-myoblasts
#12
Satoshi Haramizu, Shinichi Asano, David C Butler, David A Stanton, Ameena Hajira, Junaith S Mohamed, Stephen E Alway
High levels of reactive oxygen species (ROS) contribute to muscle cell death in aging and disuse. We have previously found that resveratrol can reduce oxidative stress in response to aging and hindlimb unloading in rodents in vivo, but it was not known if resveratrol would protect muscle stem cells during repair or regeneration when oxidative stress is high. To test the protective role of resveratrol on muscle stem cells directly, we treated the C2C12 mouse myoblast cell line with moderate (100 μM) or very high (1 mM) levels of H2O2 in the presence or absence of resveratrol...
August 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29053889/optimization-of-mass-spectrometry-acquisition-parameters-for-determination-of-polycarbonate-additives-degradation-products-and-colorants-migrating-from-food-contact-materials-to-chocolate
#13
Chiara Bignardi, Antonella Cavazza, Carmen Laganà, Paola Salvadeo, Claudio Corradini
The interest towards the so-called "substances of emerging concerns", in particular referred to objects intended to come into contact with food is recently growing. Such substances can be found in traces in simulants and in food products put in contact with plastic materials. In this context, it is important to set up analytical systems characterized by high sensitivity, and to improve detection parameters to enhance signals. This work was aimed at optimizing a method based on UHPLC coupled to High Resolution Mass Spectrometry to quantify the most common plastic additives, and able to detect the presence of polymers degradation products and coloring agents migrating from plastic re-usable containers...
October 20, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29053859/unexpected-results-when-assessing-underlying-aggressiveness-in-japanese-quail-using-photocastrated-stimulus-birds
#14
J M Caliva, J M Kembro, S Pellegrini, D A Guzman, R H Marin
Aggressive behaviors can affect both animal welfare and productivity. Because the expression of aggressive behaviors is dependent on the quality of the opponent, they reflect relative rather than absolute levels of underlying aggressiveness. This study was aimed to characterize the aggressive responsiveness of photostimulated (14:10 h light:dark photoperiod) adult Japanese quail when interacting with a photocastrated (6:18 h light:dark photoperiod) counterpart in a novel test environment and to assesses interindividual variations...
October 10, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053828/effect-of-synbiotic-supplementation-on-layer-production-and-cecal-salmonella-load-during-a-salmonella-challenge
#15
A Luoma, A Markazi, R Shanmugasundaram, G R Murugesan, M Mohnl, R Selvaraj
This study analyzed the inhibitory effects of a synbiotic product (PoultryStar® me) on production parameters, intestinal microflora profile, and immune parameters in laying hens with and without a Salmonella challenge. The synbiotic product contained 4 probiotic bacterial strains (Lactobacillus reuteri, Enterococcus faecium, Bifidobacterium animalis, and Pediococcus acidilactici) and a prebiotic fructooligosaccharide. Layers were supplemented with the synbiotic from d of hatch to 28 wk of age. At 16 wk of age, birds were either vaccinated with Salmonella enterica Enteritidis (SE) vaccine or left unvaccinated...
September 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053741/the-importance-of-propolis-in-alleviating-the-negative-physiological-effects-of-heat-stress-in-quail-chicks
#16
Gamal M K Mehaisen, Rania M Ibrahim, Adel A Desoky, Hosam M Safaa, Osama A El-Sayed, Ahmed O Abass
Heat stress is one of the most detrimental confrontations in tropical and subtropical regions of the world, causing considerable economic losses in poultry production. Propolis, a resinous product of worker honeybees, possesses several biological activities that could be used to alleviate the deleterious effects of high environmental temperature on poultry production. The current study was aimed at evaluating the effects of propolis supplementation to Japanese quail (Coturnix coturnix japonica) diets on the production performance, intestinal histomorphology, relative physiological and immunological parameters, and selected gene expression under heat stress conditions...
2017: PloS One
https://www.readbyqxmd.com/read/29053628/antioxidant-defence-oxidative-stress-and-oxidative-damage-in-saliva-plasma-and-erythrocytes-of-dementia-patients-can-salivary-age-be-a-marker-of-dementia
#17
Magdalena Choromańska, Anna Klimiuk, Paula Kostecka-Sochoń, Karolina Wilczyńska, Mikołaj Kwiatkowski, Natalia Okuniewska, Napoleon Waszkiewicz, Anna Zalewska, Mateusz Maciejczyk
Oxidative stress plays a crucial role in dementia pathogenesis; however, its impact on salivary secretion and salivary qualities is still unknown. This study included 80 patients with moderate dementia and 80 healthy age- and sex-matched individuals. Salivary flow, antioxidants (salivary peroxidase, catalase, superoxide dismutase, uric acid and total antioxidant capacity), and oxidative damage products (advanced oxidation protein products, advanced glycation end products (AGE), 8-isoprostanes, 8-hydroxy-2'-deoxyguanosine and total oxidant status) were estimated in non-stimulated and stimulated saliva, as well as in plasma and erythrocytes...
October 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29052954/enlarged-perivascular-spaces-are-associated-with-health-related-quality-of-life-in-patients-with-acute-ischemic-stroke
#18
Yan Liang, Min Deng, Yang-Kun Chen, Vincent Mok, De-Feng Wang, Gabor S Ungvari, Chiu-Wing Winnie Chu, Eivind Berge, Wai-Kwong Tang
AIMS: This study explored the association between enlarged perivascular spaces (EPVS) and the health-related quality of life (HRQoL) in patients with acute ischemic stroke. METHODS: This was an observational study of consecutively screened patients with acute ischemic stroke from March 2010 to March 2015. EPVS were rated in the basal ganglia and the centrum semiovale with a validated scale. The HRQoL was assessed 3 months after the stroke onset using the Stroke-Specific Quality of Life (SSQoL)...
October 20, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29052845/the-advanced-glycation-end-product-n-%C3%AF%C2%B5-carboxymethyllysine-and-its-precursor-glyoxal-increase-serotonin-release-from-caco-2-cells
#19
Ann-Katrin Holik, Barbara Lieder, Nicole Kretschy, Mark M Somoza, Jakob P Ley, Joachim Hans, Veronika Somoza
Advanced glycation end products (AGEs), comprising a highly diverse class of Maillard reaction compounds formed in vivo and during heating processes of foods, have been described in the progression of several degenerative conditions such as Alzheimer's disease and diabetes mellitus. N(ϵ) -Carboxymethyllysine (CML) represents a well-characterized AGE, which is frequently encountered in a Western diet and is known to mediate its cellular effects through binding to the receptor for AGEs (RAGE). Since very little is known about the impact of exogenous CML and its precursor, glyoxal, on intestinal cells, a genome-wide screening using a customized microarray was conducted in fully differentiated Caco-2 cells...
October 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29052388/-comparison-of-development-condition-of-different-liriope-spicata-seedlings
#20
Yue Wang, He Su, Yan-Ting Zhan, Yang Yang, Xue-Hui Dong
The study identified the main morphological index of the seedlings classification including seedling age,the root width and number of newborn buds and coarse roots, according to the local agricultural production techniques and assessment of Liriope spicata's growth and development condition. After carrying on K cluster analysis of the morphological, we separated the seedlings into two levels. The first level (Ⅰ): the new talent with the root width exceeding two point five millimeters, the new born buds exceeding three, and with the coarse root exceeding one...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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