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https://www.readbyqxmd.com/read/29748135/oncogenic-kras-suppresses-store-operated-ca-2-entry-and-i-crac-through-erk-pathway-dependent-remodelling-of-stim-expression-in-colorectal-cancer-cell-lines
#1
Cristina Pierro, Xuexin Zhang, Cynthia Kankeu, Mohamed Trebak, Martin D Bootman, H Llewelyn Roderick
The KRAS GTPase plays a fundamental role in transducing signals from plasma membrane growth factor receptors to downstream signalling pathways controlling cell proliferation, survival and migration. Activating KRAS mutations are found in 20% of all cancers and in up to 40% of colorectal cancers, where they contribute to dysregulation of cell processes underlying oncogenic transformation. Multiple KRAS-regulated cell functions are also influenced by changes in intracellular Ca2+ levels that are concurrently modified by receptor signalling pathways...
March 14, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29703078/advances-in-studies-of-aptamer-protein-targets-identification-using-chromatographic-approach
#2
Anna Drabik, Joanna Ner-Kluza, Przemyslaw Mielczarek, Laia Civit, Günter Mayer, Jerzy Silberring
Ever since the development of the process known as Systematic Evolution of Ligands by EXponential enrichment (SELEX) aptamers are widely used in variety of studies, including exploration of new diagnostic tools and discovery of new treatment methods. Aptamers abilities to bind to proteins with high affinity and specificity, often compared to antibodies, enable the search for potential cancer biomarkers and help to understand the mechanisms of cancerogenesis. The blind-spot of those investigations is usually the difficulty in selective extraction of targets attached to the aptamer...
April 27, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29692656/biomarkers-could-facilitate-prediction-of-worse-clinical-outcome-of-cancer-with-special-insight-to-cervical-cancer
#3
REVIEW
Bartosz Czerniak, Dorota Olszewska-Słonina
Cervical cancer incidence, globally, is second only to malignant breast cancer. The main causative factor is thought to be human papillomavirus (HPV) infection as a result of many sexual partners. Despite radiotherapy, chemotherapy and surgical treatment, the survival rate of patients with advanced disease is low. Metastasis is one of the stages of cancerogenesis in which tumour cells acquire the ability to migrate and create tumour secondary foci. Tumour biomarkers, proteins produced by neoplastic cells, quantified in body fluids or in tissues, play a key role in treatment monitoring and in determining the prognosis for further years of life...
2018: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29692246/an-evaluation-of-the-antioxidant-and-anticancer-properties-of-complex-compounds-of-copper-ii-platinum-ii-palladium-ii-and-ruthenium-iii-for-use-in-cancer-therapy
#4
Anna Katarzyna Szczepanska, Katarzyna Malinowska, Ireneusz Majsterek
The incidence of head and neck cancer increases every year, and represents a significant problem for Molecular Biology at the beginning of the twenty-first Century. Despite advances in treatment, most studies still strive to deepen the understanding of the mechanisms of cancerogenesis. In order to develop more effective methods of diagnosis and therapy, it is necessary to understand the molecular basis of the neoplastic transformation process. Such findings obtained by research into Molecular Biology, Molecular Epidemiology and Genetics have brought significant progress in understanding the complex, multi-step process which takes place during tumor formation...
April 23, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29542055/use-of-u-stela-for-accurate-measurement-of-extremely-short-telomeres
#5
Nedime Serakinci, Huseyin Cagsin, Merdiye Mavis
Telomeres are repetitive genetic materials that protect the chromosomes by capping the ends of chromosomes. Each time a cell divides, telomeres get shorter. Telomere length is mainly maintained by telomerase. This enzyme is present in the embryonic stem cells in high concentrations and declines with age. It is still unclear to what extend there is telomerase in adult stem cells, but considering these are the founder cells to the cells of the all tissues in a body, understanding the telomere dynamics and expression of telomerase in adult stem cells is very important...
March 15, 2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29541276/epidemiology-of-hepatitis-b-virus-hbv-and-hepatitis-c-virus-hcv-related-hepatocellular-carcinoma
#6
REVIEW
Arnolfo Petruzziello
Introduction: Hepatocellular carcinoma (HCC) is one of the most prevalent primary malignant tumors and accounts for about 90% of all primary liver cancers. Its distribution varies greatly according to geographic location and it is more common in middle and low- income countries than in developed ones especially in Eastern Asia and Sub Saharan Africa (70% of all new HCCs worldwide), with incidence rates of over 20 per 100,000 individuals. Explanation: The most important risk factors for HCC are Hepatitis B Virus (HBV) infection, Hepatitis C Virus (HCV) infection, excessive consumption of alcohol and exposition to aflatoxin B1...
2018: Open Virology Journal
https://www.readbyqxmd.com/read/29513947/the-estrogens-chromium-interaction-in-the-nitric-oxide-generation
#7
Ewa Sawicka, Agnieszka Piwowar, Tomasz Musiala, Anna Dlugosz
The interaction of estrogens with environmental toxins in free radicals generation: reactive oxygen species (ROS) or reactive nitrogen species (RNS) which participates in cancerogenesis is not yet recognized. Chromium(VI) is widely present in environment. One of its toxicity pathway is free radicals generation. Estrogens have the ability to scavenge free radicals, but may also act as prooxidants. Both chromium(VI) and estrogens are classified by International Agency for Research on Cancer (IARC) as carcinogens, so synergistic effect seems very dangerous...
May 2017: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/29477555/htra3-is-a-cellular-partner-of-cytoskeleton-proteins-and-tcp1%C3%AE-chaperonin
#8
Tomasz Wenta, Dorota Zurawa-Janicka, Michal Rychlowski, Miroslaw Jarzab, Przemyslaw Glaza, Andrea Lipinska, Krystyna Bienkowska-Szewczyk, Anna Herman-Antosiewicz, Joanna Skorko-Glonek, Barbara Lipinska
The human HtrA3 protease is involved in placentation, mitochondrial homeostasis, stimulation of apoptosis and proposed to be a tumor suppressor. Molecular mechanisms of the HtrA3 functions are poorly understood and knowledge concerning its cellular targets is very limited. There are two HtrA3 isoforms, the long (HtrA3L) and short (HtrA3S). Upon stress, their N-terminal domains are removed, resulting in the more active ΔN-HtrA3. By pull down and mass spectrometry techniques, we identified a panel of putative ΔN-HtrA3L/S substrates...
April 15, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29462646/cbx3-promotes-tumor-proliferation-by-regulating-g1-s-phase-via-p21-downregulation-and-associates-with-poor-prognosis-in-tongue-squamous-cell-carcinoma
#9
HuaYong Zhang, WeiChao Chen, XiaoYan Fu, Xuan Su, AnKui Yang
Chromobox protein homolog 3 (CBX3), a core component of the heterochromatin proteins 1, is recently proved to be involved in human cancerogenesis and associated with the prognosis of patient. However, the role of CBX3 in Tongue squamous cell carcinoma (TSCC) remains unclear. In the present study we found that CBX3 was upregulated in TSCC tissues when compared to adjacent non-tumor tissues, and multivariable analysis showed that high CBX3 expression was associated with clinical stage and cervical node metastasis, which was an independent prognostic indicator of TSCC...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29370181/inferring-hidden-causal-relations-between-pathway-members-using-reduced-google-matrix-of-directed-biological-networks
#10
José Lages, Dima L Shepelyansky, Andrei Zinovyev
Signaling pathways represent parts of the global biological molecular network which connects them into a seamless whole through complex direct and indirect (hidden) crosstalk whose structure can change during development or in pathological conditions. We suggest a novel methodology, called Googlomics, for the structural analysis of directed biological networks using spectral analysis of their Google matrices, using parallels with quantum scattering theory, developed for nuclear and mesoscopic physics and quantum chaos...
2018: PloS One
https://www.readbyqxmd.com/read/29339244/epigenetics-of-breast-cancer-biology-and-clinical-implication-in-the-era-of-precision-medicine
#11
REVIEW
Barbara Pasculli, Raffaela Barbano, Paola Parrella
In the last years, mortality from breast cancer has declined in western countries as a consequence of a more widespread screening resulting in earlier detection, as well as an improved molecular classification and advances in adjuvant treatment. Nevertheless, approximately one third of breast cancer patients will develop distant metastases and eventually die for the disease. There is now a compelling body of evidence suggesting that epigenetic modifications comprising DNA methylation and chromatin remodeling play a pivotal role since the early stages of breast cancerogenesis...
January 12, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29258187/usefulness-of-amino-acid-profiling-in-ovarian-cancer-screening-with-special-emphasis-on-their-role-in-cancerogenesis
#12
Szymon Plewa, Agnieszka Horała, Paweł Dereziński, Agnieszka Klupczynska, Ewa Nowak-Markwitz, Jan Matysiak, Zenon J Kokot
The aim of this study was to quantitate 42 serum-free amino acids, propose the biochemical explanation of their role in tumor development, and identify new ovarian cancer (OC) biomarkers for potential use in OC screening. The additional value of this work is the schematic presentation of the interrelationship between metabolites which were identified as significant for OC development and progression. The liquid chromatography-tandem mass spectrometry technique using highly-selective multiple reaction monitoring mode and labeled internal standards for each analyzed compound was applied...
December 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29238337/the-role-of-type-2-diabetes-for-the-development-of-pathogen-associated-cancers-in-the-face-of-the-hiv-aids-epidemic
#13
REVIEW
Melissa J Blumenthal, Sylvia Ujma, Arieh A Katz, Georgia Schäfer
The contribution of HIV to the development of pathogen-associated cancers has long been recognized, as has the contribution of type 2 diabetes for the development of several types of cancer. While HIV/AIDS-associated immunosuppression reduces immunosurveillance and indirectly contributes favorably to cancerogenesis, diabetes directly increases cancer development due to chronic low-grade inflammation, dysregulated glucose metabolism, hyperactivation of insulin-responsive pathways, and anti-apoptotic signaling...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29217202/cell-free-production-purification-and-characterization-of-human-mitochondrial-adp-atp-carriers
#14
Aleksandra Woznicka-Misaila, Céline Juillan-Binard, Delphine Baud, Eva Pebay-Peyroula, Stéphanie Ravaud
Mitochondrial Carriers (MCs) are responsible for fluent traffic of a variety of compounds that need to be shuttled via mitochondrial inner membranes to maintain cell metabolism. The ADP/ATP Carriers (AACs) are responsible for the import of ADP inside the mitochondria and the export of newly synthesized ATP. In human, four different AACs isoforms are described which are expressed in tissue-specific manner. They are involved in different genetic diseases and play a role in cancerogenesis. Up to now only the structures of the bovine (isoform 1) and yeast (isoforms 2 and 3) AAC have been determined in one particular conformation, obtained in complex with the CATR inhibitor...
April 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29173487/serum-and-whole-blood-zn-cu-and-mn-profiles-and-their-relation-to-redox-status-in-lung-cancer-patients
#15
Katarzyna Zabłocka-Słowińska, Sylwia Płaczkowska, Anna Prescha, Konrad Pawełczyk, Irena Porębska, Monika Kosacka, Lilla Pawlik-Sobecka, Halina Grajeta
Disturbed redox status may be critical to lung cancerogenesis, however little research has been conducted on general changes in total redox status in lung cancer. Levels and activities of antioxidants, especially enzymatic ones, are related to trace element concentration. Trace element status is often disturbed in cancers, however no studies concerning the association between redox and trace element status have been performed for lung cancer. We hypothesized that disturbed redox status in lung cancer patients is partially determined by trace elements while their distribution amongst blood compartments may differ compared to healthy subjects...
January 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29148034/role-of-p62-sqstm1-beyond-autophagy-a-lesson-learned-from-drug-induced-toxicity-in-vitro
#16
Fernando Alegre, Ángela B Moragrega, Miriam Polo, Alberto Marti-Rodrigo, Juan V Esplugues, Ana Blas-Garcia, Nadezda Apostolova
BACKGROUND AND PURPOSE: SQSTM1/p62 is a multifunctional, stress-induced, scaffold protein involved in multiple cellular processes including autophagic clearance, regulation of inflammatory responses and redox homeostasis. Its altered function has been associated with different human pathologies, such as neurodegenerative, metabolic and bone diseases (down-regulation), and cancerogenesis (up-regulation). However, its role in the off-target effects of clinically used drugs is still not understood...
February 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29137935/prostatic-adenocarcinoma-in-the-setting-of-persistent-m%C3%A3-llerian-duct-syndrome-a-case-report
#17
Zulfia McCroskey, Tracie M Koen, David J Lim, Mukul K Divatia, Steven S Shen, Alberto G Ayala, Jae Y Ro
Persistent Müllerian Duct Syndrome (PMDS) is a form of disordered sex development in which rudimentary Müllerian structures are identified in phenotypically and genotypically normal males. It is caused by defects in the anti-Müllerian hormone (AMH) system. Since patients with PMDS present with undescended testes, testosterone production by Leydig cells later in life is often decreased. The role of androgens in prostate cancerogenesis is well known. Cryptorchid testes and diminished testosterone levels in post pubertal life in patients with PMDS play a protective role against prostate cancer, and hence, prostate cancer is a rare event in patients with PMDS...
November 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/29130357/biological-effects-of-metal-degradation-in-hip-arthroplasties
#18
Donatella Granchi, Lucia Maria Savarino, Gabriela Ciapetti, Nicola Baldini
Metals and metal alloys are the most used materials in orthopedic implants. The focus is on total hip arthroplasty (THA) that, though well tolerated, may be associated with local and remote adverse effects in the medium-long term. This review aims to summarize data on the biological consequences of the metal implant degradation that have been attributed predominantly to metal-on-metal (MoM) THA. Local responses to metals consist of a broad clinical spectrum ranging from small asymptomatic tissue lesions to severe destruction of bone and soft tissues, which are designated as metallosis, adverse reactions to metal debris (ARMD), aseptic lymphocytic vasculitis associated lesion (ALVAL), and pseudotumors...
February 2018: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29123417/the-expression-profile-and-clinical-significance-of-circrna0003906-in-colorectal-cancer
#19
Fan Zhuo, Huashan Lin, Zhixin Chen, Zhijun Huang, Jiaping Hu
Colorectal cancer (CRC) remains a major health problem worldwide and the detailed mechanisms of CRC still need further understanding. Circular RNAs (circRNAs), a special class of endogenous RNAs, have emerged recently as a new potential player in governing fundamental biological process and cancer progression. In this study, we chose circRNA0003906 as a targeted circRNA to evaluate its expression pattern and clinical value in CRC patients. circRNA0003906 expression level in 6 CRC cell lines and 122 paired CRC tissues was measured by quantitative real-time polymerase chain reaction...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29080344/bile-acids-and-cancer-direct-and-environmental-dependent-effects
#20
Agostino Di Ciaula, David Q-H Wang, Emilio Molina-Molina, Raquel Lunardi Baccetto, Giuseppe Calamita, Vincenzo O Palmieri, Piero Portincasa
Bile acids (BAs) regulate the absorption of fat-soluble vitamins, cholesterol and lipids but have also a key role as singalling molecules and in the modulation of epithelial cell proliferation, gene expression and metabolism. These homeostatic pathways, when disrupted, are able to promote local inflammation, systemic metabolic disorders and, ultimately, cancer. The effect of hydrophobic BAs, in particular, can be linked with cancer in several digestive (mainly oesophagus, stomach, liver, pancreas, biliary tract, colon) and extra-digestive organs (i...
November 2017: Annals of Hepatology
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