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https://www.readbyqxmd.com/read/28639131/mirna-signature-of-hepatocellular-carcinoma-vascularization-how-the-controls-can-influence-the-signature
#1
Silvia Fittipaldi, Francesco Vasuri, Sonia Bonora, Alessio Degiovanni, Giacomo Santandrea, Alessandro Cucchetti, Laura Gramantieri, Luigi Bolondi, Antonia D'Errico
BACKGROUND: miRNA deregulation and vascular modifications constitute promising predictors in the study of hepatocellular carcinoma (HCC). In the literature, the relative miRNA abundance in HCC is usually determined using as control non-matched tumoral tissue, healthy liver, or cirrhotic liver. However, a common standard RNA control for the normalization toward the tissue gene expression was not settled yet. AIM: To assess the differences existing in the quantitative miRNA gene expression in HCC on tissue according to two different liver controls...
June 21, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28630591/notch-signalinio-kelio-ir-ginekologini%C3%A5-piktybini%C3%A5-navik%C3%A5-s%C3%A4-saja
#2
Nadežda Lachej, Daiva Dabkevičienė, Aušra Sasnauskienė, Rūta Marija Trimonytė, Daiva Kanopienė, Birutė Kazbarienė, Janina Didžiapetrienė
Background. The body's cell behaviour is controlled by various signalling pathways, one of which is NOTCH. It has been found that a partial loss of the NOTCH function or abnormal strengthening of NOTCH signalling are related to various human diseases and developmental disorders. Materials and methods. PubMed was the main source of information for this paper. Results. The paper overviews the association between oncologic diseases and the participants of the NOTCH signalling pathway. In cancerogenesis, the NOTCH signalling pathway can act as a tumour suppressor or an oncogene...
2017: Acta medica Lituanica
https://www.readbyqxmd.com/read/28616749/mir-183-and-mir-21-expression-as-biomarkers-of-progression-and-survival-in-tongue-carcinoma-patients
#3
Gordana Supic, Katarina Zeljic, Aleksandra Divac Rankov, Ruzica Kozomara, Aleksandra Nikolic, Dragica Radojkovic, Zvonko Magic
OBJECTIVES: Micro RNAs (miRNAs) have a major role in human cancerogenesis.The current study investigated the prognostic significance of miR-183 and miR-21 expression in tongue carcinoma patients. MATERIAL AND METHOD: For qPCR of miR-183 and miR-21 expression, total RNA isolated from 60 fresh-frozen tissue of tongue carcinomas was converted into cDNA by TaqMan MicroRNA Reverse Transcription Kit and quantified by TaqMan MicroRNAs Expression Assays. Fold changes in the miRNAs expression, normalized to RNU6B, were determined using 2(-ΔΔCt) method, and dichotomized into high and low according to cut-off values derived from ROC curve analysis...
June 14, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28612612/-molecular-aspects-of-thyroid-tumors-with-emphasis-on-microrna-and-their-clinical-implications
#4
M Ludvíková, I Kholová, D Kalfeřt
BACKGROUND: Central to neoplastic transformation and tumor progression is alteration of the signaling pathways that control cell proliferation and apoptosis. The key mechanisms for this neoplastic process are genetic changes (mutations of cancer-related genes) and recently identified epigenetic changes that involve DNA methylation, chromatin remodeling (which has a profound effect on the control of gene expression), and noncoding, regulatory RNA (notably, microRNA - miRNA). MiRNAs control expression of their target gene post-transcriptionally...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28604784/potential-therapeutic-impact-of-cd13-expression-in-non-small-cell-lung-cancer
#5
Lars Henning Schmidt, Caroline Brand, Janine Stucke-Ring, Christoph Schliemann, Torsten Kessler, Saliha Harrach, Michael Mohr, Dennis Görlich, Alessandro Marra, Ludger Hillejan, Carsten Müller-Tidow, Georg Lenz, Eva Wardelmann, Rainer Wiewrodt, Wolfgang E Berdel, Christian Schwöppe, Wolfgang Hartmann
BACKGROUND: Aminopeptidase N (CD13) is a zinc-binding protease that has functional effects on both cancerogenesis and tumor angiogenesis. Since CD13 is an antigen suitable for molecular targeted therapies (e.g. tTF-NGR induced tumor vascular infarction), we evaluated its impact in NSCLC patients, and tested the effects of the CD13-targeted fusion protein tTF-NGR (truncated tissue factor (tTF) containing the NGR motif: asparagine-glycine-arginine) in vivo in nude mice. METHODS: Expression of both CD13 and CD31 was studied in 270 NSCLC patients by immunohistochemistry...
2017: PloS One
https://www.readbyqxmd.com/read/28599991/clinical-perspective-on-diagnostic-x-ray-examinations-of-pregnant-patients-what-to-take-into-account
#6
REVIEW
Peter Vock
Imaging during pregnancy has increased in frequency. Radiation protection is extremely important although tissue reactions of the conceptus, requiring a threshold dose of around 100mGy, are unlikely in the diagnostic use of X-rays and stochastic effects of cancerogenesis have a rather low risk (around 10(-4)/mGy for childhood cancer due to in utero exposure). This article will review the risk depending on dose and phase of pregnancy and the exposure by frequent examinations; it will then concentrate on the duties of an imaging department: screening for pregnancy, examination justification, planning and optimization, patient information, counseling, involving the patient in the decisions, and managing the situation of pregnant staff members...
June 6, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28552560/2102ep-embryonal-carcinoma-cells-have-compromised-respiration-and-shifted-bioenergetic-profile-distinct-from-h9-human-embryonic-stem-cells
#7
Lyudmila Ounpuu, Aleksandr Klepinin, Martin Pook, Indrek Teino, Nadezda Peet, Kalju Paju, Kersti Tepp, Vladimir Chekulayev, Igor Shevchuk, Sulev Koks, Toivo Maimets, Tuuli Kaambre
Recent studies have shown that cellular bioenergetics may be involved in stem cell differentiation. Considering that during cancerogenesis cells acquire numerous properties of stem cells, it is possible to assume that the energy metabolism in tumorigenic cells might be differently regulated. The aim of this study was to compare the mitochondrial bioenergetic profile of normal pluripotent human embryonic stem cells (hESC) and relatively nullipotent embryonal carcinoma cells (2102Ep cell line). We examined three parameters related to cellular bioenergetics: phosphotransfer system, aerobic glycolysis, and oxygen consumption...
August 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28528692/insulin-like-growth-factor-igf-axis-in-cancerogenesis
#8
REVIEW
Aldona Kasprzak, Wojciech Kwasniewski, Agnieszka Adamek, Anna Gozdzicka-Jozefiak
Determination of the role of insulin-like growth factor (IGF) family components in carcinogenesis of several human tumors is based on numerous epidemiological and pre-clinical studies, experiments in vivo and in vitro and on attempts at application of drugs affecting the IGF axis. Investigative hypotheses in original studies were based on biological functions manifested by the entire family of IGF (ligands, receptors, linking proteins, adaptor molecules). In the context of carcinogenesis the most important functions of IGF family involve intensification of proliferation and inhibition of cell apoptosis and effect on cell transformation through synthesis of several regulatory proteins...
April 2017: Mutation Research
https://www.readbyqxmd.com/read/28504958/prognostic-value-of-dna-repair-genes-based-on-stratification-of-glioblastomas
#9
Sun Kun, Qiwen Duan, Gang Liu, Jing-Min Lu
Abnormal expression of DNA repair genes is frequently associated with cancerogenesis of many tumors, however, the role DNA repair genes play in the progression of glioblastoma remains unclear. In this study, taking advantage of large scale of RNA-seq data, as well as clinical data, the function and prognosis value of key DNA repair genes in glioblastoma were analyzed by systematically bioinformatic approaches. Clustering was performed to screen potentially abnormal DNA repair genes related to the prognosis of glioblastoma, followed by unsupervised clustering to identify molecular subtypes of glioblastomas...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28483679/sensitive-and-non-invasive-assessment-of-hepatocellular-iron-using-a-novel-room-temperature-susceptometer
#10
Johannes Mueller, Hanna Raisi, Vanessa Rausch, Teresa Peccerella, David Simons, Christian Ziener, Heinz-Peter Schlemmer, Helmut Karl Seitz, Nina Waldburger, Thomas Longerich, Beate Katharina Straub, Sebastian Mueller
PURPOSE: Liver iron accumulates in various chronic liver diseases where it is an independent factor of survival and cancerogenesis. We here tested a novel room-temperature susceptometer (RTS) to noninvasively assess liver iron concentration (LIC). MATERIALS AND METHODS: 264 patients with or without signs of iron overload or liver disease were prospectively enrolled. 35 patients underwent liver biopsy with semiquantitative iron determination (Prussian Blue staining), atomic absorption spectroscopy (AAS, n=33) or MRI (n=15)...
May 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28470968/fluorescent-diagnostics-of-epithelial-neoplasms-of-different-colon-parts
#11
Yulia S Korneva, Alexander E Dorosevich, Valeriya S Maryakhina
OBJECTIVE: Changes in the biochemical composition of the tissue during colon cancer progression usually precede morphological changes registered by light microscopy. These changes are very sensitive and may be used for diagnostics in difficult cases, when it is impossible to obtain sufficient amount of material during colonoscopy. The aim of the study is analysis of spectral characteristics of sporadic adenomas and tumors in different parts of colon for improving tumors diagnostics in disputable cases...
May 4, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28443463/decreased-expression-of-hsa_circ_0001895-in-human-gastric-cancer-and-its-clinical-significances
#12
Yongfu Shao, Linbo Chen, Rongdan Lu, Xinjun Zhang, Bingxiu Xiao, Guoliang Ye, Junming Guo
Circular RNAs are a special class of endogenous RNAs characterized by jointing 3' and 5' ends together via exon or intron circularization. Recent studies found that circular RNAs are involved in the development of some human diseases. However, little is known about their roles in human gastric cancer. In this study, we chose hsa_circ_0001895 as a targeted circRNA to investigate its clinical significances in gastric cancer patients. Hsa_circ_0001895 expression levels in five gastric cancer cell lines and 257 specimens of tissues were measured by real-time quantitative reverse transcription polymerase chain reaction...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28398662/rhesus-ce-expression-on-patient-red-blood-cells-is-an-independent-prognostic-factor-for-adenocarcinoma-of-the-lung
#13
A B Schulze, L H Schmidt, L Baie, B Heitkötter, A Kümmel, M Mohr, R Buhl, H Hillmann, G Geißler, R Kelsch, D Görlich, W E Berdel, W Hartmann, R Wiewrodt
OBJECTIVES: The influence of blood group antigens on cancerogenesis is shown for distinct tumor types, yet the impact of Rhesus blood group antigens in lung cancer is not clarified. MATERIALS AND METHODS: To investigate the impact of Rhesus blood groups a non-small cell lung cancer (NSCLC) collective (n=1,047) was analyzed retrospectively. Using a second cohort of n=340 primarily operated stage I-III NSCLC patients, we evaluated immunohistochemistry of CD47-antibody stained tissue samples in correlation to histopathologic subtype and Rhesus blood group...
April 11, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28387492/-skin-carcinogenesis-in-renal-transplant-recipients
#14
REVIEW
G E Piérard, C Piérard-Franchimont, P Delvenne
Organ transplants are bound to the induction and upkeep of immunosuppression. The immunomodulatory regimen modalities have changed over time with an improvement of the overage graft survival. The effects are also present on the skin and its cancerogenesis which is particularly activated for the squamous cell carcinoma. A review of the recent medical literature reveals the importance of searching squamous cell carcinomas, actinic keratoses, seborrheic keratoses and keratocanthomas before and after organ transplants...
March 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28315432/splicing-factors-of-sr-and-hnrnp-families-as-regulators-of-apoptosis-in-cancer
#15
Hanna Kędzierska, Agnieszka Piekiełko-Witkowska
SR and hnRNP proteins were initially discovered as regulators of alternative splicing: the process of controlled removal of introns and selective joining of exons through which multiple transcripts and, subsequently, proteins can be expressed from a single gene. Alternative splicing affects genes involved in all crucial cellular processes, including apoptosis. During cancerogenesis impaired apoptotic control facilitates survival of cells bearing molecular aberrations, contributing to their unrestricted proliferation and chemoresistance...
March 14, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28259291/epigenetic-control-of-gene-expression-potential-implications-for-cancer-treatment
#16
REVIEW
F Perri, F Longo, M Giuliano, F Sabbatino, G Favia, F Ionna, R Addeo, G Della Vittoria Scarpati, G Di Lorenzo, S Pisconti
Epigenetic changes are defined as inherited modifications that are not present in DNA sequence. Gene expression is regulated at various levels and not only in response to DNA modifications. Examples of epigenetic control are DNA methylation, histone deacetylation and mi-RNA expression. Methylation of several tumor suppressor gene promoters is responsible for their silencing and thus potentially sustain cancerogenesis. Similarly, histone deacetylation can lead to oncogene activation. mi-RNA are small (18-20 nucleotides) non-coding RNA fragments capable of inhibiting other m-RNA, ultimately altering the balance in oncogene and tumor suppressor gene expression...
March 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28212293/targeting-angiogenesis-in-biliary-tract-cancers-an-open-option
#17
REVIEW
Valeria Simone, Oronzo Brunetti, Luigi Lupo, Mario Testini, Eugenio Maiorano, Michele Simone, Vito Longo, Christian Rolfo, Marc Peeters, Aldo Scarpa, Amalia Azzariti, Antonio Russo, Domenico Ribatti, Nicola Silvestris
Biliary tract cancers (BTCs) are characterized by a bad prognosis and the armamentarium of drugs for their treatment is very poor. Although the inflammatory status of biliary tract represents the first step in the cancerogenesis, the microenvironment also plays a key role in the pathogenesis of BTCs, promoting tumor angiogenesis, invasion and metastasis. Several molecules, such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), are involved in the angiogenesis process and their expression on tumor samples has been explored as prognostic marker in both cholangiocarcinoma and gallbladder cancer...
February 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28185541/kaos-a-new-automated-computational-method-for-the-identification-of-overexpressed-genes
#18
Angelo Nuzzo, Giovanni Carapezza, Sebastiano Di Bella, Alfredo Pulvirenti, Antonella Isacchi, Roberta Bosotti
BACKGROUND: Kinase over-expression and activation as a consequence of gene amplification or gene fusion events is a well-known mechanism of tumorigenesis. The search for novel rearrangements of kinases or other druggable genes may contribute to understanding the biology of cancerogenesis, as well as lead to the identification of new candidate targets for drug discovery. However this requires the ability to query large datasets to identify rare events occurring in very small fractions (1-3 %) of different tumor subtypes...
November 8, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28172456/op027-il-33-st2-axis-sustains-gut-mucosal-wound-healing-and-cancerogenesis-in-colitis-associated-colorectal-cancer
#19
L R Lopetuso, C De Salvo, L Di Martino, W Goodman, F Scaldaferri, A Gasbarrini, T T Pizarro
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28149884/p53-mutations-and-cancer-a-tight-linkage
#20
COMMENT
Francesco Perri, Salvatore Pisconti, Giuseppina Della Vittoria Scarpati
P53 is often mutated in solid tumors, in fact, somatic changes involving the gene encoding for p53 (TP53) have been discovered in more than 50% of human malignancies and several data confirmed that p53 mutations represent an early event in cancerogenesis. Main p53 functions consist in cell cycle arrest, DNA repair, senescence and apoptosis induction in response to mutagenic stimuli, and, to exert those functions, p53 acts as transcriptional factor. Recent data have highlighted another very important role of p53, consisting in regulate cell metabolism and cell response to oxidative stress...
December 2016: Annals of Translational Medicine
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