keyword
MENU ▼
Read by QxMD icon Read
search

Replication Stress

keyword
https://www.readbyqxmd.com/read/28430968/sex-chromosome-dependent-differential-viability-of-human-spermatozoa-during-prolonged-incubation
#1
Young-Ah You, Woo-Sung Kwon, Md Saidur Rahman, Yoo-Jin Park, Young-Ju Kim, Myung-Geol Pang
STUDY QUESTION: Are there significant differences in the ability of X chromosome-bearing (X) spermatozoa and Y chromosome-bearing (Y) spermatozoa to survive incubation under stressful conditions? SUMMARY ANSWER: Y spermatozoa are more vulnerable to stress than their X counterparts depending on culture period and temperature, and show higher expression of apoptotic proteins. WHAT IS KNOWN ALREADY: The primary sex ratio is determined by there being an equal number of spermatozoa carrying X and Y chromosomes...
April 19, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28430596/snm1b-apollo-in-the-dna-damage-response-and-telomere-maintenance
#2
REVIEW
Maren Schmiester, Ilja Demuth
hSNM1B/Apollo is a member of the highly conserved β-CASP subgroup within the MBL superfamily of proteins. It interacts with several DNA repair proteins and functions within the Fanconi anemia pathway in response to DNA interstrand crosslinks. As a shelterin accessory protein, hSNM1B/Apollo is also vital for the generation and maintenance of telomeric overhangs. In this review, we will summarize studies on hSNM1B/Apollo's function, including its contribution to DNA damage signaling, replication fork maintenance, control of topological stress and telomere protection...
April 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28428950/endogenous-and-exogenous-kdpf-peptide-increases-susceptibility-of-mycobacterium-bovis-bcg-to-nitrosative-stress-and-reduces-intramacrophage-replication
#3
Mariana Rosas Olvera, Eric Vivès, Virginie Molle, Anne-Béatrice Blanc-Potard, Laila Gannoun-Zaki
Emerging antibiotic resistance in pathogenic bacteria like Mycobacterium sp., poses a threat to human health and therefore calls for the development of novel antibacterial strategies. We have recently discovered that bacterial membrane peptides, such as KdpF, possess anti-virulence properties when overproduced in pathogenic bacterial species. Overproduction of the KdpF peptide in Mycobacterium bovis BCG decreased bacterial replication within macrophages, without presenting antibacterial activity. We propose that KdpF functions as a regulatory molecule and interferes with bacterial virulence, potentially through interaction with the PDIM transporter MmpL7...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28425455/the-effect-of-hydraulic-flowback-and-produced-water-on-gill-morphology-oxidative-stress-and-antioxidant-response-in-rainbow-trout-oncorhynchus-mykiss
#4
Tamzin A Blewett, Alyssa M Weinrauch, Perrine L M Delompré, Greg G Goss
Hydraulic fracturing fluid are complex mixtures containing high concentrations of salts (up to 330,000 ppm), organic, and metal contaminants. However, little data exist on the potential mechanisms of toxicity of these flowback and produced wastewaters (FPW) on aquatic biota. Juvenile rainbow trout were exposed to either control, FPW (2.5 or 7.5%), FPW that had been treated with activated charcoal (AC), or a custom salt-matched control (SW; replicating only the salt content of FPW) for 48 hours. Gill histology revealed decreases in interlamellar cell mass (ILCM) and mean lamellar length in all treatments (FPW, AC and SW) compared to control, indicative of hyperosmotic stress...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28423056/hair-and-stress-a-pilot-study-of-hair-and-cytokine-balance-alteration-in-healthy-young-women-under-major-exam-stress
#5
Eva M J Peters, Yvonne Müller, Wenke Snaga, Herbert Fliege, Anett Reißhauer, Thomas Schmidt-Rose, Heiner Max, Dorothea Schweiger, Matthias Rose, Johannes Kruse
Mouse models show that experimental stress mimicking prolonged life-stress exposure enhances neurogenic inflammation, induces adaptive immunity cytokine-imbalance characterized by a shift to Type 1 T-helper cell cytokines and increases apoptosis of epithelial cells. This affects hair growth in otherwise healthy animals. In this study, we investigate whether a prolonged naturalistic life-stress exposure affects cytokine balance and hair parameters in healthy humans. 33 (18 exam, 15 comparison) female medical students with comparable sociobiological status were analyzed during a stressful final examination period, at three points in time (T) 12 weeks apart...
2017: PloS One
https://www.readbyqxmd.com/read/28421976/-measles-after-mmr-vaccination
#6
R van Grootveld, L M Klitsie, D C M van der Kaay, A C T M Vossen, A C Dijkmans
BACKGROUND: The Dutch national vaccination program provides vaccination for mumps, measles and rubella (MMR vaccine) for all children. After vaccination with live attenuated viruses, the virus replicates on a limited scale. Replication may lead to mild symptoms occurring 5-14 days after MMR-vaccination, including fever, conjunctivitis and rash. Symptoms are comparable to those of a wildtype measles infection. CASE DESCRIPTION: A 14-month-old boy was admitted to the hospital with an impressive rash 13 days after MMR-vaccination...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28418333/nonlinear-feedback-drives-homeostatic-plasticity-in-h2o2-stress-response
#7
Youlian Goulev, Sandrine Morlot, Audrey Matifas, Bo Huang, Mikael Molin, Michel B Toledano, Gilles Charvin
Homeostatic systems that rely on genetic regulatory networks are intrinsically limited by the transcriptional response time, which may restrict a cell's ability to adapt to unanticipated environmental challenges. To bypass this limitation, cells have evolved mechanisms whereby exposure to mild stress increases their resistance to subsequent threats. However, the mechanisms responsible for such adaptive homeostasis remain largely unknown. Here, we used live-cell imaging and microfluidics to investigate the adaptive response of budding yeast to temporally controlled H2O2 stress patterns...
April 18, 2017: ELife
https://www.readbyqxmd.com/read/28416140/ribonucleotide-reductase-requires-subunit-switching-in-hypoxia-to-maintain-dna-replication
#8
Iosifina P Foskolou, Christian Jorgensen, Katarzyna B Leszczynska, Monica M Olcina, Hanna Tarhonskaya, Bauke Haisma, Vincenzo D'Angiolella, William K Myers, Carmen Domene, Emily Flashman, Ester M Hammond
Cells exposed to hypoxia experience replication stress but do not accumulate DNA damage, suggesting sustained DNA replication. Ribonucleotide reductase (RNR) is the only enzyme capable of de novo synthesis of deoxyribonucleotide triphosphates (dNTPs). However, oxygen is an essential cofactor for mammalian RNR (RRM1/RRM2 and RRM1/RRM2B), leading us to question the source of dNTPs in hypoxia. Here, we show that the RRM1/RRM2B enzyme is capable of retaining activity in hypoxia and therefore is favored over RRM1/RRM2 in order to preserve ongoing replication and avoid the accumulation of DNA damage...
April 20, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28415748/the-spi1-pu-1-transcription-factor-accelerates-replication-fork-progression-by-increasing-pp1-phosphatase-in-leukemia
#9
Pauline Rimmelé, Michela Esposito, Laure Delestré, Jean-Hugues Guervilly, Maya Ridinger-Saison, Emmanuelle Despras, Françoise Moreau-Gachelin, Filippo Rosselli, Christel Guillouf
Oncogenes trigger replicative stress that can lead to genetic instability, which participates in cancer progression. Thus, determining how cells cope with replicative stress can help our understanding of oncogenesis and lead to the identification of new antitumor treatment targets. We previously showed that constitutive overexpression of the oncogenic transcription factor Spi1/PU.1 leads to pre-leukemic cells that have a shortened S phase duration with an increased replication fork speed and increased mutability in the absence of DNA breaks...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414320/inhibition-of-dna2-nuclease-as-a-therapeutic-strategy-targeting-replication-stress-in-cancer-cells
#10
S Kumar, X Peng, J Daley, L Yang, J Shen, N Nguyen, G Bae, H Niu, Y Peng, H-J Hsieh, L Wang, C Rao, C C Stephan, P Sung, G Ira, G Peng
Replication stress is a characteristic feature of cancer cells, which is resulted from sustained proliferative signaling induced by activation of oncogenes or loss of tumor suppressors. In cancer cells, oncogene-induced replication stress manifests as replication-associated lesions, predominantly double-strand DNA breaks (DSBs). An essential mechanism utilized by cells to repair replication-associated DSBs is homologous recombination (HR). In order to overcome replication stress and survive, cancer cells often require enhanced HR repair capacity...
April 17, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28414293/inherited-gins1-deficiency-underlies-growth-retardation-along-with-neutropenia-and-nk-cell-deficiency
#11
Julien Cottineau, Molly C Kottemann, Francis P Lach, Young-Hoon Kang, Frédéric Vély, Elissa K Deenick, Tomi Lazarov, Laure Gineau, Yi Wang, Andrea Farina, Marie Chansel, Lazaro Lorenzo, Christelle Piperoglou, Cindy S Ma, Patrick Nitschke, Aziz Belkadi, Yuval Itan, Bertrand Boisson, Fabienne Jabot-Hanin, Capucine Picard, Jacinta Bustamante, Céline Eidenschenk, Soraya Boucherit, Nathalie Aladjidi, Didier Lacombe, Pascal Barat, Waseem Qasim, Jane A Hurst, Andrew J Pollard, Holm H Uhlig, Claire Fieschi, Jean Michon, Vladimir P Bermudez, Laurent Abel, Jean-Pierre de Villartay, Frédéric Geissmann, Stuart G Tangye, Jerard Hurwitz, Eric Vivier, Jean-Laurent Casanova, Agata Smogorzewska, Emmanuelle Jouanguy
Inborn errors of DNA repair or replication underlie a variety of clinical phenotypes. We studied 5 patients from 4 kindreds, all of whom displayed intrauterine growth retardation, chronic neutropenia, and NK cell deficiency. Four of the 5 patients also had postnatal growth retardation. The association of neutropenia and NK cell deficiency, which is unusual among primary immunodeficiencies and bone marrow failures, was due to a blockade in the bone marrow and was mildly symptomatic. We discovered compound heterozygous rare mutations in Go-Ichi-Ni-San (GINS) complex subunit 1 (GINS1, also known as PSF1) in the 5 patients...
April 17, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28412652/during-yeast-chronological-aging-resveratrol-supplementation-results-in-a-short-lived-phenotype-sir2-dependent
#12
Ivan Orlandi, Giulia Stamerra, Maurizio Strippoli, Marina Vai
Resveratrol (RSV) is a naturally occurring polyphenolic compound endowed with interesting biological properties/functions amongst which are its activity as an antioxidant and as Sirtuin activating compound towards SIRT1 in mammals. Sirtuins comprise a family of NAD(+)-dependent protein deacetylases that are involved in many physiological and pathological processes including aging and age-related diseases. These enzymes are conserved across species and SIRT1 is the closest mammalian orthologue of Sir2 of Saccharomyces cerevisiae...
April 9, 2017: Redox Biology
https://www.readbyqxmd.com/read/28412252/replicative-senescence-promotes-prothrombotic-responses-in-endothelial-cells-role-of-nadph-oxidase-and-cyclooxygenase-derived-oxidative-stress
#13
Grazielle Caroline da Silva, Malak Abbas, Sonia Khemais-Benkhiat, Melanie Burban, Thais Porto Ribeiro, Florence Toti, Noureddine Idris-Khodja, Steyner F Côrtes, Valérie B Schini-Kerth
Endothelial senescence has been suggested to promote endothelial dysfunction in age-related vascular disorders. This study evaluated the prothrombotic properties of senescent endothelial cells (ECs) and the underlying mechanism. Serial passaging from passage (P)1 to P4 (replicative senescence) of porcine coronary artery ECs, or treatment of P1 ECs with the endothelial nitric oxide synthase (eNOS) inhibitor L-NAME (premature senescence) induced acquisition of markers of senescence including increased senescence-associated-β-galactosidase (SA-β-gal) activity and p53, p21, p16 expression...
April 12, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28411515/response-of-soil-microbial-activities-and-microbial-community-structure-to-vanadium-stress
#14
REVIEW
Xi-Yuan Xiao, Ming-Wei Wang, Hui-Wen Zhu, Zhao-Hui Guo, Xiao-Qing Han, Peng Zeng
High levels of vanadium (V) have long-term, hazardous impacts on soil ecosystems and biological processes. In the present study, the effects of V on soil enzymatic activities, basal respiration (BR), microbial biomass carbon (MBC), and the microbial community structure were investigated through 12-week greenhouse incubation experiments. The results showed that V content affected soil dehydrogenase activity (DHA), BR, and MBC, while urease activity (UA) was less sensitive to V stress. The average median effective concentration (EC50) thresholds of V were predicted using a log-logistic dose-response model, and they were 362mgV/kg soil for BR and 417mgV/kg soil for DHA...
April 12, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28409385/the-effect-of-dietary-folic-acid-on-biochemical-parameters-and-gene-expression-of-three-heat-shock-proteins-hsps-of-blunt-snout-bream-megalobrama-amblycephala-fingerling-under-acute-high-temperature-stress
#15
Daniella Fatmata Sesay, Habte-Michael Habte-Tsion, Qunlan Zhou, Mingchun Ren, Jun Xie, Bo Liu, Ruli Chen, Liangkun Pan
The effects of dietary folic acid on biochemical parameters and gene expression of three heat shock proteins (HSPs) of blunt snout bream (Megalobrama amblycephala) fingerling under acute high temperature stress. Six dietary folic acid groups (0.0, 0.5, 1.0, 2.0, 5.0, and 10.0) mg/kg diets were designed and assigned into 18 tanks in three replicates each (300 l/tank) and were administered for 10 weeks in a re-circulated water system. The fingerlings with an initial weight of 27.0 ± 0.03 g were fed with their respective diets four times daily...
April 13, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28407539/the-single-and-joint-toxicity-effects-of-chlorpyrifos-and-beta-cypermethrin-in-zebrafish-danio-rerio-early-life-stages
#16
Jiayu Zhang, Lili Liu, Lei Ren, Weimin Feng, Peng Lv, Wei Wu, Yanchun Yan
Water environment pollution caused by the widespread application of beta-cypermethrin (BCP) and chlorpyrifos (CPF) in agriculture has attracted extensive concern of the world. In this study, zebrafish was used as a model to investigate the individual and joint toxicity of BCP and CPF. In the acute toxicity test, 3 hpf embryos were exposed to various concentrations of CPF, BCP and their binary mixtures (MIX) for 96h. The results indicated that these two pesticides and mixtures induced malformation and death in larvae, and affected hatchability...
March 27, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28407508/stress-related-telomere-length-in-children-a-systematic-review
#17
REVIEW
Bruno Messina Coimbra, Carolina Muniz Carvalho, Patricia Natalia Moretti, Marcelo Feijó Mello, Sintia I Belangero
Telomeres are repetitive DNA sequences at the ends of chromatids that shorten following each cell replication. Once telomeres reach a critical length, DNA defense mechanisms can direct cells to either a state of arrest (senescence) or apoptosis. Stress induced by adversity is a probable cause of accelerated telomere shortening from an early age. However, few studies have examined the association between stress and telomere length in children, and it remains unclear whether young individuals may show signs of cellular aging early in life...
April 2, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28406523/exposure-to-extrinsic-stressors-social-defeat-or-bisphenol-a-eliminates-sex-differences-in-dna-methyltransferase-expression-in-the-amygdala
#18
Emily C Wright, Sarah A Johnson, Rebecca Hao, Alex S Kowalczyk, Gian D Greenberg, Evelyn Ordoñes Sanchez, Abigail Laman-Maharg, Brian C Trainor, Cheryl S Rosenfeld
Chemical and psychological stressors can exert long lasting changes in brain function and behavior. Changes in DNA methylation have been shown to be an important mechanism mediating long lasting changes in neural function and behavior, especially for anxiety-like or stress responses. Here we examined the effects of either a social or chemical stressor on DNA methyltransferase (DNMT) gene expression in the amygdala, an important brain region modulating stress responses and anxiety. In adult California mice (Peromyscus californicus) that were naïve to social defeat, females had higher levels of Dnmt1 expression in punch samples of the central amygdala (CeA) than males...
April 12, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28406444/identification-of-drought-responsive-micrornas-from-roots-and-leaves-of-alfalfa-by-high-throughput-sequencing
#19
Yue Li, Liqiang Wan, Shuyi Bi, Xiufu Wan, Zhenyi Li, Jing Cao, Zongyong Tong, Hongyu Xu, Feng He, Xianglin Li
Alfalfa, an important forage legume, is an ideal crop for sustainable agriculture and a potential crop for bioenergy resources. Drought, one of the most common environmental stresses, substantially affects plant growth, development, and productivity. MicroRNAs (miRNAs) are newly discovered gene expression regulators that have been linked to several plant stress responses. To elucidate the role of miRNAs in drought stress regulation of alfalfa, a high-throughput sequencing approach was used to analyze 12 small RNA libraries comprising of four samples, each with three biological replicates...
April 13, 2017: Genes
https://www.readbyqxmd.com/read/28405465/effect-of-the-needle-free-intra-dermal-application-of-liquids-vaccination-on-the-welfare-of-pregnant-sows
#20
Déborah Temple, Damián Escribano, Marta Jiménez, Eva Mainau, José J Cerón, Xavier Manteca
BACKGROUND: In commercial pig production, sows are often vaccinated several times per gestation period, resulting in reduced welfare. This preliminary experiment investigated whether the needle-free IDAL vaccinator improves welfare through reduction of stress markers, improvement of behavioural and health parameters compared to traditional needle-syringe method. RESULTS: Two treatments (IDAL and NEEDLE) in 6 replicate pens of gestating sows (15 sows per pen) were evaluated using Porcilis® PRRS...
2017: Porcine Health Management
keyword
keyword
60291
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"