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https://www.readbyqxmd.com/read/26796995/association-of-toll-like-receptor-3-polymorphism-rs3775291-with-age-related-macular-degeneration-a-systematic-review-and-meta-analysis
#1
Li Ma, Fang Yao Tang, Wai Kit Chu, Alvin L Young, Marten E Brelen, Chi Pui Pang, Li Jia Chen
Association of a polymorphism rs3775291 in the toll-like receptor 3 (TLR3) gene with age-related macular degeneration (AMD) had been investigated intensively, with variable results across studies. Here we conducted a meta-analysis to verify the effect of rs3775291 on AMD. We searched for genetic association studies published in PubMed, EMBASE and Web of Science from start dates to March 10, 2015. Totally 235 reports were retrieved and 9 studies were included for meta-analysis, involving 7400 cases and 13579 controls...
2016: Scientific Reports
https://www.readbyqxmd.com/read/19091857/predicting-the-impact-of-blocking-human-immunodeficiency-virus-type-1-nef-in-vivo
#2
W David Wick, Peter B Gilbert, Otto O Yang
Human immunodeficiency virus type 1 (HIV-1) Nef is a multifunctional protein that confers an ability to evade killing by cytotoxic T lymphocytes (CTLs) as well as other advantages to the virus in vivo. Here we exploited mathematical modeling and related statistical methods to estimate the impact of Nef activity on viral replication in vivo in relation to CTLs. Our results indicate that downregulation of major histocompatibility complex class I (MHC-I) A and B by wild-type Nef confers an advantage to the virus of about 82% in decreased CTL killing efficiency on average, meaning that abolishing the MHC-I downregulation function of Nef would increase killing by more than fivefold...
March 2009: Journal of Virology
https://www.readbyqxmd.com/read/12963084/nr2b-subunit-selective-nmda-antagonists-inhibit-neurotoxic-effect-of-alcohol-withdrawal-in-primary-cultures-of-rat-cortical-neurones
#3
József Nagy, Csilla Horváth, Sándor Farkas, Sándor Kolok, Zsolt Szombathelyi
N-Methyl-D-aspartate (NMDA) receptor-mediated glutamatergic neurotransmission is thought to play a central role in the development of alcohol dependence and this alteration is supposed to be due to a differential up-regulation of the NR2B type of subunits. In this work, we examined the effect of some known (CP-101,606; CI-1041 and Co-101,244) and novel indole-2-carboxamide derivative NR2B subunit selective NMDA receptor antagonists (SSNAs) (RG-13579 and RG-1103) on the neurotoxic effect of withdrawal in ethanol pre-treated cultures of rat cortical neurones...
January 2004: Neurochemistry International
https://www.readbyqxmd.com/read/10380355/the-human-mucus-protease-inhibitor-and-its-mutants-are-novel-defensive-compounds-against-infection-with-influenza-a-and-sendai-viruses
#4
H Kido, Y Beppu, Y Imamura, Y Chen, M Murakami, K Oba, T Towatari
Tryptase Clara, a trypsin-like protease localized exclusively in and secreted by Clara cells of the bronchial epithelium, is a prime host factor that processes viral envelope glycoproteins and determines the infectivity of influenza A and Sendai viruses (H. Kido, Y. Yokogoshi, K. Sakai, M. Tashiro, Y. Kishino, A. Fukutomi, and N. Katunuma, The Journal of Biological Chemistry, 1992, Vol. 267, pp. 13573-13579). We report here that human mucus protease inhibitor (MPI), a major inhibitor of granulocyte elastase in the lining fluid of the human respiratory tract, significantly inhibited induction of the infectivity of influenza A and Sendai viruses by tryptase Clara in vitro and multicycles of mouse-adapted influenza A virus replication in rat lungs in vivo...
1999: Biopolymers
https://www.readbyqxmd.com/read/9735938/nutritional-status-of-children-admitted-to-hospital-with-different-diseases-and-its-relationship-to-outcome-in-the-gambia-west-africa
#5
MULTICENTER STUDY
W D Man, M Weber, A Palmer, G Schneider, R Wadda, S Jaffar, E K Mulholland, B M Greenwood
Admission records from two paediatric units in The Gambia were used to explore the relationship between admission weight and different diseases. In total 13579 hospitalized children were analysed. For comparison, 7399 children were recruited from several surveys of well subjects to provide anthropometric values for healthy Gambian children. Compared to the control children, mean admission weights were lower for malaria (weight for age z-score: -1.602), cerebral malaria (-1.547), transfused malarial anaemia (-1...
August 1998: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/9089405/human-mucus-protease-inhibitor-in-airway-fluids-is-a-potential-defensive-compound-against-infection-with-influenza-a-and-sendai-viruses
#6
Y Beppu, Y Imamura, M Tashiro, T Towatari, H Ariga, H Kido
Tryptase Clara, a trypsin-like protease localized exclusively in and secreted from Clara cells to the bronchial epithelium of rat, proteolytically activates the infectivity of influenza A virus [H. Kido, Y. Yokogoshi, K. Sakai, M. Tashiro, Y. Kishino, A. Fukutomi, and N. Katunuma (1992) J. Biol. Chem. 267, 13573-13579]. We report here that human mucus protease inhibitor (MPI), a major inhibitor of granulocyte elastase in the lining fluids of the human respiratory tract, significantly inhibited proteolytic activation of the infectivity of influenza A and Sendai viruses by tryptase Clara in vitro and multi-cycles of mouse-adapted influenza A virus replication in rat lungs in vitro...
February 1997: Journal of Biochemistry
https://www.readbyqxmd.com/read/8639674/characterization-of-the-p68-p58-heterodimer-of-human-immunodeficiency-virus-type-2-reverse-transcriptase
#7
N Fan, K B Rank, S M Poppe, W G Tarpley, S K Sharma
Recently we demonstrated that the p58 subunit of p68/p58 HIV-2 reverse transcriptase (RT) heterodimer, produced by processing of p68/p68 homodimer with recombinant HIV-2 protease, terminates at Met484 [Fan, N., et al. (1995) J. Biol. Chem. 270, 13573-13579]. Here we describe purification and characterization of the p68/p58 heterodimer of recombinant HIV-2 RT. It exhibited both RT and RNase H activities, obeyed Michaelis-Menten kinetics, and was competitively inhibited by the DNA chain terminator ddTTP (Ki[app] = 305 +/- 20 nM)...
February 13, 1996: Biochemistry
https://www.readbyqxmd.com/read/4008482/purification-of-the-muscarinic-acetylcholine-receptor-from-porcine-brain
#8
K Haga, T Haga
The muscarinic acetylcholine receptor of porcine cerebrum has been purified to apparent homogeneity by affinity chromatography, with conjugated 3-(2'-aminobenzhydryloxy)tropane (ABT) as described previously (Haga, K., and Haga, T. (1983) J. Biol. Chem. 258, 13575-13579). In a single step purification using 900 ml of digitonin/cholate-solubilized preparations and 300 ml of the ABT-agarose gel, we obtained, in a yield of 10-15%, more than 250 pmol of muscarinic receptors which bind [3H]N-methylscopolamine with a specific activity of 1,000-5,000 pmol/mg of protein (1,000-5,000-fold purification)...
July 5, 1985: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/3745197/phosphorylation-of-the-cardiac-muscarinic-receptor-in-intact-chick-heart-and-its-regulation-by-a-muscarinic-agonist
#9
M M Kwatra, M M Hosey
We have tested the possibility that regulation of cardiac muscarinic receptor function may involve receptor phosphorylation. Chick heart muscarinic receptors were purified from relatively small amounts of tissue to near homogeneity using a three-step chromatographic procedure that utilized the affinity chromatography procedure of Haga and Haga (Haga, K., and Haga, T. (1983) J. Biol. Chem. 258, 13575-13579). The purified preparations contained a single major peptide which migrated on sodium dodecyl sulfate gels with an apparent Mr of 79,000...
September 25, 1986: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/1331518/tryptase-clara-an-activating-protease-for-sendai-virus-in-rat-lungs-is-involved-in-pneumopathogenicity
#10
M Tashiro, Y Yokogoshi, K Tobita, J T Seto, R Rott, H Kido
Tryptase Clara is an arginine-specific serine protease localized exclusively in and secreted from Clara cells of the bronchial epithelium of rats (H. Kido, Y. Yokogoshi, K. Sakai, M. Tashiro, Y. Kishino, A. Fukutomi, and N. Katunuma, J. Biol. Chem. 267:13573-13579, 1992). The purified protease was shown in vitro to behave similarly to trypsin, cleaving the precursor glycoprotein F of Sendai virus at residue Arg-116 and activating viral infectivity in a dose-dependent manner. Anti-tryptase Clara antibody inhibited viral activation by the protease in vitro in lung block cultures and in vivo in infected rats...
December 1992: Journal of Virology
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