keyword
MENU ▼
Read by QxMD icon Read
search

ARF

keyword
https://www.readbyqxmd.com/read/29473209/bendamustine-based-conditioning-prior-to-asct-results-of-a-french-multicenter-study-of-474-patients-from-lysa-centers
#1
Sylvain P Chantepie, Sylvain Garciaz, Emmanuelle Tchernonog, Frederic Peyrade, Marie-Virginie Larcher, Momar Diouf, Luc Mathieu Fornecker, Roch Houot, Thomas Gastinne, Carole Soussain, Sandra Malak, Richard Lemal, Caroline Delette, Ahmad Ibrahim, Anne-Claire Gac, E Reboursière, Jean-Pierre Vilque, Mohamed Amine Bekadja, Rene-Olivier Casasnovas, Remy Gressin, Stéphanie Guidez, Diane Coso, Charles Herbaux, Krimo Bouabdallah, Eric Durot, Gandhi Damaj
Carmustine shortage has led to an increase use of alternative conditioning regimens prior to autologous stem cell transplantation for the treatment of lymphoma, including Bendamustine-based (BeEAM). The aim of this study was to evaluate the safety of the BeEAM regimen in a large cohort of patients. A total of 474 patients with a median age of 56 years were analyzed. The majority of patients had diffuse large B-cell lymphoma (43.5%). Bendamustine was administered at a median dose of 197 mg/m2 /day (50-250) on days -7 and -6...
February 23, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29471422/phylogenetic-analysis-of-histoplasma-capsulatum-var-duboisii-in-baboons-from-archived-formalin-fixed-paraffin-embedded-tissues
#2
M Hensel, A Rodrigues Hoffmann, M Gonzales, M A Owston, E J Dick
Histoplasma capsulatum var. duboisii (Hcd) infections have been well documented to cause chronic granulomatous disease, mainly involving the skin of baboons and humans in African countries primarily. This retrospective study classified the subspecies of Histoplasma and developed a phylogenetic tree utilizing DNA sequences extracted from formalin-fixed, paraffin embedded (FFPE) tissues from 9 baboons from a research colony in Texas histologically diagnosed with Hcd. Based on sequence analysis of ITS-2, Tub-1, and ARF, Hcd isolated from the archived samples closely aligns with the African clade and has 88% sequence homology with a sample isolated from an individual in Senegal...
February 16, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29467256/commonly-used-trafficking-blocks-disrupt-arf1-activation-and-the-localization-and-function-of-specific-golgi-proteins
#3
Catherine E Gilbert, Elizabeth Sztul, Carolyn E Machamer
ADP-ribosylation factor (ARF) proteins are key regulators of the secretory pathway. ARF1, through interacting with its effectors, regulates protein trafficking by facilitating numerous events at the Golgi. One unique ARF1 effector is golgin-160, which promotes the trafficking of only a specific subset of cargo proteins through the Golgi. While studying this role of golgin-160, we discovered that commonly used cold temperature blocks utilized to synchronize cargo trafficking (20°C and 16°C) caused golgin-160 dispersal from Golgi membranes...
February 21, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29465355/functional-characterisation-of-adp-ribosylation-factor-like-protein-15-in-rheumatoid-arthritis-synovial-fibroblasts
#4
Sujit Kashyap, Uma Kumar, Anuj Kumar Pandey, Maumita Kanjilal, Patralika Chattopadhyay, Chandrashekhar Yadav, B K Thelma
OBJECTIVES: ARL15 is a novel susceptibility gene identified in a recent GWAS in a north Indian rheumatoid arthritis (RA) cohort. However, the role of ARL15 or ARF family genes in RA aetiology remains unknown. Therefore, we aimed to i) establish the expression of ARL15 in rheumatoid arthritis synovial fibroblasts (RASF) and ii) its functional characterisation by assessing its effects on major inflammatory cytokines and interacting partners using a knockdown approach. METHODS: RASF were cultured from synovial tissue obtained from RA patients (n=5) and osteoarthritis (OA) patients (n=3) serving as controls...
February 14, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29465202/-lung-ultrasound-in-patients-with-hematological-malignancies-and-acute-respiratory-failure-due-to-pneumonia
#5
V A Novikov, G M Galstyan, I An E G Gemdzh, I E Kostina, M K Gitis
PURPOSE: To compare the accuracy of bedside lung ultrasound (LUS) and chest computed tomography (CT) for the de- tection of lung lesions in patients with hematological malignancies and acute respiratory failure (ARF). MATERIALS AND METHODS: 39 patients with hematological malignancies and ARF were enrolled in prospective study. The investigation of the patients included LUS, chest C, extravascular lung water index (EVLW) by transpulmonary ther- modilution, and bronchoalveolar lavage (BAL)...
September 2017: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/29458338/association-of-matrix-metalloprotease-1-3-and-12-polymorphisms-with-rheumatic-heart-disease-in-a-chinese-han-population
#6
Wei Hu, Yujia Ye, Yirui Yin, Peng Sang, Linhua Li, Jing Wang, Wen Wan, Rui Li, Xiangfeng Bai, Yuehui Xie, Zhaohui Meng
BACKGROUND: Rheumatic heart disease (RHD) is an autoimmune disease triggered by acute rheumatic fever (ARF). Matrix metalloproteinases (MMPs) play an important role in the modulation of immune responses. The purpose of this study was to evaluate the association of MMP1, 3, and 12 promoter polymorphisms with RHD in a Han population in Southern China since the 3 genes are localized on the same chromosome and have a combined effect. METHODS: DNA samples were obtained from 90 adult patients with RHD and 90 control subjects...
February 20, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29456098/arf-excimer-laser-debrides-burns-without-destruction-of-viable-tissue-a-pilot-study
#7
Atulya Prasad, Katarzyna M Sawicka, Kelly B Pablo, Lauren K Macri, Jerome Felsenstein, James J Wynne, Richard A F Clark
INTRODUCTION: Recent evidence indicates that early removal of eschar by tangential debridement can promote healing. Laser debridement can be used for debridement of areas that prove challenging for debridement using tangential excision. In particular, irradiation with an ArF excimer laser ablates desiccated eschar and is self-terminating, preserving hydrated or viable tissue. METHODS: Thermal burns were created on the flanks of two outbred, female Yorkshire pigs using aluminum bars heated to 70°C and applied for different lengths of time...
February 15, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29453249/hhex-induces-promyelocyte-self-renewal-and-cooperates-with-growth-factor-independence-to-cause-myeloid-leukemia-in-mice
#8
Jacob T Jackson, Ashley P Ng, Benjamin J Shields, Sue Haupt, Ygal Haupt, Matthew P McCormack
The hematopoietically expressed homeobox (Hhex) transcription factor is overexpressed in human myeloid leukemias. Conditional knockout models of murine acute myeloid leukemia indicate that Hhex maintains leukemia stem cell self-renewal by enabling Polycomb-mediated epigenetic repression of the Cdkn2a tumor suppressor locus, encoding p16 Ink4a and p19 Arf However, whether Hhex overexpression also affects hematopoietic differentiation is unknown. To study this, we retrovirally overexpressed Hhex in hematopoietic progenitors...
February 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/29452030/comparative-phylogenetic-and-expression-analysis-of-small-gtpases-families-in-legume-and-non-legume-plants
#9
Ana Claudia Flores, Virginia Dalla Via, Virginia Savy, Ulises Mancini Villagra, María Eugenia Zanetti, Flavio Blanco
BACKGROUND: Small monomeric GTPases act as molecular switches in several processes that involve polar cell growth, participating mainly in vesicle trafficking and cytoskeleton rearrangements. This gene superfamily has largely expanded in plants through evolution as compared with other Kingdoms, leading to the suggestion that members of each subfamily might have acquired new functions associated to plant-specific processes. Legume plants engage in a nitrogen-fixing symbiotic interaction with rhizobia in a process that involves polar growth processes associated with the infection throughout the root hair...
February 16, 2018: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/29451891/association-of-an-intact-e2-gene-with-higher-hpv-viral-load-higher-viral-oncogene-expression-and-improved-clinical-outcome-in-hpv16-positive-head-and-neck-squamous-cell-carcinoma
#10
Nicole V Anayannis, Nicolas F Schlecht, Miriam Ben-Dayan, Richard V Smith, Thomas J Belbin, Thomas J Ow, Duk M Blakaj, Robert D Burk, Sarah M Leonard, Ciaran B Woodman, Joanna L Parish, Michael B Prystowsky
To assess the relationship of E2 gene disruption with viral gene expression and clinical outcome in human papillomavirus (HPV) positive head and neck squamous cell carcinoma, we evaluated 31 oropharyngeal and 17 non-oropharyngeal HPV16 positive carcinomas using two PCR-based methods to test for disruption of E2, followed by Sanger sequencing. Expression of HPV16 E6, E7 and E2 transcripts, along with cellular ARF and INK4A, were also assessed by RT-qPCR. Associations between E2 disruption, E2/E6/E7 expression, and clinical outcome were evaluated by Kaplan-Meier analysis for loco-regional recurrence and disease-specific survival...
2018: PloS One
https://www.readbyqxmd.com/read/29449322/actin-retrograde-flow-controls-natural-killer-cell-response-by-regulating-the-conformation-state-of-shp-1
#11
Omri Matalon, Aviad Ben-Shmuel, Jessica Kivelevitz, Batel Sabag, Sophia Fried, Noah Joseph, Elad Noy, Guy Biber, Mira Barda-Saad
Natural killer (NK) cells are a powerful weapon against viral infections and tumor growth. Although the actin-myosin (actomyosin) cytoskeleton is crucial for a variety of cellular processes, the role of mechanotransduction, the conversion of actomyosin mechanical forces into signaling cascades, was never explored in NK cells. Here, we demonstrate that actomyosin retrograde flow (ARF) controls the immune response of primary human NK cells through a novel interaction between β-actin and the SH2-domain-containing protein tyrosine phosphatase-1 (SHP-1), converting its conformation state, and thereby regulating NK cell cytotoxicity...
February 15, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29445121/tomato-auxin-response-factor-5-regulates-fruit-set-and-development-via-the-mediation-of-auxin-and-gibberellin-signaling
#12
Songyu Liu, Youwei Zhang, Qiushuo Feng, Li Qin, Changtian Pan, Anthony Tumbeh Lamin-Samu, Gang Lu
Auxin response factors (ARFs) encode transcriptional factors that function in the regulation of plant development processes. A tomato ARF gene, SlARF5, was observed to be expressed at high levels in emasculated ovaries but maintained low expression levels in pollinated ovaries. The amiRNA SlARF5 lines exhibited ovary growth and formed seedless fruits following emasculation. These parthenocarpic fruits developed fewer locular tissues, and the fruit size and weight were decreased in transgenic lines compared to those of wild-type fruits...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29443553/highly-conserved-motifs-within-the-large-sec7-arf-guanine-nucleotide-exchange-factor-gbf1-target-it-to-the-golgi-and-are-critical-for-gbf1-activity
#13
Cristian A Pocognoni, Ekaterina G Viktorova, John Wright, Justyna M Meissner, Garrett Sager, Eunjoo Lee, George A Belov, Elizabeth Sztul
Cellular life requires the activation of the ADP-ribosylation factors (ARFs) by GBF1, a guanine nucleotide exchange factor (GEF) with a highly conserved catalytic Sec7 domain (Sec7d). In addition to the Sec7d, GBF1 contains other conserved domains whose functions remain unclear. Here, we focus on HDS2 (homology downstream of the Sec7d 2) domain because the L1246R substitution within the HDS2 α-helix 5 of the zebrafish GBF1 ortholog causes vascular hemorrhaging and embryonic lethality (13). To dissect the structure/function relationships within HDS2, we generated six variants, in which the most conserved residues within α-helices 1, 2, 4 and 6 were mutated to alanines...
February 14, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29442387/scabies-is-strongly-associated-with-acute-rheumatic-fever-in-a-cohort-study-of-auckland-children
#14
Simon Thornley, Roger Marshall, Paul Jarrett, Gerhard Sundborn, Edwin Reynolds, Grant Schofield
AIM: This study sought to determine whether scabies infection is associated with acute rheumatic fever (ARF) or chronic rheumatic heart disease (CRHD). METHODS: A cohort study was undertaken using health records of children aged 3-12 years attending an oral health service for the first time. Subjects were then linked to hospital diagnoses of scabies and ARF or CRHD. RESULTS: A total of 213 957 children free of rheumatic heart disease at baseline were available for analysis...
February 14, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29441989/modulated-function-of-multidrug-resistance-associated-proteins-in-cisplatin-induced-acute-renal-failure-rats
#15
A Matsushima, K Oda, N Mori, T Murakami
The effect of cisplatin-induced acute renal failure (ARF) on the function and expression of multidrug resistanceassociated proteins (MRPs) was evaluated in rats. Rats received an intraperitoneal injection of cisplatin (9 mg/kg), and the induction of ARF state with high plasma concentrations of indoxyl sulfate and creatinine was observed 72 h after cisplatin treatment. The function of MRPs in the liver, kidney and brain was evaluated by measuring the tissue accumulation and biliary excretion of 2,4-dintrophenyl-S-glutathione (DNP-SG), a substrate for MRPs, after administration of 1-chloro-2,4-dintrobenzene (CDNB), a precursor of DNP-SG, in rats...
April 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441205/sphingosine-kinase-2-supports-the-development-of-bcr-abl-independent-acute-lymphoblastic-leukemia-in-mice
#16
Vicki Xie, Daochen Tong, Craig T Wallington-Beddoe, Ken F Bradstock, Linda J Bendall
Background: Sphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the development of acute lymphoblastic leukemia (ALL). Methods: In this and our previous study we use mouse models: in the previous study the disease was driven by the proto-oncogene BCR/ABL1, while in this study cancer risk was elevated by deletion of the tumor suppressor ARF...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29432593/selective-difficulties-in-lexical-retrieval-and-nonverbal-executive-functioning-in-children-with-hbss-sickle-cell-disease
#17
Barbara Arfé, Maria Montanaro, Elena Mottura, Michele Scaltritti, Renzo Manara, Giuseppe Basso, Laura Sainati, Raffaella Colombatti
Language deficits in multilingual children with sickle cell disease (SCD) are poorly understood. We tested the hypothesis that selective language deficits in this population could relate to an impaired frontal lobe functioning often associated with high-risk homozygous HbS disease (HbSS). In all, 32 children from immigrant communities with HbSS SCD aged 6 to 12 years (mean age = 9.03, n = 9 with silent infarcts) and 35 demographically matched healthy controls (mean age = 9.14) were tested on their naming skills, phonological and semantic fluency, attention, and selected executive functions (response inhibition and planning skills)...
February 8, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29430827/solution-structure-of-the-phd-finger-from-the-human-kiaa1045-protein
#18
Kazuhide Miyamoto, Ayumi Yamashita, Kazuki Saito
Cross-brace structural motifs are required as a scaffold to design artificial RING fingers (ARFs) that function as ubiquitin ligase (E3) in ubiquitination and have specific ubiquitin-conjugating enzyme (E2)-binding capabilities. The Simple Modular Architecture Research Tool database predicted the amino acid sequence 131-190 (KIAA1045ZF) of the human KIAA1045 protein as an unidentified structural region. Herein, the stoichiometry of zinc ions estimated spectrophotometrically by the metallochromic indicator revealed that the KIAA1045ZF motif binds to two zinc atoms...
February 12, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29426584/non-invasive-ventilation-in-children-and-adults-in-low-and-low-middle-income-countries-a-systematic-review-and-meta-analysis
#19
Keren Mandelzweig, Aleksandra Leligdowicz, Srinivas Murthy, Rejani Lalitha, Robert A Fowler, Neill K J Adhikari
PURPOSE: We systematically reviewed the effects of NIV for acute respiratory failure (ARF) in low- and low-middle income countries. MATERIALS AND METHODS: We searched MEDLINE, CENTRAL, and EMBASE (to January 2016) for observational studies and trials of NIV for ARF or in the peri-extubation period in adults and post-neonatal children. We abstracted outcomes data and assessed quality. Meta-analyses used random-effect models. RESULTS: Fifty-four studies (ten pediatric/n=1099; 44 adult/n=2904), mostly South Asian, were included...
January 12, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29424565/the-plusoptix-photoscreener-and-the-retinomax-autorefractor-as-community-based-screening-devices-for-preschool-children
#20
Michael Kinori, Iliana Molina, Eric O Hernandez, Shira L Robbins, David B Granet, Anne L Coleman, Stuart I Brown
PURPOSE: To compare the performance of the PlusoptiX S12 mobile photoscreener and the Retinomax K+3 Autorefractor as screening devices in preschool children. METHODS: Children ranging from 3 to 5 years of age from 11 San Diego County preschools underwent vision screening in their schools where ambient light could not always be controlled using both the Retinomax and the PlusoptiX. Cycloplegic refraction on the consented children was subsequently performed on the UCSD EyeMobile for children on-site at the school locations...
February 9, 2018: Current Eye Research
keyword
keyword
60282
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"