keyword
https://read.qxmd.com/read/36437553/research-progress-of-chinese-medicine-in-the-treatment-of-myocardial-ischemia-reperfusion-injury
#21
JOURNAL ARTICLE
Li Dong, Zhijie Shen, Hao Chi, Yingjie Wang, Zhaofeng Shi, Hongjun Fang, Yanling Yang, Jingfeng Rong
Vascular recanalization is the essential procedure in which severe coronary artery stenosis is diagnosed. However, the blood flow recovery associated with this procedure may cause myocardial ischemia-reperfusion injury (MIRI), which aggravates heart failure. Unfortunately, the mechanism of MIRI has historically been poorly understood. As we now know, calcium overloading, oxidative stress, mitochondrial dysfunction, inflammatory responses, and ferroptosis take part in the process of MIRI. Modern medicine has shown through clinical studies its own limited effects in the case of MIRI, whereas Chinese traditional medicine demonstrates a strong vitality...
November 28, 2022: American Journal of Chinese Medicine
https://read.qxmd.com/read/36426223/case-report-genomic-screening-for-inherited-cardiac-conditions-in-ecuadorian-mestizo-relatives-improving-familial-diagnose
#22
Santiago Cadena-Ullauri, Patricia Guevara-Ramirez, Viviana Ruiz-Pozo, Rafael Tamayo-Trujillo, Elius Paz-Cruz, Tatiana Sánchez Insuasty, Nieves Doménech, Adriana Alexandra Ibarra-Rodríguez, Ana Karina Zambrano
INTRODUCTION: Genomic screening is an informative and helpful tool for the clinical management of inherited conditions such as cardiac diseases. Cardiac-inherited diseases are a group of disorders affecting the heart, its system, function, and vasculature. Among the cardiac inherited abnormalities, one of the most common is Wolff-Parkinson-White syndrome. Similarly, hypertrophic cardiomyopathy is another common autosomal dominant inherited cardiac disease. Hypertrophic cardiomyopathy is associated with an increased incidence of Wolff-Parkinson-White syndrome; reports have suggested that it could be caused by a mutation in the protein-coding gene PRKAG2, which encodes a subunit of the AMP-activated protein kinase...
2022: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/36335106/prevalence-incidence-and-mortality-of-hypertrophic-cardiomyopathy-based-on-a-population-cohort-of-21-9-million-in-china
#23
JOURNAL ARTICLE
Ying Bai, Jian-Peng Zheng, Feng Lu, Xi-Lin Zhang, Chang-Ping Sun, Wei-Hua Guo, Yi-Xi Zou, Gregory Y H Lip, Xu-Bo Shi
There are limited studies on the prevalence and incidence of clinically diagnosed hypertrophic myocardiopathy (HCM) and its mortality in the Chinese population, and the projected population burden of HCM over the next decades. We collected data on HCM and its mortality from the Beijing Municipal Health Commission Information Center (BMHCIC) database and estimated the prevalence and incidence based on the whole Beijing population. Calculation of population trends was performed using annual percentage change (APC) and average annual percentage change (AAPC)...
November 5, 2022: Scientific Reports
https://read.qxmd.com/read/36330522/photoactivated-adenylyl-cyclases-attenuate-sepsis-induced-cardiomyopathy-by-suppressing-macrophage-mediated-inflammation
#24
JOURNAL ARTICLE
Guofang Xia, Hongyu Shi, Yuanyuan Su, Beibei Han, Chengxing Shen, Shiqiang Gao, Zhong Chen, Congfeng Xu
Sepsis-induced myocardiopathy, characterized by innate immune cells infiltration and proinflammatory cytokines release, may lead to perfusion failure or even life-threatening cardiogenic shock. Macrophages-mediated inflammation has been shown to contribute to sepsis-induced myocardiopathy. In the current study, we introduced two photoactivated adenylyl cyclases (PACs), Beggiatoa sp. PAC (bPAC) and Beggiatoa sp. IS2 PAC (biPAC) into macrophages by transfection to detect the effects of light-induced regulation of macrophage pro-inflammatory response and LPS-induced sepsis-induced myocardiopathy...
2022: Frontiers in Immunology
https://read.qxmd.com/read/36277157/thymoquinone%C3%A2-induced-autophagy-mitigates-doxorubicin%C3%A2-induced-h9c2-cell-apoptosis
#25
JOURNAL ARTICLE
Dawei Liu, Lei Zhao
Doxorubicin (Dox)-induced myocardiopathy is a massive obstacle in administering chemotherapeutic drugs in cancer patients. In the present study, the effects of thymoquinone (TQ) on Dox-induced cardiotoxicity were investigated in vitro . H9c2 cardiomyocytes were pre-treated with TQ followed by Dox, and cell viability and cell death were subsequently measured. Flow cytometry was conducted to evaluate the apoptosis of H9c2 cells. Autophagy was assessed by immunofluorescence LC3 staining. Western blot analysis was performed to determine autophagy-, apoptosis- and LKB1/AMPK-related proteins...
November 2022: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/36246499/a-rare-case-of-iatrogenic-inverted-stress-cardiomyopathy
#26
Parviz-Ali Lotfian, Arun Umesh Mahtani, Seyed Zaidi, Richard Grodman
We discuss a case of a 42-year-old female who was admitted for chronic intractable lower back pain requiring elective spinal surgery. Postoperatively, she experienced chest pressure and abdominal pain with a notable elevation in cardiac markers. A cardiac catheterization and left ventriculogram revealed normal coronary arteries and basal anterolateral hypokinesis, with the normal movement of the distal segment of the anterior wall. A rare variant of stress cardiomyopathy was diagnosed.
2022: Methodist DeBakey Cardiovascular Journal
https://read.qxmd.com/read/36160853/electroacupuncture-pre-treatment-alleviates-sepsis-induced-cardiac-inflammation-and-dysfunction-by-inhibiting-the-calpain-2-stat3-pathway
#27
JOURNAL ARTICLE
Xuqing Li, Li Wang, Xinwang Ying, Yujun Zheng, Qianqian Tan, Xiaolan Yu, Jiahong Gong, Ming Li, Xiaofeng Deng, Guanhu Yang, Shengcun Li, Songhe Jiang
Electroacupuncture (EA) has both anti-inflammatory and cardio-protective effects. Activation of calpain pathway is involved in several myocardiopathy. In sepsis, the role of calpain-2-regulated STAT3 in cardio-protective mechanism of electroacupuncture remains unclear. In this study, we aimed to elucidate the mechanism by which electroacupuncture reduces cardiac inflammation and apoptosis and improves cardiac function during sepsis. Electroacupuncture pretreatment for 7 days was applied in septic cardiomyopathy model induced by lipopolysaccharide (LPS)...
2022: Frontiers in Physiology
https://read.qxmd.com/read/36134835/icd-indication-in-hypertrophic-cardiomyopathy-which-algorithm-to-use
#28
JOURNAL ARTICLE
Marcelo Antônio Oliveira Santos-Veloso, Ândrea Virgínia Ferreira Chaves, Eveline Barros Calado, Manuel Markman, Lucas Soares Bezerra, Sandro Gonçalves de Lima, Brivaldo Markman Filho, Dinaldo Cavalcanti de Oliveira
OBJECTIVE: This study aimed to evaluate the agreement in the indication of implantable cardioverter-defibrillators in patients with Hypertrophic cardiomyopathy, as per the 2014 European Society of Cardiology and 2020 American Heart Association recommendations, and evaluate fragmented QRS as a predictor of cardiovascular outcome. METHODS: Retrospective cohort with 81 patients was evaluated between 2019 and 2021. Patients with hypertrophic cardiomyopathy ≥16 years old were included...
August 2022: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/36066272/invasive-versus-non-invasive-coronary-microvascular-assessment-in-hypertrophic-myocardiopathy-are-we-measuring-the-same-thing
#29
JOURNAL ARTICLE
Nuno Bettencourt
No abstract text is available yet for this article.
September 2022: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://read.qxmd.com/read/35818131/mid-aortic-syndrome-a-rare-cause-of-heart-failure-in-infants
#30
Lu Zhao, Li Zhu, Qu-Ming Zhao, Lan He, Xue-Cun Liang, Lai-Shuan Wang, Lin Wu
This case reports describe a rare disease, mid-aortic syndrome (MAS), that can cause severe heart failure and hypertension in infancy. The typical images, key points of diagnosis, and therapy methods of the disease have also been presented. We report two critical thoracoabdominal aortic coarctation cases in infants aged 2 and 11 months with severe heart failure. The patients were initially misdiagnosed as dilated myocardiopathy, with the correct diagnosis confirmed through imaging. Both patients underwent balloon angioplasty; one patient also had bare-metal stents implanted...
July 11, 2022: ESC Heart Failure
https://read.qxmd.com/read/35780321/regular-combined-training-and-vitamins-modulated-the-apoptosis-process-in-diabetic-rats-bioinformatics-analysis-of-heart-failure-s-differential-genes-expression-network-correlated-with-anti-apoptotic-process
#31
JOURNAL ARTICLE
Elaheh Heydarnia, Farzaneh Taghian, Khosro Jalali Dehkordi, Mehrzad Moghadasi
The apoptosis process could impose significantly by hyperglycemia. According to in silico language processing and high throughput raw data analysis, we recognized hub molecular mechanisms involved in the pathogenesis of diabetic hearts and suggested a new pharmaceutical approach for declining myocardial programed cell death. Fifty male Sprague-Dawley rats were classified into five groups: healthy rats as control, diabetic rats, diabetic combined resistance/endurance training, diabetic rats which consumed supplementation vitamins E and C, and the combined supplementation and training...
October 2022: Journal of Food Biochemistry
https://read.qxmd.com/read/35663705/beri-beri-and-wernicke-encephalopathy-in-a-thirty-year-old-male
#32
Madalena Lobao, Maria Beatriz Sampaio, Miguel Sousa Leite, Felisbela Gomes, Joao M Silva
A 30-year-old Turkish male was found lethargic and surrounded by vomit. At the hospital, severe hypernatremic dehydration and acute kidney failure were evident. His conscious level improved with fluid resuscitation. A differential diagnosis of altered mental status was considered. A complete clinical triad of Wernicke encephalopathy (WE), supported by MRI findings, was compatible with thiamine deficiency. Previous bariatric surgery was later confirmed. Despite no clinical signs of heart failure, a high level of NT-proBNP (N-terminal prohormone brain natriuretic peptide) and a dilated, hypokinetic myocardiopathy detected on the echocardiogram led us to assume beri-beri heart disease...
May 2022: Curēus
https://read.qxmd.com/read/35633822/cardiac-manifestations-in-iranian-patients-with-beh%C3%A3-et-s-disease
#33
JOURNAL ARTICLE
Soraya Shadmanfar, Maryam Masoumi, Fereydoun Davatchi, Massoomeh Akhlaghi, Seyedeh Tahereh Faezi, Hoda Kavosi, Javad Balasi, Niloofar Deravi, Seyed Mohammad Hashem Montazeri, Mansoor Namazi
Background : Behcet's disease (BD) is a vasculitis with multisystem and multiorgan involvement. Cardiac involvement in BD is a rare complication with a poor outcome that manifests itself in different forms. In this study, we aimed to investigate cardiac involvement in BD. Methods : This is a retrospective study based on cardiac manifestations in BD according to the data of the Behçet's Disease Unit, the Rheumatology Research Center, Tehran University of Medical Sciences, from registered patients from 1975 until June 2017...
July 2021: Journal of Tehran Heart Center
https://read.qxmd.com/read/35627167/new-variant-in-placophilin-2-gene-causing-arrhythmogenic-myocardiopathy
#34
JOURNAL ARTICLE
Fiama Caimi-Martinez, Guido Antoniutti, Rocio Blanco, Bernardo García de la Villa, Nelson Alvarenga, Nancy Govea-Callizo, Laura Torres-Juan, Damián Heine-Suñer, Jordi Rosell-Andreo, David Crémer Luengos, Jorge Alvarez-Rubio, Tomás Ripoll-Vera
INTRODUCTION: Arrhythmogenic cardiomyopathy (ACM) is an inherited disease characterized by progressive fibroadipose replacement of cardiomyocytes. Its diagnosis is based on imaging, electrocardiographic, histological and genetic/familial criteria. The development of the disease is based mainly on desmosomal genes. Knowledge of the phenotypic expression of each of these genes will help in both diagnosis and prognosis. The objective of this study is to describe the genotype-phenotype association of an unknown PKP2 gene variant in a family diagnosed with ACM...
April 27, 2022: Genes
https://read.qxmd.com/read/35436809/-establishment-of-a-predictive-model-of-septic-myocardiopathy-based-on-left-ventricular-global-longitudinal-strain
#35
JOURNAL ARTICLE
P L Yang, J Yuan, Y Chen, J Q Yu, Q G Zheng, Qihong Chen
Objectives: To explore the risk factors associated with septic cardiomyopathy and establish a predictive model of the disease based on left ventricular global longitudinal strain (LV GLS). Methods: Data from sepsis patients without a history of cardiac dysfunction who were treated in the Critical Care Department of the Northern Jiangsu People's Hospital from September, 2019 to January, 2021 were included in the analysis. The LV GLS was measured by echocardiography within 72 hours and the patients were divided into a septic myocardiopathy group (LV GLS>-17%) and a normal cardiac function group (LV GLS≤-17%)...
April 19, 2022: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/35430482/spinacetin-alleviates-doxorubicin-induced-cardiotoxicity-by-initiating-protective-autophagy-through-sirt3-ampk-mtor-pathways
#36
JOURNAL ARTICLE
Dawei Liu, Lei Zhao
BACKGROUND: Doxorubicin-induced myocardiopathy is a massive obstacle in administering chemotherapeutic drugs in cancer patients. PURPOSES: In the present study, we aim to investigate the effects of spinacetin, a flavonoid glycoside, on doxorubicin-induced cardiotoxicity. STUDY DESIGN: The doxorubicin-induced cardiotoxicity mice model was established to evaluate the cardioprotective effects of SP. The H9C2 cell line was used to study SP's potential mechanisms of action...
July 2022: Phytomedicine
https://read.qxmd.com/read/35327541/selenium-tgf-beta-and-infectious-endemic-cardiopathy-lessons-from-benchwork-to-clinical-application-in-chagas-disease
#37
REVIEW
Tania C Araujo-Jorge, Maria Teresa Rivera, Jean Vanderpas, Luciana R Garzoni, Anna Cristina C Carvalho, Mariana C Waghabi, Marcelo T Holanda, Mauro F F Mediano, Alejandro M Hasslocher-Moreno, Maria da Gloria Bonecini-Almeida, Roberto M Saraiva, Roberto R Ferreira
For over 60 years, selenium (Se) has been known as an essential microelement to many biological functions, including cardiovascular homeostasis. This review presents a compilation of studies conducted in the past 20 years related to chronic Chagas disease cardiomyopathy (CCC), caused by Trypanosoma cruzi infection, a neglected disease that represents a global burden, especially in Latin America. Experimental and clinical data indicate that Se may be used as a complementary therapy to prevent heart failure and improve heart function...
February 23, 2022: Biomolecules
https://read.qxmd.com/read/35124349/usefulness-of-ventricular-sense-response-in-last-generation-cardiac-resynchronization-therapy-devices
#38
JOURNAL ARTICLE
María P Bonomini, Daniel F Ortega, Emilio Logarzo, Nicolás Mangani, Analía Paolucci
OBJECTIVES: High percentages of pacing were associated to maximal symptomatic and mortality benefit from cardiac resynchronization therapy (CRT). Loss of CRT pacing is linked to intrinsic ventricular activation preceding biventricular pacing (BiV), as it occurs in patients with atrial fibrillation (AF). Last generation CRT devices incorporate the ventricular sense response (VSR) mechanism to maintain biventricular pacing in patients with atrial arrhythmias. This work aimed to characterize electrical dyssynchrony differences among baseline, BiV and VSR pacing, and determine whether the VSR mode is as beneficial as the BiV mode in terms of electrical dyssynchrony...
March 2022: Journal of Electrocardiology
https://read.qxmd.com/read/34991424/smart-delivery-of-epirubicin-to-cancer-cells-using-aptamer-modified-ferritin-nanoparticles
#39
JOURNAL ARTICLE
Rezvan Yazdian-Robati, Payam Bayat, Sina Dehestani, Maryam Hashemi, Seyed Mohammad Taghdisi, Khalil Abnous
Epirubicin (Epi) is a chemotherapy agent which is commonly used in treatment of cancers. However, despite being efficient, the tendency to use this drug is declining mostly due to its myocardiopathy and drug-resistance of tumour cells. Such side effects could be prevented using targeted nanocarriers. This study aims to evaluate targeted delivery of Epi to colon cancer cells using ferritin nanoparticles (Ft NPs) and mucin 1 (MUC1) aptamer (Apt) and formation of Apt-Epi Ft NPs. In the current study, Apt-Epi Ft NPs were prepared...
June 2022: Journal of Drug Targeting
https://read.qxmd.com/read/34948281/characterization-of-a-novel-splicing-variant-in-acylglycerol-kinase-agk-associated-with-fatal-sengers-syndrome
#40
JOURNAL ARTICLE
Sofia Barbosa-Gouveia, Maria E Vázquez-Mosquera, Emiliano Gonzalez-Vioque, Álvaro Hermida-Ameijeiras, Laura L Valverde, Judith Armstrong-Moron, Maria Del Carmen Fons-Estupiña, Liesbeth T Wintjes, Antonia Kappen, Richard J Rodenburg, Maria L Couce
Mitochondrial functional integrity depends on protein and lipid homeostasis in the mitochondrial membranes and disturbances in their accumulation can cause disease. AGK , a mitochondrial acylglycerol kinase, is not only involved in lipid signaling but is also a component of the TIM22 complex in the inner mitochondrial membrane, which mediates the import of a subset of membrane proteins. AGK mutations can alter both phospholipid metabolism and mitochondrial protein biogenesis, contributing to the pathogenesis of Sengers syndrome...
December 15, 2021: International Journal of Molecular Sciences
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