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Myocardiopathy

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https://www.readbyqxmd.com/read/29129480/-takotsubo-myocardiopathy-when-coronary-arteries-are-silent
#1
Jonathan Cardona-Vélez, Laura Ceballos-Naranjo, Sneider Torres-Soto
No abstract text is available yet for this article.
November 9, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/29100908/quality-of-life-in-children-participating-in-a-non-selective-inr-self-monitoring-vka-education-programme
#2
Pascal Amedro, Fanny Bajolle, Helena Bertet, Radhia Cheurfi, Dominique Lasne, Erika Nogue, Pascal Auquier, Marie-Christine Picot, Damien Bonnet
BACKGROUND: The quality of life (QoL) of children receiving vitamin K antagonist (VKA) treatment has been scarcely studied. AIM: To assess QoL of children, and its evolution, throughout our non-selective international normalized ratio (INR) self-monitoring education programme. METHODS: Children and parents completed QoL questionnaires (Qualin, PedsQL) during education sessions. Scores were compared with those from controls. RESULTS: A total of 111 children (mean±standard deviation age 8...
October 31, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28965596/serum-quantitative-proteomic-analysis-of-patients-with-keshan-disease-based-on-itraq-labeling-technique-a-first-term-study
#3
YuXiao Sun, ChuanYu Gao, XianQing Wang, YiQiang Yuan, YuHao Liu, JunGe Jia
Keshan disease (KD), an endemic myocardiopathy, with unknown etiology, is still threatening human health. Proteomics studies of Keshan disease is rarely known. In the current study, isobaric tags for relative and absolute quantitation (iTRAQ) labeling coupled with two-dimensional liquid chromatography-tandem mass spectrometry (2D-LC-MS/MS) was firstly used to screen for the differentially expressed proteins (DEPs) in serum between Keshan disease and healthy residents in endemic area. 27 differentially expressed proteins were quantified, 9 of which were significantly altered (fold change > 1...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28781361/takotsubo-myocardiopathy-and-hyperthyroidism-a-case-report-and-literature-review
#4
Darío Rueda, Rafael Aguirre, Damián Contardo, Paola Finocchietto, Silvia Hernandez, Horacio di Fonzo
BACKGROUND Takotsubo cardiomyopathy (TM), also called stress myocardiopathy or transient left ventricular apical ballooning syndrome, is characterized by acute left ventricular dysfunction with reversible wall motion abnormalities. TM resembles acute coronary syndrome (ACS) in the absence of coronary artery disease (CAD). In several reports, TM has been described in association with hyperthyroidism, suggesting the potential role of thyrotoxicosis in the pathophysiology. CASE REPORT We present the case of a 34-year-old man with TM associated with hyperthyroidism caused by Graves' disease...
August 7, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28647361/apolipoprotein-o-expression-in-mouse-liver-enhances-hepatic-lipid-accumulation-by-impairing-mitochondrial-function
#5
Feng Tian, Chen-Lu Wu, Bi-Lian Yu, Ling Liu, Jia-Rui Hu
Apolipoprotein O (ApoO) was recently observed in the cellular mitochondrial inner membrane, which plays a role in mitochondrial function and is associated with myocardiopathy. Empirical information on the physiological functions of apoO is therefore limited. In this study, we aimed to elucidate the effect of apoO on hepatic fatty acid metabolism. An adenoviral vector expressing hApoO was constructed and introduced into chow diet and high-fat diet induced mice and the L02 human hepatoma cell line. High levels of hApoO mRNA and protein were detected in the liver, and the expression of lipid metabolism genes was significantly altered compared with negative controls...
September 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28565783/traditional-chinese-medicine-baoxin-decoction-improves-cardiac-fibrosis-of-rats-with-dilated-cardiomyopathy
#6
Rongrong Sun, Jiangbo Wang, Yi Zheng, Xianchi Li, Tiantian Xie, Rui Li, Min Liu, Yong Cao, Lei Lu, Qing Zhang, Peiying Zhang
We investigated the effect of baoxin decoction (BXD) on myocardial fibrosis and clarified the possible mechanism of action. Dilated myocardiopathy was induced by doxorubicin injected intraperitoneally for 6 weeks. Rats that demonstrated dilated myocardiopathy were randomly divided into five groups plus a control group. Three groups were treated with BXD (7.5/kg, 15 g/kg and 30 g/kg) daily for 4 weeks. One group was treated with 8.75 g/kg of captopril (positive control), and with physiologic saline (negative control)...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28392102/creatine-phosphate-administration-in-cell-energy-impairment-conditions-a-summary-of-past-and-present-research
#7
REVIEW
A V Gaddi, P Galuppo, J Yang
BACKGROUND: Creatine phosphate (CrP) plays a fundamental physiological role by providing chemical energy for cell viability and activity, especially in muscle tissue. Numerous pathological conditions, caused by acute or chronic ischaemic situations, are related to its deficiency. For these reasons, it has been used as a cardioprotective agent in heart surgery and medical cardiology for many years. OBJECTIVE: This article gives a brief overview of the main characteristics of exogenous CrP...
March 14, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27922195/the-neuropeptide-cortistatin-attenuates-experimental-autoimmune-myocarditis-via-inhibition-of-cardiomyogenic-t-cell-driven-inflammatory-responses
#8
Virginia Delgado-Maroto, Clara P Falo, Irene Forte-Lago, Norma Adan, Maria Morell, Elena Maganto-Garcia, Gema Robledo, Francisco O'Valle, Andrew H Lichtman, Elena Gonzalez-Rey, Mario Delgado
BACKGROUND AND PURPOSE: Myocarditis is an inflammatory and autoimmune cardiovascular disease that causes dilated myocardiopathy and is responsible for high morbidity and mortality worldwide. Cortistatin is a neuropeptide produced by neurons and cells of the immune and vascular systems. Besides its action in locomotor activity and sleep, cortistatin inhibits inflammation in different experimental models of autoimmune diseases. However, its role in inflammatory cardiovascular disorders is unexplored...
February 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27446307/clinical-effects-of-carvedilol-and-trimetazidine-for-the-treatmentof-alcoholic-myocardiopathy
#9
Hui Li, Fu-Yuan Liu, Xiao-Lan Li, Xiao-Mei Li, Lei Zhu
The aim of the study was to compare the clinical effects of carvedilol and trimetazidine for the treatment of alcoholic cardiomyopathy. A total of 60 patients diagnosed with alcoholic cardiomyopathy were enrolled in the study. The patients were randomly divided into the carvedilol (n=20), trimetazidine (n=20) and control (n=20) groups. The patients in the control, carvedilol and trimetazidine groups were treated with conventional drugs, conventional drugs + carvedil and conventional drugs + trimetazidine respectively, for 12 weeks...
August 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27324645/morphological-and-functional-abnormalities-pattern-in-hypertrophy-free-hcm-mutation-carriers-detected-with-echocardiography
#10
Jérôme Peyrou, Patricia Réant, Amélie Reynaud, Claire Cornolle, Marina Dijos, Caroline Rooryck-Thambo, Mathieu Landelle, Michel Montaudon, François Laurent, Raymond Roudaut, Stéphane Lafitte
To evaluate if morphological or functional abnormalities could be detected with echocardiography in hypertrophic myocardiopathy (HCM) mutation carriers without left ventricle (LV) hypertrophy has developed. HCM is caused by extensive genes mutations found in two-third of patients. Because screening for carriership of a large population is unreasonable, identification of asymptomatic subjects is confined to the use of imaging such as echocardiography, by which subtle abnormalities can be detected. Comprehensive echocardiographic studies including morphological and functional assessment were performed...
September 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27153464/role-of-ambulatory-blood-pressure-monitoring-in-patients-with-acromegaly
#11
Fabiola Costenaro, Adriana Martin, Roberta F Horn, Mauro A Czepielewski, Ticiana C Rodrigues
BACKGROUND: Hypertension is associated with increased cardiovascular deaths in patients with acromegaly. OBJECTIVE: To evaluate the accuracy of blood pressure (BP) by 24-h ambulatory blood pressure monitoring (ABPM) and office BP measurements to represent the real BP status in acromegalic patients and its relationship with acromegalic activity and echocardiogram parameters. PATIENTS AND METHODS: Cohort of 37 patients with acromegaly in a tertiary endocrine outpatient service...
July 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/26894450/topical-carbonic-anhydrase-inhibitors-in-macular-edema-associated-with-alstr%C3%A3-m-syndrome
#12
Paula Larrañaga-Fragoso, Natalia Pastora, Luciano Bravo-Ljubetic, Jesús Peralta, José Abelairas-Gómez
BACKGROUND: Alström syndrome is a rare genetic ciliopathy caused by a mutation in the ALMS1 gene. The syndrome is characterized by cone-rod dystrophy, dilated myocardiopathy, childhood obesity and sensorineural hearing loss. To date, cystoid macular edema has not been reported. METHODS: A female affected by Alström syndrome developed bilateral cystoid macular edema evidenced by optical coherence tomography. A topical carbonic anhydrase inhibitor was prescribed...
December 2016: Ophthalmic Genetics
https://www.readbyqxmd.com/read/26281203/-the-concurrence-of-light-chain-deposition-disease-al-amyloidosis-and-cast-nephropathy-in-a-patient-with-multiple-myeloma
#13
I G Rekhtina, E V Zakharova, E S Stolyarevich, M N Sinitsina, E N Denisova
Despite of the fact that their clinical manifestations are similar, AL-amyloidosis (AL-A) and light chain deposition disease (LCDD) are individual nosological entities in view of considerable differences in their pathogenesis and pathomorphology. The paper describes a rare case of the concurrence of LCDD and AL-A in a patient with multiple myeloma. Clinically, there was dialysis-dependent renal failure, flail leg syndrome, myocardiopathy, and rhabdomyolysis. At the disease onset, his nephrobiopsy specimen could diagnose LCDD and myeloma or cast nephropathy...
2015: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/26249047/-ecg-in-patients-with-tako-tsubo-cardiomyopathy
#14
Hendrik Bonnemeier
Takotsubo cardiomyopathy, also known as transient left ventricular ballooning and stress myocardiopathy, has been diagnosed increasingly more over the last decade. The takotsubo syndrome mimics acute myocardial infarction in symptoms and in electrocardiographic findings. There are two major types of takotsubo cardiomyopathy: the classical type with left ventricular apical ballooning and a type with midventricular ballooning. Both types show different electrocardiographic patterns at presentation. The present article describes classical electrocardiographic findings of the acute and subacute phases of takotsubo cardiomyopathy...
September 2015: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/26228800/what-s-new-in-heart-failure-in-the-patient-with-type-2-diabetes
#15
REVIEW
Miguel Camafort
Type 2 diabetes mellitus (T2DM) is considered an independent risk factor of heart failure (HF). It has been observed that diabetics have a higher risk of heart failure than non-diabetics. However, many aspects are still unknown; for example, the existence of a particular myocardiopathy common to T2DM, the pathogenesis of the HF associated with T2DM that is still not sufficiently clear, its role in the prognosis of HF, or the influence of anti-diabetic treatments on the outcome of the HF. An attempt is made in this review to summarise all those findings that have been published in the past 5 years as regards this interesting question, placing special emphasis on those questions still unresolved...
August 2015: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/26140150/excessive-weight-and-obesity-are-associated-to-intra-ventricular-asynchrony-pilot-study
#16
Nydia Ávila-Vanzzini, Cyntia Zulema Machain Leyva, Luis Eduardo Rodríguez Castellanos, José Antonio Arias Godínez, María Eugenia Ruiz Esparza, Hector Herrera Bello
BACKGROUND: Excessive weight and obesity (EwO) are independent factors in the development of heart failure; they lead to a state of myocardiopathy via inflammatory and hormonal mechanisms. If excessively accumulated, epicardial fat favors a proinflammatory state. Ventricular asynchrony is a marker of heart failure progression and has been poorly studied in EwO. The objective was evaluate the relation between epicardial fat, body mass index (BMI) and mechanical synchrony measured by echocardiography, in healthy individuals with EwO...
June 2015: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/26046421/analyses-of-inappropriate-shocks-in-a-spanish-icd-primary-prevention-population-predictors-and-prognoses
#17
MULTICENTER STUDY
Agustín Fernández-Cisnal, Álvaro Arce-León, Eduardo Arana-Rueda, Moisés Rodríguez-Mañero, Cristina González-Cambeiro, Jose Moreno-Arribas, Larraitz Gaztañaga, Rocío Castillo Poyo, Pilar Cabanas-Grandío, Miguel A Arias, Ana Andrés de la Huerta, Juan Miguel Sánchez Gómez, Luis Martínez-Sande, Alonso Pedrote
BACKGROUND: ICDs have been demonstrated to be highly effective in the primary prevention of sudden death, but inappropriate shocks (IS) occur frequently and represent one of the most important adverse effects of ICDs. The aim of this study was to analyze IS and identify the clinical predictors and prognostic implications of ISs in a real-world primary prevention ICD population. METHODS: This multicenter retrospective study was performed in 13 centers with experience in the field of ICD implantation (at least 30 per year) and ICD follow-up in Spain...
September 15, 2015: International Journal of Cardiology
https://www.readbyqxmd.com/read/26043149/cardiac-complications-during-pregnancy-are-better-predicted-with-the-modified-who-risk-score
#18
A Pijuan-Domènech, L Galian, M Goya, M Casellas, C Merced, I Ferreira-Gonzalez, J R Marsal-Mora, L Dos-Subirà, M T Subirana-Domènech, V Pedrosa, F Baró-Marine, S Manrique, J Casaldàliga-Ferrer, P Tornos, L Cabero, D Garcia-Dorado
BACKGROUND/OBJECTIVE: Several risk scores (RSs) have been used to stratify risk of cardiac complications (CCs) in pregnant patients with heart disease. We aimed to compare and contrast the accuracy of several RSs for predicting CC in this population. METHODS: Prospective inclusion of all consecutive pregnant patients with heart disease, and follow-up until 6 months postpartum. CCs were defined as primary if admission was required due to heart failure, arrhythmia or thromboembolic events, and secondary if the decline in NYHA class compared with baseline was >2 or urgent invasive cardiac procedures were needed...
September 15, 2015: International Journal of Cardiology
https://www.readbyqxmd.com/read/25851549/scorpion-related-cardiomyopathy-clinical-characteristics-pathophysiology-and-treatment
#19
REVIEW
Fekri Abroug, Elatrous Souheil, Islem Ouanes, Fahmi Dachraoui, Mohamed Fekih-Hassen, Lamia Ouanes Besbes
CONTEXT: Scorpion envenomation is a threat to more than 2 billion people worldwide with an annual sting number exceeding one million. Acute heart failure presenting as cardiogenic shock or pulmonary edema, or both is the most severe presentation of scorpion envenomation accounting for 0.27% lethality rate. OBJECTIVE: The purpose of this review is to characterize the scorpion-related cardiomyopathy, clarify its pathophysiological mechanisms, and describe potentially useful treatments in this particular context...
July 2015: Clinical Toxicology
https://www.readbyqxmd.com/read/25733492/trypanothione-reductase-inhibitors-overview-of-the-action-of-thioridazine-in-different-stages-of-chagas-disease
#20
REVIEW
M Silvina Lo Presti, P Carolina Bazán, Mariana Strauss, Alejandra L Báez, H Walter Rivarola, Patricia A Paglini-Oliva
Thioridazine (TDZ) is a phenothiazine that has been shown to be one of the most potent phenothiazines to inhibit trypanothione reductase irreversibly. Trypanothione reductase is an essential enzyme for the survival of Trypanosoma cruzi in the host. Here, we reviewed the use of this drug for the treatment of T. cruzi experimental infection. In our laboratory, we have studied the effect of TDZ for the treatment of mice infected with different strains of T. cruzi and treated in the acute or in the chronic phases of the experimental infection, using two different schedules: TDZ at a dose of 80 mg/kg/day, for 3 days starting 1h after infection (acute phase), or TDZ 80 mg/kg/day for 12 days starting 180 days post infection (d...
May 2015: Acta Tropica
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