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Hui Li, Fu-Yuan Liu, Xiao-Lan Li, Xiao-Mei Li, Lei Zhu
The aim of the study was to compare the clinical effects of carvedilol and trimetazidine for the treatment of alcoholic cardiomyopathy. A total of 60 patients diagnosed with alcoholic cardiomyopathy were enrolled in the study. The patients were randomly divided into the carvedilol (n=20), trimetazidine (n=20) and control (n=20) groups. The patients in the control, carvedilol and trimetazidine groups were treated with conventional drugs, conventional drugs + carvedil and conventional drugs + trimetazidine respectively, for 12 weeks...
August 2016: Experimental and Therapeutic Medicine
Jérôme Peyrou, Patricia Réant, Amélie Reynaud, Claire Cornolle, Marina Dijos, Caroline Rooryck-Thambo, Mathieu Landelle, Michel Montaudon, François Laurent, Raymond Roudaut, Stéphane Lafitte
To evaluate if morphological or functional abnormalities could be detected with echocardiography in hypertrophic myocardiopathy (HCM) mutation carriers without left ventricle (LV) hypertrophy has developed. HCM is caused by extensive genes mutations found in two-third of patients. Because screening for carriership of a large population is unreasonable, identification of asymptomatic subjects is confined to the use of imaging such as echocardiography, by which subtle abnormalities can be detected. Comprehensive echocardiographic studies including morphological and functional assessment were performed...
June 20, 2016: International Journal of Cardiovascular Imaging
Fabiola Costenaro, Adriana Martin, Roberta F Horn, Mauro A Czepielewski, Ticiana C Rodrigues
BACKGROUND: Hypertension is associated with increased cardiovascular deaths in patients with acromegaly. OBJECTIVE: To evaluate the accuracy of blood pressure (BP) by 24-h ambulatory blood pressure monitoring (ABPM) and office BP measurements to represent the real BP status in acromegalic patients and its relationship with acromegalic activity and echocardiogram parameters. PATIENTS AND METHODS: Cohort of 37 patients with acromegaly in a tertiary endocrine outpatient service...
July 2016: Journal of Hypertension
Paula Larrañaga-Fragoso, Natalia Pastora, Luciano Bravo-Ljubetic, Jesús Peralta, José Abelairas-Gómez
BACKGROUND: Alström syndrome is a rare genetic ciliopathy caused by a mutation in the ALMS1 gene. The syndrome is characterized by cone-rod dystrophy, dilated myocardiopathy, childhood obesity and sensorineural hearing loss. To date, cystoid macular edema has not been reported. METHODS: A female affected by Alström syndrome developed bilateral cystoid macular edema evidenced by optical coherence tomography. A topical carbonic anhydrase inhibitor was prescribed...
February 19, 2016: Ophthalmic Genetics
I G Rekhtina, E V Zakharova, E S Stoliarevich, M N Sinitsina, E N Denisova
Despite of the fact that their clinical manifestations are similar, AL-amyloidosis (AL-A) and light chain deposition disease (LCDD) are individual nosological entities in view of considerable differences in their pathogenesis and pathomorphology. The paper describes a rare case of the concurrence of LCDD and AL-A in a patient with multiple myeloma. Clinically, there was dialysis-dependent renal failure, flail leg syndrome, myocardiopathy, and rhabdomyolysis. At the disease onset, his nephrobiopsy specimen could diagnose LCDD and myeloma or cast nephropathy...
2015: Terapevticheskiĭ Arkhiv
Hendrik Bonnemeier
Takotsubo cardiomyopathy, also known as transient left ventricular ballooning and stress myocardiopathy, has been diagnosed increasingly more over the last decade. The takotsubo syndrome mimics acute myocardial infarction in symptoms and in electrocardiographic findings. There are two major types of takotsubo cardiomyopathy: the classical type with left ventricular apical ballooning and a type with midventricular ballooning. Both types show different electrocardiographic patterns at presentation. The present article describes classical electrocardiographic findings of the acute and subacute phases of takotsubo cardiomyopathy...
September 2015: Herzschrittmachertherapie & Elektrophysiologie
Miguel Camafort
Type 2 diabetes mellitus (T2DM) is considered an independent risk factor of heart failure (HF). It has been observed that diabetics have a higher risk of heart failure than non-diabetics. However, many aspects are still unknown; for example, the existence of a particular myocardiopathy common to T2DM, the pathogenesis of the HF associated with T2DM that is still not sufficiently clear, its role in the prognosis of HF, or the influence of anti-diabetic treatments on the outcome of the HF. An attempt is made in this review to summarise all those findings that have been published in the past 5 years as regards this interesting question, placing special emphasis on those questions still unresolved...
August 2015: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
Nydia Ávila-Vanzzini, Cyntia Zulema Machain Leyva, Luis Eduardo Rodríguez Castellanos, José Antonio Arias Godínez, María Eugenia Ruiz Esparza, Hector Herrera Bello
BACKGROUND: Excessive weight and obesity (EwO) are independent factors in the development of heart failure; they lead to a state of myocardiopathy via inflammatory and hormonal mechanisms. If excessively accumulated, epicardial fat favors a proinflammatory state. Ventricular asynchrony is a marker of heart failure progression and has been poorly studied in EwO. The objective was evaluate the relation between epicardial fat, body mass index (BMI) and mechanical synchrony measured by echocardiography, in healthy individuals with EwO...
June 2015: Journal of Cardiovascular Ultrasound
Agustín Fernández-Cisnal, Álvaro Arce-León, Eduardo Arana-Rueda, Moisés Rodríguez-Mañero, Cristina González-Cambeiro, Jose Moreno-Arribas, Larraitz Gaztañaga, Rocío Castillo Poyo, Pilar Cabanas-Grandío, Miguel A Arias, Ana Andrés de la Huerta, Juan Miguel Sánchez Gómez, Luis Martínez-Sande, Alonso Pedrote
BACKGROUND: ICDs have been demonstrated to be highly effective in the primary prevention of sudden death, but inappropriate shocks (IS) occur frequently and represent one of the most important adverse effects of ICDs. The aim of this study was to analyze IS and identify the clinical predictors and prognostic implications of ISs in a real-world primary prevention ICD population. METHODS: This multicenter retrospective study was performed in 13 centers with experience in the field of ICD implantation (at least 30 per year) and ICD follow-up in Spain...
September 15, 2015: International Journal of Cardiology
A Pijuan-Domènech, L Galian, M Goya, M Casellas, C Merced, I Ferreira-Gonzalez, J R Marsal-Mora, L Dos-Subirà, M T Subirana-Domènech, V Pedrosa, F Baró-Marine, S Manrique, J Casaldàliga-Ferrer, P Tornos, L Cabero, D Garcia-Dorado
BACKGROUND/OBJECTIVE: Several risk scores (RSs) have been used to stratify risk of cardiac complications (CCs) in pregnant patients with heart disease. We aimed to compare and contrast the accuracy of several RSs for predicting CC in this population. METHODS: Prospective inclusion of all consecutive pregnant patients with heart disease, and follow-up until 6 months postpartum. CCs were defined as primary if admission was required due to heart failure, arrhythmia or thromboembolic events, and secondary if the decline in NYHA class compared with baseline was >2 or urgent invasive cardiac procedures were needed...
September 15, 2015: International Journal of Cardiology
Fekri Abroug, Elatrous Souheil, Islem Ouanes, Fahmi Dachraoui, Mohamed Fekih-Hassen, Lamia Ouanes Besbes
CONTEXT: Scorpion envenomation is a threat to more than 2 billion people worldwide with an annual sting number exceeding one million. Acute heart failure presenting as cardiogenic shock or pulmonary edema, or both is the most severe presentation of scorpion envenomation accounting for 0.27% lethality rate. OBJECTIVE: The purpose of this review is to characterize the scorpion-related cardiomyopathy, clarify its pathophysiological mechanisms, and describe potentially useful treatments in this particular context...
July 2015: Clinical Toxicology
M Silvina Lo Presti, P Carolina Bazán, Mariana Strauss, Alejandra L Báez, H Walter Rivarola, Patricia A Paglini-Oliva
Thioridazine (TDZ) is a phenothiazine that has been shown to be one of the most potent phenothiazines to inhibit trypanothione reductase irreversibly. Trypanothione reductase is an essential enzyme for the survival of Trypanosoma cruzi in the host. Here, we reviewed the use of this drug for the treatment of T. cruzi experimental infection. In our laboratory, we have studied the effect of TDZ for the treatment of mice infected with different strains of T. cruzi and treated in the acute or in the chronic phases of the experimental infection, using two different schedules: TDZ at a dose of 80 mg/kg/day, for 3 days starting 1h after infection (acute phase), or TDZ 80 mg/kg/day for 12 days starting 180 days post infection (d...
May 2015: Acta Tropica
Tadashi Isomura
No abstract text is available yet for this article.
June 2014: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Isidro Vitoria, Elena Martín-Hernández, Luis Peña-Quintana, María Bueno, Pilar Quijada-Fraile, Jaime Dalmau, Sofia Molina-Marrero, Belén Pérez, Begoña Merinero
BACKGROUND: Carnitine-acylcarnitine translocase (CACT) deficiency is a rare autosomal recessive disease in the mitochondrial transport of long-chain fatty acids. Despite early diagnosis and treatment, the disease still has a high mortality rate. METHODS: Clinical symptoms, long-term follow-up, and biochemical and molecular results of four cases are described and compared with the reviewed literature data of 55 cases. RESULTS: Two cases with neonatal onset, carrying in homozygosity the novel variant sequences p...
2015: JIMD Reports
A Hofer, H Kratochwill, A Pentsch, M Gabriel
Positron emission tomography with [(18)F]-fluorodeoxyglucose provides functional and anatomic information by visualising the uptake of radiolabelled glucose in tumour and inflammatory cells. We report delayed diagnosis of necrosis of the gastric fundus after blunt abdominal trauma in a 73-year-old man. After a car accident with head-on collision, the patient was stabilised in our emergency room. His femur was treated by internal fixation, his ellbow was stabilised by a fixateur externe. During surgery his status deteriorated...
February 2015: Wiener Klinische Wochenschrift
Marcelo Villaça Lima, Marcelo E Ochiai, Kelly N Vieira, Airton Scipioni, Juliano N Cardoso, Robinson T Munhoz, Paulo C Morgado, Antonio C P Barretto
Adjunctive and non-pharmacological therapies, such as heat, for the treatment of heart failure patients have been proposed. Positive results have been obtained in clinically stable patients, but no studies of the use of thermal therapy in patients with decompensated heart failure (DHF) have been reported. An open randomized clinical trial was designed in patients with DHF and controls. We studied 38 patients with a mean age of 56.9 years. A total of 86.8% were men, and 71% had nonischemic myocardiopathy. All participants were using dobutamine, and the median brain natriuretic peptide (BNP) level was 1396 pg/mL...
2014: International Heart Journal
Maja Ercegovac, Dragan Subotic, Vladimir Zugic, Radoslav Jakovic, Dejan Moskovljevic, Slavisa Bascarevic, Natasa Mujovic
BACKGROUND: The pattern and factors influencing the lung function recovery in the first postoperative days are still not fully elucidated, especially in patients at increased risk. METHODS: Prospective study on 60 patients at increased risk, who underwent a lung resection for primary lung cancer. INCLUSION CRITERIA: complete resection and one or more known risk factors in form of COPD, cardiovascular disorders, advanced age or other comorbidities...
2014: Journal of Cardiothoracic Surgery
YouZhang Xiang, Qun Xu, WuHong Tan, ShuLan He, XiaoWei Shi, WenMing Zhang, Jing Wang, XiuHong Wang, WeiJuan Ma
The etiology of Keshan disease (KD), an endemic myocardiopathy in regions of China, is largely unknown. To show the protein changes in serum from KD patients versus controls and idiopathic dilated cardiomyopathy (IDCM) and to search specific biological markers for differential diagnosis for KD. Serum of 65 patients with KD was compared with 29 patients with IDCM, 62 controls from KD areas and 28 controls from non-KD areas by ClinProt/MALDI-ToF technique. The genetic algorithm, quick classifier algorithm and supervised neural network algorithm methods were used to screen marker proteins and establish diagnostic model...
August 2014: Protein Journal
Geng-Qian Zhang, Zheng Liang, Xiao-Jia Zhang
Sphingosine-1-phosphate (S1P) has been demonstrated to be a mediator and marker of heart diseases. We hypothesized that the expression of S1P receptors is involved in the S1P-mediated cardioprotection in vivo and may serve as a biomarker of ischemic heart disease. In vivo models of myocardial ischemia (MI) and ischemia-reperfusion (IR) were established by ligation of the left anterior descending artery (LAD) of rat heart, the mRNA expressions of S1PR1-3 were detected using real time PCR at different time intervals after ischemia (LAD for 15 min, 30 min, and 1 h) and IR...
April 25, 2014: Sheng Li Xue Bao: [Acta Physiologica Sinica]
M Cordeiro, F Scaglia, S Lopes Da Silva, P Garcia, M Grazina, C Moura, L Diogol
Mitochondrial respiratory chain disorders (MRCD) are a heterogeneous group of diseases leading to an inadequate production of ATP. Brain and heart are among the most affected organs. Thus far, no specific relationship has been found between specific affected areas in the central nervous system and cardiac involvement. This study investigated the relationship between specific brain involvement and heart disease in mitochondrial disorders. We hypothesize that specific areas of brain lesions in children with MRCD are more frequently correlated to heart disease than others...
December 14, 2009: Neuroradiology Journal
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