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https://www.readbyqxmd.com/read/27650288/reporting-and-dealing-with-missing-quality-of-life-data-in-rcts-has-the-picture-changed-in-the-last-decade
#1
REVIEW
S Fielding, A Ogbuagu, S Sivasubramaniam, G MacLennan, C R Ramsay
PURPOSE: Missing data are a major problem in the analysis of data from randomised trials affecting power and potentially producing biased treatment effects. Specifically focussing on quality of life outcomes, we aimed to report the amount of missing data, whether imputation was used and what methods and was the missing mechanism discussed from four leading medical journals and compare the picture to our previous review nearly a decade ago. METHODS: A random selection (50 %) of all RCTS published during 2013-2014 in BMJ, JAMA, Lancet and NEJM was obtained...
December 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27637413/reporting-on-data-monitoring-committees-in-neonatal-randomised-controlled-trials-is-inconsistent
#2
L M Perrem, S Gosling, I Ravikumar, A S Khashan, J Miletin, C A Ryan, E Dempsey
AIM: To evaluate the reported use of Data Monitoring Committees (DMCs), the frequency of interim analysis, pre-specified stopping rules and early trial termination in neonatal randomised controlled trials (RCTs). METHODS: We reviewed neonatal RCTs published in four high impact general medical journals, specifically looking at safety issues including documented involvement of a DMC, stated interim analysis, stopping rules and early trial termination. We searched all journal issues over an 11-year period (2003-2013) and recorded predefined parameters on each item for RCTs meeting inclusion criteria...
September 16, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/26650174/ischemic-optic-neuropathies
#3
(no author information available yet)
No abstract text is available yet for this article.
December 10, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26378905/arthroscopic-partial-meniscectomy-for-meniscal-tears-a-review-and-commentary-on-a-study-by-nejm
#4
Anthony J Scillia, James D McDermott, Kimona Issa, Peter Goljan, Steven F Harwin, Anthony Festa, Vincent K McInerney
Arthroscopic partial meniscectomy (APM) has been demonstrated to be effective when performed in the appropriately indicated patient. However, a recent study published in the New England Journal of Medicine (NEJM) questioned whether or not the procedure actually had any clinical benefit whatsoever. Despite being a prospective, Level 1, randomized study, there are several aspects of the study that must be taken into consideration when interpreting the findings, including but not limited to the patient selection criteria, limited sample size, and lack of information regarding meniscal tear patterns...
July 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/24779345/immunocompetent-murine-models-for-the-study-of-glioblastoma-immunotherapy
#5
REVIEW
Taemin Oh, Shayan Fakurnejad, Eli T Sayegh, Aaron J Clark, Michael E Ivan, Matthew Z Sun, Michael Safaee, Orin Bloch, Charles D James, Andrew T Parsa
Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in clinical outcomes are modest, in no small part due to tumor-induced immunosuppressive mechanisms that promote immune escape and immuno-resistance. Immunotherapeutic strategies aimed at bolstering the immune response while neutralizing immunosuppression will play a critical role in improving treatment outcomes for glioblastoma patients...
2014: Journal of Translational Medicine
https://www.readbyqxmd.com/read/24256399/severe-sepsis-and-septic-shock
#6
(no author information available yet)
Severe Sepsis and Septic Shock Review Article, N Engl J Med 2013;369:840-851. In Table 2 (page 846), the grade given for "Continue fluid-challenge technique as long as there is hemodynamic improvement" (row 6 under Resuscitation) should have been UG, rather than 1C. The article is correct at NEJM.org.
November 21, 2013: New England Journal of Medicine
https://www.readbyqxmd.com/read/23089378/-brown-white-beige-the-color-of-fat-and-new-therapeutic-perspectives-for-obesity
#7
REVIEW
E Kuhn, N Binart, M Lombès
Three articles published in the NEJM in 2009 have renewed the interest for brown adipose tissue (BAT) in humans. This review reports interesting new findings on adipocyte cell types that have been presented at the last meeting of the Endocrine Society in Houston, TX, in June 2012. Many studies have focused on identifying factors involved in brown adipocyte lineage, the site of adaptive thermogenesis. Indeed, the role of the transcription factors, such as PRDM16, in brown adipocyte differentiation has been unambiguously established...
October 2012: Annales D'endocrinologie
https://www.readbyqxmd.com/read/22039194/magnitude-of-effects-in-clinical-trials-published-in-high-impact-general-medical-journals
#8
Konstantinos C M Siontis, Evangelos Evangelou, John P A Ioannidis
BACKGROUND: Prestigious journals select for publication studies that are considered most important and informative. We aimed to examine whether high-impact general (HIG) medical journals systematically demonstrate more favourable results for experimental interventions compared with the rest of the literature. METHODS: We scrutinized systematic reviews of the Cochrane Database (Issue 4, 2009) and meta-analyses published in four general journals (2008-09). Eligible articles included ≥1 binary outcome meta-analysis(es) pertaining to effectiveness with ≥1 clinical trial(s) published in NEJM, JAMA or Lancet...
October 2011: International Journal of Epidemiology
https://www.readbyqxmd.com/read/21913531/treatment-of-uncomplicated-malaria-in-africa-evaluation-of-randomized-clinical-trials
#9
REVIEW
P O Erah, P A Aghayere, I A Suleman, T P Osahon
BACKGROUND: Malaria is a major devastating infectious diseases in tropical countries. The resistance of P. falciparum to the traditional antimalarial drugs is believed to be contributing to increased malaria mortality. OBJECTIVE: The purpose of this study is to evaluate randomized clinical trials of uncomplicated P. faciparum malaria with the hope of providing recent scientific evidence on the current antimalarial drugs that would be effective, safe, affordable and available in Africa...
October 2010: Nigerian Quarterly Journal of Hospital Medicine
https://www.readbyqxmd.com/read/21737403/risk-factors-and-interventions-with-statistically-significant-tiny-effects
#10
George C M Siontis, John P A Ioannidis
BACKGROUND: Large studies may identify postulated risk factors and interventions with very small effect sizes. We aimed to assess empirically a large number of statistically significant relative risks (RRs) of tiny magnitude and their interpretation by investigators. METHODS: RRs in the range between 0.95 and 1.05 were identified in abstracts of articles of cohort studies; articles published in NEJM, JAMA or Lancet; and Cochrane reviews. For each eligible tiny effect and the respective study, we recorded information on study design, participants, risk factor/intervention, outcome, effect estimates, P-values and interpretation by study investigators...
October 2011: International Journal of Epidemiology
https://www.readbyqxmd.com/read/19914573/review-of-an-article-the-international-warfarin-pharmacogenetics-consortium-2009-estimation-of-the-warfarin-dose-with-clinical-and-pharmacogenetic-data-nejm-360-8-753-64
#11
Janice D Nunnelee
No abstract text is available yet for this article.
December 2009: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/19545379/dealing-with-heterogeneity-of-treatment-effects-is-the-literature-up-to-the-challenge
#12
Nicole B Gabler, Naihua Duan, Diana Liao, Joann G Elmore, Theodore G Ganiats, Richard L Kravitz
BACKGROUND: Some patients will experience more or less benefit from treatment than the averages reported from clinical trials; such variation in therapeutic outcome is termed heterogeneity of treatment effects (HTE). Identifying HTE is necessary to individualize treatment. The degree to which heterogeneity is sought and analyzed correctly in the general medical literature is unknown. We undertook this literature sample to track the use of HTE analyses over time, examine the appropriateness of the statistical methods used, and explore the predictors of such analyses...
June 19, 2009: Trials
https://www.readbyqxmd.com/read/19259751/update-in-women-s-health
#13
REVIEW
Pamela S Ganschow, Elizabeth A Jacobs, Jennifer Mackinnon, Pamela Charney
INTRODUCTION: The aim of this clinical update is to summarize articles and guidelines published in the last year with the potential to change current clinical practice as it relates to women's health. METHODS: We used two independent search strategies to identify articles relevant to women's health published between March 1, 2007 and February 29, 2008. First, we reviewed the Cochrane Database of Systematic Reviews and journal indices from the ACP Journal Club, Annals of Internal Medicine, Archives of Internal Medicine, British Medical Journal, Circulation, Diabetes, JAMA, JGIM, Journal of Women's Health, Lancet, NEJM, Obstetrics and Gynecology, and Women's Health Journal Watch...
June 2009: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/17458396/a-descriptive-analysis-of-authorship-within-medical-journals-1995-2005
#14
Marc E Levsky, Alex Rosin, Troy P Coon, William L Enslow, Michael A Miller
INTRODUCTION: The emphasis on publications for promotion in academic medicine would lead one to the theory that authorship numbers would increase proportionally with this emphasis. To investigate authorship trends across a number of periodicals, we performed a descriptive study comparing two full years of published articles spaced ten years apart from five medical journals. METHODS: Physician reviewers each reviewed all articles of one medical journal for the 1995 and 2005 publication years...
April 2007: Southern Medical Journal
https://www.readbyqxmd.com/read/16855268/the-gender-gap-in-authorship-of-academic-medical-literature-a-35-year-perspective
#15
Reshma Jagsi, Elizabeth A Guancial, Cynthia Cooper Worobey, Lori E Henault, Yuchiao Chang, Rebecca Starr, Nancy J Tarbell, Elaine M Hylek
BACKGROUND: Participation of women in the medical profession has increased during the past four decades, but issues of concern persist regarding disparities between the sexes in academic medicine. Advancement is largely driven by peer-reviewed original research, so we sought to determine the representation of female physician-investigators among the authors of selected publications during the past 35 years. METHODS: Original articles from six prominent medical journals--the New England Journal of Medicine (NEJM), the Journal of the American Medical Association (JAMA), the Annals of Internal Medicine (Ann Intern Med), the Annals of Surgery (Ann Surg), Obstetrics & Gynecology (Obstet Gynecol), and the Journal of Pediatrics (J Pediatr)--were categorized according to the sex of both the first and the senior (last listed) author...
July 20, 2006: New England Journal of Medicine
https://www.readbyqxmd.com/read/16542448/the-developing-world-in-the-new-england-journal-of-medicine
#16
Bernard Lown, Amitava Banerjee
BACKGROUND: Rampant disease in poor countries impedes development and contributes to growing North-South disparities; however, leading international medical journals underreport on health research priorities for developing countries. METHODS: We examined 416 weekly issues of the New England Journal of Medicine (NEJM) over an eight-year period, January 1997 to December 2004. A total of 8857 articles were reviewed by both authors. The content of each issue was evaluated in six categories: research, review articles, editorial, correspondence, book reviews and miscellaneous...
2006: Globalization and Health
https://www.readbyqxmd.com/read/12038921/extrapolation-of-correlation-between-2-variables-in-4-general-medical-journals
#17
Yen-Hong Kuo
CONTEXT: An estimated correlation between 2 variables is valid only within the range of observed data. Extrapolation is risky and should be performed with caution. METHODS: To assess the prevalence of problems with data extrapolation in the medical literature, all articles published from January through June 2000 in BMJ, JAMA, The Lancet, and The New England Journal of Medicine (NEJM) were reviewed manually. Articles containing at least 1 scatterplot with raw data and a corresponding fitted regression line were included in the analysis...
June 5, 2002: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/11730216/influence-of-preoperative-computed-tomography-on-patients-undergoing-appendectomy
#18
G P McDonald, D P Pendarvis, R Wilmoth, B J Daley
The frequency of computed tomography (CT) ordered by emergency department physicians at our facility was noted to sharply increase in early 1998 after a New England Journal of Medicine (NEJM) article recommending routine CT in patients with suspected appendicitis. Numerous studies have proven the accuracy of CT for detecting acute appendicitis; however, the most appropriate use of CT continues to evolve. We sought to evaluate the effect of increased CT use on negative appendectomy rate and perforation rate at our institution and to better delineate in whom CT is most beneficial...
November 2001: American Surgeon
https://www.readbyqxmd.com/read/7900404/women-participants-in-research-assessing-progress
#19
REVIEW
K G Low, M R Joliceour, R A Colman, L E Stone, C L Fleisher
This study reviewed 1,050 articles published in the New England Journal of Medicine, the American Journal of Psychiatry, and the Journal of Consulting and Clinical Psychology in 1982 and 1991/92. The NEJM included the fewest female subjects at both assessments (26.6% in 1982 and 36.5% in 1991/92), and one way analysis of variance showed a significantly smaller percentage of women in the NEJM compared to either the AJP or the JCCP (F = (2,1048) = 11.5, p < .001) in 1991/92. The NEJM did increase the percentage of women participants over the decade (t(534) = 3...
1994: Women & Health
https://www.readbyqxmd.com/read/7699481/changes-in-study-design-gender-issues-and-other-characteristics-of-clinical-research-published-in-three-major-medical-journals-from-1971-to-1991
#20
M M McDermott, F Lefevre, J Feinglass, D Reifler, N Dolan, S Potts, K Senger
OBJECTIVE: To examine trends in study design and other characteristics of original research published in JAMA, Lancet, and the New England Journal of Medicine (NEJM) between 1971 and 1991. DESIGN: A retrospective cross-sectional study of original clinical research published in JAMA, Lancet, and NEJM during 1971, 1981, and 1991. MEASUREMENTS: Four hundred forty-four articles were independently reviewed by at least two investigators and classified according to study design and other preselected study characteristics...
January 1995: Journal of General Internal Medicine
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