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Lactate MRI

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https://www.readbyqxmd.com/read/29662077/pharmacodynamics-of-mutant-idh1-inhibitors-in-glioma-patients-probed-by-in-vivo-3d-mrs-imaging-of-2-hydroxyglutarate
#1
Ovidiu C Andronesi, Isabel C Arrillaga-Romany, K Ina Ly, Wolfgang Bogner, Eva M Ratai, Kara Reitz, A John Iafrate, Jorg Dietrich, Elizabeth R Gerstner, Andrew S Chi, Bruce R Rosen, Patrick Y Wen, Daniel P Cahill, Tracy T Batchelor
Inhibitors of the mutant isocitrate dehydrogenase 1 (IDH1) entered recently in clinical trials for glioma treatment. Mutant IDH1 produces high levels of 2-hydroxyglurate (2HG), thought to initiate oncogenesis through epigenetic modifications of gene expression. In this study, we show the initial evidence of the pharmacodynamics of a new mutant IDH1 inhibitor in glioma patients, using non-invasive 3D MR spectroscopic imaging of 2HG. Our results from a Phase 1 clinical trial indicate a rapid decrease of 2HG levels by 70% (CI 13%, P = 0...
April 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29575569/clinical-biochemical-and-genetic-features-of-four-patients-with-short-chain-enoyl-coa-hydratase-echs1-deficiency
#2
Patricia E Fitzsimons, Charlotte L Alston, Penelope E Bonnen, Joanne Hughes, Ellen Crushell, Michael T Geraghty, Martine Tetreault, Peter O'Reilly, Eilish Twomey, Yusra Sheikh, Richard Walsh, Hans R Waterham, Sacha Ferdinandusse, Ronald J A Wanders, Robert W Taylor, James J Pitt, Philip D Mayne
Short-chain enoyl-CoA hydratase (SCEH or ECHS1) deficiency is a rare inborn error of metabolism caused by biallelic mutations in the gene ECHS1 (OMIM 602292). Clinical presentation includes infantile-onset severe developmental delay, regression, seizures, elevated lactate, and brain MRI abnormalities consistent with Leigh syndrome (LS). Characteristic abnormal biochemical findings are secondary to dysfunction of valine metabolism. We describe four patients from two consanguineous families (one Pakistani and one Irish Traveler), who presented in infancy with LS...
March 25, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29572891/novel-link-between-gut-microbiome-derived-metabolite-and-shared-gene-effects-with-hepatic-steatosis-and-fibrosis-in-nafld
#3
Cyrielle Caussy, Cynthia Hsu, Min-Tzu Lo, Amy Liu, Ricki Bettencourt, Veeral H Ajmera, Shirin Bassirian, Jonathan Hooker, Ethan Sy, Lisa Richards, Nicholas Schork, Bernd Schnabl, David A Brenner, Claude B Sirlin, Chi-Hua Chen, Rohit Loomba
Previous studies have shown that gut-microbiome is associated with nonalcoholic fatty liver disease (NAFLD). We aimed to examine if serum metabolites especially those derived from the gut-microbiome have a shared gene-effect with hepatic steatosis and fibrosis. This is a cross-sectional analysis of a prospective discovery cohort including 156 well-characterized Twins and Families with untargeted metabolome profiling assessment. Hepatic steatosis was assessed using magnetic-resonance-imaging proton-density-fat-fraction (MRI-PDFF) and fibrosis using MR-elastography (MRE)...
March 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29567434/using-a-local-low-rank-plus-sparse-reconstruction-to-accelerate-dynamic-hyperpolarized-13-c-imaging-using-the-bssfp-sequence
#4
Eugene Milshteyn, Cornelius von Morze, Galen D Reed, Hong Shang, Peter J Shin, Peder E Z Larson, Daniel B Vigneron
Acceleration of dynamic 2D (T2 Mapping) and 3D hyperpolarized13 C MRI acquisitions using the balanced steady-state free precession sequence was achieved with a specialized reconstruction method, based on the combination of low rank plus sparse and local low rank reconstructions. Methods were validated using both retrospectively and prospectively undersampled in vivo data from normal rats and tumor-bearing mice. Four-fold acceleration of 1-2 mm isotropic 3D dynamic acquisitions with 2-5 s temporal resolution and two-fold acceleration of 0...
March 11, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29559544/vitamin-d-is-crucial-for-maternal-care-and-offspring-social-behaviour-in-rats
#5
Nathanael J Yates, Dijana Tesic, Kirk W Feindel, Jeremy T Smith, Michael W Clarke, Celeste Wale, Rachael C Crew, Michaela D Wharfe, Andrew J O Whitehouse, Caitlin S Wyrwoll
Early life vitamin D plays a prominent role in neurodevelopment and subsequent brain function, including schizophrenic-like outcomes and increasing evidence for an association with autism spectrum disorder (ASD). Here, we investigate how early life vitamin D deficiency during rat pregnancy and lactation alters maternal care and influences neurodevelopment and affective, cognitive and social behaviours in male adult offspring. Sprague-Dawley rats were placed on either a vitamin D control (2195 IU/kg) or deficient diet (0 IU/kg) for five weeks before timed mating, and diet exposure was maintained until weaning of offspring on postnatal day (PND) 23...
May 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29556351/perfluorocarbon-enhanced-glasgow-oxygen-level-dependent-gold-magnetic-resonance-metabolic-imaging-identifies-the-penumbra-following-acute-ischemic-stroke
#6
Graeme A Deuchar, David Brennan, William M Holmes, Martin Shaw, I Mhairi Macrae, Celestine Santosh
The ability to identify metabolically active and potentially salvageable ischaemic penumbra is crucial for improving treatment decisions in acute stroke patients. Our solution involves two complementary novel MRI techniques (Glasgow Oxygen Level Dependant (GOLD) Metabolic Imaging), which when combined with a perfluorocarbon (PFC) based oxygen carrier and hyperoxia can identify penumbra due to dynamic changes related to continued metabolism within this tissue compartment. Our aims were (i) to investigate whether PFC offers similar enhancement of the second technique (Lactate Change) as previously demonstrated for the T2 *OC technique (ii) to demonstrate both GOLD metabolic imaging techniques working concurrently to identify penumbra, following administration of Oxycyte® (O-PFC) with hyperoxia...
2018: Theranostics
https://www.readbyqxmd.com/read/29552435/plasmacytoma-of-the-skull-base-a-rare-tumor
#7
Abhilasha Siyag, Tej P Soni, Anil K Gupta, Lalit M Sharma, Naresh Jakhotia, Shantanu Sharma
Plasmacytoma of the skull-base is a rare entity. Differential diagnosis includes chordoma, osteosarcoma, carcinoma nasopharynx, meningioma, metastatic carcinoma, lymphoma, and multiple myeloma. Accurate and precise diagnosis is extremely important for plasmacytoma of the skull-base as its treatment and prognosis is different from other skull-base lesions. A 41-year-old man presented with concerns of headache, diplopia, and left eye strabismus. A magnetic resonance image (MRI) of his brain showed a large expansile mass measuring 51 mm involving the clivus and central skull-base...
January 15, 2018: Curēus
https://www.readbyqxmd.com/read/29523278/predictors-of-oedema-type-in-reversible-posterior-leukoencephalopathy-syndrome-with-preeclampsia-or-eclampsia
#8
Xiao-Bo Fang, Dun-Jin Chen, Fang He, Jia Chen, Zhou Zhou, Yan-Ling Liang, Wei-Xi Zhang
OBJECTIVE: To explore the predictive factors of oedema types in reversible posterior leukoencephalopathy syndrome (RPLS) with preeclampsia (PE) and eclampsia, which is closely related to reversible lesions and clinical recovery. METHOD: We collected data from 44 consecutive patients diagnosed with RPLS in PE or eclampsia between 2013 and 2017. All patients were classified into vasogenic oedema (n = 31) or cytotoxic oedema (n = 13) groups according to magnetic resonance imaging (MRI) results...
January 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29520870/effects-of-anesthesia-on-renal-function-and-metabolism-in-rats-assessed-by-hyperpolarized-mri
#9
Haiyun Qi, Christian Østergaard Mariager, Jakob Lindhardt, Per Mose Nielsen, Hans Stødkilde-Jørgensen, Christoffer Laustsen
PURPOSE: Anesthesia is necessary for most animal studies requiring invasive procedures. It is well documented that various types of anesthesia modulate a wide variety of important metabolic and functional processes in the body, and as such, represent a potential limitation in the study design. In the present study, we aimed to investigate the renal functional and metabolic consequences of 3 typical rodent anesthetics used in preclinical MRI: sevoflurane, inaction, and a mixture of fentanyl, fluanisone, and midazolam (FFM)...
March 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29509618/maternal-diets-deficient-in-vitamin-d-increase-the-risk-of-kyphosis-in-offspring-a-novel-kyphotic-porcine-model
#10
Matthew A Halanski, Blake Hildahl, Laura A Amundson, Ellen Leiferman, Annette Gendron-Fitzpatrick, Rajeev Chaudhary, Heather M Hartwig-Stokes, Ronald McCabe, Rachel Lenhart, Matthew Chin, Jennifer Birstler, Thomas D Crenshaw
BACKGROUND: The purpose of this study was to explore the role of perinatal vitamin-D intake on the development and characterization of hyperkyphosis in a porcine model. METHODS: The spines of 16 pigs were assessed at 9, 13, and 17 weeks of age with radiography and at 17 weeks with computed tomography (CT), magnetic resonance imaging (MRI), histology, and bone-density testing. An additional 169 pigs exposed to 1 of 3 maternal dietary vitamin-D levels from conception through the entire lactation period were fed 1 of 4 nursery diets supplying different levels of vitamin D, calcium, and phosphorus...
March 7, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29506576/effects-of-isoflurane-sevoflurane-propofol-and-alfaxalone-on-brain-metabolism-in-dogs-assessed-by-proton-magnetic-resonance-spectroscopy-1-h-mrs
#11
Franz Josef Söbbeler, Inés Carrera, Kirby Pasloske, Millagahamada Gedara Ranasinghe, Patrick Kircher, Sabine Beate Rita Kästner
BACKGROUND: The purpose of this study was to determine the effects of isoflurane, sevoflurane, propofol and alfaxalone on the canine brain metabolite bioprofile, measured with single voxel short echo time proton magnetic resonance spectroscopy at 3 Tesla. Ten adult healthy Beagle dogs were assigned to receive isoflurane, sevoflurane, propofol and alfaxalone at 3 different dose rates each in a randomized cross-over study design. Doses for isoflurane, sevoflurane, propofol and alfaxalone were FE 'Iso 1...
March 5, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29501406/an-infant-case-of-diffuse-cerebrospinal-lesions-and-cardiomyopathy-caused-by-a-bola3-mutation
#12
Makoto Nishioka, Yuji Inaba, Mitsuo Motobayashi, Yosuke Hara, Ryusuke Numata, Yoshiro Amano, Kunihiko Shingu, Yoichiro Yamamoto, Kei Murayama, Akira Ohtake, Yozo Nakazawa
INTRODUCTION: Mitochondrial dysfunction results in a wide range of organ disorders through diverse genetic abnormalities. We herein present the detailed clinical course of an infant admitted for extensive, rapidly progressing white matter lesions and hypertrophic cardiomyopathy due to a BOLA3 gene mutation. CASE: A 6-month-old girl with no remarkable family or past medical history until 1 month prior presented with developmental regression and feeding impairment...
February 28, 2018: Brain & Development
https://www.readbyqxmd.com/read/29488244/in-vivo-hyperpolarization-transfer-in-a-clinical-mri-scanner
#13
Cornelius von Morze, Galen D Reed, Peder E Larson, Daniele Mammoli, Albert P Chen, James Tropp, Mark Van Criekinge, Michael A Ohliger, John Kurhanewicz, Daniel B Vigneron, Matthew E Merritt
PURPOSE: The purpose of this study was to investigate the feasibility of in vivo13 C->1 H hyperpolarization transfer, which has significant potential advantages for detecting the distribution and metabolism of hyperpolarized13 C probes in a clinical MRI scanner. METHODS: A standalone pulsed13 C RF transmit channel was developed for operation in conjunction with the standard1 H channel of a clinical 3T MRI scanner. Pulse sequences for13 C power calibration and polarization transfer were programmed on the external hardware and integrated with a customized water-suppressed1 H MRS acquisition running in parallel on the scanner...
February 27, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29464462/gestational-and-lactational-exposure-to-dichlorinated-bisphenol-a-induces-early-alterations-of-hepatic-lipid-composition-in-mice
#14
Dounia El Hamrani, Amandine Chepied, William Même, Marc Mesnil, Norah Defamie, Sandra Même
OBJECTIVE: Using non-invasive magnetic resonance (MR) techniques and a histological approach, we assessed the outcomes of perinatal exposure at a low dose of 3,3'-DCBPA (2-chloro-4-[1-(3-chloro-4-hydroxyphenyl)-1-methylethyl]phenol) and/or 3,5-DCBPA (2,6-dichloro-4-[1-(4-hydroxyphenyl)-1-methylethyl]phenol) on mice livers. MATERIALS AND METHODS: Fertilized female Swiss mice were injected intraperitoneally during gestation and lactation with either vehicle control, 20 μg/kg/day of BPA, 3,5-DCBPA, 3,3'-DCBPA or a mixture (mix-DCBPA)...
February 20, 2018: Magma
https://www.readbyqxmd.com/read/29460911/-masks-of-acute-neuroinfections-and-markers-of-differencial-diagnosis
#15
A S Shishov, I S Petrova, P V Boytsov, V G Leva, V E Malikov, S A Rusanova, A V Surovikina, I A Blank
AIM: To compare thе medical history, clinical features, composition of cerebrospinal fluid (CSF), results of laboratory and instrumental examinations of patients with acute neuroinfections and differentiable diseases including a pseudoinflammatory variant of the acute stage of uncomplicated subarachnoid hemorrhage (SAH), consequences of traumatic brain injury (traumatic SAH, SAN combination with secondary purulent meningitis, posttraumatic nasal liquorrhea, intracerebral hematomas), abscesses and tumors of the brain, lymphoma with proven CNS...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29451329/high-spatiotemporal-resolution-bssfp-imaging-of-hyperpolarized-1-13-c-pyruvate-and-1-13-c-lactate-with-spectral-suppression-of-alanine-and-pyruvate-hydrate
#16
Eugene Milshteyn, Cornelius von Morze, Jeremy W Gordon, Zihan Zhu, Peder E Z Larson, Daniel B Vigneron
PURPOSE: The balanced steady-state free precession (bSSFP) acquisition enables high spatiotemporal resolution for hyperpolarized 13 C MRI at 3T but is limited by spectral contamination from adjacent resonances. The purpose of this study was to develop a framework for in vivo dynamic high resolution imaging of hyperpolarized [1- 13 C]pyruvate and [1- 13 C]lactate generated in vivo at 3T by simplifying the spectrum through the use of selective suppression pulses. METHODS: Spectral suppression pulses were incorporated into the bSSFP sequence for suppression of [1- 13 C]alanine and [1- 13 C]pyruvate-hydrate signals, leaving only the pyruvate and lactate resonances...
February 16, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29444856/placental-physiology-monitored-by-hyperpolarized-dynamic-13-c-magnetic-resonance
#17
Stefan Markovic, Anne Fages, Tangi Roussel, Ron Hadas, Alexander Brandis, Michal Neeman, Lucio Frydman
Placental functions, including transport and metabolism, play essential roles in pregnancy. This study assesses such processes in vivo , from a hyperpolarized MRI perspective. Hyperpolarized urea, bicarbonate, and pyruvate were administered to near-term pregnant rats, and all metabolites displayed distinctive behaviors. Little evidence of placental barrier crossing was observed for bicarbonate, at least within the timescales allowed by13 C relaxation. By contrast, urea was observed to cross the placental barrier, with signatures visible from certain fetal organs including the liver...
March 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29436842/histogram-analysis-derived-from-apparent-diffusion-coefficient-adc-is-more-sensitive-to-reflect-serological-parameters-in-myositis-than-conventional-adc-analysis
#18
Hans Jonas Meyer, Alexander Emmer, Malte Kornhuber, Alexey Surov
OBJECTIVE: Diffusion-weighted imaging (DWI) has the potential of being able to reflect histopathology architecture. A novel imaging approach, namely histogram analysis, is used to further characterize tissues on MRI. The aim of this study was to correlate histogram parameters derived from apparent diffusion coefficient (ADC) maps with serological parameters in myositis. METHODS: 16 patients with autoimmune myositis were included in this retrospective study. DWI was obtained on a 1...
February 20, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29431100/sheehan-s-syndrome-presenting-as-cardiac-tamponade
#19
Ankit Mittal, Animesh Ray, Ram Manohar Talupula, Rita Sood
A 50-year-old woman presented with progressive dyspnoea and oedema with rapid deterioration over the last few days. Clinical examination revealed hypotension with cold clammy skin, raised jugular venous pressure and muffled heart sounds and was diagnosed to have cardiac tamponade, later confirmed on two-dimensional echocardiography. However, patient had bradycardia, and the other striking examination findings were coarse facies with pallor, madarosis, absent axillary and pubic hair and breast atrophy. Her blood sugar level was also low...
February 3, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29423350/primary-psychiatric-disorder-masking-the-diagnosis-of-neuropsychiatric-lupus-in-a-patient-with-altered-mental-status-a-case-report
#20
Osman Perez, Kairavee Dave, Aimee Almanzar, Tajul Prodhan, Livasky Concepion
Neuropsychiatric systemic lupus erythematosus (NPSLE) has a wide variety of neurologic and psychiatric features. NPSLE symptoms and the psychotic features of primary psychiatric disorders often overlap with each other. These psychotic features often mask and delay the diagnosis of NPSLE. We present the case of a 59-year-old female previously diagnosed with bipolar disorder and generalized anxiety disorder presenting with altered mental status (AMS), subsequently diagnosed with neuropsychiatric lupus. Initially, medication overdose was suspected as an empty bottle of trazodone was found beside her...
October 23, 2017: Curēus
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