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Shock sepsis and liver

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https://www.readbyqxmd.com/read/28076507/effects-of-cococonut-water-and-simvastatin-in-the-treatment-of-sepsis-and-hemorrhagic-shock-in-rats
#1
Vanessa de Fátima Lima Paiva Medeiros, Ítalo Medeiros Azevedo, Marília Daniela Ferreira Carvalho, Eryvaldo Sócrates Tabosa Egito, Aldo Cunha Medeiros
PURPOSE: To evaluate the effects of modified coconut water as fluid of resuscitation combined with simvastatin in hemorrhagic shock and sepsis model in rats. METHODS: Four groups of Wistar rats with hemorrhagic shock and abdominal sepsis were studied (n=8/group). Rats were bled and maintained at a mean blood pressure 35mmHg for 60min. They were then resuscitated with: 1) saline 0.9%; 2) coconut water+3% NaCl; 3) coconut water+NaCl 3%+simvastatin microemulsion (10 mg/kg i...
December 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28056039/prediction-models-and-their-external-validation-studies-for-mortality-of-patients-with-acute-kidney-injury-a-systematic-review
#2
Tetsu Ohnuma, Shigehiko Uchino
OBJECTIVES: To systematically review AKI outcome prediction models and their external validation studies, to describe the discrepancy of reported accuracy between the results of internal and external validations, and to identify variables frequently included in the prediction models. METHODS: We searched the MEDLINE and Web of Science electronic databases (until January 2016). Studies were eligible if they derived a model to predict mortality of AKI patients or externally validated at least one of the prediction models, and presented area under the receiver-operator characteristic curves (AUROC) to assess model discrimination...
2017: PloS One
https://www.readbyqxmd.com/read/28013574/predictive-value-of-serum-albumin-level-for-the-prognosis-of-severe-sepsis-without-exogenous-human-albumin-administration
#3
Mei Yin, Lei Si, Weidong Qin, Chen Li, Jianning Zhang, Hongna Yang, Hui Han, Fan Zhang, Shifang Ding, Min Zhou, Dawei Wu, Xiaomei Chen, Hao Wang
BACKGROUND: The prognostic significance of serum albumin levels in patients with sepsis has previously been reported; however, these studies have not excluded the potential confounding effect of exogenous albumin administration. In this study, we investigate the predictive value of serum albumin for the prognosis of severe sepsis without the interference of exogenous albumin administration. METHODS: A prospective cohort study was conducted from April to November 2014 in the internal and surgical intensive care units of a tertiary care hospital...
January 1, 2016: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28005910/melioidosis-in-malaysia-a-review-of-case-reports
#4
Paul Vijay Kingsley, Mark Leader, Nandika Suranjith Nagodawithana, Meghan Tipre, Nalini Sathiakumar
BACKGROUND: Melioidosis is a tropical infectious disease associated with significant mortality due to early onset of sepsis. OBJECTIVE: We sought to review case reports of melioidosis from Malaysia. METHODS: We conducted a computerized search of literature resources including PubMed, OVID, Scopus, MEDLINE and the COCHRANE database to identify published case reports from 1975 to 2015. We abstracted information on clinical characteristics, exposure history, comorbid conditions, management and outcome...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27942509/clinical-significance-of-cell-population-data-cpd-on-sysmex-xn-9000-in-septic-patients-with-our-without-liver-impairment
#5
Sabrina Buoro, Michela Seghezzi, Mauro Vavassori, Paola Dominoni, Sara Apassiti Esposito, Barbara Manenti, Tommaso Mecca, Gianmariano Marchesi, Enrico Castellucci, Giovanna Azzarà, Cosimo Ottomano, Giuseppe Lippi
BACKGROUND: This study evaluated the clinical significance of cell population data (CPD) parameters obtained on Sysmex XN-9000 in septic patients admitted to intensive care unit (ICU) and stratified according to liver function. METHODS: The study population consisted in 84 patients, 44 of whom did not develop sepsis (NS), whereas the remaining 40 developed sepsis (SE) (n=24) or septic shock (SS) (n=16). Two hundred ostensibly healthy blood donors [healthy subjects (HS)], undergoing routine blood testing before a regular blood donation, were studied...
November 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27924081/liver-guardian-modifier-and-target-of-sepsis
#6
REVIEW
Pavel Strnad, Frank Tacke, Alexander Koch, Christian Trautwein
Sepsis and septic shock are characterized by life-threatening organ dysfunction caused by a dysregulated host response to infection. The liver has a central role during sepsis, and is essential to the regulation of immune defence during systemic infections by mechanisms such as bacterial clearance, acute-phase protein or cytokine production and metabolic adaptation to inflammation. However, the liver is also a target for sepsis-related injury, including hypoxic hepatitis due to ischaemia and shock, cholestasis due to altered bile metabolism, hepatocellular injury due to drug toxicity or overwhelming inflammation, as well as distinct pathologies such as secondary sclerosing cholangitis in critically ill patients...
January 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27918369/preadministration-of-hydrogen-rich-water-protects-against-lipopolysaccharide-induced-sepsis-and-attenuates-liver-injury
#7
Masumi Iketani, Jumi Ohshiro, Takuya Urushibara, Mayumi Takahashi, Tomio Arai, Hideo Kawaguchi, Ikuroh Ohsawa
Despite significant advances in antibiotic therapy and intensive care, sepsis remains the most common cause of death in intensive care units. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant. Here, we show that preadministration of H2-dissolved water (HW) suppresses lipopolysaccharide (LPS)-induced endotoxin shock in mice. Drinking HW for 3 days before LPS injection prolonged survival in a mouse model of sepsis. The H2 concentration immediately increased in the liver but not in the kidney after drinking HW...
December 1, 2016: Shock
https://www.readbyqxmd.com/read/27862040/central-extracorporeal-life-support-with-left-ventricular-decompression-to-berlin-heart-excor-a-reliable-bridge-to-bridge-strategy-in-crash-and-burn-patients
#8
Alexander Weymann, Mina Farag, Anton Sabashnikov, Javid Fatullayev, Mohamed Zeriouh, Bastian Schmack, Rawa Arif, Florian Müller, Christina Alt, Philip Raake, Nikhil Prakash Patil, Aron-Frederik Popov, Andre Rüdiger Simon, Matthias Karck, Arjang Ruhparwar
The aim of this study was to compare patients with severe biventricular heart failure who underwent Berlin Heart Excor implantation with (cardiogenic shock [CS] status) or without the need for preoperative extracorporeal life support (ECLS) as a bridge to long-term device. A total of 40 consecutive patients with severe biventricular heart failure underwent Berlin Heart Excor implantation with (CS status, n = 20, 50%) or without (control, n = 20, 50%) the need for preoperative ECLS as a bridge to long-term device from March 2007 to May 2015 at our institution...
November 8, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27819302/protective-effect-of-cl-amidine-against-clp-induced-lethal-septic-shock-in-mice
#9
Ting Zhao, Baihong Pan, Hasan B Alam, Baoling Liu, Roderick T Bronson, Qiufang Deng, Erxi Wu, Yongqing Li
Production of innate and adaptive immune cells from hematopoietic stem cells, and maturation of T lymphocytes are effective immune responses to fight severe microbial infection. In sepsis, this emergency myelopoiesis is damaged, leading to failure of bacterial clearance, and excessive stress-induced steroids cause immature T-lymphocyte apoptosis in thymus. We recently found that Cl-amidine, a peptidylarginine deiminase (PAD) inhibitor, improves survival in a mouse model of cecal ligation and puncture (CLP)-induced septic shock...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27765437/pyogenic-liver-abscess-a-retrospective-study-of-105-cases-in-an-emergency-department-from-east-china
#10
Li Liu, Wanjun Chen, Xiaoye Lu, Keji Zhang, Changqing Zhu
BACKGROUND: Pyogenic liver abscesses have become common in emergency departments (EDs) in recent years in Shanghai, China due to a variety of risk factors contributory to the disease. OBJECTIVE: To review our experience in managing pyogenic liver abscesses to aid in the current management of this complex condition. METHODS: This retrospective study was conducted to collect and analyze information from adult patients diagnosed with liver hepatic abscesses who were admitted to Ren Ji Hospital during the period from January 1, 2010 to December 31, 2015...
October 17, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27758716/fructose-1-6-bisphosphate-a-summary-of-its-cytoprotective-mechanism
#11
Norma Alva, Ronald Alva, Teresa Carbonell
In clinical and experimental settings, a great deal of effort is being made to protect cells and tissues against harmful conditions and to facilitate metabolic recovery following these insults. Much of the recent attention has focused on the protective role of a natural form of sugar, fructose 1,6-bisphosphate (F16bP). F16bP is a high-energy glycolytic intermediate that has been shown to exert a protective action in different cell types and tissues (including the brain, kidney, intestine, liver and heart) against various harmful conditions...
October 14, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27752598/the-effect-of-liver-disease-on-lactate-normalization-in-severe-sepsis-and-septic-shock-a-cohort-study
#12
Sarah A Sterling, Michael A Puskarich, Alan E Jones
OBJECTIVE: To describe the effect of liver disease (LD) on lactate clearance during early sepsis resuscitation. METHODS: This is a multicenter randomized clinical trial. An initial lactate >2 mmol/L and subsequent serum lactate measurement within 6 hours were required for inclusion. LD was categorized by two methods: 1) past medical history (PMH) categorized as no LD, mild LD (no Child's score criteria, but PMH of hepatitis B/C), cirrhosis; and 2) measurable liver dysfunction determined by the liver component of the sequential organ failure assessment (L-SOFA) score as no dysfunction (L-SOFA score 0), mild dysfunction (score 1), moderate-severe dysfunction (score 2 to 4)...
December 2015: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/27708581/activation-of-endothelial-pro-resolving-anti-inflammatory-pathways-by-circulating-microvesicles-from-non-muscular-myosin-light-chain-kinase-deficient-mice
#13
Abderahim Gaceb, Luisa Vergori, M C Martinez, Ramaroson Andriantsitohaina
Microvesicles, small membrane vesicles released from cells, have beneficial and/or deleterious effects in sepsis. We previously reported that non-muscle myosin light chain kinase (nmMLCK) deletion protects mice against endotoxic shock by reducing inflammation. Here, we have evaluated the consequences of nmMLCK deletion on microvesicle phenotypes and their effects on mouse aortic endothelial cells in association with vascular inflammation and endothelial dysfunction during endotoxic shock induced by lipopolysaccharide in mice...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27611977/rural-patients-with-severe-sepsis-or-septic-shock-who-bypass-rural-hospitals-have-increased-mortality-an-instrumental-variables-approach
#14
Nicholas M Mohr, Karisa K Harland, Dan M Shane, Azeemuddin Ahmed, Brian M Fuller, Marcia M Ward, James C Torner
OBJECTIVE: To identify factors associated with rural sepsis patients' bypassing rural emergency departments to seek emergency care in larger hospitals, and to measure the association between rural hospital bypass and sepsis survival. DESIGN: Observational cohort study. SETTING: Emergency departments of a rural Midwestern state. PATIENTS: All adults treated with severe sepsis or septic shock between 2005 and 2014, using administrative claims data...
January 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/27610253/plesiomonas-shigelloides-septic-shock-leading-to-death-of-postsplenectomy-patient-with-pyruvate-kinase-deficiency-and-hemochromatosis
#15
Mohammed Samannodi, Andrew Zhao, Yaser Nemshah, Kevin Shiley
Although Plesiomonas shigelloides, a water-borne bacterium of the Enterobacteriaceae family, usually causes self-limiting gastroenteritis with diarrhea, several cases of sepsis have been reported. We report the case of a 43-year-old male patient with hemochromatosis, pyruvate kinase deficiency, and asplenia via splenectomy who developed septic shock caused by P. shigelloides complicated by respiratory failure, renal failure, liver failure, and disseminated intravascular coagulation. Early aggressive antimicrobial therapy and resuscitation measures were unsuccessful and the patient passed away...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27598288/-toxocarosis-and-acalculous-acute-cholecystitis-consequence-or-coincidence
#16
REVIEW
Alexis Strickler, Natalia Vásquez, Leonardo Maggi, Juvenal Hernández, Ximena Hidalgo
Human toxocarosis is a chronic larval parasitosis listed as one of the five most important neglected diseases by the CDC. The larvae can spread systemically and migrate to different tissues including liver and gallbladder. Acalculous acute cholecystitis (AAC) is a rare disease in children. The diagnosis is based on clinical parameters and imaging criteria. It has been reported in relation to sepsis, shock, trauma, burns, severe systemic diseases, congenital anomalies, infections and also in healthy children...
June 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27434564/-sepsis-associated-encephalopathy-is-an-independently-risk-factor-for-nosocomial-coma-in-patients-with-supratentorial-intracerebral-hemorrhage-a-retrospective-cohort-study-of-261-patients
#17
Guangsheng Wang, Shaodan Wang, Yeting Zhou, Xiaodong Chen, Xiaobo Ma, Daoming Tong
OBJECTIVE: To investigate whether the presence of sepsis associated encephalopathy (SAE) would predict nosocomial coma (NC) and poor outcome in patients with supratentorial intracerebral hemorrhage (SICH). METHODS: A retrospective cohort study was conducted. The adult acute SICH patients with or without coma admitted to intensive care unit (ICU) of Shuyang People' Hospital Affiliated to Xuzhou Medical University from December 2012 to December 2015 were enrolled...
August 2016: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/27427274/hesperidin-prevents-lipopolysaccharide-induced-endotoxicity-in-rats
#18
Solomon Oladapo Rotimi, Goodness Esther Bankole, Isaacson Bababode Adelani, Oluwakemi Anuoluwapo Rotimi
CONTEXT: Lipopolysaccharide (LPS) is a major trigger of septic shock resulting in multiple organ damage through excessive stimulation of the host's immune cells resulting in the release of cytokines. Previous studies have shown that hesperidin has several beneficial properties against inflammation and oxidative stress. OBJECTIVE: The influence of hesperidin on endotoxemia, endothelial dysfunction, inflammation, and oxidative stress was investigated using a murine model of sepsis...
October 2016: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#19
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27247902/expression-of-scavenger-receptor-a-in-rat-s-liver-tissue-during-acute-obstructive-cholangitis-and-its-significance
#20
Akanand Singh, Kang Yang, Zuojin Liu, Jianping Gong
OBJECTIVE: Acute obstructive cholangitis (AOC) is a severe disease that leads to sepsis, shock and multiple organ dysfunction syndrome. Liver is the largest and the major organ for the defense mechanisms during the sepsis. Our aim was to investigate the expression of scavenger receptor A (SRA) in rat's liver tissue during AOC and its relation with the inflammatory mediators and hepatic injury caused by endotoxins. METHODS: Ninety Wistar rats were randomly divided into three equal groups...
2016: SpringerPlus
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