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https://www.readbyqxmd.com/read/28092244/-depression-and-burden-on-primary-caregivers-of-elderly-persons-with-physical-dependence-of-the-umf-171
#1
Cristina Navarro-Sandoval, Lizbeth Carlota Uriostegui-Espíritu, Edna Gabriela Delgado-Quiñones, Minerva Natalia Sahagún-Cuevas
BACKGROUND: According to the National Health and Nutrition Survey of 2012, more than a quarter of older adults (26.9%) have some degree of disability, requiring a primary caregiver to perform basic activities of daily living. The aim is to determine the prevalence of depression and burden on primary caregivers of elderly persons with physical dependence. METHODS: A descriptive cross-sectional study with non-probability sampling that included the primary caregivers of elderly patients with physical dependence...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28073097/moringa-oleifera-a-species-with-potential-analgesic-and-anti-inflammatory-activities
#2
Claudia Lizbeth Martínez-González, Laura Martínez, Efraín J Martínez-Ortiz, María Eva González-Trujano, Myrna Déciga-Campos, Rosa Ventura-Martínez, Irene Díaz-Reval
Moringa oleifera has long been used in large demand in folk medicine to treat pain. The present study was undertaken to examine the antinociceptive and anti-inflammatory spectrum of M. oleifera leaf extracts discriminating the constituents' nature by using different kind of experimental models in rats. Pharmacological evaluation of a non-polar and/or polar extracts at several doses (30-300mg/kg, p.o.) was explored through experimental nociception using formalin test, carrageenan-induced paw edema and arthritis with subcutaneous injection of collagen in rats...
January 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28032670/prospective-study-of-definitive-chemoradiation-in-locally-or-regionally-advanced-squamous-cell-carcinoma-of-the-skin
#3
Michelle K Nottage, Charles Lin, Brett G M Hughes, Lizbeth Kenny, David D Smith, Kathleen Houston, Alessandra Francesconi
BACKGROUND: The purpose of this study was to present our evaluation of the outcomes of concurrent chemoradiotherapy (CRT) in patients with locally advanced cutaneous squamous cell carcinoma (SCC). METHODS: This was a prospective phase II study. The primary endpoint was complete response (CR). Patients with locally/regionally advanced cutaneous SCC deemed unsuitable for surgery received definitive radiotherapy (RT; 70 Gy in 35fractions) and concurrent weekly platinum-based chemotherapy (cisplatin 40 mg/m2 or carboplatin area under the curve 2)...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28024718/patterns-of-dysphagia-and-acute-toxicities-in-patients-with-head-and-neck-cancer-undergoing-helical-imrt%C3%A2-concurrent-chemotherapy
#4
Laura B Moroney, Jennifer Helios, Elizabeth C Ward, Jane Crombie, Leesa F Wockner, Clare L Burns, Ann-Louise Spurgin, Claire Blake, Lizbeth Kenny, Brett G M Hughes
BACKGROUND: There is limited prospective data reporting the extent of treatment related toxicities associated with helical Intensity Modulated Radiotherapy (H-IMRT) for head and neck cancer (HNC). The study aim was to investigate severity, peak incidence and recovery patterns of dysphagia and related toxicities in patients undergoing H-IMRT±chemotherapy to examine when patients are experiencing symptoms requiring supportive clinical care. METHODS: Prospective study of 212 patients undergoing H-IMRT...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28018365/cassava-breeding-ii-phenotypic-correlations-through-the-different-stages-of-selection
#5
Orlando Joaqui Barandica, Juan C Pérez, Jorge I Lenis, Fernando Calle, Nelson Morante, Lizbeth Pino, Clair H Hershey, Hernán Ceballos
Breeding cassava relies on a phenotypic recurrent selection that takes advantage of the vegetative propagation of this crop. Successive stages of selection (single row trial-SRT; preliminary yield trial-PYT; advanced yield trial-AYT; and uniform yield trials UYT), gradually reduce the number of genotypes as the plot size, number of replications and locations increase. An important feature of this scheme is that, because of the clonal, reproduction of cassava, the same identical genotypes are evaluated throughout these four successive stages of selection...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27998541/-incidence-of-hip-and-knee-prosthetic-infections-in-a-specialized-center-of-mexico-city
#6
Rafael Franco-Cendejas, Erika Lizbeth Contreras-Córdova, Jaime Arturo Mondragón-Eguiluz, Edgar Samuel Vanegas-Rodríguez, Víctor Manuel Ilizaliturri-Sánchez, Arturo Galindo-Fraga
BACKGROUND: Hip and knee prosthetic replacements have proven to be the most appropriate treatment in the joints that do not benefit from medical or arthroscopic interventions; however, infections are the most feared complication. It is recommended that the incidence of infection should not exceed 2%. MATERIAL AND METHODS: This was an observational, prospective, longitudinal and observational study conducted in patients fitted with a prosthetic joint from August 2011 to July 2012...
December 17, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27994742/development-of-1h-pyrazolo-3-4-b-pyridines-as-metabotropic-glutamate-receptor-5-positive-allosteric-modulators
#7
Matthew D Hill, Haiquan Fang, Jeffrey M Brown, Thaddeus Molski, Amy Easton, Xiaojun Han, Regina Miller, Melissa Hill-Drzewi, Lizbeth Gallagher, Michele Matchett, Michael Gulianello, Anand Balakrishnan, Robert L Bertekap, Kenneth S Santone, Valerie J Whiterock, Xiaoliang Zhuo, Joanne J Bronson, John E Macor, Andrew P Degnan
The metabotropic glutamate receptor 5 (mGluR5) is an attractive target for the treatment of schizophrenia due to its role in regulating glutamatergic signaling in association with the N-methyl-d-aspartate receptor (NMDAR). We describe the synthesis of 1H-pyrazolo[3,4-b]pyridines and their utility as mGluR5 positive allosteric modulators (PAMs) without inherent agonist activity. A facile and convergent synthetic route provided access to a structurally diverse set of analogues that contain neither the aryl-acetylene-aryl nor aryl-methyleneoxy-aryl elements, the predominant structural motifs described in the literature...
December 8, 2016: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27993517/development-of-spiroguanidine-derived-%C3%AE-7-neuronal-nicotinic-receptor-partial-agonists
#8
Matthew D Hill, Haiquan Fang, Sivarao V Digavalli, Francine L Healy, Lizbeth Gallagher, Debra Post-Munson, Ping Chen, Joanne Natale, Yulia Benitex, Daniel Morgan, Nicholas Lodge, Linda Bristow, John E Macor, Richard E Olson
We describe the synthesis of quinuclidine-containing spiroguanidines and their utility as α7 neuronal nicotinic acetylcholine receptor (nAChR) partial agonists. The convergent synthetic route developed for this study allowed for rapid SAR investigation and provided access to a structurally diverse set of analogs. A potent and selective α7 nAChR partial agonist, N-(6-methyl-1,3-benzoxazol-2-yl)-3',5'-dihydro-4-azaspiro[bicyclo[2.2.2]octane-2,4'-imidazole]-2'-amine (BMS-910731, 16), was identified. This compound induced immediate early genes c-fos and Arc in a preclinical rodent model of α7 nAChR-derived cellular activation and plasticity...
December 7, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27986517/comparison-of-nutritional-and-clinical-outcomes-in-patients-with-head-and-neck-cancer-undergoing-chemoradiotherapy-utilizing-prophylactic-versus-reactive-nutrition-support-approaches
#9
Teresa E Brown, Merrilyn D Banks, Brett G M Hughes, Charles Y Lin, Lizbeth M Kenny, Judith D Bauer
BACKGROUND: The optimal method of tube feeding for patients with head and neck cancer remains unclear. A validated protocol is available that identifies high-nutritional-risk patients who would benefit from prophylactic gastrostomy tube placement. Adherence to this protocol is ultimately determined by clinical team discretion or patient decision. OBJECTIVE: The study aim was to compare outcomes after adherence and nonadherence to this validated protocol, thus comparing a prophylactic and reactive approach to nutrition support in this patient population...
December 13, 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27958732/design-and-synthesis-of-a-new-series-of-4-heteroarylamino-1-azaspiro-oxazole-5-3-bicyclo-2-2-2-octanes-as-%C3%AE-7-nicotinic-receptor-agonists-1-development-of-pharmacophore-and-early-structure-activity-relationship
#10
James Cook, F Christopher Zusi, Ivar M McDonald, Dalton King, Matthew D Hill, Christiana Iwuagwu, Robert A Mate, Haiquan Fang, Rulin Zhao, Bei Wang, Jingfang Cutrone, Baoqing Ma, Qi Gao, Ronald J Knox, Michele Matchett, Lizbeth Gallagher, Meredith Ferrante, Debra Post-Munson, Thaddeus Molski, Amy Easton, Regina Miller, Kelli Jones, Siva Digavalli, Francine Healy, Kimberley Lentz, Yulia Benitex, Wendy Clarke, Joanne Natale, Judith A Siuciak, Nicholas Lodge, Robert Zaczek, Rex Denton, Daniel Morgan, Linda J Bristow, John E Macor, Richard E Olson
The design and synthesis of a series of quinuclidine-containing spirooxazolidines ("spiroimidates") and their utility as α7 nicotinic acetylcholine receptor partial agonists are described. Selected members of the series demonstrated excellent selectivity for α7 over the highly homologous 5-HT3A receptor. Modification of the N-spiroimidate heterocycle substituent led to (1S,2R,4S)-N-isoquinolin-3-yl)-4'H-4-azaspiro[bicyclo[2.2.2]octane-2,5'oxazol]-2'-amine (BMS-902483), a potent α7 partial agonist, which improved cognition in preclinical rodent models...
December 22, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27927252/dietary-inflammatory-index-and-prostate-cancer-risk-in-a-case-control-study-in-mexico
#11
Ruth A Vázquez-Salas, Nitin Shivappa, Marcia Galván-Portillo, Lizbeth López-Carrillo, James R Hébert, Luisa Torres-Sánchez
Recent evidence suggests that a pro-inflammatory diet could be associated with prostate cancer (PC) risk. To evaluate the association between dietary inflammatory index (DII) and PC risk as well as aggressiveness, we conducted a case-control study in Mexico City. Cases were 394 individuals with incident, histologically confirmed PC, who were matched by age (±5 years) with 794 population controls. Dietary information was obtained through a semi-quantitative FFQ with a 3-year frame of reference before diagnosis, for cases, or interview, for controls...
December 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27860379/behavior-associated-neuronal-activation-after-kainic-acid-induced-hippocampal-neurotoxicity-is-modulated-in-time
#12
Andrea Aguilar-Arredondo, Fernanda López-Hernández, Lizbeth García-Velázquez, Clorinda Arias, Angélica Zepeda
Kainic acid-induced (KA) hippocampal damage leads to neuronal death and further synaptic plasticity. Formation of aberrant as well as of functional connections after such procedure has been documented. However, the impact of such structural plasticity on cell activation along time after damage and in face of a behavioral demand has not been explored. We evaluated if the mRNA and protein levels of plasticity-related protein synaptophysin (Syp and SYP, respectively) and activity-regulated cytoskeleton-associated protein mRNA and protein levels (Arc and Arc, respectively) in the dentate gyrus were differentially modulated in time in response to a spatial-exploratory task after KA-induced hippocampal damage...
November 11, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27856994/nurse-educators-occupational-and-leisure-sitting-time
#13
Lizbeth P Sturgeon, Dawn Garrett-Wright, Eve Main, Donna Blackburn, M Susan Jones
Prolonged sitting time (ST) is a risk factor for all-cause mortality, independent of physical activity. Nurse educators are particularly at risk due to limited physical activity, older age, and the increasing use of computers. This descriptive correlational study was designed to explore the ST of nurse educators in relation to their self-reported health status and general health indicators. A convenience sample of 56 nurse educators was recruited, and participants completed demographic items, general health questions, and the Workforce Sitting Questionnaire (WSQ; Chau, van der Ploeg, Dunn, Kurko, & Bauman, 2011)...
November 17, 2016: Workplace Health & Safety
https://www.readbyqxmd.com/read/27821895/health-care-utilization-of-mexican-patients-with-medically-unexplained-physical-symptoms
#14
Azucena Maribel Rodriguez González, José Manuel Ramírez Aranda, Homero de Los Santos Reséndiz, María Yolanda Lara Duarte, Santiago Oscar Pazaran Zanella, Jafet Felipe Méndez López, Issa Gil Alfaro, Félix Gilberto Islas Ruz, Gloria Navarrete Floriano, Edith Guillen Salomón, Obdulia Texon Fernández, Silvia Cruz Duarte, Juan Carlos Romo Salazar, Claudia Elsa Pérez Ruiz, Sara de Jesús López Salas, Lizbeth Benítez Amaya, Javier Nahum Zapata Gallardo
OBJECTIVE: To determine the prevalence of medically unexplained physical symptoms and the characteristics and use of health services in a group of patients with medically unexplained physical symptoms and a group of patients with other illnesses. METHODS: This was a cross-sectional, retrospective and multicenter study. We included 1,043 patients over 18 years of age from 30 primary care units of a government health institution, in 11 states of Mexico, attended by 39 family physicians...
September 30, 2016: Colombia Médica: CM
https://www.readbyqxmd.com/read/27801908/metabolic-and-physiological-interdependencies-in-the-bathymodiolus-azoricus-symbiosis
#15
Ruby Ponnudurai, Manuel Kleiner, Lizbeth Sayavedra, Jillian M Petersen, Martin Moche, Andreas Otto, Dörte Becher, Takeshi Takeuchi, Noriyuki Satoh, Nicole Dubilier, Thomas Schweder, Stephanie Markert
The hydrothermal vent mussel Bathymodiolus azoricus lives in an intimate symbiosis with two types of chemosynthetic Gammaproteobacteria in its gills: a sulfur oxidizer and a methane oxidizer. Despite numerous investigations over the last decades, the degree of interdependence between the three symbiotic partners, their individual metabolic contributions, as well as the mechanism of carbon transfer from the symbionts to the host are poorly understood. We used a combination of proteomics and genomics to investigate the physiology and metabolism of the individual symbiotic partners...
November 1, 2016: ISME Journal
https://www.readbyqxmd.com/read/27795213/-clinic-of-humoral-primary-immunodeficiencies-in-adults-experience-in-a-tertiary-hospital
#16
Julio César Cambray-Gutiérrez, Diana Andrea Herrera-Sánchez, Lizbeth Blancas-Galicia, Patricia María O'Farrill-Romanillos
BACKGROUND: Primary immunodeficiencies (PID) are characterized by alteration of the components of the immune system. Humoral deficiencies represent 50%. The most common are selective IgA deficiency, Bruton agammaglobulinemia, and common variable immunodeficiency (CVID). OBJECTIVE: To describe the epidemiological and clinical characteristics of adults with humoral PID, cared for in a Primary Humoral Immunodeficiencies Clinic. METHODS: A descriptive cross-sectional study that included a year of analysis, including 35 patients with humoral PID, 31 with CVID, and 4 with Bruton agammaglobulinemia...
October 2016: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/27706391/-kidney-disease-in-colombia-priority-for-risk-management
#17
Lizbeth Acuña, Patricia Sánchez, Luis Alberto Soler, Luisa Fernanda Alvis
Objective To describe the demographic and clinical manifestations of patients with chronic kidney disease (CKD), arterial hypertension, and/or diabetes mellitus, and to determine the association between the presence of these pathologies and the development of CKD. Methods Analytic and cross-sectional study. The information, with a cutoff date of 30 June 2013, comes from the integrated database of CKD and patients with hypertension and diabetes, which the Colombian payer entities provided to the national fund for high-cost diseases (Cuenta de Alto Costo)...
August 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/27704767/boc3arg-linked-ligands-induce-degradation-by-localizing-target-proteins-to-the-20s-proteasome
#18
Yuntao Shi, Marcus J C Long, Masha M Rosenberg, Shican Li, Aimee Kobjack, Philip Lessans, Rory T Coffey, Lizbeth Hedstrom
Targeted protein degradation is a promising strategy for drug design and functional assessment. Several small molecule approaches have been developed that localize target proteins to ubiquitin ligases, inducing ubiquitination and subsequent degradation by the 26S proteasome. We discovered that the degradation of a target protein can also be induced by a recognition ligand linked to tert-butyl carbamate (Boc3)-protected arginine (B3A). Here, we show that this process requires the proteasome but does not involve ubiquitination of the target protein...
December 16, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27690147/phthalate-exposure-flavonoid-consumption-and-breast-cancer-risk-among-mexican-women
#19
Ángel Mérida-Ortega, César Hernández-Alcaraz, Raúl U Hernández-Ramírez, Angélica García-Martínez, Belem Trejo-Valdivia, Aarón Salinas-Rodríguez, Katherine Svensson, Mariano E Cebrián, Francisco Franco-Marina, Lizbeth López-Carrillo
OBJECTIVE: To evaluate if selected phthalate exposure and flavonoid intake interact on breast cancer (BC) risk. MATERIAL AND METHODS: Interviews and urine samples were obtained from 233 women with histologically confirmed BC and 221 healthy controls matched by age and place of residence, from various states of northern Mexico. Urinary metabolites concentrations of diethyl phthalate (DEP), butyl benzyl phthalate (BBzP) and dioctyl phthalate (DOP) were determined by solid-phase extraction coupled with high-performance liquid chromatography/isotope dilution/tandem mass spectrometry...
September 27, 2016: Environment International
https://www.readbyqxmd.com/read/27682202/novel-genotype-of-ehrlichia-canis-detected-in-samples-of-human-blood-bank-donors-in-costa-rica
#20
Laura Bouza-Mora, Gaby Dolz, Antony Solórzano-Morales, Juan José Romero-Zuñiga, Lizbeth Salazar-Sánchez, Marcelo B Labruna, Daniel M Aguiar
This study focuses on the detection and identification of DNA and antibodies to Ehrlichia spp. in samples of blood bank donors in Costa Rica using molecular and serological techniques. Presence of Ehrlichia canis was determined in 10 (3.6%) out of 280 blood samples using polymerase chain reaction (PCR) targeting the ehrlichial dsb conserved gene. Analysis of the ehrlichial trp36 polymorphic gene in these 10 samples revealed substantial polymorphism among the E. canis genotypes, including divergent tandem repeat sequences...
January 2017: Ticks and Tick-borne Diseases
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