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https://www.readbyqxmd.com/read/27860379/behavior-associated-neuronal-activation-after-kainic-acid-induced-hippocampal-neurotoxicity-is-modulated-in-time
#1
Andrea Aguilar-Arredondo, Fernanda López-Hernández, Lizbeth García-Velázquez, Clorinda Arias, Angélica Zepeda
Kainic acid-induced (KA) hippocampal damage leads to neuronal death and further synaptic plasticity. Formation of aberrant as well as of functional connections after such procedure has been documented. However, the impact of such structural plasticity on cell activation along time after damage and in face of a behavioral demand has not been explored. We evaluated if the mRNA and protein levels of plasticity-related protein synaptophysin (Syp and SYP, respectively) and activity-regulated cytoskeleton-associated protein mRNA and protein levels (Arc and Arc, respectively) in the dentate gyrus were differentially modulated in time in response to a spatial-exploratory task after KA-induced hippocampal damage...
November 11, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27856994/nurse-educators-occupational-and-leisure-sitting-time
#2
Lizbeth P Sturgeon, Dawn Garrett-Wright, Eve Main, Donna Blackburn, M Susan Jones
Prolonged sitting time (ST) is a risk factor for all-cause mortality, independent of physical activity. Nurse educators are particularly at risk due to limited physical activity, older age, and the increasing use of computers. This descriptive correlational study was designed to explore the ST of nurse educators in relation to their self-reported health status and general health indicators. A convenience sample of 56 nurse educators was recruited, and participants completed demographic items, general health questions, and the Workforce Sitting Questionnaire (WSQ; Chau, van der Ploeg, Dunn, Kurko, & Bauman, 2011)...
November 17, 2016: Workplace Health & Safety
https://www.readbyqxmd.com/read/27821895/health-care-utilization-of-mexican-patients-with-medically-unexplained-physical-symptoms
#3
Azucena Maribel Rodriguez González, José Manuel Ramírez Aranda, Homero de Los Santos Reséndiz, María Yolanda Lara Duarte, Santiago Oscar Pazaran Zanella, Jafet Felipe Méndez López, Issa Gil Alfaro, Félix Gilberto Islas Ruz, Gloria Navarrete Floriano, Edith Guillen Salomón, Obdulia Texon Fernández, Silvia Cruz Duarte, Juan Carlos Romo Salazar, Claudia Elsa Pérez Ruiz, Sara de Jesús López Salas, Lizbeth Benítez Amaya, Javier Nahum Zapata Gallardo
OBJECTIVE: To determine the prevalence of medically unexplained physical symptoms and the characteristics and use of health services in a group of patients with medically unexplained physical symptoms and a group of patients with other illnesses. METHODS: This was a cross-sectional, retrospective and multicenter study. We included 1,043 patients over 18 years of age from 30 primary care units of a government health institution, in 11 states of Mexico, attended by 39 family physicians...
September 30, 2016: Colombia Médica: CM
https://www.readbyqxmd.com/read/27801908/metabolic-and-physiological-interdependencies-in-the-bathymodiolus-azoricus-symbiosis
#4
Ruby Ponnudurai, Manuel Kleiner, Lizbeth Sayavedra, Jillian M Petersen, Martin Moche, Andreas Otto, Dörte Becher, Takeshi Takeuchi, Noriyuki Satoh, Nicole Dubilier, Thomas Schweder, Stephanie Markert
The hydrothermal vent mussel Bathymodiolus azoricus lives in an intimate symbiosis with two types of chemosynthetic Gammaproteobacteria in its gills: a sulfur oxidizer and a methane oxidizer. Despite numerous investigations over the last decades, the degree of interdependence between the three symbiotic partners, their individual metabolic contributions, as well as the mechanism of carbon transfer from the symbionts to the host are poorly understood. We used a combination of proteomics and genomics to investigate the physiology and metabolism of the individual symbiotic partners...
November 1, 2016: ISME Journal
https://www.readbyqxmd.com/read/27795213/-clinic-of-humoral-primary-immunodeficiencies-in-adults-experience-in-a-tertiary-hospital
#5
Julio César Cambray-Gutiérrez, Diana Andrea Herrera-Sánchez, Lizbeth Blancas-Galicia, Patricia María O'Farrill-Romanillos
BACKGROUND: Primary immunodeficiencies (PID) are characterized by alteration of the components of the immune system. Humoral deficiencies represent 50%. The most common are selective IgA deficiency, Bruton agammaglobulinemia, and common variable immunodeficiency (CVID). OBJECTIVE: To describe the epidemiological and clinical characteristics of adults with humoral PID, cared for in a Primary Humoral Immunodeficiencies Clinic. METHODS: A descriptive cross-sectional study that included a year of analysis, including 35 patients with humoral PID, 31 with CVID, and 4 with Bruton agammaglobulinemia...
October 2016: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/27706391/-kidney-disease-in-colombia-priority-for-risk-management
#6
Lizbeth Acuña, Patricia Sánchez, Luis Alberto Soler, Luisa Fernanda Alvis
Objective To describe the demographic and clinical manifestations of patients with chronic kidney disease (CKD), arterial hypertension, and/or diabetes mellitus, and to determine the association between the presence of these pathologies and the development of CKD. Methods Analytic and cross-sectional study. The information, with a cutoff date of 30 June 2013, comes from the integrated database of CKD and patients with hypertension and diabetes, which the Colombian payer entities provided to the national fund for high-cost diseases (Cuenta de Alto Costo)...
August 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/27704767/boc3arg-linked-ligands-induce-degradation-by-localizing-target-proteins-to-the-20s-proteasome
#7
Yuntao Shi, Marcus J C Long, Masha M Rosenberg, Shican Li, Aimee Kobjack, Philip Lessans, Rory T Coffey, Lizbeth Hedstrom
Targeted protein degradation is a promising strategy for drug design and functional assessment. Several small molecule approaches have been developed that localize target proteins to ubiquitin ligases, inducing ubiquitination and subsequent degradation by the 26S proteasome. We discovered that the degradation of a target protein can also be induced by a recognition ligand linked to tert-butyl carbamate (Boc3)-protected arginine (B3A). Here we show that this process requires the proteasome, but does not involve ubiquitination of the target protein...
October 5, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27690147/phthalate-exposure-flavonoid-consumption-and-breast-cancer-risk-among-mexican-women
#8
Ángel Mérida-Ortega, César Hernández-Alcaraz, Raúl U Hernández-Ramírez, Angélica García-Martínez, Belem Trejo-Valdivia, Aarón Salinas-Rodríguez, Katherine Svensson, Mariano E Cebrián, Francisco Franco-Marina, Lizbeth López-Carrillo
OBJECTIVE: To evaluate if selected phthalate exposure and flavonoid intake interact on breast cancer (BC) risk. MATERIAL AND METHODS: Interviews and urine samples were obtained from 233 women with histologically confirmed BC and 221 healthy controls matched by age and place of residence, from various states of northern Mexico. Urinary metabolites concentrations of diethyl phthalate (DEP), butyl benzyl phthalate (BBzP) and dioctyl phthalate (DOP) were determined by solid-phase extraction coupled with high-performance liquid chromatography/isotope dilution/tandem mass spectrometry...
September 27, 2016: Environment International
https://www.readbyqxmd.com/read/27682202/novel-genotype-of-ehrlichia-canis-detected-in-samples-of-human-blood-bank-donors-in-costa-rica
#9
Laura Bouza-Mora, Gaby Dolz, Antony Solórzano-Morales, Juan José Romero-Zuñiga, Lizbeth Salazar-Sánchez, Marcelo B Labruna, Daniel M Aguiar
This study focuses on the detection and identification of DNA and antibodies to Ehrlichia spp. in samples of blood bank donors in Costa Rica using molecular and serological techniques. Presence of Ehrlichia canis was determined in 10 (3.6%) out of 280 blood samples using polymerase chain reaction (PCR) targeting the ehrlichial dsb conserved gene. Analysis of the ehrlichial trp36 polymorphic gene in these 10 samples revealed substantial polymorphism among the E. canis genotypes, including divergent tandem repeat sequences...
January 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27670799/a-population-wide-applicable-hla-dq2-and-dq8-genotyping-using-dna-from-dried-blood-spots-and-duplex-allele-specific-qpcr-amplification
#10
Sandra Aguayo-Patrón, Lizbeth Beltrán-Sauceda, Ana María Calderón de la Barca
Genotyping of HLA-DQ2 and DQ8 haplotypes is important for diagnosis or for screening of early risk detection of celiac disease or type 1 diabetes. Usually, venous blood DNA extraction and expensive and time consuming amplification are used, that hinder population-wide studies. We assayed a friendly HLA-DQ2 and DQ8 genotyping procedure using a combination of DNA from dried blood spot (DBS) and duplex allele-specific qPCR amplification using SYBR Green. DNA was extracted using home-made buffers and compared to an extraction commercial kit...
November 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27670072/retinaldehyde-dehydrogenase-2-as-a-molecular-adjuvant-for-enhancement-of-mucosal-immunity-during-dna-vaccination
#11
Susan A Holechek, Megan S McAfee, Lizbeth M Nieves, Vanessa P Guzman, Kavita Manhas, Timothy Fouts, Kenneth Bagley, Joseph N Blattman
In order for vaccines to induce efficacious immune responses against mucosally transmitted pathogens, such as HIV-1, activated lymphocytes must efficiently migrate to and enter targeted mucosal sites. We have previously shown that all-trans retinoic acid (ATRA) can be used as a vaccine adjuvant to enhance mucosal CD8(+) T cell responses during vaccination and improve protection against mucosal viral challenge. However, the ATRA formulation is incompatible with most recombinant vaccines, and the teratogenic potential of ATRA at high doses limits its usage in many clinical settings...
November 4, 2016: Vaccine
https://www.readbyqxmd.com/read/27623023/branch-selective-hydroarylation-iodoarene-olefin-cross-coupling
#12
Samantha A Green, Jeishla L M Matos, Akiko Yagi, Ryan A Shenvi
A combination of cobalt and nickel catalytic cycles enables a highly branch-selective (Markovnikov) olefin hydroarylation. Radical cyclization and ring scission experiments are consistent with hydrogen atom transfer (HAT) generation of a carbon-centered radical that leads to engagement of a nickel cycle.
October 5, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27621734/cassava-breeding-i-the-value-of-breeding-value
#13
Hernán Ceballos, Juan C Pérez, Orlando Joaqui Barandica, Jorge I Lenis, Nelson Morante, Fernando Calle, Lizbeth Pino, Clair H Hershey
Breeding cassava relies on several selection stages (single row trial-SRT; preliminary; advanced; and uniform yield trials-UYT). This study uses data from 14 years of evaluations. From more than 20,000 genotypes initially evaluated only 114 reached the last stage. The objective was to assess how the data at SRT could be used to predict the probabilities of genotypes reaching the UYT. Phenotypic data from each genotype at SRT was integrated into the selection index (SIN) used by the cassava breeding program...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27613871/substrate-and-cofactor-dynamics-on-guanosine-monophosphate-reductase-probed-by-high-resolution-field-cycling-31p-nmr-relaxometry
#14
Masha M Rosenberg, Alfred G Redfield, Mary F Roberts, Lizbeth Hedstrom
Guanosine-5'-monophosphate reductase (GMPR) catalyzes the reduction of GMP to IMP and ammonia with concomitant oxidation of NADPH. Here we investigated the structure and dynamics of enzyme-bound substrates and cofactors by measuring (31)P relaxation rates over a large magnetic field range using high resolution field cycling NMR relaxometry. Surprisingly, these experiments reveal differences in the low field relaxation profiles for the monophosphate of GMP compared with IMP in their respective NADP(+) complexes...
October 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27578623/the-ire1-bzip60-pathway-and-bax-inhibitor-1-suppress-systemic-accumulation-of-potyviruses-and-potexviruses-in-arabidopsis-and-n-benthamiana-plants
#15
Omar Paul Arias Gaguancela, Lizbeth Peña Zúñiga, Alexis Vela Arias, Dennis Halterman, Francisco Javier Flores, Ida Elisabeth Johansen, Aiming Wang, Yasuyuki Yamaji, Jeanmarie Verchot-Lubicz
The inositol requiring enzyme (IRE1) is an endoplasmic reticulum (ER) stress sensor. When activated, it splices the bZIP60 mRNA producing a truncated transcription factor that upregulates genes involved in the unfolded protein response (UPR). Bax inhibitor 1 (BI-1) is another ER stress sensor that regulates cell death in response to environmental assaults. The potyvirus 6K2 and potexvirus TGB3 proteins are known to reside in the ER, serving respectively as anchors for the viral replicase and movement protein complex...
August 31, 2016: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/27565879/dietary-micronutrient-intake-and-its-relationship-with-arsenic-metabolism-in-mexican-women
#16
Lizbeth López-Carrillo, Brenda Gamboa-Loira, Wendy Becerra, César Hernández-Alcaraz, Raúl Ulises Hernández-Ramírez, A Jay Gandolfi, Francisco Franco-Marina, Mariano E Cebrián
INTRODUCTION: Concentrations of inorganic arsenic (iAs) metabolites in urine present intra- and interindividual variations, which are determined not only by the magnitude of exposure to iAs, but also by differences in genetic, environmental and dietary factors. OBJECTIVE: To evaluate whether differences in dietary intake of selected micronutrients are associated with the metabolism of iAs. METHODS: The intake of 21 micronutrients was estimated for 1027 women living in northern Mexico using a food frequency questionnaire...
August 23, 2016: Environmental Research
https://www.readbyqxmd.com/read/27558111/the-hmgb1-c-terminal-tail-regulates-dna-bending
#17
Rebecca H Blair, Abigail E Horn, Yogitha Pazhani, Lizbeth Grado, James A Goodrich, Jennifer F Kugel
High mobility group box protein 1 (HMGB1) is an architectural protein that facilitates the formation of protein-DNA assemblies involved in transcription, recombination, DNA repair, and chromatin remodeling. Important to its function is the ability of HMGB1 to bend DNA non-sequence specifically. HMGB1 contains two HMG boxes that bind and bend DNA (the A box and the B box) and a C-terminal acidic tail. We investigated how these domains contribute to DNA bending by HMGB1 using single-molecule fluorescence resonance energy transfer (FRET), which enabled us to resolve heterogeneous populations of bent and unbent DNA...
October 9, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27557380/genetic-polymorphisms-of-ppar-gamma-arsenic-methylation-capacity-and-breast-cancer-risk-in-mexican-women
#18
Cristina P Pineda-Belmontes, Raúl U Hernández-Ramírez, César Hernández-Alcaraz, Mariano E Cebrián, Lizbeth López-Carrillo
OBJECTIVE: To evaluate whether the presence of polymorphisms of peroxisome proliferator-activated receptor gamma PPARγ (Pro 1 2Ala) and PPARGC1B (Ala203Pro) modifies the association between the inorganic arsenic (iAs) methylation capacity and breast cancer (BC). MATERIALS AND METHODS: Mexican women were interviewed, and blood and urine samples were collected from them (cases/controls= 197/220). The concentration of urinary arsenic species and the polymorphisms of interest were determined by high-performance liquid chromatography with inductively coupled plasma mass spectrometry (HPLC-ICP-MS) and polymerase chain reaction (PCR), respectively...
April 2016: Salud Pública de México
https://www.readbyqxmd.com/read/27541177/inhibition-of-inosine-5-monophosphate-dehydrogenase-from-bacillus-anthracis-mechanism-revealed-by-pre-steady-state-kinetics
#19
Yang Wei, Petr Kuzmič, Runhan Yu, Gyan Modi, Lizbeth Hedstrom
Inosine-5'-monophosphate dehydrogenase (IMPDH) catalyzes the conversion of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP). The enzyme is an emerging target for antimicrobial therapy. The small molecule inhibitor A110 has been identified as a potent and selective inhibitor of IMPDHs from a variety of pathogenic microorganisms. A recent X-ray crystallographic study reported that the inhibitor binds to the NAD(+) cofactor site and forms a ternary complex with IMP. Here we report a pre-steady-state stopped-flow kinetic investigation of IMPDH from Bacillus anthracis designed to assess the kinetic significance of the crystallographic results...
September 20, 2016: Biochemistry
https://www.readbyqxmd.com/read/27524776/views-on-hpv-and-hpv-vaccination-the-experience-at-a-federal-qualified-clinic-in-puerto-rico
#20
Vivian Colón-López, Lizbeth M Toro-Mejías, Alexandra Conde-Toro, Michelle J Serra-Rivera, Tania M Martínez, Verónica Rodríguez, Ana M Ríos, Luis Berdiel, Héctor Villanueva
OBJECTIVE: The purpose of this study was to understand through a quantitative assessment, the views of HPV and HPV vaccination among parents of sons from a FQHC in PR. METHODS: A self-administered questionnaire was given to a convenience sample of 200 parents of sons 9-17 years old. RESULTS: Nearly 30% of the parents reported that their sons had initiated the HPV vaccine regimen. Health care provider recommendation was significantly associated with vaccine initiation...
2016: Journal of Health Care for the Poor and Underserved
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