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https://www.readbyqxmd.com/read/28433864/arsenic-metabolism-and-cancer-risk-a-meta-analysis
#1
REVIEW
Brenda Gamboa-Loira, Mariano E Cebrián, Francisco Franco-Marina, Lizbeth López-Carrillo
OBJECTIVE: To describe the studies that have reported association measures between risk of cancer and the percentage distribution of urinary inorganic arsenic (iAs) metabolites by anatomical site, in non-ecological epidemiological studies. METHODS: Studies were identified in the PubMed database in the period from 1990 to 2015. Inclusion criteria were: non-ecological epidemiological study, with histologically confirmed cancer cases, reporting the percentage distribution of inorganic arsenic (iAs), monomethylated (MMA) and dimethylated (DMA) metabolites, as well as association measures with confidence intervals (CI) between cancer and %iAs and/or %MMA and/or %DMA...
April 20, 2017: Environmental Research
https://www.readbyqxmd.com/read/28428948/understanding-the-entanglement-neutrophil-extracellular-traps-nets-in-cystic-fibrosis
#2
REVIEW
Saira R Martínez-Alemán, Lizbeth Campos-García, José P Palma-Nicolas, Romel Hernández-Bello, Gloria M González, Alejandro Sánchez-González
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the gene that codes for the CF trans-membrane conductance regulator. These mutations result in abnormal secretions viscous airways of the lungs, favoring pulmonary infection and inflammation in the middle of neutrophil recruitment. Recently it was described that neutrophils can contribute with disease pathology by extruding large amounts of nuclear material through a mechanism of cell death known as Neutrophil Extracellular Traps (NETs) into the airways of patients with CF...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28423364/increased-expression-of-deleted-in-malignant-brain-tumors-dmbt1-gene-in-precancerous-gastric-lesions-findings-from-human-and-animal-studies
#3
Jone Garay, M Blanca Piazuelo, Lizbeth Lopez-Carrillo, Yelda A Leal, Sumana Majumdar, Li Li, Nataly Cruz-Rodriguez, Silvia J Serrano-Gomez, Carlos S Busso, Barbara G Schneider, Alberto G Delgado, Luis E Bravo, Angela M Crist, Stryder M Meadows, M Constanza Camargo, Keith T Wilson, Pelayo Correa, Jovanny Zabaleta
Helicobacter pylori infection triggers a cascade of inflammatory stages that may lead to the appearance of non-atrophic gastritis, multifocal atrophic, intestinal metaplasia, dysplasia, and cancer. Deleted in malignant brain tumors 1 (DMBT1) belongs to the group of secreted scavenger receptor cysteine-rich proteins and is considered to be involved in host defense by binding to pathogens. Initial studies showed its deletion and loss of expression in a variety of tumors but the role of this gene in tumor development is not completely understood...
April 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421779/oral-glutamine-reduces-myocardial-damage-after-coronary-revascularization-under-cardiopulmonary-bypass-a-randomized-clinical-trial
#4
Mariana Chávez-Tostado, Fernando Carrillo-Llamas, Porfirio Eduardo Martínez-Gutiérrez, Araceli Alvarado-Ramírez, Jaime Gilberto López-Taylor, José Clemente Vásquez-Jiménez, Clotilde Fuentes-Orozco, Jorge Rendón-Félix, Leire Irusteta-Jiménez, Vanessa Carolina Calil-Romero, José Antonio Ramírez-Jiménez, Luis Rodrigo Michel-Espinoza, Carmen Karina Contreras-López, Lizbeth Araceli Cuesta-Márquez, Alejandro González-Ojeda
BACKGROUND: Glutamine is the most abundant free amino acid in the body. It modulates immune cell function and is an important energy substrate for cells in critically ill patients. Reduction of injury cardiac markers had been observed in patients receiving intravenous glutamine and in a pilot study with oral glutamine. The aim of this study was to analyze the effect of preoperative oral supplementation of glutamine on postoperative serum levels of cardiac injury markers. METHODS: A randomized clinical trial was performed in 28 Mexican patients with ischemic heart disease who underwent cardiopulmonary bypass with extracorporeal circulation...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28379556/fusing-biodiversity-metrics-into-investigations-of-daily-life-illustrations-and-recommendations-with-emodiversity
#5
Lizbeth Benson, Nilam Ram, David M Almeida, Alex J Zautra, Anthony D Ong
Objectives: Functionalist emotion and ecological systems theories suggest emodiversity-the variety and relative abundance of individuals' emotion experiences-is beneficial for psychological and physical health and may change with age. This paper examines and provides recommendations for operationalization of diversity-type intraindividual variability (IIV) constructs using intensive longitudinal data, and demonstrates the utility of emodiversity by examining its links to physical health moderated by mean levels of emotion and age...
March 30, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28337332/bms-933043-a-selective-%C3%AE-7-nachr-partial-agonist-for-the-treatment-of-cognitive-deficits-associated-with-schizophrenia
#6
Dalton King, Christiana Iwuagwu, Jim Cook, Ivar M McDonald, Robert Mate, F Christopher Zusi, Matthew D Hill, Haiquan Fang, Rulin Zhao, Bei Wang, Amy E Easton, Regina Miller, Debra Post-Munson, Ronald J Knox, Lizbeth Gallagher, Ryan Westphal, Thaddeus Molski, Jingsong Fan, Wendy Clarke, Yulia Benitex, Kimberley A Lentz, Rex Denton, Daniel Morgan, Robert Zaczek, Nicholas J Lodge, Linda J Bristow, John E Macor, Richard E Olson
The therapeutic treatment of negative symptoms and cognitive dysfunction associated with schizophrenia is a significant unmet medical need. Preclinical literature indicates that α7 neuronal nicotinic acetylcholine (nACh) receptor agonists may provide an effective approach to treating cognitive dysfunction in schizophrenia. We report herein the discovery and evaluation of 1c (BMS-933043), a novel and potent α7 nACh receptor partial agonist with high selectivity against other nicotinic acetylcholine receptor subtypes (>100-fold) and the 5-HT3A receptor (>300-fold)...
March 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28336403/broad-analysis-of-vicinal-disulfides-occurrences-conformations-with-cis-or-with-trans-peptides-and-functional-roles-including-sugar-binding
#7
Jane S Richardson, Lizbeth L Videau, Christopher J Williams, David C Richardson
Vicinal disulfides between sequence-adjacent cysteine residues are very rare and rather startling structural features which play a variety of functional roles. Typically discussed as an isolated curiosity, they have never received a general treatment covering both cis and trans forms. Enabled by the growing database of high-resolution structures, required deposition of diffraction data, and improved methods for discriminating reliable from dubious cases, we identify and describe distinct protein families with reliably genuine examples of cis or trans vicinal disulfides and discuss their conformations, conservation, and functions...
March 20, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28329860/modeling-intraindividual-dynamics-using-stochastic-differential-equations-age-differences-in-affect-regulation
#8
Julie Wood, Zita Oravecz, Nina Vogel, Lizbeth Benson, Sy-Miin Chow, Pamela Cole, David E Conroy, Aaron L Pincus, Nilam Ram
Objectives: Life-span theories of aging suggest improvements and decrements in individuals' ability to regulate affect. Dynamic process models, with intensive longitudinal data, provide new opportunities to articulate specific theories about individual differences in intraindividual dynamics. This paper illustrates a method for operationalizing affect dynamics using a multilevel stochastic differential equation (SDE) model, and examines how those dynamics differ with age and trait-level tendencies to deploy emotion regulation strategies (reappraisal and suppression)...
March 2, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28325442/a-two-stage-variable-selection-and-classification-approach-for-parkinson-s-disease-detection-by-using-voice-recording-replications
#9
Lizbeth Naranjo, Carlos J Pérez, Jacinto Martín, Yolanda Campos-Roca
BACKGROUND AND OBJECTIVE: In the scientific literature, there is a lack of variable selection and classification methods considering replicated data. The problem motivating this work consists in the discrimination of people suffering Parkinson's disease from healthy subjects based on acoustic features automatically extracted from replicated voice recordings. METHODS: A two-stage variable selection and classification approach has been developed to properly match the replication-based experimental design...
April 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28262839/loss-of-the-eph-receptor-b6-contributes-to-colorectal-cancer-metastasis
#10
Silvia Mateo-Lozano, Sarah Bazzocco, Paulo Rodrigues, Rocco Mazzolini, Elena Andretta, Higinio Dopeso, Yolanda Fernández, Edgar Del Llano, Josipa Bilic, Lucía Suárez-López, Irati Macaya, Fernando Cartón-García, Rocio Nieto, Lizbeth M Jimenez-Flores, Priscila Guimarães de Marcondes, Yaiza Nuñez, Elsa Afonso, Karina Cacci, Javier Hernández-Losa, Stefania Landolfi, Ibane Abasolo, Santiago Ramón Y Cajal, John M Mariadason, Simo Schwartz, Toshimitsu Matsui, Diego Arango
Although deregulation of EPHB signaling has been shown to be an important step in colorectal tumorigenesis, the role of EPHB6 in this process has not been investigated. We found here that manipulation of EPHB6 levels in colon cancer cell lines has no effect on their motility and growth on a solid substrate, soft agar or in a xenograft mouse model. We then used an EphB6 knockout mouse model to show that EphB6 inactivation does not efficiently initiate tumorigenesis in the intestinal tract. In addition, when intestinal tumors are initiated genetically or pharmacologically in EphB6(+/+) and EphB6(-/-) mice, no differences were observed in animal survival, tumor multiplicity, size or histology, and proliferation of intestinal epithelial cells or tumor cells...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28242175/epidemiology-of-early-stages-of-epilepsy-risk-of-seizure-recurrence-after-a-first-seizure
#11
REVIEW
Syed Rizvi, Lady Diana Ladino, Lizbeth Hernandez-Ronquillo, José F Téllez-Zenteno
A single unprovoked seizure is a frequent phenomenon in the general population and the rate of seizure recurrence can vary widely. Individual risk prognostication is crucial in predicting patient outcomes and guiding treatment decisions. In this article, we review the most important risk factors associated with an increased likelihood of seizure recurrence after a single unprovoked seizure. In summary, the presence of focal seizure, nocturnal seizure, history of prior brain injury, family history of epilepsy, abnormal neurological exam, epileptiform discharges on electroencephalography and neuroimaging abnormalities, portend increased risk of seizure recurrence...
February 14, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28236448/gradual-decrease-in-spermatogenesis-caused-by-chronic-stress
#12
Lizbeth Juárez-Rojas, Rosa María Vigueras-Villaseñor, Fahiel Casillas, Socorro Retana-Márquez
Chronic stress induces decreased sperm motility, viability and concentration in stressed males. Also, stress modifies oxidative status and causes apoptosis in testes, as well as a decrease in the epithelial area of seminiferous tubules. However, there are no studies that analyze the alterations caused by stress in testicular cells. Thus, in this study, alterations in the morphology of testicular germ cells caused by different days of chronic stress were assessed. Adult male rats were exposed to stress by immersion in cold water (ICW) daily for 3, 8, 20 or 50 consecutive days...
February 21, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28230929/investigation-of-p16-status-chemotherapy-regimen-and-other-nutrition-markers-for-predicting-gastrostomy-in-patients-with-head-and-neck-cancer
#13
Teresa E Brown, Kym Wittholz, Mandy Way, Merrilyn D Banks, Brett G M Hughes, Charles Y Lin, Lizbeth M Kenny, Judith D Bauer
BACKGROUND: The purpose of this study was to determine if p16 status, chemotherapy regimen, or other nutrition markers could improve protocol accuracy in predicting proactive gastrostomy in patients with head and neck cancer. METHODS: Patients who received curative treatment from July 2010 to June 2011 were included (n = 269). Associations among dependent variables (age, sex, tumor site, staging, treatment, p16 status, albumin, and Malnutrition Screening Tool [MST] score), the protocol risk rating, and requirement for proactive gastrostomy were examined...
February 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28225567/randomized-controlled-trial-of-a-multisite-speech-pathology-telepractice-service-providing-swallowing-and-communication-intervention-to-patients-with-head-and-neck-cancer-evaluation-of-service-outcomes
#14
Clare L Burns, Elizabeth C Ward, Anne J Hill, Sanjeewa Kularatna, Joshua Byrnes, Lizbeth M Kenny
BACKGROUND: The purpose of this study was to present our evaluation of a new speech pathology telepractice service supporting the swallowing and communication management of patients with head and neck cancer. METHODS: A multicenter randomized controlled trial was conducted within a large public cancer service. Referrals from speech pathologists at 3 regional sites (spoke sites) were managed by a specialist clinician from a cancer center (hub site) either via standard care (phone/email support/appointments at the hub site) or a newly established telepractice service (online consultation between the hub site and spoke site)...
February 22, 2017: Head & Neck
https://www.readbyqxmd.com/read/28223451/mycobacterium-tuberculosis-proteasome-accessory-factor-a-pafa-can-transfer-prokaryotic-ubiquitin-like-protein-pup-between-substrates
#15
Susan Zhang, Kristin E Burns-Huang, Guido V Janssen, Huilin Li, Huib Ovaa, Lizbeth Hedstrom, K Heran Darwin
The protein degradation machinery of Mycobacterium tuberculosis includes a proteasome and a ubiquitin-like protein (Pup). Proteasome accessory factor A (PafA) attaches Pup to proteins to target them for degradation by the proteasome. Free Pup is unstable and never observed in extracts of M. tuberculosis, an observation that led us to hypothesize that PafA may need alternative sources of Pup. Here, we show that PafA can move Pup from one proteasome substrate, inositol 1-phosphate synthetase (Ino1), to two different proteins, malonyl coenzyme A (CoA)-acyl carrier protein transacylase (FabD) and lonely guy (Log)...
February 21, 2017: MBio
https://www.readbyqxmd.com/read/28222127/unusual-pattern-of-chikungunya-virus-epidemic-in-the-americas-the-panamanian-experience
#16
Jean-Paul Carrera, Yamilka Díaz, Bernardino Denis, Itza Barahona de Mosca, Dennys Rodriguez, Israel Cedeño, Dimelza Arauz, Publio González, Lizbeth Cerezo, Lourdes Moreno, Lourdes García, Lisseth E Sáenz, María Aneth Atencio, Eddy Rojas-Fermin, Fernando Vizcaino, Nicolas Perez, Brechla Moreno, Sandra López-Vergès, Anayansi Valderrama, Blas Armién
BACKGROUND: Chikungunya virus (CHIKV) typically causes explosive epidemics of fever, rash and polyarthralgia after its introduction into naïve populations. Since its introduction in Panama in May of 2014, few autochthonous cases have been reported; most of them were found within limited outbreaks in Panama City in 2014 and Puerto Obaldia town, near the Caribbean border with Colombia in 2015. In order to confirm that Panama had few CHIKV cases compared with neighboring countries, we perform an epidemiological analysis of chikungunya cases reported from May 2014 to July 2015...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28191951/rearranged-terpenoids-from-the-marine-sponge-darwinella-cf-oxeata-and-its-predator-the-nudibranch-felimida-grahami
#17
Maria Camila A Ramirez, David E Williams, Juliana R Gubiani, Lizbeth L L Parra, Mario F C Santos, Daiane D Ferreira, Juliana T Mesquita, Andre G Tempone, Antonio G Ferreira, Vinícius Padula, Eduardo Hajdu, Raymond J Andersen, Roberto G S Berlinck
Marine sponges are a rich source of terpenoids with rearranged spongian carbon skeletons. Investigation of extracts from the sponge Darwinella cf. oxeata yielded four new rearranged diterpenoids, oxeatine (2) and oxeatamides H-J (3-5), as well as the known metabolites oxeatamide A (6), oxeatamide A methyl ester (7), and membranolide (1). Oxeatine (2) has a new heterocyclic skeleton, while oxeatamide J (5) has an N-methyl urea group included in a γ-lactam moiety. UPLC-QTOF analysis of the extract obtained from the mantle of the nudibranch Felimida grahami indicated the presence of 1 and 4...
February 13, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28169277/investigation-of-the-role-of-tyrosine-kinase-receptor-epha3-in-colorectal-cancer
#18
Elena Andretta, Fernando Cartón-García, Águeda Martínez-Barriocanal, Priscila Guimarães de Marcondes, Lizbeth M Jimenez-Flores, Irati Macaya, Sarah Bazzocco, Josipa Bilic, Paulo Rodrigues, Rocio Nieto, Stefania Landolfi, Santiago Ramon Y Cajal, Simo Schwartz, Arthur Brown, Higinio Dopeso, Diego Arango
EPH signaling deregulation has been shown to be important for colorectal carcinogenesis and genome-wide sequencing efforts have identified EPHA3 as one of the most frequently mutated genes in these tumors. However, the role of EPHA3 in colorectal cancer has not been thoroughly investigated. We show here that ectopic expression of wild type EPHA3 in colon cancer cells did not affect their growth, motility/invasion or metastatic potential in vivo. Moreover, overexpression of mutant EPHA3 or deletion of the endogenous mutant EPHA3 in colon cancer cells did not affect their growth or motility...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28169167/design-and-synthesis-of-a-novel-series-of-4-heteroarylamino-1-azaspiro-oxazole-5-3-bicyclo-2-2-2-octanes-as-%C3%AE-7-nicotinic-receptor-agonists-2-development-of-4-heteroaryl-sar
#19
Christiana Iwuagwu, Dalton King, Ivar M McDonald, James Cook, F Christopher Zusi, Matthew D Hill, Robert A Mate, Haiquan Fang, Ronald Knox, Lizbeth Gallagher, Debra Post-Munson Amy Easton, Regina Miller, Yulia Benitex, Judy Siuciak, Nicholas Lodge, Robert Zaczek, Daniel Morgan, Linda Bristow, John E Macor, Richard E Olson
Quinuclidine-containing spirooxazolines, as described in the previous report in this series, were demonstrated to have utility as α7 nicotinic acetylcholine receptor (α7 nAChR) partial agonists. In this work, the SAR of this chemotype was expanded to include an array of diazine heterocyclic substitutions. Many of the heterocyclic analogs were potent partial agonists of the α7 receptor, selective against other nicotinic receptors and the serotinergic 5HT3A receptor. (1'S,3'R,4'S)-N-(6-phenylpyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2...
January 20, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28138419/paramyxovirus-glycoproteins-and-the-membrane-fusion-process
#20
Hector C Aguilar, Bryce A Henderson, J Lizbeth Zamora, Gunner P Johnston
The family Paramyxoviridae includes many viruses that significantly affect human and animal health. An essential step in the paramyxovirus life cycle is viral entry into host cells, mediated by virus-cell membrane fusion. Upon viral entry, infection results in expression of the paramyxoviral glycoproteins on the infected cell surface. This can lead to cell-cell fusion (syncytia formation), often linked to pathogenesis. Thus membrane fusion is essential for both viral entry and cell-cell fusion and an attractive target for therapeutic development...
September 2016: Current Clinical Microbiology Reports
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