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https://www.readbyqxmd.com/read/28230929/investigation-of-p16-status-chemotherapy-regimen-and-other-nutrition-markers-for-predicting-gastrostomy-in-patients-with-head-and-neck-cancer
#1
Teresa E Brown, Kym Wittholz, Mandy Way, Merrilyn D Banks, Brett G M Hughes, Charles Y Lin, Lizbeth M Kenny, Judith D Bauer
BACKGROUND: The purpose of this study was to determine if p16 status, chemotherapy regimen, or other nutrition markers could improve protocol accuracy in predicting proactive gastrostomy in patients with head and neck cancer. METHODS: Patients who received curative treatment from July 2010 to June 2011 were included (n = 269). Associations among dependent variables (age, sex, tumor site, staging, treatment, p16 status, albumin, and Malnutrition Screening Tool [MST] score), the protocol risk rating, and requirement for proactive gastrostomy were examined...
February 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28225567/randomized-controlled-trial-of-a-multisite-speech-pathology-telepractice-service-providing-swallowing-and-communication-intervention-to-patients-with-head-and-neck-cancer-evaluation-of-service-outcomes
#2
Clare L Burns, Elizabeth C Ward, Anne J Hill, Sanjeewa Kularatna, Joshua Byrnes, Lizbeth M Kenny
BACKGROUND: The purpose of this study was to present our evaluation of a new speech pathology telepractice service supporting the swallowing and communication management of patients with head and neck cancer. METHODS: A multicenter randomized controlled trial was conducted within a large public cancer service. Referrals from speech pathologists at 3 regional sites (spoke sites) were managed by a specialist clinician from a cancer center (hub site) either via standard care (phone/email support/appointments at the hub site) or a newly established telepractice service (online consultation between the hub site and spoke site)...
February 22, 2017: Head & Neck
https://www.readbyqxmd.com/read/28223451/mycobacterium-tuberculosis-proteasome-accessory-factor-a-pafa-can-transfer-prokaryotic-ubiquitin-like-protein-pup-between-substrates
#3
Susan Zhang, Kristin E Burns-Huang, Guido V Janssen, Huilin Li, Huib Ovaa, Lizbeth Hedstrom, K Heran Darwin
The protein degradation machinery of Mycobacterium tuberculosis includes a proteasome and a ubiquitin-like protein (Pup). Proteasome accessory factor A (PafA) attaches Pup to proteins to target them for degradation by the proteasome. Free Pup is unstable and never observed in extracts of M. tuberculosis, an observation that led us to hypothesize that PafA may need alternative sources of Pup. Here, we show that PafA can move Pup from one proteasome substrate, inositol 1-phosphate synthetase (Ino1), to two different proteins, malonyl coenzyme A (CoA)-acyl carrier protein transacylase (FabD) and lonely guy (Log)...
February 21, 2017: MBio
https://www.readbyqxmd.com/read/28222127/unusual-pattern-of-chikungunya-virus-epidemic-in-the-americas-the-panamanian-experience
#4
Jean-Paul Carrera, Yamilka Díaz, Bernardino Denis, Itza Barahona de Mosca, Dennys Rodriguez, Israel Cedeño, Dimelza Arauz, Publio González, Lizbeth Cerezo, Lourdes Moreno, Lourdes García, Lisseth E Sáenz, María Aneth Atencio, Eddy Rojas-Fermin, Fernando Vizcaino, Nicolas Perez, Brechla Moreno, Sandra López-Vergès, Anayansi Valderrama, Blas Armién
BACKGROUND: Chikungunya virus (CHIKV) typically causes explosive epidemics of fever, rash and polyarthralgia after its introduction into naïve populations. Since its introduction in Panama in May of 2014, few autochthonous cases have been reported; most of them were found within limited outbreaks in Panama City in 2014 and Puerto Obaldia town, near the Caribbean border with Colombia in 2015. In order to confirm that Panama had few CHIKV cases compared with neighboring countries, we perform an epidemiological analysis of chikungunya cases reported from May 2014 to July 2015...
February 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28191951/rearranged-terpenoids-from-the-marine-sponge-darwinella-cf-oxeata-and-its-predator-the-nudibranch-felimida-grahami
#5
Maria Camila A Ramirez, David E Williams, Juliana R Gubiani, Lizbeth L L Parra, Mario F C Santos, Daiane D Ferreira, Juliana T Mesquita, Andre G Tempone, Antonio G Ferreira, Vinícius Padula, Eduardo Hajdu, Raymond J Andersen, Roberto G S Berlinck
Marine sponges are a rich source of terpenoids with rearranged spongian carbon skeletons. Investigation of extracts from the sponge Darwinella cf. oxeata yielded four new rearranged diterpenoids, oxeatine (2) and oxeatamides H-J (3-5), as well as the known metabolites oxeatamide A (6), oxeatamide A methyl ester (7), and membranolide (1). Oxeatine (2) has a new heterocyclic skeleton, while oxeatamide J (5) has an N-methyl urea group included in a γ-lactam moiety. UPLC-QTOF analysis of the extract obtained from the mantle of the nudibranch Felimida grahami indicated the presence of 1 and 4...
February 13, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28169277/investigation-of-the-role-of-tyrosine-kinase-receptor-epha3-in-colorectal-cancer
#6
Elena Andretta, Fernando Cartón-García, Águeda Martínez-Barriocanal, Priscila Guimarães de Marcondes, Lizbeth M Jimenez-Flores, Irati Macaya, Sarah Bazzocco, Josipa Bilic, Paulo Rodrigues, Rocio Nieto, Stefania Landolfi, Santiago Ramon Y Cajal, Simo Schwartz, Arthur Brown, Higinio Dopeso, Diego Arango
EPH signaling deregulation has been shown to be important for colorectal carcinogenesis and genome-wide sequencing efforts have identified EPHA3 as one of the most frequently mutated genes in these tumors. However, the role of EPHA3 in colorectal cancer has not been thoroughly investigated. We show here that ectopic expression of wild type EPHA3 in colon cancer cells did not affect their growth, motility/invasion or metastatic potential in vivo. Moreover, overexpression of mutant EPHA3 or deletion of the endogenous mutant EPHA3 in colon cancer cells did not affect their growth or motility...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28169167/design-and-synthesis-of-a-novel-series-of-4-heteroarylamino-1-azaspiro-oxazole-5-3-bicyclo-2-2-2-octanes-as-%C3%AE-7-nicotinic-receptor-agonists-2-development-of-4-heteroaryl-sar
#7
Christiana Iwuagwu, Dalton King, Ivar M McDonald, James Cook, F Christopher Zusi, Matthew D Hill, Robert A Mate, Haiquan Fang, Ronald Knox, Lizbeth Gallagher, Debra Post-Munson Amy Easton, Regina Miller, Yulia Benitex, Judy Siuciak, Nicholas Lodge, Robert Zaczek, Daniel Morgan, Linda Bristow, John E Macor, Richard E Olson
Quinuclidine-containing spirooxazolines, as described in the previous report in this series, were demonstrated to have utility as α7 nicotinic acetylcholine receptor (α7 nAChR) partial agonists. In this work, the SAR of this chemotype was expanded to include an array of diazine heterocyclic substitutions. Many of the heterocyclic analogs were potent partial agonists of the α7 receptor, selective against other nicotinic receptors and the serotinergic 5HT3A receptor. (1'S,3'R,4'S)-N-(6-phenylpyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2...
January 20, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28138419/paramyxovirus-glycoproteins-and-the-membrane-fusion-process
#8
Hector C Aguilar, Bryce A Henderson, J Lizbeth Zamora, Gunner P Johnston
The family Paramyxoviridae includes many viruses that significantly affect human and animal health. An essential step in the paramyxovirus life cycle is viral entry into host cells, mediated by virus-cell membrane fusion. Upon viral entry, infection results in expression of the paramyxoviral glycoproteins on the infected cell surface. This can lead to cell-cell fusion (syncytia formation), often linked to pathogenesis. Thus membrane fusion is essential for both viral entry and cell-cell fusion and an attractive target for therapeutic development...
September 2016: Current Clinical Microbiology Reports
https://www.readbyqxmd.com/read/28128805/-the-age-and-sex-frequencies-of-patients-with-leukemia-seen-in-two-reference-centers-in-the-metropolitan-area-of-mexico-city
#9
Adrián Santoyo-Sánchez, Christian Omar Ramos-Peñafiel, Azucena Saavedra-González, Lizbeth González-Almanza, Adolfo Martínez-Tovar, Irma Olarte-Carrillo, Juan Collazo-Jaloma
INTRODUCTION: In developing countries, there is commonly a lack of population-based cancer registries or underreporting, thus not recognizing the true dimensions of the problem. AIM: To describe the age and sex frequencies of the major subtypes of leukemias in two hospitals of reference in the metropolitan area of Mexico City. MATERIAL AND METHODS: This is a descriptive and retrospective study, based on medical records of two hematology services during January 2007 to October 2014; all cases diagnosed with leukemia were included...
January 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28117482/recalibration-of-the-klales-et-al-2012-method-of-sexing-the-human-innominate-for-mexican-populations
#10
Jorge A Gómez-Valdés, Antinea Menéndez Garmendia, Lizbeth García-Barzola, Gabriela Sánchez-Mejorada, Carlos Karam, José Pablo Baraybar, Alexandra Klales
OBJECTIVES: The aim of this study was to test the accuracy of the Klales et al. (2012) equation for sex estimation in contemporary Mexican population. MATERIALS AND METHODS: Our investigation was carried out on a sample of 203 left innominates of identified adult skeletons from the UNAM-Collection and the Santa María Xigui Cemetery, in Central Mexico. The Klales' original equation produces a sex bias in sex estimation against males (86-92% accuracy versus 100% accuracy in females)...
March 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28092244/-depression-and-burden-on-primary-caregivers-of-elderly-persons-with-physical-dependence-of-the-umf-171
#11
Cristina Navarro-Sandoval, Lizbeth Carlota Uriostegui-Espíritu, Edna Gabriela Delgado-Quiñones, Minerva Natalia Sahagún-Cuevas
BACKGROUND: According to the National Health and Nutrition Survey of 2012, more than a quarter of older adults (26.9%) have some degree of disability, requiring a primary caregiver to perform basic activities of daily living. The aim is to determine the prevalence of depression and burden on primary caregivers of elderly persons with physical dependence. METHODS: A descriptive cross-sectional study with non-probability sampling that included the primary caregivers of elderly patients with physical dependence...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28073097/moringa-oleifera-a-species-with-potential-analgesic-and-anti-inflammatory-activities
#12
Claudia Lizbeth Martínez-González, Laura Martínez, Efraín J Martínez-Ortiz, María Eva González-Trujano, Myrna Déciga-Campos, Rosa Ventura-Martínez, Irene Díaz-Reval
Moringa oleifera has long been used in large demand in folk medicine to treat pain. The present study was undertaken to examine the antinociceptive and anti-inflammatory spectrum of M. oleifera leaf extracts discriminating the constituents' nature by using different kind of experimental models in rats. Pharmacological evaluation of a non-polar and/or polar extracts at several doses (30-300mg/kg, p.o.) was explored through experimental nociception using formalin test, carrageenan-induced paw edema and arthritis with subcutaneous injection of collagen in rats...
January 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28032670/prospective-study-of-definitive-chemoradiation-in-locally-or-regionally-advanced-squamous-cell-carcinoma-of-the-skin
#13
Michelle K Nottage, Charles Lin, Brett G M Hughes, Lizbeth Kenny, David D Smith, Kathleen Houston, Alessandra Francesconi
BACKGROUND: The purpose of this study was to present our evaluation of the outcomes of concurrent chemoradiotherapy (CRT) in patients with locally advanced cutaneous squamous cell carcinoma (SCC). METHODS: This was a prospective phase II study. The primary endpoint was complete response (CR). Patients with locally/regionally advanced cutaneous SCC deemed unsuitable for surgery received definitive radiotherapy (RT; 70 Gy in 35fractions) and concurrent weekly platinum-based chemotherapy (cisplatin 40 mg/m2 or carboplatin area under the curve 2)...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28024718/patterns-of-dysphagia-and-acute-toxicities-in-patients-with-head-and-neck-cancer-undergoing-helical-imrt%C3%A2-concurrent-chemotherapy
#14
Laura B Moroney, Jennifer Helios, Elizabeth C Ward, Jane Crombie, Leesa F Wockner, Clare L Burns, Ann-Louise Spurgin, Claire Blake, Lizbeth Kenny, Brett G M Hughes
BACKGROUND: There is limited prospective data reporting the extent of treatment related toxicities associated with helical Intensity Modulated Radiotherapy (H-IMRT) for head and neck cancer (HNC). The study aim was to investigate severity, peak incidence and recovery patterns of dysphagia and related toxicities in patients undergoing H-IMRT±chemotherapy to examine when patients are experiencing symptoms requiring supportive clinical care. METHODS: Prospective study of 212 patients undergoing H-IMRT...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28018365/cassava-breeding-ii-phenotypic-correlations-through-the-different-stages-of-selection
#15
Orlando Joaqui Barandica, Juan C Pérez, Jorge I Lenis, Fernando Calle, Nelson Morante, Lizbeth Pino, Clair H Hershey, Hernán Ceballos
Breeding cassava relies on a phenotypic recurrent selection that takes advantage of the vegetative propagation of this crop. Successive stages of selection (single row trial-SRT; preliminary yield trial-PYT; advanced yield trial-AYT; and uniform yield trials UYT), gradually reduce the number of genotypes as the plot size, number of replications and locations increase. An important feature of this scheme is that, because of the clonal, reproduction of cassava, the same identical genotypes are evaluated throughout these four successive stages of selection...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27998541/-incidence-of-hip-and-knee-prosthetic-infections-in-a-specialized-center-of-mexico-city
#16
Rafael Franco-Cendejas, Erika Lizbeth Contreras-Córdova, Jaime Arturo Mondragón-Eguiluz, Edgar Samuel Vanegas-Rodríguez, Víctor Manuel Ilizaliturri-Sánchez, Arturo Galindo-Fraga
BACKGROUND: Hip and knee prosthetic replacements have proven to be the most appropriate treatment in the joints that do not benefit from medical or arthroscopic interventions; however, infections are the most feared complication. It is recommended that the incidence of infection should not exceed 2%. MATERIAL AND METHODS: This was an observational, prospective, longitudinal and observational study conducted in patients fitted with a prosthetic joint from August 2011 to July 2012...
December 17, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27994742/development-of-1h-pyrazolo-3-4-b-pyridines-as-metabotropic-glutamate-receptor-5-positive-allosteric-modulators
#17
Matthew D Hill, Haiquan Fang, Jeffrey M Brown, Thaddeus Molski, Amy Easton, Xiaojun Han, Regina Miller, Melissa Hill-Drzewi, Lizbeth Gallagher, Michele Matchett, Michael Gulianello, Anand Balakrishnan, Robert L Bertekap, Kenneth S Santone, Valerie J Whiterock, Xiaoliang Zhuo, Joanne J Bronson, John E Macor, Andrew P Degnan
The metabotropic glutamate receptor 5 (mGluR5) is an attractive target for the treatment of schizophrenia due to its role in regulating glutamatergic signaling in association with the N-methyl-d-aspartate receptor (NMDAR). We describe the synthesis of 1H-pyrazolo[3,4-b]pyridines and their utility as mGluR5 positive allosteric modulators (PAMs) without inherent agonist activity. A facile and convergent synthetic route provided access to a structurally diverse set of analogues that contain neither the aryl-acetylene-aryl nor aryl-methyleneoxy-aryl elements, the predominant structural motifs described in the literature...
December 8, 2016: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27993517/development-of-spiroguanidine-derived-%C3%AE-7-neuronal-nicotinic-receptor-partial-agonists
#18
Matthew D Hill, Haiquan Fang, Sivarao V Digavalli, Francine L Healy, Lizbeth Gallagher, Debra Post-Munson, Ping Chen, Joanne Natale, Yulia Benitex, Daniel Morgan, Nicholas Lodge, Linda Bristow, John E Macor, Richard E Olson
We describe the synthesis of quinuclidine-containing spiroguanidines and their utility as α7 neuronal nicotinic acetylcholine receptor (nAChR) partial agonists. The convergent synthetic route developed for this study allowed for rapid SAR investigation and provided access to a structurally diverse set of analogs. A potent and selective α7 nAChR partial agonist, N-(6-methyl-1,3-benzoxazol-2-yl)-3',5'-dihydro-4-azaspiro[bicyclo[2.2.2]octane-2,4'-imidazole]-2'-amine (BMS-910731, 16), was identified. This compound induced immediate early genes c-fos and Arc in a preclinical rodent model of α7 nAChR-derived cellular activation and plasticity...
December 7, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27986517/comparison-of-nutritional-and-clinical-outcomes-in-patients-with-head-and-neck-cancer-undergoing-chemoradiotherapy-utilizing-prophylactic-versus-reactive-nutrition-support-approaches
#19
Teresa E Brown, Merrilyn D Banks, Brett G M Hughes, Charles Y Lin, Lizbeth M Kenny, Judith D Bauer
BACKGROUND: The optimal method of tube feeding for patients with head and neck cancer remains unclear. A validated protocol is available that identifies high-nutritional-risk patients who would benefit from prophylactic gastrostomy tube placement. Adherence to this protocol is ultimately determined by clinical team discretion or patient decision. OBJECTIVE: The study aim was to compare outcomes after adherence and nonadherence to this validated protocol, thus comparing a prophylactic and reactive approach to nutrition support in this patient population...
December 13, 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27958732/design-and-synthesis-of-a-new-series-of-4-heteroarylamino-1-azaspiro-oxazole-5-3-bicyclo-2-2-2-octanes-as-%C3%AE-7-nicotinic-receptor-agonists-1-development-of-pharmacophore-and-early-structure-activity-relationship
#20
James Cook, F Christopher Zusi, Ivar M McDonald, Dalton King, Matthew D Hill, Christiana Iwuagwu, Robert A Mate, Haiquan Fang, Rulin Zhao, Bei Wang, Jingfang Cutrone, Baoqing Ma, Qi Gao, Ronald J Knox, Michele Matchett, Lizbeth Gallagher, Meredith Ferrante, Debra Post-Munson, Thaddeus Molski, Amy Easton, Regina Miller, Kelli Jones, Siva Digavalli, Francine Healy, Kimberley Lentz, Yulia Benitex, Wendy Clarke, Joanne Natale, Judith A Siuciak, Nicholas Lodge, Robert Zaczek, Rex Denton, Daniel Morgan, Linda J Bristow, John E Macor, Richard E Olson
The design and synthesis of a series of quinuclidine-containing spirooxazolidines ("spiroimidates") and their utility as α7 nicotinic acetylcholine receptor partial agonists are described. Selected members of the series demonstrated excellent selectivity for α7 over the highly homologous 5-HT3A receptor. Modification of the N-spiroimidate heterocycle substituent led to (1S,2R,4S)-N-isoquinolin-3-yl)-4'H-4-azaspiro[bicyclo[2.2.2]octane-2,5'oxazol]-2'-amine (BMS-902483), a potent α7 partial agonist, which improved cognition in preclinical rodent models...
December 22, 2016: Journal of Medicinal Chemistry
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