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Robert D Gibbons, Margarita Alegría, Li Cai, Lizbeth Herrera, Sheri Lapatin Markle, Francisco Collazos, Enrique Baca-García
We examined cultural differences in the item characteristic functions of self-reported of symptoms of depression, anxiety, and mania-hypomania in a Latino population taking Computerized Adaptive Tests for Mental Health (CAT-MH) in Spanish versus a non-Latino sample taking the tests in English. We studied differential item functioning (DIF) of the most common adaptively administered symptom items out of a bank of 1,008 items between Latino (n = 1276) and non-Latino (n = 798) subjects. For depression, we identified 4 items with DIF that were good discriminators for non-Latinos but poor discriminators for Latinos...
May 24, 2018: Psychological Assessment
Maria Diaz, Udo Wegmann, Nwanneka Akinyemi, Folarin A Oguntoyinbo, Lizbeth Sayavedra, Melinda J Mayer, Arjan Narbad
Ochrobactrum haematophilum FI11154 was isolated from kunu-zaki, a Nigerian traditional fermented millet-based food. Here, we present the first complete genome sequence of this species. The genome consists of five replicons and contains genes related to iron uptake and phosphatase activities.
May 17, 2018: Genome Announcements
Laura B Moroney, Jennifer Helios, Elizabeth C Ward, Jane Crombie, Anita Pelecanos, Clare L Burns, Ann-Louise Spurgin, Claire Blake, Lizbeth Kenny, Benjamin Chua, Brett G M Hughes
BACKGROUND: Conformal radiotherapy modalities may minimize treatment toxicities. The purpose of this study was to document the extent and timing of dysphagia and related toxicities during helical intensity-modulated radiotherapy (IMRT) with chemotherapy for oropharyngeal squamous cell carcinoma (SCC). METHODS: We conducted a prospective study of 76 patients with oropharyngeal SCC undergoing helical IMRT with chemotherapy. Dysphagia and acute toxicity data were collected weekly during treatment and at 2, 4, and 12 weeks posttreatment using the Functional Oral Intake Scale, diet descriptors, and Common Terminology Criteria for Adverse Events (CTCAE) version 4...
May 13, 2018: Head & Neck
Lizbeth Tolentino-Mayo, Sofía Rincón-Gallardo Patiño, Liliana Bahena-Espina, Víctor Ríos, Simón Barquera
OBJECTIVE: To keep record of the knowledge and use of information of the different food labels on industrialized products in Mexico. MATERIALS AND METHODS: We administered a semi-structured survey-developed by research¬ers free of conflict interestin a subsample of the National Health and Nutrition Survey, 2016. This survey was previously validated and piloted in different populations of varying socio¬economic levels and age and country regions. RESULTS: Data was collected from a total of 8 667 individuals ≥20 years of age...
May 2018: Salud Pública de México
Shibin Chacko, Helena I M Boshoff, Vinayak Singh, Davide M Ferraris, Deviprasad R Gollapalli, Minjia Zhang, Ann P Lawson, Michael J Pepi, Andrzej Joachimiak, Menico Rizzi, Valerie Mizrahi, Gregory D Cuny, Lizbeth Hedstrom
New drugs and molecular targets are urgently needed to address the emergence and spread of drug-resistant tuberculosis. Mycobacterium tuberculosis (Mtb) inosine 5'-monophosphate dehydrogenase 2 (MtbIMPDH2) is a promising yet controversial potential target. Inhibition of MtbIMPDH2 blocks the biosynthesis of guanine nucleotides, but high concentrations of guanine can potentially rescue the bacteria. Herein we describe an expansion of the structure-activity relationship (SAR) for the benzoxazole series of MtbIMPDH2 inhibitors and demonstrate that minimum inhibitory concentrations (MIC) of ≤ 1 μM can be achieved...
May 10, 2018: Journal of Medicinal Chemistry
Lizbeth López-Bolaños, Marisol Campos-Rivera, María Ángeles Villanueva-Borbolla
OBJECTIVE: Objective. To reflect on the process of committing to participation in the implementation of a health strategic plan, using Participative Systematization of Social Experiences as a tool. MATERIAL AND METHODS: Our study was a qualitative research-intervention study, based on the Dialectical Methodological Conception approach. We designed and implemented a two-day workshop, six hours daily, using Systematization methodology with a Community Work Group (CWG)...
March 2018: Salud Pública de México
Mey Ling Reytor González, Maday Alonso-Del-Rivero Antigua, Lizbeth Hedstrom, Petr Kuzmič, José Ricardo Pires
Multi-domain inhibitors capable to block the activity of different classes of proteases are not very common in nature. However, these kinds of molecules are attractive systems for biomedical or biotechnological applications, where two or more different targets need to be neutralized. SmCI, the Sabellastarte magnifica Carboxypeptidase Inhibitor, is a tri-domain BPTI-Kunitz inhibitor capable to inhibit serine proteases and A-like metallocarboxypeptidases. The BPTI-Kunitz family of proteins includes voltage gated channel blockers and inhibitors of serine proteases...
May 3, 2018: Biochimie
Gustavo Arnaud-Franco, Amaury Cordero-Tapia, Víctor Ortíz-Ávila, Claudia Lizbeth Moctezuma-González, Moisés Tejocote-Pérez, Alejandro Carbajal-Saucedo
In Mexico more than 40% of reported snakebites are due to rattlesnake species. In general, the venoms of these snakes are characterized by the presence of highly enzymatic components that could provoke coagulopathies, local and systemic tissue damage and some cases neurotoxicity. In northwestern Mexico (Baja California Peninsula, Gulf of California and Pacific islands), 15 species of Crotalus are distributed. Such a biodiversity implies a high variability in venom compositions that in turns would results in high variability in clinical manifestations...
May 3, 2018: Toxicon: Official Journal of the International Society on Toxinology
Lizbeth Martínez-Acevedo, María de la Luz Zambrano-Zaragoza, Gustavo Vidal-Romero, Susana Mendoza-Elvira, David Quintanar-Guerrero
The aim of this study was to develop solid lipid nanoparticles (SLN) and introduce them into a direct compression process to evaluate their lubricant properties. The study consisted of preparing glyceryl behenate SLN (Compritol® 888 ATO) by hot dispersion, and magnesium stearate SLN by a novel nanoprecipitation/ion exchange method. The ejection force was measured for nanosystems and raw materials in a formulation typically used for direct compression. The smallest particle sizes obtained were 456 nm for Compritol® 888 ATO and 330 nm for magnesium stearate...
May 2, 2018: International Journal of Pharmaceutics
Eva M Ramírez, Omar Espinosa, Ricardo Berrones, Elisa M Sepúlveda, Lizbeth Guilbert, Miguel Solís, Carlos Zerrweck
BACKGROUND: Whether or not the initial body mass index (BMI) influences weight loss and comorbidities improvement after bariatric surgery continues to be a matter of debate. The main reason for this is a lack of studies including obesity class I. METHODS: Retrospective study with patients submitted to gastric bypass at a single institution. They were classified based on initial BMI (obesity class I, II, and III), and a comparative analysis of their metabolic profile (glucose, HbA1c%, C-peptide, insulin and diabetes medication), lipid profile (triglycerides, total cholesterol, HDL, LDL), and clinical data (systolic/diastolic blood pressure and cardiovascular risk) was performed at 0 and 12 months...
May 3, 2018: Obesity Surgery
Claudia Hernández-Martínez, Mara Noemí Guzmán-Martínez, Selma Scheffler-Mendoza, Sara Elva Espinosa-Padilla, Cristina Sobacchi, Lizbeth Blancas-Galicia
BACKGROUND: Osteopetrosis is a heterogeneous group of diseases that are characterized by increased bone density due to abnormalities in osteoclast differentiation or function, which result in a lack of bone resorption. CASE REPORTS: Two patients with osteopetrosis onset since the first months of life, with facial dysmorphia, blindness, deafness, hepatosplenomegaly, hypotonia, neurodevelopmental retardation and bicytopenia. Bone radiographs showed osteosclerosis...
January 2018: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
Ruben Ramos, Diego H Caceres, Marilyn Perez, Nicole Garcia, Wendy Castillo, Erika Santiago, Jovanna Borace, Shawn R Lockhart, Elizabeth L Berkow, Lizbeth Hayer, Andres Espinosa-Bode, Jose Moreno, Brendan R Jackson, Jackeline Moran, Tom Chiller, Gloriela de Villarreal, Nestor Sosa, Snigdha Vallabhaneni
Candida duobushaemulonii , a yeast closely related to Candida auris, is thought to rarely cause infections, and is often misidentified. In October 2016, the Panamanian Ministry of Health implemented laboratory surveillance for C. auris Suspected C. auris isolates were forwarded to the national reference laboratory for identification by Matrix Assisted Laser Desorption Ionization-Time of Flight mass spectrometry and antifungal susceptibility testing. During November 2016-May 2017, 17 of 36 (47%) isolates suspected to be C...
April 25, 2018: Journal of Clinical Microbiology
Grace Lartey, Lizbeth P Sturgeon, Dawn Garrett-Wright, Umar Y Kabir, Susan Eagle
Complementary, alternative, and integrative therapies (CAIs) involve the use of practices outside of mainstream, conventional medicine. Few studies have been conducted on nurses' perception and knowledge of CAI therapies. There is limited information on the protocols school nurses must follow in their practice on CAI use. The purpose of this study is to assess school nurses' perception and knowledge of CAI therapies. A cross-sectional, nonexperimental survey study design was used, and participants were sampled with a cross-sectional convenience method...
January 1, 2018: Journal of School Nursing: the Official Publication of the National Association of School Nurses
Rafael Ogaz-González, Ángel Mérida-Ortega, Luisa Torres-Sánchez, Lourdes Schnaas, César Hernández-Alcaraz, Mariano E Cebrián, Stephen J Rothenberg, Rosa María García-Hernández, Lizbeth López-Carrillo
BACKGROUND: Maternal 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) serum levels during pregnancy have been negatively linked to child neurodevelopment in contrast to intake of omega-3 and -6 (ω-3 and ω-6) fatty acids. OBJECTIVES: To assess whether maternal dietary intake of ω-3 and ω-6 during pregnancy modifies the association between exposure to DDE and child neurodevelopment from age 42-60 months. METHODS: Prospective cohort study with 142 mother-child pairs performed in Mexico...
April 2, 2018: Environmental Pollution
Iris E Martínez-Juárez, Bianca Funes, Julio C Moreno-Castellanos, Elisa Bribiesca-Contreras, Verónica Martínez-Bustos, Lizeth Zertuche-Ortuño, Laura E Hernández-Vanegas, Lizbeth Hernandez Ronquillo, Syed Rizvi, Wu Adam, Jose F Tellez-Zenteno
Objective: To provide a comprehensive transnational overview of wait times for epilepsy surgery in Canada and Mexico. Methods: We reviewed all cases referred for epilepsy surgery between 2007 and 2015 at the Saskatchewan Epilepsy Program Royal University Hospital (SEP) (n = 70; Saskatoon, Canada) and the National Institute of Neurology and Neurosurgery (NINN) (n = 76; Mexico City, Mexico) and compared wait times, calculated as the time from diagnosis of epilepsy on assessment at an epilepsy center to epilepsy surgery...
December 2017: Epilepsia Open
Edgar Denova-Gutiérrez, Paloma Muñoz-Aguirre, Nitin Shivappa, James R Hébert, Lizbeth Tolentino-Mayo, Carolina Batis, Simón Barquera
Diet and inflammation are both associated with type 2 diabetes mellitus (T2DM). In the present study, we aimed to assess the relation between the dietary inflammatory index (DII) and the presence of T2DM in Mexican adults participating in the Diabetes Mellitus Survey administered in Mexico City (DMS-MC). The study involved 1174 subjects (48.5% men) between 20-69 years of age. A validated semi-quantitative food frequency questionnaire was employed to evaluate dietary intake and to compute DII. The DII is based on scientific evidence about the association between dietary compounds and six established inflammatory biomarkers...
March 21, 2018: Nutrients
Masha M Rosenberg, Alfred G Redfield, Mary F Roberts, Lizbeth Hedstrom
The ability of enzymes to modulate the dynamics of bound substrates and cofactors is a critical feature of catalysis, but the role of dynamics has largely been approached from the perspective of the protein. Here, we use an underappreciated NMR technique, subtesla high-resolution field-cycling 31 P NMR relaxometry, to interrogate the dynamics of enzyme bound substrates and cofactors in guanosine-5'-monophosphate reductase (GMPR). These experiments reveal distinct binding modes and dynamic profiles associated with the 31 P nuclei in the Michaelis complexes for the deamination and hydride transfer steps of the catalytic cycle...
March 26, 2018: Biochemistry
Oscar Illescas, Juan C Gomez-Verjan, Lizbeth García-Velázquez, Tzipe Govezensky, Miriam Rodriguez-Sosa
Human macrophage migration inhibitory factor (MIF) is a cytokine that plays a role in several metabolic and inflammatory processes. Single nucleotide polymorphism (SNP) -173 G/C (rs755622) on MIF gene has been associated with numerous diseases, such as arthritis and cancer. However, most of the reports concerning the association of MIF with these and other pathologies are inconsistent and remain quite controversial. Therefore, we performed a meta-analysis from 96 case-control studies on -173 G/C MIF SNP and stratified the data according to the subjects geographic localization or the disease pathophysiology, in order to determine a more meaningful significance to this SNP...
2018: Frontiers in Genetics
Sandro Virgilio Porceddu, Mathias Bressel, Michael Geoffrey Poulsen, Adam Stoneley, Michael John Veness, Lizbeth Moira Kenny, Chris Wratten, June Corry, Stephen Cooper, Gerald Blaise Fogarty, Marnie Collins, Michael Kevin Collins, Andrew Martin John Macann, Christopher Gerard Milross, Michael Gordon Penniment, Howard Yu-Hao Liu, Madeleine Trudy King, Benedict James Panizza, Danny Rischin
Purpose To report the results of the Trans Tasman Radiation Oncology Group randomized phase III trial designed to determine whether the addition of concurrent chemotherapy to postoperative radiotherapy (CRT) improved locoregional control in patients with high-risk cutaneous squamous cell carcinoma of the head and neck. Patients and Methods The primary objective was to determine whether there was a difference in freedom from locoregional relapse (FFLRR) between 60 or 66 Gy (6 to 6.5 weeks) with or without weekly carboplatin (area under the curve 2) after resection of gross disease...
May 1, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Jane S Richardson, Christopher J Williams, Bradley J Hintze, Vincent B Chen, Michael G Prisant, Lizbeth L Videau, David C Richardson
Traditionally, validation was considered to be a final gatekeeping function, but refinement is smoother and results are better if model validation actively guides corrections throughout structure solution. This shifts emphasis from global to local measures: primarily geometry, conformations and sterics. A fit into the wrong local minimum conformation usually produces outliers in multiple measures. Moving to the right local minimum should be prioritized, rather than small shifts across arbitrary borderlines...
February 1, 2018: Acta Crystallographica. Section D, Structural Biology
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