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https://www.readbyqxmd.com/read/29154747/disseminated-methicillin-susceptible-staphylococcus-aureus-infection
#1
David R Perkins, James A Hall, Lisa M Lopez, Lizbeth Janice Cahuayme-Zuniga
INTRODUCTION: When clinicians think about Staphylococcus aureus bacteria, what comes to the mind of most is the dreaded methicillin-resistant form. However, clinicians should not forget the methicillin-susceptible type, which is just as virulent. CASE PRESENTATION: The authors present the case of a 20-year-old woman who was admitted with septic shock and multi-organ failure and was found to have disseminated methicillin-susceptible Staphylococcus aureus (MSSA) infection...
November 20, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29097064/acanthamoeba-t4-trophozoites-cross-the-mdck-epithelium-without-cell-damage-but-increase-paracellular-permeability-and-transepithelial-resistance-by-modifying-tight-junction-composition
#2
Catalina Flores-Maldonado, Arturo González-Robles, Lizbeth Salazar-Villatoro, Maritza Omaña-Molina, Juan Manuel Gallardo, Mónica González-Lázaro, Verónica Ivonne Hernández-Ramírez, Patricia Talamás-Rohana, Jacob Lorenzo-Morales, Adolfo Martínez-Palomo
Free-living amoebae of the genus Acanthamoeba are protozoa ubiquitously found in nature. Some species of the genus are potentially pathogenic for humans provoking keratitis in healthy individuals, often in contact lens wearers and opportunistic infections such as pneumonitis, fatal granulomatous encephalitis and skin infections, particularly in immunocompromised individuals. The pathogenic mechanisms of these amoebae are poorly understood, however it had been suggested that contact dependent mechanisms are important during invasion, regardless of the epithelia type, since amoebae penetrate epithelia separating tight junction (TJ)...
October 31, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/29081270/home-based-telehealth-service-for-swallowing-and-nutrition-management-following-head-and-neck-cancer-treatment
#3
Annette Collins, Clare L Burns, Elizabeth C Ward, Tracy Comans, Claire Blake, Lizbeth Kenny, Phil Greenup, Daniel Best
Introduction Following (chemo)radiotherapy (C/RT) for head and neck cancer (HNC), patients return to hospital for regular outpatient reviews with speech pathology (SP) and nutrition and dietetics (ND) for acute symptom monitoring, nutritional management, and swallowing and communication rehabilitation. The aim of the current study was to determine the feasibility of a home-based telehealth model for delivering SP and ND reviews, to provide patients with more convenient access to these appointments. Methods Service outcomes, costs, and consumer satisfaction were examined across 30 matched participants: 15 supported via the standard model of care (SMOC), and 15 via the home-based telehealth model of care (TMOC)...
December 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29067766/molprobity-more-and-better-reference-data-for-improved-all-atom-structure-validation
#4
Christopher J Williams, Jeffrey J Headd, Nigel W Moriarty, Michael G Prisant, Lizbeth L Videau, Lindsay N Deis, Vishal Verma, Daniel A Keedy, Bradley J Hintze, Vincent B Chen, Swati Jain, Steven M Lewis, W Bryan Arendall, Jack Snoeyink, Paul D Adams, Simon C Lovell, Jane S Richardson, David C Richardson
This paper describes the current update on macromolecular model validation services that are provided at the MolProbity website, emphasizing changes and additions since the previous review in 2010. There have been many infrastructure improvements, including rewrite of previous Java utilities to now use existing or newly written Python utilities in the open-source CCTBX portion of the Phenix software system. This improves long-term maintainability and enhances the thorough integration of MolProbity-style validation within Phenix...
October 25, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29063444/fast-inactivation-of-cav2-2-channels-is-prevented-by-the-g%C3%AE-1-subunit-in-rat-sympathetic-neurons
#5
Arturo Reyes-Vaca, Lizbeth de la Cruz, Julieta Garduño, Isabel Arenas, David E Garcia
Voltage-dependent regulation of CaV2.2 channels by G-proteins is performed by the β (Gβ) subunit. Most studies of regulation by G-proteins have focused on channel activation; however, little is known regarding channel inactivation. This study investigated inactivation of CaV2.2 channels in superior cervical ganglion neurons that overexpressed Gβ subunits. CaV2.2 currents were recorded by whole-cell patch clamping configuration. We found that the Gβ1 subunit reduced inactivation, while Gβ5 subunit did not alter at all inactivation kinetics compared to control recordings...
October 23, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29050936/t%C3%AE-riii-is-induced-by-tcr-signaling-and-downregulated-in-foxp3-regulatory-t-cells
#6
Sandra Ortega-Francisco, Marisol de la Fuente-Granada, Evelyn K Alvarez Salazar, Lizbeth Airais Bolaños-Castro, Gabriela Fonseca-Camarillo, Roxana Olguin-Alor, Germán R Alemán-Muench, Fernando López-Casillas, Chander Raman, Eduardo A García-Zepeda, Gloria Soldevila
TGF-β type III receptor (TβRIII) is a co-receptor for TGFβ family members required for high-affinity binding of these ligands to their receptors, potentiating their cellular functions. TGF-βs, Bone Morphogenetic Proteins (BMP2/4) and Inhibins/Activins regulate different checkpoints during T cell differentiation. We have previously reported that TβRIII modulates T cell development by protecting developing thymocytes from apoptosis, however the role of this co-receptor in peripheral lymphocytes still remains elusive...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29050783/design-and-synthesis-of-a-novel-series-of-1-s-2r-4-s-3h-4-azaspiro-benzo-4-5-imidazo-2-1-b-oxazole-2-2-bicyclo-2-2-2-octanes-with-high-affinity-for-the-%C3%AE-7-neuronal-nicotinic-receptor
#7
James Cook, F Christopher Zusi, Matthew D Hill, Haiquan Fang, Bradley Pearce, Hyunsoo Park, Lizbeth Gallagher, Ivar M McDonald, Linda Bristow, John E Macor, Richard E Olson
We describe an efficient and convergent synthesis of a series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] displaying potency for the α7 nicotinic acetylcholine receptor (nAChR) and good selectivity vs. the related 5-HT3A receptor.
November 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29050703/validity-of-the-edinburgh-claudication-questionnaire-for-diagnosis-of-peripheral-artery-disease-in-patients-with-type-2-diabetes
#8
Salvador Pita-Fernández, María José Modroño-Freire, Sonia Pértega-Díaz, Lizbeth Herrera-Díaz, Teresa Seoane-Pillado, Adriana Paz-Solís, José Luis Varela Modroño
OBJECTIVE: To assess the prevalence of peripheral artery disease and the validity of clinical signs for its diagnosis in patients with type 2 diabetes. METHODS: Setting: Health center (Mariñamansa,Orense). PERIOD: January 2011-January 2013. INCLUSION CRITERIA: Patients with type 2 diabetes, informed consent. MEASUREMENTS: Age, sex, diabetes duration, body mass index, Charlson index, blood pressure, ankle-brachial index (ABI), cholesterol levels, smoking...
November 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/29050495/modeling-the-pressure-inactivation-of-escherichia-coli-and-salmonella-typhimurium-in-sapote-mamey-pouteria-sapota-jacq-h-e-moore-stearn-pulp
#9
Daniela Saucedo-Reyes, José A Carrillo-Salazar, Lizbeth Román-Padilla, Crescenciano Saucedo-Veloz, María I Reyes-Santamaría, Mariana Ramírez-Gilly, Alberto Tecante
High hydrostatic pressure inactivation kinetics of Escherichia coli ATCC 25922 and Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028 ( S. typhimurium) in a low acid mamey pulp at four pressure levels (300, 350, 400, and 450 MPa), different exposure times (0-8 min), and temperature of 25 ± 2℃ were obtained. Survival curves showed deviations from linearity in the form of a tail (upward concavity). The primary models tested were the Weibull model, the modified Gompertz equation, and the biphasic model...
January 1, 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/29043556/incidence-of-atrioventricular-block-with-vasodilator-stress-spect-a-meta-analysis
#10
Efstathia Andrikopoulou, Charity J Morgan, Lizbeth Brice, Navkaranbir S Bajaj, Harish Doppalapudi, Ami E Iskandrian, Fadi G Hage
BACKGROUND: Adenosine or regadenoson are often used with pharmacologic stress testing. Adenosine may trigger atrioventricular block (AVB). Despite its higher selectivity, regadenoson has also been associated with AVB. We studied the incidence of de novo AVB with these agents. METHODS: A comprehensive search of SCOPUS was performed from inception to March 2016. Studies of at least 10 patients, using adenosine and/or regadenoson with SPECT-MPI, reporting rates of AVB were selected for further review...
October 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29023396/diversity-and-antimicrobial-potential-of-predatory-bacteria-from-the-peruvian-coastline
#11
Luis Linares-Otoya, Virginia Linares-Otoya, Lizbeth Armas-Mantilla, Cyntia Blanco-Olano, Max Crüsemann, Mayar L Ganoza-Yupanqui, Julio Campos-Florian, Gabriele M König, Till F Schäberle
The microbiome of three different sites at the Peruvian Pacific coast was analyzed, revealing a lower bacterial biodiversity at Isla Foca than at Paracas and Manglares, with 89 bacterial genera identified, as compared to 195 and 173 genera, respectively. Only 47 of the bacterial genera identified were common to all three sites. In order to obtain promising strains for the putative production of novel antimicrobials, predatory bacteria were isolated from these sampling sites, using two different bait organisms...
October 12, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28986247/the-reintroduction-of-denv-2-in-2011-in-panama-and-subsequent-outbreak-characteristic
#12
Yamilka Díaz, Julio Cisneros, Hilda Guzmán, Paola Cordoba, Jean-Paul Carrera, Brechla Moreno, Rubing Chen, Juan Castillo Mewa, Lourdes García, Lizbeth Cerezo, Amelia Travassos da Rosa, Nathan D Gundacker, Blas Armién, Scott C Weaver, Nikos Vasilakis, Sandra López-Vergès, Robert Tesh
The circulation of the South-east Asian/American (AS/AM) dengue 2 virus (DENV-2) genotype in the Americas has been associated with a high rate of severe disease. From 1993, the year DENV was reintroduced in Panama, until 2011 there were 29 dengue-associated deaths, 17 of which occurred in 2011, the most severe outbreak with a case fatality rate (CFR) of 44% (17 deaths out of 38 severe dengue cases). During this outbreak DENV-2 was reintroduced into the country, whereas over the prior five years DENV-1 and -3 were predominant...
October 3, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28974450/acanthamoeba-culbertsoni-isolated-from-a-clinical-case-with-intraocular-dissemination-structure-and-in%C3%A2-vitro-analysis-of-the-interaction-with-hamster-cornea-and-mdck-epithelial-cell-monolayers
#13
Arturo González-Robles, Maritza Omaña-Molina, Lizbeth Salazar-Villatoro, Catalina Flores-Maldonado, Jacob Lorenzo-Morales, María Reyes-Batlle, Francisco Arnalich-Montiel, Adolfo Martínez-Palomo
Acanthamoeba culbertsoni trophozoites, previously isolated from a human keratitis case with severe intraocular damage, were maintained in axenic culture. Co-incubation of amoebae with MDCK cell monolayers demonstrated an apparent preference of the amoebae to introduce themselves between the cells. The trophozoites appeared to cross the cell monolayer through the tight junctions, which resulted in decreased trans-epithelial resistance (TER) measurements. Unexpectedly, after co-incubation of amoebae with hamster corneas, we observed that the trophozoites were able to cross the different cell layers and reach the corneal stroma after only 12 h of interaction, in contrast to other Acanthamoeba species...
September 30, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28963804/cost-analysis-of-a-speech-pathology-synchronous-telepractice-service-for-patients-with-head-and-neck-cancer
#14
Clare L Burns, Sanjeewa Kularatna, Elizabeth C Ward, Anne J Hill, Joshua Byrnes, Lizbeth M Kenny
BACKGROUND: The purpose of this study is to report the economic outcomes of a new synchronous telepractice service providing speech pathology intervention to patients with head and neck cancer at nonmetropolitan facilities. METHODS: A multisite randomized controlled trial comparing standard care versus a new synchronous telepractice model was conducted within a large Australian public cancer service. Data pertaining to health service costs (staff wages, equipment, and patient travel reimbursement), patient +/- carer costs (travel and wages), and patient-reported quality of life (Assessment of Quality of Life questionnaire 4D) were collected...
September 30, 2017: Head & Neck
https://www.readbyqxmd.com/read/28961176/phytoestrogen-concentrations-in-human-urine-as-biomarkers-for-dietary-phytoestrogen-intake-in-mexican-women
#15
Karina M Chávez-Suárez, María I Ortega-Vélez, Ana I Valenzuela-Quintanar, Marcia Galván-Portillo, Lizbeth López-Carrillo, Julián Esparza-Romero, María S Saucedo-Tamayo, María R Robles-Burgueño, Susana A Palma-Durán, María L Gutiérrez-Coronado, Melissa M Campa-Siqueiros, Patricia Grajeda-Cota, Graciela Caire-Juvera
There has been substantial interest in phytoestrogens, because of their potential effect in reducing cancer and heart disease risk. Measuring concentrations of phytoestrogens in urine is an alternative method for conducting epidemiological studies. Our objective was to evaluate the urinary excretion of phytoestrogens as biomarkers for dietary phytoestrogen intake in Mexican women. Participants were 100 healthy women from 25 to 80 years of age. A food frequency questionnaire (FFQ) and a 24 h recall were used to estimate habitual and recent intakes of isoflavones, lignans, flavonols, coumestrol, resveratrol, naringenin, and luteolin...
September 29, 2017: Nutrients
https://www.readbyqxmd.com/read/28959082/behavioral-landscapes-and-earth-mover-s-distance-a-new-approach-for-studying-individual-differences-in-density-distributions
#16
Nilam Ram, Lizbeth Benson, Timothy R Brick, David E Conroy, Aaron L Pincus
Contemporary views of personality highlight intraindividual variability. We forward a general method for quantifying individual differences in behavioral tendencies based on Earth Mover's Distance. Using data from 150 individuals who reported on their and others' interpersonal behavior in 64,112 social interactions, we illustrate how this new approach can advance notions of personality as density distributions. Results provide independent confirmation and establish validity of existing representations of individual differences in interpersonal behavior, and identify new dimensions and profiles of personality and well-being...
August 2017: Journal of Research in Personality
https://www.readbyqxmd.com/read/28957379/involvement-of-parkin-in-the-ubiquitin-proteasome-system-mediated-degradation-of-n-type-voltage-gated-ca2-channels
#17
Lizbeth Grimaldo, Alejandro Sandoval, Edgar Garza-López, Ricardo Felix
N-type calcium (CaV2.2) channels are widely expressed in the brain and the peripheral nervous system, where they play important roles in the regulation of transmitter release. Although CaV2.2 channel expression levels are precisely regulated, presently little is known regarding the molecules that mediate its synthesis and degradation. Previously, by using a combination of biochemical and functional analyses, we showed that the complex formed by the light chain 1 of the microtubule-associated protein 1B (LC1-MAP1B) and the ubiquitin-proteasome system (UPS) E2 enzyme UBE2L3, may interact with the CaV2...
2017: PloS One
https://www.readbyqxmd.com/read/28950674/biomarkers-in-tumorigenesis-using-cancer-cell-lines-a-systematic-review
#18
Lizbeth Raju K, Dominic Augustine, Roopa S Rao, Sowmya S V, Vanishri C Haragannavar, Shwetha Nambiar, Kavitha Prasad, Kamran Habib Awan, Shankargouda Patil
Cancer is a leading cause of death worldwide. Despite many research advancements in the field, the genetic changes regulating the transformation of normal oral cells into malignant cells have not been fully elucidated. Several studies have evaluated carcinogenesis at the molecular level. Cancer cell lines are commonly used in biomedical research because they provide an unlimited source of cells and represent various stages of initiation and progression of carcinogenesis in vitro. Aims: The objective of the study was to review original research articles using cancer cell lines as a tool to understand carcinogenesis and to identify the genes involved in tumor development...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28945325/isolation-of-candida-auris-from-nine-patients-in-central-america-importance-of-accurate-diagnosis-and-susceptibility-testing
#19
Ana B Araúz, Diego H Caceres, Erika Santiago, Paige Armstrong, Susan Arosemena, Carolina Ramos, Andres Espinosa-Bode, Jovanna Borace, Lizbeth Hayer, Israel Cedeño, Brendan R Jackson, Nestor Sosa, Elizabeth L Berkow, Shawn R Lockhart, Amalia Rodriguez-French, Tom Chiller
Candida auris is an emerging multidrug-resistant (MDR) fungus associated with invasive infections and high mortality. This report describes nine patients from whom C. auris was isolated at a hospital in Panama City, Panama, the first such cases in Central America, and highlights the challenges of accurate identification and methods for susceptibility testing. This article is protected by copyright. All rights reserved.
September 25, 2017: Mycoses
https://www.readbyqxmd.com/read/28943821/continuous-antithrombin-iii-administration-in-pediatric-veno-arterial-extracorporeal-membrane-oxygenation
#20
Kristina M Nelson, Lizbeth A Hansen, Marie E Steiner, Gwenyth A Fischer, John Dehnel, Sameer Gupta
The purpose of this retrospective case-control study is to determine the effect of continuous antithrombin III (ATIII) infusion on extracorporeal membrane oxygenation (ECMO) coagulation. All ECMO patients within the pediatric intensive care unit from January 2012 to July 2014 were included. Comparison was made between those who received continuous infusion ATIII through a standardized replacement protocol with historic controls receiving intermittent ATIII doses. Patients receiving the continuous infusion ATIII protocol spent more time in goal ACT range (71...
July 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
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