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Spasmodic torticollis

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https://www.readbyqxmd.com/read/29670567/gaba-a-receptor-availability-changes-underlie-symptoms-in-isolated-cervical-dystonia
#1
Brian D Berman, Rebecca Tran Pollard, Erika Shelton, Ramesh Karki, Peter M Smith-Jones, Yubin Miao
GABAA receptor availability changes within sensorimotor regions have been reported in some isolated forms of dystonia. Whether similar abnormalities underlie symptoms in cervical dystonia is not known. In the present study, a total of 15 cervical dystonia patients and 15 age- and sex-matched controls underwent 11 C-flumazenil PET/CT scanning. The density of available GABAA receptors was estimated using a Simplified Reference Tissue Model 2. Group differences were evaluated using a two-sample T -test, and correlations with dystonia severity, as measured by the Toronto Western Spasmodic Torticollis Rating Scale, and disease duration were evaluated using a regression analysis...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29608485/new-rhizotomy-procedure-for-primary-spasmodic-torticollis
#2
Chunhui Hua, Benfang Pu, Kaizhang Liu, Zhenyu Huang, Changhua Li, Changyi Zhao, Xinyuan Li
OBJECTIVE: Spasmodic torticollis (ST) is an idiopathic neurologic disorder affecting the muscles of the neck. Surgery is a preferred treatment, when conservative treatments or Botulinum neurotoxin injections fail to relieve the symptoms. Our objective here is to report the outcome of a new surgical method for treating ST patients in our department. METHODS: The new procedure consists of rhizotomy of the spinal accessory nerve (SAN) and C1-C2 nerve roots, coagulation of the distal end of SAN (Group A)...
March 30, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29607887/pilot-study-of-a-device-to-induce-the-hanger-reflex-in-patients-with-cervical-dystonia
#3
Takashi Asahi, Michi Sato, Takuto Nakamura, Yuki Kon, Hiroyuki Kajimoto, Genko Oyama, Akito Hayashi, Kazunori Tanaka, Shunya Nakane, Takao Takeshima, Masami Fujii, Satoshi Kuroda
The hanger reflex (HR) is an involuntary head rotation that occurs in response to a clothes hanger encircling the head and compressing the unilateral fronto-temporal area. Here, we developed an elliptical device to induce the HR and examined its utility for the treatment of cervical dystonia (CD). The study included 19 patients with rotational-type CD. The device was applied to each subject's head for at least 30 min/day for 3 months. Severity scores on part 1 of the Toronto Western Spasmodic Torticollis Rating Scale were evaluated at baseline and after the 3-month trial...
March 31, 2018: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29557988/personalized-botulinum-toxin-type-a-therapy-for-cervical-dystonia-based-on-kinematic-guidance
#4
Olivia Samotus, Jack Lee, Mandar Jog
BACKGROUND: Botulinum toxin type A (BoNT-A) injections is the accepted first-line therapy for cervical dystonia (CD), however, numerous patients discontinue treatment early due to perceived sub-optimal relief. To improve BoNT-A therapy for CD, proper assessment of neck motion and selection of relevant muscles and dosing must be met. Kinematic technology may improve treatment outcomes by guiding physicians to better tailor muscle selection and BoNT-A dosing for CD therapy. METHODS: 28 CD participants were placed into either group: expert injector determined injection patterns by visual assessment ("vb") versus injection patterns based on kinematics interpreted by an expert injector ("kb")...
March 20, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29541052/relationships-between-serotonin-transporter-binding-in-the-raphe-nuclei-basal-ganglia-and-hippocampus-with-clinical-symptoms-in-cervical-dystonia-a-11-c-dasb-positron-emission-tomography-study
#5
Marenka Smit, David Vállez García, Bauke M de Jong, Evelien Zoons, Jan Booij, Rudi A Dierckx, Antoon T Willemsen, Erik F de Vries, Anna L Bartels, Marina A Tijssen
Purpose: Alterations of the central serotonergic system have been implicated in the pathophysiology of dystonia. In this molecular imaging study, we assessed whether altered presynaptic serotonin transporter (SERT) binding contributes to the pathophysiology of cervical dystonia (CD), concerning both motor and non-motor symptoms (NMS). Methods: We assessed the non-displaceable binding potential (BPND ) using the selective SERT tracer [11 C]DASB and positron emission tomography (PET) in 14 CD patients and 12 age- and gender-matched controls...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29530726/minimal-clinically-important-change-in-the-toronto-western-spasmodic-torticollis-rating-scale
#6
Alberto J Espay, Richard Trosch, Gustavo Suarez, Jonathan Johnson, Dominic Marchese, Cynthia Comella
OBJECTIVES: To characterize the minimal clinically important change (MCIC) after treatment in cervical dystonia patients using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). METHODS: Changes in the TWSTRS from an observational study of abobotulinumtoxinA in the routine management of cervical dystonia (NCT01314365) were analyzed using the Patient Global Impression of Change (PGIC) as anchor. RESULTS: For the overall population (N = 304, baseline TWSTRS-Total score 43...
March 7, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29488101/a-simplified-ultrasonography-guided-approach-for-neurotoxin-injection-into-the-obliquus-capitis-inferior-muscle-in-spasmodic-torticollis
#7
Uwe Walter, Ales Dudesek, Urban M Fietzek
The obliquus capitis inferior (OCI) muscle may be crucially involved in generating the tremulous component of spasmodic torticollis. This study was undertaken to evaluate the efficacy of a simplified ultrasonography-guided approach of botulinum neurotoxin injection into the OCI in the management of spasmodic torticollis. Here, a novel off-plane technique of ultrasonography-guided botulinum neurotoxin injection into the OCI is demonstrated on video. We investigated its effect in five patients with tremulous torticollis with only partial response to conventional injection technique not injecting OCI...
February 27, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29343142/a-500-u-2-ml-dilution-of-abobotulinumtoxina-vs-placebo-randomized-study-in-cervical-dystonia
#8
Mark F Lew, Allison Brashear, Khashayar Dashtipour, Stuart Isaacson, Robert A Hauser, Pascal Maisonobe, Daniel Snyder, William Ondo
Purpose/aim: AbobotulinumtoxinA (Dysport®, Ipsen Biopharmaceuticals, Inc., Basking Ridge, NJ, USA) is an acetylcholine release inhibitor and a neuromuscular blocking agent. The United States prescribing information for abobotulinumtoxinA previously indicated only one dilution for cervical dystonia: 500 U/1 mL. Clinical trial data supporting a larger volume with a 500 U/2 mL dilution would offer clinicians flexibility with injection volume to better meet patient needs. MATERIALS AND METHODS: We conducted a 12-week, phase 3b, multicenter, randomized, double-blind, placebo-controlled trial (NCT01753310)...
January 17, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29339087/erratum-to-spasmodic-torticollis-after-orthognathic-surgery-j-stomatol-oral-maxillofac-surg-118-2017-393-6
#9
R Nicot, M Schlund, S Konopnicki, J Ferri
No abstract text is available yet for this article.
February 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29230798/botulinum-toxin-type-a-therapy-for-cervical-dystonia
#10
REVIEW
Mafalda Castelão, Raquel E Marques, Gonçalo S Duarte, Filipe B Rodrigues, Joaquim Ferreira, Cristina Sampaio, Austen P Moore, João Costa
BACKGROUND: This is an update of a Cochrane Review first published in 2005. Cervical dystonia is the most common form of focal dystonia and is a highly disabling movement disorder characterised by involuntary, usually painful, head posturing. Currently, botulinum toxin type A (BtA) is considered the first line therapy for this condition. OBJECTIVES: To compare the efficacy, safety, and tolerability of botulinum toxin type A (BtA) versus placebo in people with cervical dystonia...
December 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29106650/selective-cervical-denervation-for-cervical-dystonia-modification-of-the-bertrand-procedure
#11
Thomas J Wilson, Robert J Spinner
BACKGROUND: Cervical dystonia, commonly referred to as spasmodic torticollis, is a neurological disorder characterized by aberrant, involuntary contraction of the muscles of the neck and shoulders. One surgical option that can be considered is selective cervical denervation. OBJECTIVE: To report our modification of the Bertrand procedure for selective cervical denervation. METHODS: Our modification of the Bertrand procedure for selective cervical denervation is reported with intraoperative photographs and schematic depictions of the operative steps...
July 6, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28961350/motor-cortical-plasticity-relates-to-symptom-severity-and-clinical-benefit-from-deep-brain-stimulation-in-cervical-dystonia
#12
Daniel Kroneberg, Philip Plettig, Gerd-Helge Schneider, Andrea A Kühn
OBJECTIVE: To investigate the relationship between motor cortical plasticity, intracortical inhibition, and clinical response to pallidal deep brain stimulation (DBS) in patients with cervical dystonia (CD). MATERIALS AND METHODS: Response to paired associative stimulation (PAS) and short interval intracortical inhibition (SICI) were assessed in patients with CD before and after three months of DBS and correlated with severity of dystonic symptoms as assessed by Toronto-Western-Spasmodic Torticollis Rating Scale (TWSTRS) severity score...
September 29, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28939542/comparison-of-2-operative-methods-for-treating-laterocollis-and-torticollis-subtypes-of-spasmodic-torticollis-follow-up-of-121-cases
#13
COMPARATIVE STUDY
Xinyuan Li, Shiting Li, Benfang Pu, Chunhui Hua
OBJECTIVE: The aim of this study was to compare the effects and complications of microvascular decompression (MVD) and neurectomy of spinal accessory nerve in the treatment of laterocollis and torticollis subtypes spasmodic torticollis (ST). METHODS: Clinical data were retrospectively collected from 121 patients with laterocollis and torticollis subtypes of ST from January 1, 2012 to January 1, 2016. Among all the patients, 80 were treated by MVD and 41 were treated by neurectomy of spinal accessory nerve...
December 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28920067/a-history-of-dystonia-ancient-to-modern
#14
REVIEW
Rachel E Newby, Deborah E Thorpe, Peter A Kempster, Jane E Alty
Before 1911, when Hermann Oppenheim introduced the term dystonia, this movement disorder lacked a unifying descriptor. While words like epilepsy, apoplexy, and palsy have had their meanings since antiquity, references to dystonia are much harder to identify in historical documents. Torticollis is an exception, although there is difficulty distinguishing dystonic torticollis from congenital muscular torticollis. There are, nevertheless, possible representations of dystonia in literature and visual art from the pre-modern world...
July 2017: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/28838773/spasmodic-torticollis-after-orthognathic-surgery
#15
R Nicot, M Schlund, S Konopnicki, J Ferri
The treatment of malocclusions can involve orthognathic surgery. Although orthognathic surgery is a safe surgical procedure, low incidences of many complications have been reported such as infections, hemorrhage, nerve injuries, temporomandibular disorders (TMDs), and psychological problems. There are no reports in the literature of orthognathic surgery being associated with postural disorders although the link between dental occlusion and postural disorders is highlighted in numerous recent publications. This report describes the case of a young, healthy patient who presented with sustained spasmodic torticollis following orthognathic surgery...
December 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28661018/clinical-characterization-of-dystonia-in-adult-patients-with-huntington-s-disease
#16
N A van de Zande, T H Massey, D McLauchlan, A Pryce Roberts, R Zutt, M Wardle, G C Payne, C Clenaghan, M A J Tijssen, A E Rosser, K J Peall
BACKGROUND AND PURPOSE: Huntington's disease (HD) is an autosomal dominant, neurodegenerative movement disorder, typically characterized by chorea. Dystonia is also recognized as part of the HD motor phenotype, although little work detailing its prevalence, distribution, severity and impact on functional capacity has been published to date. METHODS: Patients (>18 years of age) were recruited from the Cardiff (UK) HD clinic, each undergoing a standardized videotaped clinical examination and series of functional assessment questionnaires (Unified Huntington's Disease Rating Scale, Burke-Fahn-Marsden Dystonia Rating Scale and modified version of the Toronto Western Spasmodic Torticollis Rating Scale)...
June 29, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28578512/infected-colloid-cyst
#17
Atilla Yilmaz, Mustafa Aras, Yurdal Serarslan, Mustafa Emrah Kaya
INTRODUCTION: Colloid cysts are the most common pathologic lesions of the third ventricle. Although they are histologically benign, they may grow and can cause the hydrocephalus. A 5-year-old male patient underwent to surgery with the diagnosis of colloid cyst. In operation, after the anterior transcallosal approach, the cyst was punctured by syringe and obviously pus aspirated. CONCLUSION: Colloid cysts mostly remain silent and detected incidentally. Although it is rarely defined, rhinorrhea, hypopituitarism, diabetes insipidus, spasmodic torticollis, drop attack, aseptic meningitis, and coexistence with neurocysticercosis have been reported, but this is the first reported case of an infected colloid cyst...
September 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28458568/cost-effectiveness-analysis-of-abobotulinumtoxina-for-the-treatment-of-cervical-dystonia-in-the-united-kingdom
#18
Madhusubramanian Muthukumar, Kamal Desai, Seye Abogunrin, Timothy Harrower, Sylvie Gabriel, Jerome Dinet
BACKGROUND: Cervical dystonia (CD) involves painful involuntary contraction of the neck and shoulder muscles and abnormal posture in middle-aged adults. Botulinum neurotoxin type A (BoNT-A) is effective in treating CD but little is known about its associated cost-effectiveness. OBJECTIVE: To evaluate the cost-effectiveness of abobotulinumtoxinA for treating CD from the UK payer perspective. METHODS: A Markov model was developed to evaluate the cost-effectiveness of abobotulinum-toxinA versus best supportive care (BSC) in CD, with a lifetime horizon and health states for response, nonresponse, secondary nonresponse, and BSC in patients with CD (mean age: 53 years; 37% male)...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28431634/multicenter-observational-study-of-abobotulinumtoxina-neurotoxin-in-cervical-dystonia-the-anchor-cd-registry
#19
Richard M Trosch, Alberto J Espay, Daniel Truong, Ramon Gil, Carlos Singer, Peter A LeWitt, Mark F Lew, Michele Tagliati, Charles H Adler, Jack J Chen, Dominic Marchese, Cynthia L Comella
BACKGROUND: The ANCHOR-CD prospective observational registry study evaluated the effectiveness of abobotulinumtoxinA in adult idiopathic cervical dystonia (CD) in clinical practice. METHODS: Adults with CD were eligible. Treating physicians determined abobotulinumtoxinA dose and treatment interval. The primary endpoint was patient response rate (Toronto Western Spasmodic Torticollis Rating Scale [TWSTRS] score reduction≥25% and Patient Global Impression of Change [PGIC] score of +2 or +3 at Week 4 of Cycle 1)...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28239516/nonmotor-symptoms-in-primary-adult-onset-cervical-dystonia-and-blepharospasm
#20
Jing Yang, Na Shao, Wei Song, Qianqian Wei, Ruwei Ou, Ying Wu, Hui-Fang Shang
BACKGROUND: The nature and frequency of nonmotor symptoms in primary adult-onset cervical dystonia (CD) and blepharospasm (BSP) patients in Chinese populations remain unknown. METHODS: Hamilton's Depression Scale (HAMD), Hamilton's Anxiety Scale (HAMA), Addenbrooke's Cognitive Examination Revised (ACE-R), Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale were used to evaluate NMS in 120 patients with primary focal adult-onset dystonia (60 with BSP and 60 with CD) and 60 age-, sex-, and education level- matched healthy controls (HCs)...
February 2017: Brain and Behavior
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