Fiachra Humphries, Liraz Shmuel-Galia, Zhaozhao Jiang, Jeffrey Y Zhou, Leonard Barasa, Santanu Mondal, Ruth Wilson, Nadia Sultana, Scott A Shaffer, Sze-Ling Ng, G Scott Pesiridis, Paul R Thompson, Katherine A Fitzgerald
Stimulator of interferon genes (STING) is an essential adaptor protein required for the inflammatory response to cytosolic DNA. dsDNA activates cGAS to generate cGAMP, which binds and activates STING triggering a conformational change, oligomerization, and the IRF3- and NFκB-dependent transcription of type I Interferons (IFNs) and inflammatory cytokines, as well as the activation of autophagy. Aberrant activation of STING is now linked to a growing number of both rare as well as common chronic inflammatory diseases...
August 15, 2023: Proceedings of the National Academy of Sciences of the United States of America