Gail Hayward, Sam Mort, Alastair D Hay, Michael Moore, Nicholas P B Thomas, Johanna Cook, Jared Robinson, Nicola Williams, Nicola Maeder, Rebecca Edeson, Marloes Franssen, Jenna Grabey, Margaret Glogowska, Yaling Yang, Julie Allen, Christopher C Butler
IMPORTANCE: Recurrent urinary tract infection (UTI) is a common debilitating condition in women, with limited prophylactic options. d-Mannose has shown promise in trials based in secondary care, but effectiveness in placebo-controlled studies and community settings has not been established. OBJECTIVE: To determine whether d-mannose taken for 6 months reduces the proportion of women with recurrent UTI experiencing a medically attended UTI. DESIGN, SETTING, AND PARTICIPANTS: This 2-group, double-blind randomized placebo-controlled trial took place across 99 primary care centers in the UK...
April 8, 2024: JAMA Internal Medicine