keyword
https://read.qxmd.com/read/38516412/thyroid-hormone-action-in-adult-neurogliogenic-niches-the-known-and-unknown
#21
REVIEW
Victor Valcárcel-Hernández, Steffen Mayerl, Ana Guadaño-Ferraz, Sylvie Remaud
Over the last decades, thyroid hormones (THs) signaling has been established as a key signaling cue for the proper maintenance of brain functions in adult mammals, including humans. One of the most fascinating roles of THs in the mature mammalian brain is their ability to regulate adult neurogliogenic processes. In this respect, THs control the generation of new neuronal and glial progenitors from neural stem cells (NSCs) as well as their final differentiation and maturation programs. In this review, we summarize current knowledge on the cellular organization of adult rodent neurogliogenic niches encompassing well-established niches in the subventricular zone (SVZ) lining the lateral ventricles, the hippocampal subgranular zone (SGZ), and the hypothalamus, but also less characterized niches in the striatum and the cerebral cortex...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38516258/nature-based-virtual-reality-intervention-to-manage-stress-in-family-caregivers-of-allogeneic-hematopoietic-stem-cell-transplant-recipients-a-two-phase-pilot-study-protocol
#22
JOURNAL ARTICLE
Lena J Lee, Elisa H Son, Nicole Farmer, Chantal Gerrard, Ralph Thadeus Tuason, Li Yang, Julie Kohn-Godbout, Cory Stephens, Eun-Shim Nahm, Leslie Smith, Steve Risch, Gwenyth R Wallen
UNLABELLED: Millions of family members and/or friends in the U.S. serve as unpaid caregivers for individuals with chronic conditions, such as cancer. Caregiving for someone undergoing an intense allogeneic hematopoietic stem cell transplant (HSCT) is particularly demanding, with accompanying physical and psychological stress. Increased stress and stress-related symptoms could make it difficult for caregivers to fulfill their roles and could negatively impact the health status and quality of life of themselves and the recipients...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38515647/early-postnatal-moderate-catch%C3%A2-up-growth-in-rats-with-nutritional-intrauterine-growth-restriction-preserves-pulmonary-vascular-and-cognitive-function-in-adulthood
#23
JOURNAL ARTICLE
Lixia Ye, Yajie Huang, Kewei Chen, Chengcheng Hang, Yuhan Ying, Lu Zu, Xiaofei Luo, Lizhong Du
Intrauterine growth restriction (IUGR) with rapid postnatal catch-up growth is strongly associated with pulmonary vascular dysfunction in adulthood, whereas IUGR with delayed growth in early postnatal life results in long-term brain deficits. In the present study, it was hypothesized that IUGR with early moderate catch-up growth may alleviate pulmonary vascular remodeling in adulthood without affecting memory function. An IUGR model was established by restricting maternal nutrition during pregnancy. Different growth patterns were achieved by adjusting the litter size in each group during lactation...
May 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38515317/the-relationship-between-hematologic-malignancies-on-male-hypogonadism-a-scoping-review
#24
JOURNAL ARTICLE
Bradley Roth, Muhammed A Moukhtar Hammad, Daniel I Sanford, Molly Piper, David W Barham, Faysal A Yafi, Lawrence C Jenkins
INTRODUCTION: The associated symptoms of hypogonadism have been reported in patients with various types of cancer. However, the prevalence and significance of hypogonadism among certain hematologic malignancies have not been completely summarized in recent literature. OBJECTIVE: In this review we aimed to examine the current literature on hypogonadism in patients with hematologic malignancies, with emphasis on leukemias, lymphomas, and multiple myeloma (MM). METHODS: This review included relevant studies published before July 2023 that were retrieved through a search of PubMed using the keywords "hematologic cancer," "hematologic malignancy," blood cancer," "leukemia," "lymphoma," "hypogonadism," "multiple myeloma," and "testosterone...
March 21, 2024: Sexual Medicine Reviews
https://read.qxmd.com/read/38515148/3d-printed-nanohydroxyapatite-methylacrylylated-silk-fibroin-scaffold-for-repairing-rat-skull-defects
#25
JOURNAL ARTICLE
Wu Huiwen, Liang Shuai, Xie Jia, Deng Shihao, Wei Kun, Yang Runhuai, Qian Haisheng, Li Jun
The repair of bone defects remains a major challenge in the clinic, and treatment requires bone grafts or bone replacement materials. Existing biomaterials have many limitations and cannot meet the various needs of clinical applications. To treat bone defects, we constructed a nanohydroxyapatite (nHA)/methylacrylylated silk fibroin (MASF) composite biological scaffold using photocurable 3D printing technology. In this study, scanning electron microscopy (SEM) was used to detect the changes in the morphological structure of the composite scaffold with different contents of nanohydroxyapatite, and FTIR was used to detect the functional groups and chemical bonds in the composite scaffold to determine the specific components of the scaffold...
March 21, 2024: Journal of Biological Engineering
https://read.qxmd.com/read/38514408/examining-the-effects-of-asiaticoside-on-dental-pulp-stem-cell-viability-and-proliferation-a-promising-approach-to-root-canal-treatment
#26
JOURNAL ARTICLE
Mohammad J Alazemi, Manal F Badawi, Mohamed G Elbeltagy, Amany E Badr
AIM: This study aims to evaluate the impact of asiaticoside (AC) on the viability and proliferation of dental pulp stem cells (DPSCs), considering the known negative effects of routinely used intracanal medicaments. This evaluation will be compared with the outcomes from using traditional intracanal medicaments, specifically triple antibiotic paste (TAP) and calcium hydroxide [Ca(OH)2 ]. MATERIALS AND METHODS: The DPSCs were obtained from the third molars of an adult donor...
February 1, 2024: Journal of Contemporary Dental Practice
https://read.qxmd.com/read/38514165/hepatic-veno-occlusive-disease-complicated-with-extreme-hyperammonaemia-920-%C3%A2%C2%B5mol-l-treated-with-defibrotide-lactulose-rifampin-and-haemodialysis
#27
JOURNAL ARTICLE
Maciej Kabat, Sarvarinder Gill, Kevin Kim, Karan Omidvari, Robert Lee
Hepatic veno-occlusive disease (VOD)/sinusoidal obstructive syndrome (SOS) is a severe complication that can occur following haematopoietic stem cell transplant (HSCT) with high-intensity conditioning chemotherapy regimens. Severe VOD/SOS, often characterised by multiorgan failure, is associated with a high mortality rate. This case report details the complex clinical course of a male patient in his mid-20s, recently diagnosed with B cell acute lymphoblastic leukaemia, who underwent allogeneic HSCT. Based on the 2023 European Society for Blood and Marrow Transplantation (EBMT) criteria, the patient developed very severe VOD/SOS, prompting immediate treatment with defibrotide...
March 21, 2024: BMJ Case Reports
https://read.qxmd.com/read/38512983/mice-with-renal-specific-alterations-of-stem-cell-associated-signaling-develop-symptoms-of-chronic-kidney-disease-but-surprisingly-no-tumors
#28
JOURNAL ARTICLE
Adam Myszczyszyn, Oliver Popp, Severine Kunz, Anje Sporbert, Simone Jung, Louis C Penning, Annika Fendler, Philipp Mertins, Walter Birchmeier
Previously, we found that Wnt and Notch signaling govern stem cells of clear cell kidney cancer (ccRCC) in patients. To mimic stem cell responses in the normal kidney in vitro in a marker-unbiased fashion, we have established tubular organoids (tubuloids) from total single adult mouse kidney epithelial cells in Matrigel and serum-free conditions. Deep proteomic and phosphoproteomic analyses revealed that tubuloids resembled renewal of adult kidney tubular epithelia, since tubuloid cells displayed activity of Wnt and Notch signaling, long-term proliferation and expression of markers of proximal and distal nephron lineages...
2024: PloS One
https://read.qxmd.com/read/38512963/communication-between-the-stem-cell-niche-and-an-adjacent-differentiation-niche-through-mirna-and-egfr-signaling-orchestrates-exit-from-the-stem-cell-state-in-the-drosophila-ovary
#29
JOURNAL ARTICLE
Jiani Chen, Chaoqun Li, Yifeng Sheng, Junwei Zhang, Lan Pang, Zhi Dong, Zhiwei Wu, Yueqi Lu, Zhiguo Liu, Qichao Zhang, Xueying Guan, Xuexin Chen, Jianhua Huang
The signaling environment, or niche, often governs the initial difference in behavior of an adult stem cell and a derivative that initiates a path towards differentiation. The transition between an instructive stem cell niche and differentiation niche must generally have single-cell resolution, suggesting that multiple mechanisms might be necessary to sharpen the transition. Here, we examined the Drosophila ovary and found that Cap cells, which are key constituents of the germline stem cell (GSC) niche, express a conserved microRNA (miR-124)...
March 21, 2024: PLoS Biology
https://read.qxmd.com/read/38512882/mtorc1-is-required-for-differentiation-of-germline-stem-cells-in-the-drosophila-melanogaster-testis
#30
JOURNAL ARTICLE
Marie Clémot, Cecilia D'Alterio, Alexa C Kwang, D Leanne Jones
Metabolism participates in the control of stem cell function and subsequent maintenance of tissue homeostasis. How this is achieved in the context of adult stem cell niches in coordination with other local and intrinsic signaling cues is not completely understood. The Target of Rapamycin (TOR) pathway is a master regulator of metabolism and plays essential roles in stem cell maintenance and differentiation. In the Drosophila male germline, mTORC1 is active in germline stem cells (GSCs) and early germ cells...
2024: PloS One
https://read.qxmd.com/read/38511806/covid-19-in-hematopoietic-stem-cell-transplant-recipients-during-three-years-of-the-pandemic-a-multicenter-study-in-brazil
#31
JOURNAL ARTICLE
Bruno Azevedo Randi, Hermes Ryoiti Higashino, Vinícius Ponzio da Silva, Matias Chiarastelli Salomão, Antonio Carlos Campos Pignatari, Edson Abdala, Fabiana Vasques, Celso Arrais Rodrigues da Silva, Roberto Luiz da Silva, Carolina Dos Santos Lazari, José Eduardo Levi, Erick Menezes Xavier, Marina Farrel Côrtes, Alessandra Luna-Muschi, Vanderson Rocha, Silvia Figueiredo Costa
Hematopoietic stem cell transplant (HSCT) recipients are at -increased risk for severe COVID-19. The aim of this study was to evaluate the burden of COVID-19 in a cohort of HSCT recipients. This retrospective study evaluated a cohort of adult hospitalized HSCT recipients diagnosed with COVID-19 in two large hospitals in São Paulo, Brazil post-HSCT, from January 2020 to June 2022. The primary outcome was all-cause mortality. Of 49 cases, 63.2% were male with a median age of 47 years. Allogeneic-HSCT (51...
2024: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/38511389/impact-of-donor-nkg2d-and-mica-gene-polymorphism-on-clinical-outcomes-of-adult-and-paediatric-allogeneic-cord-blood-transplantation-for-malignant-diseases
#32
JOURNAL ARTICLE
Steven T Cox, Warren Patterson, Richard Duggleby, Owen J R Jones, J Alejandro Madrigal, Sergi Querol, Francesc Rudilla Salvador, Maria Jose Herrero Mata, Fernanda Volt, Éliane Gluckman, Richard Szydlo, Robert D Danby, Diana Hernandez
OBJECTIVES: NKG2D is an activating receptor expressed by natural killer (NK) and CD8+ T cells and activation intensity varies by NKG2D expression level or nature of its ligand. An NKG2D gene polymorphism determines high (HNK1) or low (LNK1) expression. MICA is the most polymorphic NKG2D ligand and stronger effector cell activation associates with methionine rather than valine at residue 129. We investigated correlation between cord blood (CB) NKG2D and MICA genotypes and haematopoietic stem cell (HSC) transplant outcome...
March 21, 2024: European Journal of Haematology
https://read.qxmd.com/read/38510289/functional-validation-of-doxorubicin-induced-cardiotoxicity-related-genes
#33
JOURNAL ARTICLE
Hananeh Fonoudi, Mariam Jouni, Romina B Cejas, Tarek Magdy, Malorie Blancard, Ning Ge, Disheet A Shah, Davi M Lyra-Leite, Achal Neupane, Mennat Gharib, Zhengxin Jiang, Yadav Sapkota, Paul W Burridge
BACKGROUND: Genome-wide association studies and candidate gene association studies have identified more than 180 genetic variants statistically associated with anthracycline-induced cardiotoxicity (AIC). However, the lack of functional validation has hindered the clinical translation of these findings. OBJECTIVES: The aim of this study was to functionally validate all genes associated with AIC using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)...
February 2024: JACC CardioOncology
https://read.qxmd.com/read/38509752/characterization-of-prame-immunohistochemistry-reveals-lower-expression-in-pediatric-melanoma-compared-to-adult-melanoma
#34
JOURNAL ARTICLE
Stephan Forchhammer, Valentin Aebischer, Daniela Lenders, Christian M Seitz, Christopher Schroeder, Alexandra Liebmann, Michael Abele, Hannah Wild, Ewa Bien, Malgorzata Krawczyk, Dominik T Schneider, Ines B Brecht, Lukas Flatz, Matthias Hahn
Pediatric melanomas are rare tumors that have clinical and histological differences from adult melanomas. In adult melanoma, the immunohistochemical marker PRAME is increasingly employed as a diagnostic adjunct. PRAME is also under investigation as a target structure for next-generation immunotherapies including T-cell engagers. Little is known about the characteristics of PRAME expression in pediatric melanoma. In this retrospective study, samples from 25 pediatric melanomas were compared with control groups of melanomas in young adults (18-30 years; n = 32), adult melanoma (>30 years, n = 30), and benign melanocytic nevi in children (0-18 years; n = 30) with regard to the immunohistochemical expression of PRAME (diffuse PRAME expression >75%/absolute expression)...
March 20, 2024: Pigment Cell & Melanoma Research
https://read.qxmd.com/read/38509074/dmrta2-supports-glioma-stem-cell-mediated-neovascularization-in-glioblastoma
#35
JOURNAL ARTICLE
Marta Maleszewska, Kamil Wojnicki, Jakub Mieczkowski, Sylwia K Król, Karol Jacek, Magdalena Śmiech, Marta Kocyk, Iwona A Ciechomska, Mateusz Bujko, Janusz Siedlecki, Katarzyna Kotulska, Wiesława Grajkowska, Małgorzata Zawadzka, Bozena Kaminska
Glioblastoma (GBM) is the most common and lethal brain tumor in adults. Due to its fast proliferation, diffusive growth and therapy resistance survival times are less than two years for patients with IDH-wildtype GBM. GBM is noted for the considerable cellular heterogeneity, high stemness indices and abundance of the glioma stem-like cells known to support tumor progression, therapeutic resistance and recurrence. Doublesex- and mab-3-related transcription factor a2 (DMRTA2) is involved in maintaining neural progenitor cells (NPC) in the cell cycle and its overexpression suppresses NPC differentiation...
March 20, 2024: Cell Death & Disease
https://read.qxmd.com/read/38508693/the-genome-of-the-colonial-hydroid-hydractinia-reveals-their-stem-cells-utilize-a-toolkit-of-evolutionarily-shared-genes-with-all-animals
#36
JOURNAL ARTICLE
Christine E Schnitzler, E Sally Chang, Justin Waletich, Gonzalo Quiroga-Artigas, Wai Yee Wong, Anh-Dao Nguyen, Sofia Barreira, Liam B Doonan, Paul Gonzalez, Sergey Koren, James Gahan, Steven Sanders, Brian Bradshaw, Timothy DuBuc, Febrimarsa Febrimarsa, Danielle de Jong, Eric Nawrocki, Alexandra Larson, Samantha Klasfeld, Sebastian Gornik, R Travis Moreland, Tyra Wolfsberg, Adam M Phillippy, James Mullikin, Oleg Simakov, Paulyn Cartwright, Matthew Nicotra, Uri Frank, Andreas D Baxevanis
Hydractinia is a colonial marine hydroid that exhibits remarkable biological properties, including the capacity to regenerate its entire body throughout its lifetime, a process made possible by its adult migratory stem cells, known as i-cells. Here, we provide an in-depth characterization of the genomic structure and gene content of two Hydractinia species, H. symbiolongicarpus and H. echinata , placing them in a comparative evolutionary framework with other cnidarian genomes. We also generated and annotated a single-cell transcriptomic atlas for adult male H...
March 20, 2024: Genome Research
https://read.qxmd.com/read/38508444/hspa9-mortalin-inhibition-disrupts-erythroid-maturation-through-a-tp53-dependent-mechanism-in-human-cd34-hematopoietic-progenitor-cells
#37
JOURNAL ARTICLE
Christopher Butler, Morgan Dunmire, Jaebok Choi, Gabor Szalai, Anissa Johnson, Wei Lei, Xin Chen, Liang Liu, Wei Li, Matthew J Walter, Tuoen Liu
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell malignancies characterized by abnormal hematopoietic cell maturation, increased apoptosis of bone marrow cells, and anemia. They are the most common myeloid blood cancers in American adults. The full complement of gene mutations that contribute to the phenotypes or clinical symptoms in MDS is not fully understood. Around 10%-25% of MDS patients harbor an interstitial heterozygous deletion on the long arm of chromosome 5 [del(5q)], creating haploinsufficiency for a large set of genes, including HSPA9...
March 18, 2024: Cell Stress & Chaperones
https://read.qxmd.com/read/38507212/isolation-of-murine-neonatal-and-adult-osteomacs-to-examine-their-role-in-the-hematopoietic-niche
#38
JOURNAL ARTICLE
Safa F Mohamad, Melissa A Kacena
Maintenance of hematopoietic stem cell (HSC) function is an orchestrated event between multiple cell types, and crosstalk between these cell types is an essential part of HSC regulation. Among the cell groups of the niche involved in this process are a group of bone-resident macrophages known as osteomacs (OM). Previously, it was demonstrated that OM and osteoblasts contained within neonatal calvarial cells are critical to maintain hematopoietic function. Additionally, interactions between neonatal calvarial cells and megakaryocytes further enhance this hematopoietic activity...
March 21, 2024: Methods in Molecular Biology
https://read.qxmd.com/read/38506536/the-role-of-lipids-in-genome-integrity-and-pluripotency
#39
JOURNAL ARTICLE
Qiyu Tian, Hoyoung Chung, Duancheng Wen
Pluripotent stem cells (PSCs), comprising embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), offer immense potential for regenerative medicine due to their ability to differentiate into all cell types of the adult body. A critical aspect of harnessing this potential is understanding their metabolic requirements during derivation, maintenance, and differentiation in vitro. Traditional culture methods using fetal bovine serum often lead to issues such as heterogeneous cell populations and diminished pluripotency...
March 20, 2024: Biochemical Society Transactions
https://read.qxmd.com/read/38503291/sox17-etv2-improves-the-direct-reprogramming-of-adult-fibroblasts-to-endothelial-cells
#40
JOURNAL ARTICLE
Alexander Grath, Guohao Dai
An autologous source of vascular endothelial cells (ECs) is valuable for vascular regeneration and tissue engineering without the concern of immune rejection. The transcription factor ETS variant 2 (ETV2) has been shown to directly convert patient fibroblasts into vascular EC-like cells. However, reprogramming efficiency is low and there are limitations in EC functions, such as eNOS expression. In this study, we directly reprogram adult human dermal fibroblasts into reprogrammed ECs (rECs) by overexpressing SOX17 in conjunction with ETV2...
March 12, 2024: Cell Rep Methods
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