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https://www.readbyqxmd.com/read/29471003/trkb-receptor-antagonism-inhibits-stab-injury-induced-proliferative-response-in-adult-zebrafish-danio-rerio-brain
#1
Surendra Kumar Anand, Amal Chandra Mondal
The Tropomyosin related kinase (TrkB) receptor, is known to promote neuronal maturation, differentiation, maintenance and survival through its cognate ligands Brain derived neurotrophic factor (BDNF) and neurotrophin 4 (NT4). BDNF, NT4 and TrkB are highly conserved proteins among vertebrates. Although the role of TrkB during brain development is well established, its role in adult neurogenesis and brain regeneration awaits thorough investigation. In this study, we used the zebrafish stab wound injury model to determine whether the injury induced regeneration response in the telencephalon region is governed by TrkB or not...
February 19, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29469924/t-cell-depleted-haploidentical-stem-cell-transplantation-results-improve-with-time-in-adults-with-acute-leukemia-a-study-from-the-acute-leukemia-working-party-of-the-european-society-of-blood-and-marrow-transplantation-ebmt
#2
Simona Sestili, Myriam Labopin, Annalisa Ruggeri, Andrea Velardi, Fabio Ciceri, Johan Maertens, Lothar Kanz, Franco Aversa, Philippe Lewalle, Donald Bunjes, Mohamad Mohty, Arnon Nagler
BACKGROUND: T-cell-depleted, haploidentical transplantations (haplos) are commonly offered to patients who have high-risk, acute leukemia in the absence of a human leukocyte antigen (HLA) full-matched donor. METHODS: To determine the effect of transplantation period, the authors divided 308 adults with de novo, acute leukemia who underwent T-cell-depleted haplo from 2005 to 2015 into 2 groups, according the year in which they underwent transplantation (2005-2011 [n = 191] and 2012-2015 [n = 117])...
February 22, 2018: Cancer
https://www.readbyqxmd.com/read/29468647/brentuximab-vedotin-prior-to-allogeneic-stem-cell-transplantation-in-hodgkin-lymphoma-a-report-from-the-ebmt-lymphoma-working-party
#3
Ali Bazarbachi, Ariane Boumendil, Hervé Finel, Mohamad Mohty, Luca Castagna, Karl S Peggs, Didier Blaise, Boris Afanasyev, José L Diez-Martin, Jorge Sierra, Adrian Bloor, Carmen Martinez, Stephen Robinson, Ram Malladi, Jean El-Cheikh, Paolo Corradini, Silvia Montoto, Peter Dreger, Anna Sureda
Brentuximab vedotin (BV) is an anti-CD30 antibody-drug conjugate. Preliminary data suggest that BV might improve outcomes after allogeneic stem cell transplantation (SCT) for Hodgkin lymphoma (HL) when used as pre-transplant salvage therapy. Between 2010 and 2014, 428 adult patients underwent an allogeneic SCT for classical HL at participating centres of the European Society for Blood and Marrow Transplantation. We compared the outcomes of 210 patients who received BV prior to allogeneic SCT with that of 218 patients who did not receive BV...
February 22, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29468631/high-dose-melphalan-based-sequential-conditioning-chemotherapy-followed-by-allogeneic-haematopoietic-stem-cell-transplantation-in-adult-patients-with-relapsed-or-refractory-acute-myeloid-leukaemia
#4
Nina K Steckel, Christoph Groth, Jan-Henrik Mikesch, Rudolf Trenschel, Hellmut Ottinger, Lambros Kordelas, Carsten Mueller-Tidow, Christoph Schliemann, Christian Reicherts, Joern C Albring, Gerda Silling, Eva Schmidt, Wolfgang E Berdel, Georg Lenz, Markus Ditschkowski, Dietrich W Beelen, Matthias Stelljes
Considering the unsatisfactory results of salvage therapies for patients with relapsed/refractory acute myeloid leukaemia (R/R-AML), their value before allogeneic haematopoietic stem cell transplantation (HSCT) remains questionable. However, direct allogeneic HSCT following established conditioning regimens applied in patients with R/R-AML during active disease has been equally disappointing. In this retrospective observational study, high-dose melphalan, as part of a sequential preparative regimen, followed by a total body irradiation (4 × 2 Gy)-based or a treosulfan-based dose-adapted conditioning therapy for allogeneic HSCT was administered to 292 adult patients (median age 56 years, range 17-74) with primary refractory (144 patients), secondary refractory (97 patients) or relapsed AML (51 patients)...
February 21, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29467947/metformin-inhibits-tgf-%C3%AE-1-induced-epithelial-to-mesenchymal-transition-like-process-and-stem-like-properties-in-gbm-via-akt-mtor-zeb1-pathway
#5
Yang Song, Yong Chen, Yunqian Li, Xiaoyan Lyu, Jiayue Cui, Ye Cheng, Liyan Zhao, Gang Zhao
Glioblastoma (GBM) is the most frequent and aggressive brain tumor in adults. In spite of advances in diagnosis and therapy, the prognosis is still relatively poor. The invasive property of GBM is the major cause of death in patients. Epithelial-to-mesenchymal transition-like process (EMT-like process) is considered to play an important role in the invasive property. Metformin has been reported as a regulator of EMT-like process. In this study, we confirmed that metformin inhibited TGF-β1-induced EMT-like process and EMT-associated migration and invasion in LN18 and U87 GBM cells...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467678/structural-immaturity-of-human-ipsc-derived-cardiomyocytes-in-silico-investigation-of-effects-on-function-and-disease-modeling
#6
Jussi T Koivumäki, Nikolay Naumenko, Tomi Tuomainen, Jouni Takalo, Minna Oksanen, Katja A Puttonen, Šárka Lehtonen, Johanna Kuusisto, Markku Laakso, Jari Koistinaho, Pasi Tavi
Background: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising experimental tool for translational heart research and drug development. However, their usability as a human adult cardiomyocyte model is limited by their functional immaturity. Our aim is to analyse quantitatively those characteristics and how they differ from adult CMs. Methods and Results: We have developed a novel in silico model with all essential functional electrophysiology and calcium handling features of hiPSC-CMs...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29467668/identification-and-functional-analysis-of-the-first-aquaporin-from-striped-stem-borer-chilo-suppressalis
#7
Ming-Xing Lu, Dan-Dan Pan, Jing Xu, Yang Liu, Gui-Rong Wang, Yu-Zhou Du
Aquaporins are integral membrane proteins some of which form high capacity water-selective channels, promoting water permeation across cell membranes. In this study, we isolated the aquaporin transcript ( Cs Drip1) of Chilo suppressalis , one of the important rice pests. Cs Drip1 included two variants, Cs Drip1_v1 and Cs Drip1_v2. Although Cs Drip1_v2 sequence (>409 bp) was longer than Cs Drip1_v1, they possessed the same open reading frame (ORF). Protein structure and topology of Cs Drip1 was analyzed using a predicted model, and the results demonstrated the conserved properties of insect water-specific aquaporins, including 6 transmembrane domains, 2 NPA motifs, ar/R constriction region (Phe69 , His194 , Ser203 , and Arg209 ) and the C-terminal peptide sequence ending in "SYDF...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29467625/effect-of-vitamin-d-in-hn9-10e-embryonic-hippocampal-cells-and-in-hippocampus-from-mptp-induced-parkinson-s-disease-mouse-model
#8
Samuela Cataldi, Cataldo Arcuri, Stéphane Hunot, Carmen Mecca, Michela Codini, Maria E Laurenti, Ivana Ferri, Elisabetta Loreti, Mercedes Garcia-Gil, Giovanna Traina, Carmela Conte, Francesco S Ambesi-Impiombato, Tommaso Beccari, Francesco Curcio, Elisabetta Albi
It has long been proven that neurogenesis continues in the adult brains of mammals in the dentatus gyrus of the hippocampus due to the presence of neural stem cells. Although a large number of studies have been carried out to highlight the localization of vitamin D receptor in hippocampus, the expression of vitamin D receptor in neurogenic dentatus gyrus of hippocampus in Parkinson's disease (PD) and the molecular mechanisms triggered by vitamin D underlying the production of differentiated neurons from embryonic cells remain unknown...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29467485/the-cell-fate-determinant-scribble-is-required-for-maintenance-of-hematopoietic-stem-cell-function
#9
Juliane Mohr, Banaja P Dash, Tina M Schnoeder, Denise Wolleschak, Carolin Herzog, Nuria Tubio Santamaria, Sönke Weinert, Sonika Godavarthy, Costanza Zanetti, Michael Naumann, Björn Hartleben, Tobias B Huber, Daniela S Krause, Thilo Kähne, Lars Bullinger, Florian H Heidel
Cell fate determinants influence self-renewal potential of hematopoietic stem cells. Scribble and Llgl1 belong to the Scribble polarity complex and reveal tumor-suppressor function in drosophila. In hematopoietic cells, genetic inactivation of Llgl1 leads to expansion of the stem cell pool and increases self-renewal capacity without conferring malignant transformation. Here we show that genetic inactivation of its putative complex partner Scribble results in functional impairment of hematopoietic stem cells (HSC) over serial transplantation and during stress...
January 30, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29467462/hipsc-derived-neural-stem-cells-from-patients-with-schizophrenia-induce-an-impaired-angiogenesis
#10
Bárbara S Casas, Gabriela Vitória, Marcelo N do Costa, Rodrigo Madeiro da Costa, Pablo Trindade, Renata Maciel, Nelson Navarrete, Stevens K Rehen, Verónica Palma
Schizophrenia is a neurodevelopmental disease characterized by cerebral connectivity impairment and loss of gray matter. It was described in adult schizophrenia patients (SZP) that concentration of VEGFA, a master angiogenic factor, is decreased. Recent evidence suggests cerebral hypoperfusion related to a dysfunctional Blood Brain Barrier (BBB) in SZP. Since neurogenesis and blood-vessel formation occur in a coincident and coordinated fashion, a defect in neurovascular development could result in increased vascular permeability and, therefore, in poor functionality of the SZP's neurons...
February 22, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29467410/analysis-of-cardiomyocyte-clonal-expansion-during-mouse-heart-development-and-injury
#11
Konstantina-Ioanna Sereti, Ngoc B Nguyen, Paniz Kamran, Peng Zhao, Sara Ranjbarvaziri, Shuin Park, Shan Sabri, James L Engel, Kevin Sung, Rajan P Kulkarni, Yichen Ding, Tzung K Hsiai, Kathrin Plath, Jason Ernst, Debashis Sahoo, Hanna K A Mikkola, M Luisa Iruela-Arispe, Reza Ardehali
The cellular mechanisms driving cardiac tissue formation remain poorly understood, largely due to the structural and functional complexity of the heart. It is unclear whether newly generated myocytes originate from cardiac stem/progenitor cells or from pre-existing cardiomyocytes that re-enter the cell cycle. Here, we identify the source of new cardiomyocytes during mouse development and after injury. Our findings suggest that cardiac progenitors maintain proliferative potential and are the main source of cardiomyocytes during development; however, the onset of αMHC expression leads to reduced cycling capacity...
February 21, 2018: Nature Communications
https://www.readbyqxmd.com/read/29467395/spatial-geometry-of-stem-cell-proliferation-in-the-adult-hippocampus
#12
Olga A Mineyeva, Grigori Enikolopov, Alexei A Koulakov
The modes of stem cell divisions (e.g., symmetric vs. asymmetric) can have a profound impact on the number of progeny and tissue growth, repair, and function. This is particularly relevant for adult neural stem cells, since stem cell-derived neurons affect cognitive and mental states, resistance to stress and disease, and response to therapies. Here we show that although dividing stem cells in the adult hippocampus display a certain bias towards paired distribution (which could imply the prevalence of symmetric divisions), this bias already exists in the distribution of the general population of stem cells and may be responsible for the perceived occurrence of symmetric stem cell divisions...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29467020/insulin-like-growth-factor-1-mediated-regulation-of-mir-193a-expression-promotes-the-migration-and-proliferation-of-c-kit-positive-mouse-cardiac-stem-cells
#13
Yuning Sun, Rongfeng Xu, Jia Huang, Yuyu Yao, Xiaodong Pan, Zhongpu Chen, Genshan Ma
BACKGROUND: C-kit-positive cardiac stem cells (CSCs) have been shown to be a promising candidate treatment for myocardial infarction and heart failure. Insulin-like growth factor (IGF)-1 is an anabolic growth hormone that regulates cellular proliferation, differentiation, senescence, and death in various tissues. Although IGF-1 promotes the migration and proliferation of c-kit-positive mouse CSCs, the underlying mechanism remains unclear. METHODS: Cells were isolated from adult mouse hearts, and c-kit-positive CSCs were separated using magnetic beads...
February 21, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29466726/tet2-rescues-age-related-regenerative-decline-and-enhances-cognitive-function-in-the-adult-mouse-brain
#14
Geraldine Gontier, Manasi Iyer, Jeremy M Shea, Gregor Bieri, Elizabeth G Wheatley, Miguel Ramalho-Santos, Saul A Villeda
Restoring adult stem cell function provides an exciting approach for rejuvenating the aging brain. However, molecular mechanisms mediating neurogenic rejuvenation remain elusive. Here we report that the enzyme ten eleven translocation methylcytosine dioxygenase 2 (Tet2), which catalyzes the production of 5-hydroxymethylcytosine (5hmC), rescues age-related decline in adult neurogenesis and enhances cognition in mice. We detected a decrease in Tet2 expression and 5hmC levels in the aged hippocampus associated with adult neurogenesis...
February 20, 2018: Cell Reports
https://www.readbyqxmd.com/read/29463756/diagnostic-utility-of-telomere-length-testing-in-a-hospital-based-setting
#15
Jonathan K Alder, Vidya Sagar Hanumanthu, Margaret A Strong, Amy E DeZern, Susan E Stanley, Clifford M Takemoto, Ludmilla Danilova, Carolyn D Applegate, Stephen G Bolton, David W Mohr, Robert A Brodsky, James F Casella, Carol W Greider, J Brooks Jackson, Mary Armanios
Telomere length (TL) predicts the onset of cellular senescence in vitro but the diagnostic utility of TL measurement in clinical settings is not fully known. We tested the value of TL measurement by flow cytometry and FISH (flowFISH) in patients with mutations in telomerase and telomere maintenance genes. TL had a discrete and reproducible normal range with definable upper and lower boundaries. While TL above the 50th age-adjusted percentile had a 100% negative predictive value for clinically relevant mutations, the lower threshold in mutation carriers was age-dependent, and adult mutation carriers often overlapped with the lowest decile of controls...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29463446/how-to-treat-chronic-myeloid-leukemia-cml-in-older-adults
#16
Marlise R Luskin, Daniel J DeAngelo
Chronic myeloid leukemia (CML), a myeloproliferative neoplasm defined by the t(9;22)(q34;q11) chromosomal translocation, primarily affects older adults. Historically, effective treatment options were not available for older CML patients ineligible for curative allogeneic stem cell transplant, and the disease was therefore usually fatal within several years of diagnosis. The development of tyrosine kinase inhibitors (TKIs) that effectively target the constitutively active mutant tyrosine kinase in CML has dramatically improved outcomes for all patients with CML, including older patients...
February 18, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29463313/lymphotoxin-%C3%AE-receptor-mediated-nf%C3%AE%C2%BAb-signaling-promotes-glial-lineage-differentiation-and-inhibits-neuronal-lineage-differentiation-in-mouse-brain-neural-stem-progenitor-cells
#17
Xiao Xiao, Raj Putatunda, Yonggang Zhang, Priya V Soni, Fang Li, Ting Zhang, Mingyang Xin, Jin Jun Luo, John R Bethea, Yuan Cheng, Wenhui Hu
BACKGROUND: Lymphotoxin (LT) is a lymphokine mainly expressed in lymphocytes. LTα binds one or two membrane-associated LTβ to form LTα2 β1 or LTα1 β2 heterotrimers. The predominant LTα1 β2 binds to LTβ receptor (LTβR) primarily expressed in epithelial and stromal cells. Most studies on LTβR signaling have focused on the organization, development, and maintenance of lymphoid tissues. However, the roles of LTβR signaling in the nervous system, particularly in neurogenesis, remain unknown...
February 20, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29462960/the-role-of-wnt-signal-in-glioblastoma-development-and-progression-a-possible-new-pharmacological-target-for-the-therapy-of-this-tumor
#18
REVIEW
Mariachiara Zuccarini, Patricia Giuliani, Sihana Ziberi, Marzia Carluccio, Patrizia Di Iorio, Francesco Caciagli, Renata Ciccarelli
Wnt is a complex signaling pathway involved in the regulation of crucial biological functions such as development, proliferation, differentiation and migration of cells, mainly stem cells, which are virtually present in all embryonic and adult tissues. Conversely, dysregulation of Wnt signal is implicated in development/progression/invasiveness of different kinds of tumors, wherein a certain number of multipotent cells, namely "cancer stem cells", are characterized by high self-renewal and aggressiveness...
February 17, 2018: Genes
https://www.readbyqxmd.com/read/29462202/thymic-b-cell-development-is-controlled-by-the-b-potential-of-progenitors-via-both-hematopoietic-intrinsic-and-thymic-microenvironment-intrinsic-regulatory-mechanisms
#19
Shiyun Xiao, Wen Zhang, Nancy R Manley
BACKGROUND: Hematopoietic stem cells (HSCs) derived from birth through adult possess differing differentiation potential for T or B cell fate in the thymus; neonatal bone marrow (BM) cells also have a higher potential for B cell production in BM compared to adult HSCs. We hypothesized that this hematopoietic-intrinsic B potential might also regulate B cell development in the thymus during ontogeny. METHODS: Foxn1lacZ mutant mice are a model in which down regulation of a thymic epithelial cell (TEC) specific transcription factor beginning one week postnatal causes a dramatic reduction of thymocytes production...
2018: PloS One
https://www.readbyqxmd.com/read/29462197/thymic-epithelial-cell-derived-signals-control-b-progenitor-formation-and-proliferation-in-the-thymus-by-regulating-let-7-and-arid3a
#20
Shiyun Xiao, Wen Zhang, Nancy R Manley
The postnatal thymus is an efficient microenvironment for T cell specification and differentiation. B cells are also present in the thymus and have been recently shown to impact T cell selection, however, the mechanisms controlling B cell development in the thymus are largely unknown. In Foxn1lacZ mutant mice, down-regulation of Foxn1 expression in thymic epithelial cells beginning 1 week after birth caused a dramatic reduction of T progenitors and an increase of B cell progenitors. This time point is coincident with the switch from fetal to adult-type hematopoietic stem cells (HSCs), which is regulated by the Lin28-Let7 system...
2018: PloS One
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