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https://www.readbyqxmd.com/read/28724210/dandelion-root-extract-suppressed-gastric-cancer-cells-proliferation-and-migration-through-targeting-lncrna-ccat1
#1
Huanhuan Zhu, Hangyong Zhao, Linjie Zhang, Jianmin Xu, Chunhua Zhu, Hui Zhao, Guoqiang Lv
Gastric cancer (GC) is one of the most common tumors worldwide. Standard treatment after early detection involves surgical excision (recurrence is possible), and metastatic gastric cancer is refractory to immuno-, radio-, and most harmful chemotherapies. Various natural compounds have shown efficacy in killing different cancers, albeit not always specifically. In this study, we show that dandelion root extract (DRE) specifically and effectively suppresses proliferation and migration in human gastric cells without inducing toxicity in noncancerous cells...
July 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28723861/medicaid-and-uninsured-hepatocellular-carcinoma-patients-have-more-advanced-tumor-stage-and-are-less-likely-to-receive-treatment
#2
Jennifer Wang, John Ha, Aristeo Lopez, Taft Bhuket, Benny Liu, Robert J Wong
GOALS: To evaluate the impact of insurance status on tumor stage at diagnosis, treatment received, and overall survival among adults with hepatocellular carcinoma (HCC). BACKGROUND: Insurance status affects access to care, which impacts timely access to cancer screening for early detection and treatment. STUDY: Using the 2007 to 2012 Surveillance, Epidemiology, and End Results (SEER) database, we retrospectively evaluated US adults with HCC...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28723792/concomitant-stromal-tumor-and-early-cancer-of-the-stomach-what-should-be-done
#3
Yan Xu, Liangfang Shen, Zhaoxia Lu, Xiaowei Liu, Wei Wu, Deyun Feng, Jaladanki N Rao, Lan Xiao, Miao Ouyang
Concomitant gastric stromal tumor (GST) and gastric cancer (GC) is uncommon; even more uncommon is a concomitant GST and early stage GC (EGC). Tumor resection by endoscopic submucosal dissection (ESD) for concomitant GST and EGC has not been reported. We sought to define the clinical importance of detection of concomitant GST and EGC during the first esophagogastroduodenoscopy (EGD), and compare the clinical outcomes of ESD versus radical surgery for the treatment of concomitant GST and EGC. Our investigation was a retrospective cohort study...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723690/distribution-of-human-papillomavirus-genotypes-among-women-in-mashhad-iran
#4
Eskandar Taghizadeh, Forough Taheri, Hamed Abdolkarimi, Pedram Ghorbani Renani, Seyed Mohammad Gheibi Hayat
OBJECTIVE: Cervical cancer is the third most common malignancy in females. Since the human papillomavirus (HPV) genotype can vary geographically, it is essential to define its genotypic distribution before establishing health care policies and vaccination programs in any given area. The aim of this study was to determine the frequency of HPV types in women in Mashhad, Iran. METHODS: We used nested PCR and reverse dot-blot hybridization for genotyping. The study included 143 cervical cytology samples from Mashhad with confirmed papillomavirus infection by molecular methods...
July 20, 2017: Intervirology
https://www.readbyqxmd.com/read/28723659/data-driven-analysis-of-immune-infiltrate-in-a-large-cohort-of-breast-cancer-and-its-association-with-disease-progression-er-activity-and-genomic-complexity
#5
Ruth Dannenfelser, Marianne Nome, Andliena Tahiri, Josie Ursini-Siegel, Hans Kristian Moen Vollan, Vilde D Haakensen, Åslaug Helland, Bjørn Naume, Carlos Caldas, Anne-Lise Børresen-Dale, Vessela N Kristensen, Olga G Troyanskaya
The tumor microenvironment is now widely recognized for its role in tumor progression, treatment response, and clinical outcome. The intratumoral immunological landscape, in particular, has been shown to exert both pro-tumorigenic and anti-tumorigenic effects. Identifying immunologically active or silent tumors may be an important indication for administration of therapy, and detecting early infiltration patterns may uncover factors that contribute to early risk. Thus far, direct detailed studies of the cell composition of tumor infiltration have been limited; with some studies giving approximate quantifications using immunohistochemistry and other small studies obtaining detailed measurements by isolating cells from excised tumors and sorting them using flow cytometry...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723144/inflection-point-of-the-localized-surface-plasmon-resonance-peak-a-general-method-to-improve-the-sensitivity
#6
Peng Chen, Nhung Thi Tran, Xinglin Wen, Qihua Xiong, Bo Liedberg
The shift of the localized surface plasmon resonance (LSPR) spectrum is widely used in bio- and chemical sensing. Traditionally, the shift is monitored at the peak maximum of the extinction spectrum. We demonstrate that the inflection point at the long wavelength side of the peak maximum shows better refractive index sensitivity than the peak maximum. A consistent improvement in bulk refractive index sensitivity of 18-55% is observed for six different nanoparticles such as spherical particles of different sizes, nanostar and nanorods with different aspect ratios...
February 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723094/structure-activity-relationships-reveal-key-features-of-8-oxoguanine-adenine-mismatch-detection-by-the-muty-dna-glycosylase
#7
Amelia H Manlove, Paige L McKibbin, Emily L Doyle, Chandrima Majumdar, Michelle L Hamm, Sheila S David
Base excision repair glycosylases locate and remove damaged based in DNA with remarkable specificity. The MutY glycosylases, unusual for their excision of undamaged adenines mispaired to the oxidized base 8-oxoguanine (OG), must recognize both bases of the mispair in order to prevent promutagenic activity. Moreover, MutY must effectively find OG:A mismatches within the context of highly abundant and structurally similar T:A base-pairs. Very little is known about the factors that initiate MutY's interaction with the substrate when it first encounters an intrahelical OG:A mispair, or about the order of recognition checkpoints...
July 19, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28722438/graphene-oxide-upconversion-nanoparticle-based-optical-sensors-for-targeted-detection-of-mrna-biomarkers-present-in-alzheimer-s-disease-and-prostate-cancer
#8
Patrick Vilela, Afaf El-Sagheer, Timothy M Millar, Tom Brown, Otto L Muskens, Antonios G Kanaras
The development of new sensors for the accurate detection of biomarkers in biological fluids is of utmost importance for the early diagnosis of diseases. Next to advanced laboratory techniques, there is a need for relatively simple methods which can significantly broaden the availability of diagnostic capability. Here, we demonstrate the successful application of a sensor platform based on graphene oxide and upconversion nanoparticles (NPs) for the specific detection of mRNA-related oligonucleotide markers in complex biological fluids...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722091/-analysis-of-lymph-node-metastasis-pattern-in-gastric-cancer-patients-at-stage-pn1
#9
Bin Ke, Ning Liu, Rupeng Zhang, Xiaofan Guo, Bin Li, Xuejun Wang, Han Liang
OBJECTIVE: To investigate the lymph node metastasis pattern in pN1 stage gastric cancer patients and to analyze its risk factors. METHODS: Clinicopathological data of 219 patients who underwent radical gastrectomy and were confirmed as pN1 stage gastric cancer between January 2013 and March 2016 were reviewed. All the patients underwent D2 or extended D2(D2+) lymphadenectomy. The overall metastatic rate was calculated. The risk factors associated with lymph node metastasis were analyzed...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28721928/strategic-roadmap-for-an-early-diagnosis-of-alzheimer-s-disease-based-on-biomarkers
#10
REVIEW
Giovanni B Frisoni, Marina Boccardi, Frederik Barkhof, Kaj Blennow, Stefano Cappa, Konstantinos Chiotis, Jean-Francois Démonet, Valentina Garibotto, Panteleimon Giannakopoulos, Anton Gietl, Oskar Hansson, Karl Herholz, Clifford R Jack, Flavio Nobili, Agneta Nordberg, Heather M Snyder, Mara Ten Kate, Andrea Varrone, Emiliano Albanese, Stefanie Becker, Patrick Bossuyt, Maria C Carrillo, Chiara Cerami, Bruno Dubois, Valentina Gallo, Ezio Giacobini, Gabriel Gold, Samia Hurst, Anders Lönneborg, Karl-Olof Lovblad, Niklas Mattsson, José-Luis Molinuevo, Andreas U Monsch, Urs Mosimann, Alessandro Padovani, Agnese Picco, Corinna Porteri, Osman Ratib, Laure Saint-Aubert, Charles Scerri, Philip Scheltens, Jonathan M Schott, Ida Sonni, Stefan Teipel, Paolo Vineis, Pieter Jelle Visser, Yutaka Yasui, Bengt Winblad
The diagnosis of Alzheimer's disease can be improved by the use of biological measures. Biomarkers of functional impairment, neuronal loss, and protein deposition that can be assessed by neuroimaging (ie, MRI and PET) or CSF analysis are increasingly being used to diagnose Alzheimer's disease in research studies and specialist clinical settings. However, the validation of the clinical usefulness of these biomarkers is incomplete, and that is hampering reimbursement for these tests by health insurance providers, their widespread clinical implementation, and improvements in quality of health care...
August 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28721913/clinical-utility-of-epstein-barr-virus-dna-testing-in-the-treatment-of-nasopharyngeal-carcinoma-patients
#11
REVIEW
Kelly Y Kim, Quynh-Thu Le, Sue S Yom, Raymond H W Ng, K C Allen Chan, Scott V Bratman, John J Welch, Rao L Divi, Raymond A Petryshyn, Barbara A Conley
Epstein-Barr virus (EBV) DNA analysis has been shown to be useful for early detection, prognostication, and monitoring of treatment response of nasopharyngeal carcinoma (NPC), and the recent literature provides growing evidence of the clinical utility of EBV DNA testing, particularly to inform treatment decisions for NPC patients. Despite the fact that NPC is a rare disease, the NRG Oncology cooperative group has successfully activated a phase 2/3 randomized clinical trial for NPC with international partners and in that process has discovered that the development of a harmonized EBV DNA test is absolutely critical for integration into clinical trials and for future deployment in clinical and central laboratories...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28721328/dramatic-regression-of-a-fungating-breast-lesion-treated-with-radiation-therapy
#12
Robert W Gao, Shane Edlund, Jianling Yuan
Although advances in screening mammography have dramatically improved the early detection of breast cancer, a subset of breast cancer cases still present as locally advanced disease. Some of these patients develop fungating lesions, which are difficult to manage and can have a severe impact on the quality of life. Palliative treatment options include surgery, intra-arterial chemotherapy, and radiation therapy. Herein, we describe the case of a patient who presented with a fungating breast mass and demonstrated an immediate and durable response to radiation therapy with a significantly improved quality of life...
June 16, 2017: Curēus
https://www.readbyqxmd.com/read/28721280/increasing-detection-of-significant-prostate-cancer-in-younger-men-ten-year-trends-in-prostate-cancer-risk-profile-in-the-mid-west-of-ireland
#13
Nikita R Bhatt, Tetyana Kelly, Kasia Domanska, Colette Fogarty, Garrett Durkan, Hugh D Flood, Subhasis K Giri
INTRODUCTION: Although PSA (prostate specific antigen) based screening for prostate cancer (PCa) is controversial, an increasing number of men are undergoing Transrectal Ultrasound Guided prostate biopsy (TRUSPB) through primary care-based PSA testing and referral to hospitals. The aim of our study was to investigate presenting risk profiles of PCa over the last decade in a cohort of men in Ireland and to examine any change in the same over this time period. MATERIAL AND METHODS: The hospital patient administration system was analysed for patients who underwent TRUSPB from January 2005 to December 2015...
June 30, 2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28721039/top-down-nanofabrication-of-silicon-nanoribbon-field-effect-transistor-si-nr-fet-for-carcinoembryonic-antigen-detection
#14
Zengtao Bao, Jialin Sun, Xiaoqian Zhao, Zengyao Li, Songkui Cui, Qingyang Meng, Ye Zhang, Tong Wang, Yanfeng Jiang
Sensitive and quantitative detection of tumor markers is highly required in the clinic for cancer diagnosis and consequent treatment. A field-effect transistor-based (FET-based) nanobiosensor emerges with characteristics of being label-free, real-time, having high sensitivity, and providing direct electrical readout for detection of biomarkers. In this paper, a top-down approach is proposed and implemented to fulfill a novel silicon nano-ribbon FET, which acts as biomarker sensor for future clinical application...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28720270/cancer-through-black-eyes-the-views-of-uk-based-black-men-towards-cancer-a-constructivist-grounded-theory-study
#15
Betselot Mulugeta, Susan Williamson, Rob Monks, Thomas Hack, Kinta Beaver
PURPOSE: Little is known about black African (BA) and black African-Caribbean (BAC) men's views towards cancer; yet culture and acculturation can contribute to the way in which people understand, explain and develop their attitudes towards cancer. Hence, cancer prevention and early detection strategies may not be sensitive to United Kingdom (UK)-based black men's views, affecting their awareness of risk factors and early detection services. This study explored the views of UK-based BA and BAC men towards cancer...
August 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28719864/in-vivo-magnetic-resonance-imaging-of-pancreatic-tumors-using-iron-oxide-nanoworms-targeted-with-ptr86-peptide
#16
Yasaman Ahmadi, Genady Kostenich, Mor Oron-Herman, Wolfgang Wadsak, Markus Mitterhauser, Arie Orenstein, Siroos Mirzaei, Peter Knoll
To cut the high mortality rate of malignant disease such as pancreatic cancer, development of newly diagnostic probes for early stage detection of tumor lesions is required. Multimodal imaging nanoprobes allowing targeted and real time functional/anatomical imaging of tumors meet the demands. For this purpose, a MRI/optical dual-modality probe based on biodegradable magnetic iron oxide nanoworms has been developed. The cross-linked surface of nanoworms were anchored to fluorescent dyes and to FITC.PTR86; a novel synthetic peptide with high affinity towards somatostatin receptors...
July 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28719381/detection-of-putative-stem-cell-markers-in-invasive-ductal-carcinoma-of-the-breast-by-immunohistochemistry-does-it-improve-prognostic-predictive-assessments
#17
Rodrigo V Oliveira, Valéria B Souza, Philipi C Souza, Fernando A Soares, José Vassallo, Rafael M Rocha, André A Schenka
INTRODUCTION: Experimental evidences from the last 2 decades supports the existence of a special type of neoplastic cell with stem-like features [cancer stem cell (CSC)] and their role in the pathophysiology and therapeutic resistance of breast cancer. However, their clinical value in human breast cancer has not been fully determined. MATERIALS AND METHODS: An immunohistochemistry panel of 10 putative CSC markers (CD34, C-KIT, CD10, SOX-2, OCT 3/4, p63, CD24, CD44, CD133, and ESA/EPCAM) was applied to 74 cases of breast cancer, followed in a Regional Cancer Center of Minas Gerais State, Brazil, from 2004 to 2006...
July 17, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28719348/trim59-is-a-key-regulator-of-growth-and-migration-inrenal-cell-carcinoma
#18
S-H Hu, M-J Zhao, W-X Wang, C-W Xu, G-D Wang
Renal cell carcinoma (RCC) is the most common renal neoplasms and metastatic is common. Previous data have shown that the tripartite motif (TRIM) family proteinswere implicated in human tumoriogenesis. In this study, we aimed to investigate the role of TRIM59 in the cell growth and migration in RCC. The expression of TRIM59 in human RCC tissues was initially examined by qRT-PCR. Alentivirus-based shRNA against TRIM59 (Lv-shTRIM59) was constructed. The effects of TRIM59 knockdown on cell proliferation were examined by in vitro MTT assay, colony formation assay and in vivo a mouse xenograft model of RCC...
May 20, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28719245/production-of-a-mouse-monoclonal-antibody-against-mortalin-by-whole-cell-immunization
#19
Marzieh Rezaei, Abbas Ghaderi
Pancreatic carcinoma is the fourth leading cause of cancer death and is characterized by early invasion and metastasis. Advances in molecular biology directed new strategies in targeted therapy using monoclonal antibodies. To identify new biomarkers, we generated a panel of monoclonal antibodies against the newly established cell line, Faraz-ICR, from a patient with acinar cell carcinoma. After immunization of BALB/c female mice with Faraz-ICR cell line and fusion of splenocytes with SP2/0 myeloma cell line, high reactive hybridoma producing antibodies to Faraz-ICR were detected using enzyme-linked immunosorbent assay, immunofluorescence staining and flow cytometry...
July 18, 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/28718432/autoantibodies-opportunities-for-early-cancer-detection
#20
REVIEW
Isabel K Macdonald, Celine B Parsy-Kowalska, Caroline J Chapman
Cancer cells can induce an immunological response resulting in the production of tumor-associated (TA) autoantibodies. These serum immunobiomarkers have been detected for a range of cancers at an early stage before the development of clinical symptoms. Their measurement is minimally invasive and cost effective using established technologies. TA autoantibodies are present in a clinically significant number of individuals and could supplement current screening modalities to aid early diagnosis of high-risk populations and assist the clinical management of patients...
March 2017: Trends in Cancer
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