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https://www.readbyqxmd.com/read/29909565/topical-pimecrolimus-versus-betamethasone-for-oral-lichen-planus-a-randomized-clinical-trial
#1
Ola M Ezzatt, Iman M Helmy
OBJECTIVES: Oral lichen plans (OLP) is a potentially malignant inflammatory mucocutaneous disease. CD133 is an investigated surface marker for cancer stem-like cells (CSCs) that may be involved in tumor initiation in head and neck carcinomas. We compared short-term clinical effectiveness of topical pimecrolimus as selective inflammatory cytokine release inhibitor with betamethasone cream for erosive/atrophic OLP and investigated the influence of this therapy on CD133 expression. MATERIAL AND METHODS: Thirty patients were randomly assigned into two equal groups to receive topical pimecrolimus (group I) or betamethasone (group II) four times daily for 4 weeks...
June 16, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29909007/early-emergence-of-de-novo-egfr-t790-m-gatekeeper-mutations-during-erlotinib-treatment-in-pc9-non-small-cell-lung-cancer-cells
#2
Sujin Kim, Angela Kj Park, Jeonghee Cho
The emergence of the T790 M gatekeeper mutation in the Epidermal Growth Factor Receptor (EGFR) gene is an important mechanism that can lead to the acquired resistance to EGFR-targeted tyrosine kinase inhibitors such as erlotinib or gefitinib. These drugs have been used in treating a subset of non-small cell lung cancer (NSCLC) patients harboring EGFR activating mutations. Here we investigated the paths leading to the acquisition of the T790 M mutation by establishing an erlotinib resistant PC9 cell model harboring ectopically introduced EGFR cDNA...
June 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29908282/the-function-and-clinical-significance-of-eif3-in-cancer
#3
REVIEW
Yuting Yin, Jiali Long, Yanqin Sun, Hongmei Li, Enping Jiang, Chao Zeng, Wei Zhu
Abnormal regulation of gene expression is essential for tumorigenesis. Several studies indicate that regulation of oncogene expression and neoplastic transformation are controlled by subunits of eukaryotic translation initiation factors (eIFs). Eukaryotic translation initiation factor 3 (eIF3) is the largest (800 kDa) and the most complex mammalian initiation factor. It is composed of 13 non-identical polypeptides designated as eIF3a-m and plays a pivotal role in protein synthesis that bridges the 43S pre-initiation complex and eIF4F-bound mRNA...
June 13, 2018: Gene
https://www.readbyqxmd.com/read/29907587/precision-prevention-and-early-detection-of-cancer-fundamental-principles
#4
Timothy R Rebbeck, Karen Burns-White, Andrew T Chan, Karen Emmons, Matthew Freedman, David J Hunter, Peter Kraft, Francine Laden, Lorelei Mucci, Giovanni Parmigiani, Deborah Schrag, Sapna Syngal, Rulla M Tamimi, Kasisomayajula Viswanath, Matthew B Yurgelun, Judy E Garber
Prevention and early detection is critical for reducing the population cancer burden. Two approaches have been used: Population approaches change social norms (e.g., smoking bans) or impose incentives (e.g., cigarette taxes); high-risk strategies intervene upon individuals with elevated cancer risk (e.g., smoking cessation). Knowledge about carcinogenesis mechanisms, extreme exposures, and inherited susceptibility provides opportunities to develop precision prevention and early-detection (PPED) strategies. PPED aims to understand the basis of risk, identify groups that optimally benefit from interventions, characterize heterogeneity in intervention responses, optimize intervention timing, and minimize toxicities...
June 15, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29907432/sensitivity-and-specificity-of-sentinel-lymph-node-biopsy-in-patients-with-oral-squamous-cell-carcinomas-using-indocyanine-green-fluorescence-imaging
#5
Ahmed Al-Dam, Clarissa Precht, Armelle Barbe, Carsten Kohlmeier, Henning Hanken, Johannes Wikner, Gerhard Schön, Max Heiland, Alexandre T Assaf
PURPOSE: The purpose of this clinical study was to evaluate the sensitivity and specificity of cervical sentinel lymph node biopsy after mapping with indocyanine green fluorescence (ICG) for imaging early-stage oral cancer. PATIENTS AND METHODS: A sentinel lymph node biopsy (SLNB) was performed during a selective neck dissection (SND) in 20 patients with oral squamous cell carcinoma (OSCC, cT1 or cT2, N0 status). The sentinel lymph nodes (SLN) were identified using an infrared video camera after ICG injection...
May 23, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29907291/bifunctional-aptamer-mediated-catalytic-hairpin-assembly-for-the-sensitive-and-homogenous-detection-of-rare-cancer-cells
#6
Jumei Liu, Ye Zhang, Qianwen Zhao, Bo Situ, Jiamin Zhao, Shihua Luo, Bo Li, Xiaohui Yan, Pankaj Vadgama, Lei Su, Wen Ma, Wen Wang, Lei Zheng
The presence of cancer cells in body fluids confirms the occurrence of metastasis and guides treatment. A simple, fast, and homogeneous fluorescent method was developed to detect cancer cells based on catalytic hairpin assembly (CHA) and bifunctional aptamers. The bifunctional aptamer had a recognition domain for binding to target cancer cells and an initiator domain for triggering the CHA reaction. In the presence of target cells, the bifunctional aptamer was released from the inhibitor and initiated a cascade reaction of assembly and disassembly of the hairpins...
October 31, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29907142/malbac-based-chromosomal-imbalance-analysis-a-novel-technique-enabling-effective-non-invasive-diagnosis-and-monitoring-of-bladder-cancer
#7
Hao Liu, Wang He, Bo Wang, Kewei Xu, Jinli Han, Junjiong Zheng, Jun Ren, Lin Shao, Shiping Bo, Sijia Lu, Tianxin Lin, Jian Huang
BACKGROUND: The gold standard for bladder cancer detection is cystoscopy, which is an invasive procedure that causes discomfort in patients. The currently available non-invasive approaches either show limited sensitivity in low-grade tumours or possess unsatisfying specificity. The aim of the present study is to develop a new non-invasive strategy based on chromosomal imbalance levels to detect bladder cancer effectively. METHODS: We enrolled 74 patients diagnosed with bladder cancer (BC), 51 healthy participants and 27 patients who were diagnosed with non-malignant urinary disease (UD)...
June 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29906408/the-potential-for-liquid-biopsies-in-head-and-neck-cancer
#8
Matthew E Spector, Janice L Farlow, Catherine T Haring, J Chad Brenner, Andrew C Birkeland
Head and neck cancers consist of a heterogeneous group of cancers that are difficult to treat successfully. Limited screening options result in patients being diagnosed at advanced stages at presentation, and difficulty with treatment options and post-treatment surveillance can lead to poor outcomes. In this setting, tools for early and precise detection of disease will be highly valuable. Liquid biopsies, or use of analytes in blood, saliva, and other body fluid samples, provide new avenues for cancer screening with the potential for early detection, treatment modification, and surveillance of head and neck cancers...
May 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29906025/malignant-tumors-as-cause-of-disability-at-the-instituto-mexicano-del-seguro-social
#9
Edgar Jesús Zitle-García, Alma Lucila Sauceda-Valenzuela, Iván de Jesús Ascencio-Montiel, Jesús García-Paredes
Background: Cancer represents an important issue in health, with the economic impact that it takes. The aim of this paper is to analyze the epidemiological characteristics of a population with social security who was diagnosed with some type of cancer and required a disability pension. Methods: Observational study, retrolective cohort type, carried out at the Instituto Mexicano del Seguro Social (IMSS) with IMSS beneficiaries ruled with a state of disability due to malignancy during the period 2006 to 2012...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29905981/alterations-in-desmosomal-adhesion-at-protein-and-ultrastructure-levels-during-the-sequential-progressive-grades-of-human-oral-tumorigenesis
#10
Sharada Sawant, Harsh Dongre, Chetan Ahire, Shilpi Sharma, Sayli Jamghare, Yashvi Kansara, Pallavi Rane, Deepak Kanojia, Asawari Patil, Devendra Chaukar, Sudeep Gupta, Anil D'Cruz, Milind Vaidya, Prabhakar Dongre
With the aim of developing early diagnostic/prognostic markers for oral cancer, desmosomal adhesion in sequentially progressive grades of tissues from oral normal/disorders (normal, hyperplastic, dysplastic, non-metastatic/metastatic tumours, and metastatic nodes) was investigated at protein and ultrastructural levels using immunohistochemistry and transmission electron microscopy, respectively. The expression of desmosomal proteins was higher in hyperplastic tissues than in normal tissues but was significantly decreased in subsequent progressive stages of the disease...
June 15, 2018: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29905920/breast-cancer-risk-evaluation-by-utilizing-gail-model-and-association-between-breast-cancer-risk-perception-with-early-diagnosis-applications-among-midwives-and-nurses-working-in-primary-health-services
#11
Ebru Turhan, Gokben Yasli
OBJECTIVE: The present study was performed to detect cancer risk of the midwifes and nurses playing central role in raising awareness in the society using Gail's model. MATERIALS AND METHODS: Sample of the present cross sectional study consists of 750 volunteer midwifes and nurses in 2016. Breast cancer risk was calculated using the Gail Risk Assessment Tool. Perceived and calculated risk levels were compared. Descriptive statistics and Chi-Square analysis, t-test, Multivariate Linear Regression Analysis, the Logistic Regression Analysis were conducted...
June 2018: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29905907/-68-ga-psma-11-pet-ct-in-prostate-cancer-patients-with-biochemical-recurrence-after-radical-prostatectomy-and-psa-0-5-ng-ml-efficacy-and-impact-on-treatment-strategy
#12
Andrea Farolfi, Francesco Ceci, Paolo Castellucci, Tiziano Graziani, Giambattista Siepe, Alessandro Lambertini, Riccardo Schiavina, Filippo Lodi, Alessio G Morganti, Stefano Fanti
PURPOSE: The primary aim of this retrospective, single-centre analysis was to assess the performance of 68 Ga-PSMA-11 PET/CT in prostate cancer (PCa) patients in early PSA failure after radical prostatectomy (RP). The secondary aim was to assess the potential impact of 68 Ga-PSMA-11 PET/CT on treatment strategy. METHODS: 68 Ga-PSMA-11 PET/CT is performed in our institution within an investigational new drug (IND) trial in PCa patients with biochemical recurrence (BCR)...
June 15, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29904241/microbial-markers-in-colorectal-cancer-detection-and-or-prognosis
#13
REVIEW
Romain Villéger, Amélie Lopès, Julie Veziant, Johan Gagnière, Nicolas Barnich, Elisabeth Billard, Delphine Boucher, Mathilde Bonnet
Colorectal cancer (CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure...
June 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29904176/cancer-prevention-by-aspirin-in-children-with-constitutional-mismatch-repair-deficiency-cmmrd
#14
REVIEW
Erika K S M Leenders, Harm Westdorp, Roger J Brüggemann, Jan Loeffen, Christian Kratz, John Burn, Nicoline Hoogerbrugge, Marjolijn C J Jongmans
Constitutional MisMatch Repair Deficiency (CMMRD) is caused by homozygous or compound heterozygous germline variants in one of the mismatch repair (MMR) genes (MSH2, MSH6, PMS2, MLH1). This syndrome results in early onset colorectal cancer, leukemia and lymphoma, brain tumors and other malignancies. Children with CMMRD are at high risk of developing multiple cancers and cancer surveillance does not guarantee detection of cancer at a curable stage. The development of a preventive treatment strategy would be a major step forward...
June 14, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29903741/in-vivo-multimodal-optical-imaging-improved-detection-of-oral-dysplasia-in-low-risk-oral-mucosal-lesions
#15
Eric C Yang, Richard A Schwarz, Alexander K Lang, Nancy E Bass, Hawraa Badaoui, Imran S Vohra, Katelin D Cherry, Michelle D Williams, Ann M Gillenwater, Nadarajah Vigneswaran, Rebecca Richards-Kortum
Early detection of oral cancer and oral premalignant lesions (OPLs) containing dysplasia could improve oral cancer outcomes. However, general dental practitioners have difficulty distinguishing dysplastic OPLs from confounder oral mucosal lesions in low-risk populations. We evaluated the ability of two optical imaging technologies, autofluorescence imaging (AFI) and high-resolution microendoscopy (HRME), to diagnose moderate dysplasia or worse (ModDys+) in 56 oral mucosal lesions in a low-risk patient population, using histopathology as the gold standard, and in 46 clinically normal sites...
June 14, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29903559/optical-coherence-tomography
#16
REVIEW
Rujuta A Katkar, Satyashankara Aditya Tadinada, Bennett T Amaechi, Daniel Fried
Optical coherence tomography (OCT) is a noninvasive diagnostic technique providing cross-sectional images of biologic structures based on the differences in tissue optical properties. OCT has been widely used in numerous clinical applications and is becoming popular as a promising technology in dentistry. Today, dental hard (tooth) and soft (hard palate mucosa and gingiva mucosa) tissues are visualized with OCT. With new developments in technology, the applications of OCT are being investigated in various fields in dentistry, such as to detect microleakage around restoration, tooth cracks/fractures, examination of periodontal tissues/pockets, early detection of oral cancerous tissues, and in endodontics for location of pulp canal...
July 2018: Dental Clinics of North America
https://www.readbyqxmd.com/read/29903461/decreased-expression-of-serine-protease-inhibitor-family-g1-serping1-in-prostate-cancer-can-help-distinguish-high-risk-prostate-cancer-and-predicts-malignant-progression
#17
Shengmeng Peng, Tao Du, Wanhua Wu, Xianju Chen, Yiming Lai, Dingjun Zhu, Qiong Wang, Xiaoming Ma, Chunhao Lin, Zean Li, Zhenghui Guo, Hai Huang
PURPOSE: The aim of this study was to investigate the associations of serine proteinase inhibitor family G1 (SERPING1) down-regulation with poor prognosis in patients with prostate cancer (PCa). Furthermore, we aim to find more novel and effective PCa molecular markers to provide an early screening of PCa, distinguish patients with aggressive PCa, predict the prognosis, or reduce the economic burden of PCa. METHODS: SERPING1 protein expression in both human PCa and normal prostate tissues was detected by immunohistochemical staining, which intensity was analyzed in association with clinical pathological parameters such Gleason score, pathological grade, clinical stage, tumor stage, lymph node metastasis, and distant metastasis...
June 11, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29902383/review-of-recent-efforts-to-discover-biomarkers-for-early-detection-monitoring-prognosis-and-prediction-of-treatment-responses-of-patients-with-gastric-cancer
#18
Koichi Sawaki, Mitsuro Kanda, Yasuhiro Kodera
Gastric cancer (GC) is the leading cause of cancer-related death worldwide. Despite recent advances in diagnosis and therapy, the prognosis of patients with GC is poor. Many patients have inoperable disease upon diagnosis or experience recurrent disease after curative gastrectomy. Unfortunately, tumor markers for GC, such as serum carcinoembryonic antigen and carbohydrate antigen 19-9, lack sufficient sensitivity and specificity. Therefore, effective biomarkers are required to detect early GC and to predict tumor recurrence and chemosensitivity...
June 14, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29902261/pik3ca-copy-number-aberration-and-activation-of-the-pi3k-akt-mtor-pathway-in-varied-disease-states-of-penile-cancer
#19
Anthony Adimonye, Elzbieta Stankiewicz, Susannah La-Touche, Sakunthala Kudahetti, Giorgia Trevisan, Brendan Tinwell, Cathy Corbishley, Yong-Jie Lu, Nick Watkin, Daniel Berney
BACKGROUND: Therapeutic targeting of the PI3K-AKT-mTOR pathway may benefit patients with advanced penile squamous cell carcinoma (PSCC). OBJECTIVES: To determine the prevalence of PIK3CA copy number gain and correlate this with the activity status of PI3K-AKT-mTOR pathway in pre-malignant penile intraepithelial neoplasia (PeIN) and invasive PSCC. MATERIALS AND METHODS: Archival tissue blocks were obtained from 58 PeIN and 244 primary PSCC patients treated at St George's Hospital...
2018: PloS One
https://www.readbyqxmd.com/read/29901188/differences-in-the-expression-profiles-of-claudin-proteins-in-human-gastric-carcinoma-compared-with-non%C3%A2-neoplastic-mucosa
#20
Luoluo Yang, Xun Sun, Xiangwei Meng
Numerous genetic alterations associated with cancer progression have the potential to serve as biomarkers for the early diagnosis of cancer. Numerous studies have suggested that claudin proteins, which are the primary components of tight junction structures, are associated with the regulation of cell polarity and cell differentiation. To investigate the expression profiles of the tight junction proteins claudin‑2, ‑5, ‑7 and ‑8 in gastric carcinoma, immunohistochemical analysis, western blotting and reverse transcription‑quantitative polymerase chain reaction analysis was used to detect the expression profiles of these claudin proteins in gastric carcinoma tissues and in homologous non‑neoplastic mucosal tissues...
June 1, 2018: Molecular Medicine Reports
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