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https://www.readbyqxmd.com/read/29679553/potential-diagnostic-role-of-circulating-mirnas-in-breast-cancer-implications-on-clinicopathological-characters
#1
Menha Swellam, Hekmat M El Magdoub, Naglaa M Hassan, Mona M Hefny, Mohamed Emam Sobeih
BACKGROUND: Circulating miRNAs are stable in body fluids and resembles their levels in cancer tissue/cells. They have been expressed in many cancers among them is breast cancer. Authors aimed to investigate the expression level of three circulating oncomiRNAs (miRNA-21, miRNA-222 and miRNA-373) in serum samples as a minimally non-invasive method for early detection of breast cancer, and study their relation with clinicopathological characters. METHODS: MiRNAs expression levels were determined using quantitative real-time polymerase chain reaction (qPCR) in serum samples from three groups: primary breast cancer patients (n = 137), benign breast lesion patients (n = 60), and healthy individuals as control group (n = 38)...
April 18, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29679420/a-dual-label-time-resolved-fluorescence-immunoassay-for-the-simultaneous-determination-of-carcino-embryonic-antigen-and-squamous-cell-carcinoma-antigen
#2
Qian Mao, Xiaohong Liu, Jingwen Ye, Huankun Liang, Binxian Li, Xinyi Sun, Lin Sun, Yuman Sun, Xiaomei Mu, Laiqing Li
Among women worldwide, cervical cancer is the second-most common cancer, and cervical smears and DNA detection have low sensitivity or are too expensive. The concentrations of carcino-embryonic antigen (CEA) and squamous cell carcinoma (SCC) in the serum were detected using a sandwich immunoassay. The CEA and SCC in the serum were captured by anti-CEA and anti-SCC antibodies. After combining other anti-CEA- and anti-SCC-labeled antibodies with europium (III) (Eu3+ ) and samarium (III) (Sm3+ ) chelates, CEA and SCC were detected with time-resolved fluorometry (TRF)...
April 20, 2018: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/29678902/development-of-a-breast-cancer-risk-prediction-model-for-women-in-nigeria
#3
Shengfeng Wang, Temidayo O Ogundiran, Adeyinka Ademola, Olayiwola A Oluwasola, Adewunmi O Adeoye, Adenike Sofoluwe, Imran Morhason-Bello, Stella O Odedina, Imaria Agwai, Clement Adebamowo, Millicent Obajimi, Oladosu Ojengbede, Olufunmilayo I Olopade, Dezheng Huo
BACKGROUND: Risk prediction models have been widely used to identify women at higher risk of breast cancer. We aim to develop a model for absolute breast cancer risk prediction for Nigerian women. METHODS: A total of 1,811 breast cancer cases and 2,225 controls from the Nigerian Breast Cancer Study (NBCS, 1998~2015) were included. Subjects were randomly divided into the training and validation sets. Incorporating local incidence rates, multivariable logistic regressions were used to develop the model...
April 20, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29678787/cd44-directed-nanomicellar-payload-delivery-platform-for-selective-anticancer-effect-and-tumor-specific-imaging-of-triple-negative-breast-cancer
#4
Zhaoxian Wang, Samaresh Sau, Hashem O Alsaab, Arun K Iyer
Triple negative breast cancer (TNBC) is a highly aggressive tumor subtype, lacking estrogen, progesterone and human epidermal growth factor-2 (HER-2) receptors. Thus, early detection and targeted therapy of TNBC is an urgent need. Herein, we have developed a CD44 targeting Hyaluronic Acid (HA) decorated biocompatible oligomer, containing FDA approved vitamin E TPGS and Styrene Maleic Anhydride (SMA) (HA-SMA-TPGS) for targeting TNBC. The self-assembling HA-SMA-TPGS was encapsulated with poorly water soluble, potent curcumin analogue (CDF) to form nanomicelles (NM), HA-SMA-TPGS-CDF has demonstrated excellent nanoparticle charateristics for parenteral delivery...
April 17, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29675469/noninvasive-ovarian-cancer-biomarker-detection-via-an-optical-nanosensor-implant
#5
Ryan M Williams, Christopher Lee, Thomas V Galassi, Jackson D Harvey, Rachel Leicher, Maria Sirenko, Madeline A Dorso, Janki Shah, Narciso Olvera, Fanny Dao, Douglas A Levine, Daniel A Heller
Patients with high-grade serous ovarian carcinoma (HGSC) exhibit poor 5-year survival rates, which may be significantly improved by early-stage detection. The U.S. Food and Drug Administration-approved biomarkers for HGSC-CA-125 (cancer antigen 125) and HE4 (human epididymis protein 4)-do not generally appear at detectable levels in the serum until advanced stages of the disease. An implantable device placed proximal to disease sites, such as in or near the fallopian tube, ovary, uterine cavity, or peritoneal cavity, may constitute a feasible strategy to improve detection of HGSC...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29675249/ultrasensitive-and-specific-fluorescence-detection-of-a-cancer-biomarker-via-nanomolar-binding-to-a-guanidinium-modified-calixarene
#6
Zhe Zheng, Wen-Chao Geng, Jie Gao, Yu-Ying Wang, Hongwei Sun, Dong-Sheng Guo
We designed a water-soluble guanidinium-modified calix[5]arene to target lysophosphatidic acid (LPA), an ideal biomarker for early diagnosis of ovarian and other gynecologic cancers, achieving binding on the nanomolar level. An indicator displacement assay, coupled with differential sensing, enabled ultrasensitive and specific detection of LPA. Moreover, we show that using a calibration line, the LPA concentration in untreated serum can be quantified in the biologically relevant low μM range with a detection limit of 1...
February 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29675182/a-novel-restriction-endonuclease-glai-for-rapid-and-highly-sensitive-detection-of-dna-methylation-coupled-with-isothermal-exponential-amplification-reaction
#7
Yueying Sun, Yuanyuan Sun, Weimin Tian, Chenghui Liu, Kejian Gao, Zhengping Li
Sensitive and accurate detection of site-specific DNA methylation is of critical significance for early diagnosis of human diseases, especially cancers. Herein, for the first time we employ a novel methylation-dependent restriction endonuclease GlaI to detect site-specific DNA methylation in a highly specific and sensitive way by coupling with isothermal exponential amplification reaction (EXPAR). GlaI can only cut the methylated target site with excellent selectivity but leave the unmethylated DNA intact. Then the newly exposed end fragments of methylated DNA can trigger EXPAR for highly efficient signal amplification while the intact unmethylated DNA will not initiate EXPAR at all...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29675180/single-quantum-dot-based-nanosensor-for-sensitive-detection-of-5-methylcytosine-at-both-cpg-and-non-cpg-sites
#8
Zi-Yue Wang, Li-Juan Wang, Qianyi Zhang, Bo Tang, Chun-Yang Zhang
DNA methylation is an important epigenetic modification in human genomes. Herein, we develop a single quantum dot (QD)-based nanosensor for sensitive detection of DNA methylation at both CpG and non-CpG sites using tricyclic ligation chain reaction (LCR)-mediated QD-based fluorescence resonance energy transfer (FRET). We design two sets of DNA probes (X and Y, X' and Y') for methylated DNA assay. In the presence of thermostable DNA ligase, probes X and Y may adjacently hybridize with the methylated DNA to obtain the ligated XY products which may function as the templates for probes X' and Y' to generate the X'Y' products...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29675163/imaging-multiple-micrornas-in-living-cells-using-atp-self-powered-strand-displacement-cascade-amplification
#9
Xiangdan Meng, Wenhao Dai, Kai Zhang, Haifeng Dong, Xueji Zhang
Herein, we design a smart autonomous ATP self-powered strand-displacement cascade amplification (SDCA) system for highly sensitive multiple intracellular miRNA detection. Rationally engineered Y-motif DNA structures are functionalized on mesoporous silica-coated copper sulfide nanoparticles loaded with numerous ATPs (CuS@mSiO2 -Y/ATP) through pH stimulus-responsive disulfide bonds. The SDCA system is implemented by endogenous specific miRNA as a trigger and ATP as fuel released from the nanocarrier at acidic pH and photothermal stimuli-responsive CuS...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29673364/colorectal-dysplasia-and-adenocarcinoma-in-patients-with-ulcerative-colitis-an-experience-from-a-tertiary-care-hospital
#10
Naila Younus, Mariam Abid, Atif Ali Hashmi, Saher Aijaz, Muhammad Muzzammil Edhi, Ahmareen Khalid Sheikh, Amir Khan
BACKGROUND: The rationale behind this study was to find out the frequency of dysplasia and colorectal cancer (CRC) in young patients with ulcerative colitis (UC) using histopathological examination. This facilitated early detection of dysplasia and CRC by regular endoscopic biopsies and also guided physicians on appropriate surveillance and management, thus improved outcome. METHODS: It was a prospective cross-sectional study conducted at the Department of Pathology, PIMS, Islamabad...
April 19, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29673015/analysis-of-246-sentinel-lymph-node-biopsies-of-patients-with-clinical-primary-breast-cancer-by-application-of-carbon-nanoparticle-suspension
#11
Shi-Xin Yang, Wen-Song Wei, Qi-Hua Jiang, Yu-Feng Zhou, Wei Qu, Jian-Hong Tu, Qian-Wen Ou-Yang, Zhi-Bing Zhou, Hao-Long Ding, Chun-Wei Xie
AIM: This study aims to explore the accuracy, specificity and laws of axillary lymph node metastasis predicted by sentinel lymph node biopsy (SLNB) by comparing axillary lymph node status via SLNB and axillary lymph node dissection (ALND) with nanocarbon as the tracer. METHODS: Forty six patients were retrospectively analyzed. These patients underwent SLNB with nanocarbon as the tracer from March 2013 to April 2014. RESULTS: Two hundred and forty six patients of sentinel lymph node (SLN) were successfully detected...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29672847/loss-of-n-wasp-drives-early-progression-in-an-apc-model-of-intestinal-tumourigenesis
#12
Hayley T Morris, Loic Fort, Heather J Spence, Rachana Patel, David F Vincent, James H Park, Scott B Snapper, Francis A Carey, Owen J Sansom, Laura M Machesky
N-WASP (WASL) is a widely expressed cytoskeletal signalling and scaffold protein also implicated in regulation of Wnt signalling and homeostatic maintenance of skin epithelial architecture. N-WASP mediates invasion of cancer cells in vitro and its depletion reduces invasion and metastatic dissemination of breast cancer. Given this role in cancer invasion and universal expression in the gastrointestinal tract, we explored a role for N-WASP in the initiation and progression of colorectal cancer. While deletion of N-wasp is not detectably harmful in the murine intestinal tract, numbers of Paneth cells increased, indicating potential changes in the stem cell niche and migration up the crypt-villus axis was enhanced...
April 19, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29671552/cervical-cancer-evaluation-and-management
#13
Jennifer Wipperman, Tara Neil, Tracy Williams
Human papillomavirus infection is the precursor for the development of cervical cancer and is detectable in 99.7% of squamous cell carcinoma and adenocarcinoma cases. Early detection of precancerous lesions with Papanicolaou testing remains the primary mechanism for cancer prevention. Once cervical cancer is diagnosed, treatment may involve surgery, radiation therapy, chemotherapy, or a combination. The choice of therapy depends on the stage of disease, lymph node involvement, patient comorbidities, and risk factors for recurrence...
April 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29671079/-practice-of-early-detection-of-prostate-cancer-descriptive-survey-in-preparation-for-the-psainform-study
#14
A Simbrich, A Semjonow, N Donner-Banzhoff, H-W Hense
BACKGROUND: The randomized controlled PSAInForm study aims to investigate the effects of a computer-based decision aid which informs men in the age group 55-69 years about advantages and disadvantages of PSA testing. In preparation for the study, the current PSA testing practice in the Münster district was assessed. MATERIALS AND METHODS: The frequencies of early detection examinations, medically indicated PSA tests, and prostate biopsies in the Münster district were determined, using aggregated data from the regional association of Statutory Health Insurance (SHI) Physicians in Westfalen-Lippe...
April 18, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29670473/determination-of-the-reference-values-of-the-tumor-marker-he4-in-female-population-of-canton-sarajevo
#15
Lejla Hasanbegovic, Nedeljka Sljivo
Introduction: Ovarian cancer has the highest mortality rate of all gynecological tumors and represent fifth leading cause of cancer death in women, due to the absence of early symptoms of the disease and the lack of screening tests. A new HE4 ovarian cancer biomarker was found in various studies, with different populations having quite different sensitivity and specificity values as well as reference values. The tumor marker HE4 is a useful marker for ovarian cancer detection with only minimal expression in normal ovarian tissue...
March 2018: Materia Socio-medica
https://www.readbyqxmd.com/read/29670377/crocin-induces-autophagic-apoptosis-in-hepatocellular-carcinoma-by-inhibiting-akt-mtor-activity
#16
Chong Yao, Bing-Bing Liu, Xiao-Dong Qian, Li-Qin Li, Heng-Bin Cao, Qiao-Sheng Guo, Gui-Fen Zhou
Background: Autophagy induction is a common mechanism for antitumor chemicals in induction of cancer cell death. However, the role of autophagy in crocin-induced apoptosis is barely studied in hepatocellular carcinoma (HCC). Materials and methods: The influence of crocin on growth, apoptosis, and autophagy and its mutual relations were analyzed by Cell Counting Kit-8 assay, flow cytometer, EGFP-LC3 puncta analysis, and Western blot in HCC cells. The activities of Akt/mTOR axis and its roles in autophagy regulation were also detected by Western blot in HCC cells treated with crocin...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29670364/-99m-tc-labeled-sodium-phytate-and-stannous-chloride-injection-accurately-detects-sentinel-lymph-node-in-axillary-of-early-stage-breast-cancer-a-randomized-controlled-study
#17
Suisheng Yang, Weiyu Bao, Xiaorong Bai, Chen Gao, Binming Zhang, Zhuanji Jiang
Aim: The aim of this study was to assess the sentinel lymph node (SLN) detection rate and accuracy of 99m Tc-labeled sodium phytate and stannous chloride (99m Tc-PHY) injection versus 99m Tc-labeled sulfur colloid (99m Tc-SC) injection in sentinel lymph node biopsy (SLNB) in patients with early stage breast cancer. Methods: A total of 146 consecutive female patients with early stage breast cancer were recruited in this open-labeled, randomized, controlled study...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29670060/innovative-diagnostic-methods-for-early-prostate-cancer-detection-through-urine-analysis-a-review
#18
REVIEW
Carmen Bax, Gianluigi Taverna, Lidia Eusebio, Selena Sironi, Fabio Grizzi, Giorgio Guazzoni, Laura Capelli
Prostate cancer is the second most common cause of cancer death among men. It is an asymptomatic and slow growing tumour, which starts occurring in young men, but can be detected only around the age of 40–50. Although its long latency period and potential curability make prostate cancer a perfect candidate for screening programs, the current procedure lacks in specificity. Researchers are rising to the challenge of developing innovative tools able of detecting the disease during its early stage that is the most curable...
April 18, 2018: Cancers
https://www.readbyqxmd.com/read/29668599/which-is-better-for-predicting-pelvic-lymph-node-metastases-in-patients-with-cervical-cancer-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-or-a-sentinel-node-biopsy-a-retrospective-observational-study
#19
Tomohito Tanaka, Shun Sasaki, Hiromitsu Tsuchihashi, Yoshito Terai, Kazuhiro Yamamoto, Takashi Yamada, Masahide Ohmichi
Systematic pelvic lymph node resection may not be needed for patients with cervical cancer, especially in the early stage, if the pre- or intraoperative diagnosis of lymph node status is correct. The aim of this study was to evaluate the diagnostic accuracy of pelvic lymph node metastasis for fluorodeoxyglucose-positron emission tomography/computed tomography (FDG PET/CT) and sentinel node biopsy (SNB) of cervical cancer patients.Forty-eight patients with cervical cancer were imaged with FDG PET/CT before radical hysterectomy and underwent an SNB followed by systematic pelvic lymph node dissection...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668594/f-18-fdg-pet-ct-and-mri-for-detecting-the-malignant-potential-in-patients-with-gastrointestinal-stromal-tumors-a-protocol-for-a-network-meta-analysis-of-diagnostic-test-accuracy
#20
Kongyuan Wei, Bei Pan, Huan Yang, Cuncun Lu, Long Ge, Nong Cao
BACKGROUND: Gastrointestinal stromal tumor (GIST) is a rare cancer in gastrointestinal carcinomas and has been widely known as a curable disease among all the digestive tumors. However, early detection of malignant potential in patients with GIST has still been a huge challenge all around the world. CT, MRI, and F-18 FDG PET are all considered as good tests for diagnosing malignant GIST efficiently, but no recommended suggestions presents which test among the 3 is the prior one in detecting the malignant potential of GIST...
April 2018: Medicine (Baltimore)
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