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https://www.readbyqxmd.com/read/28227812/the-development-of-real-time-pcr-micro-device-with-optical-sensor-for-early-detection-of-cancer
#1
Yusuke Kimura, Keigo Osada, Yoshinori Inoue, Masashi Ikeuchi, Koji Ikuta, Yusuke Kimura, Keigo Osada, Yoshinori Inoue, Masashi Ikeuchi, Koji Ikuta, Koji Ikuta, Yoshinori Inoue, Keigo Osada, Yusuke Kimura, Masashi Ikeuchi
We can detect cancer in the early stages by validating the expression of cancer specific nucleic acids in the blood. In this report, we have developed the micro device for performing real-time polymerase chain reaction (real-time PCR), one of the methods used for determining the quantity of nucleic acids, using a small volume of reagent. This all-in-one device can perform real-time PCR with the inclusion of heating control and the analyzing system with optical sensor.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227373/comparative-study-of-texture-features-in-oct-images-at-different-scales-for-human-breast-tissue-classification
#2
Yu Gan, Xinwen Yao, Ernest Chang, Syed Bin Amir, Hanina Hibshoosh, Sheldon Feldman, Christine P Hendon, Yu Gan, Xinwen Yao, Ernest Chang, Syed Bin Amir, Hanina Hibshoosh, Sheldon Feldman, Christine P Hendon, Syed Bin Amir, Christine P Hendon, Sheldon Feldman, Yu Gan, Hanina Hibshoosh, Ernest Chang, Xinwen Yao
Breast cancer is the second leading cause of death in women in the United States due to cancer. Early detection of breast cancerous regions will aid the diagnosis, staging, and treatment of breast cancer. Optical coherence tomography (OCT), a non-invasive imaging modality with high resolution, has been widely used to visualize various tissue types within the human breast and has demonstrated great potential for assessing tumor margins. Imaging large resected samples with a fast imaging speed can be accomplished by under-sampling in the spatial domain, resulting in a large image scale...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226760/a-new-approach-of-oral-cancer-detection-using-bilateral-texture-features-in-digital-infrared-thermal-images
#3
M Chakraborty, S Mukhopadhyay, A Dasgupta, S Patsa, N Anjum, J G Ray, M Chakraborty, S Mukhopadhyay, A Dasgupta, S Patsa, N Anjum, J G Ray, S Patsa, A Dasgupta, N Anjum, M Chakraborty, S Mukhopadhyay, J G Ray
Oral cancer is one of the most prevalent form of cancer and its severity is aggrandized specially among the socio-economically backward population in developing countries. A major fraction of patient population is unable to avail diagnosis for oral cancer due to scarcity of state-of-the-art infrastructure and experienced oral and maxillofacial pathologist. Contemporary gold standard of oral cancer confirmation relies on biopsy report. But biopsy is invasive and thus patients are usually reluctant to undergo this test...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226759/melanoma-detection-by-analysis-of-clinical-images-using-convolutional-neural-network
#4
E Nasr-Esfahani, S Samavi, N Karimi, S M R Soroushmehr, M H Jafari, K Ward, K Najarian, E Nasr-Esfahani, S Samavi, N Karimi, S M R Soroushmehr, M H Jafari, K Ward, K Najarian, M H Jafari, S M R Soroushmehr, E Nasr-Esfahani, S Samavi, K Najarian, N Karimi, K Ward
Melanoma, most threatening type of skin cancer, is on the rise. In this paper an implementation of a deep-learning system on a computer server, equipped with graphic processing unit (GPU), is proposed for detection of melanoma lesions. Clinical (non-dermoscopic) images are used in the proposed system, which could assist a dermatologist in early diagnosis of this type of skin cancer. In the proposed system, input clinical images, which could contain illumination and noise effects, are preprocessed in order to reduce such artifacts...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226755/automatic-detection-of-melanoma-using-broad-extraction-of-features-from-digital-images
#5
M H Jafari, S Samavi, N Karimi, S M R Soroushmehr, K Ward, K Najarian, M H Jafari, S Samavi, N Karimi, S M R Soroushmehr, K Ward, K Najarian, K Ward, M H Jafari, S M R Soroushmehr, S Samavi, K Najarian, N Karimi
Automatic and reliable diagnosis of skin cancer, as a smartphone application, is of great interest. Among different types of skin cancers, melanoma is the most dangerous one which causes most deaths. Meanwhile, melanoma is curable if it were diagnosed in its early stages. In this paper we propose an efficient system for prescreening of pigmented skin lesions for malignancy using general-purpose digital cameras. These images can be captured by a smartphone or a digital camera. This could be beneficial in different applications, such as computer aided diagnosis and telemedicine applications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226683/preliminary-imaging-results-and-sar-analysis-of-a-microwave-imaging-system-for-early-breast-cancer-detection
#6
Ashkan Ghanbarzadeh Dagheyan, Ali Molaei, Richard Obermeier, Jose Martinez-Lorenzo, Ashkan Ghanbarzadeh Dagheyan, Ali Molaei, Richard Obermeier, Jose Martinez-Lorenzo, Ali Molaei, Ashkan Ghanbarzadeh Dagheyan, Jose Martinez-Lorenzo, Richard Obermeier
Currently X-ray-based imaging systems suffer from low contrast between malignant and healthy fibrous tissues in breast. Microwave Near-field Radar Imaging (NRI) shows a higher contrast between the aforementioned tissues and therefore can enhance tumor detection and diagnosis accuracy. In this work, we present the first imaging results of our developed NRI system that is equipped with a pair of Antipodal Vivaldi Antennas. We used a metal bearing ball immersed in oil as our object of interest, to keep the first measurement configuration simple...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226681/thermal-analysis-of-multiple-antenna-excited-breast-model-for-breast-cancer-detection
#7
Yinan Li, Babak Fahimi, Yinan Li, Babak Fahimi, Babak Fahimi, Yinan Li
Infrared thermography (IRT), or thermal imaging has long been proposed as a novel method in early detection of breast cancer. Most of the work done was through the detection of abnormal hotspot, or asymmetries in a thermal texture map. However, the surface temperature may not appear symmetric even for a healthy breast because of variations in blood supply and individual differences. In this paper, a method that is independent of the aforementioned symmetry is proposed. The breast under detection is initially excited by a group of patch antennas...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224081/rna-seq-analysis-of-human-cell-lines-established-from-normal-and-neoplastic-esophageal-squamous-epithelium
#8
Ichiro Akagi, Osamu Ishibashi
Esophageal cancer (EC) is the eighth most common cancer globally in 2012 and predominantly occurs in the man (Enzinger and Mayer, 2003; Conteduca et al., 2012). EC is classified mainly into two types, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma, accounting for 60-70% and 20-30% of all EC cases, respectively. In a previous statistical study it was reported that the numbers of new EC cases and EC-related deaths worldwide in 2008 were estimated to be 482,300 and 406,800, respectively (Jemal et al...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28223720/is-endoscopic-ultrasound-examination-necessary-in-the-management-of-esophageal-cancer
#9
REVIEW
Tomas DaVee, Jaffer A Ajani, Jeffrey H Lee
Despite substantial efforts at early diagnosis, accurate staging and advanced treatments, esophageal cancer (EC) continues to be an ominous disease worldwide. Risk factors for esophageal carcinomas include obesity, gastroesophageal reflux disease, hard-alcohol use and tobacco smoking. Five-year survival rates have improved from 5% to 20% since the 1970s, the result of advances in diagnostic staging and treatment. As the most sensitive test for locoregional staging of EC, endoscopic ultrasound (EUS) influences the development of an optimal oncologic treatment plan for a significant minority of patients with early cancers, which appropriately balances the risks and benefits of surgery, chemotherapy and radiation...
February 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28223670/-clinical-management-of-hboc-in-our-hospital
#10
Hidetaka Nomura, Nobuhiro Takeshima
The cumulative risks of developing epithelial ovarian cancer in women aged 70-75years with BRCA1 and BRCA2 germline mutations are approximately 39-40% and 11-18%, respectively. Here, we present the management of hereditary breast and ovarian cancer(HBOC)in our hospital. HBOC management commences with the selection of appropriate candidates for genetic testing, based on personal and familial characteristics that determine the individual's probability of being a mutation carrier. Pre-test counseling, which is an essential element of genetic counseling, should include discussion of why the test is being offered, how the test results may affect medical management, and the cancer risks associated with the gene mutation...
February 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28223433/global-cancer-in-women-burden-and-trends
#11
Lindsey A Torre, Farhad Islami, Rebecca L Siegel, Elizabeth M Ward, Ahmedin Jemal
There are striking disparities in the global cancer burden in women, yet few publications highlight cancer occurrence in this population, particularly for cancers that are not sex-specific. This paper, the first in a series of two, summarizes the current burden, trends, risk factors, prevention, early detection, and survivorship of all cancers combined and seven sites (breast, cervix, uterine corpus, ovary, colorectum, lung, and liver) that account for about 60% of the cancer burden among women worldwide, using data from the International Agency for Research on Cancer...
February 21, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28223153/evaluations-of-implementation-at-early-adopting-lung-cancer-screening-programs-lessons-learned
#12
Yaron B Gesthalter, Elisa Koppelman, Rendelle Bolton, Christopher G Slatore, Sue H Yoon, Hilary C Cain, Nichole T Tanner, David H Au, Jack A Clark, Renda Soylemez Wiener
BACKGROUND: Guidelines recommend lung cancer screening and it is currently being adopted nationwide. The American College of Chest Physicians advises inclusion of specific programmatic components to ensure high-quality screening. However, little is known about how lung cancer screening has been implemented in practice. We sought to evaluate the experience of early-adopting programs, characterize barriers faced, and identify strategies to achieve successful implementation. METHODS: We performed qualitative evaluations of lung cancer screening implementation at three Veterans Health Administration facilities, conducting semi-structured interviews with key staff (n=29)...
February 18, 2017: Chest
https://www.readbyqxmd.com/read/28222889/pre-cancer-risk-assessment-in-habitual-smokers-from-dic-images-of-oral-exfoliative-cells-using-active-contour-and-svm-analysis
#13
Susmita Dey, Ripon Sarkar, Kabita Chatterjee, Pallab Datta, Ananya Barui, Santi P Maity
Habitual smokers are known to be at higher risk for developing oral cancer, which is increasing at an alarming rate globally. Conventionally, oral cancer is associated with high mortality rates, although recent reports show the improved survival outcomes by early diagnosis of disease. An effective prediction system which will enable to identify the probability of cancer development amongst the habitual smokers, is thus expected to benefit sizable number of populations. Present work describes a non-invasive, integrated method for early detection of cellular abnormalities based on analysis of different cyto-morphological features of exfoliative oral epithelial cells...
February 9, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28221716/ionic-self-assembled-platform-of-perylenediimide-sodium-dodecylsulfate-for-detection-of-spermine-in-clinical-samples
#14
Prabhpreet Singh, Lalit Singh Mittal, Gaurav Bhargava, Subodh Kumar
The detection and quantification of spermine in clinical practice is important for early diagnosis of many diseases. The chromatographic and immunoassay-based methods are commonly used. However, fluorescence-based assay could provide real time detection. Herein, we report synthesis and aggregation properties of dicationic perylene probe (DAB-PDI) and used DAB-PDI in developing fluorescent 'turn-on' ensemble for detection of spermine. The fluorescence of DAB-PDI (10 µM, Φ = 0.55) is efficiently quenched by negatively charged sodium dodecylsulfate (SDS) through formation of ionic self-assembled aggregates (charge ratio N/P = 9)...
February 21, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28221220/impact-of-the-united-states-preventive-services-task-force-d-recommendation-on-prostate-cancer-screening-and-staging
#15
Renu S Eapen, Annika Herlemann, Samuel L Washington, Matthew R Cooperberg
PURPOSE OF REVIEW: In 2012, the United States Preventive Services Task Force (USPSTF) issued a grade 'D' recommendation against the use of routine prostate-specific antigen (PSA)-based screening for any men. This recommendation reflects critical misinterpretations of the available evidence base regarding benefits and harms of PSA screening and has influenced the nationwide landscape of prostate cancer screening, diagnosis, and treatment. RECENT FINDINGS: Following the USPSTF recommendation, a substantial decline in PSA screening was noted for all age groups...
February 17, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28221219/improving-the-evaluation-and-diagnosis-of-clinically-significant-prostate-cancer-in-2017
#16
Sigrid V Carlsson, Monique J Roobol
PURPOSE OF REVIEW: To provide an overview of the current state of the evidence and highlight recent advances in the evaluation and diagnosis of clinically significant prostate cancer, focusing on biomarkers, risk calculators and multiparametric MRI (mpMRI). RECENT FINDINGS: In 2017 there are numerous options to improve early detection as compared to a purely prostate-specific antigen (PSA)-based approach. All have strengths and drawbacks. In addition to repeating the PSA and performing clinical work-up (digital rectal examination and estimation of prostate volume), additional tests investigated in the initial biopsy setting are: %free PSA, Prostate Health Index, 4-kallikrein score, SelectMDx, and Michigan Prostate Score and in the repeat setting: %free PSA, Prostate Health Index, 4-kallikrein score, Prostate Cancer Antigen 3, and ConfirmMDx...
February 17, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28221216/l1cam-and-her2-expression-in-early-endometrioid-uterine-cancer
#17
Samira Abdel Azim, Susanne Sprung, Irene Mutz-Dehbalaie, Siegfried Fessler, Alain G Zeimet, Christian Marth
Recently L1CAM was shown to be a promising biomarker for early-stage endometrial carcinoma (EC). As L1CAM expression was found to be related to serous ECs and areas of serous differentiation in endometrioid carcinomas, there is evidence that L1CAM-positive cancers more likely resemble type II carcinomas. Furthermore, expression of growth factor receptor HER2 has been found to be closely associated with serous ECs. We conducted a retrospective study on 142 patients in FIGO stages I and II with endometrioid EC and analyzed L1CAM and HER2 expression by double-staining immunohistochemistry...
February 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28221097/supplemental-breast-mr-imaging-screening-of-women-with-average-risk-of-breast-cancer
#18
Christiane K Kuhl, Kevin Strobel, Heribert Bieling, Claudia Leutner, Hans H Schild, Simone Schrading
Purpose To investigate the utility and accuracy of breast magnetic resonance (MR) imaging as a supplemental screening tool in women at average risk for breast cancer and to investigate the types of cancer detected with MR imaging screening. Materials and Methods This prospective observational study was conducted at two academic breast centers in women aged 40-70 years without breast cancer-associated risk factors (lifetime risk <15%). Between January 2005 and December 2013, women with at least minimal residual breast tissue (American College of Radiology categories A-D) and normal conventional imaging findings (screening mammography with or without screening ultrasonography [US]) were invited to undergo supplemental MR imaging screening...
February 21, 2017: Radiology
https://www.readbyqxmd.com/read/28220371/multiple-nonsyndromic-acquired-basal-cell-carcinomas-uncommon-clinical-presentation-in-a-bulgarian-patient
#19
Georgi Tchernev, Ivan Pidakev, Ilia Lozev, Torello Lotti, Uwe Wollina
Basal cell carcinoma is the most frequent cutaneous neoplasm, with slowly progressive nature and locally invasive behavior. Despite the low metastatic potential, local tissue destruction and disfigurement caused by the tumor can be large if not eradicated in time by early diagnosis and treatment. Both genetic predisposition and exposure to environmental risks are involved in the pathogenesis of the malignant transformation in BCC. The total number of nonmelanocytic skin cancers is a risk factor for recurrence of previous tumor, on the one hand, as well as for the formation of new ones, on the other...
February 20, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28220285/oral-cancer-early-detection-what-do-patients-need-to-know
#20
Yazan Hassona, F Sawair, D Matarweh, A Abdalhamid, D Thweib, C Scully
The purpose of the present study was to examine the educational needs of patients regarding early detection of oral cancer. A total of 790 patients without cancer were interviewed and shown a set of validated clinical images of various oral lesions including early oral cancer. Participants were asked about their perception of cancer and the action that they would take if they notice a similar lesion. Lower risk lesions (e.g., lumps) were more likely to be perceived as cancer (52.4%), while higher risk lesions (e...
February 20, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
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