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https://www.readbyqxmd.com/read/23960082/tyrosine-phosphorylation-on-spleen-tyrosine-kinase-syk-is-differentially-regulated-in-human-and-murine-platelets-by-protein-kinase-c-isoforms
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Lorena Buitrago, Dheeraj Bhavanasi, Carol Dangelmaier, Bhanu Kanth Manne, Rachit Badolia, Alessandra Borgognone, Alexander Y Tsygankov, Steven E McKenzie, Satya P Kunapuli
Protein kinase C (PKC) isoforms differentially regulate platelet functional responses downstream of glycoprotein VI (GPVI) signaling, but the role of PKCs regulating upstream effectors such as Syk is not known. We investigated the role of PKC on Syk tyrosine phosphorylation using the pan-PKC inhibitor GF109203X (GFX). GPVI-mediated phosphorylation on Syk Tyr-323, Tyr-352, and Tyr-525/526 was rapidly dephosphorylated, but GFX treatment inhibited this dephosphorylation on Tyr-525/526 in human platelets but not in wild type murine platelets...
October 4, 2013: Journal of Biological Chemistry
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