keyword
MENU ▼
Read by QxMD icon Read
search

Catastrophe

keyword
https://www.readbyqxmd.com/read/28930520/molecular-evolution-of-hemagglutinin-gene-of-influenza-a-virus
#1
Antara De
In the history of human civilization, influenza is the second most catastrophic killer disease for mankind with plague ranking first in the medieval times. The 1918-1919 'Spanish flu' killed 20-50 million people worldwide. According to a report from WHO, there have been four pandemics, several epidemics and recurrent seasonal outbreaks of influenza in different parts of the world. The virus is a potential bioterrorism threat with biological 'Chernobyl-like disaster' that occurred in Soviet Russia in 1977. Here, the author reviews the biology of the surface exposed hemagglutinin of the influenza virus, a gene under constant positive selection pressure to evade host immunity and vaccination...
January 1, 2018: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28928827/inhibition-of-c-myc-expression-accounts-for-an-increase-in-the-number-of-multinucleated-cells-in-human-cervical-epithelial-cells
#2
Feng Mei Cui, Xiu Jin Sun, Cheng Cheng Huang, Qiu Chen, Yong Ming He, Shi Meng Zhang, Hua Guan, Man Song, Ping Kun Zhou, Jun Hou
The present study aimed to explore the mechanisms by which c-Myc is involved in mitotic catastrophe. HeLa-630 is a cell line stably silenced for c-Myc expression that was established in the laboratory of the School of Radiation Medicine and Protection. Multinucleated cells were observed in this line, and gene expression analysis was utilized to examine differences in gene expression in these cells compared with in the control cells transfected with the control plasmid. Gene ontology analysis was performed for differentially expressed genes...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927911/characteristics-of-blood-blister-like-aneurysms-with-a-saccular-shape-appearance
#3
Hirofumi Nishikawa, Shigetoshi Shimizu, Hideki Nakajima, Yotaro Kitano, Takanori Sano, Genshin Mouri, Fumitaka Miya, Hidenori Suzuki
BACKGROUND: Blood blister-like aneurysms (BBAs) are a subgroup of aneurysms located on non-branching sites of the internal carotid artery (ICA) and characterized by small size, a fragile wall, and a poorly defined broad-based neck. Both direct surgery and endovascular treatment for BBA are often challenging. Some of them were reported to look like a true saccular aneurysm, and the misdiagnosis of BBA might result in catastrophic outcomes. The purpose of this study is to clarify the clinical and intraoperative findings of saccular BBAs...
September 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28927649/coping-with-pain-in-intimate-situations-applying-the-avoidance-endurance-model-to-women-with-vulvovaginal-pain
#4
I K Flink, L Engman, M M Ter Kuile, J Thomtén, S J Linton
BACKGROUND AND AIMS: Chronic vulvovaginal pain is strikingly common and has a serious impact on women's lives. Nevertheless, there are few longitudinal studies focusing on mechanisms involved in the pain development. One area of interest is how women cope with sexual activities and how this affects their pain. In this study, avoidance and endurance coping behaviors were explored as possible mediators of the relation between catastrophizing and pain, cross-sectionally and longitudinally...
September 15, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28927115/wee1-inhibition-by-mk1775-as-a-single-agent-therapy-inhibits-ovarian-cancer-viability
#5
Minghui Zhang, Donye Dominguez, Siqi Chen, Jie Fan, Lei Qin, Alan Long, Xia Li, Yi Zhang, Huirong Shi, Bin Zhang
Wee1-like protein kinase (WEE1) physiologically serves a key function in maintaining the integrity of the cell genome through mediating the activation of cyclin-dependent kinase (CDK)1 and CDK2. Increased expression of WEE1 has been associated with the poor prognosis of patients with ovarian cancer. The present study aimed at examining the in vitro and in vivo antitumor activity of MK1775, a potent pharmacological inhibitor of WEE1, as a single agent against ovarian cancer cells. The cytotoxicity of MK1775 was examined in a panel of tumor cells using MTT in vitro...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926881/-emphasizing-the-diagnosis-and-treatment-of-diabetes-related-dry-eye
#6
J Yuan, Y Q Deng
Nowadays, diabetes is quickly emerging as one of the biggest health-related catastrophes over the world. Its impact on people's quality of life has been gradually taken seriously. In the past few years, the connection linking dry eye to diabetes has been substantially confirmed by a series of studies. However, many areas remain uncertain due to the complex and diverse pathogeneses of diabetes related dry eye syndrome. Furthermore, the slow progression of dry eye symptoms easily conceals its connection with diabetes, which brings great challenges to timely diagnosis and effective interventions...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28926413/the-role-of-cognitive-content-and-cognitive-processes-in-chronic-pain-an-important-distinction
#7
Mark P Jensen, Beverly E Thorn, James Carmody, Francis J Keefe, John W Burns
Pain-related cognitive content (what people think about pain) and cognitive processes (how people think about pain; what they do with their pain-related thoughts) and their interaction are hypothesized to play distinct roles in patient function. However, questions have been raised regarding whether it is possible or practical to assess cognitive content and cognitive process as distinct domains. The aim of this study was to determine the extent to which measures that appear to assess mostly pain-related cognitive content, cognitive processes, and content and process, are relatively independent from each other and contribute unique variance to the prediction of patient function...
September 15, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28925395/small-molecules-targeted-to-the-microtubule-hec1-interaction-inhibit-cancer-cell-growth-through-microtubule-stabilization
#8
M Ferrara, G Sessa, M Fiore, F Bernard, I A Asteriti, E Cundari, G Colotti, S Ferla, M Desideri, S Buglioni, D Trisciuoglio, D Del Bufalo, A Brancale, F Degrassi
Highly expressed in cancer protein 1 (Hec1) is a subunit of the kinetochore (KT)-associated Ndc80 complex, which ensures proper segregation of sister chromatids at mitosis by mediating the interaction between KTs and microtubules (MTs). HEC1 mRNA and protein are highly expressed in many malignancies as part of a signature of chromosome instability. These properties render Hec1 a promising molecular target for developing therapeutic drugs that exert their anticancer activities by producing massive chromosome aneuploidy...
September 18, 2017: Oncogene
https://www.readbyqxmd.com/read/28925346/the-effect-of-winter-length-on-duration-of-dormancy-and-survival-of-specialized-herbivorous-rhagoletis-fruit-flies-from-high-elevation-environments-with-acyclic-climatic-variability
#9
J Rull, E Tadeo, R Lasa, M Aluja
Dormancy can be defined as a state of suppressed development allowing insects to cope with adverse conditions and plant phenology. Among specialized herbivorous insects exploiting seasonal resources, diapause frequently evolves as a strategy to adjust to predictable plant seasonal cycles. To cope with acyclic and unpredictable climatic events, it has been found for some insects that a proportion of the population undergoes prolonged dormancy. We compared the response of three species in the Rhagoletis cingulata species group exploiting plants differing in fruiting phenology from environments varying in frequency and timing of acyclic climatic catastrophic events (frost during flowering and fruit set) and varying also in the time of the onset of the rainy season...
September 19, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28924298/impressions-and-attitudes-of-adult-residents-of-karachi-towards-a-possible-public-health-insurance-scheme
#10
Vishal Farid Raza, Mustafa Iftikhar, Asma Gulab, Javeria Anwar, Maryam Tetlay, Sara Atif, Zoya Butt, Muhammad Hamza Khan, Asad Moiz, Marium Nadeem, Sarah Saleem
OBJECTIVE: To gauge the general population's knowledge and attitude towards a possible public health insurance scheme. METHODS: This descriptive, cross-sectional study was conducted at the Aga Khan University Hospital, Karachi, from April to May 2015, and comprised permanent residents of the city. Convenience sampling was used. Data was collected via questionnaires. SPSS 22 was used for data analysis. RESULTS: There were 340 participants in the study with an overall mean age of 32...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28923548/survival-of-extensively-damaged-endodontically-treated-incisors-restored-with-different-types-of-posts-and-core-foundation-restoration-material
#11
Priscilla Cardoso Lazari, Marco Aurélio de Carvalho, Altair A Del Bel Cury, Pascal Magne
STATEMENT OF PROBLEM: Which post-and-core combination will best improve the performance of extensively damaged endodontically treated incisors without a ferrule is still unclear. PURPOSE: The purpose of this in vitro study was to investigate the restoration of extensively damaged endodontically treated incisors without a ferrule using glass-ceramic crowns bonded to various composite resin foundation restorations and 2 types of posts. MATERIAL AND METHODS: Sixty decoronated endodontically treated bovine incisors without a ferrule were divided into 4 groups and restored with various post-and-core foundation restorations...
September 16, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28921609/biomarkers-for-equine-joint-injury-and-osteoarthritis
#12
REVIEW
C Wayne McIlwraith, Christopher E Kawcak, David D Frisbie, Christopher B Little, Peter D Clegg, Mandy J Peffers, Morten A Karsdal, Stina Ekman, Sheila Laverty, Richard A Slayden, Linda J Sandell, L Stefan Lohmander, Virginia B Kraus
We report the results of a symposium aimed at identifying validated biomarkers that can be used to complement clinical observations for diagnosis and prognosis of joint injury leading to equine osteoarthritis (OA). Biomarkers might also predict pre-fracture change that could lead to catastrophic bone failure in equine athletes. The workshop was attended by leading scientists in the fields of equine and human musculoskeletal biomarkers to enable cross-disciplinary exchange and improve knowledge in both. Detailed proceedings with strategic planning was written, added to, edited and referenced to develop this manuscript...
September 16, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28921477/out-of-pocket-expenditure-and-catastrophic-health-spending-on-maternal-care-in-public-and-private-health-centres-in-india-a-comparative-study-of-pre-and-post-national-health-mission-period
#13
Sanjay K Mohanty, Anshul Kastor
BACKGROUND: The National Health Mission (NHM), one of the largest publicly funded maternal health programs worldwide was initiated in 2005 to reduce maternal, neo-natal and infant mortality and out-of-pocket expenditure (OOPE) on maternal care in India. Though evidence suggests improvement in maternal and child health, little is known on the change in OOPE and catastrophic health spending (CHS) since the launch of NHM. AIM: The aim of this paper is to provide a comprehensive estimate of OOPE and CHS on maternal care by public and private health providers in pre and post NHM periods...
September 18, 2017: Health Economics Review
https://www.readbyqxmd.com/read/28919185/epidemiology-of-cervical-spine-injuries-in-high-school-athletes-over-a-ten-year-period
#14
Adele Meron, Christopher McMullen, Scott R Laker, Dustin Currie, R Dawn Comstock
BACKGROUND: Over 7 million athletes participate in high school (HS) sports annually, with both the benefits of physical activity and risks of injury. While catastrophic cervical spine injuries have been studied, limited data are available characterizing less severe cervical spine injuries in HS athletes. OBJECTIVE: To describe and compare cervical spine injury rates and patterns among United States (US) HS athletes across 24 sports over a ten-year period. DESIGN: Descriptive epidemiology study SETTING: National sample of high schools participating in the High School Reporting Information Online (High School RIO) injury surveillance system...
September 12, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28919156/chronic-low-back-pain-and-the-transdiagnostic-process-how-do-cognitive-and-emotional-dysregulations-contribute-to-the-intensity-of-risk-factors-and-pain
#15
M Le Borgne, A H Boudoukha, A Petit, Y Roquelaure
BACKGROUND AND AIMS: Based on a transdiagnostic approach, this study assesses the impact of cognitive and emotional processes (difficulties in emotional regulation, impulsiveness, rumination and somatosensory amplification) on the psychological risk factors of chronic low-back pain. METHODS: The study was carried out with 256 patients with chronic low-back pain. All the variables were assessed through a booklet of 10 validated questionnaires. Multiple regression analysis and moderation analysis were performed...
September 11, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28919155/context-sensitive-regulation-of-pain-and-emotion-development-and-initial-validation-of-a-scale-for-context-insensitive-avoidance
#16
Ida K Flink, Ester Klein-Strandberg, Steven J Linton
BACKGROUND AND AIMS: Context insensitivity has been put forward as a potential mechanism explaining the high co-occurrence of pain and emotional distress. In the pain literature, the concept has only been introduced at a theoretical level and an assessment tool for exploring its impact is lacking. In an interpersonal setting, a core aspect of context sensitivity and insensitivity concerns when to disclose and when to avoid expressing pain and related distress. Both context insensitive disclosure and context insensitive avoidance may hamper interpersonal support and fuel the problem...
September 11, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28917711/crocodiles-and-alligators-antiamoebic-and-antitumor-compounds-of-crocodiles
#17
Ruqaiyyah Siddiqui, Shareni Jeyamogan, Salwa Mansoor Ali, Fatima Abbas, K A Sagathevan, Naveed Ahmed Khan
Crocodiles exist in unsanitary environments, feed on rotten meat, are often exposed to heavy metals such as arsenic, cadmium, cobalt, chromium, mercury, nickel, lead, selenium, tolerate high levels of radiation, and are amid the very few species to survive the catastrophic Cretaceous-Tertiary extinction event, nonetheless they can live for up to a 100 years. Moreover, as they live in unhygienic conditions, they regularly come across pathogens. Logically, we postulate that crocodiles have established mechanisms to defend themselves from noxious agents as well as protecting themselves from pathogens...
September 13, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28917500/economic-evaluation-of-childhood-epilepsy-in-a-resource-challenged-setting-a-preliminary-survey
#18
Aliyu Ibrahim, Umar Isa Umar, Umar Musa Usman, Lukman Femi Owolabi
BACKGROUND: Considerable disease variability exists between patients with epilepsy, and the societal costs for epilepsy care are overall high, because of high frequency in the general population especially in children from developing countries. MATERIALS AND METHODS: A cross-sectional study where children with established diagnosis of epilepsy were interviewed using a semi-structured questionnaire. Prevalence-based costs were stratified by patients' sociodemographic characteristics and socioeconomic scores (SES)...
September 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28916678/gucy2c-signaling-opposes-the-acute-radiation-induced-gi-syndrome
#19
Peng Li, Evan Wuthrick, Jeff A Rappaport, Crystal Kraft, Jieru E Lin, Glen Marszalowicz, Adam E Snook, Tingting Zhan, Terry M Hyslop, Scott A Waldman
High doses of ionizing radiation induce acute damage to epithelial cells of the gastrointestinal (GI) tract, mediating toxicities restricting the therapeutic efficacy of radiation in cancer and morbidity and mortality in nuclear disasters. No approved prophylaxis or therapy exists for these toxicities, in part reflecting an incomplete understanding of mechanisms contributing to the acute radiation-induced GI syndrome (RIGS). Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury...
September 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28914487/illness-perceptions-explain-the-variance-in-functional-disability-but-not-habitual-physical-activity-in-patients-with-chronic-low-back-pain-a-cross-sectional-study
#20
Marijke Leysen, Jo Nijs, Paul Van Wilgen, Filip Struyf, Mira Meeus, Erik Fransen, Christophe Demoulin, Rob Smeets, Nathalie A Roussel
INTRODUCTION: Although the importance of psychosocial factors has been highlighted in many studies in patients with chronic low back pain (CLBP), there is a lack of research examining the role of illness perceptions in explaining functional disability and physical activity in patients with CLBP. AIM: The aim of the study was to explore the value of illness perceptions in explaining functional disability and physical activity in patients with CLBP. METHODS: Eighty-four participants with CLBP (> 3 months) completed a battery of questionnaires investigating psychosocial factors (pain catastrophizing scale (PCS), illness perceptions questionnaire revised (IPQ-R) and SF-36 mental health scale (SF-36_MH)) as well as the perceived pain intensity (VAS), Oswestry Disability Index (ODI) and Baecke questionnaire...
September 15, 2017: Pain Practice: the Official Journal of World Institute of Pain
keyword
keyword
60228
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"