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https://www.readbyqxmd.com/read/29150987/therapeutic-effect-of-curcumin-and-methylprednisolone-in-the-rat-spinal-cord-injury
#1
Xuehong Liu, Yong Zhang, Yang Yang, Jingquan Lin, Xue Huo, Xiaoxue Du, Benson O A Botchway, Marong Fang
In addition to imperiling an individual's daily life, spinal cord injury (SCI), a catastrophic medical damage, can permanently impair an individual's body function. Methylprednisolone (MP), a medically accepted therapeutic drug for SCI, is highly controversial for the lack of consensus on its true therapeutic effect. In recent years, curcumin has served as a potential and novel therapeutic drug in SCI. Our study was intended to investigate the precise effect of MP and curcumin in SCI. We examined the function of MP and curcumin in a SCI model rat, both in vivo and in vitro, and found that there was a momentous improvement in Basso-Beattie-Bresnahan (BBB) scores in the MP-treated group when compared to Cur-treated group within 14 days...
November 18, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29150727/measuring-emotional-intelligence-enhances-the-psychological-evaluation-of-chronic-pain
#2
Eva M Doherty, Rosemary Walsh, Leanne Andrews, Susan McPherson
The assessment of emotional factors, in addition to other psychosocial factors, has been recommended as a means of identifying individuals with chronic pain who may not respond to certain pain treatments. Systematic reviews of the evidence regarding the prediction of responsiveness to a treatment called the spinal cord stimulator (SCS) have yielded inconclusive results. Emotional intelligence is a term which refers to the ability to identify and manage emotions in oneself and others and has been shown to be inversely associated with emotional distress and acute pain...
November 17, 2017: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29149181/hospital-utilization-and-out-of-pocket-expenditure-in-public-and-private-sectors-under-the-universal-government-health-insurance-scheme-in-chhattisgarh-state-india-lessons-for-universal-health-coverage
#3
Sulakshana Nandi, Helen Schneider, Priyanka Dixit
Research on impact of publicly financed health insurance has paid relatively little attention to the nature of healthcare provision the schemes engage. India's National Health Insurance Scheme or RSBY was made universal by Chhattisgarh State in 2012. In the State, public and private sectors provide hospital services in a context of extensive gender, social, economic and geographical inequities. This study examined enrolment, utilization (public and private) and out of pocket (OOP) expenditure for the insured and uninsured, in Chhattisgarh...
2017: PloS One
https://www.readbyqxmd.com/read/29149149/decreased-regional-grey-matter-volume-in-women-with-chronic-whiplash-associated-disorders-relationships-with-cognitive-deficits-and-disturbed-pain-processing
#4
Iris Coppieters, Robby De Pauw, Karen Caeyenberghs, Lieven Danneels, Jeroen Kregel, Astrid Pattyn, Mira Meeus, Barbara Cagnie
BACKGROUND: Patients with chronic whiplash-associated disorders (CWAD) are characterized by pain of traumatic origin, cognitive deficits, and central sensitization (CS). Previous neuroimaging studies revealed altered grey matter volume (GMV) in mild traumatic brain injury patients and chronic pain conditions also characterized by CS. It can therefore be hypothesized that GMV alterations also play a role in the persistent complaints of CWAD. However, brain alterations remain poorly investigated in these patients...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29148655/feframing-climate-change-for-environmental-health
#5
Caitlin Weems, Prithwi Raj Subramaniam
Repeated warnings by the scientific community on the dire consequences of climate change through global warming to the ecology and sustenance of our planet have not been give appropriate attention by the U.S. public. Research has shown that climate change is responsible for catastrophic weather occurrences--such as floods, tornadoes, hurricanes, and heat waves--resulting in environmental and public health issues. The purpose of this report is to examine factors influencing public views on climate change. Theoretical and political perspectives are examined to unpack opinions held by the public in the U...
April 2017: Journal of Environmental Health
https://www.readbyqxmd.com/read/29148620/perceptions-of-adults-with-overweight-obesity-and-chronic-musculoskeletal-pain-an-interpretative-phenomenological-analysis
#6
Lesley Cooper, Louisa Ells, Cormac Ryan, Denis Martin
AIMS: To gain insight into the lived experience of adults with overweight/obesity and chronic musculoskeletal pain (CMP). Knowledge gained will inform healthcare professionals about the complexity of the weight-pain relationship and enable more effective engagement with this population BACKGROUND: Quantitative studies show links between weight and pain. Adults with overweight/obesity are more likely to experience comorbidity however, qualitative research describing the complexities of the relationship is limited...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29147113/clinical-presentation-management-and-outcomes-of-primary-hyperparathyroidism-during-pregnancy
#7
Ya Hu, Ming Cui, Zhengyi Sun, Zhe Su, Xiang Gao, Quan Liao, Yupei Zhao
Background: Primary hyperparathyroidism (pHPT) in pregnancy is a rare event, but it poses a significant risk to mothers and fetuses. The optimal treatment strategy remains controversial. Methods: We present a consecutive series of twelve pregnant women with pHPT. Results: Twelve women were diagnosed with pHPT during pregnancy or in the postpartum period. Four of them presented no symptoms or mild symptoms. Four patients experienced serious complications, including hypercalcaemic crisis, acute pancreatitis, and eclampsia...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29145865/the-endonuclease-eepd1-mediates-synthetic-lethality-in-rad52-depleted-brca1-mutant-breast-cancer-cells
#8
Robert Hromas, Hyun-Suk Kim, Gurjit Sidhu, Elizabeth Williamson, Aruna Jaiswal, Taylor A Totterdale, Jocelyn Nole, Suk-Hee Lee, Jac A Nickoloff, Kimi Y Kong
BACKGROUND: Proper repair and restart of stressed replication forks requires intact homologous recombination (HR). HR at stressed replication forks can be initiated by the 5' endonuclease EEPD1, which cleaves the stalled replication fork. Inherited or acquired defects in HR, such as mutations in breast cancer susceptibility protein-1 (BRCA1) or BRCA2, predispose to cancer, including breast and ovarian cancers. In order for these HR-deficient tumor cells to proliferate, they become addicted to a bypass replication fork repair pathway mediated by radiation repair protein 52 (RAD52)...
November 16, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29145413/diffusion-based-neuromodulation-can-eliminate-catastrophic-forgetting-in-simple-neural-networks
#9
Roby Velez, Jeff Clune
A long-term goal of AI is to produce agents that can learn a diversity of skills throughout their lifetimes and continuously improve those skills via experience. A longstanding obstacle towards that goal is catastrophic forgetting, which is when learning new information erases previously learned information. Catastrophic forgetting occurs in artificial neural networks (ANNs), which have fueled most recent advances in AI. A recent paper proposed that catastrophic forgetting in ANNs can be reduced by promoting modularity, which can limit forgetting by isolating task information to specific clusters of nodes and connections (functional modules)...
2017: PloS One
https://www.readbyqxmd.com/read/29145183/catastrophe-reaction-and-emotionalism
#10
Antonio Carota, Julien Bogousslavsky
The catastrophic reaction (CR; a disruptive and uncontrolled behavior triggered by anger, irritability, and hostility) and emotionalism (a condition of uncontrolled crying or laughing) are disorders of the emotional regulation and expression, the prevalence of which is underestimated in neurology. Their occurrence is an additional factor of poor outcome for neurologic patients. Although they have been recognized and completely described in their clinical manifestations more than a century ago, many issues remain unsolved regarding their pathogenesis and the respective role of the brain damage and psychological factors...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29144428/resistance-of-magnesium-alloys-to-corrosion-fatigue-for-biodegradable-implant-applications-current-status-and-challenges
#11
REVIEW
R K Singh Raman, Shervin Eslami Harandi
Magnesium (Mg) alloys are attracting increasing interest as the most suitable metallic materials for construction of biodegradable and bio-absorbable temporary implants. However, Mg-alloys can suffer premature and catastrophic fracture under the synergy of cyclic loading and corrosion (i.e., corrosion fatigue (CF)). Though Mg alloys are reported to be susceptible to CF also in the corrosive human body fluid, there are very limited studies on this topic. Furthermore, the in vitro test parameters employed in these investigations have not properly simulated the actual conditions in the human body...
November 16, 2017: Materials
https://www.readbyqxmd.com/read/29143968/correlating-the-vibrational-spectra-of-structurally-related-molecules-a-spectroscopic-measure-of-similarity
#12
Yunwen Tao, Wenli Zou, Dieter Cremer, Elfi Kraka
Using catastrophe theory and the concept of a mutation path, an algorithm is developed that leads to the direct correlation of the normal vibrational modes of two structurally related molecules. The mutation path is defined by weighted incremental changes in mass and geometry of the molecules in question, which are successively applied to mutate a molecule into a structurally related molecule and thus continuously converting their normal vibrational spectra from one into the other. Correlation diagrams are generated that accurately relate the normal vibrational modes to each other by utilizing mode-mode overlap criteria and resolving allowed and avoided crossings of vibrational eigenstates...
November 16, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29143388/in-vitro-assessment-of-retention-and-resistance-failure-loads-of-teeth-restored-with-a-complete-coverage-restoration-and-different-core-materials
#13
Vasileia Tsiagali, Yvoni Kirmanidou, Argirios Pissiotis, Konstantinos Michalakis
PURPOSE: To investigate in vitro the retention and the resistance form, as well as the failure modes of maxillary premolars restored with cast metal crowns and different core materials. MATERIALS AND METHODS: Sixty human extracted maxillary premolars were selected according to their size and were embedded in PMMA resin blocks. After removing a part of their clinical crowns, the teeth were randomly divided into 3 groups of 20 teeth and were either left unrestored, or they were restored with amalgam or composite resin...
November 16, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29143091/risk-of-catastrophic-health-expenditure-in-rwandan-surgical-patients-with-peritonitis
#14
J L Rickard, C Ngarambe, L Ndayizeye, B Smart, J P Majyambere, R Riviello
BACKGROUND: Surgical procedures are cost-effective compared with various medical and public health interventions. While peritonitis often requires surgery, little is known regarding the associated costs, particularly in low- and middle-income countries. The aim of this study was to determine in-hospital charges for patients with peritonitis and if patients are at risk of catastrophic health expenditure. METHODS: As part of a larger study examining the epidemiology and outcomes of patients with peritonitis at a referral hospital in Rwanda, patients undergoing operation for peritonitis were enrolled and hospital charges were examined...
November 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29142903/beti-induction-of-mitotic-catastrophe-towing-the-lin9
#15
EDITORIAL
Sylvia S Gayle, Jennifer M Sahni, Ruth A Keri
No abstract text is available yet for this article.
September 2017: Oncoscience
https://www.readbyqxmd.com/read/29142758/ethnic-differences-in-patients-perceptions-towards-isolated-orthopedic-injuries-a-pilot-study
#16
Boris A Zelle, Gurpreet Singh, Deanna L Kitchen, Roberto J Fajardo, Mohit Bhandari, Melissa A Valerio
Background: Patients' perceptions of their healthcare have been reported to influence clinical outcomes following orthopedic trauma. Findings across clinical outcomes have demonstrated significant differences in perceptions towards healthcare between Hispanics and non-Hispanic whites. However, ethnic disparities in perceptions towards orthopedic injuries have not been examined in the literature. Aim of study: The aim of this pilot study is to explore whether Hispanic patients with isolated orthopedic injuries will demonstrate different perceptions towards their injury as compared to non-Hispanic white patients...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29141634/the-effects-of-neoliberal-policies-on-access-to-healthcare-for-people-with-disabilities
#17
Dikaios Sakellariou, Elena S Rotarou
Neoliberal reforms lead to deep changes in healthcare systems around the world, on account of their emphasis on free market rather than the right to health. People with disabilities can be particularly disadvantaged by such reforms, due to their increased healthcare needs and lower socioeconomic status. In this article, we analyse the impacts of neoliberal reforms on access to healthcare for disabled people. This article is based on a critical analytical review of the literature and on two case studies, Chile and Greece...
November 15, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29141184/unrecognized-venous-injuries-after-cardiac-implantable-electronic-device-transvenous-lead-extraction
#18
Khaldoun G Tarakji, Walid Saliba, Danny Markabawi, E Rene Rodriguez, Yoaav Krauthammer, Michael P Brunner, Ayman A Hussein, Bryan Baranowski, Daniel J Cantillon, Mohamed Kanj, Mark Niebauer, Jack Rickard, Thomas Callahan, Mingyuan Shao, David O Martin, Oussama M Wazni, Bruce L Wilkoff, Carmela D Tan
BACKGROUND: Major complication rate of transvenous lead extraction (TLE) is estimated around 1-2.0%. Laceration of the central veins can be fatal. OBJECTIVES: to define the incidence and extent of venous injuries on a microscopic level after TLE and compare it with the incidence of clinically documented events of venous laceration. METHODS: We studied all patients who underwent TLE at our tertiary center within 30 months via a variety of techniques...
November 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29140634/combustibility-determination-for-cotton-gin-dust-and-almond-huller-dust
#19
Sidney E Hughs, Phillip J Wakelyn
It has been documented that some dusts generated while processing agricultural products, such as grain and sugar, can constitute combustible dust hazards. After a catastrophic dust explosion in a sugar refinery in 2008, the Occupational Safety and Health Administration (OSHA) initiated action to develop a mandatory standard to comprehensively address the fire and explosion hazards of combustible dusts. Cotton fiber and related materials from cotton ginning, in loose form, can support smoldering combustion if ignited by an outside source...
April 26, 2017: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29138049/pain-neurophysiology-education-and-therapeutic-exercise-for-patients-with-chronic-low-back-pain-a-single-blind-randomized-controlled-trial
#20
Bodes Pardo Gema, Lluch Girbés Enrique, Roussel Nathalie A, Gallego Izquierdo Tomás, Jiménez Penick Virginia, Pecos Martín Daniel
AIM: To assess the effect of a pain neurophysiology education program plus therapeutic exercise for patients with chronic low back pain (CLBP). DESIGN: Single-blind randomized controlled trial. SETTING: Private clinic (Clínica Bonn) and Alcalá de Henares University, Madrid, Spain. PARTICIPANTS: 56 patients with CLBP for 6 months or more. INTERVENTION: Participants were randomized to receive either a therapeutic exercise (TE) program consisting of motor control, stretching, and aerobic exercises (TE group, n=28) or the same therapeutic exercise program in addition to a pain neurophysiology education program (PNE+TE group, n=28), conducted in two 30 to 50 minute sessions in groups of 4 to 6 participants...
November 11, 2017: Archives of Physical Medicine and Rehabilitation
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