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https://www.readbyqxmd.com/read/28728287/-analysis-of-structure-and-function-of-meibomian-glands-in-healthy-population-at-different-ages
#1
J Hong, H Q Qu
Objective: To observe the structure and function of meibomian glands in normal population at different ages. Methods: From October 2011 to August 2012, meibomian gland information was collected in healthy volunteers without any symptoms of ocular discomfort, aged more than 5 years. The people were grouped by every 10 years of age. The meibomian gland opening, secretion state and characteristics and Max's line were observed by slit lamp microscopic examination, and the meibomian gland dropouts were examined by noncontact infrared meibomian gland microscopy...
July 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28728282/-epidemiologic-study-of-tear-film-lipid-layer-thickness-measurement-in-the-population-of-taishitun-community-in-beijing
#2
Q F Liang, X H Du, Y D Su, N L Wang, Z J Wei, Antoine Labbé
Objective: To investigate the distribution of tear film lipid layer thickness (LLT) and the relationship between symptoms and signs of dry eye and tear film LLT in the population of Taishitun Community in Beijing. Methods: A cross-sectional study. From May 2016 to August 2016, three streets of Taishitun Community were randomly selected as survey districts and 540 persons were taken as investigation subjects. Every participant completed 6 items of dry eye examinations as follows: questionnaire (Ocular Surface Disease Index, OSDI), measurement of tear film LLT, tear film break-up time (TBUT), corneal and conjunctival staining, SchirmerⅠtest and the infrared meibomian photography...
July 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28696955/pediatric-blepharokeratoconjunctivitis-is-there-a-right-treatment
#3
Sepideh T Rousta
PURPOSE OF REVIEW: This article highlights the importance of recognizing blepharokeratoconjunctivitis (BKC) in children and reviews the clinical characteristics and current therapeutic modalities. RECENT FINDINGS: The mainstay of BKC treatment remains controlling the meibomian gland inflammation and treating cobormid conditions. BKC can occur in the setting of ocular rosacea and Demodex infestation. Small studies have shown treatment benefits of topical cyclosporine A as well as oral azithromycin in pediatric BKC...
July 10, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28694455/asymptomatic-meibomian-gland-dysfunction-and-cardiovascular-disease-risk-factors-in-a-middle-aged-population-in-taiwan-a-cross-sectional-analysis
#4
Alexander Chen, Hung-Ta Chen, Hung-Chi Chen, Yi-Tsun Chen, Yih-Hsiou Hwang, Chi-Chin Sun, Ching-Hsi Hsiao, David Hui-Kang Ma, Wei-Chi Wu, Chi-Chun Lai
Managing cardiovascular disease (CVD) risk factors is the key to prevent CVD. This study aimed to prevent CVD by introducing asymptomatic meibomian gland dysfunction (MGD), a condition associated with various CVD risk factors, as an early indicator for CVD in middle-aged population. Participants with and without asymptomatic MGD underwent standardized questionnaires, physical examinations, and laboratory investigations. One ophthalmologist completed the identification and grading of MGD by using slit-lamp biomicroscopy examination on the eyelid margins, meibomian gland orifices, and meibomian gland secretions...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28689165/tear-film-and-ocular-surface-assessment-in-psoriasis
#5
Emanuela Aragona, Laura Rania, Elisa Imelde Postorino, Alberto Interdonato, Roberta Giuffrida, Serafinella Patrizia Cannavò, Domenico Puzzolo, Pasquale Aragona
BACKGROUND: Psoriasis is a skin disease with also systemic involvement: its impact on the eye is not well established and often clinically underestimated. Aim of this study was to investigate the presence of ocular discomfort symptoms and of ocular surface changes in a population of patients with psoriasis. METHODS: For this cross-sectional, comparative study, 66 patients with psoriasis were subdivided according to the presence of arthritis and to the use of biological therapy...
July 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28688025/dyslipidemia-and-its-association-with-meibomian-gland-dysfunction-a-systematic-review
#6
REVIEW
Robin K Kuriakose, Puneet S Braich
PURPOSE: To perform a systematic review of the literature examining the association between meibomian gland dysfunction (MGD) and dyslipidemia. METHODS: A systematic literature search was performed using the Medline database. A total of four studies directly relevant to our search are reviewed here. RESULTS: In a series of four studies, all but one found that the prevalence of dyslipidemia was significantly higher in those with MGD compared to those without...
July 7, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28677153/assessment-of-efficacy-of-topical-azithromycin-1-5-per-cent-ophthalmic-solution-for-the-treatment-of-meibomian-gland-dysfunction
#7
Ozlem Balci, Gokhan Gulkilik
BACKGROUND: The aim was to evaluate the clinical efficacy of topical azithromycin 1.5 per cent ophthalmic solution in treatment of the clinical signs and symptoms associated with meibomian gland dysfunction (MGD). METHODS: In this retrospective study, 35 patients with MGD were treated with topical azithromycin 1.5 per cent ophthalmic solution for 30 days. Topical azithromycin 1.5 per cent ophthalmic solution was prescribed twice daily for two days and then once daily for a total of 30 days...
July 4, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28669846/meibomian-glands-meibum-and-meibogenesis
#8
REVIEW
Igor A Butovich
Meibum is a lipid-rich secretion that is produced by fully differentiated meibocytes in the holocrine Meibomian glands (MG) of humans and most mammals. The secretion is a part of a defense mechanism that protects the ocular surface from hazardous environmental factors, and from desiccation. Meibomian lipids that have been identified in meibum are very diverse and unique in nature. The lipid composition of meibum is different from virtually any other lipid pool found in the human body. In fact, meibum is quite different from sebum, which is the closest secretion that is produced by anatomically, physiologically, and biochemically related sebaceous glands...
June 29, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28655773/ectodysplasin-a-promotes-corneal-epithelial-cell-proliferation
#9
Sanming Li, Jing Zhou, Jinghua Bu, Ke Ning, Liying Zhang, Juan Li, Yuli Guo, Xin He, Hui He, Xiaoxin Cai, Yongxiong Chen, Peter Sol Reinach, Zuguo Liu, Wei Li
The EDA gene encodes ectodysplasin A (Eda) which if mutated causes X-linked Hypohidrotic Ectodermal Dysplasia (XLHED) disease in humans. Ocular surface changes occur in XLHED patients while its underlying mechanism remains elusive. In this study, we found Eda was highly expressed in meibomian glands, and it was detected in human tears but not serum. Corneal epithelial integrity was defective and the thickness was reduced in the early postnatal stage of EDA mutant Tabby mice. Corneal epithelial cell proliferation decreased and the epithelial wound healing was delayed in Tabby mice, while it was restored by exogenous Eda...
June 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28646862/a-clinical-utility-assessment-of-the-automatic-measurement-method-of-the-quality-of-meibomian-glands
#10
Robert Koprowski, Lei Tian, Paweł Olczyk
BACKGROUND: Meibomian gland dysfunction (MGD) is one of the most common diseases observed in clinics and is the leading cause of evaporative dry eye. Today, diagnostics of MGD is not fully automatic yet and is based on a qualitative assessment made by an ophthalmologist. Therefore, an automatic analysis method was developed to assess MGD quantiatively. MATERIALS: The analysis made use of 228 images of 57 patients recorded by OCULUS Keratograph(®) 5 M with a resolution of 1024 × 1360 pixels concern 30 eyes of healthy individuals (14 women and 16 men) and 27 eyes of sick patients (10 women and 17 men)...
June 24, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28645677/dry-eye-and-meibomian-gland-dysfunction-with-meibography-in-patients-with-lamellar-ichthyosis
#11
Melis Palamar, Irmak Karaca, Huseyin Onay, Ilgen Ertam, Ayse Yagci
PURPOSE: To evaluate the dry eye findings and Meibomian gland dysfunction as demonstrated with meibography in patients with lamellar ichthyosis. METHODS: Twenty-four eyes of 12 patients with lamellar ichthyosis (Group 1) and twenty-four eyes of 12 healthy individuals (Group 2) were enrolled. Comprehensive eye examination along with corneal and conjunctival fluorescein staining with Oxford scoring, tear film break-up time, Schirmer 1 test, ocular surface disease index (OSDI) score assessment, and evaluation of upper and lower eyelid Meibomian glands using infrared filter of slit-lamp biomicroscope (SL-D701, TOPCON, Tokyo, Japan) were performed...
June 20, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28628504/morphology-and-function-of-meibomian-glands-and-other-tear-film-parameters-in-junior-high-school-students
#12
Takanori Mizoguchi, Reiko Arita, Shima Fukuoka, Naoyuki Morishige
PURPOSE: We measured tear film parameters, including the morphology and function of meibomian glands, in junior high school students at 15 years of age. METHODS: A total of 111 eyes of 111 students (56 males and 55 females) were enrolled in the study. The ocular symptom score (0-14), after-school study time, lipid layer thickness (LLT) of the tear film, partial blink rate, lid margin abnormalities (0-4), tear film breakup time, corneal and conjunctival epithelial damage (fluorescein staining score, 0-9), meiboscore as determined by noncontact meibography (0-6), Schirmer test value, and meibum grade (0-3) were determined...
June 14, 2017: Cornea
https://www.readbyqxmd.com/read/28615923/changes-in-meibomian-gland-morphology-and-ocular-higher-order-aberrations-in-eyes-with-chalazion
#13
Shima Fukuoka, Reiko Arita, Rika Shirakawa, Naoyuki Morishige
PURPOSE: To examine the changes in meibomian gland morphology and ocular higher-order aberrations (HOAs) in eyes with chalazion and its excision. METHODS: Seven male patients with previous history of chalazion excision and seven control male subjects were enrolled. Changes in meibomian gland morphology (meiboscores, gland dropout, and shortening) were evaluated by using meibography equipped in a wavefront analyzer KR-1W and in a slit-lamp device BG-4M. Ocular HOAs were measured sequentially with KR-1W...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28598963/response-to-the-association-of-chronic-topical-prostaglandin-analog-use-with-meibomian-gland-dysfunction-comment
#14
Mehmet C Mocan, Enes Uzunosmanoglu, Sibel Kocabeyoglu, Jale Karakaya, Murat Irkec
No abstract text is available yet for this article.
June 8, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28593054/meibomian-gland-dysfunction-in-type-2-diabetic-patients
#15
Xiaolei Lin, Binbin Xu, Yuxi Zheng, Terry G Coursey, Yinying Zhao, Junhua Li, Yana Fu, Xuewen Chen, Yun-E Zhao
PURPOSE: To investigate meibomian gland and tear film function in patients with type 2 diabetes. METHODS: This prospective study compared changes in meibomian gland and tear film function in type 2 diabetic patients with nondiabetic patients. Meibomian gland function was evaluated by measuring lipid layer thickness (LLT), grading of meibomian gland loss, lid margin abnormalities, and expression of meibum. Tear film function was assessed by measuring tear breakup time (TBUT), the Schirmer I test, noninvasive breakup time (NIBUT), tear meniscus height (TMH), and corneal fluorescein staining...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28592418/growth-of-meibomian-gland-tissue-after-intraductal-meibomian-gland-probing-in-patients-with-obstructive-meibomian-gland-dysfunction
#16
Steven L Maskin, Whitney R Testa
PURPOSE: To investigate the impact of meibomian gland probing (MGP) on meibomian gland (MG) area from the upper lids of patients with obstructive meibomian gland dysfunction (o-MGD). METHODS: Retrospective study comparing pre-MGP/post-MGP non-contact infrared meibography results in patients with o-MGD, viewing signs of MG growth within total measurement field. RESULTS: Post-MGP meibography of 34 lids (19 patients, ≥4.5 to ≤12 months' follow-up) showed 41...
June 7, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28592257/clinical-safety-and-efficacy-of-vitamin-d3-analog-ointment-for-treatment-of-obstructive-meibomian-gland-dysfunction
#17
Reiko Arita, Motoko Kawashima, Masataka Ito, Kazuo Tsubota
BACKGROUND: Hyperkeratinization is a major cause of obstructive meibomian gland dysfunction (oMGD) and results in degenerative gland dilation and atrophy without inflammation. Ointment containing 1,25-dihydroxy-22-oxavitamin D3 (maxacalcitol), a noncalcemic analog of the active form of vitamin D3, is applied for the treatment of hyperkeratotic cutaneous conditions such as psoriasis and ichtyosis because it suppresses the proliferation and promotes the differentiation of keratinocytes through interaction with the vitamin D receptor...
June 7, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28587370/a-novel-noninvasive-ocular-surface-analyzer-for-the-assessment-of-dry-eye-with-meibomian-gland-dysfunction
#18
Yuanyuan Qi, Chen Zhang, Shaozhen Zhao, Yue Huang, Ruibo Yang
Meibomian gland dysfunction (MGD) is a major cause of dry eye, and the purpose of the present study was to evaluate the differences between dry eye patients with MGD and controls using a novel noninvasive ocular surface analyzer. A total of 33 dry eye patients with MGD and 31 controls were enrolled in the present study. Testing included administration of the Ocular Surface Disease Index (OSDI), followed by Keratogragh 5M (Oculus, Wetzlar, Germany), measurements of the noninvasive tear film break-up times (NITBUTs), the first tear film break-up point and the morphology of meibomian gland...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28585267/intense-pulsed-light-treatment-and-meibomian-gland-expression-for-moderate-to-advanced-meibomian-gland-dysfunction
#19
Julie M Albietz, Katrina L Schmid
BACKGROUND: The aim was to evaluate the efficacy of periocular intense pulsed light therapy combined with meibomian gland expression for chronic dry eye due to moderate to advanced meibomian gland dysfunction. METHODS: This single-institution, open-label prospective study involved 26 participants who received bilateral treatments using a proprietary intense pulsed light device (E > Eye, E-Swin, Paris, France) combined with therapeutic meibomian gland expression at baseline, Week 2 and Week 6...
June 6, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28585260/randomised-controlled-trial-of-topical-antibacterial-manuka-leptospermum-species-honey-for-evaporative-dry-eye-due-to-meibomian-gland-dysfunction
#20
Julie M Albietz, Katrina L Schmid
BACKGROUND: The aim was to evaluate the efficacy of standardised Manuka (Leptospermum species) antibacterial honey as adjunctive twice daily treatment to conventional therapy (warm compresses, lid massage and preservative-free lubricant), in participants with evaporative dry eye due to moderate to advanced meibomian gland dysfunction. METHODS: This prospective, open-label study involved 114 participants. After two weeks of conventional therapy participants were randomised to one of three treatment groups: Optimel Antibacterial Manuka Eye Gel (98 per cent Leptospermum species honey) plus conventional therapy (n = 37), Optimel Manuka plus Lubricant Eye Drops (16 per cent Leptospermum species honey) plus conventional therapy (n = 37) and a control (conventional therapy) (n = 40)...
June 6, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
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