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Meibomian

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https://www.readbyqxmd.com/read/29033270/a-survey-of-contact-lens-related-complications-in-a-tertiary-hospital-in-china
#1
Weiwei Li, Xuguang Sun, Zhiqun Wang, Yang Zhang
PURPOSE: To describe the type of complications related to contact lens (CL) wear in a tertiary hospital in XX, China. METHODS: A retrospective study of 141 patients who complained discomfort after wearing contact lens on an outpatient basis of XX Hospital were conducted from the January 2012 to December 2015. The data included patients' demographics, lens type, history, slit-lamp examination, reports of corneal scrapings, culture, and examination of in vivo confocal microscopy...
October 12, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28982950/advances-in-dry-eye-imaging-the-present-and-beyond
#2
REVIEW
Tommy C Y Chan, Kelvin H Wan, Kendrick C Shih, Vishal Jhanji
New advances in imaging allow objective measurements for dry eye as well as define new parameters that cannot be measured by clinical assessment alone. A combination of these modalities provides unprecedented information on the static and dynamic properties of the structural and functional parameters in this multifactorial disease. A literature search was conducted to include studies investigating the use of imaging techniques in dry eye disease. This review describes the application of non-invasive tear breakup time, optical coherence tomography, meibomian gland imaging, interferometry, in vivo confocal microscopy, thermography and optical quality assessment for this condition...
October 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28974425/comparison-of-treatment-effect-across-varying-severities-of-meibomian-gland-dropout
#3
Philip R K Turnbull, Stuti L Misra, Jennifer P Craig
PURPOSE: Better understanding of the pathophysiology of meibomian gland dysfunction (MGD) has provided the opportunity to develop treatments which could be tailored for specific presentations of MGD. This study sought to directly compare treatment effectiveness for three current therapies across differing levels of MG dropout. METHODS: Subjects (n=81), grouped by infrared meibography dropout proportions, into either no (control), mild, or pronounced MG dropout, were randomised to receive treatment with a latent heat device (n=25), liposomal spray (n=28), or heated warm compress (n=28)...
September 30, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28958587/investigation-of-antioxidant-systems-in-human-meibomian-gland-and-conjunctival-tissues
#4
Hachemi Nezzar, Joyce N Mbekeani, Anais Noblanc, Frédéric Chiambaretta, Joël R Drevet, Ayhan Kocer
Oxidative stress associated with direct contact with the environment and light exposure is one very potent and continuous stressor of the ocular surface and more internal structures of the eye that should cope with it. Permanent replenishment of tears together with its superficial lipid layer produced by the meibomian glands (MG) is one protective mechanism. The lipid-rich fraction of the tears is there to prevent evaporation of the more aqueous fractions, however lipids are particularly sensitive to oxidative damage that could thus alter tear film quality...
September 27, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28957980/functional-morphology-of-the-lipid-layer-of-the-tear-film
#5
Reiko Arita, Shima Fukuoka, Naoyuki Morishige
Meibomian glands secrete the oily layer of the tear film, which prevents excessive evaporation of tear fluid. Dysfunction of meibomian glands is not only one of the causes of evaporative dry eye but also one of the main causes of entire dry eye. To understand the pathophysiology of meibomian gland dysfunction, it is important to evaluate both the morphology and function of the meibomian gland. We previously reported that meibography enabled visualization of the morphology of the meibomian gland. Meanwhile, tear interferometry was introduced as an evaluation method for the function of the meibomian gland...
November 2017: Cornea
https://www.readbyqxmd.com/read/28957399/risk-factors-for-severe-meibomian-gland-atrophy-in-a-young-adult-population-a-cross-sectional-study
#6
Thao N Yeh, Meng C Lin
PURPOSE: Assess potential risk factors for severe Meibomian gland atrophy (SMGA) in a young adult population. METHODS: Cross-sectional study using medical history and ocular surface examination to evaluate relationships with study outcomes: SMGA, tear lipid layer (TLL) thickness, non-invasive (NITBUT) and fluorescein (FTBUT) tear breakup times, and symptoms using the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire. RESULTS: One hundred one participants (101; 202 eyes; Age: mean±SD = 22...
2017: PloS One
https://www.readbyqxmd.com/read/28950941/ocular-surface-inflammation-impairs-structure-and-function-of-meibomian-gland
#7
REVIEW
Shin Mizoguchi, Hiroki Iwanishi, Reiko Arita, Kumi Shirai, Takayoshi Sumioka, Masahide Kokado, James V Jester, Shizuya Saika
Dysfunction of the meibomian glands alters secreted meibum quantitatively and qualitatively that can lead to damage to the ocular surface epithelium. In response to an unstable tear film cause by meibomian gland dysfunction, ocular surface epithelium is damaged and expresses inflammatory cytokines leading to secondary ocular inflammation. In turn, inflammatory disorders of the palpebral conjunctiva and lid margin may affect the structure and function of meibomian gland. The disorders include allergic conjunctivitis, long-term usage of contact lenses, dermatological diseases that affect conjunctival homeostasis, Stevens-Johnson's syndrome or chemical burning of the ocular surface and lid margin...
October 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28950940/morphological-evaluation-for-diagnosis-of-dry-eye-related-to-meibomian-gland-dysfunction
#8
REVIEW
Young-Sik Yoo, Kyung-Sun Na, Dae Yu Kim, Suk-Woo Yang, Choun-Ki Joo
The evaluation of morphological changes of the acini in the meibomian glands is important for the diagnosis and management of dry eye related to meibomian gland dysfunction. While several tools have been developed to detect meibomian gland structure, infrared imaging is generally used in clinical settings. Unlike the lipid component analysis of tear film in which quantitative analysis is possible, the meibomian glands are limited to qualitative analysis because of the low image quality of the diagnostic tools...
October 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28950939/new-insights-into-the-morphology-and-function-of-meibomian-glands
#9
REVIEW
Reiko Arita, Shima Fukuoka, Naoyuki Morishige
Meibomian glands secrete meibum, which gives rise to the lipid layer of the tear film and thereby prevents excessive evaporation of tear fluid. Meibomian gland dysfunction (MGD) is a major causative condition of evaporative dry eye, which is more common than the aqueous-deficient type of dry eye. Noninvasive meibography relies on infrared light and an infrared-sensitive camera to reveal the morphology of meibomian glands in both the upper and lower eyelids, whereas tear interferometry allows both qualitative and quantitative evaluation of the lipid layer of the tear film...
October 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28950938/role-of-egf-receptor-signaling-on-morphogenesis-of-eyelid-and-meibomian-glands
#10
REVIEW
Fei Dong, Mindy Call, Ying Xia, Winston W-Y Kao
The epidermal growth factor receptor (EGFR) signaling has a pivotal role in the regulation of morphogenesis during development and maintenance of homeostasis in adult eyelid and its adnexa. Studies have demonstrated that during eyelid morphogenesis the EGFR signaling pathway is responsible for keratinocyte and mesenchymal cell proliferation and migration at the eyelid tip. For meibomian gland morphogenesis, EGFR signaling activation stimulates meibomian gland epithelial cell proliferation. EGFR signaling pathway functions through multiple downstream signals such as ERK, Rho/ROCK and integrin and is regulated by a variety of upstream signals including Adam17, GPR48 and FGFR signaling...
October 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28950937/function-of-meibomian-gland-contribution-of-proteins
#11
REVIEW
M Vimalin Jeyalatha, Yangluowa Qu, Zhen Liu, Shangkun Ou, Xin He, Jinghua Bu, Sanming Li, Peter Sol Reinach, Zuguo Liu, Wei Li
The meibomian gland is the major contributor to the tear film lipid layer. It is generally accepted that meibomian gland secretions, i.e, meibum, play a critical role in the homeostasis of the tear film. Lipid components of meibum and their structure, as well as functions were intensively studied. However, the proteins from meibum have not attracted enough attention. This review summarizes current knowledge about protein components of the meibum, particularly their function on tear film and ocular surface, and changes in the proteins during meibomian gland dysfunction (MGD)...
October 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28950936/structure-function-relationship-of-tear-film-lipid-layer-a%C3%A2-contemporary-perspective
#12
REVIEW
Georgi As Georgiev, Petar Eftimov, Norihiko Yokoi
Tear film lipid layer (TFLL) stabilizes the air/tear surface of the human eye. Meibomian gland dysfunction (MGD) resulting in quantitative and qualitative modifications of TFLL major (>93%) component, the oily secretion of meibomian lipids (MGS), is the world leading cause of dry eye syndrome (DES) with up to 86% of all DES patients showing signs of MGD. Caused by intrinsic factors (aging, ocular and general diseases) and by extrinsic everyday influences like contact lens wear and extended periods in front of a computer screen, DES (resulting in TF instability, visual disturbances and chronic ocular discomfort) is the major ophthalmic public health disease of the present time affecting the quality of life of 10-30% of the human population worldwide...
October 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28950169/lipidomics-of-equine-amniotic-fluid-identification-of-amphiphilic-o-acyl-%C3%AF-hydroxy-fatty-acids
#13
Paul L Wood, Barry A Ball, Kirsten Scoggin, Mats H Troedsson, Edward L Squires
Amniotic fluid is essential for the growth and maturation of the fetus prior to parturition. While our knowledge of human amniotic fluid is extensive, current data for equine amniotic fluid is limited. We therefore undertook a detailed lipidomics analysis of equine amniotic fluid. Using a non-targeted high-resolution mass spectrometric lipidomics analysis of equine amniotic fluid, we were able to characterize a diverse array of individual lipids. This non-biased analytical approach detected, for the first time, the presence of (O-acyl)-ω-hydroxy-fatty acids (OAHFA) with up to 52 carbon chain lengths in amniotic fluid...
September 20, 2017: Theriogenology
https://www.readbyqxmd.com/read/28939264/the-effects-of-a-hydrating-mask-compared-to-traditional-warm-compresses-on-tear-film-properties-in-meibomian-gland-dysfunction
#14
Jacqueline Tan, Lily Ho, Katherine Wong, Alma La, Sylbi Lee, Sarah Park, Larissa Tran, Fiona Stapleton
No abstract text is available yet for this article.
September 19, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28926885/-evaluation-of-short-term-effect-of-intense-pulsed-light-combined-with-meibomian-gland-expression-in-the-treatment-of-meibomian-gland-dysfunction
#15
B Rong, P Tu, Y Tang, R X Liu, W J Song, X M Yan
Objective: To explore short-term effect of intense pulsed light (IPL) combined with meibomian gland expression in treating meibomian gland dysfunction (MGD). Methods: This study was a prospective, randomized, double-masked, controlled study. Forty-four MGD patients were enrolled in the study and received three consecutive IPL treatments with an interval of 4 weeks. One eye of each patient was randomly assigned as the study eye receiving the IPL therapy with an energy of 14-16 J/cm(2), and the fellow eye was as the control eye receiving a placebo therapy with 0 J/cm(2)...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28922088/semifluorinated-alkane-eye-drops-for-treatment-of-dry-eye-disease-due-to-meibomian-gland-disease
#16
Philipp Steven, Albert J Augustin, Gerd Geerling, Thomas Kaercher, Florian Kretz, Kathleen Kunert, Johannes Menzel-Severing, Norbert Schrage, Wolfgang Schrems, Sonja Krösser, Michael Beckert, Elisabeth M Messmer
PURPOSE: Meibomian gland disease is generally accepted as the leading cause for evaporative dry eye disease (DED). In a previous study, perfluorohexyloctane, a semifluorinated alkane, has been demonstrated to significantly increase tear film breakup time and to reduce corneal fluorescein staining in patients with evaporative DED, thereby vastly reducing dry eye-related symptoms. This study was set up to evaluate perfluorohexyloctane in a larger population of patients with Meibomian gland dysfunction...
September 18, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28922018/tacrolimus-ointment-for-refractory-posterior-blepharitis
#17
Fernando Eiji Sakassegawa-Naves, Helena Maria Moraes Ricci, Bernardo Kaplan Moscovici, Daniela Akemi Miyamoto, Brenda Biagio Chiacchio, Ricardo Holzchuh, Ruth Muyuki Santo, Richard Yudi Hida
PURPOSE: This prospective, randomized, double-blind interventional case series was designed to evaluate the short-term efficacy of 0.03% tacrolimus ointment as a new therapeutic approach for refractory cases of posterior blepharitis. METHODS: Forty eyes (20 patients) with posterior blepharitis refractory to previous treatment were randomized. Eighteen eyes (9 patients) were treated with 0.03% tacrolimus ointment and 20 eyes (10 patients) with placebo ointment twice daily...
November 2017: Current Eye Research
https://www.readbyqxmd.com/read/28910571/factors-that-influence-tear-meniscus-area-and-conjunctivochalasis-the-singapore-indian-eye-study
#18
Stanley Poh, Ryan Lee, Jennifer Gao, Carin Tan, Preeti Gupta, Charumathi Sabanayagam, Ching-Yu Cheng, Tien-Yin Wong, Louis Tong
PURPOSE: Assessment of tear film and conjunctiva is critical to define presence and severity of ocular surface disease. We aimed to characterize tear meniscus area (TMA) and conjunctivochalasis by anterior segment optical coherence tomography (ASOCT) in population-based patients and identify potential factors associated with low TMA and severe conjunctivochalasis. METHODS: Study subjects were enrolled from The Singapore Indian Eye Study, a population-based study of Asian Indian in Singapore...
September 14, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28902017/ocular-demodicosis-as-a-potential-cause-of-ocular-surface-inflammation
#19
Xiaohui Luo, Jing Li, Chuan Chen, Scheffer Tseng, Lingyi Liang
Among different species of mites, Demodex folliculorum and Demodex brevis are the only 2 that affect the human eye. Because demodicosis is highly age-dependent and can be found in asymptomatic adults, the pathogenicity of these mites has long been debated. In this study, we summarize our research experience including our most recent study regarding Demodex infestation as a potential cause of ocular inflammatory diseases. Specifically, we describe the pathogenesis of demodicosis and then discuss the results of work investigating the associations and relationships between ocular demodicosis and blepharitis, meibomian gland diseases, and keratitis, in turn...
November 2017: Cornea
https://www.readbyqxmd.com/read/28902011/meibomian-gland-dysfunction-associated-with-periocular-radiotherapy
#20
Young Jun Woo, JaeSang Ko, Yong Woo Ji, Tae-Im Kim, Jin Sook Yoon
PURPOSE: To investigate the influence of periocular radiotherapy on meibomian glands. METHODS: We evaluated 28 patients (40 eyes) who received radiotherapy (RT group) for conjunctival or orbital lymphoma and 30 age-matched control subjects (60 eyes). Subjects underwent slit-lamp examination of the eyelids, Schirmer test, meibography, and evaluation of tear film breakup time (TBUT), Ocular Surface Disease Index (OSDI) scores, meibomian glands evaluation (meiboscore, meibum expressibility, and lid margin abnormality scores), and tear film lipid layer thickness using an ocular surface interferometer...
September 8, 2017: Cornea
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