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Cornea collagen crosslinking

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https://www.readbyqxmd.com/read/28192838/topography-guided-prk-and-crosslinking-in-eyes-with-keratoconus-and-post-lasik-ectasia
#1
T M Müller, A P Lange
Topography-guided photorefractive keratectomy (TG-PRK) combined with corneal collagen crosslinking (CXL) has been shown to potentially improve vision and stabilize progression in patients with keratoconus (KC). We attempted to reproduce the previously published results using a different laser platform (AMARIS 500E) in patients with KC and post-LASIK ectasia (PLE). All of the 9 included eyes showed improved topography (Kmax, Kmean, RMS HOA, vertical coma, cylinder; p < 0.05) and improved visual acuity (BCVA, UCVA; p < 0...
February 13, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28101423/assessing-the-effects-of-riboflavin-uv-a-crosslinking-on-porcine-corneal-mechanical-anisotropy-with-optical-coherence-elastography
#2
Manmohan Singh, Jiasong Li, Zhaolong Han, Raksha Raghunathan, Achuth Nair, Chen Wu, Chih-Hao Liu, Salavat Aglyamov, Michael D Twa, Kirill V Larin
In this work we utilize optical coherence elastography (OCE) to assess the effects of UV-A/riboflavin corneal collagen crosslinking (CXL) on the mechanical anisotropy of in situ porcine corneas at various intraocular pressures (IOP). There was a distinct meridian of increased Young's modulus in all samples, and the mechanical anisotropy increased as a function of IOP and also after CXL. The presented noncontact OCE technique was able to quantify the Young's modulus and elastic anisotropy of the cornea and their changes as a function of IOP and CXL, opening new avenues of research for evaluating the effects of CXL on corneal biomechanical properties...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28055099/evaluation-of-therapeutic-tissue-crosslinking-txl-for-myopia-using-second-harmonic-generation-signal-microscopy-in-rabbit-sclera
#3
Mariya Zyablitskaya, Anna Takaoka, Emilia L Munteanu, Takayuki Nagasaki, Stephen L Trokel, David C Paik
Purpose: Second harmonic generation signals (SHG) are emitted preferentially from collagenous tissue structures and have been used to evaluate photochemically-induced (CXL) crosslinking changes in the cornea. Since therapeutic tissue crosslinking (TXL) using sodium hydroxymethylglycinate (SMG) of the sclera is a potential treatment for high myopia, we explored the use of SHG microscopy to evaluate the effects. Methods: Single sub-Tenon's (sT) injections (400 μL) using SMG (40-400 mM) were made at the equatorial 12 o'clock position of the right eye of cadaveric rabbit heads (n = 16 pairs)...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27956294/nonlinear-optical-corneal-collagen-crosslinking-of-ex%C3%A2-vivo-rabbit-eyes
#4
Samantha M Bradford, Donald J Brown, Tibor Juhasz, Eric Mikula, James V Jester
PURPOSE: To determine whether riboflavin-induced collagen crosslinking (CXL) could be precisely achieved in the corneal stroma of ex vivo rabbit eyes using nonlinear optical excitation with a low numerical aperture lens and enlarged focal volume. SETTING: Gavin Herbert Eye Institute, University of California Irvine, Irvine, California, USA. DESIGN: Experimental study. METHODS: The corneal epithelium was removed and the corneas were soaked in 0...
November 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27926752/corneal-resistance-to-keratolysis-after-collagen-crosslinking-with-rose-bengal-and-green-light
#5
Ali Fadlallah, Hong Zhu, Samer Arafat, Irene Kochevar, Samir Melki, Joseph B Ciolino
Purpose: The purpose of this study was to evaluate the resistance to degradation by collagenase A of corneas that have been crosslinked with Rose Bengal and green light (RGX). Methods: The ex vivo crosslinking procedure was performed on enucleated rabbit corneas. Corneas were deepithelialized after applying 30% alcohol. Corneas were stained with Rose Bengal (RB, 0.1%) for 2 minutes and then exposed to green light (532 nm) at 0.25 W/cm2 for times to deliver doses of 50, 100, 150, or 200 J/cm2 (n = 5 per group)...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27710923/in-vitro-characterization-of-electrochemically-compacted-collagen-matrices-for-corneal-applications
#6
Vipuil Kishore, Ranjani Iyer, Athela Frandsen, Thuy-Uyen Nguyen
Loss of vision due to corneal disease is a significant problem worldwide. Transplantation of donor corneas is a viable treatment option but limitations such as short supply and immune-related complications call for alternative options for the treatment of corneal disease. A tissue engineering-based approach using a collagen scaffold is a promising alternative to develop a bioengineered cornea that mimics the functionality of native cornea. In this study, an electrochemical compaction method was employed to synthesize highly dense and transparent collagen matrices...
October 6, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27547022/noncontact-elastic-wave-imaging-optical-coherence-elastography-for-evaluating-changes-in-corneal-elasticity-due-to-crosslinking
#7
Manmohan Singh, Jiasong Li, Srilatha Vantipalli, Shang Wang, Zhaolong Han, Achuth Nair, Salavat R Aglyamov, Michael D Twa, Kirill V Larin
The mechanical properties of tissues can provide valuable information about tissue integrity and health and can assist in detecting and monitoring the progression of diseases such as keratoconus. Optical coherence elastography (OCE) is a rapidly emerging technique, which can assess localized mechanical contrast in tissues with micrometer spatial resolution. In this work we present a noncontact method of optical coherence elastography to evaluate the changes in the mechanical properties of the cornea after UV-induced collagen cross-linking...
May 2016: IEEE Journal of Selected Topics in Quantum Electronics
https://www.readbyqxmd.com/read/27492105/natural-history-of-corneal-haze-after-corneal-collagen-crosslinking-in-keratoconus-using-scheimpflug-analysis
#8
Bia Z Kim, Charlotte A Jordan, Charles N J McGhee, Dipika V Patel
PURPOSE: To analyze corneal haze after corneal collagen crosslinking (CXL) for progressive keratoconus using Scheimpflug densitometry. SETTING: Auckland District Health Board, Auckland, New Zealand. DESIGN: Prospective randomized controlled study. METHODS: Both eyes of all patients were examined preoperatively and 1, 3, 6, and 12 months postoperatively. One eye of each patient was treated with corneal CXL, with the contralateral eye serving as the control...
July 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27463630/the-effects-of-riboflavin-and-ultraviolet-light-on-keratocytes-cultured-in-vitro
#9
Joyce L Covre, Priscila C Cristovam, Renata R Loureiro, Rossen M Hazarbassanov, Mauro Campos, Élcio H Sato, José Álvaro P Gomes
PURPOSE: To culture quiescent human keratocytes and evaluate the effects of ultraviolet light and riboflavin on human corneal keratocytes in vitro. METHODS: Keratocytes were obtained from remaining corneoscleral ring donor corneas previously used in corneal transplant surgeries and cultured in DMEM/F12 with 2% FBS until confluence. Characterization of cultured cells was performed by immunofluorescence analysis for anti-cytokeratin-3, anti-Thy-1, anti-α-smooth muscle actin, and anti-lumican...
May 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27220229/collagen-crosslinking-in-the-management-of-microbial-keratitis
#10
Barac Ileana Ramona, Corbu Catalina, Merticariu Andrei, Stefan Daciana, Tataru Calin
OBJECTIVE: The evaluation of the efficiency of corneal cross linking in the management of corneal ulcers. METHOD: A prospective study that included 10 patients, 10 eyes, with chronic corneal ulcer, bacterial and/ or fungal. The patients were divided into two groups. Group A included 5 patients with unperforated corneal ulcer and group B included 5 patients with perforated corneal ulcer. These patients were treated with general and local antibiotic and antifungal drugs, but the response was poor after two weeks...
January 2016: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27113884/intraoperative-corneal-thickness-change-and-clinical-outcomes-after-corneal-collagen-crosslinking-standard-crosslinking-versus-hypotonic-riboflavin
#11
Elan Rosenblat, Peter S Hersh
PURPOSE: To determine intraoperative changes in corneal thickness and outcomes of corneal collagen crosslinking (CXL) using 2 intraoperative regimens: riboflavin-dextran or hypotonic riboflavin. SETTING: Cornea and refractive surgery practice, Teaneck, New Jersey, USA. DESIGN: Prospective randomized case series. METHODS: Eyes with keratoconus or corneal ectasia were treated. All eyes received preloading with riboflavin 0...
April 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27097560/outcomes-of-corneal-collagen-crosslinking-using-a-customized-epithelial-debridement-technique-in-keratoconic-eyes-with-thin-corneas
#12
Nurullah Cagil, Ozge Sarac, Gamze Dereli Can, Emine Akcay, Mehmet Erol Can
The purpose of the study was to evaluate the outcomes and possible complications of CXL performed with customized epithelial debridement technique to keratoconic corneas with the thinnest pachymetry values less than 400 µm. Nineteen eyes of 19 patients were included. The uncorrected (UCVA) and best corrected visual acuity (BCVA), flattest and steepest keratometric (K) readings, central corneal thickness at the thinnest point (t-CCT), endothelial cell density (ECD) were assessed before and 12 months after CXL...
February 2017: International Ophthalmology
https://www.readbyqxmd.com/read/26650390/three-different-protocols-of-corneal-collagen-crosslinking-in-keratoconus-conventional-accelerated-and-iontophoresis
#13
Nacim Bouheraoua, Lea Jouve, Vincent Borderie, Laurent Laroche
Keratoconus is a bilateral and progressive corneal ectasia. In order to slow down its progression, corneal collagen cross-linking (CXL) has recently been introduced as an efficient treatment option. In biological and chemical sciences, crosslinking refers to new chemical bonds formed between reactive molecules. Hence, the aim of corneal collagen CXL is to synthetically increase the formation of crosslinks between collagen fibrils in the corneal stroma. Despite the fact that the efficiency of the conventional CXL (C-CXL) protocol has already been shown in several clinical studies, it might benefit from improvements in duration of the procedure and removal of corneal epithelium...
November 12, 2015: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/26622139/microbial-keratitis-following-accelerated-corneal-collagen-cross-linking
#14
Shreesha Kumar Kodavoor, Nikit J Sarwate, D Ramamurhy
A deep stromal infiltrate with hypopyon appeared in central cornea of right eye of a 15-year-old boy postoperatively after 2 days, who underwent uneventful accelerated corneal collagen crosslinking (C3R) with riboflavin and ultraviolet-A (UVA) for the treatment of keratoconus. Staphylococcus aureus keratitis was confirmed by the microbiological studies, which guided intense treatment with topical and systemic antibiotics. Before C3R, the best corrected visual acuity (BCVA) in the ocular dexter was 20/30 with the refraction of - 1...
May 2015: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/26622089/intraocular-pressure-measurements-referring-to-the-corneal-thickness-in-keratoconic-eyes-after-corneal-crosslinking-with-riboflavin-and-ultraviolet-a
#15
Sanja Sefic Kasumovic, Milka Mavija, Aida Kasumovic, Orhan Lepara, Belkisa Duric-Colic, Emir Cabric, Lejla Muhamedagic, Adisa Sakovic-Racic, Mirko Jankov
AIM: To determine the possible relation between intraocular pressure (IOP), central corneal thickness (CCT) and corneal resistance (CR) in kerotoconic eyes before, 3,6 and 12 months after collagen crosslinking procedure (CXL) with aim to find out does the thicker cornea means already more resistance cornea followed with higher IOP. METHODS: Thirty eyes (30 patients) with central keratoconus (KC)were evaluated in retrospective cross sectional study. The corneal biomechanical parameters were taken with Wave Light Allegro Oculyzer produced by Alcon before the CXL, 3, 6 and 12 months after the procedure...
October 2015: Medical Archives
https://www.readbyqxmd.com/read/26603408/standard-versus-accelerated-riboflavin-ultraviolet-corneal-collagen-crosslinking-resistance-against-enzymatic-digestion
#16
Nada H Aldahlawi, Sally Hayes, David P S O'Brart, Keith M Meek
PURPOSE: To examine the effect of standard and accelerated corneal collagen crosslinking (CXL) on corneal enzymatic resistance. SETTING: School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom. DESIGN: Experimental study. METHODS: Sixty-six enucleated porcine eyes (with corneal epithelium removed) were assigned to 6 groups. Group 1 remained untreated, group 2 received dextran eyedrops, and groups 3 to 6 received riboflavin/dextran eyedrops...
September 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26325407/protective-effects-of-soluble-collagen-during-ultraviolet-a-crosslinking-on-enzyme-mediated-corneal-ectatic-models
#17
Xiaokun Wang, Yong Huang, Sabah Jastaneiah, Shoumyo Majumdar, Jin U Kang, Samuel C Yiu, Walter Stark, Jennifer H Elisseeff
Collagen crosslinking is a relatively new treatment for structural disorders of corneal ectasia, such as keratoconus. However, there is a lack of animal models of keratoconus, which has been an obstacle for carefully analyzing the mechanisms of crosslinking and evaluating new therapies. In this study, we treated rabbit eyes with collagenase and chondroitinase enzymes to generate ex vivo corneal ectatic models that simulate the structural disorder of keratoconus. The models were then used to evaluate the protective effect of soluble collagen in the UVA crosslinking system...
2015: PloS One
https://www.readbyqxmd.com/read/26105541/long-term-results-of-corneal-collagen-crosslinking-for-progressive-keratoconus
#18
Maddalena De Bernardo, Luigi Capasso, Michele Lanza, Antonia Tortori, Stefania Iaccarino, Michela Cennamo, Maria Borrelli, Nicola Rosa
PURPOSE: To evaluate long-term keratoconus stability after corneal crosslinking (CXL) with riboflavin. METHODS: In this prospective study, 57 eyes of 55 patients with progressive keratoconus, consecutively treated with ultraviolet A (UVA) - riboflavin CXL, were examined with the corneal topographer Pentacam, the biometer IOLMaster and the analyzer of corneal biomechanics Ocular Response Analyzer before and during a 24 months follow-up after CXL. RESULTS: Twenty-four months after CXL, there was a significant improvement in best corrected visual acuity (BCVA) (P<0...
July 2015: Journal of Optometry
https://www.readbyqxmd.com/read/26044373/variability-of-different-reference-bodies-in-normal-keratoconus-and-collagen-crosslinked-corneas
#19
Georgios Labiris, Athanassios Giarmoukakis, Alexandros Rampotas, Maria Symeou, Panagiota Bougatsou, Haris Sideroudi, Vassilios P Kozobolis
PURPOSE: To evaluate the reproducibility of different Scheimpflug imaging-derived reference bodies in normal, keratoconus (KC), and crosslinked (CXL) eyes. METHODS: In this prospective, observational study, 40 participants populated the control group (CG), while 33 and 34 patients formed the KC group and the CXL group, respectively. One eye was randomly selected when both were eligible. Elevation measurements were obtained using Scheimpflug camera, by applying the following reference bodies: the best fit sphere (BFS), the best fit toric ellipsoid (BFTE), the best fit toric ellipsoid with fixed eccentricity of 0...
November 2015: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/25997682/-predictive-factors-for-visual-outcome-after-corneal-collagen-crosslinking-treatment-in-progressive-keratoconus-one-year-refractive-and-topographic-results
#20
F De Angelis, J Rateau, C Destrieux, F Patat, P-J Pisella
PURPOSE: To assess the effects of preoperative patient characteristics on clinical outcomes of corneal collagen crosslinking (CXL) in patients with progressive keratoconus. PATIENTS AND METHODS: Fifty-four eyes of 41 patients underwent CXL for progressive keratoconus between June 2011 and December 2012. Corneal topography (Orbscan(®)) was assessed at 1, 3, and 6 months and 1 year after CXL treatment and compared with preoperative data. RESULTS: A significant improvement in 1-year postoperative best-corrected visual acuity (BCVA) (0...
September 2015: Journal Français D'ophtalmologie
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