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Cornea collagen crosslinking

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https://www.readbyqxmd.com/read/28393024/biomechanics-of-sclera-crosslinked-using-genipin-in-rabbit
#1
Tai-Xiang Liu, Zheng Wang
AIM: To strengthen the biomechanics of collagen by crosslinking rabbit scleral collagen with genipin to develop a new therapy for preventing myopic progression. METHODS: Ten New Zealand rabbits were treated with 0.5 mmol/L genipin injected into the sub-Tenon's capsule in the right eyes. Untreated contralateral eyes served as the control. The treated area was cut into scleral strips measuring 4.0 mm×10.0 mm for stress-strain measurements (n=5). The remaining five treated eyes were prepared for histological examination...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28392939/thinner-corneas-appear-to-have-more-striking-effects-of-corneal-collagen-crosslinking-in-patients-with-progressive-keratoconus
#2
Yunfei Han, Yanyun Xu, Wei Zhu, Yuling Liu, Zhen Liu, Xiaoxiao Dou, Guoying Mu
Purpose. To analyze the outcomes and difference after UVA/riboflavin corneal collagen crosslinking (CXL) in four different corneal thickness groups of patients with progressive keratoconus. Methods. Retrospective study. Eyes with progressive keratoconus after CXL were divided into 4 subgroups as follows: group 1, thinnest corneal thickness (TCT) ≤ 400 µm; group 2, 400 µm < TCT ≤ 450 µm; group 3, 450 µm < TCT ≤ 500 µm; group 4, TCT ≥ 500 µm. Baseline, 6-month, and 12-month visual acuity, corneal topography, TCT, and endothelial cell density were evaluated...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28384251/modeling-the-efficacy-profiles-of-uv-light-activated-corneal-collagen-crosslinking
#3
Jui-Teng Lin, Da-Chuan Cheng
OBJECTIVE: Analysis of the crosslink time, depth and efficacy profiles of UV-light-activated corneal collagen crosslinking (CXL). METHODS: A modeling system described by a coupled dynamic equations are numerically solved and analytic formulas are derived for the crosslinking time (T*) and crosslinking depth (z*). The z-dependence of the CXL efficacy is numerically produced to show the factors characterizing the profiles. RESULTS: Optimal crosslink depth (z*) and maximal CXL efficacy (Ceff) have opposite trend with respective to the UV light intensity and RF concentration, where z* is a decreasing function of the riboflavin concentration (C0)...
2017: PloS One
https://www.readbyqxmd.com/read/28366375/measuring-the-depth-of-crosslinking-demarcation-line-in%C3%A2-vivo-comparison-of-methods-and-devices
#4
Andreas Thorsrud, Gunhild F Sandvik, Anne M Hagem, Liv Drolsum
PURPOSE: To assess the interrelationship of different methods of measuring the demarcation line depth after corneal collagen crosslinking (CXL). SETTING: University eye clinic, Oslo, Norway. DESIGN: Prospective case series. METHODS: Eyes having CXL for progressive keratoconus were evaluated 1 month after CXL by in vitro confocal microscopy (IVCM), optical coherence tomography (OCT), and Scheimpflug imaging. When applying IVCM, the depth of the CXL demarcation line was measured with 2 methods; that is, IVCM keratocyte disappearance and IVCM intensity increase...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28317666/transepithelial-crosslinking-retreatment-of-progressive-corneal-ectasia-unresponsive-to-classic-crosslinking
#5
Roy S Rubinfeld, Rachel H Epstein, Parag A Majmudar, Deborah Kim, Michael Choi, Randy J Epstein
A 41-year-old man presented 10 years after uneventful laser in situ keratomileusis (LASIK) with symptomatic post-LASIK ectasia. He had treatment with the classic Dresden epithelium-off technique and presented 4 years later with progression of the ectasia. He was subsequently retreated with conductive keratoplasty (CK) followed by a new proprietary epithelium-on corneal collagen crosslinking (CXL) procedure using a proprietary transepithelial riboflavin formulation and delivery system on the following day...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28272223/outcomes-of-corneal-crosslinking-for-central-and-paracentral-keratoconus
#6
COMPARATIVE STUDY
Mingxia Tian, Ping Ma, Weiyan Zhou, Jie Feng, Guoying Mu
BACKGROUND: The aim of the study was to compare the therapy of corneal collagen crosslinking (CXL) for central and paracentral keratoconus. METHODS: 64 eyes of 43 central keratoconus patients whose highest power of the cornea located in the central 3 mm zone and 24 eyes of 16 paracentral keratoconus patients whose highest power located out of the central 3 mm zone received standard corneal CXL were included. Maximum keratometry (Kmax) and astigmatism according to topography, uncorrected distant visual acuity (UDVA), corrected distant visual acuity (CDVA) were studied preoperatively and 2 years postoperatively...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28192838/topography-guided-prk-and-crosslinking-in-eyes-with-keratoconus-and-post-lasik-ectasia
#7
T M Müller, A P Lange
Topography-guided photorefractive keratectomy (TG-PRK) combined with corneal collagen crosslinking (CXL) has been shown to potentially improve vision and stabilize progression in patients with keratoconus (KC). We attempted to reproduce the previously published results using a different laser platform (AMARIS 500E) in patients with KC and post-LASIK ectasia (PLE). All of the 9 included eyes showed improved topography (Kmax, Kmean, RMS HOA, vertical coma, cylinder; p < 0.05) and improved visual acuity (BCVA, UCVA; p < 0...
February 13, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28101423/assessing-the-effects-of-riboflavin-uv-a-crosslinking-on-porcine-corneal-mechanical-anisotropy-with-optical-coherence-elastography
#8
Manmohan Singh, Jiasong Li, Zhaolong Han, Raksha Raghunathan, Achuth Nair, Chen Wu, Chih-Hao Liu, Salavat Aglyamov, Michael D Twa, Kirill V Larin
In this work we utilize optical coherence elastography (OCE) to assess the effects of UV-A/riboflavin corneal collagen crosslinking (CXL) on the mechanical anisotropy of in situ porcine corneas at various intraocular pressures (IOP). There was a distinct meridian of increased Young's modulus in all samples, and the mechanical anisotropy increased as a function of IOP and also after CXL. The presented noncontact OCE technique was able to quantify the Young's modulus and elastic anisotropy of the cornea and their changes as a function of IOP and CXL, opening new avenues of research for evaluating the effects of CXL on corneal biomechanical properties...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28055099/evaluation-of-therapeutic-tissue-crosslinking-txl-for-myopia-using-second-harmonic-generation-signal-microscopy-in-rabbit-sclera
#9
Mariya Zyablitskaya, Anna Takaoka, Emilia L Munteanu, Takayuki Nagasaki, Stephen L Trokel, David C Paik
Purpose: Second harmonic generation signals (SHG) are emitted preferentially from collagenous tissue structures and have been used to evaluate photochemically-induced (CXL) crosslinking changes in the cornea. Since therapeutic tissue crosslinking (TXL) using sodium hydroxymethylglycinate (SMG) of the sclera is a potential treatment for high myopia, we explored the use of SHG microscopy to evaluate the effects. Methods: Single sub-Tenon's (sT) injections (400 μL) using SMG (40-400 mM) were made at the equatorial 12 o'clock position of the right eye of cadaveric rabbit heads (n = 16 pairs)...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27956294/nonlinear-optical-corneal-collagen-crosslinking-of-ex%C3%A2-vivo-rabbit-eyes
#10
Samantha M Bradford, Donald J Brown, Tibor Juhasz, Eric Mikula, James V Jester
PURPOSE: To determine whether riboflavin-induced collagen crosslinking (CXL) could be precisely achieved in the corneal stroma of ex vivo rabbit eyes using nonlinear optical excitation with a low numerical aperture lens and enlarged focal volume. SETTING: Gavin Herbert Eye Institute, University of California Irvine, Irvine, California, USA. DESIGN: Experimental study. METHODS: The corneal epithelium was removed and the corneas were soaked in 0...
November 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27926752/corneal-resistance-to-keratolysis-after-collagen-crosslinking-with-rose-bengal-and-green-light
#11
Ali Fadlallah, Hong Zhu, Samer Arafat, Irene Kochevar, Samir Melki, Joseph B Ciolino
Purpose: The purpose of this study was to evaluate the resistance to degradation by collagenase A of corneas that have been crosslinked with Rose Bengal and green light (RGX). Methods: The ex vivo crosslinking procedure was performed on enucleated rabbit corneas. Corneas were deepithelialized after applying 30% alcohol. Corneas were stained with Rose Bengal (RB, 0.1%) for 2 minutes and then exposed to green light (532 nm) at 0.25 W/cm2 for times to deliver doses of 50, 100, 150, or 200 J/cm2 (n = 5 per group)...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27710923/in-vitro-characterization-of-electrochemically-compacted-collagen-matrices-for-corneal-applications
#12
Vipuil Kishore, Ranjani Iyer, Athela Frandsen, Thuy-Uyen Nguyen
Loss of vision due to corneal disease is a significant problem worldwide. Transplantation of donor corneas is a viable treatment option but limitations such as short supply and immune-related complications call for alternative options for the treatment of corneal disease. A tissue engineering-based approach using a collagen scaffold is a promising alternative to develop a bioengineered cornea that mimics the functionality of native cornea. In this study, an electrochemical compaction method was employed to synthesize highly dense and transparent collagen matrices...
October 6, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27547022/noncontact-elastic-wave-imaging-optical-coherence-elastography-for-evaluating-changes-in-corneal-elasticity-due-to-crosslinking
#13
Manmohan Singh, Jiasong Li, Srilatha Vantipalli, Shang Wang, Zhaolong Han, Achuth Nair, Salavat R Aglyamov, Michael D Twa, Kirill V Larin
The mechanical properties of tissues can provide valuable information about tissue integrity and health and can assist in detecting and monitoring the progression of diseases such as keratoconus. Optical coherence elastography (OCE) is a rapidly emerging technique, which can assess localized mechanical contrast in tissues with micrometer spatial resolution. In this work we present a noncontact method of optical coherence elastography to evaluate the changes in the mechanical properties of the cornea after UV-induced collagen cross-linking...
May 2016: IEEE Journal of Selected Topics in Quantum Electronics
https://www.readbyqxmd.com/read/27492105/natural-history-of-corneal-haze-after-corneal-collagen-crosslinking-in-keratoconus-using-scheimpflug-analysis
#14
Bia Z Kim, Charlotte A Jordan, Charles N J McGhee, Dipika V Patel
PURPOSE: To analyze corneal haze after corneal collagen crosslinking (CXL) for progressive keratoconus using Scheimpflug densitometry. SETTING: Auckland District Health Board, Auckland, New Zealand. DESIGN: Prospective randomized controlled study. METHODS: Both eyes of all patients were examined preoperatively and 1, 3, 6, and 12 months postoperatively. One eye of each patient was treated with corneal CXL, with the contralateral eye serving as the control...
July 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27463630/the-effects-of-riboflavin-and-ultraviolet-light-on-keratocytes-cultured-in-vitro
#15
Joyce L Covre, Priscila C Cristovam, Renata R Loureiro, Rossen M Hazarbassanov, Mauro Campos, Élcio H Sato, José Álvaro P Gomes
PURPOSE: To culture quiescent human keratocytes and evaluate the effects of ultraviolet light and riboflavin on human corneal keratocytes in vitro. METHODS: Keratocytes were obtained from remaining corneoscleral ring donor corneas previously used in corneal transplant surgeries and cultured in DMEM/F12 with 2% FBS until confluence. Characterization of cultured cells was performed by immunofluorescence analysis for anti-cytokeratin-3, anti-Thy-1, anti-α-smooth muscle actin, and anti-lumican...
May 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27220229/collagen-crosslinking-in-the-management-of-microbial-keratitis
#16
Barac Ileana Ramona, Corbu Catalina, Merticariu Andrei, Stefan Daciana, Tataru Calin
OBJECTIVE: The evaluation of the efficiency of corneal cross linking in the management of corneal ulcers. METHOD: A prospective study that included 10 patients, 10 eyes, with chronic corneal ulcer, bacterial and/ or fungal. The patients were divided into two groups. Group A included 5 patients with unperforated corneal ulcer and group B included 5 patients with perforated corneal ulcer. These patients were treated with general and local antibiotic and antifungal drugs, but the response was poor after two weeks...
January 2016: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27113884/intraoperative-corneal-thickness-change-and-clinical-outcomes-after-corneal-collagen-crosslinking-standard-crosslinking-versus-hypotonic-riboflavin
#17
Elan Rosenblat, Peter S Hersh
PURPOSE: To determine intraoperative changes in corneal thickness and outcomes of corneal collagen crosslinking (CXL) using 2 intraoperative regimens: riboflavin-dextran or hypotonic riboflavin. SETTING: Cornea and refractive surgery practice, Teaneck, New Jersey, USA. DESIGN: Prospective randomized case series. METHODS: Eyes with keratoconus or corneal ectasia were treated. All eyes received preloading with riboflavin 0...
April 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27097560/outcomes-of-corneal-collagen-crosslinking-using-a-customized-epithelial-debridement-technique-in-keratoconic-eyes-with-thin-corneas
#18
Nurullah Cagil, Ozge Sarac, Gamze Dereli Can, Emine Akcay, Mehmet Erol Can
The purpose of the study was to evaluate the outcomes and possible complications of CXL performed with customized epithelial debridement technique to keratoconic corneas with the thinnest pachymetry values less than 400 µm. Nineteen eyes of 19 patients were included. The uncorrected (UCVA) and best corrected visual acuity (BCVA), flattest and steepest keratometric (K) readings, central corneal thickness at the thinnest point (t-CCT), endothelial cell density (ECD) were assessed before and 12 months after CXL...
February 2017: International Ophthalmology
https://www.readbyqxmd.com/read/26650390/three-different-protocols-of-corneal-collagen-crosslinking-in-keratoconus-conventional-accelerated-and-iontophoresis
#19
Nacim Bouheraoua, Lea Jouve, Vincent Borderie, Laurent Laroche
Keratoconus is a bilateral and progressive corneal ectasia. In order to slow down its progression, corneal collagen cross-linking (CXL) has recently been introduced as an efficient treatment option. In biological and chemical sciences, crosslinking refers to new chemical bonds formed between reactive molecules. Hence, the aim of corneal collagen CXL is to synthetically increase the formation of crosslinks between collagen fibrils in the corneal stroma. Despite the fact that the efficiency of the conventional CXL (C-CXL) protocol has already been shown in several clinical studies, it might benefit from improvements in duration of the procedure and removal of corneal epithelium...
November 12, 2015: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/26622139/microbial-keratitis-following-accelerated-corneal-collagen-cross-linking
#20
Shreesha Kumar Kodavoor, Nikit J Sarwate, D Ramamurhy
A deep stromal infiltrate with hypopyon appeared in central cornea of right eye of a 15-year-old boy postoperatively after 2 days, who underwent uneventful accelerated corneal collagen crosslinking (C3R) with riboflavin and ultraviolet-A (UVA) for the treatment of keratoconus. Staphylococcus aureus keratitis was confirmed by the microbiological studies, which guided intense treatment with topical and systemic antibiotics. Before C3R, the best corrected visual acuity (BCVA) in the ocular dexter was 20/30 with the refraction of - 1...
May 2015: Oman Journal of Ophthalmology
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