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IBD and neuroimaging

Jui-Yang Hong, Jennifer S Labus, Zhiguo Jiang, Cody Ashe-Mcnalley, Ivo Dinov, Arpana Gupta, Yonggang Shi, Jean Stains, Nuwanthi Heendeniya, Suzanne R Smith, Kirsten Tillisch, Emeran A Mayer
Regional cortical thickness alterations have been reported in many chronic inflammatory and painful conditions, including inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS), even though the mechanisms underlying such neuroplastic changes remain poorly understood. In order to better understand the mechanisms contributing to grey matter changes, the current study sought to identify the differences in regional alterations in cortical thickness between healthy controls and two chronic visceral pain syndromes, with and without chronic gut inflammation...
2014: PloS One
Laïla Benjilali, Saadia Aidi, Hanane El Mansouri, Maria Benabdejlil, Mohamed Jiddane, Mostafa El Alaoui Faris
Cerebrovenous thrombosis is quite rare in infammatory bowel disease. There are only a few reports of this association in the literature. We report 2 cases of patients with Crohn's disease (CD) who developed cerebral thrombophlebitis confirmed by neuroimaging. The first case was a 35-year-old man with a history of CD who presented with acute confusion. Brain magnetic resonance imaging demonstrated a left temporoparietal infarction and thrombosis of the left lateral sinus. Coagulation studies showed a marked protein S deficiency...
November 2011: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
A R Barclay, J M Keightley, I Horrocks, V Garrick, P McGrogan, R K Russell
BACKGROUND: There is a recognized association between pediatric inflammatory bowel disease (IBD) and cerebral thromboembolic events (CTEs). Historical reporting had described the association as strongest between ulcerative colitis (UC), rather than Crohn's disease (CD). We describe the incidence and outcome of CTE in pediatric IBD patients from a single center over 5 years and the relative proportion of stroke reported in the literature in patients with UC and CD before and after January 2000...
April 2010: Inflammatory Bowel Diseases
M Cappa, S Loche
Growth is one of the most important indicators of child's well-being. The growth pattern is the result of the complex interaction between genetic and environment factors. The gold standard for the diagnosis of GH-deficient (GHD) children is not yet defined. In this review we focused on sensitivity and specificity of the commonly used test for GH secretion and neuroimaging evaluation. Initially, accurate determinations of height, weight, head circumferences and growth velocity should be performed and plotted on an appropriate growth chart...
2003: Journal of Endocrinological Investigation
P A Anton, F Shanahan
The chronic inflammatory bowel diseases (BID), Crohn's disease and ulcerative colitis, are characterized by recurrent periods of inflammation and tissue destruction. The clinical course is influenced by genetics, environmental factors, and the immune system. Recent insights (bench trials) benefiting from advances in genetic engineering and molecular biology have contributed to clinical care (bedside) in terms of actual or potential therapies. Does the neuroendocrine system significantly modify disease activity? Although conceptually appealing, evidence remains circumstantial...
May 1, 1998: Annals of the New York Academy of Sciences
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