keyword
https://read.qxmd.com/read/38332859/altered-resting-state-brain-functional-activities-and-networks-in-crohn-s-disease-a-systematic-review
#1
Ling Yang, Peipei He, Lingqin Zhang, Kang Li
BACKGROUND: Crohn's disease (CD) is a non-specific chronic inflammatory disease of the gastrointestinal tract and is a phenotype of inflammatory bowel disease (IBD). The current study sought to compile the resting-state functional differences in the brain between CD patients and healthy controls. METHODS: The online databases PubMed, Web of Science Core, and EMBASE were used to find the published neuroimage studies. The search period was from the beginning through December 15, 2023...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38025434/brain-signatures-of-chronic-gut-inflammation
#2
JOURNAL ARTICLE
Caitlin V Hall, Graham Radford-Smith, Emma Savage, Conor Robinson, Luca Cocchi, Rosalyn J Moran
Gut inflammation is thought to modify brain activity and behaviour via modulation of the gut-brain axis. However, how relapsing and remitting exposure to peripheral inflammation over the natural history of inflammatory bowel disease (IBD) contributes to altered brain dynamics is poorly understood. Here, we used electroencephalography (EEG) to characterise changes in spontaneous spatiotemporal brain states in Crohn's Disease (CD) ( n  = 40) and Ulcerative Colitis (UC) ( n  = 30), compared to healthy individuals ( n  = 28)...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/37797750/altered-voxel-based-and-surface-based-morphometry-in-inflammatory-bowel-disease
#3
JOURNAL ARTICLE
Jennifer Kornelsen, Theresa McIver, Md Nasir Uddin, Chase R Figley, Ruth Ann Marrie, Ronak Patel, John D Fisk, Sean Carter, Lesley Graff, Erin L Mazerolle, Charles N Bernstein
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is characterized by inflammation of the gastrointestinal tract and is a disorder of the brain-gut axis. Neuroimaging studies of brain function and structure have helped better understand the relationships between the brain, gut, and comorbidity in IBD. Studies of brain structure have primarily employed voxel-based morphometry to measure grey matter volume and surface-based morphometry to measure cortical thickness...
October 3, 2023: Brain Research Bulletin
https://read.qxmd.com/read/37530546/the-role-of-neurotransmitters-in-mediating-the-relationship-between-brain-alterations-and-depressive-symptoms-in-patients-with-inflammatory-bowel-disease
#4
JOURNAL ARTICLE
Jun Wang, Guangyao Liu, Kun Xu, Kai Ai, Wenjing Huang, Jing Zhang
A growing body of evidence from neuroimaging studies suggests that inflammatory bowel disease (IBD) is associated with functional and structural alterations in the central nervous system and that it has a potential link to emotional symptoms, such as anxiety and depression. However, the neurochemical underpinnings of depression symptoms in IBD remain unclear. We hypothesized that changes in cortical gamma-aminobutyric acid (GABA+) and glutamine (Glx) concentrations are related to cortical thickness and resting-state functional connectivity in IBD as compared to healthy controls...
August 2, 2023: Human Brain Mapping
https://read.qxmd.com/read/36897213/differential-brain-structural-and-functional-patterns-in-crohn-s-disease-patients-are-associated-with-different-disease-stages
#5
JOURNAL ARTICLE
Alessandro Agostini, Francesca Benuzzi, Daniela Ballotta, Fernando Rizzello, Paolo Gionchetti, Nicola Filippini
BACKGROUND: Crohn's disease (CD) is an inflammatory, chronic disorder that alternates between a quiescent phase and inflammatory flare-ups. Research has begun to elucidate the impact of CD in modulating brain structure and function. The previous neuroimaging studies mainly involved CD patients in remission (CD-R); therefore, little is known about how inflammation influences brain-related features in different stages of the disease. We carried out a magnetic resonance imaging (MRI) study to explore whether the different levels of disease activity may differentially affect brain structure and function...
March 10, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/36333367/prevalence-of-cerebrovascular-accidents-in-patients-with-ulcerative-colitis-in-a-single-academic-health-system
#6
JOURNAL ARTICLE
Erika Horta, Conor Burke-Smith, Bryant W Megna, Kendall J Nichols, Byron P Vaughn, Rwoof Reshi, Eugenia Shmidt
In general, IBD increases arteriovenous thromboembolic events, though the association between UC and cerebrovascular complications remains inconclusive. Some studies suggest young women with UC have an increased risk of cerebrovascular accidents (CVA). The focus of this study was to characterize the rates, anatomic distribution, and risk factors for CVA in patients with UC. We developed a retrospective cohort of patients with UC at a single health care system from June 2010 to June 2015. Neuroimaging was used to document presence, location and type of stroke and traditional risk factors were considered...
November 4, 2022: Scientific Reports
https://read.qxmd.com/read/35880319/pi4k2a-deficiency-causes-innate-error-in-intracellular-trafficking-with-developmental-and-epileptic-dyskinetic-encephalopathy
#7
JOURNAL ARTICLE
Hormos Salimi Dafsari, Joshua G Pemberton, Elizabeth A Ferrer, Tony Yammine, Chantal Farra, Mohammad Hasan Mohammadi, Ehsan Ghayoor Karimiani, Narges Hashemi, Mirna Souaid, Sandra Sabbagh, Paria Najarzadeh Torbati, Suliman Khan, Emmanuel Roze, Andres Moreno-De-Luca, Aida M Bertoli-Avella, Henry Houlden, Tamas Balla, Reza Maroofian
OBJECTIVE: Intracellular signaling networks rely on proper membrane organization to control an array of cellular processes such as metabolism, proliferation, apoptosis, and macroautophagy in eukaryotic cells and organisms. Phosphatidylinositol 4-phosphate (PI4P) emerged as an essential regulatory lipid within organelle membranes that defines their lipid composition and signaling properties. PI4P is generated by four distinct phosphatidylinositol 4-kinases (PI4K) in mammalian cells: PI4KA, PI4KB, PI4K2A, PI4K2B...
September 2022: Annals of Clinical and Translational Neurology
https://read.qxmd.com/read/35864917/seropositive-neuromyelitis-optica-in-a-case-of-undiagnosed-ankylosing-spondylitis-a-neuro-rheumatological-conundrum
#8
Ritwik Ghosh Md, Devlina Roy, Moisés León-Ruiz, Shambaditya Das, Souvik Dubey, Julián Benito-León
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy against foot processes of aquaporin-4 (AQP4) water channels. Patients with NMOSD tend to have other coexisting autoimmune/connective tissue diseases. However, AQP-4-antibody-positive NMOSD coexisting with ankylosing spondylitis (AS) is rare. AS is an immune-mediated disorder, a subset of axial spondyloarthropathies, which commonly manifests as chronic inflammatory back pain in young people, and it has a strong association with HLA-B27...
2022: Qatar Medical Journal
https://read.qxmd.com/read/35111602/altered-structural-covariance-and-functional-connectivity-of-the-insula-in-patients-with-crohn-s-disease
#9
JOURNAL ARTICLE
Shuming Zhang, Fenrong Chen, Jiayu Wu, Chengxiang Liu, Guang Yang, Ruiqing Piao, Bowen Geng, Ke Xu, Peng Liu
BACKGROUND: Crohn's disease (CD) is a clinically chronic inflammatory bowel disease, which has been shown to be closely related to the brain-gut axis dysfunction. Although traditionally considered to be a limbic region, the insula has also been commonly identified as an abnormal brain region in previous CD-related studies. METHODS: Structural magnetic resonance imaging (MRI) and resting-state functional MRI images were acquired from 45 CD patients in remission and 40 healthy controls (HCs)...
February 2022: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/34828768/acute-myelopathy-in-childhood
#10
REVIEW
Giulia Bravar, Aphra Luchesa Smith, Ata Siddiqui, Ming Lim
Acute myelopathy presenting in childhood can be clinically classified based on the location of injury (with resulting spinal syndrome) or the cause (broadly traumatic or non-traumatic). Types of nontraumatic myelopathy include ischaemic, infectious, inflammatory, nutritional, and metabolic causes, some of which may be part of a systemic illness such as systemic lupus erythematosus or a demyelinating disease such as multiple sclerosis. Nonaccidental injury is an important consideration in cases of traumatic myelopathy, which may often be associated with other injuries...
November 15, 2021: Children
https://read.qxmd.com/read/34734248/regional-gray-matter-volume-changes-in-brains-of-patients-with-ulcerative-colitis
#11
JOURNAL ARTICLE
Shuming Zhang, Fenrong Chen, Jiayu Wu, Chengxiang Liu, Guang Yang, Ruiqing Piao, Bowen Geng, Ke Xu, Peng Liu
BACKGROUND: Ulcerative colitis (UC) and Crohn's disease (CD) are 2 subtypes of inflammatory bowel disease (IBD). Several studies have reported brain abnormalities in IBD patients. This study aims to identify differences of gray matter volume (GMV) between patients with UC and healthy controls (HCs). METHODS: Fifty-seven patients with UC and 40 HCs underwent structural magnetic resonance imaging. Voxel-based morphometry method was used to detect GMV differences. Receiver operating characteristic (ROC) curve was applied to investigate reliable biomarkers for identifying patients with UC from HCs...
March 30, 2022: Inflammatory Bowel Diseases
https://read.qxmd.com/read/34347576/emerging-roles-of-il-34-in-neurodegenerative-and-neurological-infectious-disease
#12
JOURNAL ARTICLE
Gaurav Chhetri
Neurological infections are often devastating in their clinical presentation. Although significant advances have made in neuroimaging techniques and molecular tools for diagnosis, as well as in anti-infective therapy, these diseases always difficult to diagnose and treat. Neuroparasitic infections and virus infections lead to neurological infections. In the nervous system, various cytokines and chemokines act as neuroinflammatory agents, neuromodulators, regulate neurodevelopment, and synaptic transmission...
August 18, 2021: International Journal of Neuroscience
https://read.qxmd.com/read/33823388/altered-brain-structural-connectivity-in-patients-with-longstanding-gut-inflammation-is-correlated-with-psychological-symptoms-and-disease-duration
#13
JOURNAL ARTICLE
Joanna Turkiewicz, Ravi R Bhatt, Hao Wang, Priten Vora, Beatrix Krause, Jenny S Sauk, Jonathan P Jacobs, Charles N Bernstein, Jennifer Kornelsen, Jennifer S Labus, Arpana Gupta, Emeran A Mayer
OBJECTIVE: We aimed to identify differences in network properties of white matter microstructure between asymptomatic ulcerative colitis (UC) participants who had a history of chronic gut inflammation, healthy controls (HCs) and a disease control group without gut inflammation (irritable bowel syndrome; IBS). DESIGN: Diffusion weighted imaging was conducted in age and sex-matched participants with UC, IBS, and HCs (N = 74 each), together with measures of gastrointestinal and psychological symptom severity...
March 9, 2021: NeuroImage: Clinical
https://read.qxmd.com/read/33368950/exploring-joint-patterns-of-brain-structure-and-function-in-inflammatory-bowel-diseases-using-multimodal-data-fusion
#14
JOURNAL ARTICLE
Anne Kerstin Thomann, Mike Michael Schmitgen, Dagny Kmuche, Matthias Philip Ebert, Philipp Arthur Thomann, Kristina Szabo, Achim Gass, Martin Griebe, Wolfgang Reindl, Robert Christian Wolf
BACKGROUND: A growing number of neuroimaging studies suggest distinct neural changes in inflammatory bowel diseases (IBDs). Whether such changes may show similar spatial patterns across distinct neural features within and between specific IBD is unclear. To address this question, we used multivariate multimodal data fusion analysis to investigate structure/function modulation in remitted patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Patients with IBD (n = 46; n = 31 with CD, n = 15 with UC) in stable remission and 17 healthy controls (HC) underwent structural magnetic resonance imaging (sMRI) and resting-state functional magnetic resonance imaging (rs-fMRI) as well as cognitive testing...
December 28, 2020: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://read.qxmd.com/read/31628591/altered-functional-connectivity-of-the-amygdala-in-crohn-s-disease
#15
JOURNAL ARTICLE
Yingying Fan, Chunhui Bao, Ying Wei, Jiayu Wu, Yingsong Zhao, Xiao Zeng, Wei Qin, Huangan Wu, Peng Liu
Crohn's disease (CD), a chronic inflammatory bowel disease, involved in brain structural and functional changes, including the amygdala. Amygdala is a key structure in the limbic system and its related circuits are implicated in processing of emotion, pain and sensory. However, limited study of the amygdala is elucidated in CD. This study mainly investigated altered functional connectivity (FC) of the amygdala in CD patients during resting-state. Magnetic resonance imaging scans were acquired from 42 CD patients and 35 healthy controls (HCs)...
December 2020: Brain Imaging and Behavior
https://read.qxmd.com/read/31005923/protocol-for-a-pilot-randomised-controlled-trial-of-mindfulness-based-cognitive-therapy-in-youth-with-inflammatory-bowel-disease-and-depression
#16
JOURNAL ARTICLE
Tatjana Ewais, Jake Begun, Maura Kenny, Kai-Hsiang Chuang, Johanna Barclay, Karen Hay, Steve Kisely
INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic autoinflammatory disease of the gastrointestinal tract with peak age of onset during adolescence and young adulthood. Adolescents and young adults (AYAs) with IBD experience higher depression rates compared with peers who are well or have other chronic conditions. Mindfulness-based interventions are of particular interest because of their potential to improve both the course of IBD and depression. METHODS AND ANALYSIS: This study is a parallel design, single-blind, pilot randomised controlled trial (RCT) of mindfulness-based cognitive therapy (MBCT) in AYAs with IBD and depression...
April 20, 2019: BMJ Open
https://read.qxmd.com/read/24416245/regional-neuroplastic-brain-changes-in-patients-with-chronic-inflammatory-and-non-inflammatory-visceral-pain
#17
JOURNAL ARTICLE
Jui-Yang Hong, Jennifer S Labus, Zhiguo Jiang, Cody Ashe-Mcnalley, Ivo Dinov, Arpana Gupta, Yonggang Shi, Jean Stains, Nuwanthi Heendeniya, Suzanne R Smith, Kirsten Tillisch, Emeran A Mayer
Regional cortical thickness alterations have been reported in many chronic inflammatory and painful conditions, including inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS), even though the mechanisms underlying such neuroplastic changes remain poorly understood. In order to better understand the mechanisms contributing to grey matter changes, the current study sought to identify the differences in regional alterations in cortical thickness between healthy controls and two chronic visceral pain syndromes, with and without chronic gut inflammation...
2014: PloS One
https://read.qxmd.com/read/22078296/cerebral-thrombosis-complicating-crohn-s-disease-two-cases
#18
JOURNAL ARTICLE
Laïla Benjilali, Saadia Aidi, Hanane El Mansouri, Maria Benabdejlil, Mohamed Jiddane, Mostafa El Alaoui Faris
Cerebrovenous thrombosis is quite rare in infammatory bowel disease. There are only a few reports of this association in the literature. We report 2 cases of patients with Crohn's disease (CD) who developed cerebral thrombophlebitis confirmed by neuroimaging. The first case was a 35-year-old man with a history of CD who presented with acute confusion. Brain magnetic resonance imaging demonstrated a left temporoparietal infarction and thrombosis of the left lateral sinus. Coagulation studies showed a marked protein S deficiency...
November 2011: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/19824070/cerebral-thromboembolic-events-in-pediatric-patients-with-inflammatory-bowel-disease
#19
JOURNAL ARTICLE
A R Barclay, J M Keightley, I Horrocks, V Garrick, P McGrogan, R K Russell
BACKGROUND: There is a recognized association between pediatric inflammatory bowel disease (IBD) and cerebral thromboembolic events (CTEs). Historical reporting had described the association as strongest between ulcerative colitis (UC), rather than Crohn's disease (CD). We describe the incidence and outcome of CTE in pediatric IBD patients from a single center over 5 years and the relative proportion of stroke reported in the literature in patients with UC and CD before and after January 2000...
April 2010: Inflammatory Bowel Diseases
https://read.qxmd.com/read/14604067/evaluation-of-growth-disorders-in-the-paediatric-clinic
#20
REVIEW
M Cappa, S Loche
Growth is one of the most important indicators of child's well-being. The growth pattern is the result of the complex interaction between genetic and environment factors. The gold standard for the diagnosis of GH-deficient (GHD) children is not yet defined. In this review we focused on sensitivity and specificity of the commonly used test for GH secretion and neuroimaging evaluation. Initially, accurate determinations of height, weight, head circumferences and growth velocity should be performed and plotted on an appropriate growth chart...
2003: Journal of Endocrinological Investigation
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