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Neurogenic detrusor overactivity

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https://www.readbyqxmd.com/read/27846033/brush-cells-the-newly-identified-gatekeepers-of-the-urinary-tract
#1
Wolfgang Kummer, Klaus Deckmann
PURPOSE OF REVIEW: A specialized epithelial cell with chemosensory properties of taste cells known from the mouth has been newly identified in the urethra and linked to pathogen recognition. We here describe its properties and its link to defence mechanisms, showing parallels to similar sentinel cells in the respiratory and gastrointestinal tract. RECENT FINDINGS: In the urethra, slender epithelial cells with apical microvilli ('brush cells') express bitter and umami taste receptors and the downstream signalling cascade known from oropharyngeal gustation, utilizing it to monitor for bacterial products and bacterial growth facilitating conditions...
November 14, 2016: Current Opinion in Urology
https://www.readbyqxmd.com/read/27819757/urethral-pressure-variation-a-neglected-contributing-factor-in-patients-with-overactive-bladder-syndrome
#2
Kirschner-Hermanns Ruth, Anding Ralf, Gadzhiev Nariman, Campbell Adele, Goping Ing, Huppertz Nadine
OBJECTIVE: To study urethral pressure variations during the whole filling phase among different groups of patients. MATERIAL AND METHODS: We investigated 79 consecutive patients from January 2011 to June 2012. All patients were recruited within our routine practice in our continence clinic and were evaluated with urodynamic exam according to the standards of the International Continence Society (ICS) with an additional continuous measurement of the urethral pressure profile (cUPP) that was done in a supine position...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27816462/-lower-urinary-tract-dysfunction-in-normal-pressure-hydrocephalus-review-of-the-literature
#3
E Bey, B Nicot, O Casez, L Le Normand
INTRODUCTION: Lower urinary tract dysfunction in normal pressure hydrocephalus has received little attention from the scientific community. The aim of this review article was to discuss diagnostic and therapeutic options for these patients. SOURCES: A literature review of MedLine publications on urinary incontinence in normal pressure hydrocephalus was conducted. The following keywords were used: "hydrocephalus, normal pressure" and "bladder dysfunction" or "urinary incontinence" or "overactive bladder" or "urinary bladder, neurogenic"...
December 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27813141/renal-deterioration-after-spinal-cord-injury-is-associated-with-length-of-detrusor-contractions-during-cystometry-a-study-with-a-median-of-41-years-follow-up
#4
Marlene Elmelund, Niels Klarskov, Per Bagi, Peter S Oturai, Fin Biering-Sørensen
AIMS: To investigate which urodynamic parameters are associated with renal deterioration over a median of 41 years follow-up after traumatic spinal cord injury. METHODS: Medical records of patients with a traumatic spinal cord injury sustained 1944-1975 were reviewed from time of injury until 2012. Patients who attended regular renography and/or renal clearance examinations and had minimum one cystometry and pressure-flow study were included. Renal deterioration was diagnosed as split renal function ≤30% in one kidney or relative glomerular filtration rate ≤51% of expected according to age and gender...
November 4, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27765580/comparison-of-different-antibiotic-protocols-for-asymptomatic-bacteriuria-in-patients-with-neurogenic-bladder-treated-with-botulinum-toxin-a
#5
Ana Claudia Paradella, André Ferraz de Arruda Musegante, Carlos Brites
Intravesical botulinum toxin A (BoNTA) injection has been widely used for the treatment of detrusor overactivity in patients with neurogenic bladder due to spinal cord injury who do not respond to conventional treatment. There is no consensus about antibiotic prophylaxis for this procedure. We conducted a retrospective analysis of medical records of adult patients with spinal cord injury who underwent detrusor BoNTA injection between January of 2007 and December of 2013 in a rehabilitation hospital. Occurrence of symptomatic urinary tract infection (UTI) was assessed in 3 groups in accordance with their use of antibiotics (prophylactic dosage, 3 days, more than 3 days) for the treatment of asymptomatic bacteriuria...
October 18, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27676764/botulinum-toxin-therapy-for-neurogenic-detrusor-hyperactivity-versus-augmentation-enterocystoplasty-impact-on-the-quality-of-life-of-patients-with-sci
#6
Charles Fattal, Claire Anquetil, Samer Abdelhamid
OBJECTIVE: To compare quality of life (QoL) in patients with spinal cord injury who underwent overactive detrusor treatment by Botulinum Toxin (BT) versus augmentation cystoplasty (AC). MATERIALS/PATIENTS AND METHODS: Prospective and descriptive study. Patients with refractory overactive bladder due to SCI were treated by at least 2 successive injections of BT or by AC. QoL was assessed using Qualiveen-30 (Q30). Clinical data and urodynamic parameters were collected and compared...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676714/long-term-real-life-efficacy-of-onabotulinum-toxin-a-for-the-treatment-of-neurogenic-detrusor-overactivity-in-a-population-using-intermittent-self-catheterization
#7
Charles Joussain, Mélanie Popoff, Véronique Phé, Alexia Even, Laetitia Falcou, Emmanuel Chartier-Kastler, Brigitte Schurch, Pierre Denys
OBJECTIVE: Intradetrusor injection of onabotulinum toxin A (IDIBA) is the third-line therapy for patients with neurogenic detrusor overactivity (NDO). There is few evidence of long-term efficacy but no study assessed reasons for failure or abandonment of IDIBA and CISC (clean intermittent self-catheterization) combined strategy. We aimed to assess its long-term outcome in NDO management, and analyze failure and discontinuation. MATERIALS/PATIENTS AND METHODS: We retrospectively reviewed medical records of patients admitted in our neurourology department between 2001 and 2013...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676711/neurogenic-detrusor-overactivity-in-patients-with-hereditary-spastic-paraplegias
#8
Charles Joussain, Jonathan Levy, Audrey Charlanes, Alexia Even, Laetitia Falcou, Emmanuel Chartier-Kastler, Pierre Denys
OBJECTIVE: Hereditary spastic paraplegia (HSP) represents a clinically and genetically heterogeneous group of neurodegenerative diseases, with a worldwide estimated prevalence of 1.3/100,000 [1]. The "pure" form of HSP is a characterized by a progressive spastic paraplegia, often associated with lower urinary tract symptoms (LUTS) (72.4% to 77.6%) [2,3]. However, urologic complications are rarely reported. The aim of this study was to characterize clinical and urodynamic aspects of LUTS following HSP, and to describe treatment and urological complications of LUTS in a large series of HSP patients...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27664581/functional-magnetic-resonance-imaging-with-concurrent-urodynamic-testing-identifies-brain-structures-involved-in-micturition-cycle-in-patients-with-multiple-sclerosis
#9
Rose Khavari, Christof Karmonik, Michael Shy, Sophie Fletcher, Timothy Boone
PURPOSE: Neurogenic Lower Urinary Tract Dysfunction (NLUTD) is common in multiple sclerosis (MS) patients with a significant impact on their quality of life. In this study, we seek to discover brain activity processes during the micturition cycle in female patients with MS and NLUTD. MATERIALS AND METHODS: We report brain activity via functional magnetic resonance imaging (fMRI) and simultaneous urodynamic testing (UDS) in twenty-three ambulatory female patients with MS...
September 21, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27616488/antibiotic-prophylaxis-may-not-be-necessary-in-patients-with-asymptomatic-bacteriuria-undergoing-intradetrusor-onabotulinumtoxina-injections-for-neurogenic-detrusor-overactivity
#10
Lorenz Leitner, Ulla Sammer, Matthias Walter, Stephanie C Knüpfer, Marc P Schneider, Burkhardt Seifert, Jure Tornic, Ulrich Mehnert, Thomas M Kessler
Many of the patients undergoing intradetrusor onabotulinumtoxinA injections for refractory neurogenic detrusor overactivity (NDO) present with chronic bacteriuria. In these patients, antibiotic prophylaxis has been widely recommended since bacteriuria might impair treatment efficacy and cause urinary tract infections (UTI) but the evidence is limited. The aim of this study was to evaluate if an antibiotic prophylaxis is needed in patients with asymptomatic bacteriuria undergoing intradetrusor onabotulinumtoxinA injections...
September 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27596481/preserved-micturition-after-intradetrusor-onabotulinumtoxina-injection-for-treatment-of-neurogenic-bladder-dysfunction-in-parkinson-s-disease
#11
Stephanie C Knüpfer, Susanne A Schneider, Mareike M Averhoff, Carsten M Naumann, Günther Deuschl, Klaus-Peter Jünemann, Moritz F Hamann
BACKGROUND: To assess the efficacy and safety of intradetrusor onabotulinumtoxinA (OnabotA) injection treatment in patients with neurogenic lower urinary tract dysfunction (NLUTD), especially for patients with Parkinson disease (PD). METHODS: PD patients refractory to oral antimuscarinic participated in an off-label use study and were evaluated prior and after 200 IU OnabotA injection into detrusor muscle, including trigone. Changes due to treatment were evaluated using bladder diaries, urodynamics, and questionnaires...
2016: BMC Urology
https://www.readbyqxmd.com/read/27527382/pathophysiology-clinical-importance-and-management-of-neurogenic-lower-urinary-tract-dysfunction-caused-by-suprasacral-spinal-cord-injury
#12
H Z Hu, N Granger, N D Jeffery
Management of persistent lower urinary tract dysfunction resulting from severe thoracolumbar spinal cord injury can be challenging. Severe suprasacral spinal cord injury releases the spinal cord segmental micturition reflex from supraspinal modulation and increases nerve growth factor concentration in the bladder wall, lumbosacral spinal cord, and dorsal root ganglion, which subsequently activates hypermechanosensitive C-fiber bladder wall afferents. Hyperexcitability of bladder afferents and detrusor overactivity can cause urine leaking during the storage phase...
September 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27494539/mucosal-modulation-of-contractility-in-bladder-strips-from-normal-and-overactive-rat-models-and-the-effect-of-botulinum-toxin-a-on-overactive-bladder-strips
#13
Patrick C Campbell, Bronagh McDonnell, Kevin P Monaghan, Lauren Baysting, Oonagh Little, Karen D McCloskey
AIMS: To investigate the local, regulatory role of the mucosa on bladder strip contractility from normal and overactive bladders and to examine the effect of botulinum toxin A (BoNT-A). METHODS: Bladder strips from spontaneously hyperactive rat (SHR) or normal rats (Sprague Dawley, SD) were dissected for myography as intact or mucosa-free preparations. Spontaneous, neurogenic and agonist-evoked contractions were investigated. SHR strips were incubated in BoNT-A (3 h) to assess effects on contractility...
August 5, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27463810/efficacy-and-safety-of-onabotulinumtoxina-in-patients-with-neurogenic-detrusor-overactivity-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#14
Tao Cheng, Wei-Bing Shuang, Dong-Dong Jia, Min Zhang, Xu-Nan Tong, Wei-Dong Yang, Xu-Ming Jia, Shuo Li
BACKGROUND: Neurogenic detrusor overactivity (NDO) affects the quality of life (QoL) of millions of individuals worldwide. The purpose of this study was to assess the efficacy and safety of onabotulinumtoxinA in patients with NDO using a network meta-analytic approach, which can also quantify and compare the efficacy of onabotulinumtoxinA across different dosages. METHODS: PubMed, EMBASE, and the Controlled Trials Register were searched to identify randomized controlled trials comparing onabotulinumtoxinA to a control for NDO in adult patients...
2016: PloS One
https://www.readbyqxmd.com/read/27454267/two-year-outcome-of-percutaneous-bipolar-radiofrequency-neurotomy-of-sacral-nerves-s2-and-s3-in-spinal-cord-injured-patients-with-neurogenic-detrusor-overactivity-a-randomized-controlled-feasibility-study
#15
Hae Min Jo, Hyo Sung Kim, Yun-Woo Cho, Sang-Ho Ahn
BACKGROUND: Little research has been expended on the use of bipolar radiofrequency (RF) lesioning of sacral nerves in spinal cord injured (SCI) patients with neurogenic detrusor overactivity (NDO), and no study has been undertaken to demonstrate its long-term effect. OBJECTIVE: To investigated the effect of bipolar RF ablation of the second and third sacral nerves over 2 years in SCI patients with NDO. STUDY DESIGN: A prospective, randomized controlled feasibility study...
July 2016: Pain Physician
https://www.readbyqxmd.com/read/27401178/neurogenic-lower-urinary-tract-dysfunction-evaluation-and-management
#16
Katarina Ivana Tudor, Ryuji Sakakibara, Jalesh N Panicker
The lower urinary tract (LUT) in health is regulated by coordinated multi-level neurological inputs which require an intact central and peripheral nervous system. Lower urinary tract dysfunction is, therefore, a common sequelae of neurological disease and the patterns of bladder storage and voiding dysfunction depend upon the level of neurological lesion. Evaluation includes history taking, bladder diary, urological examination when relevant, ultrasonography and urodynamic testing when indicated. Antimuscarinic agents are the first line treatment for patients with storage dysfunction...
December 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27342082/effects-of-onabotulinumtoxina-on-cardiac-function-following-intradetrusor-injections
#17
Ulrich Mehnert, Laetitia M de Kort, Jens Wöllner, Marko Kozomara, Gommert A van Koeveringe, Thomas M Kessler
: OnabotulinumtoxinA intradetrusor injections are considered a highly effective localized therapy for refractory detrusor overactivity. However, despite evidence for distant systemic effects of onabotulinumtoxinA, little is known on potential systemic side effects following intradetrusor injections. Given that onabotulinumtoxinA is a highly potent toxin this is an important safety issue specifically with regard to repeat injections and parallel treatments with botulinum toxin. Hence, it was the purpose of this prospective study to investigate, using heart rate variability (HRV) analysis, whether onabotulinumtoxinA causes systemic effects on cardiac function following intradetrusor injections...
June 21, 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27314246/urodynamic-findings-in-patients-with-creutzfeldt-jakob-disease-a-case-report
#18
Masashi Yano, Ryuji Sakakibara, Fuyuki Tateno, Osamu Takahashi, Haruka Nakamura, Megumi Sugiyama, Lee Fang-Ching, Syuichi Kamijima, Naoto Kamiya, Hiroyoshi Suzuki
AIM OF STUDY: Urinary dysfunction in Creutzfeldt-Jakob disease (CJD) patients is attributed to functional incontinence, since they often have immobility and loss of motivation. In contrast, previously no urodynamic findings are available in CJD patients. CASE REPORT: We had 2 CJD patients who had urinary frequency and urinary retention. We performed urodynamics with the spouse's informed consent in order to explore the mechanism of urinary dysfunction in those cases...
October 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27283922/less-is-more-a-pilot-study-evaluating-one-to-three-intradetrusor-sites-for-injection-of-onabotulinumtoxina-for-neurogenic-and-idiopathic-detrusor-overactivity
#19
Michael A Avallone, Bryan S Sack, Ahmad El-Arabi, Michael L Guralnick, R Corey O'Connor
AIMS: To determine if minimizing the number of onabotulinumtoxinA (BTX) injection sites to one to three locations provides similar clinical efficacy and duration of effect compared to the established technique in treating patients with neurogenic (NDO) or idiopathic detrusor overactivity (IDO). METHODS: Prospective data were collected on BTX naïve patients with NDO or IDO who were intolerant or refractory to oral medications. Patients were treated with 100-300 U of BTX via one to three injection sites...
June 10, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27272312/long-term-follow-up-of-intravesical-botulinum-toxin-a-injections-in-women-with-idiopathic-overactive-bladder-symptoms
#20
T A T Marcelissen, M S Rahnama'i, A Snijkers, B Schurch, P De Vries
INTRODUCTION: Intravesical botulinum toxin (BoNT-A) is a safe and effective treatment for overactive bladder syndrome. There are many reports on the clinical experience with BoNT-A, especially in patients with neurogenic detrusor overactivity. The US Food and Drug Administration has recently approved its use for idiopathic overactive bladder (iOAB). Various studies have reported positive results for iOAB in the short-term. Yet little is known about the results after repeated BoNT-A injections...
June 7, 2016: World Journal of Urology
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