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Neurogenic detrusor overactivity

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https://www.readbyqxmd.com/read/28991688/postvoid-residual-predicts-the-diagnosis-of-multiple-system-atrophy-in-parkinsonian-syndrome
#1
Tatsuya Yamamoto, Masato Asahina, Yoshitaka Yamanaka, Tomoyuki Uchiyama, Shigeki Hirano, Miki Fuse, Yasuko Koga, Ryuji Sakakibara, Satoshi Kuwabara
OBJECTIVE: It is difficult to differentiate multiple system atrophy (MSA) from Parkinson's disease (PD) at least in the early stage. Urodynamic study (UDS) is useful in differentiating MSA from PD. We aimed to clarify which UDS parameter was useful in differentiating MSA from PD. METHODS: We retrospectively reviewed 273 cases and performed UDS and external anal sphincter electromyography (EAS-EMG) in patients with MSA (n=182) and PD (n=91). We analyzed the utility of UDS parameters, including postvoid residuals (PVR), detrusor overactivity (DO), degree of bladder contraction, and mean duration of motor unit potentials (MUPs) in EAS-EMG, for differentiating MSA from PD...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28969876/review-of-underactive-bladder
#2
REVIEW
Yi-Huei Chang, Justin Ji-Yuen Siu, Po-Jen Hsiao, Chao-Hsiang Chang, Eric Chieh-Lung Chou
In clinical practice, many patients cannot empty their bladders within an acceptable duration. Common complaints include weak urinary stream and incomplete emptying, which may affect quality of life. Bladder emptying requires sufficient detrusor contractile power, velocity, and durability. The urodynamic term for inadequate detrusor contraction is detrusor underactivity (DU). Although this definition was provided by the ICS, it may not be clinically practical. Analogous to the relationship between overactive bladder (OAB) and detrusor overactivity (DO), the symptom complex caused by DU is termed underactive bladder (UAB)...
September 29, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28943369/clinical-and-urodynamic-results-of-repeated-intradetrusor-onabotulinum-toxin-a-injections-in-refractory-neurogenic-detrusor-overactivity-up-to-five-injections-in-a-cohort-of-children-with-myelodysplasia
#3
Cagri Akin Sekerci, Yiloren Tanidir, Asgar Garayev, Cem Akbal, Tufan Tarcan, Ferruh Simsek
OBJECTIVE: To determine the efficacy and safety of repeated intradetrusor onabotulinum toxin A (onaBoNT-A) injections in children with neurogenic detrusor overactivity due to myelodysplasia. METHODS: The study group consisted of 19 children (4 boys, 15 girls), with a mean age of 10.3±3.1 years old, who had received at least two injections of 10 U/kg onaBoNT-A for the treatment of urinary incontinence resistant to anticholinergic treatment and clean intermittent catheterization in our clinic, between 2010 and 2015...
September 21, 2017: Urology
https://www.readbyqxmd.com/read/28942324/morphological-changes-in-different-populations-of-bladder-afferent-neurons-detected-by-herpes-simplex-virus-hsv-vectors-with-cell-type-specific-promoters-in-mice-with-spinal-cord-injury
#4
Nobutaka Shimizu, Mark F Doyal, William F Goins, Katsumi Kadekawa, Naoki Wada, Anthony J Kanai, William C de Groat, Akihide Hirayama, Hirotsugu Uemura, Joseph C Glorioso, Naoki Yoshimura
Functional and morphological changes in C-fiber bladder afferent pathways are reportedly involved in neurogenic detrusor overactivity (NDO) after spinal cord injury (SCI). This study examined the morphological changes in different populations of bladder afferent neurons after SCI using replication-defective herpes simplex virus (HSV) vectors encoding the mCherry reporter driven by neuronal cell-type-specific promoters. Spinal intact (SI) and SCI mice were injected into the bladder wall with HSV mCherry vectors driven by the cytomegalovirus (CMV) promoter, CGRP promoter, TRPV1 promoter or neurofilament 200 (NF200) promoter...
September 20, 2017: Neuroscience
https://www.readbyqxmd.com/read/28877353/adolescence-transitional-care-in-neurogenic-detrusor-overactivity-and-the-use-of-onabotulinumtoxina-a-clinical-algorithm-from-an-italian-consensus-statement
#5
REVIEW
Giovanni Palleschi, Giovanni Mosiello, Valerio Iacovelli, Stefania Musco, Giulio Del Popolo, Antonella Giannantoni, Antonio Carbone, Roberto Carone, Andrea Tubaro, Mario De Gennaro, Antonio Marte, Enrico Finazzi Agrò
AIMS: OnabotulinumtoxinA (onaBNTa) for treating neurogenic detrusor overactivity (NDO) is widely used after its regulatory approval in adults. Although the administration of onaBNTa is still considered off-label in children, data have already been reported on its efficacy and safety. Nowadays, there is a lack of standardized protocols for treatment of NDO with onaBNTa in adolescent patients in their transition from the childhood to the adult age. With the aim to address this issue a consensus panel was obtained...
September 6, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28865604/efficacy-of-holmium-laser-enucleation-of-the-prostate-holep-in-men-with-bladder-outlet-obstruction-boo-and-non-neurogenic-bladder-dysfunction
#6
Jong Hyun Pyun, Sung Gu Kang, Seok Ho Kang, Jun Cheon, Je Jong Kim, Jeong Gu Lee
We aimed to compare the short-term outcomes of men who had urodynamic evidence of detrusor underactivity (DU) or detrusor overactivity (DO) of a non-neurogenic etiology as well as bladder outlet obstruction (BOO) and who underwent Holmium Laser Enucleation of the prostate (HoLEP). A database of 322 patients who underwent HoLEP between 2010 and 2014 was analyzed. Patients were classified into three groups according to the results of a preoperative urodynamic study. Preoperative parameters such as International Prostate Symptom Score (IPSS), Quality of Life (QoL) index, IPSS grade, uroflowmetry were compared with postoperative parameters measured at 6 months...
September 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28819801/botulinum-toxin-treatment-in-multiple-sclerosis-a-review
#7
REVIEW
Yasaman Safarpour, Tahereh Mousavi, Bahman Jabbari
Purpose of review The purpose of this review is to provide updated information on the role of botulinum neurotoxin (BoNT) therapy in multiple sclerosis (MS). This review aims to answer which symptoms of multiple sclerosis may be amenable to BoNT therapy. Recent findings We searched the literature on the efficacy of BoNTs for treatment of MS symptoms up to April 1st 2017 via the Yale University Library's search engine including but not limited to Pub Med and Ovis SP. The level of efficacy was defined according to the assessment's criteria set forth by the Subcommittee on Guideline Development of the American Academy of Neurology...
August 17, 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28815978/an-important-counseling-tool-for-urologists-managing-patients-with-neurogenic-detrusor-overactivity
#8
EDITORIAL
Elodi Dielubanza, Sandip Vasavada
No abstract text is available yet for this article.
September 2017: BJU International
https://www.readbyqxmd.com/read/28782880/adaptive-changes-of-telocytes-in-the-urinary-bladder-of-patients-affected-by-neurogenic-detrusor-overactivity
#9
Chiara Traini, Maria-Simonetta Fausssone-Pellegrini, Daniele Guasti, Giulio Del Popolo, Jacopo Frizzi, Sergio Serni, Maria-Giuliana Vannucchi
Urinary bladder activity involves central and autonomic nervous systems and bladder wall. Studies on the pathogenesis of voiding disorders such as the neurogenic detrusor overactivity (NDO) due to suprasacral spinal cord lesions have emphasized the importance of an abnormal handling of the afferent signals from urothelium and lamina propria (LP). In the LP (and detrusor), three types of telocytes (TC) are present and form a 3D-network. TC are stromal cells able to form the scaffold that contains and organizes the connective components, to serve as guide for tissue (re)-modelling, to produce trophic and/or regulatory molecules, to share privileged contacts with the immune cells...
August 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28771936/intradetrusor-onabotulinumtoxina-injections-for-refractory-neurogenic-detrusor-overactivity-incontinence-do-we-need-urodynamic-investigation-for-outcome-assessment
#10
Miriam Koschorke, Lorenz Leitner, Helen Sadri, Stephanie C Knüpfer, Ulrich Mehnert, Thomas M Kessler
OBJECTIVE: To evaluate if urinary continence after intradetrusor onabotulinumtoxinA injections is sufficient for appropriate outcome assessment or if urodynamic investigation (UDI) is needed. PATIENTS AND METHODS: A consecutive series of 148 patients undergoing intradetrusor onabotulinumtoxinA injections for refractory neurogenic detrusor overactivity (NDO) incontinence were prospectively evaluated. Patients underwent UDI prior and 6 weeks after onabotulinumtoxinA injections...
August 3, 2017: BJU International
https://www.readbyqxmd.com/read/28751267/detrusor-contraction-during-rapid-bladder-filling-caused-by-cold-or-warm-water-a-randomized-controlled-double-blind-trial
#11
Marko Kozomara, Ulrich Mehnert, Burkhardt Seifert, Thomas M Kessler
PURPOSE: We investigated if the detrusor contraction during rapid bladder filling is provoked by cold or warm water. PATIENTS & METHODS: Patients suffering from neurogenic lower urinary tract dysfunction (NLUTD) were included into this randomized controlled double-blind trial. At the end of standard urodynamic investigation, the patients received 2 fillings of the bladder using a 4°C (ice water test, IWT) or 36°C (warm water test, WWT) saline solution with a speed of 100 mL/min...
July 24, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28745818/is-repeat-botulinum-toxin-a-injection-valuable-for-neurogenic-detrusor-overactivity-a-systematic-review-and-meta-analysis
#12
REVIEW
Jianshu Ni, Xiaohu Wang, Nailong Cao, Jiemin Si, Baojun Gu
AIM: To investigate the value of repeat botulinum toxin A (BTX-A) injections in patients with neurogenic detrusor overactivity (NDO). METHODS: We searched the PubMed, EMBASE, and EBSCO databases for articles published until June 2016. Studies that reported the efficacy and safety of repeat BTX-A injections for adult patients with NDO were eligible. The effect size for each outcome was calculated as the standardized mean difference ± standard error and 95% confidence interval, and was graded as small, >0...
July 26, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28745807/long-term-outcomes-and-risks-factors-for-failure-of-intradetrusor-onabotulinumtoxin-a-injections-for-the-treatment-of-refractory-neurogenic-detrusor-overactivity
#13
Charles Joussain, Mélanie Popoff, Véronique Phé, Alexia Even, Pierre-Olivier Bosset, Sandra Pottier, Laetitia Falcou, Jonathan Levy, Isabelle Vaugier, Emmanuel Chartier Kastler, Brigitte Schurch, Pierre Denys
AIMS: Aims of this study were to assess the long-term outcomes of Intradetrusor injection of OnabotulinumtoxinA (Botox® injection) associated with clean intermittent-catheterization (CIC) for the treatment of neurogenic detrusor overactivity (NDO) and to identify risk factors for failure. METHODS: Neurological patients with NDO using CIC who had received Botox® injections between January 2001 and September 2013 were included. Clinical, urodynamic and radiological data were recorded...
July 26, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28723381/efficacy-and-safety-of-onabotulinumtoxina-in-patients-with-urinary-incontinence-due-to-neurogenic-detrusor-overactivity-update-of-the-pivotal-randomised-double-blind-placebo-controlled-trials
#14
Carlos Martins-Silva, Francisco Cruz
Bladder injections of 200U onabotulinumtoxinA have similar efficacy in the treatment of urinary incontinence in patients with multiple sclerosis or spinal cord injury. The effect is maintained in the long term without significant adverse events.
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28716326/disease-specific-outcomes-of-botulinum-toxin-injections-for-neurogenic-detrusor-overactivity
#15
REVIEW
Aaron Kaviani, Rose Khavari
Intradetrusor injection of botulinum toxin A (BTX-A) is an effective option for managing patients with neurogenic detrusor overactivity (NDO) who do not respond to or tolerate oral pharmacologic agents. There is level I evidence that intradetrusor injection of onabotulinumtoxinA for refractory NDO in patients with multiple sclerosis and spinal cord injury is associated with a significantly greater achievement of goals and improved performance in urodynamic studies than placebo. Pilot studies or small case series support BTX-A for NDO in patients with Parkinson's disease and cerebrovascular accident...
August 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28716323/chronic-urinary-retention-in-multiple-sclerosis-patients-physiology-systematic-review-of-urodynamic-data-and-recommendations-for-care
#16
REVIEW
John T Stoffel
Many multiple sclerosis (MS) patients are affected by urinary retention. Common causes include neurogenic underactive bladder and/or bladder outlet obstruction from detrusor sphincter dyssynergia. Systemic review of contemporary MS urodynamic studies demonstrates that 53% of MS patients have detrusor overactivity, 43% have detrusor sphincter dyssynergia, and 12% have atonic bladder (12 studies, 1524 patients). There is no standard definition of MS-related urinary retention, but greater than 300 mL is a proposed threshold value for the condition based on literature review...
August 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28714784/the-management-of-paediatric-neurogenic-bladder-an-approach-in-a-resource-poor-setting
#17
Patrick Opoku Manu Maison, John Lazarus
BACKGROUND: If untreated, paediatric neurogenic bladder can cause renal failure and urinary incontinence. It is usually caused by neural tube defects such as myelomeningocele. Children with a neurogenic bladder should be monitored from birth and management should aim to preserve renal function and achieve social continence. This article outlines the management options appropriate for these children in resource-poor settings. ASSESSMENT: In most low- and middle-income countries, a general lack of awareness of the neurological effects on the urinary tract results in late presentation, usually with urological complications even when spina bifida is diagnosed early...
July 17, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28712052/pharmacotherapy-for-pediatric-neurogenic-bladder
#18
REVIEW
Paweł Kroll
Neurogenic bladder (NB) is a nonspecific term that may describe conditions ranging from areflectic noncontractile bladder to detrusor overactivity. The most common cause of NB in children is the presence of dysraphic malformations. Urodynamic evaluations make it possible to describe bladder dysfunctions and to plan a therapeutic strategy for each patient. In a child with NB there are two major dangerous functional problems seen in urodynamic investigations: high intravesical pressure in the storage phase and high pressure during urination...
July 15, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28699369/single-centre-experience-with-intradetrusor-injection-of-onabotulinumtoxina-a-retrospective-study-of-the-years-2003-2012-in-a-danish-population
#19
Frederikke Eichner Christiansen, Torben Brøchner Pedersen, Jacob Juel, Hans Jørgen Kirkeby
OBJECTIVE: This study aimed to evaluate the efficacy of treatment for incontinence due to neurogenic detrusor overactivity (NDO) and idiopathic detrusor overactivity (IDO) with onabotulinumtoxinA (BoNT-A) at Aarhus University Hospital, Skejby, Denmark. MATERIALS AND METHODS: The data were collected retrospectively by systematic review of the patient records from March 2003 to May 2012. Patients treated with BoNT-A over the age of 18 years were included. Treatment indication, diagnosis, adverse events, treatment interval, duration of effect and effect grade were registered...
July 12, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28666061/conditional-neuromodulation-of-neurogenic-detrusor-overactivity-using-transrectal-stimulation-in-patients-with-spinal-cord-injury-a-proof-of-principle-study
#20
Sarah Louise Knight, Nuwani Edirisinghe, Brian Leaker, Judith Susser, Michael Duncan Craggs
AIMS: A proof of principle study of a novel wearable device to control neurogenic detrusor over-activity in eight male spinal cord injured subjects using conditional neuromodulation. METHODS: Transrectal stimulation was delivered through the device in response to simultaneously recorded external anal sphincter (EAS) contraction as a marker for neurogenic detrusor overactivity (NDO). The effect of conditional neuromodulation on bladder capacity and maximum detrusor pressure was investigated in addition to reliability of dyssynergic sphincter contraction as a marker for NDO...
June 30, 2017: Neurourology and Urodynamics
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