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Urgency urinary incontinence

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https://www.readbyqxmd.com/read/29784450/physician-assessed-and-patient-reported-urinary-morbidity-after-radio-chemotherapy-and-image-guided-adaptive-brachytherapy-for-locally-advanced-cervical-cancer
#1
Lars Fokdal, Richard Pötter, Kathrin Kirchheiner, Jacob Chr Lindegaard, Nina Boje Kibsgaard Jensen, Christian Kirisits, Cyrus Chargari, Umesh Mahantshetty, Ina Maria Jürgenliemk-Schulz, Barbara Segedin, Peter Hoskin, Kari Tanderup
BACKGROUND AND PURPOSE: The EMBRACE study is a prospective multi-institutional study on MRI guided adaptive brachytherapy (IGABT) in locally advanced cervix cancer (LACC). This analysis describes early to late urinary morbidity assessed by physicians and patients (PRO). MATERIAL AND METHODS: A total of 1176 patients were analysed. Median follow up (FU) was 27 (1-83) months. Morbidity (CTCAE v.3) and PRO (EORTC QLQ-C30&CX24) was prospectively assessed at baseline (BL), and during FU...
May 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29781068/pelvic-floor-muscle-training-with-or-without-tibial-nerve-stimulation-and-lifestyle-changes-have-comparable-effects-on-the-overactive-bladder-a-randomized-clinical-trial
#2
Lina Bykoviene, Raimondas Kubilius, Rosita Aniuliene, Egle Bartuseviciene, Arnoldas Bartusevicius
PURPOSE: To compare effects of transcutaneous posterior tibial nerve stimulation (TPTNS) and pelvic floor muscle training (PFMT) in women with overactive bladder syndrome (OAB). MATERIAL AND METHODS: We randomized 67 women ? 18 years with OAB to three parallel groups: group I (n = 22) received life-style recommendations (LSR) only; group II (n = 24) had LSR + PFMT and group III (n = 21) had LSR + PFMT + TPTNS. Urgency, evaluated by a 3-day voiding diary before treatment and six weeks later, was the main outcome measure...
May 21, 2018: Urology Journal
https://www.readbyqxmd.com/read/29780784/risk-factors-and-factors-affecting-the-severity-of-overactive-bladder-symptoms-in-korean-women-who-use-public-health-centers
#3
Jungsoo Chae, Eun-Hee Yoo, Yeonseong Jeong, Seungyeon Pyeon, Donguk Kim
Objective: To investigate the prevalence, risk factors of overactive bladder (OAB) and the factors affecting the severity of OAB symptoms. Methods: A total 822 interviews with women aged 18-80 years who visited public health centers were conducted between April 2014 and April 2015. The questionnaire was composed of 16 questions about urinary symptoms, 14 questions about self-treatment and the use of complementary and alternative medicine, and 21 questions about socio-demographic characteristics...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29769252/frequency-of-non-motor-symptoms-in-parkinson-s-disease-presenting-to-tertiary-care-centre-in-pakistan-an-observational-cross-sectional-study
#4
Shahid Mukhtar, Rashid Imran, Mohsin Zaheer, Huma Tariq
OBJECTIVE: To determine the frequency of non-motor symptoms (NMS) in patients of Parkinson's disease (PD) presenting to a movement disorder clinic at a tertiary care centre in Pakistan, and how frequency of NMS is different in male and female patients. STUDY DESIGN: Observational, cross-sectional study. SETTING: Tertiary care centre. PARTICIPANTS: Out of 102 patients, 85 were included. Inclusion criteria were patients with PD diagnosed according to the UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria, age ≥18 years, able to give consent and have no difficulty in answering questions...
May 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29767449/outcomes-of-intradetrusor-onabotulinum-toxin-a-injection-in-patients-with-parkinson-s-disease
#5
Gregory Vurture, Benoit Peyronnet, Andrew Feigin, Milton C Biagioni, Rebecca Gilbert, Nirit Rosenblum, Steven Frucht, Alessandro Di Rocco, Victor W Nitti, Benjamin M Brucker
OBJECTIVE: To assess the safety and efficacy of intradetrusor onabotulinum toxin A injections for the treatment of overactive bladder (OAB) in patients with Parkinson's disease (PD). METHODS: All PD patients who underwent intradetrusor injections of onabotulinum toxin A (BoNT-A) for storage symptoms between 2010 and 2017 were included in a retrospective study. A 100 U dose of BoNT-A (Botox®, Allergan Irvine, CA) was used for the first injection in all patients...
May 16, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29747213/treatment-of-non-neurogenic-overactive-bladder-with-onabotulinumtoxina-systematic-review-and-meta-analysis-of-prospective-randomized-placebo-controlled-clinical-trials
#6
Raquel Martins Arruda, Claudia Cristina Takano, Manoel João Batista Castelo Girão, Jorge Milhem Haddad, Gabriel Francisco Aleixo, Rodrigo Aquino Castro
We performed a systematic review and meta-analysis of randomized placebo-controlled trials that studied non-neurogenic overactive bladder patients who were treated with 100 units of onabotulinumtoxinA or placebo. The primary purpose of our study was to evaluate the clinical effectiveness with regard to urinary urgency, urinary frequency, nocturia, and incontinence episodes. Our secondary purpose consisted of evaluating the adverse effects. Our initial search yielded 532 entries. Of these, seven studies met all the inclusion criteria (prospective, randomized, placebo-controlled studies, ≥ 3 points on the Jadad scale) and were selected for analysis...
April 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29746860/intradetrusor-injections-of-botulinum-toxin-a-in-adult-patients-with-spinal-dysraphism
#7
Benoit Peyronnet, Alexia Even, Grégoire Capon, Marianne de Seze, Juliette Hascoet, Xavier Biardeau, Maximilien Baron, Marie-Aimée Perrouin-Verbe, Jean-Michel Boutin, Christian Saussine, Véronique Phé, Loic Lenormand, Emmanuel Chartier-Kastler, Jean-Nicolas Cornu, Gilles Karsenty, Andrea Manunta, Brigitte Schurch, Pierre Denys, Gérard Amarenco, Xavier Game
PURPOSE: The aim of the present study was to report the outcomes of botulinum toxin A (BTX-A) intradetrusor injections in adult patients with spina bifida. MATERIALS AND METHODS: All patients with spinal dysraphism who had undergone intradetrusor injections of BTX-A from 2002 to 2016 in 14 centers were included retrospectively. The primary endpoint was the global success of injections, defined subjectively as the combination of urgency, urinary incontinence and detrusor overactivity/low bladder compliance resolution...
May 7, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29745041/cluster-analysis-of-multiple-chronic-conditions-associated-with-urinary-incontinence-among-women-in-the-usa
#8
Alayne D Markland, Camille P Vaughan, Ike S Okosun, Patricia S Goode, Kathryn L Burgio, Theodore M Johnson
OBJECTIVE: To identify patterns of prevalent chronic medical conditions among women with urinary incontinence (UI). MATERIALS AND METHODS: We combined cross-sectional data from the 2005-2006 to 2011-2012 US National Health and Nutrition Examination Surveys, and identified 3 800 women with UI and data on 12 chronic conditions. Types of UI included stress UI (SUI), urgency UI (UUI), and mixed stress and urgency UI (MUI). We categorized UI as mild, moderate or severe using validated measures...
May 9, 2018: BJU International
https://www.readbyqxmd.com/read/29730202/mental-health-sleep-and-physical-function-in-treatment-seeking-women-with-urinary-incontinence
#9
Nazema Y Siddiqui, Jonathan B Wiseman, David Cella, Catherine S Bradley, H Henry Lai, Margaret E Helmuth, Abigail R Smith, James W Griffith, Cindy L Amundsen, Kimberly S Kenton, J Quentin Clemens, Karl J Kreder, Robert M Merion, Ziya Kirkali, John W Kusek, Anne P Cameron
PURPOSE: To examine how mental health measures, sleep, and physical function are associated with presence and type of urinary incontinence (UI) and severity in women seeking treatment for lower urinary tract symptoms (LUTS). METHODS: This is a baseline cross-sectional analysis in treatment-seeking women with LUTS. All participants completed the LUTS Tool, which was used to classify women based on UI symptoms and measure severity. Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaires for depression, anxiety, sleep disturbance, and physical function; the Perceived Stress Scale (PSS); and the International Physical Activity Questionnaire Short Form (IPAQ-SF) were administered...
May 3, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29728163/impact-of-adenotonsillectomy-on-urinary-storage-symptoms-in-children-with-sleep-disordered-breathing
#10
Jong Cheol Lee, Kyung Hyun Moon, Taekmin Kwon, Seong Kyeong Yang, Sungchan Park
OBJECTIVE: To prospectively evaluate the effectiveness of adenotonsillectomy on resolving urinary storage symptoms such as frequency, urgency, and urgency urinary incontinence (UUI) in indicated sleep disordered breathing (SDB) patients. METHODS: We prospectively analyzed changes in storage symptoms and SDB score before and after surgery in 102 children (74 males, 28 females, mean age 8.4 ± 2.8 years) who underwent adenotonsillectomy between July 2011 and Feb 2012...
June 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29709423/basic-and-clinical-aspects-of-antimuscarinic-agents-used-to-treat-overactive-bladder
#11
REVIEW
Shizuo Yamada, Yoshihiko Ito, Saori Nishijima, Katsumi Kadekawa, Kimio Sugaya
Antimuscarinic agents are now widely used as the pharmacological therapy for overactive bladder (OAB) because neuronal (parasympathetic nerve) and non-neuronal acetylcholine play a significant role for the bladder function. In this review, we will highlight basic and clinical aspects of eight antimuscarinic agents (oxybutynin, propiverine, tolterodine, solifenacin, darifenacin, trospium, imidafenacin, and fesoterodine) clinically used to treat urinary dysfunction in patients with OAB. The basic pharmacological characteristics of these eight antimuscarinic agents include muscarinic receptor subtype selectivity, functional bladder selectivity, and muscarinic receptor binding in the bladder and other tissues...
April 27, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29699858/efficacy-and-tolerability-of-mirabegron-compared-with-antimuscarinic-monotherapy-or-combination-therapies-for-overactive-bladder-a-systematic-review-and-network-meta-analysis
#12
Con Kelleher, Zalmai Hakimi, Richard Zur, Emad Siddiqui, Khaled Maman, Samuel Aballéa, Jameel Nazir, Chris Chapple
BACKGROUND: Mirabegron is an established treatment alternative to antimuscarinic therapy for patients with overactive bladder (OAB), as shown by efficacy and tolerability data from phase III trials. OBJECTIVE: To assess efficacy and tolerability of mirabegron 50mg versus antimuscarinic monotherapies and combination therapies. DESIGN, SETTING, AND PARTICIPANTS: Systematic literature review and network meta-analysis of randomised controlled trials (2000-2017) assessing eligible treatments for OAB...
April 23, 2018: European Urology
https://www.readbyqxmd.com/read/29675556/patients-perspectives-on-urethral-bulk-injection-therapy-and-mid-urethral-sling-surgery-for-stress-urinary-incontinence
#13
Fenne M Casteleijn, Sandra E Zwolsman, Claudia R Kowalik, Jan-Paul P W R Roovers
INTRODUCTION AND HYPOTHESIS: The aim of this study was to identify all treatment decision factors that determined the preference for peri-urethral bulk injection therapy (PBI) or mid-urethral sling (MUS) surgery in patients with primary stress urinary incontinence (SUI). Second, we explored what patients expect from treatment for SUI and whether patients would consider PBI as a primary treatment option. METHODS: In a qualitative design, 20 semi-structured, face-to-face interviews were conducted in women with primary SUI...
April 19, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29672906/do-brain-structural-abnormalities-differentiate-separate-forms-of-urgency-urinary-incontinence
#14
Becky D Clarkson, Derek Griffiths, Neil M Resnick
AIMS: Urgency urinary incontinence (UUI) is a major problem for seniors. The underlying mechanisms of disease and therapy are unknown. We sought structural brain abnormalities that might underlie the functional differences previously observed by functional Magnetic Resonance Imaging in UUI patients versus controls, or among UUI responders versus non-responders to therapy-and thereby reveal potential disease mechanisms and therapeutic targets. METHODS: Secondary study of a trial of biofeedback-assisted pelvic floor muscle training (BFB) in 60 women (>60 yrs) with UUI, plus 11 age-matched continent controls...
April 19, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29672306/effects-of-bladder-training-and-pelvic-floor-muscle-training-in-female-patients-with-overactive-bladder-syndrome-a-randomized-controlled-trial
#15
Raheela Mohsin Rizvi, Novera Ghayoor Chughtai, Naheed Kapadia
OBJECTIVE: The purpose of our study was to see the efficacy of 3 different modes of treatment for overactive bladder (OAB) in symptoms reduction and quality of life improvement. METHODS: We conducted a 12-week single-blinded randomized controlled trial of women aged 22-65 years with clinical diagnosis of OAB. Arm A (n = 47) received bladder training, arm B (n = 50) received pelvic floor muscle training (PFMT), and arm C (n = 50) received PFMT with biofeedback. Bladder diary was used to assess the difference in urinary frequency, urgency, and leak accidents before and after treatment...
April 19, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29651806/therapeutic-effect-of-propiverine-hydrochloride-on-mixed-type-urinary-incontinence-in-women-the-female-urgency-and-stress-urinary-incontinence-study-of-propiverine-hydrochloride-trial
#16
Tomonori Minagawa, Momokazu Gotoh, Osamu Yokoyama, Kimio Sugaya, Tomonori Yamanishi, Kazuya Kawahara, Kanya Kaga, Takashi Kikuchi, Osamu Nishizawa
OBJECTIVES: To show the efficacy of propiverine hydrochloride in the management of symptoms of stress urinary incontinence in female patients with mixed-type urinary incontinence. METHODS: The study was carried out as a multicenter single-arm clinical trial at 64 institutions in Japan. The participants were female patients aged ≥20 years with mixed-type urinary incontinence. The frequency of stress urinary incontinence and urgency urinary incontinence was evaluated at baseline and 4, 8 and 12 weeks after treatment with propiverine hydrochloride...
April 12, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29651696/diversity-of-the-midstream-urine-microbiome-in-adults-with-chronic-kidney-disease
#17
Holly Kramer, Gina Kuffel, Krystal Thomas-White, Alan J Wolfe, Kavitha Vellanki, David J Leehey, Vinod K Bansal, Linda Brubaker, Robert Flanigan, Julia Koval, Anuradha Wadhwa, Michael J Zilliox
PURPOSE: To examine the characteristics of the midstream urine microbiome in adults with stage 3-5 non-dialysis-dependent chronic kidney disease (CKD). METHODS: Patients with non-dialysis-dependent CKD (estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73 m2 ) and diuretic use were recruited from outpatient nephrology clinics. Midstream voided urine specimens were collected using the clean-catch method. The bacterial composition was determined by sequencing the hypervariable (V4) region of the bacterial 16S ribosomal RNA gene...
April 12, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29644381/autologous-rectus-fascia-sling-placement-in-the-management-of-female-stress-urinary-incontinence
#18
Adam R Miller, Brian J Linder, Deborah J Lightner
INTRODUCTION AND HYPOTHESIS: Autologous pubovaginal sling placement remains a treatment option in index patients, given high, long-term success rates. This video reviews the technical considerations for performing an autologous rectus fascia sling. METHODS: The patient is a 47-year-old woman with stress urinary incontinence (SUI) refractory to conservative management. First, a 10-cm rectus fascial segment is harvested and prepped with placement of nonabsorbable stay sutures for later sling passage...
April 11, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29623450/the-role-of-non-invasive-testing-in-evaluation-and-diagnosis-of-pediatric-lower-urinary-tract-dysfunction
#19
REVIEW
Jason P Van Batavia, Andrew J Combs
PURPOSE OF REVIEW: The symptoms of lower urinary tract dysfunction (LUTD) including urinary incontinence, frequency, and urgency are among the most common reasons children are referred to pediatric urologists. Despite this, the workup for LUTD is often time consuming and a source of frustration for patients, parents, and clinicians alike. In the current review, we summarize the important role non-invasive testing plays in the diagnosis and management of children with LUTD and to show how use of these tests can help avoid the need for more invasive testing in the majority of children...
April 6, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29609421/clinical-efficacy-of-solifenacin-in-the-management-of-diabetes-mellitus-associated-versus-idiopathic-overactive-bladder-symptoms-a-multicenter-prospective-study
#20
Hoon Choi, Jae Hyun Bae, Cheol Young Oh, Seong Jin Jeong, Woo Jin Ko, Jong Bo Choi, Ju Tae Seo, Dong Hwan Lee, Joon Chul Kim, Kwang Woo Lee, Young Ho Kim
PURPOSE: To compare the clinical efficacy of anticholinergics for managing diabetes mellitus-associated overactive bladder (DM OAB) versus idiopathic overactive bladder (OAB) in Korean women. METHODS: We conducted a multicenter, prospective, parallel-group, open-label, 12-week study. Women (20-65 years old) with OAB symptoms for over 3 months were assigned to the DM OAB and idiopathic OAB groups. Changes in the Overactive Bladder Symptom Score (OABSS), urgency, urinary urgency incontinence, nocturia, daytime frequency according to a voiding diary, uroflowmetry, and postvoid residual urine volume (PVR) at the first visit (V1), week 4 (V2), and week 12 (V3) were compared...
March 2018: International Neurourology Journal
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